Publications by authors named "Xubin Zhang"

18 Publications

  • Page 1 of 1

DINs: Deep Interactive Networks for Neurofibroma Segmentation in Neurofibromatosis Type 1 on Whole-Body MRI.

IEEE J Biomed Health Inform 2021 Jun 9;PP. Epub 2021 Jun 9.

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that involves the central and peripheral nervous systems. Accurate detection and segmentation of neurofibromas are essential for assessing tumor burden and longitudinal tumor size changes. Automatic convolutional neural networks (CNNs) are sensitive and vulnerable as tumors' variable anatomical location and heterogeneous appearance on MRI. In this study, we propose deep interactive networks (DINs) to address the above limitations. User interactions guide the model to recognize complicated tumors and quickly adapt to heterogeneous tumors. We introduce a simple but effective Exponential Distance Transform (ExpDT) that converts user interactions into guide maps regarded as the spatial and appearance prior. Comparing with popular Euclidean and geodesic distances, ExpDT is more robust to various image sizes, which reserves the distribution of interactive inputs. Furthermore, to enhance the tumor-related features, we design a deep interactive module to propagate the guides into deeper layers. We train and evaluate DINs on three MRI data sets from NF1 patients. The experiment results yield significant improvements of 44% and 14% in DSC comparing with automated and other interactive methods, respectively. We also experimentally demonstrate the efficiency of DINs in reducing user burden when comparing with conventional interactive methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2021.3087735DOI Listing
June 2021

Core-shell NiSe/Ni(OH)with NiSe nanorods and Ni(OH)nanosheets as battery-type electrode for hybrid supercapacitors.

Nanotechnology 2021 Jun 4;32(34). Epub 2021 Jun 4.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, People's Republic of China.

Novel core-shell nanostructure electrodes benefit from the excellent properties of their constituent materials, as well as the synergy between them. However, it is challenging to fabricate such structures efficiently. In this study, NiSe nanorods were fabricated using Ni foam as the conductive substrate and reactant via a one-step hydrothermal process, and Ni(OH)nanosheets were coated on the surface of the nanorods via one-step electrodeposition. The effect of the structure and morphology on the properties of the material was explored using scanning electron microscopy, x-ray diffraction, and electrochemical technology. The obtained core-shell NiSe/Ni(OH)exhibited an areal capacity of 1.89 mAh cmat a current density of 5 mA cm. The assembled NiSe/Ni(OH)//AC hybrid supercapacitor exhibited excellent energy and power densities, indicating that NiSe/Ni(OH)has great potential for use as a battery-type electrode in energy storage systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ac02eaDOI Listing
June 2021

Racing Crystallization Mechanism for Economical Design of Single-Crystal Hollow ZSM-5 with the Broken Limit of Si/Al Ratio and Improved Mass Transfer.

ACS Appl Mater Interfaces 2021 Apr 29;13(13):15246-15260. Epub 2021 Mar 29.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P.R. China.

Development of economic strategy to synthesize hollow zeolite with widely tunable Si/Al ratios providing variable acidity is of great significance in industry. Here, a one-step and low-cost strategy without mesoporogen was successfully developed to synthesize single-crystal hollow ZSM-5 containing mesopores/macropores, with variable Si/Al ratios of about 14-∞ and 114-∞ at critical TPA/SiO ratios of 0.05-0.1 and 0.05, respectively. This is the first time the usage of a large amount of TPAOH was avoided while breaking the traditional limitation of Si/Al ratio (25-50). The component of synthesis system and crystallization temperature acting as the vital roles in hollow structure has been confirmed by a series of characterization. Moreover, according to the investigation of the evolution process, a novel racing crystallization mechanism based on the competition relationship between surface crystallization and the internal dissolution rate was proposed for the first time. The racing crystallization mechanism and internal nonprotective aluminum become the crucial factors for synthesis. The prepared hollow ZSM-5 zeolites exhibit superior catalytic performance in the different acidity-catalyzed condensation involving large molecules between benzaldehyde and -butyl alcohol as well as 2-hydroxyacetophenone, which is mainly attributed to the property acidity, more accessible active Al sites on the surface, and shorter diffusion path. By calculating, the effectiveness factor (η) of hollow zeolite is close to 1, further confirming its better mass transfer ability. The strategy has also been successfully extended to the synthesis of high-amount Fe-doped, Ga-doped, and B-doped hollow silicate-1.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.1c00768DOI Listing
April 2021

Gonadal development and biochemical composition of Chinese mitten crabs (Eriocheir sinensis) from four sources.

J Food Sci 2021 Mar 18;86(3):1066-1080. Epub 2021 Feb 18.

National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.

The gonadal development; edible tissue ratio; and proximate, fatty acid, and free amino acid composition were examined and compared among Eriocheir sinensis samples from four sources. The gonadosomatic index (GSI) of Heilongjiang (HLJ) crabs was significantly higher than that of the other crabs from September to October (P < 0.05). Of all the edible tissues of E. sinensis, HLJ crab had the highest linolenic acid (18:3n3, LNA) and arachidonic acid (20:4n6, ARA) contents (P < 0.05), while Qinghai (QH) crab had the highest eicosapentaenoic acid (20:5n3, EPA) content (P < 0.05). The highest docosahexaenoic acid (22:6n3, DHA) and DHA/EPA contents were observed in Shandong (SD) crabs (P < 0.05), and the highest linoleic acid (18:2n6, LA) content was found in Shanghai (SH) crabs (P < 0.05). In conclusion, E. sinensis inhabiting relatively low-temperature regions (northern China) can initiate gonadal development earlier, and the quality of E. sinensis living in paddies and lakes is better than that of crabs living in ponds.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.15647DOI Listing
March 2021

Regulating the core/shell electric structure of [email protected] layered double hydroxide on Ni foam through electrodeposition for a quasi-solid-state supercapacitor.

Nanotechnology 2021 May 31;32(34). Epub 2021 May 31.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, People's Republic of China.

A flower-like structured electrode material of [email protected] layered double hydroxide (LDH) grown on Ni foam ([email protected] LDH/NF) was prepared via angrowth, annealing and electrodeposition process. The [email protected] LDH/NF electrode was prepared with the optimized conditions of annealing temperature 300 °C, deposition time 20 min and Ni/Co ratio 1:1. The results showed that the as-prepared electrode material exhibited an excellent specific capacitance and great cycling stability. Furthermore, an quasi-solid-state supercapacitor was assembled using the prepared [email protected] LDH/NF as the positive electrode and activated carbon on Ni foam (AC/NF) as the negative electrode. The as-assembled device presented a high energy density and power density.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/abe074DOI Listing
May 2021

Indirubin-3'-Oxime (IDR3O) Inhibits Proliferation of Osteosarcoma Cells in vitro and Tumor Growth in vivo Through AMPK-Activation and PGC-1α/TFAM Up-Regulation.

Dokl Biochem Biophys 2020 Nov 25;495(1):354-360. Epub 2020 Dec 25.

Department of Traumatology, Dezhou People's Hospital, 253000, Dezhou, China.

Osteosarcoma, a malignant tumor of bones, has very high incidence in adolescents and young people. The present study investigated the effect of indirubin-3'-oxime (IDR3O) derivative on proliferation of osteosarcoma cells in vitro and tumor growth in vivo. Changes in growth and induction of apoptosis in osteosarcoma cells were assessed using WST-8 and TUNEL staining assays. Treatment of MG63 and Saos‑2 cells with IDR3O inhibited proliferation, activated apoptosis and promoted AMPK-activation. In IDR3O treated MG63 and Saos‑2 cells PGC-1α (Peroxisome proliferator-activated receptor-γ coactivator-1α) levels were markedly promoted compared to control (untreated) cells. In the mice model osteosarcoma was induced by implantation of 2 × 10 MG63 cells on dorsal side subcutaneously. Then the experimental group of mice received IDR3O intra-peritoneally during 45 days. IDR3O-treatment suppressed tumor development significantly compared to control (untreated) group but didn't changed body weight. IDR3O inhibits osteosarcoma cell growth and activates apoptosis through AMPK dependent pathway. Therefore, IDR3O may be considered for treatment of osteosarcoma as it effectively arrests tumor growth in mice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1134/S1607672920060022DOI Listing
November 2020

MOF-derived [email protected]@PPy core-shell nanosheets on Ni foam for high-performance supercapacitors.

Nanotechnology 2021 Apr;32(14):145404

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, People's Republic of China.

The [email protected]@PPy core-shell nanosheets material is prepared by directly growing leaf-like ZnCoO nanosheets derived from the metal-organic framework (MOF) on Ni foam (NiF) via chemical bath deposition and annealing methods and then combining with NiCoS and PPy via electrodeposition methods. The special core-shell structure formed by MOF-derived ZnCoO, NiCoS and PPy creates a bi-interface, which could significantly promote the contact between electrode and electrolyte, provide more active sites and accelerate electron/ion transfer. And the combination of these three materials also produces a strong synergistic effect, which could further improve the capacitive performance of the electrode. Therefore, the [email protected]@PPy/NiF electrode exhibits the maximum areal capacitance (3.75 F cm) and specific capacitance (2507.0 F g) at 1 mA cm and 0.5 A g, respectively. Moreover, its capacitance retention rate is still 83.2% after 5000 cycles. In addition, a coin-type hybrid supercapacitor is assembled and displays a high energy density of 44.15 Wh kg and good cycling performance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/abd20bDOI Listing
April 2021

COVID-19 outbreak prevention by early containment in Shantou, China.

J Infect Dev Ctries 2020 Jul 31;14(7):742-747. Epub 2020 Jul 31.

Center of Diseases Control and Prevention in Shantou, Shantou, China.

Introduction: To report about the successful outbreak containment of COVID-19 in Shantou, one of the prefectural cities of Guangdong province in the mainland China.

Methodology: All patients confirmed as having COVID-19 between 23 January and 25 March 2020 by RT-PCR assay in the clinical lab of Shantou CDC were included and divided into three groups based on the source of identification: hospital diagnosis, contact tracing, and community screening. Collected data was analyzed and compared among these three groups.

Results: A total of 25 COVID-19 cases were identified in Shantou. The first case was identified on 14 January 2020 at one of two COVID-19 dedicated hospitals in Shantou. The majority of the cases were either imported from Wuhan or linked to Wuhan/Hubei. The median lag time for diagnosis (i.e., the time between symptom onset and case confirmation) was 2 days (IQR, 2.0-4.0) for all cases, 9 days (IQR, 7.0-10.0) for the cases diagnosed in hospitals, 2 days (IQR, 1.5-2.0) for the cases in contact tracing, and 4 days (IQR, 2.5-4.5) for cases in community screening, with a significantly longer diagnosis lag time in hospitals (p = 0.003). Multivariate linear regression models showed larger family size and severe cases as the significant predictor for increasing number of close contacts.

Conclusions: The current pandemic appears to exist for an uncertain period. The early containment measures applied in Shantou, a city with insufficient healthcare resources for COVID-19, seems to be appropriate for cities or areas with similar profiles.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3855/jidc.13121DOI Listing
July 2020

Multifunctional gene delivery systems with targeting ligand CAGW and charge reversal function for enhanced angiogenesis.

J Mater Chem B 2019 03 15;7(11):1906-1919. Epub 2019 Feb 15.

School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin 300350, China.

Gene delivery systems with good biocompatibility and high transfection efficiency play a major role in the clinical application of gene therapy. It is of great interest to develop a functional anionic polymer to modify polycationic carriers for the purpose of improving their biocompatibility and gene delivery ability. Herein, we prepared three kinds of anionic polymers, i.e., cis-aconitic anhydride grafted poly(l-lysine) (PLCA), cis-aconitic anhydride and CAGW functional peptide grafted poly(l-lysine) (PLCA-CAGW), and succinic anhydride and CAGW peptide grafted poly(l-lysine) (PLSA-CAGW), and coated them onto binary gene complexes to obtain three ternary complexes, i.e., TCP-CA, TCP-CA-CAGW and TCP-SA-CAGW, respectively. These gene delivery systems were integrated with a specific functional peptide and smart polyplexes that enabled them to perform a desired function in response to pH changes in biological microenvironments. The results of the cell viability assay showed that the prepared anionic polymers could improve the biocompatibility of gene complexes. Gene expression at the mRNA and protein levels demonstrated that TCP-CA-CAGW enhanced the gene delivery efficiency, benefiting from the targeting CAGW peptide and charge reversal moiety (cis-aconitic amide), while TCP-SA-CAGW showed a relatively low transfection efficiency because of negatively charged PLSA-CAGW and its non-reversal function. The PLCA-CAGW shell in TCP-CA-CAGW possessed an aconitic acid group, EC targeting ligand and charge reversal cis-aconitic amide, which enabled the gene delivery systems to be neutral in blood circulation, but once in the acidic lysosomes, they became positively charged for improving lysosomal escape and nuclear localization. Importantly, the in vitro/vivo angiogenesis assay demonstrated that human umbilical vein endothelial cells transfected with TCP-CA-CAGW functionalized ternary complexes could obviously enhance vascularization. These multifunctional ternary complexes with functional smart anionic polymer shells possessed low cytotoxicity and high gene delivery efficiency, and this strategy may be a promising platform for cardiovascular gene therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8tb03085eDOI Listing
March 2019

The diquaternary ammonium surfactant-directed synthesis of single-unit-cell nanowires of ZSM-5 zeolite.

Nanoscale 2020 Mar;12(10):5824-5828

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, Jiangsu, PR China.

Hierarchical ultrathin ZSM-5 zeolite samples with controllable crystal growth directions were realized by designing bifunctional soft templates with different hydrophobic alkyl chain groups. MFI-type crystal growth along the a-c plane and stacking along the b-axis could be controlled to form nanowires of ZSM-5, which exhibited better catalytic activity for phenol hydroxylation than nanosheets of ZSM-5.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0nr00424cDOI Listing
March 2020

Flexible 3D core-shell nanoforest arrays trimetal electrode for high capacitance supercapacitor.

Nanotechnology 2020 May 17;31(22):225603. Epub 2020 Feb 17.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, People's Republic of China.

A supercapacitor electrode with high capacitance is mainly based on the careful design of nanostructures and the intelligent hybridization of custom active materials. Herein, we designed 3D core-shell nanoforest arrays with hierarchical structure which are directly grown on carbon cloth using a two-step bracket-hydrothermal method and electrodeposition process. Due to the advantages of large specific surface area, abundant pores and active sites, the structure of Mo-Co-Ni(nanotube)@Ni-Co(nanosheet) arrays can promote electrolyte penetration and ions diffusion, further improving the electrochemical performance. The 3D core-shell nanoforest arrays electrode shows outstanding electrochemical performance: a superb areal capacitance of 9.81 F cm (1998.0 F g) at the current densities of 1 mA cm, as well as long cycle stability (after 3000 cycles maintains 85.4% of the highest capacitance value). This work may provide a promising method for design of flexible supercapacitor electrode materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab76f4DOI Listing
May 2020

Framework Fe-Doped Mobil Five (MFI) Zeolites as Highly Active and Stable Fenton-Like Catalysts for Basic Dyes Degradation.

J Nanosci Nanotechnol 2020 Mar;20(3):1520-1529

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.

Highly active and stable framework Fe-doped ZSM-5 (f-Fe-ZSM-5) zeolites with different Fe contents, which were synthesized using a facile one-pot hydrothermal method, could effectively resolve the loss of iron element during the catalytic degradation of basic dyes. The successful introduction of Fe species into the framework of ZSM-5 was confirmed by elemental mappings, Fourier transform infrared (FT-IR) spectroscopy and Ultraviolet-visible spectroscopy (UV-vis spectra). The operational parameters, such as Fe content, H₂O₂ concentration, reaction temperature, types of dyes as well as the stability of the synthesized samples were extensively evaluated. It was demonstrated that the f-Fe(0.10)-ZSM-5 exhibited an efficient catalytic ability and excellent stability even after seven consecutive runs. The degradation efficiency of f-Fe-ZSM-5 for basic dyes was higher than that for acid dye. Therefore, f-Fe-ZSM-5 zeolites may present major potential for the treatment of basic dyes waste water without adjusting the initial pH value.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1166/jnn.2020.16947DOI Listing
March 2020

The epidemic characteristics and spatial autocorrelation analysis of hand, foot and mouth disease from 2010 to 2015 in Shantou, Guangdong, China.

BMC Public Health 2019 Jul 24;19(1):998. Epub 2019 Jul 24.

Shantou Center for Disease Control and Prevention, 58 Shanfen road, Shantou, 515041, China.

Background: Hand, foot and mouth disease (HFMD) is the highest incidence of infectious diseases in China. Shantou is one of the most infected cities. Therefore, it is necessary for us to understand the epidemic characteristics and distribution trend of HFMD in Shantou. The purpose of this study is to investigate the spatial epidemiological characteristics of HFMD and analyse its spatial autocorrelation.

Method: We collated and summarised the data of HFMD in Shantou from 2010 to 2015. SaTScan software and Moran's I were used to analyse the spatial correlation of HFMD, and the results were presented in ArcMap.

Results: The distribution of HFMD in Shantou was of a seasonal trend, mainly concentrating during May and June. Children under 5-years-old were the main group of cases of HFMD, accounting for 92.46%. The proportion of infected children, especially those aged zero to 1, was the largest in each year, accounting for 45.62%, meaning that smaller children were more susceptible to HFMD. The number of male patients with HFMD was greater than that of females (1.78:1, male: female). With regard to the potential impact of patients' living style on the incidence rate of HFMD, this study revealed that scattered children were the dominant infected population, accounting for as much 84.49% of cases. The incidence of HFMD was unevenly distributed among streets. The incidence interval of streets was in a range of 13.76/100,000 to 1135.19/100,000. Spatial autocorrelation analysis showed that there was no global spatial correlation in Shantou, except in 2013. The results of local spatial autocorrelation analysis showed that H-H correlation existed in the high incidence local area of Shantou.

Conclusions: The incidence of HFMD across the various streets in Shantou not only varied widely but also represented local autocorrelation. Attention, as well as prevention and control measures, should be focused on those high-incidence areas, such as the Queshi street, Zhuchi street and Xinjin street.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-019-7329-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657152PMC
July 2019

One-pot synthesis of framework W-doped TS-1 zeolite with robust Lewis acidity for effective oxidative desulfurization.

Chem Commun (Camb) 2019 Apr;55(33):4885-4888

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.

Framework W-doped TS-1 zeolite synthesized via a one-pot hydrothermal synthesis displayed more Lewis acid active sites as well as a larger external surface area, and accordingly a better catalytic performance in oxidative desulfurization reactions in comparison to W-MFI and Ti-MFI zeolite catalysts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc00715fDOI Listing
April 2019

The application of meteorological data and search index data in improving the prediction of HFMD: A study of two cities in Guangdong Province, China.

Sci Total Environ 2019 Feb 23;652:1013-1021. Epub 2018 Oct 23.

Injury Prevention Research Center, Shantou University Medical College, Shantou, Guangdong 515041, China. Electronic address:

Hand, foot and mouth disease (HFMD) is a public health issue in China, and its incidence in Guangdong Province is higher than the national average. Previous studies have found climatic factors have an influential role in the transmission of HFMD. Internet search technology has been shown to predict some infectious disease epidemics and is a potential resource in tracking epidemics in countries where the use of Internet search index data is prevalent. This study aims to improve the prediction of HFMD in two Chinese cities, Shantou and Shenzhen in Guangdong Province, applying both meteorological data and Baidu search indices to create a HFMD forecasting model. To this end, the relationship between meteorological factors and HFMD was found to be linear in both cities, while the relationship between search engine data and HFMD was not consistent. The results of our study suggest that using both Internet search and meteorological data can improve the prediction of HFMD incidence. Using comparative analysis of both cities, we posit that improved quality search indices enhance prediction of HFMD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2018.10.304DOI Listing
February 2019

Surface-Active Hollow Titanosilicate Particles as a Pickering Interfacial Catalyst for Liquid-Phase Alkene Epoxidation Reactions.

Langmuir 2018 01 27;34(1):302-310. Epub 2017 Dec 27.

School of Mathematics and Physical Sciences, University of Hull , Hull HU6 7RX, U.K.

The design of catalyst particles bearing excellent catalytic activity and suitable surface wettability is the key to successful application of Pickering interfacial catalysis. In this study, the epoxidation of 1-hexene and cyclohexene with aqueous hydrogen peroxide over hollow TS-1 (HTS-1) zeolite was studied as a probe reaction to investigate the influence of catalyst surface wettability on catalytic activity. Hydrophobized HTS-1 particles were fabricated via a postsynthesis desilication treatment with tetrapropylammonium hydroxide and a postsynthesis silylation treatment with hexamethyldisiloxane (HMDSO). The successful preparation of HTS-1 particles was verified by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy. X-ray diffraction patterns and ultraviolet-visible spectra confirmed that the hydrophobic modification had no effect on the zeolite structure of HTS-1 particles. Stable Pickering emulsions of aqueous hydrogen peroxide in either 1-hexene or cyclohexene could be prepared using HTS-1 particles as emulsifiers and confirmed by cryo-SEM images. The catalytic behavior in the obtained Pickering emulsions revealed a parabolic distribution of turnover frequency values with respect to the hydrophobization degrees with 0.2-HMDSO/HTS-1 particles possessing the maximum values of 20.6 h for 1-hexene epoxidation and 8.1 h for cyclohexene epoxidation. In addition, these 0.2-HMDSO/HTS-1 particles showed good reusability for more than five cycles.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.7b03633DOI Listing
January 2018

Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats.

Mol Med Rep 2015 Aug 7;12(2):3095-100. Epub 2015 May 7.

Department of Orthopedics, Dezhou People's Hospital, Dezhou, Shandong 253045, P.R. China.

Postoperative cognitive dysfunction (POCD), commonly observed in elderly patients, is characterized by impaired concentration, memory and learning following surgery, and may persist for a long duration or progress into serious central nervous system diseases. It has been demonstrated neuroinflammation caused by surgery is involved in the development of POCD. However, the detailed molecular mechanism remains to be fully elucidated. The present study aimed to reveal the role of tumor necrosis factor (TNF)-α in the development of POCD in aged rats. Laparotomy was performed to mimic human abdominal surgery in the aged rats. Following surgery, the memory and learning functions were impaired, with significant upregulation of pro-inflammatory cytokines, including TNF-α, interleukin (IL)-1β, IL-4 and IL-6 in the hippocampal tissues. However, intracisternal administration of the TNF-α receptor antagonist, R-7050, during surgery attenuated these defects in cognitive function and inhibited the production of the pro-inflammatory cytokines in the hippocampal tissues. Furthermore, intracisternal administration of R-7050 inhibited the activation of the downstream nuclear factor-κB and mitogen-activated protein kinase signaling pathway in the hippocampal tissues. Therefore, the results of the present study suggested a key role of the TNF-α-mediated signaling pathway in the development of POCD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2015.3744DOI Listing
August 2015

Variation analysis of affinity-membrane model based on Freundlich adsorption.

J Chromatogr A 2006 May 3;1114(1):40-4. Epub 2006 Mar 3.

Biomedical Engineering Research Center, Medical College, Xiamen University, Xiamen 361005, China.

The variation analysis of membrane properties including membrane thickness and pore-size was carried out theoretically by using affinity-membrane model based upon the Freundlich adsorption equation. As the percentage variation of membrane thickness and distribution of pore-size increase, we find that (1) the time of total saturation is delayed; (2) the loading capacity at the point of breakthrough are decreased; (3) solute recovery efficiency and ligand utilization efficiency is decreased; (4) the thickness of unused membrane is increased. The results show that even small variations of thickness and distribution of pore size may severely degrade the membrane performance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2006.02.026DOI Listing
May 2006
-->