Publications by authors named "Xue Li"

2,222 Publications

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A Pilot Study Investigating the Expression Levels of Pluripotency-Associated Genes in Rectal Swab Samples for Colorectal Polyp and Cancer Diagnosis and Prognosis.

Stem Cells Int 2021 22;2021:4139528. Epub 2021 Jul 22.

Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Change in gene expression is inevitable in cancer development. With more studies demonstrating the contributions of cancer stem cells (CSCs) in colorectal cancer (CRC) development, this study is aimed at investigating whether rectal swab specimen serves as a tool for detection of dysregulation of CSC or stem cell (SC) markers and at evaluating its potential as a new promising screening method for high-risk patients. Expression levels of 15 pluripotency-associated genes were assessed by quantitative PCR in 53 rectal swab specimens referred for endoscopic screening. Dysregulated genes and joint panels based on such genes were examined for their diagnostic potentials for both polyp and CRC. Out of 15 genes, , , , and showed significantly differential expression among normal, polyp, and CRC patients. A panel of and showed an AUC value of 0.80 ( = 0.003) in identifying CRC patients from polyp/normal subjects, with sensitivity and specificity of 84.6% and 69.2%. A panel of and achieved CRC/polyp identification with an AUC value of 0.79 ( = 0.002), with a sensitivity of 82.8% and specificity of 80.0%. The sensitivity for polyp and CRC was 80.0% and 85.7%, respectively. Further analysis showed that higher and level was detected in normal subjects who developed polyps after 5-6 years, in comparison with subjects with no lesion developed, and the AUC of the and panel increased to 0.88 ( < 0.001), with sensitivity and specificity of 84.4% and 92.3%, respectively, when these patients were included in the polyp group. This study suggests that the and panel is a promising biomarker for distinguishing CRC from normal and polyp patients, whereas the and panel may identify polyp and CRC from normal individuals.
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http://dx.doi.org/10.1155/2021/4139528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324395PMC
July 2021

Mechanism of Anti-Inflammatory and Antibacterial Effects of QingXiaoWuWei Decoction Based on Network Pharmacology, Molecular Docking and Experiments.

Front Pharmacol 2021 15;12:678685. Epub 2021 Jul 15.

The Center for New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot, China.

QingXiaoWuWei Decoction (QXWWD) is a traditional Chinese medicine that is commonly used in clinical settings to treat inflammatory and bacterial diseases. However, there is still a lot to learn about its molecular mechanism. A network pharmacology approach was applied to investigate the pharmacological mechanisms of QXWWD in inflammation treatment. The basic mechanisms involved in the anti-inflammatory and antibacterial potentials of QXWWD were identified using network pharmacology and molecular docking. The principal components of QXWWD were identified by the HPLC-Q-Exactive-MS method. The antibacterial bioactivity of QXWWD was further investigated using the Kirby-Bauer disc diffusion method and the determination of the minimum inhibitory concentration. The anti-inflammatory activity of QXWWD was evaluated using mice ear swelling test, RAW264.7 cell culture, and pro-inflammatory cytokines measurement. Skin irritation and HE staining were employed to evaluate the safety of QXWWD topical use and to depict the drug's potential therapeutic function. The hub genes and signaling pathways associated with inflammatory and bacterial diseases were validated by western blot in addition to biochemical and pathological markers. Our findings revealed that the ethanolic extract of QXWWD had a strong inhibitory effect against , , Meanwhile, QXWWD was potentially effective in suppressing ear swelling, elevated white blood cell counts, and the TNF-α, IL-1, and IL-6 levels. According to skin irritation, QXWWD was found to be safe when tested for topical application. The results of HE staining showed that the possible therapeutic role of QXWWD was related to the change in skin microstructure. Also, the network pharmacology, molecular docking as well as Q-Exactive-MS and HPLC analysis suggested that the synergistic effect of quercetin, luteolin and other ingredients could serve as main contributor of QXWWD for its anti-inflammatory and antibacterial activities. Moreover, the JUN, MAPK1, RELA, NFKBIA, MYC, and AKT1 were the potential identified key targets, and MAPK/PI3K/Akt was among the possibly involved signaling pathways in the anti-inflammatory and antibacterial activities of QXWWD. From a therapeutic standpoint, QXWWD may be a promising antibacterial and anti-inflammatory agent for the treatment of bacterial, acute, and chronic dermatitis.
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http://dx.doi.org/10.3389/fphar.2021.678685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320847PMC
July 2021

A light-initiated chemiluminescent assay for the detection of children's milk protein-specific IgE with excellent ability to avoid interference of specific IgG.

J Immunol Methods 2021 Jul 29:113110. Epub 2021 Jul 29.

School of Medical Laboratory, Tianjin Medical University, Tianjin, China.

The detection of allergen-specific IgE is of value for the diagnosis of children's milk allergy. However, its accuracy will interfere with the presence of high levels of specific IgG in the serum of children with milk allergy. To solve this problem, we established a light-initiated chemiluminescent assay (LICA) based on nanomicrospheres, which neutralized the interference of specific IgG by increasing the amount of antigen coated on the microspheres. The ability of this method to resist IgG interference was confirmed by adding extra specific IgG to the serum of allergic patients. Finally, the positive rate of allergen-specific IgE was increased to 85%, which was better than the indirect ELISA (70%), indicating that this method has certain advantages for the detection of specific IgE in children with milk allergy.
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http://dx.doi.org/10.1016/j.jim.2021.113110DOI Listing
July 2021

Health-related risky behaviors in Chinese adolescents with autism: a cross-sectional study.

Child Adolesc Psychiatry Ment Health 2021 Jul 30;15(1):39. Epub 2021 Jul 30.

Peking University Institute of Mental Health, Peking University Sixth Hospital, Key Laboratory of Mental Health, National Health Commission (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), No. 51 Huayuan North Road, Haidian District, Beijing, 100191, China.

Background: Health-related risky behaviors (HRB) generally refer to behaviors that have a negative influence on health and quality of life. HRB in adolescents with autism have not been well understood so far. We aim to explore health-related risky behaviors and their risk factors with autistic adolescents.

Methods: In this study, 150 adolescents with autism and 150 neurotypical adolescents were enrolled. Participants in both groups completed the Adolescent Health-Related Risky Behavior Inventory (AHRBI). Autism Spectrum Screening Questionnaire (ASSQ), Wechsler Intelligence Scale, Theory of Mind (ToM) Test, Zung Self-rating Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS), and Self-Esteem Scale (SES) were also assessed in the autism group to explore risk factors.

Results: The results showed that the total score of AHRBI and scores of "aggression and violence (AV)", "suicide or self-injury (SS)", "health-compromising behavior (HCB)", and "unprotected sex (US)" subscales in the autism group were significantly higher than those in the control group (Z value = - 4.58 ~ - 2.26, all P < 0.05). Anxiety, depression, low self-esteem, low IQ score, low ToM test score, increasing age, and communication disorder were found as risk factors for health-related risky behaviors in autistic adolescents.

Conclusions: Adolescents with autism have more health-related risky behaviors than neurotypical adolescents. We should pay attention to the emotional state, self-esteem, cognitive function, and verbal communication levels of autistic adolescent with health-related risky behaviors.
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http://dx.doi.org/10.1186/s13034-021-00390-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325271PMC
July 2021

A multifunctional CuSn interface layer for dendritic-free lithium metal anode.

J Colloid Interface Sci 2021 Jul 23;605:223-230. Epub 2021 Jul 23.

College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, PR China. Electronic address:

The unstable electrode/electrolyte interface of the lithium metal anode is one of the reasons that induce the formation of lithium (Li) dendrites. The Li dendrites will reduce the coulombic efficiency, and even pierce the separator to cause the safety problems. Herein, a tightly bonded and uniformly distributed CuSn interface layer is formed on the surface of the Cu foam by a simple electroless plating method. The composite layer has multiple functions, such as high lithiophilicity, high carrier transport and high adaptability to mechanical strain. Based on the versatility of the CuSn interface layer, the cycle life of Cu foam is increased from 150 h to 1000 h, and the deposition overpotential is as low as 18 mV. In-situ online observation proves that the existence of composite layer can make Li metal uniformly deposited to avoid the dendrites. Furthermore, [email protected] foam also shows a higher capacity retention rate (increased from 65.2% to 78.6% after 300 cycles) and a more stable rate performance when it is used in full batteries. Compared with the single function improvement strategy proposed by the current lithium metal anode research. The CuSn multifunctional composite layer modification method in this work provides a new strategy for constructing a stable electrode/electrolyte interface.
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http://dx.doi.org/10.1016/j.jcis.2021.07.108DOI Listing
July 2021

Different characteristics of individual particles from light-duty diesel vehicle at the launching and idling state by AAC-SPAMS.

J Hazard Mater 2021 Jun 10;418:126304. Epub 2021 Jun 10.

Institute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou 510632, PR China.

The rapid development of cities and economic prosperity greatly motivates the growth of vehicular exhaust particles, especially the diesel-exhausted particles from the large fleet of passenger and freight, which present profound implications on climate, air quality, and biological health (e.g., pulmonary, autoimmune and cardiovascular diseases). As important physiochemical properties of atmospheric aerosols, however, the mixing state and effective density of individual particles emitted from diesel-powered vehicles under different driving conditions and their environmental implications remain uncertain. Here, a single-particle aerosol mass spectrometer (SPAMS) was used to investigate the chemical composition and vacuum aerodynamic diameter (D), along with the aerodynamic diameter (D) from an aerodynamic aerosol classifier (AAC), to determine the effective density of primary particles emitted from a light- duty diesel vehicle (LDDV) under the launching and idling engine states. Interestingly, the particle types and effective density appear to vary significantly with the engine status. A single particle type of Ca-rich particles, named Na-Ca-PAH, was predominant in the idling state, whose chemical components may be affected by the lubricants and incomplete combustion, contributing to a higher effective density (0.66 ± 0.21 g cm). In contrast, launching particles exhibited a lower effective density (0.34 ± 0.17 g cm) because of the substantial elemental carbon (EC). In addition, the effective density depends not only on the particle size but also on the chemical components with various abundances. EC and Ca play opposite roles in the effective density of LDDV emissions. Notably, a higher proportion of polycyclic aromatic hydrocarbons (PAHs) was observed in the idling particles, contributing to 78 ± 1.2%. Given the high contribution to these PAH-containing particles in the idling state, indispensable precautions should be taken at bus stops or waiting for pedestrians. This study provides more comprehensive insights into the initial characteristics of LDDV particles due to the launching and idling states, which is beneficial for improving the model results of source apportionment and understanding its environmental behavior regarding human health.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126304DOI Listing
June 2021

Design and Implementation of Human Motion Recognition Information Processing System Based on LSTM Recurrent Neural Network Algorithm.

Authors:
Xue Li

Comput Intell Neurosci 2021 6;2021:3669204. Epub 2021 Jul 6.

Department of Physical Education, Xi'an International Studies University, Xi'an 710128, Shaanxi, China.

With the comprehensive development of national fitness, men, women, young, and old in China have joined the ranks of fitness. In order to increase the understanding of human movement, many researches have designed a lot of software or hardware to realize the analysis of human movement state. However, the recognition efficiency of various systems or platforms is not high, and the reduction ability is poor, so the recognition information processing system based on LSTM recurrent neural network under deep learning is proposed to collect and recognize human motion data. The system realizes the collection, processing, recognition, storage, and display of human motion data by constructing a three-layer human motion recognition information processing system and introduces LSTM recurrent neural network to optimize the recognition efficiency of the system, simplify the recognition process, and reduce the data missing rate caused by dimension reduction. Finally, we use the known dataset to train the model and analyze the performance and application effect of the system through the actual motion state. The final results show that the performance of LSTM recurrent neural network is better than the traditional algorithm, the accuracy can reach 0.980, and the confusion matrix results show that the recognition of human motion by the system can reach 85 points to the greatest extent. The test shows that the system can recognize and process the human movement data well, which has great application significance for future physical education and daily physical exercise.
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http://dx.doi.org/10.1155/2021/3669204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277512PMC
August 2021

Magnetic anisotropy and critical behavior of the quaternary van der Waals ferromagnetic material CrGeSiTe.

J Phys Condens Matter 2021 Jul 28. Epub 2021 Jul 28.

Beijing National Laboratory for Condensed Matter Physics, Chinese Academy of Sciences Institute of Physics, Institute of Physics Chinese Academy of Sciences, Beijing 100190, Beijing, 100190, CHINA.

Recently, two-dimensional ferromagnetism in the family of Chromium compounds CrXTe(X=Si, Ge) has attracted a broad research interest. Despite the structural similarity in CrTeoctahedra, the size effect of inserted Ge or Si dimer contributes to significant differences in magnetism. Here, we report a new family of quaternary van der Waals ferromagnetic material CrGeSiTe(δ<0.2) synthesized by flux method. Ge substitution in Si site results in the lattice expansion, further increasing the Curie temperature and reducing the magnetic anisotropy. The critical behavior of CrGeSiTehas been studied by specific heat as well as magnetization measurements. And the extracted critical exponents are self-consistent and well-obeying the scaling laws, which are closer to the 2D Ising model with interaction decaying as J(r) ≈ r.
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http://dx.doi.org/10.1088/1361-648X/ac1882DOI Listing
July 2021

Stability and Hopf Bifurcation Analysis of an Epidemic Model with Time Delay.

Comput Math Methods Med 2021 1;2021:1895764. Epub 2021 Jul 1.

College of Computer Science and Technology, Harbin Engineering University, Harbin 150001, China.

Epidemic models are normally used to describe the spread of infectious diseases. In this paper, we will discuss an epidemic model with time delay. Firstly, the existence of the positive fixed point is proven; and then, the stability and Hopf bifurcation are investigated by analyzing the distribution of the roots of the associated characteristic equations. Thirdly, the theory of normal form and manifold is used to drive an explicit algorithm for determining the direction of Hopf bifurcation and the stability of the bifurcation periodic solutions. Finally, some simulation results are carried out to validate our theoretic analysis.
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http://dx.doi.org/10.1155/2021/1895764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270706PMC
July 2021

High Prevalence of Extended-Spectrum Beta-Lactamases in Strains Collected From Strictly Defined Community-Acquired Urinary Tract Infections in Adults in China: A Multicenter Prospective Clinical Microbiological and Molecular Study.

Front Microbiol 2021 7;12:663033. Epub 2021 Jul 7.

Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: The objective of the study was to investigate the antimicrobial susceptibility and extended-spectrum beta-lactamase (ESBL) positive rates of from community-acquired urinary tract infections (CA-UTIs) in Chinese hospitals.

Materials And Methods: A total of 809 isolates from CA-UTIs in 10 hospitals (5 tertiary and 5 secondary hospitals) from different regions in China were collected during the period 2016-2017 according to the strict inclusion criteria. Antimicrobial susceptibility testing was carried out by standard broth microdilution method. Isolates were categorized as ESBL-positive, ESBL-negative, and ESBL-uncertain groups according to the CLSI recommended phenotypic screening method. ESBL and AmpC genes were amplified and sequenced on ESBL-positive and ESBL-uncertain isolates.

Results: The antimicrobial agents with susceptibility rates of greater than 95% included imipenem (99.9%), colistin (99.6%), ertapenem (98.9%), amikacin (98.3%), cefmetazole (97.9%), nitrofurantoin (96%), and fosfomycin (95.4%). However, susceptibilities to cephalosporins (varying from 58.6% to 74.9%) and levofloxacin (48.8%) were relatively low. In the phenotypic detection of ESBLs, ESBL-positive isolates made up 38.07% of strains isolated from CA-UTIs, while 2.97% were ESBL-uncertain. Antimicrobial susceptibilities of imipenem, cefmetazole, colistin, ertapenem, amikacin, and nitrofurantoin against ESBL-producing strains were greater than 90%. The percentage of ESBL-producing strains was higher in male (53.6%) than in female patients (35.2%) ( < ). CTX-M-14 (31.8%) was the major CTX-M variant in the ESBL-producing , followed by CTX-M-55 (23.4%), CTX-M-15 (17.5%), and CTX-M-27 (13.3%). The prevalence of carbapenem-resistant among CA-UTI isolates was 0.25% (2/809).

Conclusion: Our study indicated high prevalence of ESBL in strains from strictly defined community-acquired urinary tract infections in adults in China. Imipenem, colistin, ertapenem, amikacin, and nitrofurantoin were the most active antimicrobials against ESBL-positive isolates. is the predominant gene in ESBL-producing and ESBL-uncertain strains. Our study indicated that the use of cephalosporins and fluoroquinolone needs to be restricted for empirical treatment of CA-UTIs in China.
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http://dx.doi.org/10.3389/fmicb.2021.663033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292957PMC
July 2021

Role of breast MRI in predicting histologic upgrade risks in high-risk breast lesions: A review.

Eur J Radiol 2021 Jul 9;142:109855. Epub 2021 Jul 9.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai 200025, China. Electronic address:

Purpose: This article reviews the frequency, upgrade rate and valuable imaging characteristics for predicting the histologic upgrade risks of high-risk lesions on MRI, so as to provide a reference for the management of the lesions.

Methods: A comprehensive search for relevant publications from January 2011 to January 2021 was conducted in the PubMed database. The frequency, upgrade rate and valuable imaging characteristics for predicting the upgrade risks of high-risk lesions on MRI included in the articles were reviewed, and the management of high-risk lesions was provided with a reference according to the review results.

Results And Conclusions: In terms of management options, Atypical ductal hyperplasia (ADH) and Lobular neoplasia (LN) (the top two high-risk lesions with the highest upgrade rate and frequency) were treated with surgical resection. However, the final treatment decision for other high-risk lesions should be made by a multidisciplinary committee. In terms of the value of breast MRI in predicting the upgrade risks of high-risk lesions, the lesions that were confirmed to upgrade after surgery showed some enhancement characteristics, especially for ADH and LN. At the same time, Dynamic contrast-enhanced MRI (DCE-MRI) has a high negative predictive value (NPV) in predicting the upgrade risks of the high-risk lesions, hence misdiagnosis and overtreatment can be reduced. Diffusion-weighted imaging (DWI) and relative apparent diffusion coefficient (rADC) can be used to predict the upgrade risks of the lesions, and the ADC of upgraded lesions is lower than that of non-upgraded lesions. However, these conclusions should be confirmed by further studies.
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http://dx.doi.org/10.1016/j.ejrad.2021.109855DOI Listing
July 2021

Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems.

Molecules 2021 Jul 7;26(14). Epub 2021 Jul 7.

CortecNet, 7 Avenue du Hoggar, 91940 Les Ulis, France.

In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core-shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.
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http://dx.doi.org/10.3390/molecules26144142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306949PMC
July 2021

A Novel Diarylethene-rhodamine Unit Based Chemosensor for Fluorimetric and Colorimetric Detection of Hg.

J Fluoresc 2021 Jul 23. Epub 2021 Jul 23.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, 330013, PR China.

A novel fluorimetric and colorimetric chemosensor (1O) was synthesized with diarylethene-rhodamine unit and characterized by ESI-MS, H NMR, and C NMR. The chemosensor can selectively recognize extremely low concentrations of Hg over a variety of metal ions with remarkable colorimetric and fluorescent responses. The colorimetric and fluorescent changes were ascribed the reaction between 1O and Hg destructed the rhodamine hydrazide into open-ring form which was proved by mass spectrometry and nuclear magnetic titration analyses. The detection limits of the UV absorption and fluorescence methods for Hg were found to be 0.708 μM and 24.6 nM, respectively. Moreover, the chemosensor exhibited excellent photochromism and outstanding fatigue resistance property under alternating UV and visible light irradiation. The application potential of the chemosensor was demonstrated with the qualitative detection of Hg in real water samples.
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http://dx.doi.org/10.1007/s10895-021-02775-4DOI Listing
July 2021

Identification of Potential Signatures and Their Functions for Acute Lymphoblastic Leukemia: A Study Based on the Cancer Genome Atlas.

Front Genet 2021 6;12:656042. Epub 2021 Jul 6.

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objective: Acute lymphoblastic leukemia (ALL) is a malignant disease most commonly diagnosed in adolescents and young adults. This study aimed to explore potential signatures and their functions for ALL.

Methods: Differentially expressed mRNAs (DEmRNAs) and differentially expressed long non-coding RNAs (DElncRNAs) were identified for ALL from The Cancer Genome Atlas (TCGA) and normal control from Genotype-Tissue Expression (GTEx). DElncRNA-microRNA (miRNA) and miRNA-DEmRNA pairs were predicted using online databases. Then, a competing endogenous RNA (ceRNA) network was constructed. Functional enrichment analysis of DEmRNAs in the ceRNA network was performed. Protein-protein interaction (PPI) network was then constructed. Hub genes were identified. DElncRNAs in the ceRNA network were validated using Real-time qPCR.

Results: A total of 2,903 up- and 3,228 downregulated mRNAs and 469 up- and 286 downregulated lncRNAs were identified for ALL. A ceRNA network was constructed for ALL, consisting of 845 lncRNA-miRNA and 395 miRNA-mRNA pairs. These DEmRNAs in the ceRNA network were mainly enriched in ALL-related biological processes and pathways. Ten hub genes were identified, including SMAD3, SMAD7, SMAD5, ZFYVE9, FKBP1A, FZD6, FZD7, LRP6, WNT1, and SFRP1. According to Real-time qPCR, eight lncRNAs including ATP11A-AS1, ITPK1-AS1, ANO1-AS2, CRNDE, MALAT1, CACNA1C-IT3, PWRN1, and WT1-AS were significantly upregulated in ALL bone marrow samples compared to normal samples.

Conclusion: Our results showed the lncRNA expression profiles and constructed ceRNA network in ALL. Furthermore, eight lncRNAs including ATP11A-AS1, ITPK1-AS1, ANO1-AS2, CRNDE, MALAT1, CACNA1C-IT3, PWRN1, and WT1-AS were identified. These results could provide a novel insight into the study of ALL.
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http://dx.doi.org/10.3389/fgene.2021.656042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290159PMC
July 2021

VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.

Sci Rep 2021 Jul 22;11(1):14985. Epub 2021 Jul 22.

Division of Oncology, Gansu Provincial Hospital, 204 Donggang West road, Chengguan district, Lanzhou City, 730000, Gansu Province, China.

Schiff base compounds and their metal complexes have become important synthetic organic drugs due to their extensive biological activities, which include anticancer, antibacterial and antiviral effects. In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced by VALD-3. Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. Western blot analysis revealed that VALD-3 upregulated pro-apoptotic proteins (Bad and Bax), downregulated anti-apoptotic proteins (Bcl-2, Bcl-xl, survivin and XIAP) and increased the expression of cleaved caspase-3, cleaved caspase-8, Cyto-c and cleaved PARP. VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. In addition, survival analysis showed that VALD-3 can significantly prolong the survival time of mice (P = 0.036). This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer.
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http://dx.doi.org/10.1038/s41598-021-94388-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298535PMC
July 2021

Retainable Superconductivity and Structural Transition in 1T-TaSe Under High Pressure.

Inorg Chem 2021 Aug 21;60(15):11385-11393. Epub 2021 Jul 21.

State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, People's Republic of China.

As a prominent platform possessing the properties of superconductivity (SC) and charge density wave (CDW), transition-metal dichalcogenides (TMDCs) have attracted considerable attention for a long time. Moreover, extensive efforts have been devoted for exploring the SC and/or the interplay between SC and CDW in TMDCs in the past few decades. Here, we systematically investigate the electronic properties and structural evolution of 1T-TaSe under pressure. With increasing pressure, pressure-induced superconductivity is observed at ∼2.6 GPa. The superconductive transition temperature () increases with the suppression of the CDW state to the maximum value of ∼5.1 K at 21.8 GPa and then decreases monotonously up to the highest pressure of 57.8 GPa. 1T-TaSe transforms into a monoclinic 2/ structure above 19 GPa. The monoclinic phase coexists with the original phase as the pressure is released under ambient conditions and the retainable superconductivity with = 2.9 K is observed in the released sample. We suggest that the retained superconductivity can be ascribed to the retention of the superconductive high-pressure monoclinic phase in the released sample. Our findings demonstrate that both the structure and CDW order are related to the superconductivity of TaSe.
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http://dx.doi.org/10.1021/acs.inorgchem.1c01378DOI Listing
August 2021

Treatment with Methylphenidate for Attention Deficit Hyperactivity Disorder (ADHD) and the Risk of All-Cause Poisoning in Children and Adolescents: A Self-Controlled Case Series Study.

CNS Drugs 2021 Jul 20;35(7):769-779. Epub 2021 Jul 20.

Department of Pharmacology and Pharmacy, Centre for Safe Medication Practice and Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2/F Laboratory Block, 21 Sassoon Road, Hong Kong, China.

Background: Children and adolescents with attention deficit hyperactivity disorder (ADHD) are at higher risk of all-cause poisoning by drugs and chemicals (intentional or accidental). Currently, there is limited data on whether medication treatment for ADHD can reduce the risk of all-cause poisoning.

Methods: Patients aged 5-18 years with a methylphenidate (MPH) prescription and an incident poisoning diagnosis between January 2001 and June 2020 were identified from the Hong Kong Clinical Data Analysis and Reporting System. A self-controlled case series study design was used to compare the incidence rate ratios (IRRs) of all-cause poisoning during different risk windows (30 days before the first MPH prescription, exposure periods within 30 days of the first prescription, and periods of subsequent exposure) compared with the reference window (other non-exposure periods).

Results: 42,203 patients were prescribed ADHD medication in Hong Kong during the study period. Of these, 417 patients who had both an MPH prescription and poisoning incident recorded were included in the main analysis. Compared with other non-exposed periods, a higher risk of poisoning was found in the 30 days before the first prescription (IRR 2.64, 95% confidence interval [CI] 1.33-5.22) and exposure periods within 30 days of the first prescription (IRR 2.18, 95% CI 1.06-4.48), but not during prolonged exposure. However, compared with 30 days before the first prescription as well as exposure periods within 30 days of the first prescription, there was a lower risk during the subsequent exposure (IRRs 0.49 and 0.60, respectively). Similar results to the main analysis were also found in the subgroup analysis of intentional poisoning and females, but not in that of accidental poisoning and males.

Conclusions: The risk of all-cause poisoning was higher shortly before and after the first MPH prescription and became lower during the subsequent prescription period. Our results do not support an association between the use of MPH and an increased risk of all-cause poisoning in children and adolescents and, in fact, suggest that longer-term use of MPH may be associated with a lower risk of all-cause poisoning, although this latter finding requires further study.
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http://dx.doi.org/10.1007/s40263-021-00824-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310501PMC
July 2021

ZnSe Modified Zinc Metal Anodes: Toward Enhanced Zincophilicity and Ionic Diffusion.

Small 2021 Jul 18:e2101728. Epub 2021 Jul 18.

Pillar of Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.

Zinc metal is an ideal candidate for aqueous rechargeable batteries due to its high theoretical capacity and natural abundance. However, its commercialization is inevitably challenged by several critical factors such as dendrite growth and parasitic side-reactions, leading to low coulombic efficiency and a limited lifespan. Herein, a modified Zn foil with a zincophilic ZnSe layer deposited by a simple selenization process is proposed. An order of magnitude stronger adsorption capability toward Zn ions and uniform ion diffusion tunnels of ZnSe enables lower nucleation energy barrier and faster ion-diffusion kinetics. Meanwhile, detrimental Zn corrosion in aqueous system is also effectively mitigated. As a result, [email protected] anode shows reversible Zn plating/stripping (1700 h at 1 mA cm ) with ultra-low voltage hysteresis (41 mV), contributing to exceptional cycling stability over 500 cycles with negligible capacity fading for the [email protected]/MnO full cell.
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http://dx.doi.org/10.1002/smll.202101728DOI Listing
July 2021

Aspirin Use and Common Cancer Risk: A Meta-Analysis of Cohort Studies and Randomized Controlled Trials.

Front Oncol 2021 18;11:690219. Epub 2021 Jun 18.

School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Whether aspirin use can decrease or increase cancer risk remains controversial. In this study, a meta-analysis of cohort studies and randomized controlled trials (RCTs) were conducted to evaluate the effect of aspirin use on common cancer risk.

Method: Medline and Embase databases were searched to identify relevant studies. Meta-analyses of cohort studies and RCTs were performed to assess the effect of aspirin use on the risk of colorectal, gastric, breast, prostate and lung cancer. Cochran Q test and the I square metric were calculated to detect potential heterogeneity among studies. Subgroup meta-analyses according to exposure categories (frequency and duration) and timing of aspirin use (whether aspirin was used before and after cancer diagnosis) were also performed. A dose-response analysis was carried out to evaluate and quantify the association between aspirin dose and cancer risk.

Results: A total of 88 cohort studies and seven RCTs were included in the final analysis. Meta-analyses of cohort studies revealed that regular aspirin use reduced the risk of colorectal cancer (CRC) (RR=0.85, 95%CI: 0.78-0.92), gastric cancer (RR=0.67, 95%CI: 0.52-0.87), breast cancer (RR=0.93, 95%CI: 0.87-0.99) and prostate cancer (RR=0.92, 95%CI: 0.86-0.98), but showed no association with lung cancer risk. Additionally, meta-analyses of RCTs showed that aspirin use had a protective effect on CRC risk (OR=0.74, 95%CI: 0.56-0.97). When combining evidence from meta-analyses of cohorts and RCTs, consistent evidence was found for the protective effect of aspirin use on CRC risk. Subgroup analysis showed that high frequency aspirin use was associated with increased lung cancer risk (RR=1.05, 95%CI: 1.01-1.09). Dose-response analysis revealed that high-dose aspirin use may increase prostate cancer risk.

Conclusions: This study provides evidence for low-dose aspirin use for the prevention of CRC, but not other common cancers. High frequency or high dose use of aspirin should be prescribed with caution because of their associations with increased lung and prostate cancer risk, respectively. Further studies are warranted to validate these findings and to find the minimum effective dose required for cancer prevention.
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http://dx.doi.org/10.3389/fonc.2021.690219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279749PMC
June 2021

Bacterial alginate metabolism: an important pathway for bioconversion of brown algae.

Biotechnol Biofuels 2021 Jul 18;14(1):158. Epub 2021 Jul 18.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.

Brown macroalgae have attracted great attention as an alternative feedstock for biorefining. Although direct conversion of ethanol from alginates (major components of brown macroalgae cell walls) is not amenable for industrial production, significant progress has been made not only on enzymes involved in alginate degradation, but also on metabolic pathways for biorefining at the laboratory level. In this article, we summarise recent advances on four aspects: alginate, alginate lyases, different alginate-degrading systems, and application of alginate lyases and associated pathways. This knowledge will likely inspire sustainable solutions for further application of both alginate lyases and their associated pathways.
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http://dx.doi.org/10.1186/s13068-021-02007-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286568PMC
July 2021

Methodology in phenome-wide association studies: a systematic review.

J Med Genet 2021 Jul 16. Epub 2021 Jul 16.

School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Phenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims to summarise the PheWAS methodology, discuss the advantages and challenges of PheWAS, and provide potential implications for future PheWAS studies. Medical Literature Analysis and Retrieval System Online (MEDLINE) and Excerpta Medica Database (EMBASE) databases were searched to identify all published PheWAS studies up until 24 April 2021. The PheWAS methodology incorporating how to perform PheWAS analysis and which software/tool could be used, were summarised based on the extracted information. A total of 1035 studies were identified and 195 eligible articles were finally included. Among them, 137 (77.0%) contained 10 000 or more study participants, 164 (92.1%) defined the phenome based on electronic medical records data, 140 (78.7%) used genetic variants as predictors, and 73 (41.0%) conducted replication analysis to validate PheWAS findings and almost all of them (94.5%) received consistent results. The methodology applied in these PheWAS studies was dissected into several critical steps, including quality control of the phenome, selecting predictors, phenotyping, statistical analysis, interpretation and visualisation of PheWAS results, and the workflow for performing a PheWAS was established with detailed instructions on each step. This study provides a comprehensive overview of PheWAS methodology to help practitioners achieve a better understanding of the PheWAS design, to detect understudied or overstudied outcomes, and to direct their research by applying the most appropriate software and online tools for their study data structure.
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http://dx.doi.org/10.1136/jmedgenet-2021-107696DOI Listing
July 2021

Carbapenemase detection by NG-Test CARBA 5-a rapid immunochromatographic assay in carbapenem-resistant diagnosis.

Ann Transl Med 2021 May;9(9):769

Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The global spread of carbapenem-resistant (CRE) represents a serious public health concern as these organisms are associated with limited treatment options, high mortality rate and rapid transmissibility. The identification of carbapenemase remains a challenge in microbiological laboratories as no single method is perfect when considering cost, carbapenemase coverage, accuracy, handling complexity and TATs together.

Methods: NG-Test CARBA 5 assay and modified carbapenem inactivation method in conjunction with EDTA carbapenem inactivation method (mCIM/eCIM) were challenged with a collection of 299 molecularly characterized CRE isolates in China in order to evaluate the performance in detecting five major carbapenemases ( , , , , and ) among Enterobacterales.

Results: NG-Test CARBA 5 detected all KPC-, NDM-, VIM- and OXA-48-producing isolates perfectly with a weak false-positive signal for NDM in an IMP-4 producer, which makes the specificity for NDM decreases to 99.6%. The overall specificity/sensitivity were 99.9%/100% for NG-Test CARBA 5. mCIM/eCIM achieved high specificity of 100%/100% and sensitivity of 99.6%/97.4%, with one S. marcescens isolate harboring VIM-2 undetected.

Conclusions: Both NG-Test CARBA 5 and mCIM/eCIM showed excellent results in the tested carbapenemase ( , , , , and ) detection compared with molecular genotypic test. As every assay has its own limitations, suitable methods should be combined for the establishment of the CRE diagnostic pathways.
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http://dx.doi.org/10.21037/atm-20-8216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246204PMC
May 2021

Pericardial tamponade after chronic total occlusion revascularization: a case report and literature review.

Ann Palliat Med 2021 Jul 7. Epub 2021 Jul 7.

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Pericardial tamponade is a complication of percutaneous coronary intervention (PCI) with extremely high mortality. The rupture of coronary artery causes hypotension and shock, eventually resulting in death due to pericardial tamponade. Because of the complex operation in revascularization of chronic total occlusion (CTO-PCI) lesion, the incidence of pericardial tamponade increases. Usually, we use coronary angiogram to identify the rupture of coronary artery after PCI by the contrast agent. We presented a 67-year-old woman with pericardial tamponade after CTO revascularization. She had chest pain and out of breath for nearly two years. The coronary angiogram showed three branch lesion and CTO lesion of the right coronary artery (RCA). After revascularization of the RCA CTO lesion, the pericardial effusion and low blood pressure occurred, but we didn't find the leak of contrast agents during the final angiography. Then the patient was transferred to cardiac surgery department for emergency thoracotomy. They found the hematoma on the surface of the RCA and finally discharged without any symptoms. Our case approved: (I) there was still the possibility of coronary artery rupture even the coronary angiogram showed no contrast agent leakage from the coronary artery after PCI; (II) the combined use of IVUS and coronary angiogram may improve the accuracy and safety of CTO revascularization procedure.
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http://dx.doi.org/10.21037/apm-20-2455DOI Listing
July 2021

Effect of nanoprocessing on the physicochemical properties of bovine, porcine, chicken, and rabbit bone powders.

Food Sci Nutr 2021 Jul 18;9(7):3580-3592. Epub 2021 May 18.

College of Food Science Southwest University Chongqing China.

The chemical composition and hardness of bovine bone, porcine bone, chicken bone, and rabbit bone were compared, as well as the influence of nanoprocessing on the physicochemical characteristics of these bone powders. A series of nanofabrication processes led to an increase in bone minerals and the loss of protein and fat. The hardness of softened bovine bone was still the largest, whereas chicken and rabbit bones were relatively soft. There were no significant differences in the functional groups between nanoscale bone powders. Overall, nanomachining significantly reduced and homogenized the bone particle size and improved the color and release rate of calcium ions of bone powders at the same time; these effects were different for several bones. Nanoscale rabbit bone had higher comminution efficiency, as well as satisfactory nutritional value, color, and product yield, which supports its strong development potential.
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http://dx.doi.org/10.1002/fsn3.2312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269694PMC
July 2021

Snake extract-laden hemostatic bioadhesive gel cross-linked by visible light.

Sci Adv 2021 Jul 14;7(29). Epub 2021 Jul 14.

Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China.

Bioadhesives reduce operation time and surgical complications. However, in the presence of blood, adhesion strength is often compromised. Inspired by the blood clotting activity of snake venom, we report a visible light-induced blood-resistant hemostatic adhesive (HAD) containing gelatin methacryloyl and reptilase, which is a hemocoagulase (HC) extracted from HAD leads to the activation and aggregation of platelets and efficiently transforms fibrinogen into fibrin to achieve rapid hemostasis and seal the tissue. Blood clotting time with HAD was about 45 s compared with 5 to 6 min without HAD. HAD instantaneously achieved hemostasis on liver incision (~45 s) and cut rat tail (~34 s) and reduced blood loss by 79 and 78%, respectively. HAD is also efficient in sealing severely injured liver and abdominal aorta. HAD has great potential to bridge injured tissues by combing hemostasis with adhesives.
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http://dx.doi.org/10.1126/sciadv.abf9635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279511PMC
July 2021

Selective reduction of nitrate to ammonium over charcoal electrode derived from natural wood.

Chemosphere 2021 Jul 9;285:131501. Epub 2021 Jul 9.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian, 116024, China. Electronic address:

Electrocatalytic nitrate reduction has been regarded as an efficient alternative route for ammonia production. Developing efficient, economical and environment-friendly cathodes is a significant concern for the practical applications of this method. Herein, we report a charcoal electrode fabricated by carbonizing natural wood for efficient nitrate reduction. It displays high overpotential for hydrogen evolution, moderate sp C structure and oxygen-containing surface groups. Benefiting from these features, the charcoal cathode exhibits high nitrate removal rate (91.2%), outstanding selectivity (98.5%) and fast production rate (0.570 mmol L h cm) for ammonium. Both removal rate and selectivity are superior to other carbon materials and comparable to metal-containing cathodes. These results exhibit the possibility of using charcoal as cathodes for denitrification and ammonia recovery from wastewater.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131501DOI Listing
July 2021

Rapid simultaneous removal of cationic dyes and Cr(VI) by boron cluster polyaniline with a target site.

Chem Commun (Camb) 2021 Jul;57(61):7569-7572

Institute for Ecological Research and Pollution Control of Plateau Lakes, School of Ecology and Environmental Science, Yunnan University, Kunming 650504, P. R. China.

The stable physicochemical properties of polyaniline/closo-[B12H12]2- (PA/B12) obtained by an ion exchange technique combined with polyaniline (PA) and closo-[B12H12]2- (B12) can realize rapid kinetic adsorption and complete removal of Cr(vi) and cationic dye pollutants at low concentrations. The reversible adsorption/desorption process of pollutants represents that PA/B12 has practical industrial use value.
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http://dx.doi.org/10.1039/d1cc03140fDOI Listing
July 2021

Site-specific internal protein labeling through trans-splicing.

Int J Biol Macromol 2021 Jul 5;186:40-46. Epub 2021 Jul 5.

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China. Electronic address:

Atypical S1 and S11 split inteins have been used for N-terminal or C-terminal protein labeling. Here we reported a novel site-specific internal protein labeling method based on two atypical split inteins, Ter DnaE3 S11 and Rma DnaB S1. Protein-peptide trans-splicing activity was first demonstrated in vitro between a short peptide (Flag tag, FLAG) and two recombinant proteins (Maltose binding protein, MBP, and Thioredoxin, Trx) by trans-splicing between MBP-TE3S11N (MBP-N fragment of Ter DnaE3 S11), TE3S11C-FLAG-RBS1N (C fragment of Ter DnaE3 S11-FLAG-N fragment of Rma DnaB S1), and RBS1C-Trx (C fragment of Rma DnaB S1-Trx). To minimize the middle synthetic peptide (TE3S11C-linker-RBS1N), we reduced the number of native extein amino acids, which may play a role in protein trans-splicing. The results showed at least 3 (CKG) native extein amino acids were required for detectable trans-splicing activity. This method was further demonstrated to be effective in facilitating the incorporation of fluorescent probe (FITC) to the internal site of recombinant protein, generating the FITC-labeled protein. Besides the fluorescent group, these two split inteins can also be useful for adding any desirable chemical groups into a protein of interest, which may include biotin, modified and unnatural amino acids, or drug molecules.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.07.009DOI Listing
July 2021

Effect of Trimethyltin chloride on proliferation and cell cycle of intestinal porcine epithelial cells.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jul 8;249:109131. Epub 2021 Jul 8.

Department of Basic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China. Electronic address:

Trimethyltin chloride (TMT) is a highly toxic substance produced by organotin heat stabilizers in the synthesis of polyvinyl chloride (PVC) products. TMT is widely used in industry and agriculture. The aim of this study was to investigate the effects of TMT-induced cytotoxicity in intestinal porcine epithelial cells (IPEC-J2). Our study showed that TMT induced a decline in cell viability of IPEC-J2, caused cell shrinkage and rounded cell morphology, reduced the number of proliferating cells and the expression of proliferating cell nuclear antigen (PCNA), and increased lactate dehydrogenase (LDH) activity in cell supernatants. Simultaneously, TMT lowered the mRNA expression of Cyclin B1, and Cyclin D1, but increased P21 and P27 expression. The cell cycle progression was arrested from the G1 to the S phase. Furthermore, the mRNA expression of Bax/Bcl-2 ratio and the protein expression of cleaved Caspase-9 and cleaved Caspase-3 were significantly increased after TMT treatment, while the ratio of advanced apoptotic cells was elevated. These results indicated that TMT blocked the cell cycle, inhibited IPEC-J2 proliferation, and induced apoptosis.
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http://dx.doi.org/10.1016/j.cbpc.2021.109131DOI Listing
July 2021

Decisional control preference among Chinese patients with advanced kidney disease: the role of mastery, perceived social support and self-efficacy.

Psychol Health Med 2021 Jul 9:1-12. Epub 2021 Jul 9.

School of Nursing and Health, Zhengzhou University, Zhengzhou, China.

Although previous studies have shown a correlation between mastery, self-efficacy, and perceived social support among Chinese patients with advanced kidney disease, few studies have examined their relationship pathways. This study aimed to examine decisional control preference and the relationship between mastery, perceived social support, and self-efficacy among patients with advanced chronic kidney disease. A cross-sectional survey was conducted, and 350 participants were investigated using Control Preference Scale, Personal Mastery Scale, Perceived Social Support Scale, and Self-efficacy Scale. The mediating relationships were determined via structural equation modeling. Results showed that education and economic status were demographic factors influencing patients' decisional control preference. The model showed that mastery and self-efficacy had a direct effect on decisional control preference while perceived social support had an indirect effect mediated via mastery and self-efficacy. Therefore, improving self-efficacy can increase patient willingness to involve in medical decision-making. This study provides new interventions and future directions for promoting decisional control preference.
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http://dx.doi.org/10.1080/13548506.2021.1952282DOI Listing
July 2021
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