Publications by authors named "Ya Liu"

629 Publications

A Novel Graphene Quantum Dot-Based mRNA Delivery Platform.

ChemistryOpen 2021 Apr 7. Epub 2021 Apr 7.

Department of Microtechnology and Nanoscience, Chalmers University of Technology, 9 Kemivägen, Gothenborg, 412 96, Sweden.

During the last decades, there has been growing interest in using therapeutic messager RNA (mRNA) together with drug delivery systems. Naked, unformulated mRNA is, however, unable to cross the cell membrane and is susceptible to degradation. Here we use graphene quantum dots (GQDs) functionalized with polyethyleneimine (PEI) as a novel mRNA delivery system. Our results show that these modified GQDs can be used to deliver intact and functional mRNA to Huh-7 hepatocarcinoma cells at low doses and, that the GQDs are not toxic, although cellular toxicity is a problem for these first-generation modified particles. Functionalized GQDs represent a potentially interesting delivery system that is easy to manufacture, stable and effective.
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http://dx.doi.org/10.1002/open.202000200DOI Listing
April 2021

Mediastinum-type lung cancer on 68Ga-FAPI PET/CT with cardiac insufficiency as the first symptom.

J Nucl Cardiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No 15 TaiPing St, Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

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http://dx.doi.org/10.1007/s12350-021-02601-1DOI Listing
April 2021

Closed-Surface Multifunctional Antireflective Coating Made from SiO with TiO Nanocomposites.

Materials (Basel) 2021 Mar 11;14(6). Epub 2021 Mar 11.

Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China.

An SiO-TiO closed-surface antireflective coating was fabricated by the one-dipping method. TiO nanoparticles were mixed with a nanocomposited silica sol, which was composed of acid-catalyzed nanosilica networks and silica hollow nanospheres (HNs). The microstructure of the sol-gel was characterized by transmission electron microscopy. The silica HNs were approximately 40-50 nm in diameter with a shell thickness of approximately 8-10 nm. The branched-chain structure resulting from acidic hydrolysis grew on these silica HNs, and TiO was distributed inside this network. The surface morphology of the coating was measured by field emission scanning electron microscopy and atomic force microscopy. After optimization, transmittance of up to 94.03% was obtained on photovoltaic (PV) glass with a single side coated by this antireflective coating, whose refractive index was around 1.30. The short-circuit current gain of PV module was around 2.14-2.32%, as shown by the current-voltage (IV) curve measurements and external quantum efficiency (EQE) tests. This thin film also exhibited high photocatalytic activity. Due to the lack of voids on its surface, the antireflective coating in this study possessed excellent long-term reliability and robustness in both high-moisture and high-temperature environments. Combined with its self-cleaning function, this antireflective coating has great potential to be implemented in windows and photovoltaic modules.
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http://dx.doi.org/10.3390/ma14061367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7998428PMC
March 2021

Predictors of testicular sperm retrieval in patients with non-obstructive azoospermia: a review.

J Int Med Res 2021 Apr;49(4):3000605211002703

Department of Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Azoospermia is divided into two categories of obstructive azoospermia and non-obstructive azoospermia. Before 1995, couples with a male partner diagnosed with non-obstructive azoospermia had to choose sperm donation or adoption to have a child. Currently, testicular sperm aspiration or micro-dissection testicular sperm extraction combined with intracytoplasmic sperm injection allows patients with non-obstructive azoospermia to have biological offspring. The sperm retrieval rate is significantly higher in micro-dissection testicular sperm extraction compared with testicular sperm aspiration. Additionally, micro-dissection testicular sperm extraction has the advantages of minimal invasion, safety, limited disruption of testicular function, a low risk of postoperative intratesticular bleeding, and low serum testosterone concentrations. Failed micro-dissection testicular sperm extraction has significant emotional and financial implications on the involved couples. Testicular sperm aspiration and micro-dissection testicular sperm extraction have the possibility of failure. Therefore, predicting the sperm retrieval rate before surgery is important. This narrative review summarizes the existing data on testicular sperm aspiration and micro-dissection testicular sperm extraction to identify the possible factor(s) that can predict the presence of sperm to guide clinical practice. The predictors of surgical sperm retrieval in patients with non-obstructive azoospermia have been widely studied, but there is no consensus.
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http://dx.doi.org/10.1177/03000605211002703DOI Listing
April 2021

Generic and Flexible Unmanned Sailboat for Innovative Education and World Robotic Sailing Championship.

Front Robot AI 2021 11;8:630081. Epub 2021 Mar 11.

School of Naval Architecture and Ocean Engineering, Huazhong University of Science and Technology, Wuhan, China.

Over the past two decades, scholars developed various unmanned sailboat platforms, but most of them have specialized designs and controllers. Whereas these robotic sailboats have good performance with open-source designs, it is actually hard for interested researchers or fans to follow and make their own sailboats with these open-source designs. Thus, in this paper, a generic and flexible unmanned sailboat platform with easy access to the hardware and software architectures is designed and tested. The commonly used 1-m class RC racing sailboat was employed to install Pixhawk V2.4.8, Arduino Mega 2,560, GPS module M8N, custom-designed wind direction sensor, and wireless 433 Mhz telegram. The widely used open-source hardware modules were selected to keep reliable and low-cost hardware setup to emphasize the generality and feasibility of the unmanned sailboat platform. In software architecture, the Pixhawk V2.4.8 provided reliable states' feedback. The Arduino Mega 2,560 received estimated states from Pixhawk V2.4.8 and the wind vane sensor, and then controlled servo actuators of rudder and sail using simplified algorithms. Due to the complexity of introducing robot operating system and its packages, we designed a generic but real-time software architecture just using Arduino Mega 2,560. A suitable line-of-sight guidance strategy and PID-based controllers were used to let the autonomous sailboat sail at user-defined waypoints. Field tests validated the sailing performance in facing WRSC challenges. Results of fleet race, station keeping, and area scanning proved that our design and algorithms could control the 1-m class RC sailboat with acceptable accuracy. The proposed design and algorithms contributed to developing educational, low-cost, micro class autonomous sailboats with accessible, generic, and flexible hardware and software. Besides, our sailboat platform also facilitates readers to develop similar sailboats with more focus on their missions.
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http://dx.doi.org/10.3389/frobt.2021.630081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990777PMC
March 2021

Mussel-inspired adhesive and polypeptide-based antibacterial thermo-sensitive hydroxybutyl chitosan hydrogel as BMSCs 3D culture matrix for wound healing.

Carbohydr Polym 2021 Jun 1;261:117878. Epub 2021 Mar 1.

College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR China. Electronic address:

Hydrogels have gained great attentions as wound dressing. Binding to the tissue and preventing wound infection were the basic requirements for an "ideal dressing". We employed l-DOPA and ε-Poly-l-lysine to modify thermo-sensitive hydroxybutyl chitosan (HBC) to obtain (l-DOPA) - (ε-Poly-l-lysine)-HBC hydrogels (eLHBC). The eLHBC exhibited an almost 1.5 fold (P < 0.01) increase in wet adhesion strength compared to HBC. Upon the introduction of ε-Poly-l-lysine, eLHBC presented inherent antimicrobial property and prevented wound infection and inflammation response. Bone marrow mesenchymal stem cells (BMSCs) encapsulated in the eLHBC (BMSCs ⊂ eLHBC) could secret cytokins and growth factors via paracrine and promote the migration of fibroblast cells. BMSCs ⊂ eLHBC enhanced the complete skin-thickness wound healing via promoting collagen deposition and inhibiting infection and inflammation in vivo with wound closure rate being above 99 % after 15 days. The bioinspired, tissue-adhesive eLHBC could serve as advanced wound dressings for facilitating tissue repair and regeneration.
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http://dx.doi.org/10.1016/j.carbpol.2021.117878DOI Listing
June 2021

Facile indium recovery from waste liquid crystal displays: Chloride-facilitated indium electroreduction and stepwise Cu/MoO and indium electrodeposition.

J Hazard Mater 2021 Mar 12;415:125599. Epub 2021 Mar 12.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, People's Republic of China. Electronic address:

With a huge amount of waste liquid crystal displays (LCDs) generated annually, their proper recycling raises continuous concern to realize pollution control (heavy metal and liquid crystal) and resource recovery (indium). However, due to their multi-metal feature, traditional hydrometallurgy lacks of sufficient selectivity, which makes the recycling route lengthy, costly, and generate more waste. Electrodeposition acts as a promising technique for selective metal extraction from multi-metal system due to its high selectivity and electron as clean reagent. To fully develop its application in metal recovery, stepwise Cu/MoO and In electrodeposition from In-Cu-Mo-Fe waste LCD leachate is explored in depth. Electrochemical behavior analysis shows Cu and MoO can be first electrodeposited for their higher electroreduction potential. Cl plays a key role in accelerating indium electroreduction kinetics, which largely shortens the extraction time without the sacrifice of current efficiency. This accelerating effect is attributed to the increased concentration of electroactive species or collision frequency. Under optimized condition, 99.41% of indium (> 99% purity) can be electrodeposited within 13 h with high current efficiency. This study provides a cleaner approach for waste LCDs recycling and gives implications for the potential application of electrochemical technique in e-waste recycling.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125599DOI Listing
March 2021

Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer (Review).

Oncol Rep 2021 May 24;45(5). Epub 2021 Mar 24.

School of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China.

Hydrogen sulfide (HS), the third gas signal molecule, is associated with the modulation of various physiological and pathological processes. Recent studies have reevealed that endogenous HS may promote proliferation, induce angiogenesis and inhibit apoptosis, thereby stimulating oncogenesis. Conversely, decreased endogenous HS release suppresses growth of various tumors including breast cancer. This observation suggests an alternative tumor therapy strategy by inhibiting HS‑producing enzymes to reduce the release of endogenous HS. Breast cancer is the most common type of cancer in women. Due to the lack of approved targeted therapy, its recurrence and metastasis still affect its clinical treatment. In recent years, significant progress has been made in the control of breast cancer by using inhibitors on HS‑producing enzymes. This review summarized the roles of endogenous HS‑producing enzymes in breast cancer and the effects of the enzyme inhibitors on anticancer and anti‑metastasis, with the aim of providing new insights for the treatment of breast cancer.
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http://dx.doi.org/10.3892/or.2021.8019DOI Listing
May 2021

Immunotherapy-Associated Pancreatic Adverse Events: Current Understanding of Their Mechanism, Diagnosis, and Management.

Front Oncol 2021 25;11:627612. Epub 2021 Feb 25.

Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Immune checkpoint inhibitors (ICIs) such as anti-programmed death-1 (PD-1) and its ligand PD-L1 and anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibodies, are involved in T cell-mediated immune response augmentation and promote anti-tumor immunity. Cancer patients treated with combination of immunotherapy, chemotherapy, radiotherapy, and targeted therapy exhibit superior clinical outcomes and tolerance compared with patients treated with monotherapies. However, immutherapy is associated with several concomitant immune-related adverse events (irAEs). For instance, IrAEs interferes with function of gastrointestinal tract, endocrine, dermatological, nervous system and musculoskeletal systems. ICIs-associated pancreatic injury might causes decrease in endocrine and exocrine pancreatic function, resulting in metabolic and nutritional disorders. Clinicians who administer immune checkpoint inhibitors to cancer patients are diagnosed with hyperglycemia, abdominal pain and steatorrhea. Currently, the precise mechanism of ICIs-associated pancreatic injury has not been fully explored. This paper summarizes incidence, diagnosis, clinical characteristics, potential mechanisms, and treatment management patterns of ICIs-associated pancreatic AEs based on previous studies. In addition, possible management approaches of these adverse effects are presented in this paper. in the findings summarized in this paper lay a basis for management of ICIs-associated pancreatic AEs and expanding future immunotherapy applications.
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http://dx.doi.org/10.3389/fonc.2021.627612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959713PMC
February 2021

miR-130a-3p regulates steroid hormone synthesis in goat ovarian granulosa cells by targeting the PMEPA1 gene.

Theriogenology 2021 Apr 19;165:92-98. Epub 2021 Feb 19.

College of Animal Science and Technology, Anhui Agricultural University, Anhui Hefei, 230036, China; Local Animal Genetic Resources Conservation and Biobreeding Laboratory of Anhui Province, Anhui Hefei, 230036, China. Electronic address:

MicroRNAs (miRNAs) are key epigenomic regulators of proliferation, differentiation, and secretion in cells involved in follicular development. We here studied the functional role of one such molecule, miR-130a-3p, in goat ovarian granulosa cells (GCs). High expression of this miRNA was evident in goat GCs by fluorescence in situ hybridization and suppressed estradiol and progesterone secretion from these cells, as determined by ELISA. miR-130a-3p was predicted to have a binding site for the 3' UTR of the prostate transmembrane protein androgen induced 1 gene (PMEPA1), and this was verified by a dual-luciferase reporter assay. PMEPA1 mRNA and protein expression were both found to be regulated by miR-130a-3p in GCs. Moreover, the overexpression or knockdown of PMEPA1 enhanced or suppressed estradiol and progesterone secretion from these cells, respectively. Furthermore, the secretion of estradiol and progesterone did not change significantly after the offsetting of PMEPA1 overexpression in GCs by miR-130a-3p. In summary, our present data indicate that miR-130a-3p inhibits the secretion of estradiol and progesterone in GCs by targeting PMEPA1. Our study thus provides seminal data and important new insights into the regulation of reproductive mechanisms in the nanny goat and other female mammals.
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http://dx.doi.org/10.1016/j.theriogenology.2021.02.012DOI Listing
April 2021

Hypoxia-modulatory nanomaterials to relieve tumor hypoxic microenvironment and enhance immunotherapy: Where do we stand?

Acta Biomater 2021 Feb 24. Epub 2021 Feb 24.

College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, PR China. Electronic address:

The past several years have witnessed the blooming of emerging immunotherapy, as well as their therapeutic potential in remodeling the immune system. Nevertheless, with the development of biological mechanisms in oncology, it has been demonstrated that hypoxic tumor microenvironment (TME) seriously impairs the therapeutic outcomes of immunotherapy. Hypoxia, caused by Warburg effect and insufficient oxygen delivery, has been considered as a primary construction element of TME and drawn tremendous attention in cancer therapy. Multiple hypoxia-modulatory theranostic agents have been facing many obstacles and challenges while offering initial therapeutic effect. Inspired by versatile nanomaterials, great efforts have been devoted to design hypoxia-based nanoplatforms to preserve drug activity, reduce systemic toxicity, provide adequate oxygenation, and eventually ameliorate hypoxic-tumor management. Besides these, recently, some curative and innovative hypoxia-related nanoplatforms have been applied in synergistic immunotherapy, especially in combination with immune checkpoint blockade (ICB), immunomodulatory therapeutics, cancer vaccine therapy and immunogenic cell death (ICD) effect. Herein, the paramount impact of hypoxia on tumor immune escape was initially described and discussed, followed by a comprehensive overview on the design tactics of multimodal nanoplatforms based on hypoxia-enabled theranostic agents. A variety of nanocarriers for relieving tumor hypoxic microenvironment were also summarized. On this basis, we presented the latest progress in the use of hypoxia-modulatory nanomaterials for synergistic immunotherapy and highlighted current challenges and plausible promises in this area in the near future. STATEMENT OF SIGNIFICANCE: Cancer immunotherapy, emerging as a novel treatment to eradicate malignant tumors, has achieved a measure of success in clinical popularity and transition. However, over the last decades, hypoxia-induced tumor immune escape has attracted enormous attention in cancer treatment. Limitations of free targeting agents have paved the path for the development of multiple nanomaterials with the hope of boosting immunotherapy. In this review, the innovative design tactics and multifunctional nanocarriers for hypoxia alleviation are summarized, and the smart nanomaterial-assisted hypoxia-modulatory therapeutics for synergistic immunotherapy and versatile biomedical applications are especially highlighted. In addition, the challenges and prospects of clinical transformation are further discussed.
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http://dx.doi.org/10.1016/j.actbio.2021.02.030DOI Listing
February 2021

Exploration of SQC Formula Effect on Type 2 Diabetes Mellitus by Whole Transcriptome Profile in Rats.

Endocr Metab Immune Disord Drug Targets 2021 Feb 25. Epub 2021 Feb 25.

Endocrinology Department, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075. China.

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that has turned up as dimensions of the pandemic all over the world. In China, some traditional Chinese herbal formulas have enjoyed a high reputation in T2DM treatment for centuries.

Methods: In this study, ShenQi compound (SQC) is proposed, a formula has been performed on T2DM clinical therapeutics in China for many years. The efficacy of SQC in diabetic rat model by measuring food and water intake and examining islet microcirculatory index involves islets microvessel quantity and density, islets size, pancreatic microvascular wall thickness is evaluated. Meanwhile, gene microarray experiments were performed to explore the molecular mechanism of SQC treatment. In addition, a western medicine, metformin was employed as a comparison.

Results: The results indicated that SQC could effectively improve polydipsia, polyphagia and weight loss caused by diabetes as well as pancreatic tissue damage and vascular injury for T2DM. Meanwhile, the gene microarray experiments indicated that SQC may improve the T2DM through affecting the biological functions related to detection of chemical stimulus involved in sensory perception of smell, G-protein coupled receptor signaling pathway, cytoplasmic translation. In addition, SQC presented curative effect by regulated function associated with translation, while metformin presented curative effect by regulated function associated coagulation.

Conclusion: SQC is an effective therapeutic drug on T2DM, and present curative effect by regulated function associated with translation.
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http://dx.doi.org/10.2174/1871530321666210225125141DOI Listing
February 2021

Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in .

Appl Environ Microbiol 2021 Feb 19. Epub 2021 Feb 19.

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237, P. R. China

Bacterial proline-alanine-alanine-arginine (PAAR) proteins are located at the top of the type VI secretion system (T6SS) nanomachine and carry and deliver effectors into neighboring cells. Many PAAR proteins are fused with a variable C-terminal extended domain (CTD). Here, we report that two genes ( and ) located in two homologous operons are involved in different ecological functions of inhibited the growth of plant pathogenic fungi, while was associated with the colony-merger incompatibility of cells. These two PAAR-CTD proteins were both toxic to cells, while MXAN_RS08765, rather than MXAN_RS36995, was also toxic to cells. Their downstream adjacent genes, and , protected against the toxicities. The MXAN_RS36995 protein was demonstrated to have nuclease activity, and the activity was inhibited by the presence of MXAN_RS24590. Our results highlight that the PAAR proteins diversify the CTDs to play divergent roles in The type VI secretion system (T6SS) is a bacterial cell contact-dependent weapon capable of delivering protein effectors into neighboring cells. The PAAR protein is located at the top of the nanomachine and carries an effector for delivery. Many PAAR proteins are extended with a diverse C-terminal sequence with an unknown structure and function. Here, we report two genes located in two homologous operons involved in different ecological functions of : one has antifungal activity, and the other is associated with the self-identification phenotype. The PAAR-CTD proteins and the proteins encoded by their downstream genes form two toxin-immunity protein pairs. We demonstrated that the C-terminal diversification of the PAAR-CTD proteins enriches the ecological functions of bacterial cells.
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http://dx.doi.org/10.1128/AEM.00080-21DOI Listing
February 2021

Vigilance on New-Onset Atherosclerosis Following SARS-CoV-2 Infection.

Front Med (Lausanne) 2020 20;7:629413. Epub 2021 Jan 20.

Department of Pharmacology, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, China.

The pandemic of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has become a global challenge to public health. While its typical clinical manifestations are respiratory disorders, emerging evidence of cardiovascular complications indicates the adverse interaction between SARS-CoV-2 infection and cardiovascular outcomes. Given that viral infection has emerged as an additional risk factor for atherosclerosis, in this paper, we attempt to clarify the susceptibility to new-onset atherosclerosis in individuals infected with SARS-CoV-2. Mechanistically, serving as functional receptors for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2) mediates SARS-CoV-2 infection of endothelial cells (ECs) directly, leading to endothelial dysfunction and dysregulation of the renin-angiotensin system (RAS). In addition, high expression of CD147, an alternative receptor, and activation of the NLRP3 inflammasome may also contribute to atherosclerosis in the context of COVID-19. More importantly, SARS-CoV-2 attacks the immune system, which results in excessive inflammation and perpetuates a vicious cycle of deteriorated endothelial dysfunction that further promotes inflammation. The alterations in the blood lipid profile induced by COVID-19 should not be ignored in assessing the predisposition toward atherosclerosis in victims of COVID-19. A better understanding of the underlying mechanisms of SARS-CoV-2 infection and the long-term monitoring of inflammatory factors and endothelial function should be considered in the follow-up of patients who have recovered from COVID-19 for early detection and prevention of atherosclerosis.
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http://dx.doi.org/10.3389/fmed.2020.629413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855580PMC
January 2021

Tuina for diabetes with obesity: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jan;100(3):e23918

Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Obesity is an independent risk factor for the occurrence and development of diabetes. Patients with diabetes combined with obesity will face serious burdens such as increase in insulin resistance and difficulty in blood glucose control. As a safe, effective, economical, and simple intervention, Tuina is more acceptable to the public than drugs. The objective of this systematic evaluation and meta-analysis is to evaluate the efficacy and safety of Tuina for diabetes with obesity.

Methods: We will search the following electronic databases: PubMed, Embase, Cochrane Library, Web of science, Chinese National Knowledge Infrastructure (CNKI), Sino Med, Wanfang, Chinese Clinical Trial Registry System, China Biomedical Literature Database (CBM). The time limit for retrieving studies is from establishment to November 2020 for each database. Randomized controlled clinical trials related to Tuina intervention on diabetes with obesity will be included. Data synthesis, sensitivity analysis, subgroup analysis as well as the assessment of bias risk will be conducted by using Stata V.13.0 and Review manager 5.3 software.

Results: This study will provide a quantitative and standardized evaluation for the efficacy of Tuina therapy on diabetes with obesity.

Conclusion: This systematic review and meta-analysis will provide the high-quality evidence of whether Tuina is an effective intervention for diabetes with obesity.

Registration Number: INPLASY2020110106.
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http://dx.doi.org/10.1097/MD.0000000000023918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837875PMC
January 2021

Application of a novel transcanal keyhole technique in endoscopic cholesteatoma surgery.

Acta Otolaryngol 2021 Apr 27;141(4):328-333. Epub 2021 Jan 27.

ColIege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.

Background: It is difficult to deal with epitympanic cholesteatoma in otologic surgery. The keyhole technique can realize minimally invasive surgery and reconstruct the middle ear canal.

Objective: To explore the clinical application of keyhole technique in primary and second-look surgery in middle ear cholesteatoma.

Materials And Methods: 34 cases were analyzed retrospectively in terms of residual and recurrence rate, safety (adverse events) and hearing performance at long-term follow-up. The application of the technique in primary or second stage operation was evaluated and the operation was performed by transanal endoscopy or combined approach.

Results: The cholesteatoma revealed by CT before operation was limited to the attic in 23 patients, of which 16 had the same imaging range as that of the keyhole technique. The preoperative imaging findings of 11 showed that the attic cholesteatoma may have extended into the mastoid, of which only 6 cases were confirmed by keyhole technique. An endoscopic second-look surgery using the keyhole technique was performed for these patients, 2 were confirmed to have residual lesions in the attic.

Conclusions: The keyhole technique under otoendoscopy can be used flexibly and conveniently in the second-look surgery to make up for the shortage of diffusion-weighted magnetic resonance imaging.
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http://dx.doi.org/10.1080/00016489.2021.1871777DOI Listing
April 2021

Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.

Mol Neurobiol 2021 Jan 26. Epub 2021 Jan 26.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 210002, Jiangsu, China.

To determine the functional connectome change pattern based on subregions of the hippocampus in young APOEε4 carriers during a 3-year follow-up. All the participants (n = 213) were tested for resting-state functional MRI, neuropsychological scales, and APOE genotype. The age- and sex-matched APOE ε4/ε3 (23.9 ± 3.2 years old, 6 female/7 male) carriers and APOE ε3/ε3 (22.9 ± 1.6 years old, 7 female/12 male) carriers were finally followed up. The hippocampus and its anterior/middle/posterior subregion-based functional connectivity (FC) patterns were compared between APOEε4 and APOEε3 groups by a two-sample t-test at baseline and mixed-effect analysis at follow-up. The effective connectivity (EC) patterns among the altered regions of interaction effect were examined in the APOEε4 groups. APOEε4 carries displayed saliently enhanced FC in the right anterior/middle hippocampus and core regions of the default mode network (DMN) (P < 0.05 by Gaussian Random Fields (GRF) correction). However, the APOEε4-by-time interaction was evident in the middle/posterior hippocampus with connection to the lateral temporal lobe and anterior cingulate cortex (ACC) (P < 0.05 by GRF correction). Moreover, the APOEε4 group at follow-up showed increased EC separately from both the left middle hippocampus and lateral temporal lobe to the left posterior hippocampus, and its changes of FC/EC significantly correlated with altered memory function. The posterior hippocampus might be especially vulnerable to early modulation in young APOEε4 carriers. Its connection with the lateral temporal lobe, rather than with DMN, might be the early compensative mechanism of memory function regulation influenced by APOE ε4 in the young adults.
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http://dx.doi.org/10.1007/s12035-021-02292-2DOI Listing
January 2021

-Substituted benzenesulfonamide: a potent scaffold for the development of metallo-β-lactamase ImiS inhibitors.

RSC Med Chem 2020 Feb 10;11(2):259-267. Epub 2020 Jan 10.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education , College of Chemistry and Materials Science , Northwest University , Xi'an 710127 , P. R. China . Email:

Metallo-β-lactamase (MβL) ImiS contributes to the emergence of carbapenem resistance. A potent scaffold, -substituted benzenesulfonamide, was constructed and assayed against MβLs. The twenty-one obtained molecules specifically inhibited ImiS (IC = 0.11-9.3 μM); was found to be the best inhibitor (IC = 0.11 μM), and and exhibited partially mixed inhibition with of 8.0 and 0.55 μM. The analysis of the structure-activity relationship revealed that the -substitutes improved the inhibitory activity of the inhibitors. Isothermal titration calorimetry (ITC) assays showed that reversibly inhibited ImiS. The benzenesulfonamides exhibited synergistic antibacterial effects against BL21 (DE3) cells with ImiS, resulting in a 2-4-fold reduction in the MIC of imipenem and meropenem. Also, mouse experiments showed that had synergistic efficacy with meropenem and significantly reduced the bacterial load in the spleen and liver after a single intraperitoneal dose. Tracing the ImiS in living cells by at a super-resolution level (3D-SIM) showed that the target was initially associated on the surface of the cells, then there was a high density of uniform localization distributed in the cytosol of cells, and it finally accumulated in the formation of inclusion bodies at the cell poles. Docking studies suggested that the sulfonamide group acted as a zinc-binding group to coordinate with Zn(ii) and the residual amino acid within the CphA active center, tightly anchoring the inhibitor at the active site. This study provides a highly promising scaffold for the development of inhibitors of ImiS, even the B2 subclasses of MβLs.
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http://dx.doi.org/10.1039/c9md00455fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412727PMC
February 2020

Nanosystems as curative platforms for allergic disorder management.

J Mater Chem B 2021 02;9(7):1729-1744

College of Marine Life Science, Ocean University of China, Qingdao, 266003, P. R. China.

Allergy, IgE-mediated inflammatory disorders including allergic rhinitis, asthma, and conjunctivitis, affects billions of people worldwide. Conventional means of allergy management include allergen avoidance, pharmacotherapy, and emerging therapies. Among them, chemotherapeutant intake via oral, intravenous, and intranasal routes is always the most common mean. Although current pharmacotherapy exhibit splendid anti-allergic effects, short in situ retention, low bioavailability, and systemic side effects are inevitable. Nowadays, nanoplatforms have provided alternative therapeutic options to obviate the existing weakness via enhancing the solubility of hydrophobic therapeutic agents, achieving in situ drug accumulation, exhibiting controlled and long-time drug release at lesion areas, and providing multi-functional therapeutic strategies. Herein, we highlight the clinical therapeutic strategies and deal with characteristics of the nanoplatform design in allergy interventions via intratracheal, gastrointestinal, intravenous, and ocular paths. The promising therapeutic utilization in a variety of allergic disorders is discussed, and recent perspectives on the feasible advances of nanoplatforms in allergy management are also exploited.
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http://dx.doi.org/10.1039/d0tb02590aDOI Listing
February 2021

Comparing three different phenotypic methods for accurate detection of carbapenemase-producing Enterobacterales.

J Infect Chemother 2021 Jan 16. Epub 2021 Jan 16.

Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Background: Early identification of carbapenemase-producing Enterobacterales (CPE) is highly essential to prevent their dissemination within health care settings.

Objective: This study aimed to compare 3 reported phenotypic assays for detecting carbapenemase-producing Enterobacterales (CPE).

Methods: 151 Enterobacterales isolates were collected, the sensitivity and specificity of each test was determined, with molecular genotype serving as the gold standard. The phenotypic evaluations were performed using EDTA-synergistic carbapenem inactivation method (esCIM), EDTA-carbapenem inactivation method (eCIM), and enzyme inhibitor enhancement experiment (EIE).

Results: The concordance rate was 98% for the EIE for the detection of KPC producer, and 100% for the esCIM and eCIM. Sensitivity differed among the 3 methods, and all assays had excellent sensitivity exceeding 90% for detecting metallo-β-lactamases (MBLs). The specificity of the eCIM, esCIM and EIE was 100%, 100% and 95%. Both eCIM and esCIM were unsatisfactory in detecting multi-enzyme strains (MBL and class A serine carbapenemase) (0/6). However, EIE increased the positive number to six (6/6).

Conclusions: The eCIM, esCIM and EIE can be used to accurately detect and distinguish carbapenemase and is suitable for routine use in most clinical microbiology laboratories.
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http://dx.doi.org/10.1016/j.jiac.2021.01.003DOI Listing
January 2021

Strategies for Management of Peritoneal Dialysis Patients in Singapore during COVID-19 Pandemic.

Ann Acad Med Singap 2020 12;49(12):1025-1028

Department of Renal Medicine, Singapore General Hospital, Singapore.

Peritoneal dialysis (PD) is the only well-established home-based dialysis therapy in Singapore. As it is a home-based modality, PD should be considered as a preferred mode of kidney replacement therapy (KRT) for patients with kidney failure during this COVID-19 pandemic as it avoids frequent visits to hospitals and/or satellite dialysis centres. The highly infectious nature of this virus has led to the implementation of the Disease Outbreak Response System Condition orange status in Singapore since early February 2020. This paper summarises the strategies for management of several aspects of PD in Singapore during this COVID-19 pandemic, including PD catheter insertion, PD training, home visit and assisted PD, outpatient PD clinic, inpatient management of PD patients with or without COVID-19 infection, PD as KRT for COVID-19 patients with acute kidney injury, management of common complications in PD (peritonitis and fluid overload), and management of PD inventory.
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December 2020

Promoting potential direct interspecies electron transfer (DIET) and methanogenesis with nitrogen and zinc doped carbon quantum dots.

J Hazard Mater 2021 May 27;410:124886. Epub 2020 Dec 27.

State Key Laboratory of Heavy Oil Processing, Beijing Key Laboratory of Biogas Upgrading Utilization, College of New Energy and Materials, China University of Petroleum Beijing (CUPB), Beijing 102249, China. Electronic address:

Although it has been demonstrated that one-dimensional, two-dimensional, and three-dimensional carbon nanomaterials can improve the CH production of anaerobic digestion (AD), the effect of zero-dimensional carbon nanomaterials on AD have not been reported. To expand the application of carbon nanomaterials in AD, the effect of zero-dimensional carbon nanomaterials-carbon quantum dots (CDs) on various feedstocks (c.a. cellulose, glucose, ethanol, and vinegar residue) were investigated in this study. Results have shown that CH yield from ethanol was increased by 24.59% (p = 0.396) after adding 5 g/L zinc doped carbon quantum dots (Zn-doped CDs) while that from vinegar residue was dramatically increased by 230% (p = 0.000) using 5 g/L nitrogen doped carbon quantum dots (N-doped CDs). In addition, photoluminescence demonstrated that CDs acted as a capacitor for transmitting and receiving electrons. Furthermore, co-occurrence network analysis revealed that Clostridiales might be used as a signal source to communicate with other species. This study firstly shifted the application of CDs from fluorescence to AD and manifested its positive impact on AD. In short, these findings provided a better understanding on the effects of CDs on different feedstocks of methanogenesis and revealed new evidence of stimulating methanogenesis via CDs.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124886DOI Listing
May 2021

Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy.

ACS Biomater Sci Eng 2020 09 7;6(9):4774-4798. Epub 2020 Aug 7.

College of Marine Life Science, Ocean University of China, Qingdao 266003, P.R. China.

Immunomodulatory therapeutics, which is conducive to overcoming tumor tolerance and restoring normal immune responses, has been proposed as a promising approach for enhanced cancer therapy and clinical advancement. However, issues including cytokine syndrome, inefficient delivery, hepatic dysfunction, and severe adverse reactions remain to be resolved. It is particularly critical to develop delivery technologies to overcome these limitations and further improve antitumor efficacy. With the continuous development of materials science, biomaterials have been widely used in the field of cancer treatment and have also provided exciting solutions to overcome the bottleneck of immunomodulatory therapeutics. A range of biomaterials, especially nanomaterials, has been developed as a local immunomodulatory platform to enhance targeted delivery, maintain drug stability, and reduce toxicity and side effects. In addition to single immunomodulatory therapeutics, nanomaterials have been demonstrated to possess significant potential in immunomodulatory therapeutics-based synergistic therapies, especially in combination with phototherapy, radiotherapy, chemotherapy, and immune checkpoint blockade. In this review, as background to the discussion of immunomodulatory therapeutics, we first described the mechanisms of action of multiple immunomodulators and discussed their current targeting agents. On this basis, we highlighted the latest advances in the use of nanomaterials-assisted immunomodulatory therapeutics and combination therapy to enhance anticancer immunity. In addition, current challenges and further promises for immunomodulatory therapeutics were also presented.
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http://dx.doi.org/10.1021/acsbiomaterials.0c00804DOI Listing
September 2020

The role of autophagy in bone homeostasis.

J Cell Physiol 2021 Jun 16;236(6):4152-4173. Epub 2021 Jan 16.

Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.

Autophagy is an evolutionarily conserved intracellular process and is considered one of the main catabolism pathways. In the process of autophagy, cells are digested nonselectively or selectively to recover nutrients and energy, so it is regarded as an antiaging process. In addition to the essential role of autophagy in cellular homeostasis, autophagy is a stress response mechanism for cell survival. Here, we review recent literature describing the pathway of autophagy and its role in different bone cell types, including osteoblasts, osteoclasts, and osteocytes. Also discussed is the mechanism of autophagy in bone diseases associated with bone homeostasis, including osteoporosis and Paget's disease. Finally, we discuss the application of autophagy regulators in bone diseases. This review aims to introduce autophagy, summarize the understanding of its relevance in bone physiology, and discuss its role and therapeutic potential in the pathogenesis of bone diseases such as osteoporosis.
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http://dx.doi.org/10.1002/jcp.30111DOI Listing
June 2021

Clinical Course and Risk Factors of Disease Deterioration in Critically Ill Patients with COVID-19.

Hum Gene Ther 2021 03 22;32(5-6):310-315. Epub 2021 Feb 22.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Shandong University, Qilu Hospital, Jinan, China.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019 and rapidly spread to other provinces in China as well as other countries. In this study, 262 patients diagnosed with moderate to severe SARS-CoV-2 pneumonia in Wuhan, China, were analyzed. Data were compared between survivors and nonsurvivors. Of all the 262 patients, 23 (8.8%) patients died and 239 (91.2%) were discharged. The median age was 63.5 years and 46.9% of patients were male. The main complaints were fever (83.6%), cough (63.4%), and fatigue (49.2%) in the surviving group, while there were more complaints of dyspnea (39.1%) and shortness of breath (56.5%) in the nonsurviving group. The main comorbidities were hypertension (35.5%), diabetes mellitus (16.4%), and coronary artery disease (9.9%). Morbidity is higher in elderly patients with more comorbidities. Patients were mainly treated with nasal cannula (93.9%), while the nonsurviving group received more invasive mechanical ventilation (39.1%). Arbidol (80.9%), ribavirin (36.6%), oseltamivir (38.9%), interferon (16.4%), and ganciclovir (14.5%) were used for the antiviral treatment. In the nonsurviving group, the number of white blood cells (WBC) was significantly increased and lymphocytes were decreased, and lymphopenia was more common. The levels of aspartate transaminase (AST), brain natriuretic peptide (BNP), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), and C-reactive protein (CRP) were also significantly increased in the nonsurviving group. The adjusted hazard ratios (HRs) for association of known variables for all-cause mortality due to the coronavirus disease 2019 were 2.467 (95% confidence interval [CI], 1.007-6.044;  = 0.048) for shortness of breath and 1.025 (95% CI, 1.001-1.049;  = 0.042) for AST. Elderly patients with more comorbidities and complaints of dyspnea and shortness of breath had increased risk of death. Patients with lymphopenia and high levels of WBC, AST, BNP, CK-MB, LDH, and CRP may be more likely to deteriorate.
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http://dx.doi.org/10.1089/hum.2020.255DOI Listing
March 2021

Separation of metals from Ni-Cu-Ag-Pd-Bi-Sn multi-metal system of e-waste by leaching and stepwise potential-controlled electrodeposition.

J Hazard Mater 2021 Apr 16;408:124772. Epub 2020 Dec 16.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, People's Republic of China. Electronic address:

Electronic waste, as hazardous waste, contains a large amount of metals, which is of great recovery value. However, they are difficult to separate due to wide variety and complex distribution. Most of current recycling methods are environmentally-unfriendly or complicated. In this study, a simple, efficient and green approach for metals separation from Ni-Cu-Ag-Pd-Bi-Sn multi-metal system of e-waste was proposed combining mild leaching and stepwise potential-controlled electrodeposition. The leaching efficiencies of Ni, Ag, Pd, Cu and Bi were 99.16%, 99.09%, 94.91%, 99.61% and 23.76% with 1 mol/L HNO at 80 °C. The leaching process was analyzed. It showed that the existence of Ag-Pd continuous solid solution in the alloy lowered the oxidation potential of Pd, which facilitated its leaching. Sn precipitated as SnO. Then Ag-Pd alloy and Cu-Bi alloy were separately extracted from the leaching solution by stepwise electrodeposition. 97.72% of Ag and 98.05% of Pd were recycled after 5 h with potential of 0.35 V. The recovery efficiencies of Cu and Bi were 97.87% and 97.33% after 7 h with potential of 0.05 V. The EDS results showed high purity property of Ag-Pd and Cu-Bi alloy. This process can achieve cleaner and efficient extraction of metals from multi-metal system in e-waste.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124772DOI Listing
April 2021

[Regulation Control of a Tribasic Amendment on the Chemical Fractions of Cd and As in Paddy Soil and Their Accumulation in Rice].

Huan Jing Ke Xue 2021 Jan;42(1):378-385

College of Environment Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.

A pot experiment was conducted to identify the effect of a tribasic amendment (limestone+diatomite+ferric sulfate, LDF) on chemical fractions of Cd and As in paddy soils and their accumulation in brown rice. LDF was set to seven levels (0, 0.5, 1.0, 2.0, 4.0, 8.0, and 16.0 g·kg) based on the quality ratio, and two genotypes of rice were planted (Huanghuazhan and T-you 272). The results show that:① The application of LDF increased the rhizosphere soil pH of two varieties of rice, Huanghuazhan and T-you 272, by 0.01-0.42 and 0.11-0.54, respectively, and decreased the concentrations of EX-Cd by 11.1%-61.1% and 26.5%-52.9%, respectively, and the concentrations of EX-As by 8.2%-60.0% and 5.6%-49.9%, respectively. ② Application of LDF promoted the transformation of soil Cd and As from soluble to insoluble forms. Although the trends of the rhizosphere soils of the two rice varieties were not consistent, the application of LDF could decrease the proportion of EX-Cd and increase the proportion of Fe/Mn-Cd, Org-Cd, and O-Cd, which was accompanied by the reduction of the proportion of EX-As and an increase in the proportion of Ca-As. ③ The concentrations of Cd, As, and Fe in the iron plaque decreased by applying LDF, while the concentration of Mn increased, and the maximum increase of Mn could reach 124.2%. ④ Application of LDF decreased the concentrations of Cd in brown rice of the two varieties of rice by 64.6% and 65.9%, respectively, and decreased that of As by 37.0% and 42.5%, respectively. The effect on the concentrations of inorganic As was not significant. When the application amount of LDF was 2-16 g·kg, the concentrations of Cd and inorganic As in T-you 272 brown rice were both under 0.2 mg·kg, and when the application amount was 16 g·kg, the concentrations of Cd and inorganic As in Huanghuazhan brown rice were both under 0.2 mg·kg. In actual agricultural production, the application amount of LDF can be adjusted according to the soil pollution levels and the rice varieties.
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http://dx.doi.org/10.13227/j.hjkx.202006126DOI Listing
January 2021

The complete chloroplast genome of Thunb. (Family: Saururaceae).

Mitochondrial DNA B Resour 2019 Nov 12;4(2):4004-4005. Epub 2019 Nov 12.

School of Life Sciences, Guizhou Normal University, Guiyang, China.

The chloroplast genome sequence of has been characterized from Illumina pair-end sequencing. The complete chloroplast genome was 161,090 bp in length, containing a large single-copy (LSC) region of 88,180 bp and a small single-copy (SSC) region of 19,204 bp, which were separated by a pair of 26,853 bp inverted repeat regions. Furthermore, phylogenetic analysis revealed that is a sister of .
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http://dx.doi.org/10.1080/23802359.2019.1688105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707749PMC
November 2019

High-Performance Flexible Transparent Conductive Films Enabled by a Commonly Used Antireflection Layer.

ACS Appl Mater Interfaces 2021 Jan 22;13(2):2979-2987. Epub 2020 Dec 22.

Shenzhen Engineering Lab of Flexible Transparent Conductive Films, Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, China.

Recently, silver nanowire-based transparent conductive films (AgNW-based TCFs) with excellent comprehensive performance have aroused wide and great interest. However, it is always difficult to simultaneously improve the performances of TCFs in all aspects. In this work, by introducing silica nanoparticles (SiO-NPs) with a smaller particle size, several properties of AgNW-based TCFs were optimized successfully. The transmittance and conductivity were improved simultaneously, and smaller particle size was proven to be more suitable to achieve TCFs with excellent optoelectrical properties. Typically, an AgNW/SiO-based TCF with a sheet resistance of 250 Ω/sq and transmittance of 93.6% (including the poly (ethylene terephthalate) substrate, abbreviated as PET) could be obtained by using SiO-NPs with a size of ∼21 nm, and this transmittance is even higher than that of the bare PET (91.8%) substrate. We demonstrated that the layer formed through self-assembly of SiO-NPs can cut down the light scattering on the AgNW surface through total reflection, thus leading to a low haze of AgNW/SiO-based TCFs. Very interestingly, the SiO-NPs conducted away most of the heat generated during laser ablation, protecting the AgNWs from excessive melt and PET from empyrosis, and thus ensuring the TCFs with high transmittance and patterning accuracy. Besides, AgNW/SiO-based TCFs have smaller surface roughness, better flexibility, and adhesive force. To the best of our knowledge, the comprehensive performance of the AgNW/SiO-based TCFs reaches the highest level among recently reported novel TCFs.
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http://dx.doi.org/10.1021/acsami.0c16542DOI Listing
January 2021

Selective electrochemical extraction of copper from multi-metal e-waste leaching solution and its enhanced recovery mechanism.

J Hazard Mater 2021 Apr 11;407:124799. Epub 2020 Dec 11.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, People's Republic of China. Electronic address:

Recycling activity for waste electrical and electronic equipment is always accompanied with leaching solution containing copper. Its selective extraction is of environmental and economic significance, and is beneficial for subsequent resource purification procedure. Compared with techniques such as chemical precipitation and solvent extraction, potentiostatic electrodeposition is outstanding with the advantage of high selectivity, electron as clean reagent, and minimal chemical usage. However, key factors affecting copper electrodeposition behavior as well as its kinetic process remain unclear, which blocks its further application. In this study, selective copper electrochemical extraction from multi-metal leaching solution of waste liquid crystal display panels is explored. Copper electrodeposition is analyzed from electrochemical and mass transport point of view, and the main results are summarized: (i) copper can be first electrodeposited due to its higher reduction potential compared with indium; (ii) applied potential and agitation are the most influential factors towards space-time yield and current efficiency; (iii) a semi-empirical kinetic model could quantitatively describe the influence of agitation and the time-current-concentration relationship. The model-predicted extraction rate agreed well with experimental data throughout electrodeposition; (iv) electrodeposition experiments show over 95% of copper can be selectively extracted as ultrafine copper powder (~150 nm) at 0.05 V (vs. SHE).
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http://dx.doi.org/10.1016/j.jhazmat.2020.124799DOI Listing
April 2021