Publications by authors named "Ya Xiong"

62 Publications

Asymmetric construction of six vicinal stereogenic centers on hexahydroxanthones organocatalytic one-pot reactions.

Chem Commun (Camb) 2021 Jul;57(55):6764-6767

National & Local Joint Engineering Research Center for the Exploition of Homology Resources of Medicine and Food, Guizhou University, Guiyang, Guizhou 550025, P. R. China.

Inspired by the chemistry and biology of hexahydroxanthones, herein we report an organocatalytic Michael-Michael-Aldol-decarboxylation reaction that provides efficient access to biologically interesting fully substituted hexahydroxanthones bearing six contiguous stereogenic centers from readily accessible materials in acceptable yields (up to 63%) and excellent stereoselectivities (up to 10 : 1 dr and >99% ee). In other words, the reaction efficiently produces three chemical bonds and up to six vicinal stereogenic centers in a one-pot operation. In particular, to our knowledge, this is an asymmetric organocatalytic strategy enabling the first construction of six vicinal stereogenic centers on non-spirocyclic hexahydroxanthone frameworks.
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http://dx.doi.org/10.1039/d1cc02570hDOI Listing
July 2021

The Effect of Mechanical Ventilation With Low Tidal Volume on Blood Loss During Laparoscopic Liver Resection: A Randomized Controlled Trial.

Anesth Analg 2021 04;132(4):1033-1041

From the Department of Anesthesiology.

Background: Control of bleeding during laparoscopic liver resection (LLR) is important for patient safety. It remains unknown what the effects of mechanical ventilation with varying tidal volumes on bleeding during LLR. Thus, this study aims to investigate whether mechanical ventilation with low tidal volume (LTV) reduces surgical bleeding during LLR.

Methods: In this prospective, randomized, and controlled clinical study, 82 patients who underwent scheduled LLR were enrolled and randomly received either mechanical ventilation with LTV group (6-8 mL/kg) along with recruitment maneuver (once/30 min) without positive end-expiratory pressure (PEEP) or conventional tidal volume (CTV; 10-12 mL/kg) during parenchymal resection. The estimated volume of blood loss during parenchymal resection and the incidence of postoperative respiratory complications were compared between 2 groups.

Result: The estimated volume of blood loss (median [interquartile range {IQR}]) was decreased in the LTV group compared to the CTV group (301 [148, 402] vs 394 [244, 672] mL, P = .009); blood loss per cm2 of transected surface of liver (5.5 [4.1, 7.7] vs 12.2 [9.8, 14.4] mL/cm2, P < .001) and the risk of clinically significant estimated blood loss (>800 mL) were reduced in the LTV group compared to the CTV group (0/40 vs 8/40, P = .003). Blood transfusion was decreased in the LTV group compared to the CTV group (5% vs 20% of patients, P = .043). No patient in the LTV group but 2 patients in the CTV group were switched from LLR to open hepatectomy. Airway plateau pressure was lower in the LTV group compared to the CTV group (mean ± standard deviation [SD]) (12.7 ± 2.4 vs 17.5 ± 3.5 cm H2O, P = .002).

Conclusions: Mechanical ventilation with LTV may reduce bleeding during laparoscopic liver surgery.
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http://dx.doi.org/10.1213/ANE.0000000000005242DOI Listing
April 2021

Dopamine beta-hydroxylase and its role in regulating the growth and larval metamorphosis in Sinonovacula constricta.

Gene 2020 May 14;737:144418. Epub 2020 Feb 14.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources and College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Shanghai Engineering Research Center of Aquaculture, Shanghai 201306, China. Electronic address:

Dopamine beta-hydroxylase (DβH) plays a key role in the synthesis of catecholamines (CAs) in the neuroendocrine regulatory network. The DβH gene was identified from the razor clam Sinonovacula constricta and referred to as ScDβH. The ScDβH gene is a copper type II ascorbate-dependent monooxygenase with a DOMON domain and two Cu2_monooxygen domains. ScDβH transcript expression was abundant in liver and hemolymph. During early development, ScDβH expression significantly increased at the umbo larval stage. Furthermore, the inhibitors and siRNA of DβH were screened. After challenge with DβH inhibitor, the larval metamorphosis and survival rates, and juvenile growth were obviously decreased. Under the siRNA stress, the larval metamorphosis and survival rates were also significantly decreased. Therefore, ScDβH may play an important regulating role in larval metamorphosis and juvenile growth.
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http://dx.doi.org/10.1016/j.gene.2020.144418DOI Listing
May 2020

A Laboratory-Built Fully Automated Ultrasonication Robot for Filamentous Fungi Homogenization.

SLAS Technol 2019 12 30;24(6):583-595. Epub 2019 Jul 30.

Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.

This article presents the design and development of a new hands-free ultrasonication robot for filamentous fungi homogenization. The platform was constructed with a modified inexpensive 3D printer, equipped with an upward-facing camera, a custom-designed wash station, and an add-on sonicator. While machine vision accomplished sample well screening based on image subtraction and color thresholding, it also determined the level of fungi homogeneity using color variance. Model fitting reveals that the process of filamentous fungi homogenization using ultrasonication included a period of significant exponential decay. Therefore, this procedure allowed for the rapid homogenization of the fungal samples during the initial stages of ultrasonication treatment followed by a deceleration in homogenization. Furthermore, a factorial experiment showed that higher sonicator power and temperature accelerated the homogenization process, while the cultivation time exhibited no effect on homogenization. In addition, the model parameters were varied between the wells, even when subjected to the same settings, meaning that the system cannot use the same asymptote of the homogeneity level to establish the termination time for different wells. Therefore, we used the standard deviation of the four most recent homogeneity level values to determine the termination time. This method was used for feedback control, forming a fully automated robot that did not require manual intervention during the experiment. A validation test on filamentous fungi demonstrated that the system was able to provide target quality of samples efficiently.
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http://dx.doi.org/10.1177/2472630319861361DOI Listing
December 2019

A hierarchical structured steel mesh decorated with metal organic framework/graphene oxide for high-efficient oil/water separation.

J Hazard Mater 2019 Jul 2;373:725-732. Epub 2019 Apr 2.

State Key Laboratory of Petroleum Pollution Control, China University of Petroleum, Qingdao 266555, Shandong, PR China; School of Materials Science and Engineering, China University of Petroleum, Qingdao 266580, Shandong, PR China; State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266555, Shandong, PR China. Electronic address:

A hierarchical structured steel mesh decorated with metal organic framework (UiO-66-NH) nanoparticles/graphene oxide (GO) nanosheets was successfully prepared via a simple self-assemble method. Because water molecules tend to build hydrogen bonds with the amine, carboxyl and hydroxyl functional groups of UiO-66-NH/GO hierarchical structure, the hierarchical structure can easily capture water and tightly lock the water to build a stable water layer on the steel mesh surface and block oil in contact with the steel mesh. Therefore, the obtained hierarchical structured steel mesh exhibits super-hydrophilicity, underwater super-oleophobicity, excellent oil resistance and outstanding oil/water separation performance with a superior high permeating flux (54,500 L m  h) and rejection (>99.9%) under gravity force, indicating the mesh possesses great potential for treating oily wastewater.
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http://dx.doi.org/10.1016/j.jhazmat.2019.04.009DOI Listing
July 2019

A resource-utilization way of the waste printed circuit boards to prepare silicon carbide nanoparticles and their photocatalytic application.

J Hazard Mater 2019 07 28;373:640-648. Epub 2019 Mar 28.

School of Environmental Science and Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510275, PR China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou, 510275, PR China. Electronic address:

A resource-utilization strategy of the waste PCBs was developed: preparation of high value-added silicon carbide (SiC) nanoparticles using the waste PCBs as both silica and carbon precursors. The preparation process contained three optimized steps: acid wash pretreatment with 3 mol L nitric acid at 60 °C for 96 h, low-temperature pyrolysis at 500 °C to allow the epoxy resin to decompose into carbon, and high-temperature pyrolysis at 1600 °C (in situ carbothermal reduction) to gain pure SiC nanoparticles. The pseudo first-order reaction rate constant (k) of the p-n heterojunction of SiC/TiO towards the photocatalytic degradation of methylene blue was 0.0219 min, 3.42 and 3.98 times that of TiO and no acid washed-SiC/TiO, respectively.
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http://dx.doi.org/10.1016/j.jhazmat.2019.03.115DOI Listing
July 2019

Layer-by-layer self-assembly of polyaniline nanofibers/TiO nanotubes heterojunction thin film for ammonia detection at room temperature.

Nanotechnology 2019 Mar 8;30(13):135501. Epub 2019 Jan 8.

State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266580, Shandong, People's Republic of China. School of Materials Science and Engineering, China University of Petroleum, Qingdao 266580, Shandong, People's Republic of China.

In this paper, for the first time, polyaniline nanofibers/TiO nanotubes (PANI/TiO) heterojunction thin film has been prepared on Pt interdigital electrodes by layer-by-layer self-assembly method and applied in room temperature NH detection. It is found that the optimal self-assembly layer number is three (PANI/TiO-3) compared to one layer (PANI/TiO-1) and five layers (PANI/TiO-5). The PANI/TiO-3 thin film sensor possesses superior response characteristics compared with our other PANI based sensors, including higher response value (336%@5 ppm NH), acceptable response/recovery time (110 s/1 086 [email protected] ppm NH), low detection limit (0.5 ppm), and remarkable selectivity. The enhanced gas sensing performances could be ascribed to the tremendous variation of the carrier concentration caused by the p-n junctions as well as the increased specific surface area and pore volume. This work not only offers a superb strategy to fabricate heterojunction thin film but also accelerates the development of room-temperature operable NH sensors.
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http://dx.doi.org/10.1088/1361-6528/aafc7eDOI Listing
March 2019

Recovery of Cu(II) from aqueous solution by induced crystallization in a long-term operation.

J Environ Sci (China) 2018 Jul 23;69:183-191. Epub 2017 Oct 23.

School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

The feasibility of copper recovery by induced crystallization in a long period (174days) was investigated in a seeded fluidized bed reactor (FBR). The process was divided into 3 periods according to different influent conditions, and the period III was separated into III-a and III-b due to the adjustment of the molar ratio of CO concentration to copper concentration ([C]/[Cu]). The removal efficiency could exceed 95% and the average effluent copper concentration decreased to 3.0mg/L. The mean particle size of seed grains with copper crystals coating on, raised to 0.36mm from initial 0.18mm. During period III-a, the supersaturation exceeded 2.88×10, the removal efficiency decreased to 60%-80% and the particle size dropped to 0.30mm, due to the generation of fines by homogeneous crystallization and seeds breaking. And the morphology of the crystals on the seed grains changed from rod-like to spherical which lead to the particle size decreasing. In period III-b, the supersaturation was modified by adjusting the molar ratio of [C]/[Cu] to 1.2 from 2. The efficiency was back to 95% and the mean particle size grew to 0.36mm at the end of III-b, the crystals coating on the seeds turned back to rod-like products of good stability. This study illustrated that the copper salt crystal could keep on growing on the seed grains for over 150days, the feasibility and controllability of copper recovery by induced crystallization process in FBR were satisfactory, even under the dramatic changes in influent conditions.
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http://dx.doi.org/10.1016/j.jes.2017.10.007DOI Listing
July 2018

Hemolytic reactions in the hemolymph of bivalve Sinonovacula constricta show complement-like activity.

Fish Shellfish Immunol 2018 Aug 1;79:11-17. Epub 2018 May 1.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai 201306, China; Shanghai Engineering Research Center of Aquaculture, Shanghai 201306, China. Electronic address:

The complement-like hemolysis method was used to determine the total complement-like activity of the plasma of Sinonovacula constricta. In this study, the effects of both physical and chemical conditions on complement hemolysis of S. constricta were measured. Physical conditions included proportion (S. constricta plasma: 2% rabbit red blood cells), temperature, time, and incubation, while the chemical factors consisted of Lipopolysaccharide (LPS), Flagellin (FLA), Zymosan, Peptidoglycan (PGN), Phenylmethanesulfonyl fluoride (PMSF), Methylamine, and Poly (I: C). The results showed that LPS, flagellin, Zymosan and PGN could activate complement-like activity of S. constricta plasma and cause hemolysis. PMSF and methylamine inhibited complement-like activity, resulting in the disappearance of hemolysis. Poly (I: C) had no effect on plasma complement-like activity. When the reaction temperature was less than 50 °C, hemolytic activity would increase following an increase in temperature. The ratio of plasma to rabbit blood cells had a great impact on the rate of hemolysis. Additionally, incubation with low speed oscillation could improve the hemolysis rate. It is indicated that the hemolytic reactions in the hemolymph of bivalve S. constricta show complement-like activity. The results contribute to further research on immune function of complement in bivalve.
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http://dx.doi.org/10.1016/j.fsi.2018.04.062DOI Listing
August 2018

Synthesis of nanowire bundle-like WO-WO heterostructures for highly sensitive NH sensor application.

J Hazard Mater 2018 Jul 14;353:290-299. Epub 2018 Apr 14.

State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266580, Shandong, PR China; College of Science, China University of Petroleum, Qingdao 266580, Shandong, PR China. Electronic address:

Heterojunctions are very promising structures due to their hybrid properties, which are usually obtained via a multistep growth process. However, in this paper, WO-WO heterostructures are synthesized via a novel one-step approach by using isopropanol as reaction media and are applied in NH gas detection for the first time. The obtained WO-WO heterostructures with loose nanowire bundle-like morphology show a response value of 23.3 toward 500 ppm NH at 250 °C, which is 5.63 times higher than that of pristine WO. In addition, the WO-WO sensor also exhibits great dynamic response/recovery characteristics (13 s/49 s @ 500 ppm NH), superb selectivity and low detection limit of 460 ppb. The substantial improvement in the response of WO-WO heterostructures toward NH can be explained by the formation of n-WO/n-WO heterojunctions that facilitate the generation of a more extended depletion layer as well as the enhancement of specific surface area and pore volume. Our research results open an easy pathway for facile one-step preparation of heterojunctions with high response and low cost, which can be used for the development of other high-performance gas sensors.
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http://dx.doi.org/10.1016/j.jhazmat.2018.04.020DOI Listing
July 2018

Tuning role and mechanism of paint sludge for characteristics of sewage sludge carbon: Paint sludge as a new macro-pores forming agent.

J Hazard Mater 2018 Feb 7;344:657-668. Epub 2017 Nov 7.

School of Environment Science and Engineering, Sun Yat-Sen(Zhongshan) University, Guangzhou 510275, PR China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou 510275, PR China. Electronic address:

For the first time, paint sludge waste (PS) was used as a pore forming agent in the preparation of sewage sludge derived carbon (SC). The tuning role and mechanism of PS for characteristics of SC were explored. It was found that a sludge carbon (SC) with rich macro-, meso- and micro- porous could be produced by one-step pyrolytic process of sludge in the presence of PS and ZnCl Its surface area could reach as high as 680.5mg as 88.4 times and 4.8 times of sludge carbon without addition of PS and ZnCl (SC) and only addition of ZnCl (SC) respectively. The macro- pores fabricated by PS provided much inner-space for ZnCl to generate meso- and micro- porous, leading to a hierarchical porous structure. SC showed a high adsorption capacity of 685.4mgg for Chrysophenine, which is 1.3 and 1.7 times that of SC and SC respectively. The adsorption difference could be simply attributed to the fact that the great molecules were difficult to enter micro- pores of SC. It was also found that the difference was also dependent on orientation of Chrysophenine, which was related to pH value of solution.
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http://dx.doi.org/10.1016/j.jhazmat.2017.11.012DOI Listing
February 2018

Ultra-sensitive NH sensor based on flower-shaped SnS nanostructures with sub-ppm detection ability.

J Hazard Mater 2018 Jan 25;341:159-167. Epub 2017 Jul 25.

State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266580, Shandong, PR China; College of Science, China University of Petroleum, Qingdao 266580, Shandong, PR China. Electronic address:

Layered metal dichalcogenides (LMDs) semiconducting materials have recently attracted tremendous attention as high performance gas sensors due to unique chemical and physical properties of thin layers. Here, three-dimensional SnS nanoflower structures assembled with thin nanosheets were synthesized via a facile solvothermal process. When applied to detect 100ppm NH at 200°C, the SnS based sensor exhibited high response value of 7.4, short response/recovery time of 40.6s/624s. Moreover, the sensor demonstrated a low detection limit of 0.5ppm NH and superb selectivity to NH against CO, CH, H, ethanol and acetone. The excellent performance is attributed to the unique thin layers assembled flower-like nanoarchitecture, which facilitates both the carrier charge transfer process and the adsorption/desorption reaction. More importantly, it was found that the sensor response enhanced with increasing oxygen content in background and was improved by 3.57 times with oxygen content increasing from 0 to 40%. The increased response is owing to the enhanced binding energies between SnS and NH moleculers. Theoretically, density functional theory was employed to reveal the NH adsorption mechanism in different background oxygen contents, which opens a new horizon for LMD based structures applied in various gas sensing fields.
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http://dx.doi.org/10.1016/j.jhazmat.2017.07.060DOI Listing
January 2018

Enhanced Room Temperature Oxygen Sensing Properties of LaOCl-SnO Hollow Spheres by UV Light Illumination.

ACS Sens 2017 May 16;2(5):679-686. Epub 2017 May 16.

State Key Laboratory of Heavy Oil Processing and ‡College of Science, China University of Petroleum , Qingdao 266580, Shandong P. R. China.

In this paper, a facile and elegant Green Chemistry method for the synthesis of SnO based hollow spheres has been investigated. The influences of doping, crystallite morphology, and operating condition on the O sensing performances of SnO based hollow-sphere sensors were comprehensively studied. It was indicated that, compared with undoped SnO, 10 at. % LaOCl-doped SnO possessed better O sensing characteristics owing to an increase of specific surface area and oxygen vacancy defect caused by LaOCl dopant. More importantly, it was found that O sensing properties of the 10 at. % LaOCl-SnO sensor were significantly improved by ultraviolet light illumination, which was suited for room-temperature O sensing applications. Besides, this sensor also had a better selectivity to O with respect to H, CH, NH, and CO. The remarkable increase of O sensing properties by UV light radiation can be explained in two ways. On one hand, UV light illumination promotes the generation of electron-hole pairs and oxygen adsorption, giving rise to high O response. On the other hand, UV light activates desorption of oxygen adsorbates when exposed to pure N, contributing to rapid response/recovery speed. The results demonstrate a promising approach for room-temperature O detection.
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http://dx.doi.org/10.1021/acssensors.7b00129DOI Listing
May 2017

Ultrahigh broadband photoresponse of SnO nanoparticle thin film/SiO/p-Si heterojunction.

Nanoscale 2017 Jun;9(25):8848-8857

State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Qingdao 266580, Shandong, P. R. China.

The SnO/Si heterojunction possesses a large band offset and it is easy to control the transportation of carriers in the SnO/Si heterojunction to realize high-response broadband detection. Therefore, we investigated the potential of the SnO nanoparticle thin film/SiO/p-Si heterojunction for photodetectors. It is demonstrated that this heterojunction shows a stable, repeatable and broadband photoresponse from 365 nm to 980 nm. Meanwhile, the responsivity of the device approaches a high value in the range of 0.285-0.355 A W with the outstanding detectivity of ∼2.66 × 10 cm H W and excellent sensitivity of ∼1.8 × 10 cm W, and its response and recovery times are extremely short (<0.1 s). This performance makes the device stand out among previously reported oxide or oxide/Si based photodetectors. In fact, the photosensitivity and detectivity of this heterojunction are an order of magnitude higher than that of 2D material based heterojunctions such as (BiTe)/Si and MoS/graphene (photosensitivity of 7.5 × 10 cm W and detectivity of ∼2.5 × 10 cm H W). The excellent device performance is attributed to the large Fermi energy difference between the SnO nanoparticle thin film and Si, SnO nanostructure, oxygen vacancy defects and thin SiO layer. Consequently, practical highly-responsive broadband PDs may be actualized in the future.
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http://dx.doi.org/10.1039/c7nr03437gDOI Listing
June 2017

Activation of peroxymonosulfate by nitrogen-functionalized sludge carbon for efficient degradation of organic pollutants in water.

Bioresour Technol 2017 Oct 19;241:244-251. Epub 2017 May 19.

School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510006, PR China; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou 510006, PR China.

Nitrogen-functionalized sludge carbon (NSC) was prepared by urea-mediated pyrolysis of sewage sludge (SS) and was introduced, for the first time, as a potential metal-free catalyst to activate peroxymonosulfate (PMS) for oxidative removal of organic pollutants in water. The nitrogen functionalization of NSC catalysts significantly affected the chemical micro-environments as well as microstructures (morphology and porosity), improving the PMS activation activity towards removing various pollutants, e.g., acid orange 7, phenol and rhodamine B. On the basis of quenching studies and electron paramagnetic resonance, the formed dominant reactive oxidative species (ROS) in the NSC/PMS system was clarified to be nonradical singlet oxygen, in addition to the typical radical ROSs, sulfate and hydroxyl radicals. The incorporated pyridine N, graphite N and pristine CO in the NSC framework promoted the generation of ROS. This study provided new insights into environmentally friendly resourcing SS and exploiting novel cost-effective metal-free catalyst for PMS activation.
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http://dx.doi.org/10.1016/j.biortech.2017.05.102DOI Listing
October 2017

Performance and Mechanism of Piezo-Catalytic Degradation of 4-Chlorophenol: Finding of Effective Piezo-Dechlorination.

Environ Sci Technol 2017 Jun 11;51(11):6560-6569. Epub 2017 May 11.

School of Environmental Science and Engineering, Guangzhou University , Guangzhou 510006, P. R. China.

Piezo-catalysis was first used to degrade a nondye pollutant, 4-chlorophenol (4-CP). In this process, hydrothermally synthesized tetragonal BaTiO nano/micrometer-sized particles were used as the piezo-catalyst, and the ultrasonic irradiation with low frequency was selected as the vibration energy to cause the deformation of tetragonal BaTiO. It was found that the piezoelectric potential from the deformation could not only successfully degrade 4-chlorophenol but also effectively dechlorinate it at the same time, and five kinds of dechlorinated intermediates, hydroquinone, benzoquinone, phenol, cyclohexanone, and cyclohexanol, were determined. This is the first sample of piezo-dechlorination. Although various active species, including h, e, •H, •OH, •O, O, and HO, were generated in the piezoelectric process, it was confirmed by ESR, scavenger studies, and LC-MS that the degradation and dechlorination were mainly attributed to •OH radicals. These •OH radicals were chiefly derived from the electron reduction of O, partly from the hole oxidation of HO. These results indicated that the piezo-catalysis was an emerging and effective advanced oxidation technology for degradation and dechlorination of organic pollutants.
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http://dx.doi.org/10.1021/acs.est.6b06426DOI Listing
June 2017

An Electrochemical Strategy using Multifunctional Nanoconjugates for Efficient Simultaneous Detection of O157: H7 and O1.

Theranostics 2017 21;7(4):935-944. Epub 2017 Feb 21.

Department of Clinical Laboratory Science, College of Medical Laboratory, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, PR China.

The rapid and accurate quantification of the pathogenic bacteria is extremely critical to decrease the bacterial infections in all areas related to health and safety. We have developed an electrochemical strategy for simultaneous ultrasensitive detection of O157:H7 and O1. This approach was based on the specific immune recognition of different pathogenic bacteria by multifunctional nanoconjugates and subsequent signal amplification. By employing the proposed biosensor, the concentrations of these pathogenic bacteria could be established on a single interface in a single run with improved sensitivity and accuracy. The successful approach of the simultaneous detection and quantification of two bacteria by an electrochemical biosensor demonstrated here could be readily expanded for the estimation of a variety of other pathogenic bacteria, proteins, and nucleotides. Because of their high sensitivity, electrochemical biosensors may represent a new avenue for early diagnosis of diseases.
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http://dx.doi.org/10.7150/thno.17544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381255PMC
October 2017

Coupling template nanocasting and self-activation for fabrication of nanoporous carbon.

Sci Rep 2016 11 30;6:38176. Epub 2016 Nov 30.

Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510275, P. R. China.

Hierarchical nanoporous carbon (NPC) with great surface area and developed pore size distribution has been intently concerned. Herein, we report a facile method coupling template nanocasting and self-activation to fabricate nanoporous carbon with continuous micro, meso and macro pores, in which CaCO acted as template and activation reagent while the flour was the carbon precursor. Effects of mass ratio of CaCO to flour and carbonized temperature on the pore structures of NPC were investigated by nitrogen adsorption-desorption isotherms and SEM analysis. Another kind of carbon was prepared by directly mixed powder CaCO with flour carbonized at 800 °C (NPC-p) to comparatively investigate the pore fabricating mechanism. Results shown that carbonized at 800 °C was favorable to fabricate the continuous macro, meso and micro pores. The resulted NPC in a mass ratio of 1 to 2 had the considerable S and V of 575.4 m/g and 0.704 cm/g, respectively. Only surface activation was observed for NPC-p. Nanocasting of the powder CaCO contributed to fabricate macropores and the CO activation contributed to meso- and micropores. Coupling activation and nanocasting effect due to the decomposition of CaCO template into CO and CaO was ascribed to synthesize the nanoporous carbon.
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http://dx.doi.org/10.1038/srep38176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128880PMC
November 2016

Simultaneous reduction and adsorption for immobilization of uranium from aqueous solution by nano-flake Fe-SC.

J Hazard Mater 2016 Dec 25;320:435-441. Epub 2016 Aug 25.

School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510275, PR China; Guangdong Provincial Key Laboratory of radioactive contamination control and resources, Guangzhou University, Guangzhou, 510275, PR China. Electronic address:

Uranium containing radioactive wastewater is seriously hazardous to the natural environment if it is being discharged directly. Herein, nano-flake like Fe loaded sludge carbon (Fe-SC) is synthesized by carbothermal process from Fe-rich sludge waste and applied in the immobilization of uranium in aqueous. Batch isotherm and kinetic adsorption experiments are adopted to investigate the adsorption behavior of Fe-SC to uranium in aqueous. XPS analyses were conducted to evaluate the immobilized mechanism. It was found that the carbonized temperature played significant role in the characteristics and immobilization ability of the resulted Fe-SC. The Fe-SC-800 carbonized at 800°C takes more advantageous ability in immobilization of uranium from aqueous than the commercial available AC and powder zero valent iron. The adsorption behavior could be fitted well with the Langmuir isotherm adsorption model and pseudo-second order model. The equilibrium adsorption amount and rate for Fe-SC-800 is high to 148.99mgg and 0.015gmgmin, respectively. Both reductive precipitation and physical adsorption are the main mechanisms of immobilization of uranium from aqueous by Fe-SC-800.
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http://dx.doi.org/10.1016/j.jhazmat.2016.08.060DOI Listing
December 2016

Conversion of Fe-rich waste sludge into nano-flake Fe-SC hybrid Fenton-like catalyst for degradation of AOII.

Environ Pollut 2016 Sep 16;216:568-574. Epub 2016 Jun 16.

School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510275, PR China; Guangdong Provincial Key Laboratory of Radioactive Contamination Control and Resources, Guangzhou University, Guangzhou, 510275, PR China. Electronic address:

Permanently increasing in the amount of sludge resulted in the serious environment burden. This work reports a novel carbothermal process for converting the Fe-rich waste sludge into cleaner nano-flake Fenton-like catalyst to relieve the crisis. The transformation of Fe species at different carbothermal temperature was evaluated by XRD analysis. SEM and XPS analyses were involved to characterize the morphology and chemical bonds of the catalysts. Results shown that the resulted catalyst carbonized at 800 °C (Fe-SC-800) was composed of Fe(0) and Fe3O4, performing nano-flake-like structure. The Fe-SC-800 has the highest catalytic activity in degradation of AOII in C0 = 200 mg/L. The efficiency achieves at 98% within 30 min at neutral pH, which is ascribed to the hydroxyl radical oxidation. Moreover, no iron is leached and the Fe-SC-800 could be recycled for three times at least. Thus, the Fe rich sludge could be reutilized as a valuable source for eco-friendly catalyst production, constituting an ecological way to manage these sludge wastes and eliminate the sludge and organic pollution to environment.
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http://dx.doi.org/10.1016/j.envpol.2016.06.012DOI Listing
September 2016

Electrospun TiO2/C Nanofibers As a High-Capacity and Cycle-Stable Anode for Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2016 Jul 24;8(26):16684-9. Epub 2016 Jun 24.

College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, China.

Nanosized TiO2 is now actively developed as a low-cost and potentially high capacity anode material of Na-ion batteries, but its poor capacity utilization and insufficient cyclability remains an obstacle for battery applications. To overcome these drawbacks, we synthesized electrospun TiO2/C nanofibers, where anatase TiO2 nanocrystals with a diameter of ∼12 nm were densely embedded in the conductive carbon fibers, thus preventing them from aggregating and attacking by electrolyte. Due to its abundant active surfaces of well-dispersed TiO2 nanocrytals and high electronic conductivity of the carbon matrix, the TiO2/C anode shows a high redox capacity of ∼302.4 mA h g(-1) and a high-rate capability of 164.9 mAh g(-1) at a very high current of 2000 mA g(-1). More significantly, this TiO2/C anode can be cycled with nearly 100% capacity retention over 1000 cycles, showing a sufficiently long cycle life for battery applications. The nanofibrous architecture of the TiO2/C composite and its superior electrochemical performance may provide new insights for development of better host materials for practical Na-ion batteries.
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http://dx.doi.org/10.1021/acsami.6b03757DOI Listing
July 2016

Nanogold-functionalized g-C3N4 nanohybrids for sensitive impedimetric immunoassay of prostate-specific antigen using enzymatic biocatalytic precipitation.

Biosens Bioelectron 2016 Nov 6;85:212-219. Epub 2016 May 6.

Department of Dermatology, Southwest Hospital, The Third Military Medical University, Gaotanyan Street, Chongqing 400038, PR China. Electronic address:

This work reports on a new impedimetric immunosensing strategy for sensitive detection of prostate-specific antigen (PSA) in biological fluids. The assay was carried out on monoclonal anti-PSA capture antibody-modified glassy carbon electrode with a sandwich-type detection format. Gold nanoparticles-decorated g-C3N4 nanosheets (AuNP/g-C3N4), synthesized by the wet-chemistry method, were utilized for the labeling of polyclonal anti-PSA detection antibody and horseradish peroxidase (HRP). Upon target PSA introduction, the sandwiched immunocomplex could be formed between capture antibody and detection antibody. Followed by the AuNP/g-C3N4, the labeled HRP could catalyze 4-choloro-1-naphthol into benzo-4-chlorohexadienone. The as-generated insoluble product was coated on the electrode surface, thus increasing the Faradaic impedance of Fe(CN)6(4-/3)(-) indicator between the solution and the base electrode. Under the optimal conditions, the impedance increased with the increasing target PSA in the sample, and exhibited a wide linear range from 10pgmL(-1) and 30ngmL(-1) with a detection limit of 5.2pgmL(-1). A repeatability and intermediate precision of <14% was accomplished. The specificity and method accuracy in comparison with commercial PSA ELISA kit for analysis of human serum specimens were relatively satisfactory.
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http://dx.doi.org/10.1016/j.bios.2016.04.102DOI Listing
November 2016

Highly selective enrichment of baicalin in rat plasma by boronic acid-functionalized core-shell magnetic microspheres: Validation and application to a pharmacokinetic study.

Talanta 2016 Jan 21;147:501-9. Epub 2015 Oct 21.

Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, No. 220, Handan Road, Shanghai 200433, China. Electronic address:

To the best of our knowledge, this study is the first to successfully apply a novel, highly selective enrichment technique based on boronic acid-functionalized core-shell magnetic microspheres ([email protected]@mSiO2) with a large surface area and uniform pore size, to determine the baicalin concentration in rat plasma by HPLC. By taking advantage of the special interaction between boronic acid and baicalin under alkaline conditions, as well as the microspheres' size exclusion ability, baicalin was selectively extracted from protein-rich biosamples, such as plasma, without any other pretreatment procedure except for a 10-min vortexing step. [email protected]@mSiO2 microsphere-adsorbed baicalin was straightforwardly and rapidly isolated from the matrix using a magnet. Baicalin was subsequently eluted from the microspheres under acidic conditions for 2min for further HPLC analysis. The extraction conditions, such as the amount of microspheres added, adsorption time, adsorption pH, and elution time and pH, were also determined. Furthermore, method validation, including the linear range, detection limit, precision, accuracy, and recovery, were determined. This newly developed method based on [email protected]@mSiO2 microspheres is a simple, accurate, selective, and green analytical preparatory technique for analyzing baicalin in rat plasma. This study will be further novel research on the analysis of complex plasma samples and the pharmacokinetics of drugs similar to baicalin.
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http://dx.doi.org/10.1016/j.talanta.2015.10.042DOI Listing
January 2016

[Primary cutaneous diffuse large B-cell lymphoma, leg type: a study of clinicopathology, immunophenotype and gene rearrangement].

Zhonghua Bing Li Xue Za Zhi 2015 Feb;44(2):100-5

E-mail: lkzwl

Objective: To study the clinicopathologic features, immunophenotype and gene rearrangement of primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL).

Methods: Seven cases of PCLBCL were enrolled into the study. Clinicopathologic analysis, immunohistochemical staining and gene rearrangement for IgH and Igκ were undertaken in the study.

Results: All the seven cases were male, and the median age was 72 years. Patients usually presented with multiple purple tumors, nodules, papules and infiltrative plaques. Two patients had a history of leg injury before onset, and one had mosquito bites. Histologically, the tumor involved the dermis and subcutis with dense and diffuse infiltrative pattern composing of centroblasts and/or immunoblasts. Immunohistochemical staining showed that seven cases (7/7) expressed CD20, six (6/6) expressed bcl-2, four (4/4) expressed MUM-1, four (4/5) expressed CD79a, four (4/5) expressed PAX-5 and four (4/6) expressed bcl-6, respectively. All cases did not express CD3ε, CD45RO, CD10 and CD30. IgH gene rearranged bands were detected in three (3/6) cases and Igκ was detected in one (1/5) case. Six of the seven cases died and the remaining patient, who was 44-year-old, was alive after 22 months of follow-up.

Conclusions: PCLBCL is rare, predominantly affects elderly male patients. PCLBCL has poor prognosis and high mortality, but younger patients seem to have better prognosis. Some cases had a history of trauma or mosquito bites. The relationship between the history and the onset of PCLBCL needs further evaluation.
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February 2015

Designed synthesis of aptamer-immobilized magnetic mesoporous silica/Au nanocomposites for highly selective enrichment and detection of insulin.

ACS Appl Mater Interfaces 2015 Apr 17;7(16):8451-6. Epub 2015 Apr 17.

Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.

We designed and synthesized aptamer-immobilized magnetic mesoporous silica/Au nanocomposites (MMANs) for highly selective detection of unlabeled insulin in complex biological media using MALDI-TOF MS. The aptamer was easily anchored onto the gold nanoparticles in the mesochannels of MMANs with high capacity for highly efficient and specific enrichment of insulin. With the benefit from the size-exclusion effect of the mesoporous silica shell with a narrow pore size distribution (∼2.9 nm), insulin could be selectively detected despite interference from seven untargeted proteins with different size dimensions. This method exhibited an excellent response for insulin in the range 2-1000 ng mL(-1). Moreover, good recoveries in the detection of insulin in 20-fold diluted human serum were achieved. We anticipate that this novel method could be extended to other biomarkers of interest and potentially applied in disease diagnostics.
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http://dx.doi.org/10.1021/acsami.5b00515DOI Listing
April 2015

Effective solidification/stabilisation of mercury-contaminated wastes using zeolites and chemically bonded phosphate ceramics.

Waste Manag Res 2015 Feb 7;33(2):183-90. Epub 2015 Jan 7.

Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, People's Republic of China

In this study, two kinds of zeolites materials (natural zeolite and thiol-functionalised zeolite) were added to the chemically bonded phosphate ceramic processes to treat mercury-contaminated wastes. Strong promotion effects of zeolites (natural zeolite and thiol-functionalised zeolite) on the stability of mercury in the wastes were obtained and these technologies showed promising advantages toward the traditional Portland cement process, i.e. using Portland cement as a solidification agent and natural or thiol-functionalised zeolite as a stabilisation agent. Not only is a high stabilisation efficiency (lowered the Toxicity Characteristic Leaching Procedure Hg by above 10%) obtained, but also a lower dosage of solidification (for thiol-functionalised zeolite as stabilisation agent, 0.5 g g(-1) and 0.7 g g(-1) for chemically bonded phosphate ceramic and Portland cement, respectively) and stabilisation agents (for natural zeolite as stabilisation agent, 0.35 g g(-1) and 0.4 g g(-1) for chemically bonded phosphate ceramic and Portland cement, respectively) were used compared with the Portland cement process. Treated by thiol-functionalised zeolite and chemically bonded phosphate ceramic under optimum parameters, the waste containing 1500 mg Hg kg(-1) passed the Toxicity Characteristic Leaching Procedure test. Moreover, stabilisation/solidification technology using natural zeolite and chemically bonded phosphate ceramic also passed the Toxicity Characteristic Leaching Procedure test (the mercury waste containing 625 mg Hg kg(-1)). Moreover, the presence of chloride and phosphate did not have a negative effect on the chemically bonded phosphate ceramic/thiol-functionalised zeolite treatment process; thus, showing potential for future application in treatment of 'difficult-to-manage' mercury-contaminated wastes or landfill disposal with high phosphate and chloride content.
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http://dx.doi.org/10.1177/0734242X14563376DOI Listing
February 2015

Development of aptamer-conjugated magnetic graphene/gold nanoparticle hybrid nanocomposites for specific enrichment and rapid analysis of thrombin by MALDI-TOF MS.

Talanta 2014 Nov 6;129:282-9. Epub 2014 Jun 6.

Department of Chemistry and Institutes of Biomedical Science, Fudan University, Shanghai 200433, China.

Simple, rapid and sensitive analysis of thrombin (a tumor biomarker) in complex samples is quite clinical relevant and essential for the development of disease diagnosis and pharmacotherapy. Herein, we developed a novel method based on aptamer-conjugated magnetic graphene/gold nanoparticles nanocomposites ([email protected]) for specific enrichment and rapid analysis of thrombin in biological samples using MALDI-TOF-MS. At first, gold nanoparticles were compactly deposited on PDDA functionalized magnetic graphene through electrostatic interaction. Afterwards, aptamer was easily conjugated to gold nanoparticles via Au-S bond formation. The as-made aptamer-conjugated nanocomposites took advantage of the magnetism of magnetic graphene, the high affinity and specificity of aptamer, facilitating a high-efficient separation and enrichment of thrombin. More importantly, due to the large surface area of the hybrid substrate, the average coverage density of aptamer achieved 0.34 nmol/mg, which enhanced the thrombin binding capacity and the recovery of thrombin in real samples. In turn, the enriched thrombin attributed to the sensitive output of MALDI-TOF mass spectrometry signal, 0.085 ng μL(-1) (2.36 nM) thrombin could be detected. This proposed method has a relatively wide linear relation ranging from 0.1 ng μL(-1) to 10 ng μL(-1), and satisfactory specificity. The proposed high-throughput method based on MALDI-TOF MS is expected to the application in the disease biomarker detection and clinical diagnosis.
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http://dx.doi.org/10.1016/j.talanta.2014.05.045DOI Listing
November 2014

Accelerated start-up of moving bed biofilm reactor by using a novel suspended carrier with porous surface.

Bioprocess Biosyst Eng 2015 Feb 9;38(2):273-85. Epub 2014 Aug 9.

School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China,

A novel suspended carrier with porous surface was firstly prepared by coating a sponge on the inside and outside of a hard polyethylene ring. Herein the effects of the sponge thickness (0, 2, 4, 6 mm) and pore size (17, 45, 85 pores per inch, ppi) on the performance of the start-up stage in moving bed biofilm reactor (MBBR) were investigated. The results indicated that the home-made carrier with the sponge thickness of 4 mm and the pore size of 45 ppi, defined as SC4-45, showed the best performance, which obtained high biomass concentration of 2,136.6 mg/L, oxygen uptake rate for COD of 150.1 mg O2/h and oxygen uptake rate for NH4(+)-N of 17.4 mg O2/h. The DGGE profiles of the biofilms obtained in SC4-45 and a commercial carrier showed a similar community as the Dice similarity coefficients between two samples was 0.72. Furthermore, 16S rRNA gene sequence analysis reveals dominance of Sphaerotilus sp. and Aeromonas sp. in the community of both samples. Moreover, for the MBBR based on SC4-45, COD and NH4(+)-N removal rates reached 99.5 ± 1.1 and 93.6 ± 2.3 % at the end of the start-up stage, much higher than those of the commercial carrier, 74.9 ± 2.7 and 40.0 ± 1.8 %, respectively. These indicated the novel carrier obtained a quick start-up.
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http://dx.doi.org/10.1007/s00449-014-1266-6DOI Listing
February 2015

Utilization of solar energy in sewage sludge composting: fertilizer effect and application.

Waste Manag 2014 Nov 27;34(11):2014-21. Epub 2014 Jul 27.

School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Three reactors, ordinary, greenhouse, and solar, were constructed and tested to compare their impacts on the composting of municipal sewage sludge. Greenhouse and solar reactors were designed to evaluate the use of solar energy in sludge composting, including their effects on temperature and compost quality. After 40 days of composting, it was found that the solar reactor could provide more stable heat for the composting process. The average temperature of the solar reactor was higher than that of the other two systems, and only the solar reactor could maintain the temperature above 55°C for more than 3 days. Composting with the solar reactor resulted in 31.3% decrease in the total organic carbon, increased the germination index to 91%, decreased the total nitrogen loss, and produced a good effect on pot experiments.
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http://dx.doi.org/10.1016/j.wasman.2014.06.029DOI Listing
November 2014

Catalytic wet air oxidation of 2-chlorophenol over sewage sludge-derived carbon-based catalysts.

J Hazard Mater 2014 Jul 16;276:88-96. Epub 2014 May 16.

Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), CNRS - Université Claude Bernard Lyon 1, 2 Avenue Albert Einstein, 69626 Villeurbanne Cedex, France. Electronic address:

A sewage sludge derived carbon-supported iron oxide catalyst (FeSC) was prepared and used in the Catalytic Wet Air Oxidation (CWAO) of 2-chlorophenol (2-CP). The catalysts were characterized in terms of elemental composition, surface area, pHPZC, XRD and SEM. The performances of the FeSC catalyst in the CWAO of 2-CP was assessed in a batch reactor operated at 120°C under 0.9MPa oxygen partial pressure. Complete decomposition of 2-CP was achieved within 5h and 90% Total Organic Carbon (TOC) was removed after 24h of reaction. Quite a straight correlation was observed between the 2-CP conversion, the amount of iron leached in solution and the pH of the reaction mixture at a given reaction time, indicating a strong predominance of the homogeneous catalysis contribution. The iron leaching could be efficiently prevented when the pH of the solution was maintained at values higher than 4.5, while the catalytic activity was only slightly reduced. Upon four successive batch CWAO experiments, using the same FeSC catalyst recovered by filtration after pH adjustment, only a very minor catalyst deactivation was observed. Finally, based on all the identified intermediates, a simplified reaction pathway was proposed for the CWAO of 2-CP over the FeSC catalyst.
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http://dx.doi.org/10.1016/j.jhazmat.2014.05.024DOI Listing
July 2014
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