Xose R Bustelo

Xose R Bustelo

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Xose R Bustelo

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The Vav GEF Family: An Evolutionary and Functional Perspective.

Cells 2019 05 16;8(5). Epub 2019 May 16.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain.

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http://dx.doi.org/10.3390/cells8050465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562523PMC
May 2019

RAS GTPase-dependent pathways in developmental diseases: old guys, new lads, and current challenges.

Curr Opin Cell Biol 2018 12 11;55:42-51. Epub 2018 Jul 11.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1016/j.ceb.2018.06.007DOI Listing
December 2018

Editorial overview: New concepts and experimental approaches to understand development, tissue regeneration, and human disease.

Curr Opin Cell Biol 2018 12 1;55:iii-v. Epub 2018 Oct 1.

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674183015
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http://dx.doi.org/10.1016/j.ceb.2018.09.006DOI Listing
December 2018

Protein-Protein Interactions: Emerging Oncotargets in the RAS-ERK Pathway.

Trends Cancer 2018 09 9;4(9):616-633. Epub 2018 Aug 9.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Cantabria, Santander 39011, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.07.002DOI Listing
September 2018

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation.

Nat Commun 2018 09 5;9(1):3595. Epub 2018 Sep 5.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Cantabria, Santander, 39011, Spain.

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http://dx.doi.org/10.1038/s41467-018-05941-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125387PMC
September 2018

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers.

J Cell Biol 2018 08 1;217(8):2813-2830. Epub 2018 Jun 1.

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA

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http://dx.doi.org/10.1083/jcb.201706041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080943PMC
August 2018

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges.

Authors:
Xosé R Bustelo

Biochem Soc Trans 2018 06 5;46(3):741-760. Epub 2018 Jun 5.

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, 37007 Salamanca, Spain

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http://dx.doi.org/10.1042/BST20170531DOI Listing
June 2018

New insights into the Vav1 activation cycle in lymphocytes.

Cell Signal 2018 05 2;45:132-144. Epub 2018 Feb 2.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, 37007 Salamanca, Spain; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, 37007 Salamanca, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, 37007 Salamanca, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.01.026DOI Listing
May 2018

Ribosome biogenesis and cancer: basic and translational challenges.

Curr Opin Genet Dev 2018 02 5;48:22-29. Epub 2017 Nov 5.

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, and Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain; Departamento de Bioquímica y Biología Molecular, University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.10.003DOI Listing
February 2018

An unexpected tumor suppressor role for VAV1.

Mol Cell Oncol 2018 23;5(3):e1432257. Epub 2018 Feb 23.

Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1080/23723556.2018.1432257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149884PMC
February 2018

Rho guanosine nucleotide exchange factors are not such bad guys after all in cancer.

Small GTPases 2018 Jan 24:1-7. Epub 2018 Jan 24.

a Centro de Investigación del Cáncer , CSIC-University of Salamanca , Salamanca , Spain.

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https://www.tandfonline.com/doi/full/10.1080/21541248.2018.1
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http://dx.doi.org/10.1080/21541248.2018.1423851DOI Listing
January 2018

Lung regeneration after toxic injury is improved in absence of dioxin receptor.

Stem Cell Res 2017 12 12;25:61-71. Epub 2017 Oct 12.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.10.009DOI Listing
December 2017

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Cancer Cell 2017 11;32(5):608-623.e9

Centro de Investigación del Cáncer, CSIC - University of Salamanca, 37007 Salamanca, Spain; Instituto de Biología Molecular y Celular del Cáncer, CSIC - University of Salamanca, 37007 Salamanca, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC - University of Salamanca, 37007 Salamanca, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691892PMC
November 2017

Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast.

RNA 2017 09 6;23(9):1432-1443. Epub 2017 Jun 6.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1261/rna.061259.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558912PMC
September 2017

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Cell Rep 2016 12;17(10):2572-2583

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177621PMC
December 2016

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.

Mol Cell Biol 2015 Oct 3;35(20):3528-46. Epub 2015 Aug 3.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Salamanca, Spain Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Salamanca, Spain

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http://dx.doi.org/10.1128/MCB.00518-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573708PMC
October 2015

The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.

Mol Biol Cell 2015 Aug 24;26(16):2895-912. Epub 2015 Jun 24.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, 37007 Salamanca, Spain

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https://www.molbiolcell.org/doi/10.1091/mbc.E15-01-0052
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http://dx.doi.org/10.1091/mbc.E15-01-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571328PMC
August 2015

Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.

Nat Neurosci 2015 Aug 6;18(8):1084-93. Epub 2015 Jul 6.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://www.csn.org.cn/2015/upload/20150804115149-.pdf
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http://www.nature.com/doifinder/10.1038/nn.4060
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http://dx.doi.org/10.1038/nn.4060DOI Listing
August 2015

Vav family exchange factors: an integrated regulatory and functional view.

Authors:
Xosé R Bustelo

Small GTPases 2014 ;5(2)

a Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer ; Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca ; Campus Unamuno; Salamanca , Spain.

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http://www.tandfonline.com/doi/full/10.4161/21541248.2014.97
Publisher Site
http://dx.doi.org/10.4161/21541248.2014.973757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601183PMC
July 2015

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.

Mol Cell Biol 2014 Dec 6;34(24):4404-19. Epub 2014 Oct 6.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain

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http://dx.doi.org/10.1128/MCB.01066-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248731PMC
December 2014

New avenue to inhibit Ras signaling.

Authors:
Xosé R Bustelo

Chem Biol 2014 Dec;21(12):1599-600

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain; Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas and University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.12.001DOI Listing
December 2014

Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output.

Mol Cell Biol 2014 Sep 30;34(18):3388-406. Epub 2014 Jun 30.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, Salamanca, Spain

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http://dx.doi.org/10.1128/MCB.00347-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135624PMC
September 2014

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.

Nat Commun 2014 May 14;5:3881. Epub 2014 May 14.

1] Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain [2] Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-University of Salamanca, Campus Unamuno s/n, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1038/ncomms4881DOI Listing
May 2014

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.

Sci Signal 2014 Apr 15;7(321):ra35. Epub 2014 Apr 15.

1Centro de Investigación del Cáncer, Campus Unamuno, E37007 Salamanca, Spain.

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http://dx.doi.org/10.1126/scisignal.2004993DOI Listing
April 2014

Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.

Cell Metab 2013 Aug;18(2):199-211

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas-University of Salamanca, Spain.

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http://dx.doi.org/10.1016/j.cmet.2013.07.001DOI Listing
August 2013

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

PLoS Biol 2013 Jul 23;11(7):e1001615. Epub 2013 Jul 23.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas-CSIC-University of Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1371/journal.pbio.1001615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720258PMC
July 2013

Rac-ing to the plasma membrane: the long and complex work commute of Rac1 during cell signaling.

Small GTPases 2012 Jan-Mar;3(1):60-6

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, Salamanca, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/sgtp.19111
Publisher Site
http://dx.doi.org/10.4161/sgtp.19111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398920PMC
April 2013

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein.

J Biol Chem 2013 Feb 20;288(6):3858-70. Epub 2012 Dec 20.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

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http://dx.doi.org/10.1074/jbc.M112.439810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567640PMC
February 2013

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

Sci Signal 2012 Oct 2;5(244):ra71. Epub 2012 Oct 2.

Centro de Investigación del Cáncer, CSIC-University of Salamanca, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1126/scisignal.2002962DOI Listing
October 2012

Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more.

Authors:
Xosé R Bustelo

Bioessays 2012 Sep 18;34(9):748-59. Epub 2012 Jun 18.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.

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http://dx.doi.org/10.1002/bies.201200041DOI Listing
September 2012

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.

Mol Biol Cell 2012 Jun 25;23(12):2373-87. Epub 2012 Apr 25.

Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas-University of Salamanca, E37007 Salamanca, Spain.

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http://www.molbiolcell.org/content/23/12/2373.full.pdf
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http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E12-01-0060
Publisher Site
http://dx.doi.org/10.1091/mbc.E12-01-0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374755PMC
June 2012

Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.

Mol Biol Cell 2010 Dec 6;21(23):4251-63. Epub 2010 Oct 6.

Centro de Investigación del Cáncer, CSIC-Salamanca University, Instituto de Neurociencias de Castilla y León and Departamento de Fisiología y Farmacología, Salamanca University, 37007 Salamanca, Spain.

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http://dx.doi.org/10.1091/mbc.E10-07-0639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993752PMC
December 2010

A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.

Authors:
Xosé R Bustelo

Small GTPases 2010 Jul;1(1):69-74

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer; CSIC-University of Salamanca; Campus Unamuno; Salamanca, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/sgtp.1.1.12986
Publisher Site
http://dx.doi.org/10.4161/sgtp.1.1.12986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109477PMC
July 2010

Vav3-deficient mice exhibit a transient delay in cerebellar development.

Mol Biol Cell 2010 Mar 20;21(6):1125-39. Epub 2010 Jan 20.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1091/mbc.e09-04-0292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836963PMC
March 2010

The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.

J Clin Invest 2010 Jan 14;120(1):315-30. Epub 2009 Dec 14.

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, Salamanca, Spain.

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http://dx.doi.org/10.1172/JCI38356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798677PMC
January 2010

The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.

PLoS One 2009 Dec 14;4(12):e8229. Epub 2009 Dec 14.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-University of Salamanca, Salamanca, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008229PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788417PMC
December 2009

Conformational rearrangements upon Syk auto-phosphorylation.

Biochim Biophys Acta 2009 Aug 3;1794(8):1211-7. Epub 2009 May 3.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Ramiro de Maeztu, Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbapap.2009.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746503PMC
August 2009

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

Nat Immunol 2009 Aug 28;10(8):880-8. Epub 2009 Jun 28.

Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Cantoblanco, Spain.

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http://www.nature.com/articles/ni.1749
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http://dx.doi.org/10.1038/ni.1749DOI Listing
August 2009

The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.

Mol Biol Cell 2009 Mar 21;20(6):1715-27. Epub 2009 Jan 21.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, 06071 Badajoz, Spain.

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http://dx.doi.org/10.1091/mbc.e08-05-0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655264PMC
March 2009

Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.

J Biol Chem 2008 Dec 29;283(52):36454-64. Epub 2008 Oct 29.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas, University of Salamanca, Campus Unamuno, Salamanca E-37007, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M803814200
Publisher Site
http://dx.doi.org/10.1074/jbc.M803814200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606015PMC
December 2008

Identification of the Rock-dependent transcriptome in rodent fibroblasts.

Clin Transl Oncol 2008 Nov;10(11):726-38

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC - University of Salamanca, Campus Unamuno, Salamanca, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737644PMC
November 2008

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.

J Clin Invest 2008 Jun;118(6):2169-79

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1172/JCI34385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2381749PMC
June 2008

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.

Cell Signal 2008 Apr 28;20(4):758-70. Epub 2007 Dec 28.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1016/j.cellsig.2007.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277368PMC
April 2008

CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling.

J Biol Chem 2008 Feb 26;283(9):5554-66. Epub 2007 Dec 26.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1074/jbc.M708566200DOI Listing
February 2008

Human Proteinpedia enables sharing of human protein data.

Authors:
Suresh Mathivanan Mukhtar Ahmed Natalie G Ahn Hainard Alexandre Ramars Amanchy Philip C Andrews Joel S Bader Brian M Balgley Marcus Bantscheff Keiryn L Bennett Erik Björling Blagoy Blagoev Ron Bose Samir K Brahmachari Alma S Burlingame Xosé R Bustelo Gerard Cagney Greg T Cantin Helene L Cardasis Julio E Celis Raghothama Chaerkady Feixia Chu Philip A Cole Catherine E Costello Robert J Cotter David Crockett James P DeLany Angelo M De Marzo Leroi V DeSouza Eric W Deutsch Eric Dransfield Gerard Drewes Arnaud Droit Michael J Dunn Kojo Elenitoba-Johnson Rob M Ewing Jennifer Van Eyk Vitor Faca Jayson Falkner Xiangming Fang Catherine Fenselau Daniel Figeys Pierre Gagné Cecilia Gelfi Kris Gevaert Jeffrey M Gimble Florian Gnad Renu Goel Pavel Gromov Samir M Hanash William S Hancock H C Harsha Gerald Hart Faith Hays Fuchu He Prashantha Hebbar Kenny Helsens Heiko Hermeking Winston Hide Karin Hjernø Denis F Hochstrasser Oliver Hofmann David M Horn Ralph H Hruban Nieves Ibarrola Peter James Ole N Jensen Pia Hønnerup Jensen Peter Jung Kumaran Kandasamy Indu Kheterpal Reiko F Kikuno Ulrike Korf Roman Körner Bernhard Kuster Min-Seok Kwon Hyoung-Joo Lee Young-Jin Lee Michael Lefevre Minna Lehvaslaiho Pierre Lescuyer Fredrik Levander Megan S Lim Christian Löbke Joseph A Loo Matthias Mann Lennart Martens Juan Martinez-Heredia Mark McComb James McRedmond Alexander Mehrle Rajasree Menon Christine A Miller Harald Mischak S Sujatha Mohan Riaz Mohmood Henrik Molina Michael F Moran James D Morgan Robert Moritz Martine Morzel David C Muddiman Anuradha Nalli J Daniel Navarro Thomas A Neubert Osamu Ohara Rafael Oliva Gilbert S Omenn Masaaki Oyama Young-Ki Paik Kyla Pennington Rainer Pepperkok Balamurugan Periaswamy Emanuel F Petricoin Guy G Poirier T S Keshava Prasad Samuel O Purvine B Abdul Rahiman Prasanna Ramachandran Y L Ramachandra Robert H Rice Jens Rick Ragna H Ronnholm Johanna Salonen Jean-Charles Sanchez Thierry Sayd Beerelli Seshi Kripa Shankari Shi Jun Sheng Vivekananda Shetty K Shivakumar Richard J Simpson Ravi Sirdeshmukh K W Michael Siu Jeffrey C Smith Richard D Smith David J States Sumio Sugano Matthew Sullivan Giulio Superti-Furga Maarit Takatalo Visith Thongboonkerd Jonathan C Trinidad Mathias Uhlen Joël Vandekerckhove Julian Vasilescu Timothy D Veenstra José-Manuel Vidal-Taboada Mauno Vihinen Robin Wait Xiaoyue Wang Stefan Wiemann Billy Wu Tao Xu John R Yates Jun Zhong Ming Zhou Yunping Zhu Petra Zurbig Akhilesh Pandey

Nat Biotechnol 2008 Feb;26(2):164-7

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http://dx.doi.org/10.1038/nbt0208-164DOI Listing
February 2008

RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.

Mol Cell Biol 2007 Dec 8;27(23):8127-42. Epub 2007 Oct 8.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00912-07
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http://dx.doi.org/10.1128/MCB.00912-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169177PMC
December 2007

3D structure of Syk kinase determined by single-particle electron microscopy.

Biochim Biophys Acta 2007 Dec 26;1774(12):1493-9. Epub 2007 Oct 26.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (Spanish National Research Council, CSIC), Ramiro de Maeztu, 9, E28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbapap.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186377PMC
December 2007

Transcriptomal profiling of site-specific Ras signals.

Cell Signal 2007 Nov 4;19(11):2264-76. Epub 2007 Jul 4.

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas (CSIC), Departamento de Biología Molecular, Unidad de Biomedicina, CSIC-Universidad de Cantabria, Santander, Spain.

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http://dx.doi.org/10.1016/j.cellsig.2007.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2085357PMC
November 2007

The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

Mol Cell Biol 2007 Aug 21;27(15):5414-29. Epub 2007 May 21.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://mcb.asm.org/content/27/15/5414.full.pdf
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http://mcb.asm.org/cgi/doi/10.1128/MCB.00380-07
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http://dx.doi.org/10.1128/MCB.00380-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952102PMC
August 2007

Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

Carcinogenesis 2007 Jun 18;28(6):1145-52. Epub 2007 Jan 18.

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgm008DOI Listing
June 2007

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.

Bioessays 2007 Apr;29(4):356-70

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain.

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http://doi.wiley.com/10.1002/bies.20558
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http://dx.doi.org/10.1002/bies.20558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971132PMC
April 2007

Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

Mol Cell Biol 2007 Mar 28;27(5):1745-57. Epub 2006 Dec 28.

Unitat de Biofísica, Departament Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.

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http://dx.doi.org/10.1128/MCB.01974-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820477PMC
March 2007

Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice.

Mol Biol Cell 2007 Mar 3;18(3):943-52. Epub 2007 Jan 3.

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1091/mbc.e06-09-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805112PMC
March 2007

Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction.

Nat Med 2006 Jul 11;12(7):841-5. Epub 2006 Jun 11.

Centro de Investigación del Cáncer, University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1038/nm1426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1997289PMC
July 2006

Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion.

Cancer Res 2006 Jan;66(1):248-58

Department of Immunology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952211PMC
January 2006

Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.

Exp Cell Res 2005 Aug;308(2):364-80

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1016/j.yexcr.2005.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447607PMC
August 2005

Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1.

Mol Biol Cell 2005 Jul 4;16(7):3223-35. Epub 2005 May 4.

Department of Immunology, Centro de Investigaciones Biológicas, CSIC, 28006 Madrid, Spain.

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http://dx.doi.org/10.1091/mbc.e04-12-1049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1165406PMC
July 2005

Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle.

J Biol Chem 2004 Sep 30;279(36):37385-97. Epub 2004 Jun 30.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca-CSIC, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1074/jbc.M404909200DOI Listing
September 2004

Inverted signaling hierarchy between RAS and RAC in T-lymphocytes.

Oncogene 2004 Jul;23(34):5823-33

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca-CSIC, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1038/sj.onc.1207768DOI Listing
July 2004

F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

J Biol Chem 2004 May 26;279(19):20435-46. Epub 2004 Feb 26.

Centro de Investigación del Cáncer, University of Salamanca-Consejo Superior de Investigaciones Cientiíficas, Campus Unamuno, E-37007 Salamanca, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M313013200
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http://dx.doi.org/10.1074/jbc.M313013200DOI Listing
May 2004

Structural basis for the signaling specificity of RhoG and Rac1 GTPases.

J Biol Chem 2003 Sep 12;278(39):37916-25. Epub 2003 Jun 12.

Centro de Investigación del Cáncer, University of Salamanca-Consejo Superior de Investigaciones Científicas, Campus Unamuno, Salamanca E-37007, Spain.

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http://dx.doi.org/10.1074/jbc.M301437200DOI Listing
September 2003

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

J Biol Chem 2003 Sep 16;278(36):34339-46. Epub 2003 Jun 16.

Oral and Pharyngeal Cancer Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302960200
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http://dx.doi.org/10.1074/jbc.M302960200DOI Listing
September 2003

Exchange factors of the RasGRP family mediate Ras activation in the Golgi.

J Biol Chem 2003 Aug 2;278(35):33465-73. Epub 2003 Jun 2.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca, Consejo Superior de Investigaciones Científicas, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1074/jbc.M302807200DOI Listing
August 2003

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.

EMBO J 2003 Jul;22(13):3326-36

Centro de Investigación del Cáncer, University of Salamanca-CSIC, Campus Unamuno, E-37007 Salamanca and Instituto de Investigaciones Biomédicas Alberto Sols, E-28929 Madrid, Spain.

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http://dx.doi.org/10.1093/emboj/cdg316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165641PMC
July 2003

Structural determinants for the biological activity of Vav proteins.

J Biol Chem 2002 Nov 12;277(47):45377-92. Epub 2002 Sep 12.

Centro de Investigación del Cáncer and Instituto de Biologia Molecular y Celular del Cáncer, CSIC-University of Salamanca, Campus Unamuno, E-37007 Salamanca, Spain.

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http://dx.doi.org/10.1074/jbc.M208039200DOI Listing
November 2002

Walking pathways at Heidelberg. Conference on oncogenes and growth control.

EMBO Rep 2002 Nov;3(11):1023-8

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca-CSIC, Campus Unamuno, E-37007 Salamanca, Spain.

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http://embor.embopress.org/cgi/doi/10.1093/embo-reports/kvf2
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http://dx.doi.org/10.1093/embo-reports/kvf223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307592PMC
November 2002

Understanding Rho/Rac biology in T-cells using animal models.

Authors:
Xosé R Bustelo

Bioessays 2002 Jul;24(7):602-12

Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca-CSIC. 37007 Salamanca, Spain.

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http://doi.wiley.com/10.1002/bies.10107
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http://dx.doi.org/10.1002/bies.10107DOI Listing
July 2002

Regulation of Vav proteins by intramolecular events.

Authors:
Xosé R Bustelo

Front Biosci 2002 Jan 1;7:d24-30. Epub 2002 Jan 1.

Centro de Investigacion del Cáncer and Instituto de Biologia Molecular y Celular del Cáncer. University of Salamanca-CSIC. 37007 Salamanca, Spain.

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January 2002