Publications by authors named "Ya Yang"

398 Publications

Triclinic Layered AZnSiS (A = Rb and Cs) with Large Optical Anisotropy and Systematic Research on the Inherent Structure-Performance Relationship in the AMMQ Family.

Inorg Chem 2021 Jul 28. Epub 2021 Jul 28.

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.

Two triclinic AZnSiS (A = Rb and Cs) with layered structures were successfully synthesized, and their physicochemical performances including optical bandgap, thermal behavior, and optical anisotropy were investigated. AZnSiS could be viewed as the first discovered Si-based examples in the known AMMQ family (2-1-3-8 system; A = monovalent alkali metal; M = divalent transition metal; M = group 14 metal; Q = chalcogen). The AMMQ family members crystallize in five different space groups (1̅, 2, 2/, 222, and 3̅), and their structural transformation and optical performances (bandgap, NLO coefficient, and birefringence) were systematically studied based on the first-principles calculation among 13 AMMQ (M = Zn, Cd, and Hg) compounds without cubic β-KZnSnS. Research result shows that the above 13 compounds exhibit the layered structures, but diverse wavelike layers and their optical anisotropy (Δ) undergo an increasing trend range from the triclinic to orthorhombic systems. Moreover, 222 compounds have very weak NLO effects compared with those of the 2 compounds since the polarization directions of anionic groups (MQ and MQ) in 222 compounds are directing oppositely and almost completely canceled out by the dipole moment calculation, which further indicates that 2 compounds exhibiting the relatively strong NLO effect and large optical anisotropy could be expected as potential IR NLO candidates.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.1c01886DOI Listing
July 2021

Frequency-Specific Alterations in Brain Function in Patients with Primary Dysmenorrhea.

Pain Med 2021 Jul 26. Epub 2021 Jul 26.

Acupuncture and Brain Science Research Center, A, cupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objective: Recent neuroimaging studies have found that brain function is abnormal in primary dysmenorrhea (PDM). The present study aimed to explore frequency-specific brain alterations and their occurrence in the PDM.

Methods: Forty-seven patients with PDM and 36 matched healthy controls were enrolled in the study and underwent resting-state functional magnetic resonance imaging. The alterations in brain function in patients with PDM were assessed using different frequency filter bands (Slow5, Slow4, Slow3, and full low frequency) and functional connectivity density (FCD) approach. The clinical significance of the altered FCD was then explored. Additionally, mediation analysis was employed to detect the altered FCD-mediated clinical relationships in PDM.

Results: Frequency-specific FCD alterations have been observed in patients with PDM, especially in the central executive, default mode, sensorimotor networks, and the hippocampus. The altered full low-frequency FCD in the hippocampus was associated with the duration of disease and pain severity scores. The altered Slow 5 FCD in the second somatosensory area (S2) was associated with the severity of pain in PDM. Furthermore, the FCD in S2 mediated the duration associated with pain symptoms in PDM.

Conclusion: The present study identified frequency-specific FCD alterations in PDM and suggested that the S2 area is a potential treatment target for PDM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/pm/pnab225DOI Listing
July 2021

Corrigendum: Identification of a Potential miRNA-mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF.

Front Mol Biosci 2021 29;8:705683. Epub 2021 Jun 29.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

[This corrects the article DOI: 10.3389/fmolb.2021.657631.].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmolb.2021.705683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276013PMC
June 2021

Differences and Similarities of Photocatalysis and Electrocatalysis in Two-Dimensional Nanomaterials: Strategies, Traps, Applications and Challenges.

Nanomicro Lett 2021 Jul 15;13(1):156. Epub 2021 Jul 15.

Beijing Key Laboratory of Micro-Nano Energy and Sensor, CAS Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, People's Republic of China.

Photocatalysis and electrocatalysis have been essential parts of electrochemical processes for over half a century. Recent progress in the controllable synthesis of 2D nanomaterials has exhibited enhanced catalytic performance compared to bulk materials. This has led to significant interest in the exploitation of 2D nanomaterials for catalysis. There have been a variety of excellent reviews on 2D nanomaterials for catalysis, but related issues of differences and similarities between photocatalysis and electrocatalysis in 2D nanomaterials are still vacant. Here, we provide a comprehensive overview on the differences and similarities of photocatalysis and electrocatalysis in the latest 2D nanomaterials. Strategies and traps for performance enhancement of 2D nanocatalysts are highlighted, which point out the differences and similarities of series issues for photocatalysis and electrocatalysis. In addition, 2D nanocatalysts and their catalytic applications are discussed. Finally, opportunities, challenges and development directions for 2D nanocatalysts are described. The intention of this review is to inspire and direct interest in this research realm for the creation of future 2D nanomaterials for photocatalysis and electrocatalysis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40820-021-00681-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282827PMC
July 2021

Reflections on the aconitine poisoning.

J Forensic Sci 2021 Jul 8. Epub 2021 Jul 8.

Shanghai Key Laboratory of Forensic Medicine (Academy of Forensic Science).

Aconitine is a natural toxic substance belonging to the family of aconitum alkaloids, which is used in small doses by Traditional Chinese practitioners. We present a case of accidental death due to acute aconitine poisoning. A 65-year-old Chinese man presented to a medical clinic with fever and shoulder pain. Soon after administration of intravenous ceftriaxone, a bottle of Chinese medicinal wine was administered. The man rapidly experienced headache, hearing loss and tinnitus, nausea, diarrhea, numbness of the lips, tongue, face, and the upper and lower extremities, cold sweat, fall of blood pressure, and discomfort of the entire body, and he died on the same day. Postmortem examination showed cyanosis of the nail beds, severe congestion in lungs and other organs, bilateral pleural effusions, and infiltration of basophils in the intestinal submucosa. No significant increase of IgE was found in the blood. Toxicological analysis detected aconitine in the medicinal wine, blood, and stomach contents by liquid chromatography-tandem mass spectrometry (LC-MS⁄MS). Aconitine was quantified in cardiac blood as 16.4 ng/ml, and in stomach contents (63.8 ng/ml) and wine sample (10.1 ug/ml). The cause of death was aconitine poisoning. This case report highlights the danger of aconitine. LC-MS⁄MS has the advantages of high analytic speed, sensitivity, and accuracy. It would be desirable for the government to control the use of aconitine-containing herbal extracts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.14766DOI Listing
July 2021

Growth, Properties and Applications of BiNaTiO Ferroelectric Nanomaterials.

Nanomaterials (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, China.

The emerging demands for miniaturization of electronics has driven the research into various nanomaterials. Lead-free BiNaTiO (BNT) ferroelectric nanomaterials have drawn great interest owing to their superiorities of large remanent polarization, high pyroelectric and piezoelectric coefficients, unique photovoltaic performance and excellent dielectric properties. As attractive multifunctional ferroelectrics, BNT nanomaterials are widely utilized in various fields, such as energy harvest, energy storage, catalysis as well as sensing. The growing desire for precisely controlling the properties of BNT nanomaterials has led to significant advancements in material design and preparation approaches. BNT ferroelectric nanomaterials exhibit significant potential in fabrication of electronic devices and degradation of waste water, which pushes forward the advancement of the Internet of things and sustainable human development. This article presents an overview of research progresses of BNT ferroelectric nanomaterials, including growth, properties and applications. In addition, future prospects are discussed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano11071724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307907PMC
June 2021

Physician-Pharmacist Collaborative Clinic Model to Improve Anticoagulation Quality in Atrial Fibrillation Patients Receiving Warfarin: An Analysis of Time in Therapeutic Range and a Nomogram Development.

Front Pharmacol 2021 9;12:673302. Epub 2021 Jun 9.

Department of Pharmacy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Poor time in therapeutic range (TTR) control is associated with an increased risk of stroke and bleeding in atrial fibrillation (AF) patients receiving warfarin. This study aimed to determine whether the physician-pharmacist collaborative clinic (PPCC) model could improve the anticoagulation quality as well as to create a nomogram for predicting anticoagulation quality in AF patients. This retrospective observational study enrolled AF patients who either initially received warfarin or returned to warfarin after withdrawal between January 1, 2016 and January 1, 2021, at our institution. The primary outcome was dynamic changes in TTRs (a TTR of ≥60% considered high anticoagulation quality). The secondary outcomes were thromboembolic and bleeding events during follow-up. We compared the dynamic changes in TTRs between the general clinic (GC) and PPCC groups in both the original and propensity score matching (PSM) cohorts. In addition, we explored the potential predictors of high anticoagulation quality and subsequently formulated a nomogram to predict anticoagulation quality. A total of 265 patients with AF were included, comprising 57 patients in the PPCC group and 208 patients in the GC group. During a median follow-up period of 203 days, the PPCC group had a shorter time (76 vs. 199 days, < 0.001) and more patients achieved a TTR ≥60% (73.7 vs. 47.1%, = 0.002 by log-rank test) than the GC group. The results from the PSM cohort confirmed this finding. No significant differences in the incidences of thromboembolic events (5.3 vs. 5.3%, = 1.000) and bleeding events (4.3 vs. 3.5%, = 1.000) were observed between the two groups. Four variables were explored as predictors related to high anticoagulation quality: treatment within a PPCC, history of bleeding, history of bleeding, and the presence of more than four comorbidities. The nomogram revealed a moderate predictive ability (c-index: 0.718, 95% confidence interval (95%CI): 0.669-0.767) and a moderately fitted calibration curve. The PPCC model contributed to improved anticoagulation quality in AF patients receiving warfarin. The nomogram might be an effective tool to predict anticoagulation quality and could aid physicians and pharmacists in the selection of patients who will likely benefit from sustained and active intervention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2021.673302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220138PMC
June 2021

Divergence of the genetic contribution of FRIGIDA homologues in regulating the flowering time in Brassica rapa ssp. rapa.

Gene 2021 Sep 25;796-797:145790. Epub 2021 Jun 25.

Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Plant Germplasm and Genomics Center, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2021.145790DOI Listing
September 2021

Cryotherapy is effective for treatment of oral verrucous hyperplasia - Case report.

J Dent Sci 2021 Jul 6;16(3):1025-1026. Epub 2021 Jan 6.

Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jds.2020.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189883PMC
July 2021

Speckle-Tracking Echocardiography for Detecting Subclinical Left Ventricular Dysfunction in Patients With Familial Hypercholesterolemia.

Tex Heart Inst J 2021 06;48(2)

Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People's Republic of China.

Myocardial ischemia and left ventricular dysfunction have been documented in young adults with familial hypercholesterolemia. We investigated whether speckle-tracking echocardiography can be used to detect subclinically impaired global and regional myocardial function in patients with this lipid disorder. This single-center study included 47 patients with familial hypercholesterolemia and 37 healthy control subjects who underwent transthoracic Doppler echocardiography and speckle-tracking echocardiography from January 2003 through December 2016. Conventional echocardiographic and strain parameters in the 2 groups were analyzed and compared. Left ventricular dimensions were significantly larger at end-diastole (P=0.02) and end-systole (P=0.013), left ventricular walls were significantly thicker (P <0.0001), and the early transmitral/early diastolic mitral annular velocity ratio was significantly higher (P=0.006) in the patient group than in the control group. In the patient group, global longitudinal and circumferential strain values were significantly lower (P <0.0001) and global radial strain values significantly higher (P=0.006); all segmental longitudinal strain (P <0.04) and most segmental circumferential strain values (P ≤0.01) were significantly lower; and some segmental radial strains, especially at the apex, were significantly higher (P ≤0.04). However, average longitudinal, circumferential, and radial strains in the different segments of the 3 main coronary artery territories were significantly lower in the patient group (P <0.01). Global longitudinal strain (r=0.561; P=0.001) and global circumferential strain (r=0.565; P <0.0001) were inversely correlated with low-density-lipoprotein cholesterol levels. We conclude that speckle-tracking echocardiography can be used to detect subclinical global and regional systolic abnormalities in patients with familial hypercholesterolemia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.14503/THIJ-18-6720DOI Listing
June 2021

2D Nanomaterials for Effective Energy Scavenging.

Nanomicro Lett 2021 Mar 3;13(1):82. Epub 2021 Mar 3.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, People's Republic of China.

The development of a nation is deeply related to its energy consumption. 2D nanomaterials have become a spotlight for energy harvesting applications from the small-scale of low-power electronics to a large-scale for industry-level applications, such as self-powered sensor devices, environmental monitoring, and large-scale power generation. Scientists from around the world are working to utilize their engrossing properties to overcome the challenges in material selection and fabrication technologies for compact energy scavenging devices to replace batteries and traditional power sources. In this review, the variety of techniques for scavenging energies from sustainable sources such as solar, air, waste heat, and surrounding mechanical forces are discussed that exploit the fascinating properties of 2D nanomaterials. In addition, practical applications of these fabricated power generating devices and their performance as an alternative to conventional power supplies are discussed with the future pertinence to solve the energy problems in various fields and applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40820-021-00603-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006560PMC
March 2021

Piezoelectric Materials for Controlling Electro-Chemical Processes.

Nanomicro Lett 2020 Jul 14;12(1):149. Epub 2020 Jul 14.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, People's Republic of China.

Piezoelectric materials have been analyzed for over 100 years, due to their ability to convert mechanical vibrations into electric charge or electric fields into a mechanical strain for sensor, energy harvesting, and actuator applications. A more recent development is the coupling of piezoelectricity and electro-chemistry, termed piezo-electro-chemistry, whereby the piezoelectrically induced electric charge or voltage under a mechanical stress can influence electro-chemical reactions. There is growing interest in such coupled systems, with a corresponding growth in the number of associated publications and patents. This review focuses on recent development of the piezo-electro-chemical coupling multiple systems based on various piezoelectric materials. It provides an overview of the basic characteristics of piezoelectric materials and comparison of operating conditions and their overall electro-chemical performance. The reported piezo-electro-chemical mechanisms are examined in detail. Comparisons are made between the ranges of material morphologies employed, and typical operating conditions are discussed. In addition, potential future directions and applications for the development of piezo-electro-chemical hybrid systems are described. This review provides a comprehensive overview of recent studies on how piezoelectric materials and devices have been applied to control electro-chemical processes, with an aim to inspire and direct future efforts in this emerging research field.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40820-020-00489-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770897PMC
July 2020

The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues.

Front Med (Lausanne) 2021 31;8:655268. Epub 2021 May 31.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2021.655268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200416PMC
May 2021

A universal managing circuit with stabilized voltage for maintaining safe operation of self-powered electronics system.

iScience 2021 May 4;24(5):102502. Epub 2021 May 4.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.

Harvesting mechanical energy via a triboelectric nanogenerator (TENG) is a promising strategy for solving energy problems. However, it is necessary to develop an effective and safe energy managing circuit for preventing high voltage breaking electronic devices. Here, a universal managing circuit is developed to optimize TENG's output performance, which for the first time allows the TENG to safely power various sensor systems with a safe and stable voltage. Based on the circuit, TENG's output can be transformed into a stable voltage with tunable amplitude, while an enhanced short-circuit current of 94 mA with an energy loss lower than 5% is achieved. For demonstrations, three different types of TENGs, respectively, targeting at ocean energy, wind energy, and walking energy have been prepared to reveal the capability of the circuit. This study offers a strategy to greatly enhance the output performance of TENGs to provide useful guidance for constructing self-powered and distributed sensor systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2021.102502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170003PMC
May 2021

Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study.

Front Neurosci 2021 24;15:647667. Epub 2021 May 24.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Primary dysmenorrhea (PDM) is a common gynecological disease characterized by lower abdominal pain. Acupuncture is considered a good alternative therapy for PDM. However, the central mechanism of the analgesic effect of acupuncture is largely unknown. In this study, eligible patients were randomized into the real and sham acupuncture groups using a computer-generated, permuted block randomization method. The study cohort comprised 34 patients: 19 in the real acupuncture group and 15 in the sham acupuncture group. The clinical characteristics of the patients during their menstrual period were collected, and imaging scans were performed during the first 3 days of the patients' menstrual period. We analyzed task and resting functional magnetic resonance imaging (fMRI) data to investigate the potential central mechanism of the immediate effect of acupuncture intervention on the intensity of PDM pain. The task fMRI study found that the rostral anterior cingulate cortex (rACC) and right supplemental motor area were activated during real acupuncture. Using the resting-state functional connectivity (FC) method, we found a post- versus pre-treatment change in the FC of the rACC and left precentral gyrus in the comparison of real acupuncture versus sham acupuncture. In addition, the FC of the rACC-left precentral gyrus at baseline was negatively correlated with short-term analgesia, while the change in the FC of the rACC-left precentral gyrus was positively correlated with short-term analgesia after acupuncture treatment. These findings support the importance of rACC-left precentral gyrus resting-state FC in the modulation of the intensity of PDM pain through acupuncture, which may shed light on the central mechanism of acupuncture in the treatment of PDM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2021.647667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180846PMC
May 2021

Comparative transcriptomics analysis reveals differential Cd response processes in roots of two turnip landraces with different Cd accumulation capacities.

Ecotoxicol Environ Saf 2021 Sep 5;220:112392. Epub 2021 Jun 5.

Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Xishuangbanna 666303, China. Electronic address:

Understanding the molecular mechanisms of cadmium (Cd) tolerance and accumulation in plants is important to address Cd pollution. In the present study, we performed comparative transcriptome analysis to identify the Cd response processes in the roots of two turnip landraces, KTRG-B14 (high-Cd accumulation) and KTRG-B36 (low-Cd accumulation). Two common enhanced processes, glutathione metabolism and antioxidant system, were identified in both landraces. However, some differential antioxidant processes are likely employed by two landraces, namely, several genes encoding peptide methionine sulfoxide reductases and thioredoxins were up-regulated in B14, whereas flavonoid synthesis was potentially induced to fight against oxidative stress in B36. In addition to the commonly upregulated ZINC INDUCED FACILITATOR 1-like gene in two landraces, different metal transporter-encoding genes identified in B14 (DETOXIFICATION 1) and B36 (PLANT CADMIUM RESISTANCE 2-like, probable zinc transporter 10, and ABC transporter C family member 3) were responsible for Cd accumulation and distribution in cells. Several genes that encode extensins were specifically upregulated in B14, which may improve Cd accumulation in cell walls or regulate root development to absorb more Cd. Meanwhile, the induced high-affinity nitrate transporter 2.1-like gene was also likely to contribute to the higher Cd accumulation in B14. However, Cd also caused some toxic symptoms in both landraces. Cd stress might inhibit iron uptake in both landraces whereas many apoenzyme-encoding genes were influenced in B36, which may be attributed to the interaction between Cd and other metal ions. This study provides novel insights into the molecular mechanism of plant root response to Cd at an early stage. The transporters and key enzymes identified in this study are helpful for the molecular-assisted breeding of low- or high-Cd-accumulating plant resources.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2021.112392DOI Listing
September 2021

Emerging nanogenerators: Powering the Internet of Things by high entropy energy.

iScience 2021 May 26;24(5):102358. Epub 2021 Apr 26.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2021.102358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169694PMC
May 2021

Study on the Dynamic Recrystallization Behavior of 47Zr-45Ti-5Al-3V Alloy by CA-FE Simulation.

Materials (Basel) 2021 May 14;14(10). Epub 2021 May 14.

Guizhou Key Laboratory of Materials Mechanical Behavior and Microstructure, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China.

The dynamic recrystallization (DRX) behavior of 47Zr-45Ti-5Al-3V alloy was studied by using the experiment and numerical simulation method based on DEFORM-3D software and cellular automata (CA) over a range of deformation temperatures (850 to 1050 °C) and strain rates (10 to 10 s). The results reveal that the DRX behavior of 47Zr-45Ti-5Al-3V alloy strongly depends on hot-working parameters. With rising deformation temperature () and decreasing strain rate (ε˙), the grain size (dDRX) and volume fraction (XDRX) of DRX dramatically boost. The kinetics models of the dDRX and XDRX of DRX grains were established. According to the developed kinetics models for DRX of 47Zr-45Ti-5Al-3V alloy, the distributions of the dDRX and XDRX for DRX grains were predicted by DEFORM-3D. DRX microstructure evolution is simulated by CA. The correlation of the kinetics model is verified by comparing the dDRX and XDRX between the experimental and finite element simulation (FEM) results. The nucleation and growth of dynamic recrystallization grains in 47Zr-45Ti-5Al-3V alloy during hot-working can be simulated accurately by CA simulation, comparing with FEM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma14102562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156880PMC
May 2021

Loading Gentamicin and Zn on TiO Nanotubes to Improve Anticoagulation, Endothelial Cell Growth, and Antibacterial Activities.

Stem Cells Int 2021 3;2021:9993247. Epub 2021 May 3.

Faculty of Mechanical and Material Engineering, Huaiyin Institute of Technology, Huai'an 223003, China.

Titanium and its alloys are widely used in blood-contacting implantable and interventional medical devices; however, their biocompatibility is still facing great challenges. In the present study, in order to improve the biocompatibility and antibacterial activities of titanium, TiO nanotubes were firstly in situ prepared on the titanium surface by anodization, followed by the introduction of polyacrylic acid (PAA) and gentamicin (GS) on the nanotube surface by layer-by-layer assembly, and finally, zinc ions were loaded on the surface to further improve the bioactivities. The nanotubes displayed excellent hydrophilicity and special nanotube-like structure, which can selectively promote the albumin adsorption, enhance the blood compatibility, and promote the growth of endothelial cells to some degree. After the introduction of PAA and GS, although the superhydrophilicity cannot be achieved, the results of platelet adhesion, cyclic guanosine monophosphate (cGMP) activity, hemolysis rate, and activated partial thromboplastin time (APTT) showed that the blood compatibility was improved, and the blood compatibility was further enhanced after zinc ion loading. On the other hand, the modified surface showed good cytocompatibility to endothelial cells. The introduction of PAA and zinc ions not only promoted the adhesion and proliferation of endothelial cells but also upregulated expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The slow and continuous release of GS and Zn over 14 days can significantly improve the antibacterial properties. Therefore, the present study provides an effective method for the surface modification of titanium-based blood-contacting materials to simultaneously endow with good blood compatibility, endothelial growth behaviors, and antibacterial properties.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/9993247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112940PMC
May 2021

Integrated analysis of microRNA and mRNA expression profiles in homozygous familial hypercholesterolemia patients and validation of atherosclerosis associated critical regulatory network.

Genomics 2021 Jul 28;113(4):2572-2582. Epub 2021 May 28.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening genetic disorder characterized by an extremely elevated serum level of low-density lipoprotein cholesterol (LDL-C) and accelerated premature atherosclerotic cardiovascular diseases (ASCVD). However, the detailed mechanism of how the pathogenic mutations of HoFH trigger the acceleration of ASCVD is not well understood. Therefore, we performed high-throughput RNA and small RNA sequencing on the peripheral blood RNA samples of six HoFH patients and three healthy controls. The gene and miRNA expression differences were analyzed, and seven miRNAs and six corresponding genes were screened out through regulatory network analysis. Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR-486-3p, hsa-miR-941, and BIRC5 were significantly upregulated in HoFH, while ID1, PLA2G4C, and CACNA2D2 were downregulated. Spearman correlation analysis found that the levels of ID1, hsa-miR-941, and hsa-miR-486-3p were significantly correlated with additional ASCVD risk factors in HoFH patients. This study represents the first integrated analysis of transcriptome and miRNA expression profiles in patients with HoFH, a rare disease, and as a result, six differentially expressed miRNAs/genes that may be related to atherosclerosis in HoFH are reported. The miRNA-mRNA regulatory network may be the critical regulation mechanism by which ASCVD is accelerated in HoFH.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2021.05.036DOI Listing
July 2021

Patterns of Sulcal depth and cortical thickness in Parkinson's disease.

Brain Imaging Behav 2021 May 21. Epub 2021 May 21.

Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Previous voxel-based morphometry (VBM) and cortical thickness (CT) studies on Parkinson's disease (PD) have mainly reported the gray matter size reduction, whereas the shape of cortical surface can also change in PD patients. For the first time, we analyzed sulcal depth (SD) patterns in PD patients by using whole brain region of interest (ROI)-based approach. In a cross-sectional study, high-resolution brain structural MRI images were collected from 60 PD patients without dementia and 56 age-and sex-matched healthy controls (HC). SD and CT were estimated using the Computational Anatomy Toolbox (CAT12) and statistically compared between groups on whole brain ROI-based level using statistical parametric mapping 12 (SPM12). Additionally, correlations between regional brain changes and clinical variables were also examined. Compared to HC, PD patients showed lower SD in widespread regions, including temporal (the bilateral transverse temporal, the left inferior temporal, the right middle temporal and the right superior temporal), insular (the left insula), frontal (the left pars triangularis, the left pars opercularis and the left precentral), parietal (the bilateral superior parietal) and occipital (the right cuneus) regions. For CT, only the left pars opercularis showed lower CT in PD patients compared to HC. No regions showed higher SD or CT in PD patients compared to HC. In PD patients, a significant positive correlation was found between SD of the left pars opercularis and MMSE scores, such that lower MMSE scores were related to lower SD of the left pars opercularis. Our results of widespread lower SD, but relatively localized lower CT, indicate that SD seems to be more sensitive to brain changes than CT and may be mainly affected by white matter damage. Hence, SD may be a more promising indicator to investigate the surface shape changes in PD patients. The significant positive correlation between SD of the left pars opercularis and MMSE scores suggests that SD may be prognostic of future cognitive decline.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11682-020-00428-xDOI Listing
May 2021

Fiber-Shaped Triboiontronic Electrochemical Transistor.

Research (Wash D C) 2021 26;2021:9840918. Epub 2021 Apr 26.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Contact electrification-activated triboelectric potential offers an efficient route to tuning the transport properties in semiconductor devices through electrolyte dielectrics, i.e., triboiontronics. Organic electrochemical transistors (OECTs) make more effective use of ion injection in the electrolyte dielectrics by changing the doping state of the semiconductor channel. However, the mainstream flexible/wearable electronics and OECT-based devices are usually modulated by electrical signals and constructed in conventional geometry, which lack direct and efficient interaction between the external environment and functional electronic devices. Here, we demonstrate a fiber-shaped triboiontronic electrochemical transistor with good electrical performances, including a current on/off ratio as high as ≈1286 with off-current at ~nA level, the average threshold displacements ( ) of 0.3 mm, the subthreshold swing corresponding to displacement (SS) at 1.6 mm/dec, and excellent flexibility and durability. The proposed triboiontronic electrochemical transistor has great potential to be used in flexible, functional, and smart self-powered electronic textile.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.34133/2021/9840918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098052PMC
April 2021

Development of a patient safety care activity scale for clinical nurses in Korea.

Authors:
Ya Ki Yang

Arch Public Health 2021 May 17;79(1):79. Epub 2021 May 17.

Department of Nursing, College of Medicine, Wonkwang University, #460 Iksan-daero, Iksan City, Jeollabukdo, 54538, South Korea.

Background: The aim of this study was to develop a scale to measure patient safety care activities for clinical nurses and to verify validity and reliability it.

Methods: Literature review and expert consultation were utilized to develop the scale of the Patient Safety Care Activities. The validity and reliability analyses were conducted with 428 nurses working at 5 general hospitals. Exploratory factor analysis of the scale was performed, and convergent and discriminant validity as well as internal consistency reliability were determined.

Results: Eight subcategories (security, patient identification, operation (invasive procedure), medication, blood transfusion, management of infection, management of falls & sores, management of firefighting) with 44 items were validated to measure patient safety care activities. Convergent and discriminant validity indicated the applicability of the eight-factor Patient Safety Care Activities scale. The reliability of the Patient Safety Care Activities Scale was acceptable, with Cronbach's a = .88 ~ .95.

Conclusion: The developed scale showed content, construct validity, and reliability, as well as convergent validity for each item and discriminant validity between the factors. This makes it suitable for use in a diverse range of future studies on patient safety care activity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13690-021-00596-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127441PMC
May 2021

Hybridized nanogenerators for effectively scavenging mechanical and solar energies.

iScience 2021 May 10;24(5):102415. Epub 2021 Apr 10.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, P. R. China.

Solar and wind energy harvesting technology is increasingly an economical and efficient energy form and receives excellent support from government policies worldwide. Various functional and structural nanogenerators based on multi-effects named hybridized nanogenerators have been reported separately or simultaneously to effectively generate the wasted mechanical and solar energy in our daily life. We review the development of hybridized nanogenerators, including the working mechanism of solar and mechanical energies. Moreover, the classification of nanogenerators for scavenging mechanical and solar energies is discussed. The potential applications of hybridized nanogenerators are reviewed. Finally, the challenge and prospective of hybridized nanogenerators and the future explored improvements of output performance, stability, preparation, large-scale utilizing, and efficiency are discussed. The hybridized nanogenerator as the energy technology will be popularized in energy and self-powered sensor systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2021.102415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099563PMC
May 2021

Identification of a Potential miRNA-mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF.

Front Mol Biosci 2021 28;8:657631. Epub 2021 Apr 28.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening disease with a high mortality rate; the systemic inflammatory response plays a vital role in disease progression. We aimed to determine if a miRNA-mRNA co-regulatory network exists in the peripheral blood mononuclear cells (PBMCs) of HBV-ACLF patients, which might be important for prognosis.

Methods: In patients with HBV-ACLF meeting COSSH-ACLF criteria, age, liver cirrhosis and INR were independent risk factors for 28-day and 90-day poor prognosis. COSSH-ACLFs was a superior prognostic model. mir-6840-3p-JADE2 may promote the progression of ACLF and lead to poor prognosis. Meanwhile, mir-6840-3p and mir-6861-3p can be used as markers of short-term poor prognosis. Finally, ALSS treatment is not only the blood material exchange of patients, but also changes part of the immune state of patients. Among them, cytokine cytokine receptor interaction may play an important role in determining the therapeutic effect.

Methods: Transcriptome-wide microRNA (miRNA) and mRNA microarrays were used to define the miRNA and mRNA expression profiles of the PBMCs of HBV-ACLF patients in a discovery cohort. The targets of the miRNAs were predicted. We built a miRNA-mRNA regulatory network through bioinformatics analysis, and used quantitative real-time polymerase chain reaction (qRT-PCR) to assess the importance of candidate miRNAs and mRNAs. We also assessed the direct and transcriptional regulatory effects of miRNAs on target mRNAs using a dual-luciferase reporter assay.

Results: The miRNA/mRNA PBMC expression profiles of the discovery cohort, of whom eight survived and eight died, revealed a prognostic interactive network involving 38 miRNAs and 313 mRNAs; this was constructed by identifying the target genes of the miRNAs. We validated the expression data in another cohort, of whom 43 survived and 35 died; miR-6840-3p, miR-6861-3p, JADE2, and NR3C2 were of particular interest. The levels of miR-6840-3p and miR-6861-3p were significantly increased in the PBMCs of the patients who died, and thus predicted prognosis (areas under the curve values = 0.665 and 0.700, respectively). The dual-luciferase reporter assay indicated that miR-6840-3p directly targeted JADE2.

Conclusion: We identified a prognostic miRNA-mRNA co-regulatory network in the PBMCs of HBV-ACLF patients. miR-6840-3p-JADE2 is a potential miRNA-mRNA pair contributing to a poor prognosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmolb.2021.657631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113841PMC
April 2021

Analysis of paralogs in target enrichment data pinpoints multiple ancient polyploidy events in Alchemilla s.l. (Rosaceae).

Syst Biol 2021 May 12. Epub 2021 May 12.

Department of Plant and Microbial Biology, University of Minnesota-Twin Cities, 1445 Gortner Avenue, St. Paul, MN 55108, USA.

Target enrichment is becoming increasingly popular for phylogenomic studies. Although baits for enrichment are typically designed to target single-copy genes, paralogs are often recovered with increased sequencing depth, sometimes from a significant proportion of loci, especially in groups experiencing whole-genome duplication (WGD) events. Common approaches for processing paralogs in target enrichment data sets include random selection, manual pruning, and mainly, the removal of entire genes that show any evidence of paralogy. These approaches are prone to errors in orthology inference or removing large numbers of genes. By removing entire genes, valuable information that could be used to detect and place WGD events is discarded. Here we used an automated approach for orthology inference in a target enrichment data set of 68 species of Alchemilla s.l. (Rosaceae), a widely distributed clade of plants primarily from temperate climate regions. Previous molecular phylogenetic studies and chromosome numbers both suggested ancient WGDs in the group. However, both the phylogenetic location and putative parental lineages of these WGD events remain unknown. By taking paralogs into consideration and inferring orthologs from target enrichment data, we identified four nodes in the backbone of Alchemilla s.l. with an elevated proportion of gene duplication. Furthermore, using a gene-tree reconciliation approach we established the autopolyploid origin of the entire Alchemilla s.l. and the nested allopolyploid origin of four major clades within the group. Here we showed the utility of automated tree-based orthology inference methods, previously designed for genomic or transcriptomic data sets, to study complex scenarios of polyploidy and reticulate evolution from target enrichment data sets.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/sysbio/syab032DOI Listing
May 2021

Back to the future: Reintegrating biology to understand how past eco-evolutionary change can predict future outcomes.

Integr Comp Biol 2021 May 8. Epub 2021 May 8.

Department of Plant and Microbial Biology, University of Minnesota,

During the last few decades, biologists have made remarkable progress in understanding the fundamental processes that shape life. But despite the unprecedented level of knowledge now available, large gaps still remain in our understanding of the complex interplay of eco-evolutionary mechanisms across scales of life. Rapidly changing environments on Earth provide a pressing need to understand the potential implications of eco-evolutionary dynamics, which can be achieved by improving existing eco-evolutionary models and fostering convergence among the sub-fields of biology. We propose a new, data-driven approach that harnesses our knowledge of the functioning of biological systems to expand current conceptual frameworks and develop corresponding models that can more accurately represent and predict future eco-evolutionary outcomes. We suggest a roadmap toward achieving this goal. This long-term vision will move biology in a direction that can wield these predictive models for scientific applications that benefit humanity and increase the resilience of natural biological systems. We identify short, medium, and long-term key objectives to connect our current state of knowledge to this long-term vision, iteratively progressing across three stages: 1) utilizing knowledge of biological systems to better inform eco-evolutionary models, 2) generating models with more accurate predictions, and 3) applying predictive models to benefit the biosphere. Within each stage, we outline avenues of investigation and scientific applications related to the timescales over which evolution occurs, the parameter space of eco-evolutionary processes, and the dynamic interactions between these mechanisms. The ability to accurately model, monitor, and anticipate eco-evolutionary changes would be transformational to humanity's interaction with the global environment, providing novel tools to benefit human health, protect the natural world, and manage our planet's biosphere.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/icb/icab068DOI Listing
May 2021

Inhibitory Effect of Astragalus Polysaccharide Combined with Cisplatin on Cell Cycle and Migration of Nasopharyngeal Carcinoma Cell Lines.

Biol Pharm Bull 2021 Jul 29;44(7):926-931. Epub 2021 Apr 29.

School of Medicine, Jiaying University.

Background Astragalus polysaccharide (APS) had shown great promise in anti-tumour activities in our previous studies. The present study was designed to investigate whether APS has synergistic effect with cisplatin on the growth-inhibitory of human nasopharyngeal carcinoma cell lines and the possible mechanism. Methods Here, nasopharyngeal carcinoma cell lines (CNE-1) were divided into CNE-1 group, Cisplatin treatment group (2 µg/mL Cisplatin), APS treatment group (200 µg/mL APS) and combination group (2 µg/mL Cisplatin and 200 µg/mL APS). The proliferation inhibition rate of CNE-1 cells was determined by Cell Counting Kit-8 (CCK-8) method after treatment with different concentrations of APS for 24, 48, and 72 h. Apoptosis rates and cell cycle retardation of cells were detected by flow cytometry. Cell migration and invasion was evaluated by transwell assay. Western blotting and quantitative (q)RT-PCR were performed to detect the expression of Bcl-2, Bax, caspase-3, matrix metalloproteinase-2 (MMP-2), p53 and matrix metalloproteinase-9 (MMP-9) proteins in CNE-1 cells. Results APS have an inhibition on the proliferation of CNE-1 cells with time and dose dependence manner. Both the APS and combination therapy could promote apoptosis of CNE-1 cells, with the count of cells increased in G0/G1 and S phase while decreased in G2/M phase, and inhibited the migration and invasion of CNE-1 cells. Moreover, co-administration of Cisplatin and APS was more efficacious for the antitumor effect than either agent alone, as evidenced by the significant decrease in MMP-9 level and increase in p53. Conclusion APS, in combination with cisplatin, had significantly synergistic growth-inhibitory effect on nasopharyngeal carcinoma cell lines, which may be related to cell cycle and migration induction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b20-00959DOI Listing
July 2021

Low-Temperature Induced Enhancement of Photoelectric Performance in Semiconducting Nanomaterials.

Nanomaterials (Basel) 2021 Apr 27;11(5). Epub 2021 Apr 27.

Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

The development of light-electricity conversion in nanomaterials has drawn intensive attention to the topic of achieving high efficiency and environmentally adaptive photoelectric technologies. Besides traditional improving methods, we noted that low-temperature cooling possesses advantages in applicability, stability and nondamaging characteristics. Because of the temperature-related physical properties of nanoscale materials, the working mechanism of cooling originates from intrinsic characteristics, such as crystal structure, carrier motion and carrier or trap density. Here, emerging advances in cooling-enhanced photoelectric performance are reviewed, including aspects of materials, performance and mechanisms. Finally, potential applications and existing issues are also summarized. These investigations on low-temperature cooling unveil it as an innovative strategy to further realize improvement to photoelectric conversion without damaging intrinsic components and foresee high-performance applications in extreme conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano11051131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147110PMC
April 2021

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1.

J Neurosci 2021 May 22;41(21):4596-4606. Epub 2021 Apr 22.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan

Pain at the injection site is a common complaint of patients receiving therapeutic formulations containing citric acid. Despite the widely acknowledged role of acid-sensing ion channels (ASICs) in acid-related perception, the specific ASIC subtype mediating pain caused by subcutaneous acid injection and the mechanism by which citrate affects this process are less clear. Here, male mice subjected to intraplantar acid injection responded by executing a withdrawal reflex, and this response was abolished by ASIC1 but not ASIC2 knockout. Although intraplantar injection of neutral citrate solution did not produce this response, intraplantar injection of acidic citrate solution produced a withdrawal reflex greater than that produced by acidity alone. Consistent with the behavioral data, neutral citrate failed to produce an electrophysiological response in HEK293 cells, which express ASIC1, but acidic citrate produced a whole-cell inward current greater than that produced by acidity alone. Saturating the intracellular solution with citrate had no effect on the potentiating effect of extracellular citrate, suggesting that citrate acted extracellularly to potentiate ASIC1. Moreover, exposure to citrate immediately before acid stimulation failed to potentiate ASIC1 currents, which ruled out the involvement of a metabotropic receptor gated by a citrate metabolite. Finally, removal of calcium ions from the extracellular solution mimicked the potentiating effect of citrate and prevented citrate from further potentiating ASIC1. Our data demonstrate that ASIC1 is necessary for the nociceptive response caused by subcutaneous acid infusion and that neutral citrate, despite not inducing ASIC1 currents or nociceptive behavior on its own, potentiates acid nociception by removing the inhibitory effect of extracellular calcium ions on ASIC1. Citric acid is a common ingredient used in pharmaceutical formulations. Despite the widespread clinical use of these formulations, it remains unclear how citric acid causes pain when injected into patients. We identified ASIC1 as the key receptor used to detect injection-site pain caused by acid, and we showed that neutral citrate does not stimulate ASIC1; instead, citrate substantially potentiates ASIC1 activation when injected simultaneously with acid. In addition, we demonstrated that citrate potentiates ASIC1 by removing the inhibitory action of calcium on the extracellular side of the receptor. Given that injection-site pain is the primary complaint of patients receiving citrate-containing medical products, our data provide mechanistic insight into a common medical complaint and suggest a means of avoiding injection pain.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2087-20.2021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260239PMC
May 2021
-->