Publications by authors named "Xue-Yang Zeng"

4 Publications

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Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials.

Chin Med J (Engl) 2021 07 27;134(16):1920-1929. Epub 2021 Jul 27.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China.

Background: The global pandemic coronavirus disease 2019 (COVID-19) has become a major public health problem and presents an unprecedented challenge. However, no specific drugs were currently proven. This study aimed to evaluate the comparative efficacy and safety of pharmacological interventions in patients with COVID-19.

Methods: Medline, Embase, the Cochrane Library, and clinicaltrials.gov were searched for randomized controlled trials (RCTs) in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/SARS-CoV. Random-effects network meta-analysis within the Bayesian framework was performed, followed by the Grading of Recommendations Assessment, Development, and Evaluation system assessing the quality of evidence. The primary outcome of interest includes mortality, cure, viral negative conversion, and overall adverse events (OAEs). Odds ratio (OR) with 95% confidence interval (CI) was calculated as the measure of effect size.

Results: Sixty-six RCTs with 19,095 patients were included, involving standard of care (SOC), eight different antiviral agents, six different antibiotics, high and low dose chloroquine (CQ_HD, CQ_LD), traditional Chinese medicine (TCM), corticosteroids (COR), and other treatments. Compared with SOC, a significant reduction of mortality was observed for TCM (OR = 0.34, 95% CI: 0.20-0.56, moderate quality) and COR (OR = 0.84, 95% CI: 0.75-0.96, low quality) with improved cure rate (OR = 2.16, 95% CI: 1.60-2.91, low quality for TCM; OR = 1.17, 95% CI: 1.05-1.30, low quality for COR). However, an increased risk of mortality was found for CQ_HD vs. SOC (OR = 3.20, 95% CI: 1.18-8.73, low quality). TCM was associated with decreased risk of OAE (OR = 0.52, 95% CI: 0.38-0.70, very low quality) but CQ_HD (OR = 2.51, 95% CI: 1.20-5.24) and interferons (IFN) (OR = 2.69, 95% CI: 1.02-7.08) vs. SOC with very low quality were associated with an increased risk.

Conclusions: COR and TCM may reduce mortality and increase cure rate with no increased risk of OAEs compared with standard care. CQ_HD might increase the risk of mortality. CQ, IFN, and other antiviral agents could increase the risk of OAEs. The current evidence is generally uncertain with low-quality and further high-quality trials are needed.
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http://dx.doi.org/10.1097/CM9.0000000000001672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382475PMC
July 2021

[Visual analysis of knowledge map of network Meta-analysis in traditional Chinese medicine based on CiteSpace].

Zhongguo Zhong Yao Za Zhi 2020 Sep;45(18):4500-4509

Institute of Public Health, Peking University Beijing 100191, China Center for Evidence Based Medical and Clinical Research, Peking University Beijing 100191, China.

Network Meta-analysis has been widely applied in the field of traditional Chinese medicine(TCM) due to its unique advantages. This study aimed to conduct a visual analysis on the state of the application network Meta-analysis in the field of traditional Chinese medicine. Databases of CNKI and Web of Science were retrieved to identify the qualified literatures and then screen out their titles and abstracts. Institutions, authors, cited references, and keywords were analyzed using the information visualization analysis software CiteSpace. Finally, 79 English and 186 Chinese articles were included. The results indicated that the literatures were mainly published in Chinese, and the number of articles was increased rapidly since 2015. Cooperation between institutions and authors were mainly concentrated inside the institutions. The most important four institutions were four universities who attached more importance to evidence-based medical education and academic exploration. The keywords beside the method of network Meta-analysis could be summarized into three types: the main interventions in traditional Chinese medicine(Chinese herbal injection, herb medicine, acupuncture, etc.), disease types(cancer, circulatory system disease, bone joint disease, urinary system disease, etc.) and the outcome of interests(efficacy, safety, symptom, survive, mortality, etc.), which reflected the current research hotspots to certain extent. In addition, the most cited articles were methodology articles, including the introduction of methodology and the guides of application software, suggesting that the exploration of methodological articles will be extremely concerned.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200324.501DOI Listing
September 2020

[Critical quality evaluation and application value of network Meta-analyses in traditional Chinese medicine].

Zhongguo Zhong Yao Za Zhi 2019 Dec;44(24):5322-5328

Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.

To introduce the application status of network Meta-analysis( NMA) in the field of traditional Chinese medicine,and to discuss the application value of NMA in the field of traditional Chinese medicine,this study comprehensively reviewed the systematic reviews with application of NMA in the field of traditional Chinese medicine. CNKI,Wan Fang,Sino Med,VIP,Embase,PubMed and Cochrane Library and the reference list of previous studies were searched. The AMSTAR scale was used to evaluate the quality of literature methodology,and PRISMA-NMA checklist was used to measure the degree of report specification. Overall,122 articles were included,including 80 in Chinese and 42 in English. The included studies centered on cancer,bone and joint disease,cardiovascular disease,respiratory disease,mental disease and digestive disease. Additionally,the intervention can be categorized into three groups,traditional Chinese medicine injection,oral Chinese medicine or prescription,and traditional physical therapy including acupuncture.Nearly one-third of the researches' intervention program is aimed at comparing the effect of Chinese and Western combined therapy and monotherapy. The overall methodology quality grade is medium and the report quality is average,with methodology reporting and result reporting especially need to be improved. The subgroup analysis shows that the methodology quality of the English literatures is evidently higher than Chinese literatures,and the quality of the literatures published after 2015 is higher than those published in or before 2015.This study indicates that the NMA can compare multiple treatments simultaneously,which accords with characteristics of the clinical practice in traditional Chinese medicine that is complex and individual. NMA in the field of traditional Chinese medicine is still in the process of development. With higher level of quality control and reporting as well as the improvement of the statistical methodology and the accumulation of original researches,NMA application in the field of traditional Chinese medicine will be promising.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191022.501DOI Listing
December 2019

[Phosphate Removal on Zirconium Alginate/Poly(-isopropyl acrylamide) Hydrogel Beads with a Semi-interpenetrating Network].

Huan Jing Ke Xue 2018 Jun;39(6):2748-2755

School of Civil Engineering, Guangzhou University, Guangzhou 510006, China.

Zirconium alginate/poly(-isopropyl acrylamide) hydrogel beads with a semi-interpenetrating network (ZA/PNIPAM) were prepared by using the ionic crosslinking and radical polymerization method and investigated for phosphate removal from aqueous solutions. The effects on the adsorption performance of hydrogel beads, including initial pH, adsorbent dose, initial phosphate concentration, and co-existing anions, were evaluated systematically. Results showed that the ZA/PNIPAM could exhibit a maximum uptake capacity of phosphate at pH 2.The uptake capacity of the adsorbent increased with a decrease in the dose or an increase in the initial phosphate concentration. The presence of SO had a more negative effect on phosphate removal compared to Cl and NO. The kinetics fitted a pseudo-second-order model and intraparticle diffusion model, suggesting the adsorption rate was mainly controlled by surface adsorption and diffusion into the interior of the hydrogel beads. The isotherm data could be described by the Freundlich model, indicating that the adsorption process was heterogeneous multilayer adsorption. The studies of FTIR, XPS, and zero point of charge with relevant adsorption data revealed that the phosphate adsorption mechanisms could be electrostatic attraction (physical adsorption) and ligand exchange reactions (chemical adsorption). After four cycles of regeneration, ZA/PNIPAM exhibited a stable uptake capacity, indicating favorable reusability.
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http://dx.doi.org/10.13227/j.hjkx.201711071DOI Listing
June 2018
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