Yael P Mosse

Yael P Mosse

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Yael P Mosse

Yael P Mosse

Publications by authors named "Yael P Mosse"

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48Publications

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Thrown for a Loop: Awakening BORIS to Evade ALK Inhibition Therapy.

Cancer Cell 2019 Oct;36(4):345-347

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.09.009DOI Listing
October 2019

Computational algorithms for in silico profiling of activating mutations in cancer.

Cell Mol Life Sci 2019 Jul 13;76(14):2663-2679. Epub 2019 Apr 13.

Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00018-019-03097-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589134PMC
July 2019

Outcomes After Proton Therapy for Treatment of Pediatric High-Risk Neuroblastoma.

Int J Radiat Oncol Biol Phys 2019 Jun 7;104(2):401-408. Epub 2019 Feb 7.

Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193019
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http://dx.doi.org/10.1016/j.ijrobp.2019.01.095DOI Listing
June 2019

An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma.

Sci Transl Med 2019 03;11(483)

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aau9732DOI Listing
March 2019

Differences in Genomic Profiles and Outcomes between Thoracic and Adrenal Neuroblastoma.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Childrens Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1093/jnci/djz027DOI Listing
February 2019

Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study.

J Clin Oncol 2017 Oct 8;35(28):3215-3221. Epub 2017 Aug 8.

Yael P. Mossé, Megan S. Lim, Delphine Rolland, Elizabeth Fox, and Peter Adamson, University of Pennsylvania, Philadelphia, PA; Stephan D. Voss, Harvard Medical School, Boston, MA; Charles G. Minard and Susan M. Blaney, Baylor College of Medicine, Houston, TX; Keith Wilner, Pfizer Oncology, La Jolla, CA; and Brenda J. Weigel, University of Minnesota Cancer Center, Minneapolis, MN.

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http://dx.doi.org/10.1200/JCO.2017.73.4830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617123PMC
October 2017

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial.

J Clin Oncol 2016 Apr 16;34(12):1368-75. Epub 2016 Feb 16.

Steven G. DuBois, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA; Araz Marachelian, Susan Groshen, Jemily Malvar, Hollie Lai, Fariba Goodarzian, Hiroyuki Shimada, Scarlett Czarnecki, and Denice Tsao-Wei, University of Southern California Keck School of Medicine and Children's Hospital Los Angeles, Los Angeles; Randall Hawkins, Jesse Courtier, and Katherine K. Matthay, University of California, San Francisco, School of Medicine and Benioff Children's Hospital, San Francisco, CA; Elizabeth Fox, Rochelle Bagatell, John M. Maris, and Yael P. Mosse, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Rachel A. Kudgus and Joel M. Reid, Mayo Clinic, Rochester, MN; and Lars Wagner, University of Kentucky College of Medicine, Lexington, KY.

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http://jco.ascopubs.org/content/early/2016/02/11/JCO.2015.65
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.65.4889
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http://dx.doi.org/10.1200/JCO.2015.65.4889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872349PMC
April 2016

Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma.

Clin Cancer Res 2016 Feb 5;22(4):948-60. Epub 2015 Oct 5.

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755925PMC
February 2016

Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies.

Authors:
Yael P Mossé

Clin Cancer Res 2016 Feb 26;22(3):546-52. Epub 2015 Oct 26.

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://clincancerres.aacrjournals.org/content/early/2015/10/
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http://clincancerres.aacrjournals.org/content/early/2016/01/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-1100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738092PMC
February 2016

The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma.

Cancer Discov 2016 Jan 10;6(1):96-107. Epub 2015 Nov 10.

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://cancerdiscovery.aacrjournals.org/content/early/2015/1
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-15-1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707106PMC
January 2016

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.

Cancer Cell 2014 Nov 10;26(5):682-94. Epub 2014 Nov 10.

Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269829PMC
November 2014

Dielectrophoretic capture and genetic analysis of single neuroblastoma tumor cells.

Front Oncol 2014 31;4:201. Epub 2014 Jul 31.

Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia , Philadelphia, PA , USA ; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA , USA.

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https://www.frontiersin.org/articles/10.3389/fonc.2014.00201
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http://journal.frontiersin.org/article/10.3389/fonc.2014.002
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http://dx.doi.org/10.3389/fonc.2014.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116800PMC
August 2014

Neuroblastoma in older children, adolescents and young adults: a report from the International Neuroblastoma Risk Group project.

Pediatr Blood Cancer 2014 Apr 13;61(4):627-35. Epub 2013 Sep 13.

Division of Oncology, Children's Hospital of Philadelphia and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.24777DOI Listing
April 2014

Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.

Lancet Oncol 2013 May 16;14(6):472-80. Epub 2013 Apr 16.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, and Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(13)70095-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730818PMC
May 2013

Pediatric phase I trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: a Children's Oncology Group Phase I Consortium study.

Clin Cancer Res 2012 Nov 17;18(21):6058-64. Epub 2012 Sep 17.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008248PMC
November 2012

Targeting ALK in neuroblastoma--preclinical and clinical advancements.

Nat Rev Clin Oncol 2012 May 15;9(7):391-9. Epub 2012 May 15.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/nrclinonc.2012.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683972PMC
May 2012

Safety and efficacy of tandem 131I-metaiodobenzylguanidine infusions in relapsed/refractory neuroblastoma.

Pediatr Blood Cancer 2011 Dec 14;57(7):1124-9. Epub 2011 Apr 14.

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/pbc.23062DOI Listing
December 2011

Inhibition of ALK signaling for cancer therapy.

Clin Cancer Res 2009 Sep 8;15(18):5609-14. Epub 2009 Sep 8.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.

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http://clincancerres.aacrjournals.org/content/15/18/5609.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-08-2762DOI Listing
September 2009

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy.

Genome Res 2009 Feb 13;19(2):276-83. Epub 2009 Jan 13.

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1101/gr.075671.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652209PMC
February 2009

Identification of ALK as a major familial neuroblastoma predisposition gene.

Nature 2008 Oct 24;455(7215):930-5. Epub 2008 Aug 24.

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature07261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672043PMC
October 2008

Effect of sleep stage on breathing in children with central hypoventilation.

J Appl Physiol (1985) 2008 Jul 22;105(1):44-53. Epub 2008 May 22.

Sleep Center, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1152/japplphysiol.01269.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494838PMC
July 2008

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.

Mol Cancer Res 2008 May;6(5):735-42

Division of Oncology, Children's Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760152PMC
May 2008

Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression.

Genes Chromosomes Cancer 2007 Oct;46(10):936-49

Division of Oncology, Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1002/gcc.20477
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http://dx.doi.org/10.1002/gcc.20477DOI Listing
October 2007

Chromosome 1p and 11q deletions and outcome in neuroblastoma.

N Engl J Med 2005 Nov;353(21):2243-53

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104-4318, USA.

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http://dx.doi.org/10.1056/NEJMoa052399DOI Listing
November 2005

Measurement and relevance of neuroblastoma DNA copy number changes in the post-genome era.

Cancer Lett 2005 Oct;228(1-2):83-90

Division of Oncology, Children's Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Blvd, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1016/j.canlet.2005.02.052DOI Listing
October 2005

High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.

Genes Chromosomes Cancer 2005 Aug;43(4):390-403

Division of Oncology, Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1002/gcc.20198DOI Listing
August 2005