Publications by authors named "Y F Lee"

47,561 Publications

Deciphering van der Waals interaction between polypropylene and carbonated fly ash from experimental and molecular simulation.

J Hazard Mater 2021 Jul 24;421:126725. Epub 2021 Jul 24.

Department of Chemistry and Chemical Engineering, Education and Research Center for Smart Energy and Materials, Inha University, Incheon 22212, South Korea. Electronic address:

Pollution emitted from power plants, including a considerable amount of fly ash (FA) and carbon dioxide (CO), annually increases and is challenging from an environmentally friendly and sustainable point of view. To date, laboratory-scaled approaches cannot efficiently replace the FA-landfilling and mitigate the stress from CO emission. Here, a practically operatable fundamental work by combining carbonated FA (C-FA)-immobilizing CO in FA-and polypropylene (PP) matrix is reported and reveals abnormal mechanical and thermal features clarified by calculating van der Waals (vdW) interaction from an atomic scale. This is the first study wherein the interaction between instantaneous dipole moment-induced PP and fillers is simulated and examined. The vdW interactions at the (hetero)interfaces are -59.66, -82.30, and -224.39 kJ mol Å for PP, calcium oxide (CaO; before carbonation), and calcium carbonate (CaCO; after carbonation), respectively, which provides concrete theoretical support for interesting findings such as the independence of tensile strength on filler loadings and "well-grown" interface-induced higher conductivity characteristics of the composites. Therefore, this work can offer practical solutions to mitigate pollution, provide a new perspective on fundamental physical interactions, and guide the development of practical next-generation composite materials.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126725DOI Listing
July 2021

The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine.

J Affect Disord 2021 Jul 20;294:592-596. Epub 2021 Jul 20.

Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.

Method: .A triangular approach integrating both anchor-based and distributive methods was used to identify meaningful change on the patient-reported Quick Inventory for Depressive Symptoms Self-Report 16-Item (QIDS-SR16) as associated with the Patient Global Impression - Severity (PGI-S). Both the QIDS-SR16 and the PGI-S are self-report measures, and were collected at five timepoints (timepoints were approximately 2-7 days apart).

Results: .A total of 297 adults with treatment-resistant depression (TRD) as part of either DSM-5-defined MDD or BD were included. The MCT for the QIDS-SR16 revealed that a mean improvement of 3.38 points from baseline was comparable to a 1-point improvement on the PGI-S. Together with an examination of the probability density function, a 3.5-point change is a reasonable MCT (i.e., 1-point PGI-S improvement) for the QIDS-SR16. A 2-point symptomatic improvement on the QIDS-SR16 was associated with no change on the PGI-S.

Conclusion: .A 3.5-point reduction in the QIDS-SR16 represents a MCT based on the PGI-S for adults with treatment-resistant MDD or BD receiving intravenous ketamine treatment at a community-based mood disorders center. These findings are limited by the post-hoc nature of this analysis and open-label case-series design. Measurement-based care decisions by patients, providers and clinicians, as well as cost/reimbursement decisions should include consideration of meaningful change along with conventional objective outcomes.
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http://dx.doi.org/10.1016/j.jad.2021.07.035DOI Listing
July 2021

Urine organic acids may be useful biomarkers for metabolic syndrome and its components in Korean adults.

Clin Chem Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Family medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Objectives: Although metabolic syndrome (MetS) and its components are defined clinically, those with MetS may have various derangements in metabolic pathways. Thus, this study aimed to evaluate the traits of urine organic acid metabolites indicating the metabolic intermediates of the pathways in the subjects with MetS.

Methods: This cross-sectional study included 246 men and 283 women in a hospital health check-up setting. Urine organic acid metabolites were assayed via high-performance liquid chromatography-mass spectrometry analyses. A high level of each metabolite was defined as the fifth quintile of the distribution.

Results: The subjects with MetS had high levels of pyruvate, α-ketoglutarate, α-ketoisovalerate, α-ketoisocaproate, formiminoglutamate, and quinolinate (odds ratios from 1.915 to 2.809 in logistic models adjusted for age and sex). Among the metabolites, pyruvate, formiminoglutamate, and quinolinate were not independent of homeostatic model assessment of insulin resistance (HOMA2-IR). Several metabolites were associated with one or more components of MetS and HOMA2-IR.

Conclusions: Urine organic acid metabolites in MetS are characterized in altered carbohydrate and amino acid metabolism. MetS shared some traits in insulin resistance. These findings may promote the understanding of the pathophysiology of MetS.
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http://dx.doi.org/10.1515/cclm-2021-0598DOI Listing
July 2021

Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer.

J Immunother Cancer 2021 Jul;9(7)

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

Background: Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have not yet been approved for clinical cancer treatment due, in part, to poor understanding of molecular determinants on statin sensitivity. Here, we investigated the potential of statins to elicit enhanced immunogenicity of -mutant ( ) tumors.

Methods: The immunogenicity of treated cancer cells was determined by western blot, flow cytometry and confocal microscopy. The immunotherapeutic efficacy of mono or combination therapy using statin was assessed in tumor models, including syngeneic colorectal cancer and genetically engineered lung and pancreatic tumors. Using NanoString analysis, we analyzed how statin influenced the gene signatures associated with the antigen presentation of dendritic cells in vivo and evaluated whether statin could induce CD8+ T-cell immunity. Multiplex immunohistochemistry was performed to better understand the complicated tumor-immune microenvironment.

Results: Statin-mediated inhibition of prenylation provoked severe endoplasmic reticulum (ER) stress by attenuating the anti-ER stress effect of mutation, thereby resulting in the immunogenic cell death (ICD) of cancer cells. Moreover, statin-mediated ICD enhanced the cross-priming ability of dendritic cells, thereby provoking CD8+ T-cell immune responses against tumors. Combination therapy using statin and oxaliplatin, an ICD inducer, significantly enhanced the immunogenicity of tumors and promoted tumor-specific immunity in syngeneic and genetically engineered tumor models. Along with immune-checkpoint inhibitors, the abovementioned combination therapy overcame resistance to PD-1 blockade therapies, improving the survival rate of tumor models.

Conclusions: Our findings suggest that mutation could be a molecular target for statins to elicit potent tumor-specific immunity.
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http://dx.doi.org/10.1136/jitc-2021-002474DOI Listing
July 2021

Retraction notice to "Dietary Allium hookeri reduces inflammatory response and increases expression of intestinal tight junction proteins in LPS-induced young broiler chickens" [Research in Veterinary Science 112C (2017) 149-155].

Res Vet Sci 2021 Jul 14. Epub 2021 Jul 14.

Animal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, USA.

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http://dx.doi.org/10.1016/j.rvsc.2021.07.011DOI Listing
July 2021
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