Xu-Chao Zhang

Xu-Chao Zhang

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Xu-Chao Zhang

Xu-Chao Zhang

Publications by authors named "Xu-Chao Zhang"

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

Authors:
Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H Dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Ying Chen Kaiyun Yang Gening Jiang Ke Fei Guoping Wu Hsien-Chin Lin Hui-Ling Chen Yao-Huei Fang Fang-Yu Tsai Wan-Shan Hsieh Jinming Yu Victoria L Stevens Ite A Laird-Offringa Crystal N Marconett Linda Rieswijk Ann Chao Pan-Chyr Yang Xiao-Ou Shu Tangchun Wu Y L Wu Dongxin Lin Kexin Chen Baosen Zhou Yun-Chao Huang Takashi Kohno Hongbing Shen Stephen J Chanock Nathaniel Rothman Qing Lan

Genomics 2019 Jul 12. Epub 2019 Jul 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ygeno.2019.07.008DOI Listing
July 2019

Familial association of lung cancer with liver cancer in first-degree relatives.

Cancer Manag Res 2019 28;11:5813-5819. Epub 2019 Jun 28.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.

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http://dx.doi.org/10.2147/CMAR.S199462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605761PMC
June 2019

Clinical Utility of Cerebrospinal Fluid Cell-Free DNA as Liquid Biopsy for Leptomeningeal Metastases in ALK-Rearranged NSCLC.

J Thorac Oncol 2019 May 17;14(5):924-932. Epub 2019 Jan 17.

Guangdong General Hospital, School of Medicine, South China University of Technology, Guangzhou, People's Republic of China; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.01.007DOI Listing
May 2019

A molecular graded prognostic assessment (molGPA) model specific for estimating survival in lung cancer patients with leptomeningeal metastases.

Lung Cancer 2019 May 18;131:134-138. Epub 2019 Mar 18.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Medical Research Center, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2019.03.015DOI Listing
May 2019

Strong Programmed Death Ligand 1 Expression Predicts Poor Response and De Novo Resistance to EGFR Tyrosine Kinase Inhibitors Among NSCLC Patients With EGFR Mutation.

J Thorac Oncol 2018 11 26;13(11):1668-1675. Epub 2018 Jul 26.

Southern Medical University, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.07.016DOI Listing
November 2018

Clinical relevance of PD-L1 expression and CD8+ T cells infiltration in patients with EGFR-mutated and ALK-rearranged lung cancer.

Lung Cancer 2018 11 14;125:86-92. Epub 2018 Sep 14.

School of Medicine, South China University of Technology, Guangzhou, 510006, China; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183056
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http://dx.doi.org/10.1016/j.lungcan.2018.09.010DOI Listing
November 2018

Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression.

BMC Cancer 2018 Nov 26;18(1):1171. Epub 2018 Nov 26.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital and Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.

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http://dx.doi.org/10.1186/s12885-018-5078-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258481PMC
November 2018

EGFR L792H and G796R: Two Novel Mutations Mediating Resistance to the Third-Generation EGFR Tyrosine Kinase Inhibitor Osimertinib.

J Thorac Oncol 2018 09 30;13(9):1415-1421. Epub 2018 May 30.

Southern Medical University, Guangzhou, People's Republic of China; Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183063
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http://dx.doi.org/10.1016/j.jtho.2018.05.024DOI Listing
September 2018

Stromal PD-L1-Positive Regulatory T cells and PD-1-Positive CD8-Positive T cells Define the Response of Different Subsets of Non-Small Cell Lung Cancer to PD-1/PD-L1 Blockade Immunotherapy.

J Thorac Oncol 2018 04 18;13(4):521-532. Epub 2017 Dec 18.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.11.132DOI Listing
April 2018

Characterization of PD-L1 expression in Chinese non-small cell lung cancer patients with PTEN expression as a means for tissue quality screening.

Cancer Immunol Immunother 2018 Mar 6;67(3):471-481. Epub 2017 Dec 6.

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhong-shan Er Road, Guangzhou, 510030, China.

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http://dx.doi.org/10.1007/s00262-017-2098-4DOI Listing
March 2018

Clinical characteristics and sequence complexity of anaplastic lymphoma kinase gene fusions in Chinese lung cancer patients.

Lung Cancer 2017 12 9;114:90-95. Epub 2017 Nov 9.

Medical Research Center, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.11.001DOI Listing
December 2017

A comprehensive review of uncommon EGFR mutations in patients with non-small cell lung cancer.

Lung Cancer 2017 12 7;114:96-102. Epub 2017 Nov 7.

Southern Medical University, Guangzhou, 510080, People's Republic of China; Guangdong Lung Cancer Institute, Guangdong General Hospital (GGH) & Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.11.005DOI Listing
December 2017

Lung Adenocarcinoma Harboring EGFR T790M and In Trans C797S Responds to Combination Therapy of First- and Third-Generation EGFR TKIs and Shifts Allelic Configuration at Resistance.

J Thorac Oncol 2017 11 27;12(11):1723-1727. Epub 2017 Jun 27.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.06.017DOI Listing
November 2017

A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R.

J Thorac Oncol 2017 09 30;12(9):1368-1375. Epub 2017 May 30.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2017.05.018DOI Listing
September 2017

Detection of Driver and Resistance Mutations in Leptomeningeal Metastases of NSCLC by Next-Generation Sequencing of Cerebrospinal Fluid Circulating Tumor Cells.

Clin Cancer Res 2017 Sep 12;23(18):5480-5488. Epub 2017 Jun 12.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0047DOI Listing
September 2017

EGFR T790M ctDNA testing platforms and their role as companion diagnostics: Correlation with clinical outcomes to EGFR-TKIs.

Cancer Lett 2017 09 19;403:186-194. Epub 2017 Jun 19.

Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.06.008DOI Listing
September 2017

Potential Predictive Value of and Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma.

Clin Cancer Res 2017 Jun 30;23(12):3012-3024. Epub 2016 Dec 30.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2554DOI Listing
June 2017

Establishment of a Novel Method for Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance Mutations in Lung Cancer.

Chin Med J (Engl) 2017 Jun;130(12):1446-1453

Medical Research Center, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080; Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

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http://dx.doi.org/10.4103/0366-6999.207478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463475PMC
June 2017

Soluble c-Met Levels Correlated With Tissue c-Met Protein Expression in Patients With Advanced Non-Small-Cell Lung Cancer.

Clin Lung Cancer 2017 01 23;18(1):85-91. Epub 2016 Jun 23.

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.06.008DOI Listing
January 2017

Heterogeneity of the resistance to gefitinib treatment in a non-small cell lung cancer patient with active epidermal growth factor receptor mutation.

Thorac Cancer 2017 Jan 1;8(1):51-53. Epub 2016 Nov 1.

Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1111/1759-7714.12382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217905PMC
January 2017

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.

Authors:
Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Jinming Yu Victoria L Stevens Ite A Laird-Offringa Crystal N Marconett Dongxin Lin Kexin Chen Yi-Long Wu Maria Teresa Landi Hongbing Shen Nathaniel Rothman Takashi Kohno Stephen J Chanock Qing Lan

Hum Mol Genet 2017 01;26(2):454-465

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/hmg/ddw414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856088PMC
January 2017

The Unique Characteristics of MET Exon 14 Mutation in Chinese Patients with NSCLC.

J Thorac Oncol 2016 09 30;11(9):1503-10. Epub 2016 May 30.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.05.016DOI Listing
September 2016

Serial cfDNA assessment of response and resistance to EGFR-TKI for patients with EGFR-L858R mutant lung cancer from a prospective clinical trial.

J Hematol Oncol 2016 09 13;9(1):86. Epub 2016 Sep 13.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, China.

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http://dx.doi.org/10.1186/s13045-016-0316-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020532PMC
September 2016

Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines.

PLoS One 2016 4;11(3):e0149370. Epub 2016 Mar 4.

Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou 510080, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778934PMC
August 2016

Plasma dynamic monitoring of soluble c-Met level for EGFR-TKI treatment in advanced non-small cell lung cancer.

Oncotarget 2016 Jun;7(26):39535-39543

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.9425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129951PMC
June 2016

Anaplastic Lymphoma Kinase Variants and the Percentage of ALK-Positive Tumor Cells and the Efficacy of Crizotinib in Advanced NSCLC.

Clin Lung Cancer 2016 05 21;17(3):223-31. Epub 2015 Sep 21.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2015.09.002DOI Listing
May 2016

Saliva supernatant miR-21: a novel potential biomarker for esophageal cancer detection.

Asian Pac J Cancer Prev 2012 ;13(12):6145-9

Department of Gastroenterology, Guangdong General Hospital, Guangzhou, China.

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http://dx.doi.org/10.7314/apjcp.2012.13.12.6145DOI Listing
April 2016

Synergistic antitumor activity of pro-apoptotic agent PAC-1 with cisplatinum by the activation of CASP3 in pulmonary adenocarcinoma cell line H1299.

Asia Pac J Clin Oncol 2016 Mar 1;12(1):41-51. Epub 2015 Dec 1.

Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/ajco.12419DOI Listing
March 2016

Establishment and application of a multiplex genetic mutation-detection method of lung cancer based on MassARRAY platform.

Cancer Biol Med 2016 Mar;13(1):68-76

Medical Research Center, Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

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http://dx.doi.org/10.28092/j.issn.2095-3941.2015.0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850129PMC
March 2016

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.

Authors:
Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Yun-Chul Hong Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan

Hum Mol Genet 2016 Feb 4;25(3):620-9. Epub 2016 Jan 4.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

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http://hmg.oxfordjournals.org/content/early/2016/01/06/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731021PMC
February 2016

Distribution and prognosis of uncommon metastases from non-small cell lung cancer.

BMC Cancer 2016 Feb 24;16:149. Epub 2016 Feb 24.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1186/s12885-016-2169-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766662PMC
February 2016

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Authors:
Joshua N Sampson William A Wheeler Meredith Yeager Orestis Panagiotou Zhaoming Wang Sonja I Berndt Qing Lan Christian C Abnet Laufey T Amundadottir Jonine D Figueroa Maria Teresa Landi Lisa Mirabello Sharon A Savage Philip R Taylor Immaculata De Vivo Katherine A McGlynn Mark P Purdue Preetha Rajaraman Hans-Olov Adami Anders Ahlbom Demetrius Albanes Maria Fernanda Amary She-Juan An Ulrika Andersson Gerald Andriole Irene L Andrulis Emanuele Angelucci Stephen M Ansell Cecilia Arici Bruce K Armstrong Alan A Arslan Melissa A Austin Dalsu Baris Donald A Barkauskas Bryan A Bassig Nikolaus Becker Yolanda Benavente Simone Benhamou Christine Berg David Van Den Berg Leslie Bernstein Kimberly A Bertrand Brenda M Birmann Amanda Black Heiner Boeing Paolo Boffetta Marie-Christine Boutron-Ruault Paige M Bracci Louise Brinton Angela R Brooks-Wilson H Bas Bueno-de-Mesquita Laurie Burdett Julie Buring Mary Ann Butler Qiuyin Cai Geraldine Cancel-Tassin Federico Canzian Alfredo Carrato Tania Carreon Angela Carta John K C Chan Ellen T Chang Gee-Chen Chang I-Shou Chang Jiang Chang Jenny Chang-Claude Chien-Jen Chen Chih-Yi Chen Chu Chen Chung-Hsing Chen Constance Chen Hongyan Chen Kexin Chen Kuan-Yu Chen Kun-Chieh Chen Ying Chen Ying-Hsiang Chen Yi-Song Chen Yuh-Min Chen Li-Hsin Chien María-Dolores Chirlaque Jin Eun Choi Yi Young Choi Wong-Ho Chow Charles C Chung Jacqueline Clavel Françoise Clavel-Chapelon Pierluigi Cocco Joanne S Colt Eva Comperat Lucia Conde Joseph M Connors David Conti Victoria K Cortessis Michelle Cotterchio Wendy Cozen Simon Crouch Marta Crous-Bou Olivier Cussenot Faith G Davis Ti Ding W Ryan Diver Miren Dorronsoro Laure Dossus Eric J Duell Maria Grazia Ennas Ralph L Erickson Maria Feychting Adrienne M Flanagan Lenka Foretova Joseph F Fraumeni Neal D Freedman Laura E Beane Freeman Charles Fuchs Manuela Gago-Dominguez Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Reina García-Closas Randy D Gascoyne Julie Gastier-Foster Mia M Gaudet J Michael Gaziano Carol Giffen Graham G Giles Edward Giovannucci Bengt Glimelius Michael Goggins Nalan Gokgoz Alisa M Goldstein Richard Gorlick Myron Gross Robert Grubb Jian Gu Peng Guan Marc Gunter Huan Guo Thomas M Habermann Christopher A Haiman Dina Halai Goran Hallmans Manal Hassan Claudia Hattinger Qincheng He Xingzhou He Kathy Helzlsouer Brian Henderson Roger Henriksson Henrik Hjalgrim Judith Hoffman-Bolton Chancellor Hohensee Theodore R Holford Elizabeth A Holly Yun-Chul Hong Robert N Hoover Pamela L Horn-Ross G M Monawar Hosain H Dean Hosgood Chin-Fu Hsiao Nan Hu Wei Hu Zhibin Hu Ming-Shyan Huang Jose-Maria Huerta Jen-Yu Hung Amy Hutchinson Peter D Inskip Rebecca D Jackson Eric J Jacobs Mazda Jenab Hyo-Sung Jeon Bu-Tian Ji Guangfu Jin Li Jin Christoffer Johansen Alison Johnson Yoo Jin Jung Rudolph Kaaks Aruna Kamineni Eleanor Kane Chang Hyun Kang Margaret R Karagas Rachel S Kelly Kay-Tee Khaw Christopher Kim Hee Nam Kim Jin Hee Kim Jun Suk Kim Yeul Hong Kim Young Tae Kim Young-Chul Kim Cari M Kitahara Alison P Klein Robert J Klein Manolis Kogevinas Takashi Kohno Laurence N Kolonel Charles Kooperberg Anne Kricker Vittorio Krogh Hideo Kunitoh Robert C Kurtz Sun-Seog Kweon Andrea LaCroix Charles Lawrence Fernando Lecanda Victor Ho Fun Lee Donghui Li Haixin Li Jihua Li Yao-Jen Li Yuqing Li Linda M Liao Mark Liebow Tracy Lightfoot Wei-Yen Lim Chien-Chung Lin Dongxin Lin Sara Lindstrom Martha S Linet Brian K Link Chenwei Liu Jianjun Liu Li Liu Börje Ljungberg Josep Lloreta Simonetta Di Lollo Daru Lu Eiluv Lund Nuria Malats Satu Mannisto Loic Le Marchand Neyssa Marina Giovanna Masala Giuseppe Mastrangelo Keitaro Matsuo Marc Maynadie James McKay Roberta McKean-Cowdin Mads Melbye Beatrice S Melin Dominique S Michaud Tetsuya Mitsudomi Alain Monnereau Rebecca Montalvan Lee E Moore Lotte Maxild Mortensen Alexandra Nieters Kari E North Anne J Novak Ann L Oberg Kenneth Offit In-Jae Oh Sara H Olson Domenico Palli William Pao In Kyu Park Jae Yong Park Kyong Hwa Park Ana Patiño-Garcia Sofia Pavanello Petra H M Peeters Reury-Perng Perng Ulrike Peters Gloria M Petersen Piero Picci Malcolm C Pike Stefano Porru Jennifer Prescott Ludmila Prokunina-Olsson Biyun Qian You-Lin Qiao Marco Rais Elio Riboli Jacques Riby Harvey A Risch Cosmeri Rizzato Rebecca Rodabough Eve Roman Morgan Roupret Avima M Ruder Silvia de Sanjose Ghislaine Scelo Alan Schned Fredrick Schumacher Kendra Schwartz Molly Schwenn Katia Scotlandi Adeline Seow Consol Serra Massimo Serra Howard D Sesso Veronica Wendy Setiawan Gianluca Severi Richard K Severson Tait D Shanafelt Hongbing Shen Wei Shen Min-Ho Shin Kouya Shiraishi Xiao-Ou Shu Afshan Siddiq Luis Sierrasesúmaga Alan Dart Loon Sihoe Christine F Skibola Alex Smith Martyn T Smith Melissa C Southey John J Spinelli Anthony Staines Meir Stampfer Marianna C Stern Victoria L Stevens Rachael S Stolzenberg-Solomon Jian Su Wu-Chou Su Malin Sund Jae Sook Sung Sook Whan Sung Wen Tan Wei Tang Adonina Tardón David Thomas Carrie A Thompson Lesley F Tinker Roberto Tirabosco Anne Tjønneland Ruth C Travis Dimitrios Trichopoulos Fang-Yu Tsai Ying-Huang Tsai Margaret Tucker Jenny Turner Claire M Vajdic Roel C H Vermeulen Danylo J Villano Paolo Vineis Jarmo Virtamo Kala Visvanathan Jean Wactawski-Wende Chaoyu Wang Chih-Liang Wang Jiu-Cun Wang Junwen Wang Fusheng Wei Elisabete Weiderpass George J Weiner Stephanie Weinstein Nicolas Wentzensen Emily White Thomas E Witzig Brian M Wolpin Maria Pik Wong Chen Wu Guoping Wu Junjie Wu Tangchun Wu Wei Wu Xifeng Wu Yi-Long Wu Jay S Wunder Yong-Bing Xiang Jun Xu Ping Xu Pan-Chyr Yang Tsung-Ying Yang Yuanqing Ye Zhihua Yin Jun Yokota Ho-Il Yoon Chong-Jen Yu Herbert Yu Kai Yu Jian-Min Yuan Andrew Zelenetz Anne Zeleniuch-Jacquotte Xu-Chao Zhang Yawei Zhang Xueying Zhao Zhenhong Zhao Hong Zheng Tongzhang Zheng Wei Zheng Baosen Zhou Meng Zhu Mariagrazia Zucca Simina M Boca James R Cerhan Giovanni M Ferri Patricia Hartge Chao Agnes Hsiung Corrado Magnani Lucia Miligi Lindsay M Morton Karin E Smedby Lauren R Teras Joseph Vijai Sophia S Wang Paul Brennan Neil E Caporaso David J Hunter Peter Kraft Nathaniel Rothman Debra T Silverman Susan L Slager Stephen J Chanock Nilanjan Chatterjee

J Natl Cancer Inst 2015 Dec 12;107(12):djv279. Epub 2015 Oct 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JNS, OP, SIB, QL, CCA, LTA, JDF, MTL, LM, SAS, PRT, KAM, PR, DA, DB, BAB, AB, LBr, WHC, CCC, JSC, JFFJr, NDF, LEBF, MGC, AMG, RNH, NH, WH, PDI, BTJ, CK, CMK, LML, MSL, LEM, LPO, RSSS, WeiT, MT, CWa, SW, NW, KY, PH, LMM, NEC, NR, DTS, SJC, NC); Information Management Services, Silver Spring, MD (WAW, CG); Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD (MY, ZW, LBu, AH, CLi); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (IDV, KAB, BMB, CoC, MCB, CF, EG, SL, JP, MSt, DJH); Department of Epidemiology, Harvard School of Public Health, Boston, MA (IDV, OA, KAB, CoC, MCB, EG, RSK, SL, JP, HDS, MSt, DTr, DJH, PK); Ontario Health Study, Toronto, Ontario, Canada (MPP); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (HOA, EWe); Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (AA, MF); UCL Cancer Institute, London, UK (MFA, AMF, DH); Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK (MFA, AMF, DH, RT); Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (SJA, JS, YLW, XCZ); Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden (UA, RH, BSM); Division of Urologic Surgery, Washington University School of Medicine, Saint Louis, MO (GAJr, RGIII); Litwin Centre for Cancer Genetics, University of Toronto, Ontario, Canada (ILA, NG, JSW); Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (ILA, SG, NG, JSW); Hematology Unit, Ospedale Oncologico di Riferimento Regionale A. Businco, Cagliari, Italy (EA); Department of Medicin

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December 2015

Predictive and prognostic value of de novo MET expression in patients with advanced non-small-cell lung cancer.

Lung Cancer 2015 Dec 8;90(3):375-80. Epub 2015 Nov 8.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.10.021DOI Listing
December 2015

Rare discrepancies in a driver gene alteration within histologically heterogeneous primary lung cancers.

Lung Cancer 2015 Nov 11;90(2):205-11. Epub 2015 Sep 11.

Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.09.007DOI Listing
November 2015

Integrative Analyses of Lung Squamous Cell Carcinoma in Ten Chinese Patients with Transcriptome Sequencing.

J Genet Genomics 2015 Oct 30;42(10):579-587. Epub 2015 Sep 30.

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China; The First Clinic College of South China University of Technology, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2015.09.007DOI Listing
October 2015

The BCL11A-XL expression predicts relapse in squamous cell carcinoma and large cell carcinoma.

J Thorac Dis 2015 Sep;7(9):1630-6

1 Southern Medical University, Graduate School, Guangzhou, China ; 2 Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.09.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598500PMC
September 2015

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia.

Authors:
Mitchell J Machiela Chao Agnes Hsiung Xiao-Ou Shu Wei Jie Seow Zhaoming Wang Keitaro Matsuo Yun-Chul Hong Adeline Seow Chen Wu H Dean Hosgood Kexin Chen Jiu-Cun Wang Wanqing Wen Richard Cawthon Nilanjan Chatterjee Wei Hu Neil E Caporaso Jae Yong Park Chien-Jen Chen Yeul Hong Kim Young Tae Kim Maria Teresa Landi Hongbing Shen Charles Lawrence Laurie Burdett Meredith Yeager I-Shou Chang Tetsuya Mitsudomi Hee Nam Kim Gee-Chen Chang Bryan A Bassig Margaret Tucker Fusheng Wei Zhihua Yin She-Juan An Biyun Qian Victor Ho Fun Lee Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Jin Hee Kim Yu-Tang Gao Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Amy Hutchinson Wen-Chang Wang Robert J Klein Charles C Chung In-Jae Oh Kuan-Yu Chen Sonja I Berndt Wei Wu Jiang Chang Xu-Chao Zhang Ming-Shyan Huang Hong Zheng Junwen Wang Xueying Zhao Yuqing Li Jin Eun Choi Wu-Chou Su Kyong Hwa Park Sook Whan Sung Yuh-Min Chen Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen William Pao Young-Chul Kim Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Jian Su Chih-Liang Wang Haixin Li Alan Dart Loon Sihoe Zhenhong Zhao Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Takashi Kohno Sun-Seog Kweon Chih-Yi Chen Roel C H Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Wong-Ho Chow Bu-Tian Ji John K C Chan Minjie Chu Yao-Jen Li Jun Yokota Jihua Li Hongyan Chen Yong-Bing Xiang Chong-Jen Yu Hideo Kunitoh Guoping Wu Li Jin Yen-Li Lo Kouya Shiraishi Ying-Hsiang Chen Hsien-Chih Lin Tangchun Wu Maria Pik Wong Yi-Long Wu Pan-Chyr Yang Baosen Zhou Min-Ho Shin Joseph F Fraumeni Wei Zheng Dongxin Lin Stephen J Chanock Nathaniel Rothman Qing Lan

Int J Cancer 2015 Jul 29;137(2):311-9. Epub 2014 Dec 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733320PMC
July 2015

Accidental invisible intrathoracic disseminated pT4-M1a: a distinct lung cancer with favorable prognosis.

J Thorac Dis 2015 Jul;7(7):1205-12

1 Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China ; 2 Southern Medical University, Guangzhou 510080, China.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.05.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522477PMC
July 2015

Single nucleotide polymorphisms of MAGE-A3 gene and its clinical implications in Chinese patients with non-small cell lung cancer (NSCLC).

Chin J Cancer Res 2015 Jun;27(3):301-8

Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

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http://dx.doi.org/10.3978/j.issn.1000-9604.2014.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490200PMC
June 2015

Lung adenocarcinoma harboring concomitant EGFR mutation and EML4-ALK fusion that benefits from three kinds of tyrosine kinase inhibitors: a case report and literature review.

Clin Lung Cancer 2015 Mar 18;16(2):e5-9. Epub 2014 Nov 18.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Science, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2014.11.001DOI Listing
March 2015

Responses to crizotinib in a patient with c-ros oncogene 1, receptor tyrosine kinase-positive advanced lung adenocarcinoma: A case report.

Oncol Lett 2014 Dec 26;8(6):2624-2626. Epub 2014 Sep 26.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.

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http://dx.doi.org/10.3892/ol.2014.2571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214434PMC
December 2014

Prognostic significance of genotype and number of metastatic sites in advanced non-small-cell lung cancer.

Clin Lung Cancer 2014 Nov 23;15(6):441-7. Epub 2014 Jun 23.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2014.06.006DOI Listing
November 2014

Reduced chemotherapy sensitivity in EGFR-mutant lung cancer patient with frontline EGFR tyrosine kinase inhibitor.

Lung Cancer 2014 Nov 18;86(2):219-24. Epub 2014 Sep 18.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.09.008DOI Listing
November 2014

Lung cancer treatment disparities in China: a question in need of an answer.

Oncologist 2014 Oct 15;19(10):1084-90. Epub 2014 Sep 15.

Southern Medical University, Guangzhou, Guangdong, People's Republic of China; Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China

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http://dx.doi.org/10.1634/theoncologist.2014-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201006PMC
October 2014

Efficacy of epidermal growth factor receptor inhibitors versus chemotherapy as second-line treatment in advanced non-small-cell lung cancer with wild-type EGFR: a meta-analysis of randomized controlled clinical trials.

Lung Cancer 2014 Jul 13;85(1):66-73. Epub 2014 Apr 13.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Science, Guangzhou, PR China. Electronic address:

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July 2014

Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay.

Chin J Cancer 2014 Jul 8;33(7):346-50. Epub 2014 May 8.

Medical Research Center of Guangdong General Hospital; Guangdong Lung Cancer Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P. R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110467PMC
July 2014

A multicenter phase II study of sorafenib monotherapy in clinically selected patients with advanced lung adenocarcinoma after failure of EGFR-TKI therapy (Chinese Thoracic Oncology Group, CTONG 0805).

Lung Cancer 2014 Mar 5;83(3):369-73. Epub 2014 Jan 5.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address:

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March 2014

Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation.

Clin Cancer Res 2014 Mar 17;20(5):1383-92. Epub 2014 Jan 17.

Authors' Affiliations: Division of Pulmonary Oncology, Cancer Center, Guangdong Lung Cancer Institute; Medical Research Center, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou; and State Key Laboratory of Southern China, The Chinese University of Hong Kong, Sir YK Pau Cancer Center, Prince of Wales Hospital, Hong Kong, China.

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March 2014

Feasibility of computed tomography-guided core needle biopsy in producing state-of-the-art clinical management in Chinese lung cancer.

Thorac Cancer 2014 Mar 3;5(2):155-61. Epub 2014 Mar 3.

Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences Guangzhou, China.

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http://dx.doi.org/10.1111/1759-7714.12076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704315PMC
March 2014

Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells.

PLoS One 2013 16;8(7):e69104. Epub 2013 Jul 16.

Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069104PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712950PMC
February 2014

High expression of truncated GLI3 is associated with poor overall survival in patients with non-small cell lung cancer.

Cancer Biomark 2013 ;13(1):37-47

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

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http://dx.doi.org/10.3233/CBM-130312DOI Listing
January 2014

Disease flare after EGFR tyrosine kinase inhibitor cessation predicts poor survival in patients with non-small cell lung cancer.

Pathol Oncol Res 2013 Oct 29;19(4):833-8. Epub 2013 May 29.

Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1007/s12253-013-9651-zDOI Listing
October 2013

Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in males, smokers, and non-adenocarcinoma lung cancer in patients with EGFR mutations.

Int J Biol Markers 2013 Sep 27;28(3):249-58. Epub 2013 Sep 27.

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou - China.

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http://dx.doi.org/10.5301/jbm.5000039DOI Listing
September 2013

KRAS mutation in patients with lung cancer: a predictor for poor prognosis but not for EGFR-TKIs or chemotherapy.

Ann Surg Oncol 2013 Apr 4;20(4):1381-8. Epub 2012 Dec 4.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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April 2013

Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer.

Lung Cancer 2013 Jan 15;79(1):33-9. Epub 2012 Oct 15.

Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, PR China.

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January 2013

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Authors:
Qing Lan Chao A Hsiung Keitaro Matsuo Yun-Chul Hong Adeline Seow Zhaoming Wang H Dean Hosgood Kexin Chen Jiu-Cun Wang Nilanjan Chatterjee Wei Hu Maria Pik Wong Wei Zheng Neil Caporaso Jae Yong Park Chien-Jen Chen Yeul Hong Kim Young Tae Kim Maria Teresa Landi Hongbing Shen Charles Lawrence Laurie Burdett Meredith Yeager Jeffrey Yuenger Kevin B Jacobs I-Shou Chang Tetsuya Mitsudomi Hee Nam Kim Gee-Chen Chang Bryan A Bassig Margaret Tucker Fusheng Wei Zhihua Yin Chen Wu She-Juan An Biyun Qian Victor Ho Fun Lee Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Jin Hee Kim Yu-Tang Gao Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Amy Hutchinson Wen-Chang Wang Robert Klein Charles C Chung In-Jae Oh Kuan-Yu Chen Sonja I Berndt Xingzhou He Wei Wu Jiang Chang Xu-Chao Zhang Ming-Shyan Huang Hong Zheng Junwen Wang Xueying Zhao Yuqing Li Jin Eun Choi Wu-Chou Su Kyong Hwa Park Sook Whan Sung Xiao-Ou Shu Yuh-Min Chen Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen William Pao Young-Chul Kim Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Jian Su Chih-Liang Wang Haixin Li Alan Dart Loon Sihoe Zhenhong Zhao Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Takashi Kohno Sun-Seog Kweon Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Wong-Ho Chow Bu-Tian Ji John K C Chan Minjie Chu Yao-Jen Li Jun Yokota Jihua Li Hongyan Chen Yong-Bing Xiang Chong-Jen Yu Hideo Kunitoh Guoping Wu Li Jin Yen-Li Lo Kouya Shiraishi Ying-Hsiang Chen Hsien-Chih Lin Tangchun Wu Yi-Long Wu Pan-Chyr Yang Baosen Zhou Min-Ho Shin Joseph F Fraumeni Dongxin Lin Stephen J Chanock Nathaniel Rothman

Nat Genet 2012 Dec 11;44(12):1330-5. Epub 2012 Nov 11.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/ng.2456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169232PMC
December 2012

Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors.

Cancer Chemother Pharmacol 2012 Nov 2;70(5):707-16. Epub 2012 Sep 2.

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://link.springer.com/content/pdf/10.1007/s00280-012-1946
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http://link.springer.com/10.1007/s00280-012-1946-3
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November 2012

A clinical model to estimate the pretest probability of lung cancer, based on 1198 pedigrees in China.

J Thorac Oncol 2012 Oct;7(10):1534-40

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1097/JTO.0b013e3182641b82DOI Listing
October 2012

Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer.

Exp Ther Med 2012 Aug 16;4(2):226-230. Epub 2012 May 16.

Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P.R. China.

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http://dx.doi.org/10.3892/etm.2012.577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460290PMC
August 2012

Posttreatment plasma VEGF levels may be associated with the overall survival of patients with advanced non-small cell lung cancer treated with bevacizumab plus chemotherapy.

Med Oncol 2012 Jun 3;29(2):627-32. Epub 2011 Apr 3.

Medical Research Center of Guangdong General Hospital, Guangdong Lung Cancer Institute, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, Peoples Republic of China.

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http://dx.doi.org/10.1007/s12032-011-9924-xDOI Listing
June 2012

CYP1A1*2A polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI and its combined effects with EGFR intron 1 (CA)n polymorphism.

Eur J Cancer 2011 Sep 26;47(13):1962-70. Epub 2011 May 26.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejca.2011.04.018DOI Listing
September 2011

Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer.

J Clin Oncol 2011 Aug 25;29(24):3316-21. Epub 2011 Jul 25.

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://ascopubs.org/doi/10.1200/JCO.2010.33.3757
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August 2011

Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer.

Chin Med J (Engl) 2011 Aug;124(16):2457-60

Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China.

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August 2011

In vitro sequence-dependent synergism between paclitaxel and gefitinib in human lung cancer cell lines.

Cancer Chemother Pharmacol 2011 Mar 22;67(3):637-46. Epub 2010 May 22.

Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People's Republic of China.

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http://dx.doi.org/10.1007/s00280-010-1347-4DOI Listing
March 2011

Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib.

J Hematol Oncol 2011 Jan 21;4. Epub 2011 Jan 21.

Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital & Guangdong Academy of Medical Sciences, No,106, Zhongshan 2nd Rd, Guangzhou, Postal code:510080, People's Republic of China.

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http://dx.doi.org/10.1186/1756-8722-4-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035578PMC
January 2011

Genetic evolution of epidermal growth factor receptor in adenocarcinoma with a bronchioloalveolar carcinoma component.

Clin Lung Cancer 2010 May;11(3):160-8

Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.3816/CLC.2010.n.020DOI Listing
May 2010

RRM1 single nucleotide polymorphism -37C-->A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy.

J Hematol Oncol 2010 Mar 13;3:10. Epub 2010 Mar 13.

Guangdong Lung Cancer Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

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http://dx.doi.org/10.1186/1756-8722-3-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855513PMC
March 2010

Mutation of plakophilin-2 gene in arrhythmogenic right ventricular cardiomyopathy.

Chin Med J (Engl) 2009 Feb;122(4):403-7

Department of Cardiology Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, China.

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February 2009

[Effect of intra-bone marrow infusion of allogeneic mesenchymal stem cells on reconstruction of marrow mesenchymal stem cells in rat HSCT models].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Dec;16(6):1334-8

Department of Pediatrics, The Third Hospital, SUN Yat-sen University, Guangzhou 510630, Guangdong Province, China.

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December 2008

[BMP-4 and VEGF promote development of hematopoietic stem cells during the embryoid body formation from embryonic stem cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Aug;16(4):855-8

Department of Pediatrics, The Third Hospital, SUN Yat-sen University, Guangzhou 510630, Guangdong Province, China.

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August 2008

[Plasmid-mediated miRNA-1-2 specifically inhibits Hand2 protein expression in H9C2 cells].

Nan Fang Yi Ke Da Xue Xue Bao 2008 Aug;28(9):1559-61, 1567

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.

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August 2008

[Isolation and culture of human embryonic AGM derived HSPCs in hematopoietic culture systems created by AGM stromal cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Jun;16(3):579-83

Department of Pediatrics, The First Hospital, Shantou University Medical College, Shantou 515041, Guangdong Province, China.

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June 2008

[The cytotoxicity of CIK/NK cells stimulated by K562-DC fusion vaccines in NOD/SCID mice model for human erythroleukemia].

Zhonghua Xue Ye Xue Za Zhi 2008 Jan;29(1):39-43

Pediatric Department, Second Affiliated Hospital, SUN Yat-sen University, Guangzhou 510120, China.

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January 2008

[MicroRNAs can be expressed in cardiomyocyte-like cells differentiated from human mesenchymal stem cells].

Nan Fang Yi Ke Da Xue Xue Bao 2007 Dec;27(12):1813-6

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China.

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December 2007

[Comparison of efficacies of allogeneic hematopoietic stem cell transplantations between different routes of administration in mice].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007 Oct;15(5):998-1004

Department of Pediatrics, The Second Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510120, China.

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October 2007

KDR expression is associated with the stage and cigarette smoking of the patients with lung cancer.

J Cancer Res Clin Oncol 2007 Sep 4;133(9):635-42. Epub 2007 May 4.

Lung Cancer Research Institute and Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, 510080, People's Republic of China.

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http://dx.doi.org/10.1007/s00432-007-0214-0DOI Listing
September 2007

[Expression of BMP-4 in stromal cells in vitro derived from human aorta-gonad-mesonephros region].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007 Aug;15(4):772-5

Center for Stem Cell Research, The Second Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510120, China.

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August 2007

[Experiment study of efficacy on hematopoietic reconstitution and GVHD prophylaxis after mesenchymal cell infused by intra-bone marrow cavity or intravenous in rat BMT models].

Zhonghua Xue Ye Xue Za Zhi 2007 Feb;28(2):87-92

Department of Pediatrics, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

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February 2007

[Hematopoietic growth factors expressed in human aorta-gonad-mesonephros (AGM)-derived stromal cells in vitro].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 Oct;14(5):999-1003

Center for Stem Cell Research, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

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October 2006

[Screening and cloning the genes differentially expressed in human embryonic AGM-derived stromal cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 Aug;14(4):726-30

Center for Stem Cell Research, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China.

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August 2006

[Supportive effects of stromal cells from human embryonic aorta-gonad-mesonephros region on umbilical cord blood CD34+ cells].

Zhonghua Xue Ye Xue Za Zhi 2006 Jun;27(6):390-3

Stem Cell Research Center, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China.

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June 2006

[Mesenchymal stem cells from human cord blood promote engraftment of human umbilical cord blood-derived CD34+ cells in NOD/SCID mice].

Zhonghua Xue Ye Xue Za Zhi 2005 Dec;26(12):732-5

Department of Pediatrics, Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510120, China.

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December 2005