Yajun Duan

Yajun Duan

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Yajun Duan

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Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.

Biomed Pharmacother 2019 Oct 31;118:109389. Epub 2019 Aug 31.

Department of Biochemistry and Molecular Biology, College of Life Science, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China; Department of Pharmacological Sciences, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2019.109389DOI Listing
October 2019

Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner.

Biochem Biophys Res Commun 2019 Sep 24. Epub 2019 Sep 24.

Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.09.084DOI Listing
September 2019

LongShengZhi Capsule reduces carrageenan-induced thrombosis by reducing activation of platelets and endothelial cells.

Pharmacol Res 2019 Jun 12;144:167-180. Epub 2019 Apr 12.

Department of Pharmacological Sciences, Key Laboratory of Major Metabolic Diseases and Nutritional Regulation of Anhui Department of Education, Hefei University of Technology, Hefei, China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.04.013DOI Listing
June 2019

Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.

Bioorg Med Chem Lett 2019 May 27;29(9):1090-1093. Epub 2019 Feb 27.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.02.030DOI Listing
May 2019

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.

Bioorg Med Chem Lett 2019 Apr 8;29(8):1012-1018. Epub 2019 Feb 8.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui 230009, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.02.008DOI Listing
April 2019

The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule.

Pharmacol Res 2019 03 17;141:409-417. Epub 2019 Jan 17.

Department of Pharmacological Sciences, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183166
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http://dx.doi.org/10.1016/j.phrs.2019.01.024DOI Listing
March 2019

Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.

Biochem Biophys Res Commun 2018 12 5;506(4):1040-1046. Epub 2018 Nov 5.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183239
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http://dx.doi.org/10.1016/j.bbrc.2018.10.198DOI Listing
December 2018

CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells.

Oncogenesis 2018 Dec 21;7(12):98. Epub 2018 Dec 21.

School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.

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http://dx.doi.org/10.1038/s41389-018-0107-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302092PMC
December 2018

Inhibition of Vascular Calcification.

Arterioscler Thromb Vasc Biol 2018 10;38(10):2382-2395

the Department of Biomedical Sciences, College of Biomedical Engineering, Hefei University of Technology, Hefei, China (X.Y., Y.D., Y.L., H.H., Y.C., J.H.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311546
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http://dx.doi.org/10.1161/ATVBAHA.118.311546DOI Listing
October 2018

Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.

Breast Cancer Res 2018 09 12;20(1):112. Epub 2018 Sep 12.

Division of Pediatric Surgery, Department of Surgery, Children's Research Institute, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, USA.

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http://dx.doi.org/10.1186/s13058-018-1028-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134690PMC
September 2018

NaoXinTong Capsule Inhibits Carrageenan-Induced Thrombosis in Mice.

J Cardiovasc Pharmacol 2018 07;72(1):49-59

Department of Biomedical Sciences College of Biomedical Engineering, Hefei University of Technology, Hefei, China.

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http://dx.doi.org/10.1097/FJC.0000000000000592DOI Listing
July 2018

Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.

Cancer Lett 2018 04 2;419:233-244. Epub 2018 Feb 2.

Division of Pediatric Surgery, Department of Surgery, Children's Research Institute, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, USA; Divisions of Pediatric Pathology, Department of Pathology, Children's Research Institute, Medical College of Wisconsin, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.01.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821135PMC
April 2018

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

J Lipid Res 2018 03 3;59(3):439-451. Epub 2018 Jan 3.

Department of Biomedical Sciences, College of Biomedical Engineering, Hefei University of Technology, Hefei, China

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http://dx.doi.org/10.1194/jlr.M080440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832929PMC
March 2018

Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Feb 5;1863(2):177-190. Epub 2017 Dec 5.

College of Biomedical Engineering, Hefei University of Technology, Hefei, China; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China; College of Life Sciences, Nankai University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752432PMC
February 2018

Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice.

Arterioscler Thromb Vasc Biol 2017 07 25;37(7):1290-1300. Epub 2017 May 25.

From the Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China (L.S., Q.L., P.Z., Y. Liu, L.L., M.Y., C.M., X.L., Y. Li); Department of Biomedical Sciences, College of Biomedical Engineering, Hefei University of Technology, China (X.Y., Y.C., J.H., Y.D.); Department of Physiology, Tianjin Medical University, China (R.Z.); Department of Pharmacology, Tianjin University of Traditional Chinese Medicine, China (Y.Z.); Departments of Surgery and Pathology, Medical College of Wisconsin, Milwaukee, WI (Q.R.M.); and Department of Biochemistry and Molecular Biology, College of Life Sciences, The State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China (J.H., Y.D.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309630DOI Listing
July 2017

Inhibition of glutathione production by L-S,R-buthionine sulfoximine activates hepatic ascorbate synthesis - A unique anti-oxidative stress mechanism in mice.

Biochem Biophys Res Commun 2017 02 20;484(1):56-63. Epub 2017 Jan 20.

College of Biomedical Engineering, Hefei University of Technology, Hefei, China; College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.01.072DOI Listing
February 2017

Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice.

J Ethnopharmacol 2017 Feb 21;198:479-488. Epub 2017 Jan 21.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.01.040DOI Listing
February 2017

NaoXinTong Enhances Atorvastatin-induced Plaque Stability While Ameliorating Atorvastatin-induced Hepatic Inflammation.

J Cardiovasc Pharmacol 2017 Jan;69(1):55-64

*College of Life Sciences, Nankai University, Tianjin, China; †College of Biomedical Engineering, Hefei University of Technology, Hefei, China; ‡School of Medicine, Nankai University, Tianjin, China; and §Buchang Pharmaceutical Co Ltd, Xi'an, China.

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http://dx.doi.org/10.1097/FJC.0000000000000441DOI Listing
January 2017

MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.

Biochim Biophys Acta 2016 09 27;1861(9 Pt A):1180-1191. Epub 2016 Jun 27.

College of Biomedical Engineering, Hefei University of Technology, Hefei, China; College of Life Sciences, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Biotherapy, Nankai University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.06.017DOI Listing
September 2016

Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM.

J Biol Chem 2016 08 29;291(33):16977-89. Epub 2016 Jun 29.

From the College of Life Sciences, the College of Biomedical Engineering, Hefei University of Technology, Hefei 230009, and the State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Biotherapy, Nankai University, Tianjin 300071,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.740092
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http://dx.doi.org/10.1074/jbc.M116.740092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016103PMC
August 2016

Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE.

J Biol Chem 2016 07 12;291(29):15108-18. Epub 2016 May 12.

the College of Biomedical Engineering, Hefei University of Technology, Hefei 230000, China College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Biotherapy, Nankai University, Tianjin 300071, China and

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http://dx.doi.org/10.1074/jbc.M116.726737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946927PMC
July 2016

MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes.

Biochem Biophys Res Commun 2016 05 1;473(4):939-946. Epub 2016 Apr 1.

College of Medical Engineering, Hefei University of Technology, Hefei, China; School of Medicine, Nankai University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.03.156DOI Listing
May 2016

NaoXinTong Inhibits the Advanced Atherosclerosis and Enhances the Plaque Stability in Apolipoprotein E Deficient Mice.

J Cardiovasc Pharmacol 2016 Mar;67(3):203-11

*College of Life Sciences, Nankai University, Tianjin, China; †Buchang Pharmaceutical Co, Ltd, Xi'an, China; ‡College of Medical Engineering, Hefei University of Technology, Hefei, China; §Collaborative Innovation Center for Biotherapy, School of Medicine, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1097/FJC.0000000000000334DOI Listing
March 2016

Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice.

Biochem Biophys Res Commun 2016 Jan 22;469(3):456-62. Epub 2015 Nov 22.

College of Medical Engineering, Hefei University of Technology, Hefei, China; College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Biotherapy, Nankai University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.11.064DOI Listing
January 2016

Co-treatment of Pitavastatin and Dexamethasone Exacerbates the High-fat Diet-induced Atherosclerosis in apoE-deficient Mice.

J Cardiovasc Pharmacol 2015 Aug;66(2):189-95

*State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; †College of Life Sciences, Nankai University, Tianjin, China; ‡Medical College of Wisconsin, Milwaukee, WI; §Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China; and ‖School of Medicine, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1097/FJC.0000000000000264DOI Listing
August 2015

Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.

J Biol Chem 2015 Jun 25;290(23):14418-29. Epub 2015 Apr 25.

From the State Key Laboratory of Medicinal Chemical Biology, Colleges of Life Sciences and Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin 300071, China,

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http://www.jbc.org/content/290/23/14418.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.643015
Publisher Site
http://dx.doi.org/10.1074/jbc.M115.643015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505509PMC
June 2015

Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.

Sci Rep 2015 Jun 10;5:11219. Epub 2015 Jun 10.

1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China [2] Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin 300071, China.

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http://dx.doi.org/10.1038/srep11219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462147PMC
June 2015

Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression.

Biochim Biophys Acta 2015 May 19;1852(5):1038-48. Epub 2015 Feb 19.

State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; College of Life Sciences, Nankai University, Tianjin, China; Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.02.006DOI Listing
May 2015

Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice.

Arterioscler Thromb Vasc Biol 2015 Apr 19;35(4):948-59. Epub 2015 Feb 19.

From the State Key Laboratory of Medicinal Chemical Biology (Y.C., Y.D., J.H.), Collaborative Innovation Center of Biotherapy (Y.C., Y.D., R.X., J.H.), College of Life Sciences (Y.D., X.Y., L.S., M.L., Q.W., X.M., W.Z., X.L., J.H.), Nankai University, Tianjin, China; Department of Surgery, Medical College of Wisconsin, Milwaukee (W.H., R.Q.M.); and Department of Pathology, Weill Medical College of Cornell University, New York, NY (D.P.H.).

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http://dx.doi.org/10.1161/ATVBAHA.114.305116DOI Listing
April 2015

NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice.

Evid Based Complement Alternat Med 2015 3;2015:242517. Epub 2015 Mar 3.

State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China ; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China ; Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin 300071, China.

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http://www.hindawi.com/journals/ecam/2015/242517/
Publisher Site
http://dx.doi.org/10.1155/2015/242517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363582PMC
March 2015

Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.

Int J Cancer 2015 Feb 28;136(4):771-83. Epub 2014 Jun 28.

State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; College of Life Sciences, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1002/ijc.29038DOI Listing
February 2015

Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice.

J Cardiovasc Pharmacol 2014 May;63(5):441-52

*State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; †College of Life Sciences, Nankai University, Tianjin, China; ‡Buchang Pharmaceutical Co, Ltd, Xi'an, China; §Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; and ¶Collaborative Innovation Center of Biotherapy, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1097/FJC.0000000000000067DOI Listing
May 2014

Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways.

Biochem J 2013 Sep;454(3):467-77

The State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 30071, China.

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http://dx.doi.org/10.1042/BJ20130580DOI Listing
September 2013

Activation of liver X receptor induces macrophage interleukin-5 expression.

J Biol Chem 2012 Dec 13;287(52):43340-50. Epub 2012 Nov 13.

State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.

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http://dx.doi.org/10.1074/jbc.M112.403394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527921PMC
December 2012

Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages.

Atherosclerosis 2012 Jun 27;222(2):434-43. Epub 2012 Mar 27.

College of Life Sciences, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.03.007DOI Listing
June 2012

Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen.

Atherosclerosis 2011 Oct 18;218(2):435-42. Epub 2011 Jul 18.

College of Life Sciences, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.06.048DOI Listing
October 2011

Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery.

J Biomed Mater Res A 2011 Jan 9;96(1):212-20. Epub 2010 Nov 9.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1002/jbm.a.32962DOI Listing
January 2011

Novel peptide-dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer.

Int J Nanomedicine 2010 Dec 22;6:59-69. Epub 2010 Dec 22.

The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjian, People's Republic of China.

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http://www.dovepress.com/novel-peptidendashdendrimer-conjuga
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http://dx.doi.org/10.2147/IJN.S14601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025585PMC
December 2010

Poly(ethylene glycol) analogs grafted with low molecular weight poly(ethylene imine) as non-viral gene vectors.

Acta Biomater 2010 Jul 28;6(7):2650-7. Epub 2010 Jan 28.

The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, PR China.

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http://dx.doi.org/10.1016/j.actbio.2010.01.022DOI Listing
July 2010

Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer.

Mol Ther 2010 May 23;18(5):1010-8. Epub 2010 Feb 23.

Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1038/mt.2010.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890122PMC
May 2010

Poly(ethylene glycol)-grafted polyethylenimine modified with G250 monoclonal antibody for tumor gene therapy.

Hum Gene Ther 2010 Feb;21(2):191-8

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1089/hum.2009.010DOI Listing
February 2010

Polyamidoamine dendrimers with a modified Pentaerythritol core having high efficiency and low cytotoxicity as gene carriers.

Biomacromolecules 2009 Mar;10(3):617-22

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1021/bm801333sDOI Listing
March 2009

A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy.

J Control Release 2008 Apr 8;127(2):173-9. Epub 2008 Feb 8.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China.

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http://dx.doi.org/10.1016/j.jconrel.2008.01.016DOI Listing
April 2008