Dr. Yan Li, PhD - Experimental Therapeutics Centre - Research Fellow

Dr. Yan Li

PhD

Experimental Therapeutics Centre

Research Fellow

Singapore | Singapore

ORCID logohttps://orcid.org/0000-0003-1963-839X

Dr. Yan Li, PhD - Experimental Therapeutics Centre - Research Fellow

Dr. Yan Li

PhD

Introduction

Primary Affiliation: Experimental Therapeutics Centre - Singapore , Singapore

Education

Jan 2008 - Oct 2012
Nanyang Technological University
Ph.D.
School of Biological Sciences
Sep 2003 - Jul 2007
University of Science and Technology of China
B.S.
School of Life Sciences

Experience

Nov 2014 - May 2018
Agency for Science Technology and Research
Research Fellow
Experimental Therapeutics Centre
May 2012 - Nov 2014
Nanyang Technological University
Research Fellow
School of Biological Sciences
Oct 2014 - Oct 2014
RIKEN
Visiting Scientist
NMR Facility, Center for Life Science Technologies
Jul 2014 - Aug 2014
European Centre for High Field Nuclear Magnetic Resonance
Visiting Scientist
May 2018
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Publications

67Publications

775Reads

2465Profile Views

105PubMed Central Citations

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor.

Biomol NMR Assign 2017 Oct 14;11(2):225-229. Epub 2017 Aug 14.

Experimental Therapeutics Centre, Agency for Science, Technology and Research, 31 Biopolis Way Nanos, #03-01, Singapore, 138669, Singapore.

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http://dx.doi.org/10.1007/s12104-017-9753-8DOI Listing
October 2017
36 Reads
1 Citation

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Structure 2017 08 6;25(8):1242-1250.e3. Epub 2017 Jul 6.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.06.006DOI Listing
August 2017
56 Reads
4 Citations
5.620 Impact Factor

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

FEBS Lett 2017 08 20;591(15):2338-2347. Epub 2017 Jul 20.

Experimental Therapeutics Centre Agency for Science Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1002/1873-3468.12741DOI Listing
August 2017
46 Reads
1 Citation
3.170 Impact Factor

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage.

Nat Commun 2016 11 15;7:13410. Epub 2016 Nov 15.

Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore.

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http://dx.doi.org/10.1038/ncomms13410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116066PMC
November 2016
35 Reads
12 Citations
10.742 Impact Factor

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.

Angew Chem Int Ed Engl 2016 09 24;55(39):12068-72. Epub 2016 Aug 24.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore, 138669, Singapore.

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http://dx.doi.org/10.1002/anie.201606609DOI Listing
September 2016
25 Reads
1 Citation
11.261 Impact Factor

Function and conformation analyses of an aspartate substitution of the invariant glycine in the integrin βI domain α1-α1’helix

10.1016/j.bbrep.2016.06.013

Biochemistry and Biophysics Reports

We showed that the αLβ2 integrin with the non-functional mutation G150D cannot be induced with Mg/EGTA to express the mAb KIM127 epitope, which reports the leg-extended conformation. We extended the study to the αIIbβ3, an integrin without an αI domain. The equivalent mutation, i.e. G161D, also resulted in an expressible, but non-adhesive αIIbβ3 integrin. An NMR study of synthetic peptides spanning the α1-α1′ helix of the β3 I domain shows that both wild-type and mutant peptides are α-helical. However, whereas in the wild-type peptide this helix is continuous, the mutant presents a discontinuity, or kink, precisely at the site of mutation G161D. Our results suggest that the mutation may lock integrin heterodimers in a bent conformation that prevents integrin activation via conformational extension.

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September 2016
30 Reads

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

J Biol Chem 2016 08 30;291(34):17743-53. Epub 2016 Jun 30.

From the Experimental Therapeutics Centre, Agency for Science, Technology, and Research (A*STAR), 31 Biopolis Way, Nanos, 03-01, Singapore 138669

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http://dx.doi.org/10.1074/jbc.M116.737429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016168PMC
August 2016
47 Reads
1 Citation
4.573 Impact Factor

Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit.

Biomol NMR Assign 2016 Apr 19;10(1):135-8. Epub 2015 Oct 19.

Experimental Therapeutics Centre, Agency for Science, Technology and Research, 31 Biopolis Way Nanos, #03-01, Singapore, 138669, Singapore.

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http://dx.doi.org/10.1007/s12104-015-9652-9DOI Listing
April 2016
21 Reads
1 Citation

Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome.

Sci Rep 2016 Mar 30;6:23712. Epub 2016 Mar 30.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

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http://dx.doi.org/10.1038/srep23712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812329PMC
March 2016
31 Reads
1 Citation
5.080 Impact Factor

Structure of the transmembrane domain of human nicastrin-a component of γ-secretase.

Sci Rep 2016 Jan 18;6:19522. Epub 2016 Jan 18.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, 138669 Singapore.

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http://www.nature.com/articles/srep19522
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http://dx.doi.org/10.1038/srep19522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726005PMC
January 2016
16 Reads
2 Citations
5.080 Impact Factor

Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition.

Sci Rep 2016 Jan 4;6:18644. Epub 2016 Jan 4.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore.

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http://dx.doi.org/10.1038/srep18644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698671PMC
January 2016
16 Reads
5.080 Impact Factor

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

Biochim Biophys Acta 2015 Dec 25;1848(12):3150-7. Epub 2015 Sep 25.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00052736150030
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http://dx.doi.org/10.1016/j.bbamem.2015.09.016DOI Listing
December 2015
37 Reads
4 Citations

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

Biochem Biophys Res Commun 2015 Nov 17;467(4):961-6. Epub 2015 Oct 17.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.036DOI Listing
November 2015
45 Reads
2 Citations
2.300 Impact Factor

Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.

Biochim Biophys Acta 2015 Oct 11;1848(10 Pt A):2244-52. Epub 2015 Jun 11.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.06.010DOI Listing
October 2015
18 Reads
7 Citations

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

FEBS Lett 2015 Sep 10;589(19 Pt B):2683-9. Epub 2015 Aug 10.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.07.044DOI Listing
September 2015
25 Reads
3 Citations
3.170 Impact Factor

Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles.

Sci Rep 2015 Aug 28;5:13586. Epub 2015 Aug 28.

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, 138669 Singapore.

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http://dx.doi.org/10.1038/srep13586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551963PMC
August 2015
23 Reads
6 Citations
5.080 Impact Factor

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.

Virology 2015 Aug 2;482:105-10. Epub 2015 Apr 2.

School of Biological Sciences, Nanyang Technological University, 637551, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.03.034DOI Listing
August 2015
15 Reads
3 Citations
3.321 Impact Factor

Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?

Viruses 2015 Jun 4;7(6):2858-83. Epub 2015 Jun 4.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

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http://dx.doi.org/10.3390/v7062750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488717PMC
June 2015
68 Reads
3 Citations
3.280 Impact Factor

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.

Virus Res 2015 Apr 27;201:61-6. Epub 2015 Feb 27.

School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2015.02.023DOI Listing
April 2015
19 Reads
9 Citations
2.324 Impact Factor

Characterization of single amino acid substitutions in the β2 integrin subunit of patients with leukocyte adhesion deficiency (LAD)-1.

Blood Cells Mol Dis 2015 Feb 28;54(2):177-82. Epub 2014 Nov 28.

School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10799796140013
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http://dx.doi.org/10.1016/j.bcmd.2014.11.005DOI Listing
February 2015
12 Reads
1 Citation
2.650 Impact Factor

Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment.

J Virol 2014 Oct 6;88(20):11899-914. Epub 2014 Aug 6.

School of Biological Sciences, Nanyang Technological University, Singapore

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http://dx.doi.org/10.1128/JVI.00839-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178740PMC
October 2014
41 Reads
11 Citations
4.440 Impact Factor

Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins.

J Biol Chem 2014 May 25;289(18):12535-49. Epub 2014 Mar 25.

From the School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore.

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http://dx.doi.org/10.1074/jbc.M114.560094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007446PMC
May 2014
15 Reads
7 Citations
4.573 Impact Factor

Transmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.

PLoS One 2013 12;8(9):e74281. Epub 2013 Sep 12.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074281PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771934PMC
May 2014
13 Reads
5 Citations
3.234 Impact Factor

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.

Nucleic Acids Res 2012 Jul 1;40(12):5751-65. Epub 2012 Mar 1.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

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http://dx.doi.org/10.1093/nar/gks192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384315PMC
July 2012
19 Reads
8 Citations
9.112 Impact Factor

Identification of a polyoxometalate inhibitor of the DNA binding activity of Sox2.

ACS Chem Biol 2011 Jun 7;6(6):573-81. Epub 2011 Mar 7.

Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore 138672.

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http://dx.doi.org/10.1021/cb100432xDOI Listing
June 2011
28 Reads
8 Citations
5.331 Impact Factor

Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1.

Acta Crystallogr D Biol Crystallogr 2007 Jun 15;63(Pt 6):730-7. Epub 2007 May 15.

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.

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http://dx.doi.org/10.1107/S0907444907017027DOI Listing
June 2007
25 Reads
1 Citation
7.232 Impact Factor

Purification, partial characterization, crystallization and preliminary X-ray diffraction of a novel cardiotoxin-like basic protein from Naja naja atra (South Anhui) venom.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Feb 27;63(Pt 2):130-4. Epub 2007 Jan 27.

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230027, People's Republic of China.

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http://dx.doi.org/10.1107/S1744309107002564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330133PMC
February 2007
22 Reads
1 Citation
0.570 Impact Factor

Top co-authors

Congbao Kang
Congbao Kang

Vanderbilt University School of Medicine

15
Michelle Yueqi Lee
Michelle Yueqi Lee

Experimental Therapeutics Centre

8
Hui Qi Ng
Hui Qi Ng

Institute of Chemical & Engineering Sciences

7
Jaume Torres
Jaume Torres

School of Biological Sciences

7
Thomas H Keller
Thomas H Keller

Experimental Therapeutics Centre

7
Alvin W Hung
Alvin W Hung

University of Cambridge

6
Wahyu Surya
Wahyu Surya

Nanyang Technological University

5
Jeffrey Hill
Jeffrey Hill

University of Massachusetts Medical School

5
Joseph Cherian
Joseph Cherian

McMaster University

4