Publications by authors named "Xu Lin"

2,464 Publications

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Effects of aerobic exercise and resistance exercise on physical indexes and cardiovascular risk factors in obese and overweight school-age children: A systematic review and meta-analysis.

PLoS One 2021 20;16(9):e0257150. Epub 2021 Sep 20.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Background: Obesity is a serious social and public health problem in the world, especially in children and adolescents. For school-age children with obesity, this stage is in the transition from childhood to adolescence, and both physical, psychological, and external environments will be full of challenges. Studies have showed that school-age children are the largest proportion of people who continue to be obese in adulthood. Physical exercise is considered as an effective way to control weight. Therefore, we focus on this point to study which factors will be improved to reduce childhood obesity.

Objective: To assess the effects of aerobic and resistance exercise on physical indexes, such as body mass index (BMI) and body fat percentage, and cardiovascular risk factors such as VO2peak, triglycerides (TG) and low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), insulin and insulin resistance in school-age children who are overweight or obese.

Method: PubMed, SPORTDiscus, Medline, Cochrane-Library, Scopus, Ovid and Web of Science were searched to locate studies published between 2000 and 2021 in obese and overweight school-age children between 6-12 years old. The articles are all randomized controlled trials (RCTs) and in English. Data were synthesized using a random-effect or a fixed-effect model to analyze the effects of aerobic and resistance exercise on six elements in in school-age children with overweight or obese. The primary outcome measures were set for BMI.

Results: A total of 13 RCTs (504 participants) were identified. Analysis of the between-group showed that aerobic and resistance exercise were effective in improving BMI (MD = -0.66; p < 0.00001), body fat percentage (MD = -1.29; p = 0.02), TG (std.MD = -1.14; p = 0.005), LDL (std.MD = -1.38; p = 0.003), TC (std.MD = -0.77; p = 0.002), VO2peak (std.MD = 1.25; p = 0.001). However, aerobic and resistance exercise were not significant in improving HDL (std.MD = 0.13; p = 0.27).

Conclusions: Aerobic exercise and resistance exercise are associated with improvement in BMI, body fat percentage, VO2peak, TG, LDL, TC, while not in HDL in school-age children with obesity or overweight. Insulin and insulin resistance were not able to be analyzed in our review. However, there are only two articles related to resistance exercise in children with obesity and overweight at school age, which is far less than the number of 12 articles about aerobic exercise, so we cannot compare the effects of the two types of exercises.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0257150PLOS
September 2021

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.

Mod Pathol 2021 Sep 20. Epub 2021 Sep 20.

Kidney Cancer Program at Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting with a median age of 75 years (range 63-86 years) and male to female ratio 2:5. All 22 tumors demonstrated prototypical microscopic features. Tumors were well-circumscribed and solid. They were composed of sheets of tumor cells in compact nests. Tumor cells had eosinophilic cytoplasm, round to oval nuclei (without nuclear membrane irregularities), focal subtle perinuclear halos, and occasional binucleation. Sharply delineated edematous stromal islands were often observed. Tumor cells were positive for PAX8, negative for CD117, and exhibited diffuse and strong cytokeratin-7 expression. Six patients presented with pT1 tumors. At a median follow-up of 29 months, four patients were alive without recurrence (three patients had died from unrelated causes). All tumors were originally classified as chromophobe renal cell carcinoma, eosinophilic variant (chRCC-eo). While none of the patients presented with known syndromic features, one patient with multiple bilateral LOTs was subsequently found to have a likely pathogenic germline TSC1 mutation. Somatic, likely activating, mutations in MTOR and RHEB were identified in all other evaluable LOTs. As assessed by phospho-S6 and phospho-4E-BP1, mTOR complex 1 (mTORC1) was activated across all cases but to different extent. MTOR mutant LOT exhibited lower levels of mTORC1 activation, possibly related to mTORC1 dimerization and the preservation of a wild-type MTOR copy (retained chromosome 1). Supporting its distinction from related entities, gene expression analyses showed that LOT clustered separately from classic chRCC, chRCC-eo, and RO. In summary, converging mTORC1 pathway mutations, mTORC1 complex activation, and a distinctive gene expression signature along with characteristic phenotypic features support LOT designation as a distinct entity with both syndromic and non-syndromic cases associated with an indolent course.
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http://dx.doi.org/10.1038/s41379-021-00896-6DOI Listing
September 2021

Laparoscopic sphincter preserving total pelvic exenteration for recurrent cervical cancer - a video vignette.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Department of Gastrointestinal Surgery, Sichuan Cancer Hospital& Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, China.

About 15-20% patients with cervical cancer present with local recurrence after chemoradiation[1]. Approximately 10% of primary rectal carcinomas present with tumour invasion into adjacent organs without distant metastases, and local recurrence rates after surgery in patients with rectal cancer range between 5-10%.
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http://dx.doi.org/10.1111/codi.15918DOI Listing
September 2021

ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation.

Nucleic Acids Res 2021 Sep 16. Epub 2021 Sep 16.

State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Controlling proper RNA pool for nuclear export is important for accurate gene expression. ZFC3H1 is a key controller that not only facilitates nuclear exosomal degradation, but also retains its bound polyadenylated RNAs in the nucleus upon exosome inactivation. However, how ZFC3H1 retains RNAs and how its roles in RNA retention and degradation are related remain largely unclear. Here, we found that upon degradation inhibition, ZFC3H1 forms nuclear condensates to prevent RNA trafficking to nuclear speckles (NSs) where many RNAs gain export competence. Systematic mapping of ZFC3H1 revealed that it utilizes distinct domains for condensation and RNA degradation. Interestingly, ZFC3H1 condensation activity is required for preventing RNA trafficking to NSs, but not for RNA degradation. Considering that no apparent ZFC3H1 condensates are formed in normal cells, our study suggests that nuclear RNA degradation and retention are two independent mechanisms with different preference for controlling proper export RNA pool-degradation is preferred in normal cells, and condensation retention is activated upon degradation inhibition.
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http://dx.doi.org/10.1093/nar/gkab774DOI Listing
September 2021

Photocatalysis in Supramolecular Fluorescent Metallacycles and Metallacages.

Chem Asian J 2021 Sep 16. Epub 2021 Sep 16.

East China Normal University, Department of Chemistry, CHINA.

The utilization of photocatalytic techniques for achieving light-to-fuel conversion is a promising way to ease the shortage of energy and degradation of the ecological environment. Fluorescent metallacycles and metallacages have drawn considerable attention and have been used in widespread fields due to easy preparation and their abundant functionality including photocatalysis. This review covers recent advances in photocatalysis in discrete supramolecular fluorescent metallacycles and metallacages. The developments in the utilization of the metallacycles skeletons and the effect of fluorescence-resonance energy transfer for photocatalysis are discussed. Furthermore, the use of the ligands decorated by organic chromophores or redox metal sites in metallacages as photocatalysts and their ability to encapsulate appropriate catalytic cofactors for photocatalysis are summarized. For the sake of brevity, macrocycles and cages with inorganic coordination complexes such as ruthenium complexes and iridium complexes are not included in this minireview.
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http://dx.doi.org/10.1002/asia.202100942DOI Listing
September 2021

Incentivizing household recycling crowds out public support for other waste management policies: A long-term quasi-experimental study.

J Environ Manage 2021 Sep 6;299:113675. Epub 2021 Sep 6.

School of Public Affairs, Zhejiang University, Hangzhou, China; Institute for Public Policy of Zhejiang University, Hangzhou, China. Electronic address:

Waste management is a prototypical issue that requires multiple policy measures to function together. Yet, the compatibility between waste management policies is vastly understudied. In this paper, we used a longitudinal quasi-experimental methodology to identify the effect of an incentivized household recycling program in Anji, China on public support for other waste management policies. The program was evaluated six and fifteen months after it was implemented, respectively. We found that, despite its positive influence on residents' self-reported recycling behavior, the program reduced support for policy measures concerning waste prevention and harmless disposal. Consistent with the theoretical propositions, such crowding-out was driven by the decrease in personal commitment to pro-environmental goals, perceived issue importance of environmental sustainability, and perceived importance of individual contribution to environmental goods. Further evidence suggests that the crowding-out effect attenuated but did not disappear in the long run. These findings contribute to a more comprehensive understanding of the holistic relationships between waste management policies, indicating that incentive-based recycling policies can interact negatively with other waste policies by reducing public support for them.
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http://dx.doi.org/10.1016/j.jenvman.2021.113675DOI Listing
September 2021

Brain-derived neurotrophic factor gene variants and obesity in former smokers.

BMC Genomics 2021 Sep 15;22(1):668. Epub 2021 Sep 15.

Institute of geriatrics, the 2nd Medical Center,Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Objective: From genome-wide association studies, brain-derived neurotrophic factor (BDNF) locus on chromosome 11 was the only SNP associated with both smoking and body mass index (BMI) in European, African and Asian population. This study aims to explore the unique genetic predisposition to obesity in former smokers by examining the effects of BDNF on BMI and waist circumference (WC).

Methods: The study design is case-control study with a cohort validation in supplementary. We included 15,072 ethnic Chinese participants in the Guangzhou Biobank Cohort Study (GBCS) with data of four BDNF SNPs related to both BMI and smoking behavior. We used baseline smoke exposure data in 2003-2007 and follow-up outcomes of general obesity (by BMI) and central obesity (WC) in 2008-2012. Odds ratios (ORs) and 95% confidence intervals (CIs) for general obesity and central obesity associated with these SNPs were derived from logistic regression.

Results: Of 15,072 participants (3169 men and 11,903 women), 1664 (11.0%) had general and 7868 (52.2%) had central obesity. In 1233 former smokers, the rs6265 GG, versus AA, genotype was associated with higher risks of general obesity (OR = 1.79, 95% CI = 1.06-3.01) and central obesity (OR = 2.08, 95% CI = 1.47-2.92) after adjustment. These associations were not significant in never or current smokers. In former heavy (≥20 cigarettes/day) smokers, the rs6265 GG genotype showed a higher odds for general obesity (OR = 2.15, 95% CI = 1.05-4.40), while no association was found in former light (1-9 cigarettes/day) smokers. Similar results were found for the association of rs6265 with central obesity and for the associations of other two BDNF SNPs (rs4923457 and rs11030104) with both general and central obesity.

Conclusions: We firstly identified the genetic predisposition (BDNF SNPs) to general and central obesity in former smokers, particularly in former heavy smokers. The different associations of the SNPs for general/central obesity in different smoke exposure groups may be related to the competitive performance of the sites and epigenetic modification, which needs further study.
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http://dx.doi.org/10.1186/s12864-021-07928-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442367PMC
September 2021

Effect and satisfaction evaluation of risk management in nursing management of hemodialysis.

Minerva Surg 2021 Sep 15. Epub 2021 Sep 15.

Blood Purification Department, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, China -

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http://dx.doi.org/10.23736/S2724-5691.21.09074-2DOI Listing
September 2021

Natural menopausal age and cardiovascular disease risk factors in older Chinese women: Guangzhou Biobank Cohort Study.

Menopause 2021 Sep 13. Epub 2021 Sep 13.

School of Public Health, Sun Yat-sen University, Guangzhou, China Molecular Epidemiology Research Centre, Guangzhou Number Twelfth People's Hospital, Guangzhou, China Institute of Applied Health Research, University of Birmingham, Birmingham, UK School of Public Health, The University of Hong Kong, Hong Kong, China.

Objective: To examine the associations of natural menopausal age with cardiovascular disease risk factors and whether the associations varied by parity in older Chinese women.

Methods: Information of demographic characteristics, lifestyles, and reproductive factors was collected by face-to-face interview. Framingham Risk Score was used as an indicator of cardiovascular disease risk, with a score ≥ 10% considered as high cardiovascular disease risk (vs low, dichotomous). Multivariable logistic and linear regressions were used to examine the associations of menopausal age with cardiovascular disease risk factors.

Results: Of 18,339 women aged 50+ years, the average (standard deviation) age was 61.8 (6.9) years. Compared with women with menopausal age of 45 to 54 years, after adjustment for multiple potential confounders, women with menopausal age <45 years or ≥55 years had higher Framingham Risk Score (0.93%, 95% confidence interval: 0.40-1.46, and 0.69%, 95% confidence interval: 0.18-1.20, respectively). Women with menopausal age <45 or ≥55 years had higher odds of high cardiovascular disease risk (vs low) (odds ratio [95% confidence interval]:1.26 (1.10-1.44) and 1.17 (1.02-1.33), respectively). The associations of menopausal age with the Framingham Risk Score varied by parity (P for interaction ≤0.001). The Framingham Risk Score was higher in those with one to three parity (<45 y: 1.01 [0.43-1.59]; ≥55 y: 1.14 [0.60-1.68]) and lower for parity ≥4 (<45 y: -0.33 [-1.84 to 1.18]; ≥55 y: -2.02 [-3.82 to -0.22]). In nulliparous women, the Framingham Risk Score was highest in menopausal age <45 years (3.97 [1.67-6.26]), but the differences were nonsignificant in menopausal age ≥55 years (0.66 [-1.38 to 2.71]).

Conclusions: Both early and late natural menopausal ages were associated with a higher cardiovascular disease risk, and the associations were stronger in those with lower parity.

Video Summary:http://links.lww.com/MENO/A813.
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http://dx.doi.org/10.1097/GME.0000000000001856DOI Listing
September 2021

MicroRNA-7 overexpression positively regulates the CD8 SP cell development via targeting PIK3R1.

Exp Cell Res 2021 Sep 10;407(2):112824. Epub 2021 Sep 10.

Special Key Laboratory of Gene Detection & Therapy of Guizhou Provincial Education Department, Guizhou, 563000, China; Department of Immunology & Talent Base of Biological Therapy of Guizhou Province, Zunyi Medical University, Guizhou, 563000, China. Electronic address:

microRNA-7 (miR-7), a distinct miRNA family member, has been reported to be involved in the biological functions of immune cells. However, the potential role of miR-7 in the CD8 T cell development remains to be elucidated. In this study, we estimated the potential effects of miR-7 overexpression in the thymic CD8 SP cell development using miR-7 overexpression mice. Our results showed that compared with those in control wild type (WT) mice, the volume, weight and total cell numbers of thymus in miR-7 overexpression (OE) mice increased significantly. The absolute cell number of CD8 SP cells in miR-7 OE mice increased and its ability of activation and proliferation enhanced. Futhermore, we clarified that miR-7 overexpression had an intrinsic promote role in CD8 SP cell development by adoptive cell transfer assay. Mechanistically, the expression level of PIK3R1, a target of miR-7, decreased significantly in CD8 SP cells of miR-7 OE mice. Moreover, the expression level of phosphorylated (p)-AKT and p-ERK changed inversely and indicating that miR-7 overexpression impaired the balance of AKE and ERK pathways. In summary, our work reveals an essential role of miR-7 in promoting CD8 SP cell development through the regulation of PIK3R1 and balance of AKT and ERK pathways.
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http://dx.doi.org/10.1016/j.yexcr.2021.112824DOI Listing
September 2021

Modeling and staged assessments of the controllability of spread for repeated outbreaks of COVID-19.

Nonlinear Dyn 2021 Sep 6:1-14. Epub 2021 Sep 6.

School of Mechanical Engineering, Tiangong University, Tianjin, 300387 China.

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has been causing an outbreak of a new type of pneumonia globally, and repeated outbreaks have already appeared. Among the studies on the spread of the COVID-19, few studies have investigated the repeated outbreaks in stages, and the quantitative condition of a controllable spread has not been revealed. In this paper, a brief compartmental model is developed. The effective reproduction number (ERN) of the model is interpreted by the ratio of net newly infectious individuals to net isolation infections to assess the controllability of the spread of COVID-19. It is found that the value of the ERN at the inflection point of the pandemic is equal to one. The effectiveness of the quarantine, even the treatment, is parametrized in various stages with Gompertz functions to increase modeling accuracy. The impacts of the vaccinations are discussed by adding a vaccinated compartment. The results show that the sufficient vaccinations can make the inflection point appear early and significantly reduce subsequent increases in newly confirmed cases. The analysis of the ERNs of COVID-19 in the United States, Spain, France, and Peru confirms that the condition of a repeated outbreak is to relax or lift the interventions related to isolation and quarantine interventions to a level where the ERN is greater than one.
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http://dx.doi.org/10.1007/s11071-021-06568-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419392PMC
September 2021

Alcohol use among patients with epilepsy in western China. A hospital-based study.

Epilepsy Behav 2021 Sep 8;124:108302. Epub 2021 Sep 8.

Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32# W. Sec 2, 1st Ring Rd, Chengdu, Sichuan 610072, People's Republic of China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 32# W. Sec 2, 1st Ring Rd, Chengdu, Sichuan 610072, People's Republic of China. Electronic address:

AMIS: Alcohol consumption has multiple negative consequences for people with epilepsy, including precipitation of seizure or status epilepticus, worsening of seizure control, increased adverse effects of anti-seizure medications, increased sudden unexpected death in epilepsy, and premature mortality. The aim of this study was to investigate alcohol use and explore the sociodemographic and clinical factors associated with alcohol use among patients with epilepsy in western China.

Methods: A face-to-face questionnaire on alcohol use was conducted at Sichuan Provincial People's Hospital from December 2020 to June 2021. All adult patients who came to our epilepsy center (inpatient and outpatient) were invited to participate in this study. Logistic regression was used to evaluate the possible risk factors associated with alcohol use within the last 12 months.

Results: A total of 425 patients completed this study, 24.2% of patients with epilepsy had used alcohol within the last 12 months, being male and having a history of alcohol use were independently associated factors. Among patients who had used alcohol within the last 12 months, 52.4% complained of worsening of seizure control, heavy alcohol use, and frequent alcohol use were independently associated with worsening of seizure control after alcohol use in patients with epilepsy.

Conclusion: This study revealed that the rate of alcohol use among patients with epilepsy was high. Male patients with a history of alcohol use were more prone to alcohol use after a diagnosis of epilepsy. Heavy alcohol use and frequent alcohol use were independently associated with worsening of seizure control after alcohol use in patients with epilepsy. Patient education on the destructive effects of alcohol use is needed for patients with epilepsy.
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http://dx.doi.org/10.1016/j.yebeh.2021.108302DOI Listing
September 2021

Quercetin-Loaded Ceria Nanocomposite Potentiate Dual-Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation.

Small 2021 Sep 9:e2101505. Epub 2021 Sep 9.

Department of Oral Implantology, School of Dentistry, Jilin University, Changchun, 130021, China.

Macrophage polarization toward M1 phenotype (pro-inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria is verified to inhibit M1 polarization of macrophages by the favorable ability of reactive oxygen species (ROS) scavenging. However, the function of nanoceria on macrophage polarization toward M2 phenotype (anti-inflammation) in reparative phase of periodontal inflammation is quite limited. In this work, by introducing an antioxidant drug quercetin onto nano-octahedral ceria, synergistic and intense regulation of host immunity against periodontal disease is realized. Such nanocomposite can control the phenotypic switch of macrophages by not only inhibition of M1 polarization for suppressing the damage in the destructive phase but also promotion of M2 polarization for regenerating the surrounding tissues in reparative phase of periodontal disease. As-prepared nanocomposite can effectively increase the M2/M1 ratio of macrophage polarization in inflammatory cellular models by lipopolysaccharide stimulation. More importantly, the nanocomposite also exerts an improved therapeutic potential against local inflammation by significant downregulation of pro-inflammatory cytokines and upregulation of anti-inflammatory cytokines in an animal model with periodontal inflammation. Therefore, this newly developed nanomedicine is efficient in ROS scavenging and driving pro-inflammatory macrophages to the anti-inflammatory phenotype to eliminate inflammation, thereby providing a promising candidate for treating periodontal inflammation.
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http://dx.doi.org/10.1002/smll.202101505DOI Listing
September 2021

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.

Nat Commun 2021 09 6;12(1):5270. Epub 2021 Sep 6.

Department of Molecular Biology, the Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Following injury, cells in regenerative tissues have the ability to regrow. The mechanisms whereby regenerating cells adapt to injury-induced stress conditions and activate the regenerative program remain to be defined. Here, using the mammalian neonatal heart regeneration model, we show that Nrf1, a stress-responsive transcription factor encoded by the Nuclear Factor Erythroid 2 Like 1 (Nfe2l1) gene, is activated in regenerating cardiomyocytes. Genetic deletion of Nrf1 prevented regenerating cardiomyocytes from activating a transcriptional program required for heart regeneration. Conversely, Nrf1 overexpression protected the adult mouse heart from ischemia/reperfusion (I/R) injury. Nrf1 also protected human induced pluripotent stem cell-derived cardiomyocytes from doxorubicin-induced cardiotoxicity and other cardiotoxins. The protective function of Nrf1 is mediated by a dual stress response mechanism involving activation of the proteasome and redox balance. Our findings reveal that the adaptive stress response mechanism mediated by Nrf1 is required for neonatal heart regeneration and confers cardioprotection in the adult heart.
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http://dx.doi.org/10.1038/s41467-021-25653-wDOI Listing
September 2021

Prediction model for cardiovascular disease risk in hemodialysis patients.

Int Urol Nephrol 2021 Sep 6. Epub 2021 Sep 6.

Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China.

Purpose: To derive and validate a prediction score for cardiovascular disease (CVD) risk in hemodialysis patients in China.

Methods: Three hundred and eighty-eight patients with regular hemodialysis for more than 3 months were recruited from January 1, 2015 to September 30, 2019 and followed up till May 31, 2020. We derived a prediction score using all participants as a training data set and validated using a bootstrap validation data set. Discriminatory ability of the prediction score was assessed by the area under the receiver operating characteristic curve (AUC).

Results: Of 388 patients without CVD at baseline, 132 developed first CVD events during an average follow-up of 3.27 (inter-quartile range = 3.08) years. Of 26 clinical parameters, age, hypertension, diabetes and abnormal white blood cell (WBC) count were identified as significant predictors and included in the prediction model. Compared to those without any of these risk factors, those with one, two, and three to four points showed increased risks of CVD, with the adjusted hazards ratio and 95% confidence interval (CI) being 3.29 (1.17-9.26), 7.42 (2.68-20.51) and 15.43 (5.44-43.75), respectively. The score showed satisfactory discriminatory ability in both training and validation data set (AUC = 0.7025, 95% CI 0.6520-0.7530, and 0.6876, 95% CI 0.6553-0.7200, respectively).

Conclusion: We derived and validated a prediction score for CVD risk in hemodialysis patients in China. Given there is a rapid increase in the number of hemodialysis patients, this simple point score can be used to identify high-risk individuals in clinical practice for more precise and efficient personalized treatment.
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http://dx.doi.org/10.1007/s11255-021-02984-7DOI Listing
September 2021

Middle-aged and elderly users' continuous usage intention of health maintenance-oriented WeChat official accounts: empirical study based on a hybrid model in China.

BMC Med Inform Decis Mak 2021 Sep 3;21(1):257. Epub 2021 Sep 3.

College of Medical Informatics, Chongqing Medical University, Chongqing, China.

Background: Although middle-aged and elderly users are the main group targeted by health maintenance-oriented WeChat official accounts (HM-WOAs), few studies have explored the relationship of these accounts and their users. Exploring the factors that influence the continuous adoption of WOAs is helpful to strengthen the health education of middle-aged and elderly individuals.

Objective: We developed a new theoretical model and explored the factors that influence middle-aged and elderly individuals' continuous usage intention for HM-WOA. Performance expectancy mediated the effects of the model in explaining continuous usage intention and introduced health literacy into the model.

Methods: We established a hybrid theoretical model on the basis of the unified theory of acceptance and use of technology 2 model (UTAUT2), the health belief model (BHM), protection motivation theory (PMT), and health literacy. We collected valid responses from 396 middle-aged and elderly users aged ≥ 45 years in China. To verify our hypotheses, we analyzed the data using structural equation modeling.

Results: Performance expectancy (β = 0.383, P < 0.001), hedonic motivation (β = 0.502, P < 0.001), social influence (β = 0.134, P = 0.049), and threat appraisal (β = 0.136, P < 0.001) positively influenced middle-aged and elderly users' continuous usage intention. Perceived health threat (β =  - 0.065, P = 0.053) did not have a significant effect on continuous usage intention. Both threat appraisal (β = 0.579, P < 0.001) and health literacy (β = 0.579, P < 0.001) positively affected performance expectancy. Threat appraisal indirectly affected continuous usage intention through performance expectancy mediation.

Conclusions: Our new theoretical model is useful for understanding middle-aged and elderly users' continuous usage intention for HM-WOA. Performance expectancy plays a mediation role between threat appraisal and continuous usage intention, and health literacy positively affects performance expectancy.
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http://dx.doi.org/10.1186/s12911-021-01625-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413706PMC
September 2021

Clinical value of SMI Combined with Low-Dose CT Scanning in differential diagnosis of Thyroid Lesions and Tumor Staging.

Pak J Med Sci 2021 Sep-Oct;37(5):1347-1352

Lin Xu, Department of Radiology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, P. R. China.

Objectives: To investigate the clinical value of Superb Microvascular Imaging (SMI) combined with low dose CT scanning in differential diagnosis of thyroid lesions and tumor staging.

Methods: A total of 120 patients with thyroid nodules admitted to the Chinese PLA General Hospital from January 2017 to July 2020 were selected. Paired design was adopted in this study. SMI and SMI combined with low-dose CT scanning were respectively carried out to these patients. The results were judged by two senior imaging physicians and two senior sonographers respectively. And t-test, χ test, Pearson correlation coefficient check and other methods were adopted to comparatively analyze the above two methods and the pathological results after operation or puncture.

Results: Compared with pathologic findings, the coincidence rate of SMI was 40%, and the coincidence rate of SMI combined with low dose CT scanning was 84%. The difference was significant (p=0.00); among the 120 thyroid nodule patients, 50 were diagnosed as malignant by pathological diagnosis, and 70 as benign; 27 malignant cases and 93 benign cases were detected by SMI; 48 malignant cases and 72 benign cases were detected by SMI combined with low dose CT scanning. The sensitivity and accuracy of the latter were significantly higher than those of the former, and the difference was statistically significant (p=0.00); the enhancement, edge sharpness and homogeneity of SMI increased with the increase of tumor malignancy, showing positive correlation property.

Conclusion: SMI combined with low dose CT scanning has a higher diagnostic coincidence rate. Its sensitivity and accuracy are significantly superior. With the increase of tumor malignancy, the enhancement and unhomogeneity of SMI increase, and the edge is more blurred. That suggests: with the increase of tumor malignancy, neovascularization in the tumor is more obvious and more unevenly distributed; the increase of edge blur indicates more obvious tumor infiltration. The method has considerable clinical value for predicting the malignancy of tumors.
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http://dx.doi.org/10.12669/pjms.37.5.4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377899PMC
January 2021

Human gut microbiome impacts skeletal muscle mass via gut microbial synthesis of the short-chain fatty acid butyrate among healthy menopausal women.

J Cachexia Sarcopenia Muscle 2021 Sep 1. Epub 2021 Sep 1.

Center for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, Hunan, China.

Background: Increasing evidence suggests that human gut microbiome plays an important role in variation of skeletal muscle mass (SMM). However, specific causal mechanistic relationship of human gut microbiome with SMM remains largely unresolved. Understanding the causal mechanistic relationship may provide a basis for novel interventions for loss of SMM. This study investigated whether human gut microbiome has a causal effect on SMM among Chinese community-dwelling healthy menopausal women.

Methods: Estimated SMM was derived from whole-body dual-energy X-ray absorptiometry. We performed integrated analyses on whole-genome sequencing, shotgun metagenomic sequencing, and serum short-chain fatty acids (SCFAs), as well as available host SMM measurements among community-dwelling healthy menopausal women (N = 482). We combined the results with summary statistics from genome-wide association analyses for human gut microbiome (N = 952) and SMM traits (N = 28 330). As a prerequisite for causality, we used a computational protocol that was proposed to measure correlations among gut metagenome, metabolome, and the host trait to investigate the relationship between human gut microbiome and SMM. Causal inference methods were applied to assess the potential causal effects of gut microbial features on SMM, through one-sample and two-sample Mendelian randomization (MR) analyses, respectively.

Results: In metagenomic association analyses, the increased capacity for gut microbial synthesis of the SCFA butyrate was significantly associated with serum butyrate levels [Spearman correlation coefficient (SCC) = 0.13, P = 0.02] and skeletal muscle index (SCC = 0.084, P = 0.002). Of interest was the finding that two main butyrate-producing bacterial species were both positively associated with the increased capacity for gut microbial synthesis of butyrate [Faecalibacterium prausnitzii (SCC = 0.25, P = 6.6 × 10 ) and Butyricimonas virosa (SCC = 0.15, P = 0.001)] and for skeletal muscle index [F. prausnitzii (SCC = 0.16, P = 6.2 × 10 ) and B. virosa (SCC = 0.17, P = 2.4 × 10 )]. One-sample MR results showed a causal effect between gut microbial synthesis of the SCFA butyrate and appendicular lean mass (β = 0.04, 95% confidence interval 0.029 to 0.051, P = 0.003). Two-sample MR results further confirmed the causal effect between gut microbial synthesis of the SCFA butyrate and appendicular lean mass (β = 0.06, 95% confidence interval 0 to 0.13, P = 0.06).

Conclusions: Our results may help the future development of novel intervention approaches for preventing or alleviating loss of SMM.
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http://dx.doi.org/10.1002/jcsm.12788DOI Listing
September 2021

The effect of aging on beef taste, aroma and texture, and the role of microorganisms: a review.

Crit Rev Food Sci Nutr 2021 Aug 31:1-12. Epub 2021 Aug 31.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.

The present review summarizes the advantages and disadvantages of three different aging methods (traditional dry aging, wet aging in vacuum shrink pack and dry aging in a highly moisture-permeable bag), discusses the effects of aging on beef which focus on the formation of taste-active compounds and aroma-active compounds and texture changes, and speculates the role of microbes. All these three aging methods can improve the aroma, flavor and texture of beef to varying degrees. It is concluded that the improvement in the taste during aging may be attributed to the following three aspects: First, the release of reducing sugars from the transition of glycogen and ATP; Second, the formation of free amino acids (FAAs) and peptides through proteolysis; Third, IMP, GMP, inosine and hypoxanthine which are produced by the degradation of nucleotides. The improvement of aroma is related to the volatile aroma-active components, which are produced by the thermal oxidation/degradation of fatty acids and the Maillard reaction between amino acids and reducing sugars during aging. And the change of texture is mainly owing to the degradation of cytoskeletal myofibrin and collagen with intramural connective tissue in meat by the endogenous proteolysis system. The role of microorganism in aging will be the main direction of further research.
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http://dx.doi.org/10.1080/10408398.2021.1971156DOI Listing
August 2021

Left Atrial Strain and Compliance Correlate with Diastolic Dysfunction Grades and Complications during Pre-eclampsia: A Speckle-Tracking Echocardiography Study.

Ultrasound Med Biol 2021 Aug 26. Epub 2021 Aug 26.

Department of Geriatrics, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China; Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China. Electronic address:

This study aimed to investigate left atrium (LA) strain components in the assessment of cardiac function and its clinical correlates in pre-eclampsia (PE). With the use of speckle tracking echocardiography, phasic LA strain and (LASr)/(E/e'), the surrogate of LA compliance, were compared between healthy pregnant women (n = 70) and those with PE (n = 146) and among different diastolic dysfunction (DD) grades in PE. Receiver operating characteristic curves and logistic regression analysis were used to identify the role of strain components in distinguishing DD grades and predicting cardiac complications. LA reservoir strain, conduit strain and LA compliance reduced significantly in PE (p < 0.01). LASr/(E/e') gradually decreased with worsening DD and LASr/(E/e') <3.40 was the independent risk factor for cardiac events in PE (p < 0.01). This study observed significantly decreased LA strain and compliance in PE. Notably, LA compliance decreased progressively with the severity of DD, and LASr/(E/e') <3.40 is the independent risk factor for cardiac complications during PE pregnancy.
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http://dx.doi.org/10.1016/j.ultrasmedbio.2021.08.003DOI Listing
August 2021

Effects of itol A on the larval growth and development of Spodoptera frugiperda (Lepidoptera: Noctuidae).

Pest Manag Sci 2021 Aug 28. Epub 2021 Aug 28.

Guangxi Key Laboratory of Agric-Environment and Agric-Product Safety, National Demonstration Center for Experimental Plant Science Education, College of Agriculture, Guangxi University, Nanning, Guangxi, 530004, People's Republic of China.

Background: Itol A, extracted from the Itoa orientalis Hemsl. (Flacourtiaceae), possesses bioactivity on Spodoptera litura (Lepidoptera: Noctuidae) and Nilaparvata lugens (Stål) (Hemiptera: Delphacidae). Our previous study showed that the effects on Spodoptera frugiperda, a destructive pest found worldwide, were similar to those of fenoxycarb (FC), a juvenile hormone analog (JHA). Thus, we speculate that itol A could have growth-regulating effects. The current work explored juvenile hormone (JH) levels and mRNA levels of crucial JH signaling pathway enzyme genes in S. frugiperda larvae treated with itol A and FC.

Results: Itol A caused severe growth obstacles in S. frugiperda, extended the larval duration and reduced the mean worm weight and body length rates. 3 and 7 d after exposure to a sublethal concentration of itol A (500 mg/L), the JH level of the larvae significantly decreased by 36.59% and 22.70%, respectively. qPCR inferred that the mRNA expression levels of crucial JH metabolism enzymes (SfJHE and SfJHEH) significantly raised by 6.58-fold and 2.12-fold, respectively, relative to the control group 3 d after treatment.

Conclusions: Itol A adversely affects the development of S. frugiperda, We propose that this effect was caused by decreasing JH levels and disrupting the JH signaling pathway via mediating its synthetic and metabolic. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/ps.6614DOI Listing
August 2021

Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank.

Int J Cancer 2021 Aug 27. Epub 2021 Aug 27.

Department of Epidemiology, School of Public Health, Southeast University, Nanjing, China.

Chronic inflammation has been associated with the development of lung cancer. In this study, we examined the association between C-reactive protein (CRP) and lung cancer in a prospective cohort study and used Mendelian randomization (MR) to clarify the causality. We included 420 977 participants from the UK Biobank (UKB) in the analyses; 1892 thereof were diagnosed with lung cancer during the follow-up. Hazards ratios (HRs) of CRP concentrations were estimated by Cox proportional hazard models and two approaches of MR analysis were performed. Besides, we added CRP concentrations to epidemiological model of lung cancer to evaluate its prediagnostic role through time-dependent receiver operating characteristic curve analysis. Elevated CRP levels were associated with a 22% increased lung cancer risk per 1 SD increase (HR = 1.22, 95% confidence interval [CI] = 1.18-1.26). Positive associations were observed in small cell lung cancer (HR = 1.21, 95% CI = 1.10-1.33), lung adenocarcinoma (HR = 1.17, 95% CI = 1.11-1.23) and lung squamous cell carcinoma (HR = 1.22, 95% CI = 1.14-1.31). No genetical association of circulating CRP levels and lung cancer risk was observed in MR analysis. When added to a risk model of lung cancer, CRP improved the performance of model as long as 8 years among current smokers (basic model: C-statistic = 0.78 [95% CI = 0.75-0.80]; CRP model: C-statistic = 0.79 [95% CI = 0.76-0.81]; P  = .003, P  = .014). Our results did not support the causal association of circulating CRP with lung cancer risk. However, circulating CRP could be a prediagnostic marker of lung cancer as long as 8 years in advance for current smokers.
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http://dx.doi.org/10.1002/ijc.33780DOI Listing
August 2021

Red Emission Carbon Dots Prepared by 1,4-Diaminonaphthalene for Light-Emitting Diode Application and Metal Ion Detection.

Materials (Basel) 2021 Aug 20;14(16). Epub 2021 Aug 20.

Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, College of Materials Science and Engineering, Southwest Forestry University, Kunming 650224, China.

Carbon dots (CDs), as the most important type of carbon materials, have been widely used in many fields because of their unique fluorescence characteristics and excellent properties of biocompatibility. In previous studies, the fluorescence of CDs was mainly concentrated in the blue and green, whereas the red fluorescence was relatively less. Herein, we prepared efficient red-emitting CDs from 1,4-diaminonaphthalene using solvothermal methods. We discussed the effects of different solvothermal solvents on CDs. The results show that CDs prepared with octane and acetone as reaction media have the best fluorescence properties. The CDs dispersed in different organic solvents exhibited tunable emission across a wide spectrum from 427 nm to 679 nm. We further demonstrated the application of red light-emitting diode (LED) optoelectronics and fluorescence detection of Fe in aqueous solution.
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http://dx.doi.org/10.3390/ma14164716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398855PMC
August 2021

Practice of New Normal Lifestyles, Economic and Social Disruption, and Level of Happiness Among General Public in China in the Post-COVID-19 Era.

Risk Manag Healthc Policy 2021 16;14:3383-3393. Epub 2021 Aug 16.

Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, People's Republic of China.

Purpose: This study aimed to investigate the impact of the COVID-19 pandemic on the practice of 'new normal' lifestyles, economic and social distribution, and individuals' well-being of people in China after the country ease the lockdown restriction.

Methods: A cross-sectional, self-administered online survey was carried out between 3 September and 15 October 2020.

Results: A total of 8393 complete responses were received from a nationwide sample. Poor sustainability in the practice of "new norm" was reported. Noteworthy disparities were observed in willingness to carry out "new normal" practices by gender, urban-rural locality, non-Han and Han Chinese and educational attainment. There was evidence of economic and social disruption associated with COVID-19 or "new normal" practices. The current mean (±standard deviation [SD]) happiness score (110.45 ± 17.55) was slightly lower than the mean happiness score before (111.12 ± 17.83) the COVID-19 pandemic (t= -9.01, p<0.001). Lower socioeconomic status and greater economic and social disruptions were associated with lower current happiness scores. Moreover, greater willingness to adapt to "new normal" practices was associated with higher levels of happiness.

Conclusion: There is a need to encourage sustainable practice of new norm post-pandemic. Segments of the public continue to experience significant economic and social effects and the post-pandemic 'new norms' remain at risk of leading to psychological consequences.
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http://dx.doi.org/10.2147/RMHP.S320448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378895PMC
August 2021

Stabilizing P2-Type Ni-Mn Oxides as High-Voltage Cathodes by a Doping-Integrated Coating Strategy Based on Zinc for Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2021 Sep 24;13(34):40695-40704. Epub 2021 Aug 24.

Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.

The key to development of high-voltage P2-type NaNiMnO is the modification methods that can effectively improve its electrochemical reversibility. Herein, a doping-integrated coating strategy based on zinc element is proposed to modify P2-type NaNiMnO, which can be achieved by a facile one-step solid-state reaction. The formation mechanism of [email protected] ([email protected]) is investigated, revealing that the spinel and P3 intermediate phases appear prior to the formation of the P2 phase. Ni can be preferentially incorporated into the P2 structure in competition with Zn at high temperature, resulting in a uniform enrichment of ZnO on the surface. A small amount of Zn doping significantly suppresses the Na/vacancy ordering effect and improves the structural reversibility. Furthermore, the electrolyte decomposition is effectively reduced because of the presence of the ZnO coating layer, leading to the formation of a thin cathode electrolyte interphase film that is favorable to fast Na diffusion. In virtue of the Zn doping and in situ formed ZnO coating, [email protected] exhibits excellent cycling stability with a capacity retention of 83.7% after 100 cycles at 100 mA g and rate performance with a discharge capacity of 56.4 mAh g at 2000 mA g, which significantly outperforms the uncoated NaNiZnMnO and the NaNiZnMnO/0.06ZnO with the coating layer introduced by mechanical milling. This work provides a new strategy to design high-performance cathode materials for sodium-ion batteries.
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http://dx.doi.org/10.1021/acsami.1c12062DOI Listing
September 2021

Three-Dimensional-Printed Silica Aerogels for Thermal Insulation by Directly Writing Temperature-Induced Solidifiable Inks.

ACS Appl Mater Interfaces 2021 Sep 23;13(34):40964-40975. Epub 2021 Aug 23.

Science and Technology on Advanced Ceramic Fibers and Composites Laboratory, College of Aerospace Science and Engineering, National University of Defense Technology, 109 De Ya Rd, Changsha, Hunan 410073, P.R. China.

Silica aerogels are attractive materials for various applications due to their exceptional performances and open porous structure. Especially in thermal management, silica aerogels with low thermal conductivity need to be processed into customized structures and shapes for accurate installation on protected parts, which plays an important role in high-efficiency insulation. However, traditional subtractive manufacturing of silica aerogels with complex geometric architectures and high-precision shapes has remained challenging since the intrinsic ceramic brittleness of silica aerogels. Comparatively, additive manufacturing (3D printing) provides an alternative route to obtain custom-designed silica aerogels. Herein, we demonstrate a thermal-solidifying 3D printing strategy to fabricate silica aerogels with complex architectures via directly writing a temperature-induced solidifiable silica ink in an ambient environment. The solidification of silica inks is facilely realized, coupling with the continuous ammonia catalysis by the thermolysis of urea. Based on our proposed thermal-solidifying 3D printing strategy, printed objects show excellent shape retention and have a capacity to subsequently undergo the processes of in situ hydrophobic modification, solvent replacement, and supercritical drying. 3D-printed silica aerogels with hydrophobic modification show a super-high water contact angle of 157°. Benefiting from the low density (0.25 g·cm) and mesoporous silica network, optimized 3D-printed specimens with a high specific surface area of 272 m·g possess a low thermal conductivity of 32.43 mW·m·K. These outstanding performances of 3D-printed silica aerogels are comparable to those of traditional aerogels. More importantly, the thermal-solidifying 3D printing strategy brings hope to the custom design and industrial production of silica aerogel insulation materials.
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http://dx.doi.org/10.1021/acsami.1c12020DOI Listing
September 2021

Excessive Treadmill Training Produces different Cardiac-related MicroRNA Profiles in the Left and Right Ventricles in Mice.

Int J Sports Med 2021 Aug 20. Epub 2021 Aug 20.

The Research Center of Military Exercise Science, The Army Engineering University of PLA, Nanjing, China.

High-volume training followed by inadequate recovery may cause overtraining. This process may undermine the protective effect of regular exercise on the cardiovascular system and may increase the risk of pathological cardiac remodelling. We evaluated whether chronic overtraining changes cardiac-related microRNA profiles in the left and right ventricles. C57BL/6 mice were divided into the control, normal training, and overtrained by running without inclination, uphill running or downhill running groups. After an 8-week treadmill training protocol, the incremental load test and training volume results showed that the model had been successfully established. The qRT-PCR results showed increased cardiac miR-1, miR-133a, miR-133b, miR-206, miR-208b and miR-499 levels in the left ventricle of the downhill running group compared with the left ventricle of the control group. Similarly, compared with the control group, the downhill running induced increased expression of miR-21, miR-17-3p, and miR-29b in the left ventricle. Unlike the changes in the left ventricle, no difference in the expression of the tested miRNAs was observed in the right ventricle. Briefly, our results indicated that overtraining generally affects key miRNAs in the left ventricle (rather than the right ventricle) and that changes in individual miRNAs may cause either adaptive or maladaptive remodelling with overtraining.
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http://dx.doi.org/10.1055/a-1539-6702DOI Listing
August 2021

Review of recent findings on occurrence and fates of siloxanes in environmental compartments.

Ecotoxicol Environ Saf 2021 Aug 17;224:112631. Epub 2021 Aug 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Hubei Key Laboratory of Environmental and Health Effects of Persistence Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, China; School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 330106, China.

In view of their vast global usage in both consumer products and industrial processes, environmental emission and fates of siloxanes have become concerned issue. This review summarized the research progress, especially in the last decade, on production/consumption data, toxicities, analysis methods, environmental distribution, migration and degradation/transformation of both dimethylsiloxanes and modified siloxanes in atmospheric, aquatic and terrestrial compartments from various areas (especially in China). In spite of their fast degradation (hydrolysis and hydroxylation, etc) in various matrices (except sediment), dimethylsiloxane oligomers have been found in various environmental matrices from many countries due to their constant usage and emission. Moreover, recent literatures have paid attention to behaviors of dimethylsiloxanes in industrial areas, e.g., their higher residual levels compared with residential areas and unique transformed products (such as halogenated products) arose from special industrial production scenarios. Meanwhile, although most prior studies focused on dimethylsiloxanes, identification of modified-siloxanes with other functional groups in environment have been beginning to attract the attention of scientists. Furthermore, related literatures indicated that compared with dimethylsiloxanes, both halogenated-dimethylsiloxanes and modified methylsiloxanes (phenylsiloxanes and trifluoropropylsiloxanes) could have stronger persistence due to their weaker volatilization and degradation, especially in terrestrial matrices.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112631DOI Listing
August 2021

A Simple Model for Predicting 10-Year Cardiovascular Risk in Middle-Aged to Older Chinese: Guangzhou Biobank Cohort Study.

J Cardiovasc Transl Res 2021 Aug 16. Epub 2021 Aug 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

The aim of this paper is to develop 10-year cardiovascular disease (CVD) risk prediction models for the contemporary Chinese populations based on the Guangzhou Biobank Cohort Study (GBCS) and to compare its performance with models based on Framingham's general cardiovascular risk profile and the Prediction for Atherosclerotic CVD Risk in China (China-PAR) project. Subjects were randomly classified into the training (n = 15,000) and validation (n = 12,721) sets. During an average of 12.0 years' follow-up, 3,732 CVD events occurred. A 10-year sex-specific CVD risk prediction model including age, systolic blood pressure, use of antihypertensive medication, smoking, and diabetes was developed. Compared with the Framingham and China-PAR models, the GBCS model had a better discrimination in both women (c-statistic 0.72, 95% CI 0.71-0.73) and men (c-statistic 0.68, 95% CI 0.67-0.70), and the risk predicted was closer to the actual risk. This prediction model would be useful for identifying individuals at higher risks of CVD in contemporary Chinese populations.
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http://dx.doi.org/10.1007/s12265-021-10163-3DOI Listing
August 2021
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