Publications by authors named "Xuelian Tian"

2 Publications

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Eye pain and blurred vision as main complaints in a new case with MDPL syndrome.

Eur J Ophthalmol 2021 Apr 16:11206721211009179. Epub 2021 Apr 16.

Department of ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Introduction: We report a novel phenotype of mandibular hypoplasia, deafness, and progeroid features with lipodystrophy (MDPL) syndrome with mutation in a Chinese girl.

Case Description: Diabetic retinopathy was detected as the primary manifestation in a Chinese girl with MDPL syndrome carrying a known mutation (c.1812_1814delCTC, p.Ser605del). Typical characteristics of the syndrome including mandibular hypoplasia, deafness, progeroid features, and diabetes were detected after comprehensive examinations. The patient suffered from blurred vision and eye pain due to the neovascularization of the retina (vitreous hemorrhage and retinal detachment) and iris (neovascular glaucoma). The literature review revealed that the prevalence of hepatomegaly and abnormal triglyceride levels were significantly higher in female than in male with MDPL syndrome carrying mutations.

Conclusion: These results expand our knowledge regarding the clinical phenotypes of MDPL syndrome with mutations. Diabetic retinopathy is a non-negligible complication of MDPL syndrome. The phenotype varies among female and male patients with the syndrome. Hepatomegaly and abnormal triglyceride levels are more common in female patients with MDPL syndrome.
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http://dx.doi.org/10.1177/11206721211009179DOI Listing
April 2021

Structure and function of mycobacterium glycopeptidolipids from comparative genomics perspective.

J Cell Biochem 2013 Aug;114(8):1705-13

Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.

Glycopeptidolipids (GPLs) attached to the outer surface of the greasy cell envelope, are a class of important glycolipids synthesized by several non-tuberculosis mycobacteria. The deletion or structure change of GPLs confers several phenotypical changes including colony morphology, hydrophobicity, aggregation, sliding motility, and biofilm formation. In addition, GPLs, particular serovar specific GPLs, are important immunomodulators. This review aims to summarize the advance on the structure, function and biosynthesis of mycobacterium GPLs.
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http://dx.doi.org/10.1002/jcb.24515DOI Listing
August 2013