Xuhong Cao

UNVERIFIED PROFILE

Are you Xuhong Cao?   Register this Author

Register author

Xuhong Cao

Publications by authors named "Xuhong Cao"

Are you Xuhong Cao?   Register this Author

89Publications

-Reads

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

Cell 2018 Jun;173(7):1770-1782.e14

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article
June 2018

Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.

J Clin Oncol 2018 Apr 20;36(10):991-999. Epub 2017 Dec 20.

Maha Hussain, Robert H. Lurie Comprehensive Cancer Center, Northwestern University; Walter M. Stadler, University of Chicago, Chicago; Daniel H. Shevrin, NorthShore University Health System, Evanston, IL; Maha Hussain, Stephanie Daignault-Newton, Lakshmi P. Kunju, Javed Siddiqui, Yi-Mi Wu, Dan Robinson, Robert J. Lonigro, Xuhong Cao, Scott A. Tomlins, Rohit Mehra, David C. Smith, Megan V. Caram, and Arul M. Chinnaiyan, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; Przemyslaw W. Twardowski, City of Hope Cancer Center, Duarte; Felix Y. Feng, University of California San Francisco, San Francisco, CA; Costantine Albany, Simon Cancer Center, Indiana University, Indianapolis, IN; Mark N. Stein, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ; Kathleen A. Cooney, University of Utah, Salt Lake City, UT; Bruce Montgomery, University of Washington, Seattle, WA; Emmanuel S. Antonarakis, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Paul G. Corn, University of Texas MD Anderson Cancer Center, Houston, TX; Young E. Whang, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and Karen E. Knudsen, Thomas Jefferson University, Philadelphia, PA.

View Article
April 2018

The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes.

Hum Pathol 2018 Jan 24;71:47-54. Epub 2017 Oct 24.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109; Comprehensive Cancer Center, Michigan Medicine, Ann Arbor, MI; Michigan Center for Translational Pathology, Ann Arbor, MI 48109. Electronic address:

View Article
January 2018

Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.

Cell 2017 Dec;171(7):1559-1572.e20

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA; Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA; Department of Urology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

View Article
December 2017

Programmed Death-ligand 1 Expression in Upper Tract Urothelial Carcinoma.

Eur Urol Focus 2017 Oct 13;3(4-5):502-509. Epub 2016 Dec 13.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA. Electronic address:

View Article
October 2017

Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes.

Am J Surg Pathol 2017 Jun;41(6):801-809

Departments of *Pathology §Dermatology †Comprehensive Cancer Center, University of Michigan Health System ‡Michigan Center for Translational Pathology, Ann Arbor, MI.

View Article
June 2017

Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer.

Cancer Cell 2017 04 23;31(4):532-548.e7. Epub 2017 Mar 23.

Michigan Center for Translational Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, 1400 East Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA. Electronic address:

View Article
April 2017

Next generation sequencing of extraskeletal myxoid chondrosarcoma.

Oncotarget 2017 Mar;8(13):21770-21777

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

View Article
March 2017

Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma.

J Natl Cancer Inst 2017 01 5;109(1). Epub 2016 Oct 5.

Department of Pathology, University of Michigan, Ann Arbor, MI.

View Article
January 2017

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.

Cell Rep 2016 12;17(10):2620-2631

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article
December 2016

Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer.

Eur Urol 2016 10 24;70(4):549-552. Epub 2015 Dec 24.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA. Electronic address:

View Article
October 2016

Expression of PDL1 (B7-H1) Before and After Neoadjuvant Chemotherapy in Urothelial Carcinoma.

Eur Urol Focus 2016 Feb 6;1(3):265-268. Epub 2015 Jun 6.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

View Article
February 2016

KRAS Engages AGO2 to Enhance Cellular Transformation.

Cell Rep 2016 Feb 4;14(6):1448-1461. Epub 2016 Feb 4.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article
February 2016

The central role of EED in the orchestration of polycomb group complexes.

Nat Commun 2014 ;5:3127

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [4] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [5] Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
October 2015

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

N Engl J Med 2015 Oct;373(18):1697-708

From the Institute of Cancer Research (J.M., S.C., S.S., S.M., H.M., R.P.-L., D.N.R., A.O., N.T., G.B., N.P., P.F., A.G., I.F., C.P., G.S., D.B., J.G., Z.Z., C.T.W., R.F., R.R., B.E., G.F., D. Roda, W.Y., R.B., H.P., R.A., A.S., R.E., G.A., C.J.L., A.A., E.H., J.S.B.), the Royal Marsden NHS Foundation Trust (J.M., S.S., R.P.-L., A.O., N.T., D.B., Z.Z., R.F., D. Roda, R.E., G.A., J.S.B.), and University College London Hospital (U.M.), London, Queen's University, Belfast (S.J.), University of Leeds, Leeds (C.R.), Churchill Hospital, Oxford (A.P.), University of Liverpool, Liverpool (S.H.), Beatson West of Scotland Cancer Centre, Glasgow (R.J.), and Christie Hospital, Manchester (T.E.) - all in the United Kingdom; the University of Michigan, Ann Arbor (D. Robinson, Y.-M.W., X.C., L.P.K., F.Y.F., A.M.C.); Weill Cornell Medical College, New York (M.A.R.); and Thomas Jefferson University, Philadelphia (K.E.K.).

View Article
October 2015

The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing.

Genome Res 2015 Sep 7;25(9):1372-81. Epub 2015 Aug 7.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA;

View Article
September 2015

The landscape of antisense gene expression in human cancers.

Genome Res 2015 Jul 10;25(7):1068-79. Epub 2015 Jun 10.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article
July 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article
May 2015

Targeting the MLL complex in castration-resistant prostate cancer.

Nat Med 2015 Apr 30;21(4):344-52. Epub 2015 Mar 30.

1] Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. [3] Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA. [4] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [5] Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA. [6] Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.

View Article
April 2015

The landscape of long noncoding RNAs in the human transcriptome.

Nat Genet 2015 Mar 19;47(3):199-208. Epub 2015 Jan 19.

1] Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, Ann Arbor, Michigan, USA. [3] Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. [4] Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan, USA. [5] Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA. [6] Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.

View Article
March 2015

A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer.

Neoplasia 2014 Dec;16(12):1121-7

Department of Pathology, University of Michigan Health System, Ann Arbor, MI; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI; Michigan Center for Translational Pathology, Ann Arbor, MI; Department of Urology, University of Michigan Health System, Ann Arbor, MI; Howard Hughes Medical Institute, Ann Arbor, MI. Electronic address:

View Article
December 2014

Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.

Nat Commun 2014 Dec 22;5:5893. Epub 2014 Dec 22.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [4] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
December 2014

The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer.

Mol Cancer Res 2014 Aug 16;12(8):1081-7. Epub 2014 Jul 16.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan. Department of Pathology, University of Michigan, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan. Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan.

View Article
August 2014

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer.

Nature 2014 Jun 23;510(7504):278-82. Epub 2014 Apr 23.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [4] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [5] Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
June 2014

Reconstructing targetable pathways in lung cancer by integrating diverse omics data.

Nat Commun 2013 ;4:2617

1] Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 8109, USA [2] Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA [3] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article
May 2014

Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.

Am J Pathol 2014 Mar 3;184(3):584-91. Epub 2014 Jan 3.

Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan; Department of Urology, University of Michigan Health System, Ann Arbor, Michigan; Howard Hughes Medical Institute, Ann Arbor, Michigan.

View Article
March 2014

Activating ESR1 mutations in hormone-resistant metastatic breast cancer.

Nat Genet 2013 Dec 3;45(12):1446-51. Epub 2013 Nov 3.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. [3].

View Article
December 2013

Comprehensive Analysis of ETS Family Members in Melanoma by Fluorescence In Situ Hybridization Reveals Recurrent ETV1 Amplification.

Transl Oncol 2013 Aug 1;6(4):405-12. Epub 2013 Aug 1.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI ; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI ; The Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI.

View Article
August 2013

Outlier kinase expression by RNA sequencing as targets for precision therapy.

Cancer Discov 2013 Mar 5;3(3):280-93. Epub 2013 Feb 5.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
March 2013

Detection of somatic copy number alterations in cancer using targeted exome capture sequencing.

Neoplasia 2011 Nov;13(11):1019-25

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA.

View Article
November 2011

TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers.

Cancer Res 2011 Aug 15;71(16):5387-92. Epub 2011 Jun 15.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
August 2011

Characterization of bone metastases from rapid autopsies of prostate cancer patients.

Clin Cancer Res 2011 Jun 9;17(12):3924-32. Epub 2011 May 9.

Department of Internal Medicine and Urology, University of Michigan Medical School, 7303 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

View Article
June 2011

A comparison of single molecule and amplification based sequencing of cancer transcriptomes.

PLoS One 2011 Mar 1;6(3):e17305. Epub 2011 Mar 1.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, United States of America.

View Article
March 2011

Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.

Cancer Res 2008 May;68(10):3584-90

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

View Article
May 2008

Role of the TMPRSS2-ERG gene fusion in prostate cancer.

Neoplasia 2008 Feb;10(2):177-88

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article
February 2008

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

Cancer Res 2008 Jan;68(1):73-80

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, USA.

View Article
January 2008

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.

Cancer Res 2007 Nov;67(22):10657-63

Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

View Article
November 2007

Integrative analysis of genomic aberrations associated with prostate cancer progression.

Cancer Res 2007 Sep;67(17):8229-39

Michigan Center for Translational Pathology, Department of Pathology, Department of Urology, Program of Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-0940, USA.

View Article
September 2007

Integrative molecular concept modeling of prostate cancer progression.

Nat Genet 2007 Jan 17;39(1):41-51. Epub 2006 Dec 17.

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article
January 2007

TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.

Cancer Res 2006 Apr;66(7):3396-400

Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109, USA.

View Article
April 2006