Publications by authors named "Ya-Jie Liu"

30 Publications

  • Page 1 of 1

Aluminium nanorings: configuration deformation and structural transformation.

Chem Commun (Camb) 2021 Feb;57(16):2085-2088

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

Present herein is the first example of aluminium nanoring assembly by fatty acids. And the auxiliary alcohol sites can be modified either by monohydric alcohols (AlOC-33 to AlOC-35) or diols (AlOC-36 to AlOC-38). The monohydric alcohol modified ten-membered aluminium (Al10) rings are coplanar, while the diol modified ones possess a saddle-shaped configuration. Interestingly, the diol modified Al10 ring (AlOC-36) can convert into a coplanar ring (AlOC-33-B). AlOC-33-B possesses a similar molecular structure but a different supramolecular structure with AlOC-33. The structural transformation is confirmed to be a thermodynamically spontaneous process through density-functional theory (DFT) calculations.
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http://dx.doi.org/10.1039/d0cc07513bDOI Listing
February 2021

Designable Al -Oxo Clusters with Hydrotalcite-like Structures: Snapshots of Boundary Hydrolysis and Optical Limiting.

Angew Chem Int Ed Engl 2021 Feb 18;60(9):4849-4854. Epub 2021 Jan 18.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, P. R. China.

The hydrolysis of earth-abundant Al has implications in mineral mimicry, geochemistry and environmental chemistry. Third-order nonlinear optical (NLO) materials are important in modern chemistry due to their extensive optical applications. The assembly of Al ions with π-conjugated carboxylate ligands is carried out and the hydrolysis and NLO properties of the resultant material are studied. A series of Al -oxo clusters with hydrotalcite-like cores and π-conjugated shells are isolated. X-ray diffraction revealed boundary hydrolysis occurs at the equatorially unsaturated coordination sites of Al ions. Charge distribution analysis and DFT calculations support the proposed boundary substitution. The Al -oxo clusters possess a significant reverse saturable absorption (RSA) response with a minimal normalized transmittance up to 29 %, indicating they are suitable candidates for optical limiting (OL) materials. This work elucidates the hydrolysis of Al and provides insight into layered materials that also have strong boundary activity at the edges or corners.
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http://dx.doi.org/10.1002/anie.202012919DOI Listing
February 2021

Are you using the third definition to diagnose sepsis in clinic?-A survey among Chinese intensivists.

Ann Palliat Med 2020 Sep 17;9(5):2926-2932. Epub 2020 Aug 17.

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.

Background: Since sepsis-3 definition is more accurate and sensitive than previous sepsis definition, implementation the newest diagnosis criteria could definitely bring more benefit to sepsis patients. This study was done to identify the level of current intensivists' knowledge regarding the third international consensus definitions for sepsis and septic shock and its implementation for the diagnosis of sepsis among Chinese adult intensive care units (ICUs).

Methods: A nationwide survey amongst critical care physicians was designed. The questionnaires measured the understanding and the frequency of diagnosis of sepsis and septic shock according to the third international consensus definitions for sepsis and septic shock. One thousand random physician members of Chinese Society of Critical Care Medicine were involved in the survey. A 5-point Likert scale (totally understand, partially understand, understand, hardly understand, do not understand) was used to elicit answers about the degree of understanding the sepsis-3 definition. The other 5-point Likert scale (always, often, sometimes, rarely, never) was used to elicit answers about the frequency of diagnosing sepsis according to the sepsis-3 definition.

Results: There were 59 (16.1%) intensivists who could completely understand the sepsis-3 definition. Less practiced intensivists could understand the sepsis-3 definition better than more practiced intensivists (P<0.001). Intensivists from university teaching hospitals understand the sepsis-3 definition better than the intensivists from the community hospitals (P<0.001). Intensivists from small-sized ICUs understand the sepsis-3 definition better than intensivists from big-sized ICUs (P<0.001). There were 60 (16.4%) intensivists who always diagnose sepsis according to the sepsis-3 definition since sepsis-3 published. Less practiced intensivists prefer using the sepsis-3 definition to diagnose sepsis compared with more practiced intensivists (P<0.001). Intensivists from university teaching hospitals prefer using the sepsis-3 definition to diagnose sepsis compared with the intensivists from the community hospitals (P<0.001). Intensivists from small-sized ICUs prefer adapting sepsis-3 definition to diagnosis sepsis compared with intensivists from big-sized ICUs (P<0.001).

Conclusions: In current China, the sepsis-3 definition is well understood and accepted by intensivists.
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http://dx.doi.org/10.21037/apm-20-412DOI Listing
September 2020

Synthesis of Ag-Doped Polyoxotitanium Nanoclusters for Efficient Electrocatalytic CO Reduction.

Inorg Chem 2020 Aug 28;59(16):11442-11448. Epub 2020 Jul 28.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People's Republic of China.

Ag-Ti nanocomposite materials have drawn increasing research attention because of their superior catalytic properties. However, the preparation of a crystalline Ag-Ti material is an important challenge in synthetic chemistry. Herein, we report a family of atomically precise Ag-doped polyoxotitanium nanoclusters (PTCs) (-) with a size of 19.56 × 19.02 Å. Each Ag-PTC is made up of a tiny Ag kernel and a double-decker Ti nanowheel as well as an organic protective shell. Hence, they can be regarded as [email protected]@(L)(OMe) unique triple core-shell structures. Notably, the peripheral organic shell can be modified with different benzoate derivatives. With precise atomic information, these compounds can be used as ideal molecular models of Ag-Ti nanocomposite materials for studying the growth or reaction mechanism via theoretical calculations. Meanwhile, a -modified electrode presents efficient electrocatalytic CO reduction activity with a Faradaic efficiency (FE) of 29.4%. This work demonstrates that Ag-doped crystalline PTC materials are promising candidates for application to the electrocatalytic CO reduction reaction (CORR).
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http://dx.doi.org/10.1021/acs.inorgchem.0c01245DOI Listing
August 2020

The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats.

Sleep Breath 2021 Mar 19;25(1):325-330. Epub 2020 Jun 19.

Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Purpose: To study neurochemical reactions to chronic intermittent hypoxia (CIH) in the hypoglossal nucleus (HN) of rats.

Methods: Adult male Sprague-Dawley rats (n = 12) were randomly divided into two groups (the CIH and the control group). The CIH rats were housed in a hypoxic chamber with the fraction of oxygen volume alternating between 21% and 5% by providing air for 60 s and then providing nitrogen for 60 s from 8:30 am to 16:30 pm each day for 35 days. The control group was housed in a cabin with normal oxygen levels. We studied the expression of c-fos protein, 5-hydroxytryptamine (5-HT) positive terminals, and its 2A receptors in hypoglossal nuclei by immunohistochemistry.

Results: The expression of c-fos, 5-HT positive terminals, and accordingly 5-HT 2A receptors in the CIH group were significantly higher than that in the controls (p < 0.05). The ventral side of the HN showed a clearly higher expression of 5-HT and its 2A receptors than the dorsal side (p < 0.05).

Conclusion: There were 2 responses of the HN to CIH. First, CIH induced a higher expression of 5-HT positive terminals and its 2A receptors, and second, this reaction was much more evident in ventral side than in the dorsal side. We postulate that these responses may serve to be a protective and compensatory mechanism for CIH.
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http://dx.doi.org/10.1007/s11325-020-02125-xDOI Listing
March 2021

Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients.

Laryngoscope 2020 03 12;130(3):E83-E88. Epub 2019 Jun 12.

Department of Radiation Oncology, Sichuan Cancer Hospital and Research Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, PR China.

Objectives: There is currently no consensus on the prognostic significance of the histological subtype of nasopharyngeal carcinoma (NPC). The aim of the current study was to evaluate the impact of histological subtype on survival in NPC patients based on the Surveillance, Epidemiology, and End Results (SEER) Program.

Methods: Patients with NPC were identified within the SEER database (2004-2015). The effects of histological subtype on cause-specific survival (CSS) in NPC patients were evaluated using univariate and multivariate Cox regression analyses. Subgroup analysis according to histological subtype in NPC patients was carried out by 1:1 propensity score matching (PSM).

Results: A total of 4085 NPC patients were selected from the SEER database, including 1929 with keratinizing squamous cell carcinoma (KSCC), 2203 with nonkeratinizing carcinoma (NKC), and 53 with basaloid squamous cell carcinoma (BSCC). The 3-year and 5-year CSS rates were 61.76% and 55.07% for KSCC patients, 79.57% and 72.09% for NKC patients, and 77.55% and 74.03% for BSCC patients, respectively. Multivariate analysis identified sex, age, marital status, race, T stage, N stage, M stage, radiotherapy, chemotherapy, and histological subtype as significant prognostic factors for CSS in NPC patients. KSCC was found to be associated with worse CSS than NKC on Kaplan-Meier analysis and subgroup analysis after 1:1 PSM.

Conclusions: Histological subtype determines the long-term survival outcomes of patients with NPC. Moreover, the NKC subtype has the best prognosis, while the KSCC subtype has the worst prognosis.

Level Of Evidence: NA Laryngoscope, 130:E83-E88, 2020.
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http://dx.doi.org/10.1002/lary.28099DOI Listing
March 2020

A simplified T classification based on the 8th edition of the UICC/AJCC staging system for nasopharyngeal carcinoma.

Cancer Manag Res 2019 11;11:3163-3169. Epub 2019 Apr 11.

Department of Oncology, Nanhai Hospital Affiliated to Southern Medical University, Foshan, Guangdong 528200, People's Republic of China.

This study aimed to establish a simplified T classification based on the 8th edition of the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system for nasopharyngeal carcinoma (NPC). In total, 325 patients with NPC were included in this study. All patients underwent magnetic resonance imaging, and the staging criteria were recorded. These patients were subjected to staging with the 8th edition of the UICC/AJCC staging system for NPC. Involvement of the oropharynx, nasal cavity, adjacent soft tissue (medial pterygoid, lateral pterygoid, and prevertebral muscles), cervical vertebra, orbit, and hypopharynx were always accompanied by other equivalently or more advanced T-stage classifications. All cases with involvement of the paranasal sinuses showed skull base erosion. The majority of cases with involvement of the pterygoid structure showed skull base erosion. According to the simplification principle, the following new T classification based on the 8th edition of the UICC/AJCC staging system was established: T1, tumor confined to nasopharynx, or beyond the nasopharynx without parapharyngeal involvement; T2, tumor with extension to the parapharyngeal space; T3, tumor with infiltration to bony structures at the skull base; T4, tumor with intracranial extension, involvement of the cranial nerves or parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle. Validation with a large series of patients is needed.
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http://dx.doi.org/10.2147/CMAR.S185860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489657PMC
April 2019

Recent advances in isopolyoxotungstates and their derivatives.

Acta Crystallogr C Struct Chem 2018 Nov 18;74(Pt 11):1202-1221. Epub 2018 Oct 18.

Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan Province, People's Republic of China.

During the past decade, isopolyoxotungstates (iso-POTs) and their derivatives have been greatly developed due to their unique structures and potential applications in luminescence, magnetism, catalysis etc. This brief review is principally focused on the main research progress on iso-POTs, iso-POT-based transition-metal derivatives, iso-POT-based rare-earth derivatives, iso-POT-based organometallic derivatives and iso-POT-based heterometallic derivatives, and gives a summary of some representative examples of their syntheses, structures and related properties. In addition, an outlook on the future of this area is presented in the final section. We believe that this systematic commentary on iso-POTs and their derivatives will not only disclose a rich set of iso-POT structures, but also reveal a more promising direction for the further functionalization of iso-POTs.
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http://dx.doi.org/10.1107/S2053229618012524DOI Listing
November 2018

Unprecedented Selenium and Lanthanide Simultaneously Bridging Selenotungstate Aggregates Stabilized by Four Tetra-vacant Dawson-like {Se W } Units.

Chem Asian J 2018 Oct 29;13(19):2897-2907. Epub 2018 Aug 29.

MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing, 100081, China.

In the presence of the larger [H N(CH ) ] and K counter cations as structure-stabilizing agents, a class of unprecedented selenium and lanthanide (Ln) simultaneously bridging tetra-vacant Dawson-like selenotungstate aggregates [H N(CH ) ] Na K H {[Ln W Se O (H O) ](Se W O ) } ⋅60 H O [Ln=Tb (1), Dy (2), Ho (3), Er (4), Tm (5), Yb (6)] have been obtained by the one-pot assembly reaction of Na WO ⋅2 H O, Ln(NO ) ⋅6 H O, and Na SeO under moderately acidic aqueous conditions and the complexes were structurally characterized by elemental analyses, IR spectra, single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. It should be noted that the appropriate molar ratio of Se/W is extremely important in the formation of 1-6 and can effectively ameliorate the yield of 1-6. Moreover, dimethylamine hydrochloride is also indispensable and plays a considerably important role in improving the solubility of Ln ions and stabilizing the structures of 1-6. The main polyoxoanion skeletons of 1-6 are constructed from two sandwich-type tetra-vacant Dawson-like {[Ln W Se O (H O) ](Se W O ) } half-units linked through two W-O-Ln bridges. The sandwich-type half-unit comprises two tetra-vacant Dawson-like [Se W O ] fragments encapsulating a unique dodecanuclear Se-Ln-W [Ln W Se O (H O) ] oxo cluster. Their solid-state visible and NIR fluorescent properties and lifetime decay behaviors were measured and their solid-state luminescent spectra mainly demonstrate the characteristic emission bands of Ln ions. Moreover, the dominant wavelengths, the color purity, and correlated color temperatures of 1-5 have been also calculated. In addition, the luminous flux values of 1-5 are 2031, 6992, 3071, 921, and 477 lumen, respectively.
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http://dx.doi.org/10.1002/asia.201801010DOI Listing
October 2018

Nucleocapsid protein from porcine epidemic diarrhea virus isolates can antagonize interferon-λ production by blocking the nuclear factor-κB nuclear translocation.

J Zhejiang Univ Sci B 2018 Jul;19(7):570-580

Zhejiang Province Key Lab of Preventive Veterinary Medicine, Institute of Preventive Veterainary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Porcine epidemic diarrhea virus (PEDV) is a highly infectious pathogen that can cause severe diseases in pigs and result in enormous economic losses in the worldwide swine industry. Previous studies revealed that PEDV exhibits an obvious capacity for modulating interferon (IFN) signaling or expression. The newly discovered type III IFN, which plays a crucial role in antiviral immunity, has strong antiviral activity against PEDV proliferation in IPEC-J2 cells. In this study, we aimed to investigate the effect of PEDV nucleocapsid (N) protein on type III IFN-λ. We found that the N proteins of ten PEDV strains isolated between 2013 and 2017 from different local farms shared high nucleotide identities, while the N protein of the CV777 vaccine strain formed a monophyletic branch in the phylogenetic tree. The N protein of the epidemic strain could antagonize type III IFN, but not type I or type II IFN expression induced by polyinosinic-polycytidylic acid (poly(I:C)) in IPEC-J2 cells. Subsequently, we demonstrated that the inhibition of poly(I:C)-induced IFN-λ3 production by PEDV N protein was dependent on the blocking of nuclear factor-κB (NF-κB) nuclear translocation. These findings might help increase understanding of the pathogenesis of PEDV and its mechanisms for evading the host immune response.
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http://dx.doi.org/10.1631/jzus.B1700283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052364PMC
July 2018

Topology Engineering of Proteins Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stability.

ACS Cent Sci 2017 May 10;3(5):473-481. Epub 2017 May 10.

Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.

Recombinant proteins are traditionally limited to linear configuration. Herein, we report protein topology engineering using highly efficient, mechanically interlocking SpyX modules named AXB and BXA. SpyX modules are protein domains composed of p53dim (X), SpyTag (A), and SpyCatcher (B). The p53dim guides the intertwining of the two nascent protein chains followed by autocatalytic isopeptide bond formation between SpyTag and SpyCatcher to fulfill the interlocking, leading to a variety of backbone topologies. Direct expression of AXB or BXA produces protein catenanes with distinct ring sizes. Recombinant proteins containing SpyX modules are obtained either as mechanically interlocked obligate dimers if the protein of interest is fused to the N- or C-terminus of SpyX modules, or as star proteins if the protein is fused to both N- and C-termini. As examples, cellular syntheses of dimers of (GB1) (where GB1 stands for immunoglobulin-binding domain B1 of streptococcal protein G) and of four-arm elastin-like star proteins were demonstrated. Comparison of the catenation efficiencies in different constructs reveals that BXA is generally much more effective than AXB, which is rationalized by the arrangement of three domains in space. Mechanical interlocking induces considerable stability enhancement. Both AXB and BXA have a melting point ∼20 °C higher than the linear controls and the BXA catenane has a melting point ~2 °C higher than the cyclic control BX'A. Notably, four-arm elastin-like star proteins demonstrate remarkable tolerance against trypsin digestion. The SpyX modules provide a convenient and versatile approach to construct unconventional protein topologies via the "assembly-reaction" synergy, which opens a new horizon in protein science for stability enhancement and function reinforcement via topology engineering.
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http://dx.doi.org/10.1021/acscentsci.7b00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445526PMC
May 2017

Triiodothyronine promotes the proliferation of epicardial progenitor cells through the MAPK/ERK pathway.

Biochem Biophys Res Commun 2017 04 14;486(2):372-377. Epub 2017 Mar 14.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

Thyroid hormone has important functions in the development and physiological function of the heart. The aim of this study was to determine whether 3,5,3'-Triiodothyronine (T3) can promote the proliferation of epicardial progenitor cells (EPCs) and to investigate the potential underlying mechanism. Our results showed that T3 significantly promoted the proliferation of EPCs in a concentration- and time-dependent manner. The thyroid hormone nuclear receptor inhibitor bisphenol A (100 μmol/L) did not affect T3's ability to induce proliferation. Further studies showed that the mRNA expression levels of mitogen-activated protein kinase 1 (MAPK1), MAPK3, and Ki67 in EPCs in the T3 group (10 nmol/L) increased 2.9-, 3-, and 4.1-fold, respectively, compared with those in the control group (P < 0.05). In addition, the mRNA expression of the cell cycle protein cyclin D1 in the T3 group increased approximately 2-fold compared with the control group (P < 0.05), and there were more EPCs in the S phase of the cell cycle (20.6% vs. 12.0%, P < 0.05). The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway inhibitor U0126 (10 μmol/L) significantly inhibited the ability of T3 to promote the proliferation of EPCs and to alter cell cycle progression. This study suggested that T3 significantly promotes the proliferation of EPCs, and this effect may be achieved through activation of the MAPK/ERK signaling pathway.
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http://dx.doi.org/10.1016/j.bbrc.2017.03.048DOI Listing
April 2017

A randomized, controlled comparison of different intensive lipid-lowering therapies in Chinese patients with non-ST-elevation acute coronary syndrome (NSTE-ACS): Ezetimibe and rosuvastatin versus high-dose rosuvastatin.

Int J Cardiol 2017 May 23;235:49-55. Epub 2017 Feb 23.

The Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Statin combined with ezetimibe demonstrates significant benefit in lowering low density lipid cholesterol (LDL-C) and cardiovascular events abroad, but whether intermediate intensity statins combined with ezetimibe is superior to high-intensity statin monotherapy in Chinese people is unknown.

Methods: A total of 125 patients were randomly assigned to a intermediate intensity rosuvastatin group (rosuvastatin 10mg/d, n=42), high-dose rosuvastatin group (rosuvastatin 20mg/d, n=41) or combination therapy group (ezetimibe 10mg/d and rosuvastatin 10mg/d, n=42) with a 12-week follow-up. The primary end point was the proportion of patients who achieved the 2011 ESC/EAS LDL-C goal <70mg/dL (1.8mmol/L) at week 12. Secondary end points included changes from baseline in lipids, the occurrence of all cardiovascular events, high-sensitivity C-reactive protein and safety markers.

Results: The combination therapy group in the primary end point was significantly higher than rosuvastatin (20mg) and rosuvastatin (10mg) at week 12 (81.0% vs 68.3% vs 33.3%, P<0.001). And the similar change was observed in reducing LDL-C levels at week 12 (67.28% vs 52.80% vs 43.89%, P<0.001). The incidence of drug-related adverse events was much higher in the rosuvastatin 20mg group than the rosuvastatin 10mg group and the combination therapy group (17.0% vs 2.4% vs 4.8%, P<0.05).

Conclusions: The combination of rosuvastatin 10mg/ezetimibe 10mg was an effectively alternative therapy superior to rosuvastatin 20mg or 10mg with a greater effect on lowering LDL-C and a lower incidence of drug-related adverse events in Chinese patients.
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http://dx.doi.org/10.1016/j.ijcard.2017.02.099DOI Listing
May 2017

Structural Transformation from Dimerization to Tetramerization of Serine-Decorated Rare-Earth-Incorporated Arsenotungstates Induced by the Usage of Rare-Earth Salts.

Chemistry 2017 Feb 27;23(11):2673-2689. Epub 2017 Jan 27.

MOE Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing, 100081, P.R. China.

Three types of serine-decorated rare- earth-containing arsenotungstate [H N(CH ) ] NaH[RE W O (H O) (Ser) (B-α-AsW O ) ]⋅30 H O (RE =Eu , Gd , Tb , Dy , Ho , Er , Tm , Yb , and Y ; 1), [H N(CH ) ] Na RE H [RE W O (H O) (OH) (Ser) (B-α-AsW O ) ]⋅n H O (RE =Tb , x=1, y=2, n=36; RE =Dy , Ho , Er , Yb , Y , x=0, y=0, n=38; RE = Tm , x=1, y=0, n=38; Ser=serine; 2), and [H N(CH ) ] Na RE H [RE W O (H O) (OH) (Ser) (B-α-AsW O ) ]⋅Cl ⋅n H O (RE =Ce , Pr , x=1, y=0, n=65; RE =Nd , Sm , x=0, y=0, n=65; RE =Eu , Gd , x=1, y=2, n=45; 3) were synthesized with the participation of the organic solubilizers dimethylamine hydrochloride and l-serine and were structurally characterized. The use of different amounts of rare-earth salts results in the structural transformation from dimerization to tetramerization of types 1-3. Type 1 is a dimeric sandwich-type assembly of a dual-Ser-participating [RE W O (H O) (Ser) ] entity sandwiched by two [B-α-AsW O ] moieties, whereas types 2 and 3 have a tetrameric square structure formed by four [B-α-AsW O ] moieties that anchor a dual/tetra- Ser-participating [RE W O (H O) (OH) (Ser) ] or [RE W O (H O) (OH) (Ser) ] core. The solid-state luminescence properties and lifetime-decay behaviors of these compounds were investigated. The chromaticity coordinates, dominant wavelengths, color purities, and correlated color temperatures were also calculated.
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http://dx.doi.org/10.1002/chem.201605070DOI Listing
February 2017

[Expression and Clinical Significance of N-cadherin in Bone Marrow Leukemic Cells Derived from Patients with Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016 Oct;24(5):1312-1318

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Objective: To investigate the expression of N-cadherin in bone marrow leukemic cells derived from acute leukemia patients and its clinical significances.

Methods: A total of 113 patients with acute leukemia were enrolled in this study. Flow cytometry was employed to detect the expression of N-Cadherin in bone marrow leukemic cells from acute leukemia patients and the relationships between the N-cadherin expression and the clinical characteristics of patients with acute leukemia were analyzed.

Results: The expression of N-Cadherin in bone marrow leukemic cells deriveted from patients with acute leukemia was variable with 0%-99.7%. For adult AML patients, the positive rate of CD34 in N-cadherin group was significantly higher than that in N-cadherin group(67.39% vs 33.33%)(P=0.013), while the differences of total CR rate and rate of CR after 1 cycle of induction treatment were not significant between these 2 groups(P>0.05). As to ALL patients, N-cadherin group had significant lower WBC count (21.31±7.07 vs 51.10±23.69)(P=0.008) and lower percentage of peripheral blood blast (43.22±5.75% vs 66.45±5.65%)(P=0.015). The CR rate after 1 cycle of induction treatment and rate of overall CR were lower and the relapse rate was higher in N-cadherin ALL group than those in N-cadherin ALL group, but the differences were not significant (P>0.05). For childhood ALL, the positive rate of CD33 in N-cadherin group was significantly higher than that in N-cadherin group(47.62% vs 0%)(P=0.012). The relapse rate was higher in N-cadherin group than that in N-cadherin group (30.00% vs 0%)(P=0.115). The median survival time, 3-year overall OS rate and 3-year relapse-free survival rate in N-cadherin groups of adult AML, non-M3 AML, ALL and chidhood ALL paients were superior to N-cadherin groups, but the differences were not significant.

Conclusion: The expression of N-cadherin in bone marrow leukemic cells relates to some clinical features of patients with acute leukemia and to some extent has inferior effect on survival of patients with acute leukemia.
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http://dx.doi.org/10.7534/j.issn.1009-2137.2016.05.005DOI Listing
October 2016

Efficacy of Clopidogrel and Clinical Outcome When Clopidogrel Is Coadministered With Atorvastatin and Lansoprazole: A Prospective, Randomized, Controlled Trial.

Medicine (Baltimore) 2015 Dec;94(50):e2262

From the Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China (J-rZ, D-qW, JD, G-sQ, J-lD, S-bD, Y-jL, QS); Department of Cardiology, The DongNan Hospital, Chongqing, China (J-rZ); and Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China (J-xC).

This prospective, randomized, nonblind, controlled trial evaluated the effects of clopidogrel on platelet function upon coadministration with atorvastatin and lansoprazole. One hundred four adult patients with non-ST-segment elevated acute coronary syndrome (NSTE-ACS) who underwent percutaneous coronary intervention (PCI) with drug-eluting stent implantation were included. All patients were treated with standard dual antiplatelet therapy (DAPT) plus rosuvastatin 10  mg daily after the operation. On the sixth day after PCI, patients were randomly divided into 4 groups, Group A: DAPT + atorvastatin 20  mg daily (a change from rosuvastatin to atorvastatin) + lansoprazole 30  mg daily, Group B: DAPT + atorvastatin 20  mg daily (a change from rosuvastatin to atorvastatin), Group C: DAPT + lansoprazole 30  mg daily (continuing to take rosuvastatin), Group D is the control group. Additional drugs were used according to the situation of patients. Platelet function and concentrations of platelet activation markers (granular membrane protein 140 (P-selectin), thromboxane B2 (TXB2), and human soluble cluster of differentiation 40 ligand (sCD40L)) were assessed before randomization and at 15- and 30-day follow-up visits. All patients were maintained on treatment for 6 months and observed for bleeding and ischemic events. A total of 104 patients were enrolled, 27 patients in group A, 26 patients in Group B/C, 25 patients in Group D separately, and all the patients were analyzed. There were no differences in platelet function and the levels of platelet activation markers (P-selectin, TXB2, and sCD40L) among or within the 4 groups at the 3 time points of interest (P > 0.05). In the subsequent 6 months, no significant bleeding events occurred, and 12 patients experienced ischemic events, these results were also not significantly different among the groups (P > 0.05). In patients diagnosed with NSTE-ACS who have had drug-eluting stent implantation, simultaneously administering clopidogrel, atorvastatin, and lansoprazole did not decrease the antiplatelet efficacy of clopidogrel or increase adverse event frequency over 6 months.
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http://dx.doi.org/10.1097/MD.0000000000002262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058921PMC
December 2015

The effects of a low-salt diet on the efficacy of different antihypertensive drug regimens.

J Clin Pharmacol 2015 Dec 21;55(12):1362-8. Epub 2015 Jul 21.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The objective of this study was to compare the antihypertensive effects of 3 types of antihypertensive drug regimens between different salt intake levels. The 180 patients with mild to moderate primary hypertension participating in this randomized, controlled clinical trial were randomly allocated to a low-salt diet (LSD) group or a non-low-salt diet (NLSD) group. Each group included 3 subgroups: a losartan 100 mg subgroup, a losartan 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg subgroup, and an irbesartan 150 mg/HCTZ 12.5 mg subgroup. The LSD group received a diet in which the sodium content was strictly controlled (2.3 g/day). After 2 months, the office blood pressure (BP), the 24-hour mean BP, and the morning BP were significantly reduced (P ≤ .01) in each group. No significant differences were observed between the 3 LSD subgroups (P > .05). In the NLSD group, the losartan 50 mg/HCTZ 12.5 mg subgroup, and the irbesartan 150 mg/HCTZ 12.5 mg subgroup exhibited identical antihypertensive efficacy (P > .05), and these groups were significantly different from the losartan 100 mg subgroup(P ≤ .05). The BP of the patients who received the LSD was further decreased compared with those who received the NLSD (P ≤ .05). Therefore, we concluded that this LSD exerts synergistic BP-reducing effects.
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http://dx.doi.org/10.1002/jcph.559DOI Listing
December 2015

High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis.

BMJ Open 2015 May 15;5(5):e006886. Epub 2015 May 15.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To evaluate the efficacy and safety of high-intensity statin therapy in patients with chronic kidney disease (CKD).

Design: A systematic review and meta-analysis.

Data Sources: Randomised controlled trials (RCTs) comparing high-intensity statin therapy (atorvastatin 80 mg or rosuvastatin 20/40 mg) with moderate/mild statin treatment or placebo were derived from the databases (PubMed, Embase, Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, and ISI Web of Knowledge).

Outcome Measure: Primary end points: clinical events (all-cause mortality, stroke, myocardial infarction and heart failure); secondary end points: serum lipid, renal function changes and adverse events.

Results: A total of six RCTs with 10,993 adult patients with CKD were included. A significant decrease in stroke was observed in the high-intensity statin therapy group (RR 0.69, 95% CI 0.56 to 0.85). However, the roles of high-intensity statin in decreasing all-cause mortality (RR 0.85, 95% CI 0.67 to 1.09), myocardial infarction (RR 0.69, 95% CI 0.40 to 1.18) and heart failure (RR 0.73, 95% CI 0.48 to 1.13) remain unclear with low evidence. High-intensity statin also had obvious effects on lowering the LDL-C level but no clear effects on renal protection. Although pooled results showed no significant difference between the intervention and control groups in adverse event occurrences, it was still insufficient to put off the doubts that high-intensity statin might increase adverse events because of limited data sources and low quality evidences.

Conclusions: High-intensity statin therapy could effectively reduce the risk of stroke in patients with CKD. However, its effects on all-cause mortality, myocardial infarction, heart failure and renal protection remain unclear. Moreover, it is hard to draw conclusions on the safety assessment of intensive statin treatment in this particular population. More studies are needed to credibly evaluate the effects of high-intensity statin therapy in patients with CKD.
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http://dx.doi.org/10.1136/bmjopen-2014-006886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442158PMC
May 2015

The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis.

Clin Chim Acta 2015 Jun 8;446:248-52. Epub 2015 May 8.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in the cardiovascular system. We explored the relationship between the HDL-S1P concentrations and coronary in-stent restenosis (ISR).

Methods: Fifty consecutive patients with ISR and 50 normal control subjects were included. The serum S1P, HDL-S1P and clinical data were collected to explore the relationships between these parameters and ISR.

Results: The patients with ISR had significantly lower concentrations of serum S1P (96.10 ± 26.33 vs. 113.40 ± 32.72; P = 0.004) and HDL-S1P (32.81 ± 10.02 vs. 42.72 ± 11.75; P < 0.001). All included patients were divided into four quartiles based on their concentrations of HDL-S1P: Quartile 1 (18.63-28.51 ng/ml), Quartile 2 (28.62-37.28 ng/ml), Quartile 3 (37.35-45.27 ng/ml), and Quartile 4 (45.59-79.36 ng/ml). The rates of ISR were 84%, 48%, 40% and 28%, respectively. The patients in Quartile 1 exhibited significantly higher rates of ISR compared with the other groups (P = 0.001). A multivariate stepwise logistic regression analysis indicated that HDL-S1P (OR = 0.846, 95% CI = 0.767-0.932, P = 0.001) was an independent predictor of ISR. An ROC analysis indicated that HDL-S1P = 30.37 ng/ml and had a 90% sensitivity and a 52% specificity in predicting ISR.

Conclusions: HDL-S1P is an independent predictor of ISR, and patients with higher concentrations of HDL-S1P have a low risk of ISR.
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http://dx.doi.org/10.1016/j.cca.2015.04.038DOI Listing
June 2015

Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups.

Bioorg Med Chem Lett 2015 Apr 3;25(8):1778-1781. Epub 2015 Mar 3.

Department of Environmental Engineering, Guangdong Industry Technical College, Guangzhou 510300, People's Republic of China. Electronic address:

Four types of ligands (Q1-Q4) and their complexes (1-36) with transition metal ions have been synthesized, in which two new complexes (15 and 20) have been prepared and tested. In vitro antimicrobial activities of the ligands and their complexes were investigated against a representative panel of strains including two Gram positive bacteria (Sarcina ureae, Staphylococcus aureus), two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungi (Aspergillus niger, Saccharomyces cerevisiae, Fusarium oxysporum f. sp. cubense). The relationship between the structure and the antibacterial activities was discussed. Our study results indicated that some compounds have preferred antibacterial activities that may have potential pharmaceutical applications.
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http://dx.doi.org/10.1016/j.bmcl.2015.02.056DOI Listing
April 2015

Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in coronary artery disease: A systematic review and meta-analysis.

Int J Cardiol 2015 Apr 4;184:703-709. Epub 2015 Mar 4.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: The study performed a meta-analysis of the diagnostic performance of fractional flow reserve (FFR) derived from coronary computed tomography angiography (FFRCT) to assess the functional significance of coronary stenosis using FFR as the reference standard.

Methods: We searched the electronic databases of PubMed, EMBASE, The Chorance Library, Medion and Web of Science for relevant articles published until August 2014. Pooled estimates of sensitivity, specificity, positive (LR+) and negative likelihood ratios (LR-) with the corresponding 95% confidence intervals (CIs) and the summary receiver operating characteristic curve (SROC) were determined.

Results: Five studies, 706 patients and 1165 vessels or lesions were included in the meta-analysis. The pooled sensitivity and specificity for FFRCT at the per-patient level were 90% (95% CI, 85%-93%) and 72% (95% CI, 67%-76%), respectively. The corresponding pooled LR+ and LR- were 3.70 (95% CI, 2.11-6.49) and 0.15 (95% CI, 0.11-0.22), respectively. The pooled sensitivity and specificity for FFRCT on the per-vessel or per-lesion basis were 83% (95% CI, 79%-87%) and 78% (95% CI, 75%-81%), respectively. Corresponding pooled LR+ and LR- were 3.75 (95% CI, 2.09-6.74) and 0.22 (95% CI, 0.18-0.29), respectively. The area under the SROC (AUC) was 0.94 at the per-patient level and 0. 91 at the per-vessel or per-lesion level.

Conclusions: The existing evidence suggests that noninvasive FFRCT has high diagnostic performance compared with invasively measured FFR for the detection of ischemia-causing stenosis in stable patients with suspected or known coronary artery disease (CAD).
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http://dx.doi.org/10.1016/j.ijcard.2015.03.025DOI Listing
April 2015

Adjunctive manual thrombus aspiration during ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials.

PLoS One 2014 18;9(11):e113481. Epub 2014 Nov 18.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: The aim of this study was to synthesize evidence by examining the effects of manual thrombus aspiration on clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI).

Methods And Results: A total of 26 randomized controlled trials (RCTs), enrolling 11,780 patients, with 5,869 patients randomized to manual thrombus aspiration and 5,911 patients randomized to conventional percutaneous coronary intervention (PCI), were included in the meta-analysis. Separate clinical outcome analyses were based on different follow-up periods. There were no statistically reductions in the incidences of mortality (risk ratio [RR], 0.86 [95% confidence interval [CI]: 0.73 to 1.02]), reinfarction (RR, 0.62 [CI, 0.31 to 1.32]) or target vessel revascularization (RR, 0.89 [CI, 0.75 to 1.05]) in the manual thrombus aspiration arm at 12 to 24 months of follow-up. The composite major adverse cardiac events (MACEs) outcomes were significantly lower in the manual thrombus aspiration arm over the long-term follow-up (RR, 0.76 [CI, 0.63 to 0.91]). A lower incidence of reinfarction was observed in the hospital to 30 days (RR, 0.59 [CI, 0.37 to 0.92]).

Conclusion: The present meta-analysis suggested that there was no evidence that using manual thrombus aspiration in patients with STEMI could provide distinct benefits in long-term clinical outcomes.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236171PMC
January 2016

Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats.

Biochem Biophys Res Commun 2013 Sep 9;438(4):628-34. Epub 2013 Aug 9.

Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.

Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear factor (NF)-κB signaling, and to explore its association with hippocampal interleukin (IL)-1β levels and anesthetic-related cognitive changes in aged rats. After a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increases in IκB kinase and IκB phosphorylation, as well as a reduction in the NF-κB inhibitory protein (IκBα), were observed in the hippocampi of isoflurane-exposed rats compared with control rats. These events were accompanied by an increase in NF-κB p65 nuclear translocation at 6h after isoflurane exposure and hippocampal IL-1β elevation from 1 to 6h after isoflurane exposure. Nevertheless, no significant neuroglia activation was observed. Pharmacological inhibition of NF-κB activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1β increase and NF-κB signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal IL-1β, partially via activation of the canonical NF-κB pathway, in aged rats.
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http://dx.doi.org/10.1016/j.bbrc.2013.08.003DOI Listing
September 2013

[Research and determination of occupational exposure limits of nitroguanidine in air of working places].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2010 May;28(5):380-2

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May 2010

The catalytic efficiency of trehalose-6-phosphate synthase is effected by the N-loop at low temperatures.

Arch Microbiol 2010 Nov 14;192(11):937-43. Epub 2010 Sep 14.

Key Laboratory of Arid and Grassland Agroecology of the Ministry of Education, School of Life Sciences, Lanzhou University, 730000, Lanzhou, People's Republic of China.

The enzyme OtsA (trehalose-6-phosphate synthase) is ubiquitous in both prokaryotic and eukaryotic organisms, where it plays a critical role in stress resistance and glucose metabolism. Here, we cloned the otsA gene from Arthrobacter sp. Cjts, and expressed and then purified the recombinant proteins. Enzyme activity analysis indicated that the high catalytic efficiency of OtsA from Arthrobacter sp. Cjts resulted from the high affinity of the enzyme for uridine 5'-diphosphoglucose (UDP-Glc) at low temperatures. We also confirmed that the N-loop sequence of OtsA has a large effect on its affinity for UDP-Glc. Sequence analysis indicated that the flexibility of the N-loop may be directly related to the catalytic efficiency of OtsA at low temperatures.
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http://dx.doi.org/10.1007/s00203-010-0625-1DOI Listing
November 2010

[Mutagenicity and teratogenicity of hexanitrohexaazaisowurtzitane].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007 Jan;25(1):41-2

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January 2007

[Morphological characteristics of internal carotid artery atherosclerotic lesions in digital subtracted angiography].

Nan Fang Yi Ke Da Xue Xue Bao 2006 Jun;26(6):767-9, 773

Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

Objective: To illustrate the morphological characteristics of atherosclerotic lesions of the internal carotid artery.

Methods: The morphological characteristics of cervicocerebral atherosclerotic lesions in digital subtracted angiography were retrospectively reviewed in 120 cases.

Results: Totally 217 atherosclerotic lesions were detected. Of all the lesions, moderately and severely stenosed lesions accounted for 62.21% and mild stenosed lesions for 37.79%; long lesions were found in 18.89% and short ones in 81.11%; 37.33% of the lesions were ulcerated while 62.67% were non-ulcerated; 13.36% were angulated lesions and 86.64% non-angulated; 50.23% were eccentric lesions and 49.77% were concentric; lesions with adjacent artery dilation were found in 9.22%, and lesions without with adjacent artery dilation in 90.78%.

Conclusion: The atherosclerotic lesions are characterized by moderate to severe stenosis and non-ulcerated, non-angulated, eccentric lesions without adjacent artery dilation.
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June 2006

[Clinical observation on effect of shenqi fanghou recipe in preventing and treating radiation injury in patients with head and neck tumor].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2005 Jul;25(7):623-5

The Second Hospital Affiliated to Medical College, Jinan University, Guangdong.

Objective: To observe the therapeutic effect of shenqi fanghou recipe (SFR) in preventing and treating radiation injury in patients with head and neck tumor.

Methods: One hundred and forty patients with head and neck tumor, including nasopharyngeal carcinoma, carcinoma of tonsil or tongue, were randomly divided into 2 groups, 70 patients in the observed group were given modified SFR as adjuvant to radiotherapy, while 70 patients in the control group were treated with radiotherapy alone. The radiation reactions during radiotherapy and the condition of late stage radiation injury radiotherapy in patients in the 2 groups were observed.

Results: The degree of oropharyngeal mucosa reaction, dryness in mouth and radiation dermatitis in cervical region in the observed group was milder than those in the control group, and the radiation injury induced late stage sequelae, such as the degree of mouth-opening was better and the cervical muscular sclerosis was better in the observed group than in the control group, showing significant difference (P < 0.01).

Conclusion: SFR has definite effect in preventing and treating radiation reaction and late stage radiation injury in patients with head and neck tumor.
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July 2005

In vitro culture and induced differentiation of adult rat neural stem cells from the corpus striatum.

Di Yi Jun Yi Da Xue Xue Bao 2004 Feb;24(2):192-4, 197

Department of Neurology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.

Objective: To investigate the in vitro multipotential differentiation of neural stem cells from adult rat corpus striatum.

Methods: The neural stem cells isolated from adult rat corpus striatum were cultured in serum-free medium to obtain cell suspension before monoclonal subculturing and differential induction. Immunocytochemical staining and reverse transcriptional PCR (RT-PCR) were performed to identify the properties of the differentiated cells.

Results: Numerous cell clusters were formed in the phase of monoclonal culture, and different types of cells were observed 3 d after induction with fetal bovine serum. The differentiated cells contained cells positive for nestin, neuron-specific enolase (NSE) positive cells, and glial fibrillary acidic protein (GFAP) positive cells. RT-PCR identified expressions of the transcripts for neural cell-associated genes including brain factor-1, gamma-aminobutyric acid alpha-receptor gamma-subunit, tyrosine hydroxylase and tryptophan hydroxylase.

Conclusion: The cells separated from adult rat corpus striatum possess the ability of self-proliferation and multipotential differentiation, and are identified as the stem cells of the central nervous system.
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February 2004

[Diagnosis and treatment for subarachnoid hemorrhage patients].

Zhonghua Yi Xue Za Zhi 2003 Jan;83(1):3-5

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January 2003
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