Publications by authors named "Yadong Huang"

100Publications

Regulation of lipid droplets via the PLCβ2-PKCα-ADRP pathway in granulosa cells exposed to cadmium.

Environ Pollut 2020 Dec 27;267:115541. Epub 2020 Aug 27.

Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China; Guangzhou Biopharmaceutical R&D Center of Jinan University Co.,Ltd, Guangzhou, 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2020.115541DOI Listing
December 2020

Hybrid Freeze-Dried Dressings Composed of Epidermal Growth Factor and Recombinant Human-Like Collagen Enhance Cutaneous Wound Healing in Rats.

Front Bioeng Biotechnol 2020 15;8:742. Epub 2020 Jul 15.

Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.3389/fbioe.2020.00742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375021PMC
July 2020

Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules.

Stem Cell Reports 2020 08 30;15(2):408-423. Epub 2020 Jul 30.

Department of Cell Biology, Jinan University, Guangzhou 510632, China; Department of Pharmacology, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Bioengineering Medicine of, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419716PMC
August 2020

In Vivo Chimeric Alzheimer's Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons.

Cell Rep 2020 Jul;32(4):107962

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Center for Translational Advancement, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430173PMC
July 2020

A Testis-Derived Hydrogel as an Efficient Feeder-Free Culture Platform to Promote Mouse Spermatogonial Stem Cell Proliferation and Differentiation.

Front Cell Dev Biol 2020 19;8:250. Epub 2020 May 19.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.3389/fcell.2020.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248195PMC
May 2020

Epidermal growth factor regulates the development of stem and progenitor Leydig cells in rats.

J Cell Mol Med 2020 Jul 22;24(13):7313-7330. Epub 2020 May 22.

Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.1111/jcmm.15302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339176PMC
July 2020

A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer.

Int J Nanomedicine 2020 1;15:3087-3098. Epub 2020 May 1.

School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, People's Republic of China.

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http://dx.doi.org/10.2147/IJN.S241324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200237PMC
July 2020

Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease.

Cell Stem Cell 2020 03;26(3):297-299

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.02.004DOI Listing
March 2020

Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.

Cell Rep 2019 11;29(8):2123-2133.e4

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437815PMC
November 2019

An Alzheimer's-disease-protective APOE mutation.

Nat Med 2019 11;25(11):1648-1649

Gladstone Institute of Neurological Disease, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41591-019-0634-9DOI Listing
November 2019

aFGF Promotes Neurite Growth by Regulating GSK3β-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-β.

J Alzheimers Dis 2019 ;72(1):97-109

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.3233/JAD-190458DOI Listing
November 2020

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease.

Mol Neurodegener 2019 06 11;14(1):24. Epub 2019 Jun 11.

Gladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1186/s13024-019-0324-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558779PMC
June 2019

Identification and functional characterization of microRNAs in rat Leydig cells during development from the progenitor to the adult stage.

Mol Cell Endocrinol 2019 08 23;493:110453. Epub 2019 May 23.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou, China; Biopharmaceutical Research and Development Center, Jinan University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2019.110453DOI Listing
August 2019

Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway.

Chemosphere 2019 Jun 15;225:765-774. Epub 2019 Mar 15.

Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, China; National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, 510632, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193053
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http://dx.doi.org/10.1016/j.chemosphere.2019.03.094DOI Listing
June 2019

Flame-Retardant Mechanism of Layered Double Hydroxides in Asphalt Binder.

Materials (Basel) 2019 Mar 8;12(5). Epub 2019 Mar 8.

College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, China.

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http://dx.doi.org/10.3390/ma12050801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427306PMC
March 2019

Toxicology study of long-term administration of rhKGF-2 eye drops on rabbit corneas.

Regul Toxicol Pharmacol 2019 Apr 5;103:189-195. Epub 2019 Feb 5.

Wenzhou Medical University, Chashan University Park, Wenzhou, 325035, China. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2019.02.002DOI Listing
April 2019

Lasing-Mode Switch of a Hexagonal ZnO Pyramid Driven by Pressure within a Diamond Anvil Cell.

J Phys Chem Lett 2019 Feb 28;10(3):610-616. Epub 2019 Jan 28.

State Key Laboratory of Superhard Materials, College of Physics , Jilin University , Changchun 130012 , China.

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http://pubs.acs.org/doi/10.1021/acs.jpclett.8b03748
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http://dx.doi.org/10.1021/acs.jpclett.8b03748DOI Listing
February 2019

Pilot-scale expression, purification, and bioactivity of recombinant human TGF-β from Escherichia coli.

Eur J Pharm Sci 2019 Jan 10;127:225-232. Epub 2018 Nov 10.

Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, PR China.

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183050
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http://dx.doi.org/10.1016/j.ejps.2018.11.009DOI Listing
January 2019

Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1.

Front Endocrinol (Lausanne) 2018 29;9:644. Epub 2018 Oct 29.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Department of Cell Biology, Jinan University, Guangzhou, China.

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https://www.frontiersin.org/article/10.3389/fendo.2018.00644
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http://dx.doi.org/10.3389/fendo.2018.00644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216111PMC
October 2018

Determinants of Health Care-Seeking Delay among Tuberculosis Patients in Rural Area of Central China.

Int J Environ Res Public Health 2018 09 13;15(9). Epub 2018 Sep 13.

Institute of Infectious Diseases, Hubei Center for Disease Control and Prevention, Wuhan 430079, China.

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http://dx.doi.org/10.3390/ijerph15091998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164791PMC
September 2018

Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice.

EBioMedicine 2018 Sep 18;35:295-306. Epub 2018 Aug 18.

Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China; Department of Pharmacology, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161474PMC
September 2018

Hormonal changes and folliculogenesis in female offspring of rats exposed to cadmium during gestation and lactation.

Environ Pollut 2018 Jul 22;238:336-347. Epub 2018 Mar 22.

Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China; National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2018.03.023DOI Listing
July 2018

Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes.

Mol Med Rep 2017 Nov 22;16(5):5924-5930. Epub 2017 Aug 22.

Jiangsu Food and Pharmaceutical Science College, Huai'an, Jiangsu 223003, P.R. China.

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http://dx.doi.org/10.3892/mmr.2017.7330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865770PMC
November 2017

Tat-haFGF Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.

Mol Ther Nucleic Acids 2017 Jun 10;7:439-452. Epub 2017 May 10.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China; Cell Biology Department and National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443968PMC
June 2017

Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy.

Steroids 2017 05 4;121:10-16. Epub 2017 Mar 4.

Institute of Materia Medica and Guangdong Provincial Key Laboratory of New Pharmaceutical Dosage Form, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2017.02.003DOI Listing
May 2017

Approaching Alzheimer's disease from a network level.

Oncotarget 2017 Feb;8(6):9003-9004

Department of Neurology, Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.14617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354704PMC
February 2017

Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors.

Stem Cell Reports 2017 01 22;8(1):39-53. Epub 2016 Dec 22.

Department of Cell Biology, Jinan University, Guangzhou 510632, China; Department of Pharmacology, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(16)3027
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http://www.cell.com/cms/attachment/2076970653/2070564998/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221367111630272
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http://dx.doi.org/10.1016/j.stemcr.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233410PMC
January 2017

Glycidamide inhibits progesterone production through reactive oxygen species-induced apoptosis in R2C Rat Leydig Cells.

Food Chem Toxicol 2017 Oct 28;108(Pt B):563-570. Epub 2016 Oct 28.

Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou, 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.09.035DOI Listing
October 2017

Production of human type II collagen using an efficient baculovirus-silkworm multigene expression system.

Mol Genet Genomics 2016 Dec 26;291(6):2189-2198. Epub 2016 Sep 26.

Subtropical Sericulture and Mulberry Resources Protection and Safety Engineering Research Center, Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.

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http://dx.doi.org/10.1007/s00438-016-1251-7DOI Listing
December 2016

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Stem Cell Reports 2016 09 1;7(3):325-340. Epub 2016 Sep 1.

Department of Neurology, Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032560PMC
September 2016

The 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against the insulin resistance and hepatic steatosis in db/db mice.

Eur J Pharmacol 2016 Oct 27;788:140-151. Epub 2016 May 27.

Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.05.034DOI Listing
October 2016

Differential transcriptomic responses to Fusarium graminearum infection in two barley quantitative trait loci associated with Fusarium head blight resistance.

BMC Genomics 2016 05 21;17:387. Epub 2016 May 21.

Department of Agronomy and Plant Genetics, University of Minnesota, St. Paul, MN 55108, USA.

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http://dx.doi.org/10.1186/s12864-016-2716-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875680PMC
May 2016

Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples.

Neuron 2016 05 5;90(4):740-51. Epub 2016 May 5.

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA; Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097044PMC
May 2016

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.

Cell Stem Cell 2016 05 28;18(5):653-67. Epub 2016 Apr 28.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30009-1
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http://www.cell.com/cms/attachment/2054871000/2060868183/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S193459091630009
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http://dx.doi.org/10.1016/j.stem.2016.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864020PMC
May 2016

Prevention of gastrointestinal lead poisoning using recombinant Lactococcus lactis expressing human metallothionein-I fusion protein.

Sci Rep 2016 Apr 5;6:23716. Epub 2016 Apr 5.

Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, P.R. China.

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http://dx.doi.org/10.1038/srep23716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820694PMC
April 2016

Intranasal TAT-haFGF Improves Cognition and Amyloid-β Pathology in an AβPP/PS1 Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2016 ;51(4):985-90

Institute of Biomedicine & Department of Cell Biology, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.3233/JAD-151121DOI Listing
December 2016

Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.

J Neurosci 2016 Feb;36(7):2316-22

Gladstone Institute of Neurological Disease, San Francisco, California 94158, and Biomedical Sciences Graduate Program, and Departments of Neurology and Pathology, University of California, San Francisco, California 94143

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http://www.jneurosci.org/content/36/7/2316.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3815-15.2
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http://dx.doi.org/10.1523/JNEUROSCI.3815-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756160PMC
February 2016

MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65.

Cell Biosci 2016 12;6:10. Epub 2016 Feb 12.

Institute of Biomedicine, Jinan University, National Engineering Research Center of Genetic Medicine, Key Lab for Bioengineering Medicine of Guangdong Province, Guangzhou, Guangdong People's Republic of China.

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http://dx.doi.org/10.1186/s13578-016-0073-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751671PMC
February 2016

Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways.

Hum Mol Genet 2016 Apr 10;25(7):1294-306. Epub 2016 Jan 10.

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, Biomolecular Science and Engineering Program,

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http://dx.doi.org/10.1093/hmg/ddw010DOI Listing
April 2016

A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro.

Mol Cell Neurosci 2016 Mar 20;71:80-91. Epub 2015 Dec 20.

Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China; Guangzhou Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2015.12.011DOI Listing
March 2016

A specific RAGE-binding peptide biopanning from phage display random peptide library that ameliorates symptoms in amyloid β peptide-mediated neuronal disorder.

Appl Microbiol Biotechnol 2016 Jan 24;100(2):825-35. Epub 2015 Oct 24.

College of Pharmacy, Jinan University, 510632, Guangzhou, Guangdong, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-015-7001-7DOI Listing
January 2016

Direct Reprogramming of RESTing Astrocytes.

Cell Stem Cell 2015 Jul;17(1):1-3

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.06.011DOI Listing
July 2015

Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye.

Exp Eye Res 2015 Jul 16;136:93-9. Epub 2015 May 16.

Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical University, Chashan University Park, Wenzhou, 325035, China; The Eye Hospital of Wenzhou Medical University, #270 Xueyuan West Road, Wenzhou, 325027, China. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2015.05.006DOI Listing
July 2015

Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals.

Toxicology 2015 Aug 14;334:22-32. Epub 2015 May 14.

Institute of Biomedicine, and National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2015.05.003DOI Listing
August 2015

Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives.

Exp Mol Med 2015 Mar 13;47:e151. Epub 2015 Mar 13.

1] Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA [2] Biomedical Sciences Graduate Program, University of California, San Francisco, CA, USA [3] Department of Neurology, University of California, San Francisco, CA, USA [4] Department of Pathology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/emm.2014.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351411PMC
March 2015

Recombinant Nogo-66 via soluble expression with SUMO fusion in Escherichia coli inhibits neurite outgrowth in vitro.

Appl Microbiol Biotechnol 2015 Jul 12;99(14):5997-6007. Epub 2015 Mar 12.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, 510632, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-015-6477-5DOI Listing
July 2015

Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells.

Biol Reprod 2015 Mar 21;92(3):77. Epub 2015 Jan 21.

The 2nd Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China Population Council & Rockefeller University, New York, New York

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http://www.biolreprod.org/content/early/2015/01/15/biolrepro
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http://www.biolreprod.org/cgi/doi/10.1095/biolreprod.114.118
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http://dx.doi.org/10.1095/biolreprod.114.118463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376082PMC
March 2015

Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study.

Drug Des Devel Ther 2014 12;8:2555-602. Epub 2014 Dec 12.

Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA ; Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, People's Republic of China.

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http://dx.doi.org/10.2147/DDDT.S73476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271727PMC
December 2015

Directed mouse embryonic stem cells into leydig-like cells rescue testosterone-deficient male rats in vivo.

Stem Cells Dev 2015 Feb 18;24(4):459-70. Epub 2014 Dec 18.

1 Department of Cell Biology, College of Life Science and Technology, Jinan University , Guangzhou, People's Republic of China .

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http://dx.doi.org/10.1089/scd.2014.0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313439PMC
February 2015

Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.

J Neurosci 2014 Oct;34(42):14069-78

Gladstone Institute of Neurological Disease, San Francisco, California 94158, Department of Neurology and Biomedical Science Program, University of California, San Francisco, California 94143, Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, and Department of Pathology, University of California, San Francisco, California 94143

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http://www.jneurosci.org/content/34/42/14069.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2281-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.2281-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198545PMC
October 2014

Basic fibroblast growth factor promotes stem Leydig cell development and inhibits LH-stimulated androgen production by regulating microRNA expression.

J Steroid Biochem Mol Biol 2014 Oct 20;144 Pt B:483-91. Epub 2014 Sep 20.

Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Institute of Biomedicine, Jinan University, Guangzhou 510632, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2014.09.016DOI Listing
October 2014

Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

Neurobiol Dis 2014 Dec 27;72 Pt A:3-12. Epub 2014 Aug 27.

Gladstone Institute of Neurological Disease, University of California, San Francisco 94158, USA; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94158, USA; Department of Pathology, University of California, San Francisco 94158, USA; Department of Medicine, University of California, San Francisco 94158, USA.

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http://dx.doi.org/10.1016/j.nbd.2014.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253862PMC
December 2014

Expression, purification, and biological activity of the recombinant pramlintide precursor.

Appl Microbiol Biotechnol 2014 Sep 15;98(18):7837-44. Epub 2014 Apr 15.

National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, 510632, China.

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http://link.springer.com/10.1007/s00253-014-5699-2
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http://dx.doi.org/10.1007/s00253-014-5699-2DOI Listing
September 2014

Synthesis of novel curcumin analogues for inhibition of 11β-hydroxysteroid dehydrogenase type 1 with anti-diabetic properties.

Eur J Med Chem 2014 Apr 6;77:223-30. Epub 2014 Mar 6.

Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.012DOI Listing
April 2014

Identification of a novel aFGF-binding peptide with anti-tumor effect on breast cancer from phage display library.

Biochem Biophys Res Commun 2014 Mar 12;445(4):795-801. Epub 2014 Feb 12.

College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.02.022DOI Listing
March 2014

1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells.

Food Chem 2014 Jul 14;154:330-6. Epub 2014 Jan 14.

Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1016/j.foodchem.2014.01.017DOI Listing
July 2014

HSP27 as a biomarker for predicting skin irritation in human skin and reconstructed organotypic skin model.

Toxicol Lett 2014 Apr 3;226(2):124-31. Epub 2014 Feb 3.

Institute of Biomedicine and National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2014.01.043DOI Listing
April 2014

SIS8, a putative mitogen-activated protein kinase kinase kinase, regulates sugar-resistant seedling development in Arabidopsis.

Plant J 2014 Feb 23;77(4):577-88. Epub 2014 Jan 23.

Department of Plant Biology, University of Minnesota, St Paul, MN, 55108, USA.

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http://dx.doi.org/10.1111/tpj.12404DOI Listing
February 2014

Identification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferation.

Oncotarget 2013 Oct;4(10):1819-28

School of Pharmaceutical Science, Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, PR China.

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http://dx.doi.org/10.18632/oncotarget.1312DOI Listing
October 2013

Toxic mechanisms of 3-monochloropropane-1,2-diol on progesterone production in R2C rat leydig cells.

J Agric Food Chem 2013 Oct 3;61(41):9955-60. Epub 2013 Oct 3.

Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology , Guangzhou, 510006, China.

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http://dx.doi.org/10.1021/jf400809rDOI Listing
October 2013

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients.

J Neurol Neurosurg Psychiatry 2014 Mar 21;85(3):266-73. Epub 2013 Aug 21.

Department of Neurology, Memory & Aging Center, University of California, , San Francisco, California, USA.

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http://dx.doi.org/10.1136/jnnp-2013-305858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946299PMC
March 2014

A short peptide derived from the gN helix domain of FGF8b suppresses the growth of human prostate cancer cells.

Cancer Lett 2013 Oct 14;339(2):226-36. Epub 2013 Jun 14.

Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1016/j.canlet.2013.06.001DOI Listing
October 2013

NGF induces adult stem Leydig cells to proliferate and differentiate during Leydig cell regeneration.

Biochem Biophys Res Commun 2013 Jun 4;436(2):300-5. Epub 2013 Jun 4.

Department of Cell Biology, College of Life Science and Technology, Jinan University, 510632 Guangzhou, PR China.

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http://dx.doi.org/10.1016/j.bbrc.2013.05.098DOI Listing
June 2013

Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.

PLoS One 2013 19;8(3):e59478. Epub 2013 Mar 19.

Gladstone Institute of Neurological Disease, San Francisco, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602301PMC
September 2013

A versatile mass spectrometry-based method to both identify kinase client-relationships and characterize signaling network topology.

J Proteome Res 2013 Feb 15;12(2):937-48. Epub 2013 Jan 15.

Department of Biochemistry and Interdisciplinary Plant Group, University of Missouri, Columbia, Missouri 65211, USA.

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http://dx.doi.org/10.1021/pr3009995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888875PMC
February 2013

Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Neuron 2012 Dec;76(5):871-85

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891195PMC
December 2012

Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology.

J Med Chem 2012 Nov 5;55(21):8997-9008. Epub 2012 Oct 5.

Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/jm3008618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904786PMC
November 2012

Construction and characterization of a recombinant human beta defensin 2 fusion protein targeting the epidermal growth factor receptor: in vitro study.

Appl Microbiol Biotechnol 2013 May 5;97(9):3913-23. Epub 2012 Aug 5.

Institute of Biomedicine, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1007/s00253-012-4257-zDOI Listing
May 2013

Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application.

Peptides 2012 Oct 16;37(2):207-15. Epub 2012 Jul 16.

Biopharmaceutical Research and Development Center, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.

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http://dx.doi.org/10.1016/j.peptides.2012.07.001DOI Listing
October 2012

KiC assay: a quantitative mass spectrometry-based approach for kinase client screening and activity analysis [corrected].

Methods Mol Biol 2012 ;893:359-70

Interdisciplinary Plant Group, Department of Biochemistry, University of Missouri-Columbia, Columbia, MO, USA.

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http://dx.doi.org/10.1007/978-1-61779-885-6_22DOI Listing
September 2012

Alzheimer mechanisms and therapeutic strategies.

Cell 2012 Mar;148(6):1204-22

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.cell.2012.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319071PMC
March 2012

A validated high-performance liquid chromatographic method with diode-array detection for the estimation of xyloketal B in rat plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Feb 13;885-886:24-9. Epub 2011 Dec 13.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, PR China.

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http://dx.doi.org/10.1016/j.jchromb.2011.12.005DOI Listing
February 2012

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

Authors:
Yadong Huang

Biochem Soc Trans 2011 Aug;39(4):924-32

Gladstone Institute of Neurological Disease, Department of Pathology, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1042/BST0390924DOI Listing
August 2011

Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli.

Appl Microbiol Biotechnol 2012 Jan 29;93(2):613-21. Epub 2011 Jun 29.

Institute of Life and Health Engineering, and National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, 510632, People's Republic of China.

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http://dx.doi.org/10.1007/s00253-011-3427-8DOI Listing
January 2012

Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage.

Toxicol Lett 2011 Aug 12;205(2):183-9. Epub 2011 Jun 12.

National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China.

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http://dx.doi.org/10.1016/j.toxlet.2011.06.003DOI Listing
August 2011