Publications by authors named "Xuebin Wang"

120 Publications

Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells.

Bioengineered 2021 Oct 12. Epub 2021 Oct 12.

Department of Cardiology, Affiliated Suzhou Science and Technology City Hospital of Nanjing Medical University, Suzhou, China.

Atherosclerosis (AS) is an inflammatory disease caused by multiple factors. Multiple circRNAs are involved in the development of AS. The present study focusses on delineating the role of circ_0090231 in AS. Human aortic endothelial cells (HAECs) were treated with oxidized low-density lipoprotein (ox-LDL) to construct an AS model. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the levels of circ_0090231, IL-1β, and IL-18 transcripts. CircRNA/ target gene interactions were predicted using StarBase and TargetScan and confirmed using an RNA pull-down assay and dual luciferase reporter assay. Further, 3-(4,5)-dimethylthiahiazo(-2)-3,5-diphenytetrazoliumromide (MTT) and lactate dehydrogenase (LDH) release assays were performed to evaluate cell viability and damage in the AS model, respectively. Cell pyroptosis and protein expression were determined using flow cytometry and western blotting respectively. The treatment of HAECs with ox-LDL not only led to significant increase in the levels of circ_0090231 but also resulted in improved cell viability as well as reduced cell injury and pyroptosis as compared to that in non-treated cells. The circ_0090231 was also identified to function as a sponge for miR-635, knockdown of which reverses the effects of circ_0090231 inhibition. Furthermore, our results revealed that levels of NLRP3, a miR-635 target, are not only augmented in the AS model but its overexpression also weakens the miR-635 regulatory effects in the AS development. Taken together, the circ_0090231/miR-635/NLRP3 axis affects the development of AS by regulating cell pyroptosis, thus providing new insights into the mechanism of AS development.
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http://dx.doi.org/10.1080/21655979.2021.1989260DOI Listing
October 2021

Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis.

Pharmgenomics Pers Med 2021 3;14:1093-1106. Epub 2021 Sep 3.

Department of Pharmacy, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People's Republic of China.

Purpose: In this study, we aimed to establish a tacrolimus population pharmacokinetic model and better understand the drug-drug interaction between Wuzhi capsule and tacrolimus in Chinese renal transplant recipients.

Patients And Methods: We performed a population pharmacokinetic analysis using a non-linear mixed-effects model to determine the suitable Wuzhi capsule dose in combination with tacrolimus. Data on 1378 tacrolimus steady-state concentrations were obtained from 142 patients who received kidney transplant in Changhai Hospital and Huashan Hospital. Demographic characteristics, laboratory tests, genetic polymorphisms, and co-medications were evaluated.

Results: The one-compartment model best described data. Our final model identified creatinine clearance rate, hematocrit, Wuzhi capsule dose, genetic polymorphisms, and tacrolimus daily dose as significant covariates for tacrolimus clearance, with the value of 14.4 L h, and the between-subject variability (BSV) was 25.4%. The Wuzhi capsule showed a dose-dependent effect on tacrolimus pharmacokinetics, demonstrating a stronger inhibitory effect than inductive effect.

Conclusion: Our model can accurately describe population pharmacokinetics of tacrolimus when combined with different doses of Wuzhi capsule. Additionally, this model can be used for individualizing tacrolimus dose following kidney transplantation.
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http://dx.doi.org/10.2147/PGPM.S321997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423491PMC
September 2021

Numerical Analysis on Erosion and Optimization of a Blast Furnace Main Trough.

Materials (Basel) 2021 Aug 26;14(17). Epub 2021 Aug 26.

State Key Laboratory of Advanced Special Steel, Shanghai Key Laboratory of Advanced Ferrometallurgy, Department of Materials Engineering, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China.

The main trough of a blast furnace (BF) is a main passage for hot metal and molten slag transportation from the taphole to the torpedo and the slag handling. Its appropriate working status and controlled erosion ensure a safe, stable, high-efficiency and low-cost continuous production of hot metal. In this work, the tapping process of a main trough of a BF in the east of China was numerically studied with the help of a CFD library written in C++, called OpenFOAM, based on the use of the Finite Volume Method (FVM). The results show that turbulence intensity downstream of the hot metal impact position becomes weaker and the turbulence area becomes larger in the main trough. During the tapping, thermal stress of wall refractory reaches the maximum value of 1.7 × 107 Pa at the 4 m position in the main trough. Furthermore, baffles in the main trough placed between 5.8 m and 6.2 m were found to control and reduce the impact of the turbulence on the refractory life. The metal flowrate upstream of the baffles can be decreased by 6%, and the flow velocity on the upper sidewall and bottom wall decrease by 9% and 7%, respectively, compared with the base model. By using baffles, the minimum fatigue life of the refractory in the main trough increases by 15 tappings compared with the base model, so the period between the maintenance stops can be prolonged by about 2 days.
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http://dx.doi.org/10.3390/ma14174851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432703PMC
August 2021

FRMC: a fast and robust method for the imputation of scRNA-seq data.

RNA Biol 2021 Aug 30:1-10. Epub 2021 Aug 30.

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science & Technology, Wuhan, Hubei, China.

The high-resolution feature of single-cell transcriptome sequencing technology allows researchers to observe cellular gene expression profiles at the single-cell level, offering numerous possibilities for subsequent biomedical investigation. However, the unavoidable technical impact of high missing values in the gene-cell expression matrices generated by insufficient RNA input severely hampers the accuracy of downstream analysis. To address this problem, it is essential to develop a more rapid and stable imputation method with greater accuracy, which should not only be able to recover the missing data, but also effectively facilitate the following biological mechanism analysis. The existing imputation methods all have their drawbacks and limitations, some require pre-assumed data distribution, some cannot distinguish between technical and biological zeros, and some have poor computational performance. In this paper, we presented a novel imputation software FRMC for single-cell RNA-Seq data, which innovates a fast and accurate singular value thresholding approximation method. The experiments demonstrated that FRMC can not only precisely distinguish 'true zeros' from dropout events and correctly impute missing values attributed to technical noises, but also effectively enhance intracellular and intergenic connections and achieve accurate clustering of cells in biological applications. In summary, FRMC can be a powerful tool for analysing single-cell data because it ensures biological significance, accuracy, and rapidity simultaneously. FRMC is implemented in Python and is freely accessible to non-commercial users on GitHub: https://github.com/HUST-DataMan/FRMC.
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http://dx.doi.org/10.1080/15476286.2021.1960688DOI Listing
August 2021

Precise macroscopic supramolecular assembly of photopatterned hydrogels.

Chem Commun (Camb) 2021 Sep 12;57(70):8786-8789. Epub 2021 Aug 12.

Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130# Meilong Road, Shanghai 200237, China.

Here we demonstrate that a precise macroscopic supramolecular assembly (MSA) can be achieved using a surface photopatterning strategy. The electrostatic interaction of the photopatterned polyelectrolytes drives hydrogel cuboids to form a stable MSA on a millimeter scale and the spatial controllability of light enables the hydrogels to be assembled into complex supramolecular architectures.
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http://dx.doi.org/10.1039/d1cc03428fDOI Listing
September 2021

Development of an agglutination-enhancement immunoturbidimetric tacrolimus assay with improved sensitivity.

J Pharm Biomed Anal 2021 Oct 29;205:114290. Epub 2021 Jul 29.

Department of Laboratory and Transfusion Medicine, 988th Hospital of PLA Joint Logistics Support Force, Zhengzhou City, 450000, Henan, China.

Accurate quantification of low level of blood drugs by Latex enhanced immunoturbidimetric assay (LEITA) remains a challenge due to its inherent limited sensitivity. To deal with this problem, we designed a new agglutination-enhancement strategy, and applied it for development of a highly sensitive and accurate tacrolimus LEITA. By this principle, a very small amount of biotin labeled anti-tacrolimus monoclonal antibodies (BLATMA) can arise agglutination strong enough for accurate reading of the increased absorbance since the BLATMA bears multiple biotin molecules, and the agglutination mediated by BLATMA can be inhibited by a similarly small amount of tacrolimus when the drug binds to BLATMA, giving rise to an improved sensitivity. The limit of detection (LOD) and functional sensitivity obtained by the proposed tacrolimus LEITA was 0.22 ng/mL and 0.59 ng/mL, respectively, 8-20 times more sensitive than the conventional drug-latex or antibody-latex based direct inhibition LEITA formats. Good precision was observed in the whole range of clinically significant tacrolimus concentration. The reliability of the tacrolimus LEITA was demonstrated by its strong correlation with both liquid chromatography-tandem mass spectrometry (LC-MS/MS) (R = 0.977, slope = 0.998) and the ABBOTT tacrolimus chemiluminescent magnetic immunoassay (CMIA) (R = 0.982, slope = 1.01) in the analysis of 119 clinical samples. It's concluded that the agglutination-enhancement strategy can be applied to construct highly sensitive LEITA for accurate tacrolimus analysis; owing to the improved sensitivity, this technique can be expected not only to improve the reliability of LEITA for low-level drug monitoring, but also to broaden the scope of analytes detectable by LEITA.
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http://dx.doi.org/10.1016/j.jpba.2021.114290DOI Listing
October 2021

Chiroptical Sensing of Amino Acid Derivatives by Host-Guest Complexation with Cyclo[6]aramide.

Molecules 2021 Jul 2;26(13). Epub 2021 Jul 2.

Key Laboratory of Radiation Physics and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.

A hydrogen-bonded (H-bonded) amide macrocycle was found to serve as an effective component in the host-guest assembly for a supramolecular chirality transfer process. Circular dichroism (CD) spectroscopy studies showed that the near-planar macrocycle could produce a CD response when combined with three of the twelve L--amino acid esters (all cryptochiral molecules) tested as possible guests. The host-guest complexation between the macrocycle and cationic guests was explored using NMR, revealing the presence of a strong affinity involving the multi-point recognition of guests. This was further corroborated by density functional theory (DFT) calculations. The present work proposes a new strategy for amplifying the CD signals of cryptochiral molecules by means of H-bonded macrocycle-based host-guest association, and is expected to be useful in designing supramolecular chiroptical sensing materials.
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http://dx.doi.org/10.3390/molecules26134064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271771PMC
July 2021

formation of a biomimetic lipid membrane triggered by an aggregation-enhanced photoligation chemistry.

Chem Sci 2021 Jan 21;12(10):3627-3632. Epub 2021 Jan 21.

Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology 130# Meilong Road Shanghai 200237 China

Nature or synthetic systems that can self-assemble into biomimetic membranes and form compartments in aqueous solution have received extensive attention. However, these systems often have the problems of requiring complex processes or lacking of control in simulating lipid synthesis and membrane formation of cells. This paper demonstrates a conceptually new strategy that uses a photoligation chemistry to convert nonmembrane molecules to yield liposomes. Lysosphingomyelin (Lyso) and 2-nitrobenzyl alcohol derivatives (NBs) are used as precursors and the amphiphilic character of Lyso promotes the formation of mixed aggregates with NBs, bringing the lipid precursors into close proximity. Light irradiation triggers the conversion of NBs into reactive aldehyde intermediates, and the preassembly facilitates the efficient and specific ligation between aldehyde and Lyso amine over other biomolecules, thereby accelerating the synthesis of phospholipids and forming membrane compartments similar to natural lipids. The light-controllable transformation represents the use of an external energy stimulus to form a biomimetic phospholipid membrane, which has a wide range of applications in medicinal chemistry, synthetic biological and abiogenesis.
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http://dx.doi.org/10.1039/d0sc06049fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179432PMC
January 2021

HCMB: A stable and efficient algorithm for processing the normalization of highly sparse Hi-C contact data.

Comput Struct Biotechnol J 2021 27;19:2637-2645. Epub 2021 Apr 27.

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.

The high-throughput genome-wide chromosome conformation capture (Hi-C) method has recently become an important tool to study chromosomal interactions where one can extract meaningful biological information including P(s) curve, topologically associated domains, A/B compartments, and other biologically relevant signals. Normalization is a critical pre-processing step of downstream analyses for the elimination of systematic and technical biases from chromatin contact matrices due to different mappability, GC content, and restriction fragment lengths. Especially, the problem of high sparsity puts forward a huge challenge on the correction, indicating the urgent need for a stable and efficient method for Hi-C data normalization. Recently, some matrix balancing methods have been developed to normalize Hi-C data, such as the Knight-Ruiz (KR) algorithm, but it failed to normalize contact matrices with high sparsity. Here, we presented an algorithm, Hi-C Matrix Balancing (HCMB), based on an iterative solution of equations, combining with linear search and projection strategy to normalize the Hi-C original interaction data. Both the simulated and experimental data demonstrated that HCMB is robust and efficient in normalizing Hi-C data and preserving the biologically relevant Hi-C features even facing very high sparsity. HCMB is implemented in Python and is freely accessible to non-commercial users at GitHub: https://github.com/HUST-DataMan/HCMB.
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http://dx.doi.org/10.1016/j.csbj.2021.04.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120939PMC
April 2021

A kinetic evaluation and optimization study on NO reduction by reburning under pressurized oxy-combustion.

J Environ Manage 2021 Jul 23;290:112690. Epub 2021 Apr 23.

Consortium for Clean Coal Utilization, Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.

Pressurized oxy-combustion is an emerging and more efficient technology for carbon capture, utilization, and storage than the first generation (atmospheric) oxy-combustion. NO is a major conventional pollutant produced in pressurized oxy-combustion. In pressurized oxy-combustion, the utilization of latent heat from moisture and removal of acid gases (NOx and SOx) are mainly conducted in an integrated direct-contact wash column. Recent studies have shown that NOx particular inlet concentration should be maintained before direct contact wash column to remove NOx and SOx efficiently. As a result, minimizing NOx for environmental reasons, avoiding corrosion in carbon capture, utilization, and storage, and achieving effective NOx and SOx removal in direct contact wash columns are crucial. Reburning is a capable and affordable technology for NO reduction; however, this process is still less studied at elevated pressure, particularly in pressurized oxy-combustion. In this paper, the kinetic evaluation and optimization study on NO reduction by reburning under pressurized oxy-combustion was conducted. First, the most suitable mechanism was selected by comparing the results of different kinetic models with the experimental data in literature at atmospheric and elevated pressures. Based on the validated mechanism, a variety of parameters were studied at high pressure, i.e., comparing the effects of oxy and the air environment, different reburning fuels, residence time, HO concentration, CH/NO ratio, and equivalence ratio on the NO reduction. The results show that de-NOx efficiency in an oxy environment is significantly enhanced compared to the air environment. Improvement in the de-NOx efficiency is considerably higher with a pressure increase of up to 10 atm, but the effect is less prominent above 10 atm. The formation of HCN is significantly reduced while the N formation is enhanced as the pressure increases from 1 to 10 atm. The residence time required for the maximum NO reduction decreases as the pressure increases from 1 atm to 15 atm. At the higher pressure, the NO reduction rises prominently when the ratio of CH/NO increases from 1 to 2; however, the effect fades after that. At higher pressure, the NO reduction by CH reburning decreases as the HO concentration increases from 0 to 35%. The optimum equivalence ratio and high pressure for maximum NO reduction are 1.5 and 10 atm, respectively. This study could provide guidance for designing and optimizing a pressurized reburning process for NOx reduction in POC systems.
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http://dx.doi.org/10.1016/j.jenvman.2021.112690DOI Listing
July 2021

A Light-Operated Molecular Cable Car for Gated Ion Transport.

Angew Chem Int Ed Engl 2021 06 6;60(27):14836-14840. Epub 2021 May 6.

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Inspired by the nontrivial and controlled movements of molecular machines, we report an azobenzene-based molecular shuttle PR2, which can perform light-gated ion transport across lipid membranes. The amphiphilicity and membrane-spanning molecular length enable PR2 to insert into the bilayer membrane and efficiently transport K (EC =4.1 μm) through the thermally driven stochastic shuttle motion of the crown ether ring along the axle. The significant difference in shuttling rate between trans-PR2 and cis-PR2 induced by molecular isomerization enables a light-gated ion transport, i.e., ON/OFF in situ regulation of transport activity and single-channel current. This work represents an example of using a photoswitchable molecular machine to realize gated ion transport, which demonstrates the value of molecular machines functioning in biomembranes.
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http://dx.doi.org/10.1002/anie.202102838DOI Listing
June 2021

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells.

Aging (Albany NY) 2021 04 4;13(8):11363-11380. Epub 2021 Apr 4.

Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Substantial evidence suggests that the effects of smoking in atherosclerosis are associated with inflammation mediated by endothelial cells. However, the mechanisms and potential drug therapies for smoking-induced atherosclerosis remain to be clarified. Considering that melatonin exerts beneficial effects in cardiovascular diseases, we examined its effects on cigarette smoke-induced vascular injury. We found that cigarette smoke extract (CSE) treatment induced NLRP3-related pyroptosis in human aortic endothelial cells (HAECs). CSE also induced ROS generation and upregulated the Nrf2 pathway in HAECs. Furthermore, pretreatment of HAECs with Nrf2-specific siRNA and an Nrf2 activator revealed that Nrf2 can inhibit CSE-induced ROS/NLRP3 activation. Nrf2 also improved cell viability and the expression of VEGF and eNOS in CSE-treated HAECs. In balloon-induced carotid artery injury model rats exposed to cigarette smoke, melatonin treatment reduced intimal hyperplasia in the carotid artery. Mechanistic studies revealed that compared with the control group, Nrf2 activation was increased in the melatonin group, whereas ROS levels and the NLRP3 inflammasome pathway were inhibited. These results reveal that melatonin might effectively protect against smoking-induced vascular injury and atherosclerosis through the Nrf2/ROS/NLRP3 signaling pathway. Overall, these observations provide compelling evidence for the clinical use of melatonin to reduce smoking-related inflammatory vascular injury and atherosclerosis.
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http://dx.doi.org/10.18632/aging.202829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109127PMC
April 2021

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF‑κB signaling.

Mol Med Rep 2021 05 24;23(5). Epub 2021 Mar 24.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

Cigarette smoke (CS) exposure is a risk factor for dyslipidemia and atherosclerosis. Reduced expression of low‑density lipoprotein receptor (LDLR) in hepatocytes may be one of the underlying mechanisms for these disorders. The aim of the present study was to investigate the molecular mechanism underlying the regulatory effect of CS extract (CSE) on proprotein convertase subtilisin/kexin type 9 (PCSK9) and low LDLR expression in HepG2 cells. PCSK9 and LDLR mRNA and protein expression levels in HepG2 cells were evaluated after CSE treatment via reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. In addition, total intracellular reactive oxygen species (ROS) production was determined via 2,7‑dichlorofluorescein diacetate fluorescence. CSE significantly increased PCSK9 expression and inhibited LDLR expression in a time‑ and concentration‑dependent manner. Furthermore, CSE significantly induced ROS production and nuclear factor κB (NF‑κB) activation. However, pretreatment with a ROS scavenger or an NF‑κB inhibitor significantly attenuated the CSE‑induced changes in PCSK9 and LDLR expression. In addition, pretreatment with melatonin markedly reduced ROS production, NF‑κB activation and PCSK9 expression, and increased LDLR expression in the CSE‑treated cells. These data suggest that melatonin inhibits CSE‑regulated PCSK9 and LDLR production in HepG2 cells via ROS/NF‑κB signaling.
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http://dx.doi.org/10.3892/mmr.2021.11970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974406PMC
May 2021

Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway.

Biochem Biophys Res Commun 2021 04 25;548:127-133. Epub 2021 Feb 25.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. Electronic address:

Diabetes is a major risk factor for the development of cardiovascular disease. Diabetic patients have a higher incidence of restenosis following endovascular therapy than non-diabetic patients. Melatonin is primarily synthesized and secreted by the pineal gland and plays an important protective anti-inflammatory and antioxidant role in a variety of cardiovascular diseases. However, no studies to date have evaluated the underlying effects and molecular mechanisms of melatonin on diabetes-related restenosis. Herein, we used an in vivo model of diabetes-related restenosis and an in vitro model of high glucose-cultured vascular smooth muscle cells to investigate the anti-restenosis effect and signaling mechanisms induced by melatonin treatment. The present study provides the first evidence that melatonin attenuates restenosis following vascular injury in diabetic rats. We further investigated the underlying molecular mechanisms both in vivo and in vitro. The data suggest that the Nrf2 signaling pathway is an important molecular target for melatonin-mediated inhibition of diabetes-related restenosis after vascular injury. These findings indicate that melatonin may represent a potential candidate for the prevention or treatment of vascular diseases and restenosis following endovascular therapy, especially in diabetic patients.
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http://dx.doi.org/10.1016/j.bbrc.2021.02.070DOI Listing
April 2021

An indirect comparison by Bayesian network meta-analysis of drug-coated devices versus saphenous vein graft bypass in femoropopliteal arterial occlusive disease.

J Vasc Surg 2021 08 16;74(2):478-486.e11. Epub 2021 Feb 16.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Objective: To compare the efficacy and safety between drug-coated devices (DCDs) and bypass surgery with saphenous vein graft (BSV) in femoropopliteal arterial occlusive disease.

Methods: A Bayesian network meta-analysis and indirect comparison were performed. Randomized controlled trials of BSV, bypass surgery with prosthetic graft, bare metal stents, endoluminal bypass (covered stent), percutaneous transluminal angioplasty, and DCDs treating femoropopliteal arterial occlusive disease were collected. The primary end point was target lesion revascularization/target vessel revascularization, and secondary end points were all-cause mortality, limb salvage, and early complications (PROSPERO registry number: CRD42019136530).

Results: Forty-two trials and 6867 patients were included. The comparison of DCDs and BSV revealed no significant difference in the 1-year target lesion revascularization/target vessel revascularization (DCDs vs BSV: odds ratio [OR], 0.60; 95% credible interval [CrI], 0.16-2.39). Total early complications from BSV were significantly higher than those from DCDs (DCDs vs BSV: OR, 0.14; 95% CrI, 0.05-0.45), and the main complications of BSV were not death related. There was also no significant difference in systemic early complications (DCDs vs BSV: OR, 0.19; 95% CrI, 0.00-7.82) and 1-year amputation rate (DCDs vs BSV: OR, 2.81; 95% CrI, 0.16-89.53). The 30-day (DCDs vs BSV: OR, 0.38; 95% CrI, 0.00-110.46), 1-year (DCDs vs BSV: OR, 0.96; 95% CrI, 0.24-3.29), 2-year (DCDs vs BSV: OR, 1.60; 95% CrI, 0.64-4.95), and 5-year all-cause mortality rates (DCDs vs BSV: OR, 2.05; 95% CrI, 0.92-4.39) showed no significant differences between DCDs and BSV, although there was a noticeable tendency toward significant results of a higher 5-year mortality rate.

Conclusions: There is no significant difference between DCDs and BSV in short-term efficacy or short- and long-term mortality. Despite traditional BSV remaining the gold standard, DCDs provide a reasonable alternative therapy. In addition, the DCDs have a lower short-term morbidity associated with the procedure at the cost of the possible risk of higher long-term mortality. Clinical trials with more validity are required for a direct comparison between BSV and DCDs.
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http://dx.doi.org/10.1016/j.jvs.2020.11.054DOI Listing
August 2021

MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway.

Free Radic Biol Med 2021 03 1;165:219-228. Epub 2021 Feb 1.

Department of Anesthesiology and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong, Shanghai, 200120, China. Electronic address:

Lipopolysaccharide (LPS) has been known to cause alveolar epithelial cell (AEC) apoptosis and barrier breakdown that characterize acute lung injury (ALI) and acute respiratory distress syndrome. We aimed to investigate whether mitoquinone (MitoQ), a mitochondria-targeted antioxidant, could alleviate LPS-induced AEC damage in ALI and its underlying mechanisms. In vitro studies in AEC A549 cell line, we noted that LPS could induce dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, AEC apoptosis and barrier breakdown, which could be reversed with MitoQ and mitochondrial division inhibitor 1 treatment. Moreover, the protective role of MitoQ was attenuated with Drp1 overexpression. Nuclear factor E2-related factor 2 (Nrf2) downregulation could block the effect of MitoQ by decreasing the expression of Nrf2 target genes in LPS-treated AEC, such as heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1). Nrf2 gene knockdown in LPS-treated A549 cells prevented the protective effect of MitoQ from decreasing Drp1-mediated mitochondrial fission, AEC apoptosis and barrier breakdown. The lung protective effect of MitoQ by regulating the Drp1-mediated mitochondrial fission, AEC apoptosis and barrier breakdown was further confirmed in vivo with LPS-induced ALI mouse model. Additionally, the protective effect of MitoQ was inhibited by Nrf2 inhibitor ML385. We therefore conclude that MitoQ exerts ALI-protective effects by preventing Nrf2/Drp1-mediated mitochondrial fission, AEC apoptosis as well as barrier breakdown.
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http://dx.doi.org/10.1016/j.freeradbiomed.2021.01.045DOI Listing
March 2021

Systematic review and meta-analysis of the prevalence of venous thromboembolic events in novel coronavirus disease-2019 patients.

J Vasc Surg Venous Lymphat Disord 2021 03 9;9(2):289-298.e5. Epub 2020 Dec 9.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Background: Emerging clinical evidence has shown that patients with the novel coronavirus disease-2019 (COVID-19) have complications that include venous thromboembolism (VTE), consisting of deep vein thrombosis (DVT) and pulmonary embolism (PE). The prevalence of VTE in patients hospitalized with COVID-19 is unclear.

Methods: Eligible studies on COVID-19 were collected from PubMed, Web of Science, and Embase. Patient characteristics and information were extracted for three categories of patients: consecutive, ICU, and non-ICU group. All PEs and DVTs were diagnosed by computed tomographic pulmonary arteriography and duplex ultrasound examination, respectively. A subgroup analysis of testing strategies in ICU and non-ICU patients for PE and DVT was also performed.

Results: Forty clinical studies involving 7966 patients hospitalized with COVID-19 were included. Pooled VTE prevalence was 13% in consecutive patients (95% confidence interval [CI], 0.05-0.24; I = 97%), 7% in non-ICU patients (95% CI, 0.01-0.18; I = 93%), and 31% in ICU patients (95% CI, 0.22-0.42; I = 91%). ICU patients had the highest prevalence of PE among the three groups (17% [95% CI, 0.12-0.23] vs 8% in consecutive patients [95% CI, 0.04-0.13], 4% in non-ICU patients [95% CI, 0.01-0.08]). ICU patients also had the highest DVT prevalence (25% [95% CI, 0.14-0.37] vs 7% in consecutive patients [95% CI, 0.03-0.14], and 7% in non-ICU [95% CI, 0.02-0.14]). The subgroup analysis showed a three-fold improvement in the PE and DVT detection rates in both ICU and non-ICU patients with COVID-19 when the screening test for VTE was applied. In the settings of screening tests for VTE, ICU patients have a significantly higher prevalence of PE (37% vs 10%; P < .0001) and DVT (40% vs 12%; P = .0065) compared with non-ICU patients.

Conclusions: VTE is common in patients hospitalized with COVID-19, especially among ICU patients. Screening tests for PE and DVT may significantly improve detection rates in both ICU and non-ICU patients with COVID-19 than tests based on clinical suspicion.
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http://dx.doi.org/10.1016/j.jvsv.2020.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725061PMC
March 2021

Green development challenges within the environmental management framework.

J Environ Manage 2021 Jan 24;277:111477. Epub 2020 Oct 24.

Department of Chemical Engineering (CIT), KU Leuven, Jan De Nayerlaan 5, 2860, Sint-Katelijne-Waver, Belgium. Electronic address:

Green development of energy, water and environment systems is essential as these three systems represent the basic life needs of humankind. Therefore, environmental problems arising from each of these three systems need to be carefully addressed to preserve the energy, water and environment resources for future generations. This paper discusses some of the latest developments in three main areas of sustainability themes, namely energy, water and environment, that emerged from the 14th Sustainable Development of Energy, Water and Environment Systems (SDEWES) Conference held in 2019. As such, it acts as an editorial paper for the virtual special issue of the Journal of Environmental Management, dedicated to the SDEWES 2019 conference.
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http://dx.doi.org/10.1016/j.jenvman.2020.111477DOI Listing
January 2021

Universal scaling and phase transitions of coupled phase oscillator populations.

Phys Rev E 2020 Oct;102(4-1):042310

Department of Mathematics, Trinity College, Hartford, Connecticut 06106, USA.

The Kuramoto model, which serves as a paradigm for investigating synchronization phenomena of oscillatory systems, is known to exhibit second-order, i.e., continuous, phase transitions in the macroscopic order parameter. Here we generalize a number of classical results by presenting a general framework for analytically capturing the critical scaling properties of the order parameter at the onset of synchronization. Using a self-consistent approach and constructing a characteristic function, we identify various phase transitions toward synchrony and establish scaling relations describing the asymptotic dependence of the order parameter on the coupling strength near the critical point. We find that the geometric properties of the characteristic function, which depends on the natural frequency distribution, determine the scaling properties of order parameter above criticality.
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http://dx.doi.org/10.1103/PhysRevE.102.042310DOI Listing
October 2020

Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis (Review).

Mol Med Rep 2020 10 28;22(4):2599-2604. Epub 2020 Jul 28.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

The scavenger receptor class B type I (SR‑BI) is a multi‑ligand membrane protein receptor that binds to high‑density lipoprotein (HDL) under physiological conditions, promoting the selective uptake of cholesterol esters from HDL into cells. SR‑BI also promotes the reverse transport of excess cholesterol from peripheral tissues to the liver, contributing to the synthesis of bile acids for excretion and the removal of excess cholesterol from the body, thereby lowering the cholesterol load and exerting anti‑atherosclerotic effects. Studies in mice and humans have demonstrated that a functional defect of SR‑BI can cause atherosclerotic lesions and cardiovascular diseases, such as myocardial infarction and stroke. Additionally, SR‑BI in vascular endothelial cells promoted the deposition of low‑density lipoprotein under the endothelium. Although SR‑BI is widely expressed in various tissues and cell types throughout the body, its expression level and function vary accordingly. The present review focuses on the biological functions and mechanisms of SR‑BI in regulating atherosclerosis.
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http://dx.doi.org/10.3892/mmr.2020.11383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453654PMC
October 2020

Combustibility analysis of high-carbon fine slags from an entrained flow gasifier.

J Environ Manage 2020 Oct 30;271:111009. Epub 2020 Jun 30.

MOE Key Laboratory of Thermo-Fluid Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

The fine slag produced from the entrained flow gasifier in coal chemical industry contains a high amount of unburned carbon content, which can reach more than 40%. The coal gasification fine slag is dissipated just by land filling which occupies a lot of land. Consequently, it causes the pollution of soil, water and wastes the combustible carbon in coal gasification fine slag. It is crucial to develop an environmental friendly and economical scheme for the utilization of coal gasification fine slag. To achieve this aim, it is significant to investigate the combustibility of coal gasification fine slag and then propose a comprehensive utilization technology. In this study, the physical and chemical properties of the raw bituminous coal and the produced coal gasification fine slag, including proximate and ultimate analysis, particle size distribution, ash composition, morphology, and specific area were investigated. The combustion and co-combustion characteristics of coal gasification fine slag were analyzed by a thermo-gravimetric analyzer. A drop tube furnace and a fluidized bed reactor were employed to test the combustibility of coal gasification fine slag in a pulverized furnace and a fluidized bed furnace, respectively. Results show that the carbon content in dried coal gasification fine slag is >40% with a heating value > 16 MJ kg. Further, thermo-gravimetric analyzer test showed that the combustion property of coal gasification fine slag is worse than that of anthracite and close to that of high ash coal, and there is a non-negligible synergistic effect for raw bituminous coal and coal gasification fine slag co-firing. The combustibility test in drop tube furnace and fluidized bed reactor showed that coal gasification fine slag can be well burned in a pulverized furnace requiring combustion temperature >900 °C and oxygen concentration >10 vol%. However, the fluidized bed furnace was not appropriate for high efficiency coal gasification fine slag burning, because the unburned carbon content of fly ash after coal gasification fine slag combustion is still >14%, even at 900 °C, 21% oxygen concentration and a low fluidization number. It is suggested that coal gasification fine slag will be better to burned it in a pulverized furnace rather than fluidized furnace.
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http://dx.doi.org/10.1016/j.jenvman.2020.111009DOI Listing
October 2020

An image analysis of the major angles along the pathway of iliac veins involved in endovenous interventions.

J Vasc Surg Venous Lymphat Disord 2021 01 27;9(1):81-87. Epub 2020 Jun 27.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Objective: The specific anatomic characteristics of the iliac veins are often important reasons for stent failure. However, to the best of our knowledge, the inherent angles and configurations of the iliac veins have not been thoroughly studied.

Methods: Fifty patients without venous diseases who had undergone computed tomography urography for diagnosis of urolithiasis were included in this study. The pathways of the iliac veins were mapped out, and the major angles were measured. The factors associated with steep angles were also evaluated.

Results: There were two relatively constant angles on the right side and three on the left side along the common femoral vein, external iliac vein, and common iliac vein. All these were measured with the patients in the supine position. The angles at the inguinal region (γ) and internal-external iliac vein confluence (β) were at similar sites for both sides. There was a third angle in front of the fifth vertebra for the left side (α). The γ angle was 125.03 ± 11.68 degrees for the right side and 122.26 ± 9.64 degrees for the left side. The β angle was 136.91 ± 14.24 degrees for the right side and 125.61 ± 20.76 degrees for the left side. According to the β angle of the left side, the iliac veins could be categorized into three types. For type I, the angle was >150 degrees (14% [7/50]). For type II, it was 120 to 150 degrees (50% [25/50]). For type III, it was ≤120 degrees (36% [18/50]). The angles between the anterior border of the fifth vertebra and pelvic inlet plane (0.866; 95% confidence interval, 0.777-0.966) and age (1.087; 95% confidence interval, 1.004-1.177) were related to type III configurations on multilogistic regression analysis.

Conclusions: There were several relatively constant angles along the pathway of the iliac veins. The pathway of the left side was more complex than that of the right side. This difference in the angles might be related to the patients' age and bone structures. These angles should be considered in planning iliac vein stenting as well as in designing stents specifically for the iliac veins.
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http://dx.doi.org/10.1016/j.jvsv.2020.06.014DOI Listing
January 2021

Effect of thermal expansion additives on alleviating the ash deposition of high-sodium coal.

J Environ Manage 2020 Sep 26;269:110799. Epub 2020 May 26.

MOE Key Laboratory of Thermo-Fluid Science and Engineering, Xi'an Jiaotong University, Xi'an, China.

The high content of sodium in coal ash can induce severe ash deposit problems on heated surface. Vermiculite has been investigated to solve this problem in drop-tube furnace recently. In this work, the effects of vermiculite and perlite on appearances, inorganic mineral transformation, elemental composition change and Na capture efficiency of ash deposit were investigated. The results show that the molten deposit obtained by drop-tube furnace at 1373 K was transformed into weakly-condensed deposit and strongly-sticky deposit respectively when vermiculite and perlite were added separately. Vermiculite has a better effect on improving the ash deposition than perlite. The mechanism of alleviating the ash deposition by vermiculite and perlite is proposed as follows: (1) The interaction between ash particles is inhibited due to the combination reactions of thermal expansion additive particles with coal ash particles. (2) The coal ash particles attach to the surface and the gap of thermal expansion additive particles, forming a porous structure. (3) With vermiculite added, MgSiO (forsterite) increases the fusion point of ash deposit. NaCaMgAl(SiAl)O(OH) (pargasite) and MgFeSiO (forsterite ferroan) result in the weak viscosity of ash deposit. (4) With perlite added, silicate and sodium aluminosilicate in perlite react with coal ash to produce a large amount of amorphous substance, which can flow downwards to make the bottom deposit molten and lead to the strong viscosity of total deposit. (5) Vermiculite has a strong capacity for Na capture at 1023 K, and perlite has a strong capacity for Na capture at 1373 K.
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http://dx.doi.org/10.1016/j.jenvman.2020.110799DOI Listing
September 2020

Cigarette smoke exposure impairs lipid metabolism by decreasing low-density lipoprotein receptor expression in hepatocytes.

Lipids Health Dis 2020 May 8;19(1):88. Epub 2020 May 8.

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Background: Cigarette smoke (CS) exposure impairs serum lipid profiles and the function of vascular endothelial cells, which accelerates the atherosclerosis. However, the precise mechanism and effect on the expression of low-density lipoprotein receptor (LDLR) in the liver by CS exposure is still unclear.

Methods: In this study, adult male C57BL/6 J mice were divided into three groups, with one group being exposed to CS for 6 weeks. HepG2 cells were treated with CS extract at concentrations of 1, 2.5, 5, and 10%.

Results: The serum levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C) for the CS-exposure group were significantly higher than those in the control group (P < 0.05). Moreover, CS exposure decreased the LDLR expression in the hepatocytes and promoted inflammation in the blood vessel walls. Melatonin was intraperitoneally injected at 10 mg/kg/d for 6 weeks alongside CS exposure, and this significantly decreased the levels of TC, TGs, and LDL-C and decreased the expression of intercellular adhesion molecule-1 and the infiltration of cluster determinant 68-cells. In vitro, CS extract prepared by bubbling CS through phosphate-buffered saline decreased the LDLR expression in HepG2 cells in a time- and concentration-dependent manner, and this effect was prevented by pretreatment with 100 μM melatonin.

Conclusions: In conclusion, CS exposure impaired lipid metabolism and decreased LDLR expression in hepatocytes, and these effects could be prevented by melatonin supplementation. These findings implied that melatonin has the potential therapeutic applicability in the prevention of lipid metabolic disorder in smokers.
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http://dx.doi.org/10.1186/s12944-020-01276-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210682PMC
May 2020

Successful surgical management of coarctation of the aorta with infective endaortitis and splenic abscess: a case report.

J Int Med Res 2020 Apr;48(4):300060520910655

Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1177/0300060520910655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153188PMC
April 2020

Catalytic function of ferric oxide and effect of water on the formation of sulfur trioxide.

J Environ Manage 2020 Jun 4;264:110499. Epub 2020 Apr 4.

MOE Key Laboratory of Thermo-Fluid Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

Sulfur trioxide (SO) is not only environmentally harmful but also highly corrosive, taking a great threat to the safe operation of coal-fired power plants. A dominant pathway of SO formation in coal-fired power plant is through the catalytic oxidation of SO (SO+1/2O→SO) on the surfaces of ash particles containing FeO The catalytic formation of SO could be affected by complex atmosphere, where the effect from HO is still debatable. In this paper, density functional theory (DFT) is employed to explore the reaction pathway of SO formation catalyzed by α-FeO in complex atmosphere containing O, O, SO and HO. In order to get the stable adsorption sites of these species, the adsorption energy of potential adsorption configurations on the α-FeO (001) surface is calculated. The dissociations of O molecule on complete and defect α-FeO (001) surfaces with O vacancy are calculated, and the Langmuir-Hinshelwood and Eley-Rideal mechanisms for the O(ads) reaction with SO(ads) or SO are compared. The effect of HO besides of SO and O on the formation of SO is especially discussed. The DFT calculation results show that for the formation of SO in gas phase, the energy barrier of 'SO+1/2O→SO' is 436.75 kJ mol, in contrast, for the catalytic formation of SO on α-FeO surfaces, this energy barrier becomes an order of magnitude smaller, 24.82 kJ mol. O molecules can dissociate on the defect α-FeO (001) surface with O vacancy spontaneously, indicating that the defect α-FeO is favorable for the dissociation of O, thereby promotes the formation of SO. The energy barrier of 'SO(ads)+O(ads)→SO(ads)' through Langmuir-Hinshelwood mechanism is much higher than that of 'SO+O(ads)→SO(ads)' through Eley-Rideal mechanism. The adsorption energy on the α-FeO (001) surface of HO is much smaller than that of SO and O, indicating that HO has little effect on the adsorption of O, O, SO and eventually the heterogeneous formation of SO. The DFT analysis results in this study provide a deep understanding on the reaction pathway of SO catalytic formation by FeO.
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http://dx.doi.org/10.1016/j.jenvman.2020.110499DOI Listing
June 2020

COVID-19: Melatonin as a potential adjuvant treatment.

Life Sci 2020 Jun 23;250:117583. Epub 2020 Mar 23.

Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX 78229, USA. Electronic address:

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.
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http://dx.doi.org/10.1016/j.lfs.2020.117583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583PMC
June 2020

Hot corrosion behaviors of TP347H and HR3C stainless steel with KCl deposit in oxy-biomass combustion.

J Environ Manage 2020 Jun 11;263:110411. Epub 2020 Mar 11.

MOE Key Laboratory of Thermo-Fluid Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

Oxy-combustion is one of the most promising technologies for carbon capture and sequestration. When CO-neutral biomass is burned under oxy-combustion conditions, named "oxy-biomass combustion" a negative CO emission can be achieved. However, the high content of potassium and chlorine in biomass results in sever ash deposition and corrosion in air fired furnaces, which are further aggravated in oxy-combustion mode due to the enrichment of corrosive species by flue gas recycle. In this paper, the hot corrosion behaviors and mechanism of two representative materials (TP347H, HR3C) used for superheaters in furnaces are studied. The effects of oxy-combustion atmosphere, KCl deposition, effect of SO, effect of water vapor, and temperature on the corrosion kinetics at the starting stage are investigated. The corrosion severity of the materials was determined using the weight gain method, and the microstructures and chemical compositions of corrosion layers were characterized by the scanning electron microscopy with energy dispersive spectroscopy, and X-ray diffraction. The results show that the hot corrosion rate is significantly sped up by KCl deposition, more than five times the gas corrosion rate under the same gas composition and temperature. HR3C with higher Cr and Ni contents is more likely to form Cr enrichment on the interface between the corrosion layer and the substrate than TP347H, resulting in stronger resistance to the hot corrosion than TP347H. When the corrosion atmosphere is changed from air-combustion to oxy-combustion, the hot corrosion rate is reduced with a denser Cr oxide film and less metal sulfides. The increase of temperature in the presence of KCl deposition significantly affects the hot corrosion rate, e.g. the corrosion rate at 650 °C is 16 times higher than that at 450 °C. Water vapor and SO concentrations have opposite influences on the hot corrosion, respectively. Compared to the dry environment, a high-humidity environment decreases the hot corrosion rate; however, a higher SO concentration facilitates the sulfation of KCl deposits, leading to stronger damage to the chromium oxide film and thereby an increased hot corrosion rate.
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http://dx.doi.org/10.1016/j.jenvman.2020.110411DOI Listing
June 2020

Porous Monolithic Electrode of Ni₃FeN on 3D Graphene for Efficient Oxygen Evolution.

J Nanosci Nanotechnol 2020 Aug;20(8):5175-5181

Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructures (LSSSM), Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China.

Developing high-performance nonprecious electrocatalysts for oxygen evolution reaction (OER) is of great importance, but it remains a challenge. In this paper, we synthesize a porous monolithic catalytic electrode, which is transition metal nitride, Ni₃FeN, constructed on a 3D network-like support of the strutted graphene foam (Ni₃FeN/SG). The obtained Ni₃FeN/SG electrode shows the excellent catalytic activity and the durability for OER in alkaline solution, owing to iron incorporation, high electrical conductivity and 3D network-like structure of strutted graphene. It requires small overpotential (226 mV) to actuate 10 mA cm, superior to most recently developed catalysts and commercial RuO₂. The fabrication strategy provides a substantial way to expand 3D porous monolithic electrodes for various electrocatalytic applications.
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http://dx.doi.org/10.1166/jnn.2020.18535DOI Listing
August 2020

Environmental problems arising from the sustainable development of energy, water and environment system.

J Environ Manage 2020 Apr 4;259:109666. Epub 2019 Dec 4.

Department of Chemical Engineering (CIT), KU Leuven, Jan De Nayerlaan 5, 2860, Sint-Katelijne-Waver, Belgium. Electronic address:

Integration of energy, water and environment systems is essential in the multidisciplinary concept of sustainable development, as they represent the basic life needs of mankind. Therefore, problems arising from the sustainable development concept need to be carefully addressed to preserve the energy, water and environment resources for future generations. This article discusses some of the latest developments in three main areas of sustainability themes, namely energy, water and environment, that emerged from three Sustainable Development of Energy, Water and Environment Systems (SDEWES) conferences held in 2018. As such, it acts as an editorial paper for the virtual special issue of the Journal of Environmental Management, dedicated to the SDEWES2018 conferences.
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http://dx.doi.org/10.1016/j.jenvman.2019.109666DOI Listing
April 2020
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