Xiwei Wu

Xiwei Wu

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Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting.

Mol Ther Oncolytics 2019 Sep 17;14:149-158. Epub 2019 May 17.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.omto.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562366PMC
September 2019

Modeling and sliding mode-based attitude tracking control of a quadrotor UAV with time-varying mass.

ISA Trans 2019 Aug 17. Epub 2019 Aug 17.

School of Automation, Northwestern Polytechnical University, Xi'an 710072, China. Electronic address:

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http://dx.doi.org/10.1016/j.isatra.2019.08.017DOI Listing
August 2019

Chemotherapy-Induced Extracellular Vesicle miRNAs Promote Breast Cancer Stemness by Targeting .

Cancer Res 2019 Jul 22;79(14):3608-3621. Epub 2019 May 22.

Department of Pathology, University of California, San Diego; La Jolla, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-4055DOI Listing
July 2019

An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma.

Mol Ther Nucleic Acids 2019 Mar 1;14:131-141. Epub 2018 Dec 1.

Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307106PMC
March 2019

SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study.

PLoS One 2018 21;13(6):e0198625. Epub 2018 Jun 21.

Department of Molecular Imaging and Therapy, Beckman Research Institute, City of Hope, Duarte, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013222PMC
December 2018

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Cell Stem Cell 2018 09 23;23(3):355-369.e9. Epub 2018 Aug 23.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143172PMC
September 2018

Alternative RNA Splicing Associated With Mammalian Neuronal Differentiation.

Cereb Cortex 2018 08;28(8):2810-2816

Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA, USA.

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https://academic.oup.com/cercor/article/28/8/2810/3885825
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http://dx.doi.org/10.1093/cercor/bhx160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041894PMC
August 2018

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.

EMBO J 2018 07 17;37(14). Epub 2018 May 17.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA

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http://dx.doi.org/10.15252/embj.201796729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043852PMC
July 2018

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.

Nat Commun 2018 07 13;9(1):2707. Epub 2018 Jul 13.

Department of Developmental and Stem Cell Biology, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1038/s41467-018-05152-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045631PMC
July 2018

Exosomal miRNAs species in the blood of small cell and non-small cell lung cancer patients.

Oncotarget 2018 Apr 13;9(28):19793-19806. Epub 2018 Apr 13.

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.24857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929426PMC
April 2018

Identification of core aberrantly expressed microRNAs in serous ovarian carcinoma.

Oncotarget 2018 Apr 17;9(29):20451-20466. Epub 2018 Apr 17.

Bioinformatics Core, Beckman Research Institute, City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.18632/oncotarget.24942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945511PMC
April 2018

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells.

Nat Commun 2017 11 13;8(1):1467. Epub 2017 Nov 13.

Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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http://www.nature.com/articles/s41467-017-01629-7
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http://dx.doi.org/10.1038/s41467-017-01629-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684340PMC
November 2017

SAIC: an iterative clustering approach for analysis of single cell RNA-seq data.

BMC Genomics 2017 Oct 3;18(Suppl 6):689. Epub 2017 Oct 3.

Integrative Genomics Core, Beckman Research Institute, City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1186/s12864-017-4019-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629617PMC
October 2017

Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network.

Cancer Genet 2017 Oct 17;216-217:111-119. Epub 2017 Aug 17.

Division of Clinical Cancer Genomics, City of Hope National Medical Center, 1500 E. Duarte Rd., Bldg 173, Duarte, CA 91010; Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010.

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http://dx.doi.org/10.1016/j.cancergen.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659836PMC
October 2017

Extrafollicular CD4 T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nat Commun 2017 10 17;8(1):978. Epub 2017 Oct 17.

Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1038/s41467-017-00880-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645449PMC
October 2017

Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas.

PLoS One 2017 27;12(6):e0179692. Epub 2017 Jun 27.

Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179692PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487038PMC
September 2017

Dynamics of RNA Polymerase II Pausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development.

Cell Rep 2017 08;20(6):1307-1318

Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564459PMC
August 2017

Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages.

PLoS One 2016 9;11(12):e0165118. Epub 2016 Dec 9.

Division of Neurosurgery, City of Hope Beckman Research Institute, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165118PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147798PMC
July 2017

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

Cancer Cell 2017 07;32(1):115-128.e7

Molecular and Cellular Biology of Cancer Program & Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173025
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http://dx.doi.org/10.1016/j.ccell.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552197PMC
July 2017

Vitamin K epoxide reductase regulation of androgen receptor activity.

Oncotarget 2017 Feb;8(8):13818-13831

Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.14639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355141PMC
February 2017

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.

FASEB J 2017 01 30;31(1):132-147. Epub 2016 Sep 30.

Department of Cancer Genetics and Epigenetics and Beckman Research Institute of City of Hope, Duarte, California, USA;

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http://www.fasebj.org/doi/10.1096/fj.201600631R
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http://dx.doi.org/10.1096/fj.201600631RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161519PMC
January 2017

Gene Expression Differences in Prostate Cancers between Young and Old Men.

PLoS Genet 2016 Dec 27;12(12):e1006477. Epub 2016 Dec 27.

Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189936PMC
December 2016

Circulating miRNA profile in esophageal adenocarcinoma.

Am J Cancer Res 2016 1;6(11):2713-2721. Epub 2016 Nov 1.

Division of Thoracic Surgery, City of Hope National Medical Center Duarte, California 91010, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126285PMC
November 2016

L-MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells.

Stem Cell Reports 2016 09 18;7(3):483-495. Epub 2016 Aug 18.

Department of Developmental and Stem Cell Biology, City of Hope National Medical Center and Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031988PMC
September 2016

High throughput sequencing analysis of RNA libraries reveals the influences of initial library and PCR methods on SELEX efficiency.

Sci Rep 2016 Sep 22;6:33697. Epub 2016 Sep 22.

Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1038/srep33697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031971PMC
September 2016

Prospective separation and transcriptome analyses of cortical projection neurons and interneurons based on lineage tracing by Tbr2 (Eomes)-GFP/Dcx-mRFP reporters.

Dev Neurobiol 2016 Jun 17;76(6):587-99. Epub 2015 Aug 17.

Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California, 91010.

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http://dx.doi.org/10.1002/dneu.22332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744584PMC
June 2016

Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1.

Cancer Res 2016 05 15;76(9):2824-35. Epub 2016 Mar 15.

Department of Biology, Beckman Research Institute, City of Hope, Duarte, California. Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873365PMC
May 2016

Cross-kingdom inhibition of breast cancer growth by plant miR159.

Cell Res 2016 Feb 22;26(2):217-28. Epub 2016 Jan 22.

Department of Cancer Biology, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1038/cr.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746606PMC
February 2016

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.

Nat Commun 2016 Feb 3;7:10637. Epub 2016 Feb 3.

Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, California 91010, USA.

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http://dx.doi.org/10.1038/ncomms10637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742843PMC
February 2016

Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".

EBioMedicine 2016 Feb 19;4:74-85. Epub 2016 Jan 19.

Department of Diabetes Complications and Metabolism, Duarte, CA 91010, USA; Beckman Research Institute at City of Hope National Medical Center, Duarte, CA 91010, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964163001
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http://dx.doi.org/10.1016/j.ebiom.2016.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776252PMC
February 2016

Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.

Cell Rep 2016 Jan 7;14(3):493-505. Epub 2016 Jan 7.

Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731272PMC
January 2016

Detection on emamectin benzoate-induced apoptosis and DNA damage in Spodoptera frugiperda Sf-9 cell line.

Pestic Biochem Physiol 2016 Jan 6;126:6-12. Epub 2015 Jul 6.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

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http://dx.doi.org/10.1016/j.pestbp.2015.06.009DOI Listing
January 2016

The DNA methylation landscape of human melanoma.

Genomics 2015 Dec 15;106(6):322-30. Epub 2015 Sep 15.

Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA; Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygeno.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666751PMC
December 2015

Property of midgut α-amylase from Mythimna separata (Lepidoptera: Noctuidae) larvae and its responses to potential inhibitors in vitro.

J Insect Sci 2014 1;14. Epub 2014 Jan 1.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China.

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http://dx.doi.org/10.1093/jisesa/ieu144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657837PMC
August 2015

Single base resolution analysis of 5-methylcytosine and 5-hydroxymethylcytosine by RRBS and TAB-RRBS.

Methods Mol Biol 2015 ;1238:273-87

Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA,

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http://dx.doi.org/10.1007/978-1-4939-1804-1_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340590PMC
July 2015

Comparison of the cytotoxic impact of chlorfluazuron on selected insect and human cell lines.

Environ Toxicol Chem 2015 Jul 14;34(7):1675-82. Epub 2015 May 14.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1002/etc.2969DOI Listing
July 2015

Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides.

Environ Toxicol Pharmacol 2015 Mar 31;39(2):677-82. Epub 2014 Dec 31.

Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:

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http://dx.doi.org/10.1016/j.etap.2014.12.015DOI Listing
March 2015

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

Nat Biotechnol 2015 Feb 19;33(2):175-8. Epub 2015 Jan 19.

Department of Virology, Beckman Research Institute of City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1038/nbt.3127DOI Listing
February 2015

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.

Nat Cell Biol 2015 Feb 26;17(2):183-94. Epub 2015 Jan 26.

1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

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http://dx.doi.org/10.1038/ncb3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380143PMC
February 2015

Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.

Diabetes 2014 Dec 9;63(12):4249-61. Epub 2014 Jul 9.

Department of Diabetes and Division of Molecular Diabetes Research, Beckman Research Institute of City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/db14-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238007PMC
December 2014

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis.

Genet Med 2014 Oct 24;16(10):787-92. Epub 2014 Apr 24.

1] Department of Molecular Pharmacology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA [2] PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/gim.2014.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189385PMC
October 2014

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer.

Nanomedicine 2014 Oct 22;10(7):1477-86. Epub 2014 Apr 22.

Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, CA, USA; Institute of Translational Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2014.04.003DOI Listing
October 2014

Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin.

Stem Cells Transl Med 2014 Oct 8;3(10):1199-208. Epub 2014 Aug 8.

Shared Resources-Cellular Process, City of Hope, Duarte, California, USA; Center for Blood Cell Therapies at Peter McCallum Center, Melbourne, Australia; Departments of Molecular and Cellular Biology and Virology, City of Hope, Duarte, California, USA

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http://dx.doi.org/10.5966/sctm.2014-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181393PMC
October 2014

Detailed comparison of two popular variant calling packages for exome and targeted exon studies.

PeerJ 2014 30;2:e600. Epub 2014 Sep 30.

Integrative Genomics Core, Department of Molecular and Cellular Biology, City of Hope National Medical Center , Duarte, CA , USA.

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http://dx.doi.org/10.7717/peerj.600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184249PMC
October 2014

ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance.

PLoS Genet 2014 Jun 26;10(6):e1004414. Epub 2014 Jun 26.

Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072521PMC
June 2014

Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.

Diabetes 2014 May 23;63(5):1748-62. Epub 2014 Jan 23.

Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA.

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http://dx.doi.org/10.2337/db13-1251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994951PMC
May 2014

Mutants TP53 p.R273H and p.R273C but not p.R273G enhance cancer cell malignancy.

Hum Mutat 2014 May 7;35(5):575-84. Epub 2014 Apr 7.

Department of Laboratory Medicine, M.O.E. Key Laboratory of Laboratory Medicine Diagnostics, Chongqing Medical University, Chongqing, 400016, P. R. China.

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http://dx.doi.org/10.1002/humu.22528DOI Listing
May 2014

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA.

Clin Cancer Res 2014 Mar 14;20(5):1179-89. Epub 2014 Jan 14.

Authors' Affiliations: Department of Molecular Pharmacology; Solexa Core Lab; Division of Information Sciences, Department of Molecular Medicine; Department of Pathology; Translational Research Laboratory, Beckman Research Institute, City of Hope National Medical Center, Duarte, California; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital; Pediatric Neurosurgery, Department of Surgery, Cheng Hsin General Hospital; and Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1452DOI Listing
March 2014

Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing.

Nucleic Acids Res 2014 Feb 11;42(3):1772-83. Epub 2013 Nov 11.

Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA, Eugene and Ruth Roberts Summer Academy, City of Hope National Medical Center, Duarte, CA 91010, USA and Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gkt1042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919614PMC
February 2014

UVB irradiation does not directly induce detectable changes of DNA methylation in human keratinocytes.

F1000Res 2013 13;2:45. Epub 2013 Feb 13.

Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, 91010, USA.

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http://dx.doi.org/10.12688/f1000research.2-45.v1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901454PMC
February 2014

Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants.

Nucleic Acids Res 2013 Jul 24;41(12):6209-21. Epub 2013 Apr 24.

Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA.

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http://nar.oxfordjournals.org/content/early/2013/04/24/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkt200
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http://dx.doi.org/10.1093/nar/gkt200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695504PMC
July 2013

Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication.

Lung Cancer 2013 Jul 29;81(1):27-31. Epub 2013 Apr 29.

Department of Respiratory Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.

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http://dx.doi.org/10.1016/j.lungcan.2013.04.006DOI Listing
July 2013

De novo DNA methylation in the male germ line occurs by default but is excluded at sites of H3K4 methylation.

Cell Rep 2013 Jul 27;4(1):205-19. Epub 2013 Jun 27.

Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740941PMC
July 2013

Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cells.

PLoS One 2012 14;7(9):e44858. Epub 2012 Sep 14.

Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044858PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443085PMC
February 2013

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

Cancer Res 2013 Feb 7;73(4):1298-307. Epub 2013 Feb 7.

Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2086DOI Listing
February 2013

Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.

Cell Rep 2013 Feb 9;3(2):291-300. Epub 2013 Feb 9.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582786PMC
February 2013

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization.

Nucleic Acids Res 2013 Jan 11;41(1):182-95. Epub 2012 Nov 11.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gks1051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592471PMC
January 2013

Oxidized low-density lipoprotein antigen transport induces autoimmunity in the renal tubulointerstitium.

Am J Nephrol 2012 25;35(6):520-30. Epub 2012 May 25.

Harbor-UCLA Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA.

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https://www.karger.com/Article/FullText/338484
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http://dx.doi.org/10.1159/000338484DOI Listing
November 2012

Whole DNA methylome profiling in mice exposed to secondhand smoke.

Epigenetics 2012 Nov 10;7(11):1302-14. Epub 2012 Oct 10.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.4161/epi.22453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499331PMC
November 2012

Epigenetic stability, adaptability, and reversibility in human embryonic stem cells.

Proc Natl Acad Sci U S A 2012 Jul 16;109(31):12544-9. Epub 2012 Jul 16.

Department of Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1073/pnas.1209620109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411986PMC
July 2012

Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes.

J Biol Chem 2012 May 19;287(20):16335-45. Epub 2012 Mar 19.

Department of Diabetes and Bioinformatics Core, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M111.330373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351309PMC
May 2012

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.

Nat Commun 2012 May 8;3:815. Epub 2012 May 8.

Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA.

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http://www.nature.com/articles/ncomms1825
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http://dx.doi.org/10.1038/ncomms1825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517178PMC
May 2012

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs.

Mol Ther Nucleic Acids 2012 Apr 3;1:e17. Epub 2012 Apr 3.

Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1038/mtna.2012.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384246PMC
April 2012