Publications by authors named "Xuwei Wang"

4 Publications

  • Page 1 of 1

Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy.

Biomaterials 2019 12 3;223:119473. Epub 2019 Sep 3.

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, PR China; College of Sciences, Heihe University, Heihe, 164300, PR China. Electronic address:

Drug delivery systems (DDSs) have emerged to help delivering the required cargo into the region of the tumor, achieving the objectives of extenuating the potential damage to the body and improving the therapeutic effectiveness. Here, we developed a one-pot process for encapsulating the unstable and hydrophobic d-α-Tocopherol succinate (α-TOS) in zeolitic imidazolate framework-8 (ZIF-8) compounds (defined as α-TOS@ZIF-8) and subsequently coated with a hyaluronic acid (HA) shell to form the HA/α-TOS@ZIF-8 nanoplatform. Of particular note was when the concentration of α-TOS is l mg/mL, the loading rate was high up to 43.03 wt%. The study verified that HA shell, which could act as a smart "switch" and tumor-targeted "guider", had the capacity for extending blood circulation, enhancing the tumor-specific accumulation of DDS via CD44-mediated pathway. HA shell could be disintegrated by hyaluronidase (HAase) in the tumor microenvironment (TME) and the wrapped α-TOS@ZIF-8 exposed, thus leading to the decomposition of ZIF-8 in tumor acidic microenvironment to release the loaded α-TOS. Therefore, the HA/α-TOS@ZIF-8 nanoplatform has been achieved as a tumor-specific and on-demand drug delivery system, which improved the treatment efficiency.
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http://dx.doi.org/10.1016/j.biomaterials.2019.119473DOI Listing
December 2019

Response to crizotinib in a lung adenocarcinoma patient harboring a novel - fusion variant.

Onco Targets Ther 2017 21;10:4129-4133. Epub 2017 Aug 21.

Marketing Department, Novogene Bioinformatics Institute, Beijing.

fusion is a common genetic alteration in non-small-cell lung cancer. Crizotinib, an anaplastic lymphoma kinase inhibitor, shows efficacy in the treatment of lung cancer cases with translocation. We report the response to crizotinib of a lung adenocarcinoma patient harboring a novel - fusion variant, which was different from the two common - fusion types reported in the literature. After crizotinib administration, overall recovery was good in this patient; the primary lesion was successfully treated, the lymph node metastases had disappeared, and the metabolism was normal.
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http://dx.doi.org/10.2147/OTT.S136297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571840PMC
August 2017

Identification and characterization of genes involved in the jasmonate biosynthetic and signaling pathways in mulberry (Morus notabilis).

J Integr Plant Biol 2014 Jul 6;56(7):663-72. Epub 2014 Mar 6.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400715, China.

Jasmonate (JA) is an important phytohormone regulating growth, development, and environmental response in plants, particularly defense response against herbivorous insects. Recently, completion of the draft genome of the mulberry (Morus notabilis) in conjunction with genome sequencing of silkworm (Bombyx mori) provides an opportunity to study this unique plant-herbivore interaction. Here, we identified genes involved in JA biosynthetic and signaling pathways in the genome of mulberry for the first time, with the majority of samples showing a tissue-biased expression pattern. The analysis of the representative genes 12-oxophytodienoic acid reductase (OPRs) and jasmonate ZIM-domain (JAZs) was performed and the results indicated that the mulberry genome contains a relatively small number of JA biosynthetic and signaling pathway genes. A gene encoding an important repressor, MnNINJA, was identified as an alternative splicing variant lacking an ethylene-responsive element binding factor-associated amphiphilic repression motif. Having this fundamental information will facilitate future functional study of JA-related genes pertaining to mulberry-silkworm interactions.
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http://dx.doi.org/10.1111/jipb.12166DOI Listing
July 2014

Two dimensional barcode-inspired automatic analysis for arrayed microfluidic immunoassays.

Biomicrofluidics 2013 13;7(3):34110. Epub 2013 Jun 13.

National Center for Nanoscience and Technology, Beijing 100190, China.

The usability of many high-throughput lab-on-a-chip devices in point-of-care applications is currently limited by the manual data acquisition and analysis process, which are labor intensive and time consuming. Based on our original design in the biochemical reactions, we proposed here a universal approach to perform automatic, fast, and robust analysis for high-throughput array-based microfluidic immunoassays. Inspired by two-dimensional (2D) barcodes, we incorporated asymmetric function patterns into a microfluidic array. These function patterns provide quantitative information on the characteristic dimensions of the microfluidic array, as well as mark its orientation and origin of coordinates. We used a computer program to perform automatic analysis for a high-throughput antigen/antibody interaction experiment in 10 s, which was more than 500 times faster than conventional manual processing. Our method is broadly applicable to many other microchannel-based immunoassays.
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http://dx.doi.org/10.1063/1.4811278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695989PMC
January 2014