Publications by authors named "Yalan Zhang"

56 Publications

A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.

J Neurooncol 2021 Jun 14. Epub 2021 Jun 14.

Division of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, CA, USA.

Introduction: Anaplastic oligodendrogliomas are high-grade gliomas defined molecularly by 1p19q co-deletion. There is no curative therapy, and standard of care includes surgical resection followed by radiation and chemotherapy. However, the benefit of up-front radiation with chemotherapy compared to chemotherapy alone has not been demonstrated in a randomized control trial. Given the potential long-term consequences of radiation therapy, such as cognitive impairment, arteriopathy, endocrinopathy, and hearing/visual impairment, there is an effort to balance longevity with radiation toxicity.

Methods: We performed a retrospective single institution analysis of survival of patients with anaplastic oligodendroglioma over 20 years.

Results: 159 patients were identified as diagnosed with an anaplastic oligodendroglioma between 1996 and 2016. Of those, 40 patients were found to have AO at original diagnosis and had documented 1p19q co-deletion with a median of 7.1 years of follow-up (range: 0.6-16.7 years). After surgery, 45 % of patients were treated with radiation and chemotherapy at diagnosis, and 50 % were treated with adjuvant chemotherapy alone. The group treated with chemotherapy alone had a trend of receiving more cycles of chemotherapy than patients treated with radiation and chemotherapy upfront (p = 0.051). Median overall survival has not yet been reached. The related risk of progression in the upfront, adjuvant chemotherapy only group was almost 5-fold higher than the patients who received radiation and chemotherapy (hazard ratio = 4.85 (1.74-13.49), p = 0.002). However, there was no significant difference in overall survival in patients treated with upfront chemotherapy compared to patients treated upfront with chemotherapy and radiation (p = 0.8). Univariate analysis of age, KPS, extent of resection, or upfront versus delayed radiation was not associated with improved survival.

Conclusions: Initial treatment with adjuvant chemotherapy alone, rather than radiation and chemotherapy, may be an option for some patients with anaplastic oligodendroglioma, as it is associated with similar overall survival despite shorter progression free survival.
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http://dx.doi.org/10.1007/s11060-021-03781-zDOI Listing
June 2021

Effective Phase-Alignment for 2D Halide Perovskites Incorporating Symmetric Diammonium Ion for Photovoltaics.

Adv Sci (Weinh) 2021 May 24:e2001433. Epub 2021 May 24.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an, 710119, China.

New structural type of 2D AA' M X type halide perovskites stabilized by symmetric diammonium cations has attracted research attention recently due to the short interlayer distance and better charge-transport for high-performance solar cells (PSCs). However, the distribution control of quantum wells (QWs) and its influence on optoelectronic properties are largely underexplored. Here effective phase-alignment is reported through dynamical control of film formation to improve charge transfer between quantum wells (QWs) for 2D perovskite (BDA)(MA) Pb I (BDA = 1,4-butanediamine, 〈n〉 = 4) film. The in situ optical spectra reveal a significantly prolonged crystallization window during the perovskite deposition via additive strategy. It is found that finer thickness gradient by n values in the direction orthogonal to the substrate leads to more efficient charge transport between QWs and suppressed charge recombination in the additive-treated film. As a result, a power conversion efficiency of 14.4% is achieved, which is not only 21% higher than the control one without additive treatment, but also one of the high efficiencies of the low-n (n ≤ 4) AA' M X PSCs. Furthermore, the bare device retains 92% of its initial PCE without any encapsulation after ambient exposure for 1200 h.
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http://dx.doi.org/10.1002/advs.202001433DOI Listing
May 2021

Prevalence and Risk Factors for Anxiety and Depression in Patients With COVID-19 in Wuhan, China.

Psychosom Med 2021 05;83(4):368-372

From the Surgery Intensive Care Unit (Li, Liu, Wang, Zhang, Gong, Duan) China-Japan Friendship Hospital; and Peking University Institute of Mental Health (Sun), National Clinical Research Center for Mental Disorders, Beijing, China.

Objective: Infectious diseases can cause psychological changes in patients. This study aimed to evaluate the prevalence and related risk factors for anxiety and depression in patients with COVID-19.

Methods: A cross-sectional study was performed on patients with COVID-19 admitted to the Sino-French New City branch of Wuhan Tongji Hospital from January to February 2020. The Zung Self-Rating Anxiety and Depression Scales were used to evaluate the prevalence of anxiety and depression. Demographic, clinical, and sociological data were also collected. Multivariable logistic regression analysis was used to identify independent risk factors of anxiety and depression in patients with COVID-19.

Results: In the current study, 183 patients were enrolled (mean age = 53 ± 9 years; 41.1% women). The prevalences of anxiety and depression were 56.3% and 39.3%, respectively. Logistic regression analysis revealed that older age, female sex, being divorced or widowed, COVID-19 disease duration, renal disease, and depression were identified as independent risk factors for anxiety in patients with COVID-19. Factors that were associated with depression were female sex, being widowed, COVID-19 disease duration, and anxiety.

Conclusions: This study demonstrates a high prevalence of anxiety and depression in patients with COVID-19 at the peak of the epidemic in Wuhan, China. The identification of demographic, clinical, and social factors may help identify health care professionals to provide psychological care as part of treatment for patients with COVID-19 and other life-threatening infectious diseases.
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http://dx.doi.org/10.1097/PSY.0000000000000934DOI Listing
May 2021

Sustainability efficiency assessment of listed companies in China: a super-efficiency SBM-DEA model considering undesirable output.

Environ Sci Pollut Res Int 2021 Apr 24. Epub 2021 Apr 24.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Chinese listed companies play a vital role in national economy, which has contributed more than half of the gross domestic product. But the environmental pollution existed in the production and operation of companies has been ignored, so an objective and comprehensive efficiency assessment of Chinese listed companies were urgent. This paper constructed an index system based on green perspective, employed a super-efficiency slacks-based measure DEA (SBM-DEA) model considering undesirable outputs to assess the sustainability efficiency of Chinese listed companies. The results indicated that (1) the green sustainability efficiency of listed companies needed to be greatly improved. The average efficiency score of samples was 0.461 over 3 years, so the improvement potential was about 53.9%, only 23 companies were relatively effective. (2) The sustainability efficiency of companies has shown a slow upward trend in volatility since 2017, the non-daily consumer goods sector was the most efficient, while utilities were relatively inefficient. (3) When efficient and inefficient companies were compared, the latter were found to have significant input surplus, especially in water consumption. (4) The analysis of sensitivity on inputs and outputs showed that attention should be paid to water consumption and greenhouse gas emissions. (5) Spearman non-parametric test verified that company size and debt-paying ability were the implicit factors affecting company sustainability efficiency. The results of performance evaluation can not only provide a potential reference for the operation and management of listed companies in China, but also have guiding significance for local governments to strengthen the supervision of companies.
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http://dx.doi.org/10.1007/s11356-021-13997-1DOI Listing
April 2021

Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.

Nat Commun 2021 03 19;12(1):1731. Epub 2021 Mar 19.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.

Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here, we report that Kv3.3 channels bind and stimulate Tank Binding Kinase 1 (TBK1), an enzyme that controls trafficking of membrane proteins into multivesicular bodies, and that this stimulation is greatly increased by a disease-causing Kv3.3 mutation. TBK1 activity is required for the binding of Kv3.3 to its auxiliary subunit Hax-1, which prevents channel inactivation with depolarization. Hax-1 is also an anti-apoptotic protein required for survival of cerebellar neurons. Overactivation of TBK1 by the mutant channel leads to the loss of Hax-1 by its accumulation in multivesicular bodies and lysosomes, and also stimulates exosome release from neurons. This process is coupled to activation of caspases and increased cell death. Our studies indicate that Kv3.3 channels are directly coupled to TBK1-dependent biochemical pathways that determine the trafficking of cellular constituents and neuronal survival.
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http://dx.doi.org/10.1038/s41467-021-22003-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979925PMC
March 2021

Dual Passivation of Perovskite and SnO for High-Efficiency MAPbI Perovskite Solar Cells.

Adv Sci (Weinh) 2021 Mar 29;8(5):2001466. Epub 2021 Jan 29.

Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China.

So far, most techniques for modifying perovskite solar cells (PSCs) focus on either the perovskite or electron transport layer (ETL). For the sake of comprehensively improving device performance, a dual-functional method of simultaneously passivating trap defects in both the perovskite and ETL films is proposed that utilizes guidable transfer of Eu in SnO to perovskite. Europium ions are distributed throughout the SnO film during the formation process of SnO, and they can diffuse directionally through the SnO/perovskite interface into the perovskite, while most of the europium ions remain at the interface. Under the synergistic effect of distributed Eu in the SnO and aggregated Eu at the interface, the electron mobilities of ETLs are evidently improved. Meanwhile, diffused Eu ions passivate the perovskite to reduce trap densities at the grain boundaries, which can dramatically elevate the open-circuit voltage () of PSCs. Finally, the mainly PSCs coated on SnO:Eu ETL achieve a power conversion efficiency of 20.14%. Moreover, an unsealed device degrades by only 13% after exposure to ambient atmosphere for 84 days.
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http://dx.doi.org/10.1002/advs.202001466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927604PMC
March 2021

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.

Neuron 2021 03 27;109(6):938-946.e5. Epub 2021 Jan 27.

National Institute of Neurological Disorders and Stroke, 35 Convent Dr., Bethesda, MD 20892, USA. Electronic address:

Since their discovery decades ago, the primary physiological and pathological effects of potassium channels have been attributed to their ion conductance, which sets membrane potential and repolarizes action potentials. For example, Kv3 family channels regulate neurotransmitter release by repolarizing action potentials. Here we report a surprising but crucial function independent of potassium conductance: by organizing the F-actin cytoskeleton in mouse nerve terminals, the Kv3.3 protein facilitates slow endocytosis, rapid endocytosis, vesicle mobilization to the readily releasable pool, and recovery of synaptic depression during repetitive firing. A channel mutation that causes spinocerebellar ataxia inhibits endocytosis, vesicle mobilization, and synaptic transmission during repetitive firing by disrupting the ability of the channel to nucleate F-actin. These results unmask novel functions of potassium channels in endocytosis and vesicle mobilization crucial for sustaining synaptic transmission during repetitive firing. Potassium channel mutations that impair these "non-conducting" functions may thus contribute to generation of diverse neurological disorders.
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http://dx.doi.org/10.1016/j.neuron.2021.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979485PMC
March 2021

Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa142. Epub 2020 Oct 22.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Background: "Diffuse midline glioma (DMG), H3 K27M-mutant" is a new tumor entity established in the 2016 WHO classification of Tumors of the Central Nervous System that comprises a set of diffuse gliomas arising in midline structures and is molecularly defined by a K27M mutation in genes encoding the histone 3 variants H3.3 or H3.1. While this tumor entity is associated with poor prognosis in children, clinical experience in adults remains limited.

Methods: Patient demographics, radiologic and pathologic characteristics, treatment course, progression, and patient survival were collected for 60 adult patients with DMG, H3 K27M-mutant. A subset of tumors also underwent next-generation sequencing. Analysis of progression-free survival and overall survival was conducted using Kaplan-Meier modeling, and univariate and multivariate analysis.

Results: Median patient age was 32 years (range 18-71 years). Tumors were centered in the thalamus ( = 34), spinal cord (10), brainstem (5), cerebellum (4), or other midline sites (4), or were multifocal (3). Genomic profiling revealed p.K27M mutations exclusively in the gene and an absence of mutations in , which are present in approximately one-third of pediatric DMGs. Accompanying mutations in , , , , and were frequently found. The overall survival of this adult cohort was 27.6 months, longer than historical averages for both H3 K27M-mutant DMG in children and IDH-wildtype glioblastoma in adults.

Conclusions: Together, these findings indicate that H3 K27M-mutant DMG represents a heterogeneous disease with regard to outcomes, sites of origin, and molecular pathogenesis in adults versus children.
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http://dx.doi.org/10.1093/noajnl/vdaa142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739048PMC
October 2020

Cell membrane-encapsulated magnetic nanoparticles for enhancing natural killer cell-mediated cancer immunotherapy.

Nanomedicine 2021 02 12;32:102333. Epub 2020 Nov 12.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Electronic address:

Natural killer (NK) cells have exhibited therapeutic potential for various malignant tumors. However, the cytotoxic effect of NK cells is relatively weak and less specific compared to other immunotherapy approaches such as chimeric antigen receptor T-Cell (CART) therapy, constituting a great challenge for adoptive immunotherapy. Here, we report cell membrane-encapsulated magnetic nanoparticles for activating NK cells and enhancing anti-tumor effects. Magnetic nanoparticles were coated with silicon dioxide (SiO), and cancer cell membranes were mixed with [email protected] to construct cancer cell membrane coated [email protected] magnetic nanoparticles (CMNPs). The functionalized nanoparticles bearing cancer-specific antigens on the surface effectively stimulated NK cells by enhancing expression of surface activating receptors and boosting anti-tumor function through the secretion of soluble cytotoxic effectors. To conclude, the biomimetic magnetic nanoparticles offer a versatile and powerful tool to present tumor-specific antigens, priming anti-tumor capability, which is promising to enhance NK cell-based adoptive cancer immunotherapy.
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http://dx.doi.org/10.1016/j.nano.2020.102333DOI Listing
February 2021

Effects of incorporation with clove (Eugenia caryophyllata) essential oil (CEO) on overall performance of chitosan as active coating.

Int J Biol Macromol 2021 Jan 31;166:578-586. Epub 2020 Oct 31.

School of Public Health, Southern Medical University, Guangzhou, Guangdong Province 510515, China. Electronic address:

This research is focused on improving performance of chitosan based functional material by introducing active additive. A series of assays revealed incorporation with clove essential oil (CEO) significantly improved the physical, chemical and antimicrobial performance of chitosan. In this work, the prepared chitosan-CEO film (CH-CEO) showed varieties in color parameters, mechanical strength and water vapor permeability. Moreover, chitosan was endowed with significant antioxidant and antimicrobial activities, thereby it was used as protective coatings for fresh-cutting apple tubes at ~1 °C. Results demonstrated the treatment slowed down the quality deterioration process of preserved apple samples, especially for firmness and color. As well, CH-CEO coating reduced microbial counts in the preserved apple samples and inhibited the varieties in the chemical properties. The overall observations revealed that CH-CEO film has remarkable potential as an antioxidant and antimicrobial material, especially as an active coating for fresh-cutting foods during storage.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.10.215DOI Listing
January 2021

Effects of walkability on physical activity and obesity: a prospective observational study protocol.

BMJ Open 2020 10 10;10(10):e034882. Epub 2020 Oct 10.

Health Management Centre, First Affiliated Hospital to Army Medical University, Chongqing, China

Introduction: The prevalence of overweight and obesity is increasing worldwide, which could lead to a set of chronic and metabolic diseases. Physical activity is a modifiable factor for obesity, which was reported to be correlated with the built environment. However, the effects of the built environment on physical activity are not consistent. Walkability is a convenient way to assess the built environment. We aim to prospectively explore the relationship among walkability, physical activity and obesity in Chinese participants in Chongqing, a hilly city and provide evidence for future urban planning.

Methods And Analysis: Participants will be recruited from people who receive health examination in the Health Management Centre, the First Affiliated Hospital to Army Medical University. Exposure variables are WalkScores calculated within the areas around workplace and residential addresses of participants. The primary outcomes are body mass index measured through health examination at baseline and follow-ups, and daily walking steps recorded by WeChat mini application for 30 days after every time of health examination. Other health-related data of the participants will also be collected. Multivariate regression analysis will be performed to examine the relationship between exposure variables and outcomes.

Ethics And Dissemination: The Protocol is approved by the Ethics Committee of the First Affiliated Hospital to Army Medical University (KY201839). The results will be actively disseminated through peer-review journals and conference publications.

Registration Number: Chinese Clinical Trial Registry (ChiCTR1800017680).
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http://dx.doi.org/10.1136/bmjopen-2019-034882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554499PMC
October 2020

Antimonene Quantum Dots as an Emerging Fluorescent Nanoprobe for the pH-Mediated Dual-Channel Detection of Tetracyclines.

Small 2020 10 29;16(42):e2003429. Epub 2020 Sep 29.

College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Antimonene quantum dots (AMQDs) are attracting considerable attention due to their fascinating physicochemical properties. However, research on their semiconductor characteristics, especially the photoluminescence performance, is still in a preliminary stage and the experimental verification is scarcely reported, significantly restricting their further applications. Herein, the photoluminescence property of AMQDs is experimentally verified. The AMQDs are prepared by probe sonication-assisted liquid-phase exfoliation and show robust blue fluorescence, and the photoluminescence is hardly affected by pH. In view of the derivatization reaction of tetracyclines (TET) at different pHs, AMQDs are developed as a pH-mediated dual-channel ratiometric fluorescent probe for TET detection. Under acidic conditions, the AMQDs' probe exhibits unique recognition behavior due to the inherent fluorescence of TET and the solvent-enhancing effect, that is, the fluorescence changes from blue to red. Under alkaline conditions, this fluorescent probe realizes the transition from blue to yellow-green because of the decomposition of TET. The limits of detection are 27 × 10 and 74 × 10 m, respectively. The high sensitivity and remarkable fluorescence changes make AMQDs ideal probes for TET sensing. Additionally, this is the first report on the photoluminescence property of AMQDs. It is believed that this work will open a new avenue for AMQDs in optical sensing fields.
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http://dx.doi.org/10.1002/smll.202003429DOI Listing
October 2020

Printable CsPbI Perovskite Solar Cells with PCE of 19% via an Additive Strategy.

Adv Mater 2020 Oct 31;32(40):e2001243. Epub 2020 Aug 31.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an, 710119, China.

All-inorganic CsPbI holds promise for efficient tandem solar cells, but reported fabrication techniques are not transferrable to scalable manufacturing methods. Herein, printable CsPbI solar cells are reported, in which the charge transporting layers and photoactive layer are deposited by fast blade-coating at a low temperature (≤100 °C) in ambient conditions. High-quality CsPbI films are grown via introducing a low concentration of the multifunctional molecular additive Zn(C F ) , which reconciles the conflict between air-flow-assisted fast drying and low-quality film including energy misalignment and trap formation. Material analysis reveals a preferential accumulation of the additive close to the perovskite/SnO interface and strong chemisorption on the perovskite surface, which leads to the formation of energy gradients and suppressed trap formation within the perovskite film, as well as a 150 meV improvement of the energetic alignment at the perovskite/SnO interface. The combined benefits translate into significant enhancement of the power conversion efficiency to 19% for printable solar cells. The devices without encapsulation degrade only by ≈2% after 700 h in air conditions.
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http://dx.doi.org/10.1002/adma.202001243DOI Listing
October 2020

Chitosan-based bifunctional composite aerogel combining absorption and phototherapy for bacteria elimination.

Carbohydr Polym 2020 Nov 8;247:116739. Epub 2020 Jul 8.

College of Food Science and Engineering, Northwest A&F University, Yangling, 712100 Shanxi, China. Electronic address:

The bacterial infection is one of the most common but critical problems in the wound healing process due to the general antibiotic resistance of bacteria. Hence it is increasingly necessary and urgent to develop an advanced and efficient sterilization strategy. Herein, a chitosan-based aerogel embedded amino-functionalized molybdenum disulfide nanosheets (abbreviated to CS/NMNSs) was successfully constructed through amino modification and physical assembly. Scanning electron microscopy characterizations and swelling experiments indicated that freeze-dried chitosan aerogel is provided with extremely regular sponge-like structure, high porosity, and favorable swelling property. The CS aerogel can be used as an ideal bacterial adsorption agent ascribed to its inherent positive charge. The result of antibacterial studies showed that the CS/NMNSs exhibited efficient bacterial elimination capacity via capture ability of chitosan aerogel and near infrared induced photothermal sterilization. Therefore, the CS/NMNSs have great potential in developing as a photothermal antibacterial agent in future application.
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http://dx.doi.org/10.1016/j.carbpol.2020.116739DOI Listing
November 2020

A bifunctional nanoplatform based on copper manganate nanoflakes for bacterial elimination via a catalytic and photothermal synergistic effect.

Biomater Sci 2020 Jul;8(15):4266-4274

College of Food Science and Engineering, Northwest A&F University, Yangling712100, Shaanxi, China.

Bacterial infection has been recognized as one of the greatest threats to public health. In view of the continuous increase of bacterial resistance, constructing a collaborative bactericidal platform is a promising strategy to enhance the efficiency of antimicrobial agents. Herein, we report a facile, biocompatible and versatile nano-platform based on positively charged copper manganate nanoflakes (CuMnO2 NFs), which exhibits intrinsic peroxidase-like catalytic activity and excellent photothermal properties. The CuMnO2 NFs can bind with negatively charged bacteria via electrostatic interactions, and generate hydroxyl radicals (˙OH) through catalysis involving hydrogen peroxide (H2O2) to make bacteria more susceptible to temperature. Introducing near-infrared light generates hyperthermia to fight against bacteria and enhances the peroxidase-like catalytic activity of the CuMnO2 NFs, thus producing more ˙OH to combat bacteria. The PTT-enhanced ˙OH synergistic antibacterial strategy exerts desirable antibacterial efficiencies of 98.78% and 99.92% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at a controlled low temperature (below 50 °C), without damage to healthy tissues. Animal experiments indicate that this synergistic treatment has a better therapeutic effect on S. aureus-infected wounds in mice, compared with either treatment by itself. Therefore, this work holds great promise for developing new synergistic antimicrobial strategies to treat bacterial infections.
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http://dx.doi.org/10.1039/d0bm00706dDOI Listing
July 2020

Influence of Different Inactivation Methods on Severe Acute Respiratory Syndrome Coronavirus 2 RNA Copy Number.

J Clin Microbiol 2020 Jul 23;58(8). Epub 2020 Jul 23.

Xi'an Center for Disease Control and Prevention, Xi'an, Shaanxi, China

The outbreak of coronavirus disease 2019 (COVID-19) has spread across the world and was characterized as a pandemic. To protect medical laboratory personnel from infection, most laboratories inactivate the virus causing COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in clinical samples before testing. However, the effect of inactivation on the detection results remains unknown. Here, we used a digital PCR assay to determine the absolute SARS-CoV-2 RNA copy number in 63 nasopharyngeal swab samples and assess the effect of inactivation methods on viral RNA copy number. Viral inactivation was performed by three different methods: (i) incubation with the TRIzol LS reagent for 10 min at room temperature, (ii) heating in a water bath at 56°C for 30 min, and (iii) high-temperature treatment, including autoclaving at 121°C for 20 min, boiling at 100°C for 20 min, and heating at 80°C for 20 min. Compared to the amount of RNA in the original sample, TRIzol treatment destroyed 47.54% of the nucleocapsid protein (N) gene and 39.85% of open reading frame (ORF) 1ab. For samples treated at 56°C for 30 min, the copy number of the N gene and ORF 1ab was reduced by 48.55% and 56.40%, respectively. The viral RNA copy number dropped by 50 to 66% after heating at 80°C for 20 min. Nearly no viral RNA was detected after autoclaving at 121°C or boiling at 100°C for 20 min. These results indicate that inactivation reduced the quantity of detectable viral RNA and may cause false-negative results, especially in weakly positive cases. Thus, use of the TRIzol reagent rather than heat inactivation is recommended for sample inactivation, as the TRIzol reagent had the least effect on the RNA copy number among the tested methods.
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http://dx.doi.org/10.1128/JCM.00958-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383554PMC
July 2020

The impact of obesity on perioperative complications in patients undergoing anterior lumbar interbody fusion.

J Neurosurg Spine 2020 Apr 24:1-10. Epub 2020 Apr 24.

1Department of Neurological Surgery, University of California, San Francisco.

Objective: Anterior approaches to the lumbar spine provide wide exposure that facilitates placement of large grafts with high fusion rates. There are limited data on the effects of obesity on perioperative complications.

Methods: Data from consecutive patients undergoing anterior lumbar interbody fusion (ALIF) from 2007 to 2016 at a single academic center were analyzed. The primary outcome was any perioperative complication. Complications were divided into those occurring intraoperatively and those occurring postoperatively. Multivariate logistic regression was used to assess the association of obesity and other variables with these complications. An estimation table was used to identify a body mass index (BMI) threshold associated with increased risk of postoperative complication.

Results: A total of 938 patients were identified, and the mean age was 57 years; 511 were females (54.5%). The mean BMI was 28.7 kg/m2, with 354 (37.7%) patients classified as obese (BMI ≥ 30 kg/m2). Forty patients (4.3%) underwent a lateral transthoracic approach, while the remaining 898 (95.7%) underwent a transabdominal retroperitoneal approach. Among patients undergoing transabdominal retroperitoneal ALIF, complication rates were higher for obese patients than for nonobese patients (37.0% vs 28.7%, p = 0.010), a difference that was driven primarily by postoperative complications (36.1% vs 26.0%, p = 0.001) rather than intraoperative complications (3.2% vs 4.3%, p = 0.416). Obese patients had higher rates of ileus (11.7% vs 7.2%, p = 0.020), wound complications (11.4% vs 3.4%, p < 0.001), and urinary tract infections (UTI) (5.0% vs 2.5%, p = 0.049). In a multivariate model, age, obesity, and number of ALIF levels fused were associated with an increased risk of postoperative complication. An estimation table including 19 candidate cut-points, odds ratios, and adjusted p values found a BMI ≥ 31 kg/m2 to have the highest association with postoperative complication (p = 0.012).

Conclusions: Obesity is associated with increased postoperative complications in ALIF, including ileus, wound complications, and UTI. ALIF is a safe and effective procedure. However, patients with a BMI ≥ 31 kg/m2 should be counseled on their increased risks and warrant careful preoperative medical optimization and close monitoring in the postoperative setting.
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http://dx.doi.org/10.3171/2020.2.SPINE191418DOI Listing
April 2020

Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China.

Eur J Clin Nutr 2020 Jun 22;74(6):871-875. Epub 2020 Apr 22.

China-Japan Friendship Hospital, Beijing, China.

Background/objectives: To evaluate the prevalence of malnutrition and its related factors in elderly patients with COVID-19 in Wuhan, China.

Subjects/methods: In a cross-sectional study, we evaluated the nutritional status of elderly inpatients with COVID-19 using the Mini Nutritional Assessment (MNA). Based on MNA scores, patients were divided into non-malnutrition group (MNA ≥ 24), the group with risk of malnutrition (MNA 17-23.5) and malnutrition group (MNA score < 17). Regression analysis was conducted to screen for risk factors for malnutrition.

Results: A total of 182 patients were included in the study, of which 27.5% were in the group with malnutrition risk and 52.7% were in the malnutrition group. There were statistical differences in the incidence of comorbid diabetes mellitus, body mass index (BMI), calf circumference,albumin, hemoglobin, and lymphocyte counts among the three groups. Further regression analysis suggested that combined diabetes, low calf circumference, and low albumin were independent risk factors for malnutrition.

Conclusions: The prevalence of malnutrition in elderly patients with COVID-19 was high, and nutritional support should be strengthened during treatment, especially for those with diabetes mellitus, low calf circumference, or low albumin.
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http://dx.doi.org/10.1038/s41430-020-0642-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175450PMC
June 2020

Safety and efficacy of direct nerve root decompression via anterior cervical discectomy and fusion with uncinectomy for cervical radiculopathy.

J Spine Surg 2020 Mar;6(1):205-209

Department of Neurological Surgery, University of California, San Francisco, CA, USA.

Cervical radiculopathy is a common spinal condition associated with pain, sensory disturbances, and motor weakness. Symptoms often can be attributable to either disc herniation and/or bony foraminal stenosis due to uncinate hypertrophy. Posterior cervical foraminotomy and conventional anterior cervical discectomy and fusion (ACDF) represent the mainstay of treatment. In patients with severe bony foraminal stenosis, posterior foraminotomy and standard ACDF without complete resection of uncinate process may result in incomplete decompression. ACDF with uncinectomy allows for complete and direct decompression of the exiting nerve root, and may lead to improved clinical outcome in appropriately selected patients. We describe the technique for ACDF with uncinectomy and report the clinical outcome in a consecutive series of patients.
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http://dx.doi.org/10.21037/jss.2019.12.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154367PMC
March 2020

Comparative effectiveness of bariatric surgeries in patients with obesity and type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials.

Obes Rev 2020 08 14;21(8):e13030. Epub 2020 Apr 14.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

A network meta-analysis of randomized controlled trials (RCTs) was performed to determine the hierarchies of different bariatric surgeries in patients with obesity and type 2 diabetes mellitus (T2DM), in terms of diabetes remission and cardiometabolic outcomes. Seventeen RCTs and six bariatric surgeries, including single anastomosis (mini) gastric bypass (mini-GBP), biliopancreatic diversion without duodenal switch (BPD), laparoscopic-adjustable gastric banding (LAGB), laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGBP), greater curvature plication (GCP) and nonsurgical treatments (NST) were included. Mini-GBP, BPD, LSG, RYGBP and LAGB (from best to worst), as compared with NST, were all significantly associated with the remission of T2DM. For the follow-up period > 3 years, BPD, mini-GBP, RYGBP and LSG (from best to worst) were significantly superior to NST in achieving the remission of T2DM. For secondary outcomes, the overall ranking for bariatric surgeries was RYGBP > BPD > LSG > LAGB after comprehensively weighting glucose, weight, systolic and diastolic pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Mini-GBP has the greatest probability of achieving diabetes remission in adults with obesity and T2DM, yet BPD was the most effective in long-term diabetes remission. RYGBP appears to be the most favourable alternative treatment to manage patients with cardiometabolic conditions.
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http://dx.doi.org/10.1111/obr.13030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379237PMC
August 2020

A formula based on autonomic test using EZSCAN and anthropometric data for diagnosis of DM in China.

Sci Rep 2020 03 17;10(1):4870. Epub 2020 Mar 17.

Department of Transfusion Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Clinical diagnosis of diabetes mellitus (DM) is time-consuming and invasive. This study aimed to investigate the efficacy and accuracy of EZSCAN in detecting impaired glucose tolerance (IGT) and diabetes mellitus (DM) in Chinese population, and explore a diagnosis formula based on an autonomic test using EZSCAN measurement and anthropometric data. Eligible subjects (n = 1547) had the following data collected: those of anthropometric and EZSCAN measurements and biochemical tests including FPG, OGTT, HbA1c, and serum lipid tests. The support vector machine (SVM) algorithm method was used to derive a diagnostic formula. In this study, 452 and 263 subjects were diagnosed with T2DM and IGT, respectively, while 832 had normal glucose tolerance (NGT). The sensitivity rates for the formula were 77.2% for T2DM and 80.4% for IGT. The diagnostic formula was found to correlate strongly with EZSCAN values. The diagnostic formula based on autonomic test and anthropometric data appears to be a convenient and accurate routine screening option in the Chinese population.
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http://dx.doi.org/10.1038/s41598-020-61841-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078247PMC
March 2020

MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence.

Neuro Oncol 2020 11;22(11):1580-1590

Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.

Background: Emerging data suggest that a subset of patients with diffuse isocitrate dehydrogenase (IDH)-mutant low-grade glioma (LGG) who receive adjuvant temozolomide (TMZ) recur with hypermutation in association with malignant progression to higher-grade tumors. It is currently unclear why some TMZ-treated LGG patients recur with hypermutation while others do not. MGMT encodes O6-methylguanine-DNA methyltransferase, a DNA repair protein that removes cytotoxic and potentially mutagenic lesions induced by TMZ. Here, we hypothesize that epigenetic silencing of MGMT by promoter methylation facilitates TMZ-induced mutagenesis in LGG patients and contributes to development of hypermutation at recurrence.

Methods: We utilize a quantitative deep sequencing assay to characterize MGMT promoter methylation in 109 surgical tissue specimens from initial tumors and post-treatment recurrences of 37 TMZ-treated LGG patients. We utilize methylation arrays to validate our sequencing assay, RNA sequencing to assess the relationship between methylation and gene expression, and exome sequencing to determine hypermutation status.

Results: Methylation level at the MGMT promoter is significantly higher in initial tumors of patients that develop hypermutation at recurrence relative to initial tumors of patients that do not (45.7% vs 34.8%, P = 0.027). Methylation level in initial tumors can predict hypermutation at recurrence in univariate models and multivariate models that incorporate patient age and molecular subtype.

Conclusions: These findings reveal a mechanistic basis for observed differences in patient susceptibility to TMZ-driven hypermutation. Furthermore, they establish MGMT promoter methylation level as a potential biomarker to inform clinical management of LGG patients, including monitoring and treatment decisions, by predicting risk of hypermutation at recurrence.
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http://dx.doi.org/10.1093/neuonc/noaa059DOI Listing
November 2020

Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.

JAMA Oncol 2020 04;6(4):495-503

Department of Neurological Surgery, University of California, San Francisco.

Importance: Per the World Health Organization 2016 integrative classification, newly diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH)-wild-type and IDH-mutant subtypes, with median patient survival of 1.2 and 3.6 years, respectively. Although maximal resection of contrast-enhanced (CE) tumor is associated with longer survival, the prognostic importance of maximal resection within molecular subgroups and the potential importance of resection of non-contrast-enhanced (NCE) disease is poorly understood.

Objective: To assess the association of resection of CE and NCE tumors in conjunction with molecular and clinical information to develop a new road map for cytoreductive surgery.

Design, Setting, And Participants: This retrospective, multicenter cohort study included a development cohort from the University of California, San Francisco (761 patients diagnosed from January 1, 1997, through December 31, 2017, with 9.6 years of follow-up) and validation cohorts from the Mayo Clinic (107 patients diagnosed from January 1, 2004, through December 31, 2014, with 5.7 years of follow-up) and the Ohio Brain Tumor Study (99 patients with data collected from January 1, 2008, through December 31, 2011, with a median follow-up of 10.9 months). Image accessors were blinded to patient groupings. Eligible patients underwent surgical resection for newly diagnosed glioblastoma and had available survival, molecular, and clinical data and preoperative and postoperative magnetic resonance images. Data were analyzed from November 15, 2018, to March 15, 2019.

Main Outcomes And Measures: Overall survival.

Results: Among the 761 patients included in the development cohort (468 [61.5%] men; median age, 60 [interquartile range, 51.6-67.7] years), younger patients with IDH-wild-type tumors and aggressive resection of CE and NCE tumors had survival similar to that of patients with IDH-mutant tumors (median overall survival [OS], 37.3 [95% CI, 31.6-70.7] months). Younger patients with IDH-wild-type tumors and reduction of CE tumor but residual NCE tumors fared worse (median OS, 16.5 [95% CI, 14.7-18.3] months). Older patients with IDH-wild-type tumors benefited from reduction of CE tumor (median OS, 12.4 [95% CI, 11.4-14.0] months). The results were validated in the 2 external cohorts. The association between aggressive CE and NCE in patients with IDH-wild-type tumors was not attenuated by the methylation status of the promoter region of the DNA repair enzyme O6-methylguanine-DNA methyltransferase.

Conclusions And Relevance: This study confirms an association between maximal resection of CE tumor and OS in patients with glioblastoma across all subgroups. In addition, maximal resection of NCE tumor was associated with longer OS in younger patients, regardless of IDH status, and among patients with IDH-wild-type glioblastoma regardless of the methylation status of the promoter region of the DNA repair enzyme O6-methylguanine-DNA methyltransferase. These conclusions may help reassess surgical strategies for individual patients with newly diagnosed glioblastoma.
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http://dx.doi.org/10.1001/jamaoncol.2019.6143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042822PMC
April 2020

Self-Healable Magnetic Structural Color Hydrogels.

ACS Appl Mater Interfaces 2020 Feb 30;12(6):7486-7493. Epub 2020 Jan 30.

Department of Clinical Laboratory, Nanjing Drum Tower Hospital , Clinical College of Xuzhou Medical University , Nanjing 210008 , China.

Biologically inspired structural color hydrogels with magnetic- and photothermal-controlled self-healable abilities were fabricated by integrating magnetic-responsive photonic crystals into gelatin hydrogels. The self-healable ability of the hydrogel systems was derived from the magnetic response and light-absorbing abilities of the magnetic nanoparticles. When the hydrogels deteriorate or get damaged, magnetic nanoparticles could absorb heat under near-infrared irradiation and external magnetic fields, which stimulates phase transformation in the hydrogels to fill or heal the hydrogels. In addition, the hydrogel systems were demonstrated with high biocompatibility and plasticity. These features of magnetic self-healable structural color hydrogels make them have broad application prospects in the fields of biological engineering and cell engineering.
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http://dx.doi.org/10.1021/acsami.9b22579DOI Listing
February 2020

Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1).

FASEB J 2020 01 2;34(1):1591-1601. Epub 2019 Dec 2.

Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.

The Slack (KCNT1) gene encodes sodium-activated potassium channels that are abundantly expressed in the central nervous system. Human mutations alter the function of Slack channels, resulting in epilepsy and intellectual disability. Most of the disease-causing mutations are located in the extended cytoplasmic C-terminus of Slack channels and result in increased Slack current. Previous experiments have shown that the C-terminus of Slack channels binds a number of cytoplasmic signaling proteins. One of these is Phactr1, an actin-binding protein that recruits protein phosphatase 1 (PP1) to certain phosphoprotein substrates. Using co-immunoprecipitation, we found that Phactr1 is required to link the channels to actin. Using patch clamp recordings, we found that co-expression of Phactr1 with wild-type Slack channels reduces the current amplitude but has no effect on Slack channels in which a conserved PKC phosphorylation site (S407) that regulates the current amplitude has been mutated. Furthermore, a Phactr1 mutant that disrupts the binding of PP1 but not that of actin fails to alter Slack currents. Our data suggest that Phactr1 regulates the Slack by linking PP1 to the channel. Targeting Slack-Phactr1 interactions may therefore be helpful in developing the novel therapies for brain disorders associated with the malfunction of Slack channels.
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http://dx.doi.org/10.1096/fj.201902366RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956700PMC
January 2020

Prevalence and protective factors of HIV and syphilis infection among men who have sex with men in Northwest China.

J Med Virol 2020 08 18;92(8):1141-1147. Epub 2019 Nov 18.

Department of HIV Testing Mobilization, Xi'an Center for Marie Stopes International, Xi'an, China.

Background: Men who have sex with men (MSM) continue to be disproportionately impacted by human immunodeficiency virus (HIV) and syphilis in China. Little is known about HIV and syphilis infections among MSM in Xi'an, a developing city in Northwest China. A cross-sectional study with recruitment via snowball sampling was conducted to collect HIV and syphilis infection status and risk factors among MSM in Xi'an between April 2013 to December 2016. Among the 5000 participants, the mean age was 29.0 years (SD 7.7) and the prevalence of HIV, syphilis, and coinfection was 6.5%, 2.2%, and 0.4%, respectively. There was no significant change in HIV prevalence from 2013 to 2016, while the prevalence of syphilis and coinfection showed a downward trend. Multiple logistic regression analyses found that being over 25 years old (OR = 1.647), junior high school/middle school education and below (OR = 3.085), with a sexual role of passive or versatile (OR = 3.300; OR = 2.337), rush poppers use during the last 6 months (OR = 1.660) and syphilis infection (OR = 2.235) were more likely to acquire HIV infection, whereas used condoms in the last episode of anal sex (OR = 0.572) and tested HIV antibody previously (OR = 0.252) were protective factors for HIV infection. HIV prevalence among MSM in Xi'an was stable, whereas the prevalence of syphilis and coinfection showed a downward trend. Interventions to promote HIV and sexually transmitted disease testing and condom use should be strengthened, especially for MSM with low education.
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http://dx.doi.org/10.1002/jmv.25622DOI Listing
August 2020

Red-crowned crane () prefers postharvest reed beds during winter period in Yancheng National Nature Reserve.

PeerJ 2019 13;7:e7682. Epub 2019 Sep 13.

Nanjing Forestry University, College of Biology and the Environment, Nanjing, Jiangsu, China.

Reed beds represent an important habitat for the survival of birds by providing favorable foraging and reproduction conditions. Reed management, as a traditional agricultural activity, primarily includes water level control and vegetation removal by cutting. Red-crowned crane () is one of the most endangered cranes, and their population continues to decline due to habitat loss caused by artificial activities. A lack of research relating to how reed management affects crane habitat distribution patterns throughout the wintering period hinders our ability to offer conservation recommendations. In the present study, we explored the effect of reed management on the habitat distribution patterns and analyzed the food resources of red-crowned crane in the Yancheng National Nature Reserve (YNNR). According to the reed management activities in December, we divided the wintering period into two phases: the preharvest period and the postharvest period. Throughout the wintering period, the number of cranes recorded in the common seepweed () tidal flats remained stable, but cranes were rarely recorded in the smooth cordgrass () tidal flats and aquaculture fish ponds. The number of cranes, however, showed a noticeable fluctuation in the reed beds during the two periods. Before the reed harvest, only a small proportion of cranes were recorded in the reed beds (relative abundance = 2.9%). However, more cranes (relative abundance = 61.0%) were recorded after the reed harvest. Water was introduced from adjacent rivers and fish ponds to submerge the cut reed beds. Changes in potential animal food resources (items and biomass) might be one of the vital reasons for the preference of cranes to the postharvest reed beds. Our results suggest that traditional reed management in the YNNR could benefit this flagship crane species that winters in the wetland system. However, as reed harvest has been forbidden in the core zone for conservation purposes since 2016, further research is needed to verify whether forbidding the harvest of reeds is reasonable.
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http://dx.doi.org/10.7717/peerj.7682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746218PMC
September 2019

Compositional Control in 2D Perovskites with Alternating Cations in the Interlayer Space for Photovoltaics with Efficiency over 18.

Adv Mater 2019 Nov 15;31(44):e1903848. Epub 2019 Sep 15.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, and Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an, 710119, China.

2D perovskites stabilized by alternating cations in the interlayer space (ACI) represent a very new entry as highly efficient semiconductors for solar cells approaching 15% power conversion efficiency (PCE). However, further improvements will require understanding of the nature of the films, e.g., the thickness distribution and charge-transfer characteristics of ACI quantum wells (QWs), which are currently unknown. Here, efficient control of the film quality of ACI 2D perovskite (GA)(MA) Pb I (〈n〉 = 3) QWs via incorporation of methylammonium chloride as an additive is demonstrated. The morphological and optoelectronic characterizations unambiguously demonstrate that the additive enables a larger grain size, a smoother surface, and a gradient distribution of QW thickness, which lead to enhanced photocurrent transport/extraction through efficient charge transfer between low-n and high-n QWs and suppressed nonradiative charge recombination. Therefore, the additive-treated ACI perovskite film delivers a champion PCE of 18.48%, far higher than the pristine one (15.79%) due to significant improvements in open-circuit voltage and fill factor. This PCE also stands as the highest value for all reported 2D perovskite solar cells based on the ACI, Ruddlesden-Popper, and Dion-Jacobson families. These findings establish the fundamental guidelines for the compositional control of 2D perovskites for efficient photovoltaics.
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http://dx.doi.org/10.1002/adma.201903848DOI Listing
November 2019

Interfacial Engineering at the 2D/3D Heterojunction for High-Performance Perovskite Solar Cells.

Nano Lett 2019 10 11;19(10):7181-7190. Epub 2019 Sep 11.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering , Shaanxi Normal University , Xi'an 710119 , China.

Perovskite solar cells based on two-dimensional/three-dimensional (2D/3D) hierarchical structure have attracted significant attention in recent years due to their promising photovoltaic performance and stability. However, obtaining a detailed understanding of interfacial mechanism at the 2D/3D heterojunction, for example, the ligand-chemistry-dependent nature of the 2D/3D heterojunction and its influence on charge collection and the final photovoltaic outcome, is not yet fully developed. Here we demonstrate the underlying 3D phase templates growth of quantum wells (QWs) within a 2D capping layer, which is further influenced by the fluorination of spacers and compositional engineering in terms of thickness distribution and orientation. Better QW alignment and faster dynamics of charge transfer at the 2D/3D heterojunction result in higher charge mobility and lower charge recombination loss, largely explaining the significant improvements in charge collection and open-circuit voltage () in complete solar cells. As a result, 2D/3D solar cells with a power-conversion efficiency of 21.15% were achieved, significantly higher than the 3D counterpart (19.02%). This work provides key missing information on how interfacial engineering influences the desirable electronic properties of the 2D/3D hierarchical films and device performance via ligand chemistry and compositional engineering in the QW layer.
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http://dx.doi.org/10.1021/acs.nanolett.9b02781DOI Listing
October 2019

Multifunctional Magnetic Copper Ferrite Nanoparticles as Fenton-like Reaction and Near-Infrared Photothermal Agents for Synergetic Antibacterial Therapy.

ACS Appl Mater Interfaces 2019 Sep 21;11(35):31649-31660. Epub 2019 Aug 21.

College of Food Science and Engineering , Northwest A&F University , Yangling 712100 , Shaanxi , China.

Synergistic therapeutic strategies for bacterial infection have attracted extensive attentions owing to their enhanced therapeutic effects and less adverse effects compared with monotherapy. Herein, we report a novel synergistic antibacterial platform that integrates the nanocatalytic antibacterial therapy and photothermal therapy (PTT) by hemoglobin-functionalized copper ferrite nanoparticles (Hb-CFNPs). In the presence of a low concentration of hydrogen peroxide (HO), the excellent Fenton and Fenton-like reaction activity of Hb-CFNPs can effectively catalyze the decomposition of HO to produce hydroxyl radicals (·OH), rendering an increase in the permeability of the bacterial cell membrane and the sensitivity to heat. With the assistance of NIR irradiation, hyperthermia generated by Hb-CFNPs can induce the death of the damaged bacteria. Additionally, owing to the outstanding magnetic property of Hb-CFNPs, it can improve the photothermal efficiency by about 20 times via magnetic enrichment, which facilitates to realize excellent bactericidal efficacy at a very low experimental dose (20 μg/mL). In vitro antibacterial experiment shows that this synergistic antibacterial strategy has a broad-spectrum antibacterial property against Gram-negative (, 100%) and Gram-positive (, 96.4%). More importantly, in vivo -infected abscess treatment studies indicate that Hb-CFNPs can serve as an antibacterial candidate with negligible toxicity to realize synergistic treatment of bacterial infections through catalytic and photothermal effects. Accordingly, this study proposes a novel, high-efficiency, and multifunctional therapeutic system for the treatment of bacterial infection, which will open up a new avenue for the design of synergistic antibacterial systems in the future.
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http://dx.doi.org/10.1021/acsami.9b10096DOI Listing
September 2019