Publications by authors named "Y Q Liu"

128,724 Publications

CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

Fred Hutchinson Cancer Research Center, seattle, Washington, United States.

Patients with inv(16)/CBFB-MYH11 AML are considered favorable risk, however, nearly one-third relapse despite intensive therapy. Despite efforts to define risk groups within this favorable risk cohort, CBFB-MYH11 AML patients continue to be treated as a uniform cohort. Through transcriptome sequencing of 186 patients with inv(16) AML, we demonstrate that fusion junction breakpoints (exon 5-exon 33 versus other) are highly associated with outcome. The presence of exon 17 KIT mutations provides additional prognostic significance. Additionally, we provide insights into the transcriptional landscapes that differentiate these distinct CBFB-MYH11 AML subtypes. Children's Oncology Group trials include CCG-2961 (registered at www.clinicaltrials.gov as NCT00002798), AAML03P1 (NCT00070174), AAML0531 (NCT00372593), and AAML1031 (NCT01371981).
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http://dx.doi.org/10.1182/bloodadvances.2021004965DOI Listing
September 2021

Increased dielectric performance of PVDF-based composites by electrochemical exfoliated graphite additives.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

School of mechanical engineering, Jiangsu University, #301 Xuefu Road, PR CHINA, Zhenjiang, 212013, CHINA.

Adding conductive graphene into polyvinylidene fluoride (PVDF) is an effective method to improve the dielectric properties. However, the high conductivity and uniform distribution of graphene in PVDF matrix still meet challenges. In this work, electrochemical exfoliated graphite (EEG) with good conductivity and solution dispersion is used to prepare PVDF/EEG films. By this method no specific conditions are needed such as reduction or hot press. The dielectric properties and flexibility of PVDF/EEG films of different concentrations of EEG are investigated. Especially, when EEG content is 2.6 wt%, composite film has a high dielectric constant of 86 and a low dielectric loss of 0.9 (100 Hz). Simultaneously, the tensile strength of the film was up to 55.1 MPa. The preparation method is simple and convenient, and the obtained material has high dielectric constant and tensile strength. This method paves the way for the application of flexible electronic sensing equipment.
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http://dx.doi.org/10.1088/1361-6528/ac28d9DOI Listing
September 2021

Pheophorbide co-encapsulated with Cisplatin in folate-decorated PLGA nanoparticles to treat nasopharyngeal carcinoma: Combination of chemotherapy and photodynamic therapy.

Colloids Surf B Biointerfaces 2021 Sep 18;208:112100. Epub 2021 Sep 18.

Department of Otolaryngology, Head and Neck Surgery, The 901st Hospital of the Joint Logistics Support Force of PLA, Hefei, Anhui 230031, China. Electronic address:

The adverse effect and drug resistance of Cisplatin (CDDP) could be potential reduced by delivering in targeted nanoparticles and by combining with adjuvant therapy such as photodynamic therapy. In this study, F/CDPR-NP was formulated and characterized for all the physicochemical, biological and in vivo analysis. The results obtained from various in vitro and biological studies showed that encapsulation of CDDP and PBR in PLGA nanoparticles results in controlled release of encapsulated drugs and exhibited significantly low cell viability in CNE-1 and HNE-1 cancer cells. F/CDPR-NP significantly prolonged the blood circulation of the encapsulated drugs. The AUC of CDDP from F/CDPR-NP (4-fold) was significantly higher compared to that of free CDDP and similarly significantly higher t1/2 for CDDP from F/CDPR-NP was observed. F/CDPR-NP in the presence of laser irradiation showed significant reduction in the tumor burden with low tumor cell proliferations compared to either CDPR-NP or free CDDP indicating the potential of targeted nanoparticles and photodynamic therapy. Overall, combination of treatment modalities and active targeting approach paved way for the higher antitumor activity in nasopharyngeal carcinoma model. The positive results from this study will show new horizon for the treatment of other cancer models.
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http://dx.doi.org/10.1016/j.colsurfb.2021.112100DOI Listing
September 2021

Highly accurate diagnosis of lung adenocarcinoma and squamous cell carcinoma tissues by deep learning.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 14;265:120400. Epub 2021 Sep 14.

State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China.

Intraoperative detection of the marginal tissues is the last and most important step to complete the resection of adenocarcinoma and squamous cell carcinoma. However, the current intraoperative diagnosis is time-consuming and requires numerous steps including staining. In this paper, we present the use of Raman spectroscopy with deep learning to achieve accurate diagnosis with stain-free process. To make the spectrum more suitable for deep learning, we utilize an unusual way of thinking which regards Raman spectral signal as a sequence and then converts it into two-dimensional Raman spectrogram by short-time Fourier transform as input. The normal-adenocarcinoma deep learning model and normal-squamous carcinoma deep learning model both achieve more than 96% accuracy, 95% sensitivity and 98% specificity when test, which higher than the conventional principal components analysis-linear discriminant analysis method with normal-adenocarcinoma model (0.896 accuracy, 0.867 sensitivity, 0.926 specificity) and normal-squamous carcinoma model (0.821 accuracy, 0.776 sensitivity, 1.000 specificity). The high performance of deep learning models provides a reliable way for intraoperative detection of marginal tissue, and is expected to reduce the detection time and save human lives.
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http://dx.doi.org/10.1016/j.saa.2021.120400DOI Listing
September 2021

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.

Int Immunopharmacol 2021 Sep 18;100:108134. Epub 2021 Sep 18.

Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. Electronic address:

Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca channel that plays an important role in Ca influx in the majority of non-excitable cells and influences calcium signalling and cellular responses. Therefore, the purpose of the present study was to gain insight into the role of TRPC6 in the osteogenesis of periodontal ligament cells (PDLCs). By western blot and immunohistochemical staining, the protein level of TRPC6 was found to be increased in a time-dependent manner during osteoblastic differentiation of PDLCs. In addition, the TRPC6 inhibitor SKF96365 was used to block the function of TRPC6 and inhibit osteoblastic differentiation of PDLCs. The TRPC6 activator hyperforin dicyclohexylammonium salt (hyperforin DCHA) was used to activate TRPC6 and promote osteoblastic differentiation of PDLCs. In vivo, wild-type mice showed better bone regeneration than TRPC6 mice, suggesting that TRPC6 has notable osteogenic induction properties and is important for bone defect repair. In conclusion, the current data demonstrated that TRPC6 plays a significant role in osteoblastic differentiation of PDLCs, suggesting that it may be a promising therapeutic target in osteogenesis.
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http://dx.doi.org/10.1016/j.intimp.2021.108134DOI Listing
September 2021
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