Publications by authors named "Xiuyu Huang"

6 Publications

  • Page 1 of 1

A calcium phosphate drug carrier loading with 5-fluorouracil achieving a synergistic effect for pancreatic cancer therapy.

J Colloid Interface Sci 2021 Jul 20;605:263-273. Epub 2021 Jul 20.

The Seventh Hospital of Sun Yat-sen University, Sun Yat-sen University, Shenzhen 518107, China. Electronic address:

Calcium based biomaterials were widely used for drug delivery application due to their biodegradability, biocompatibility, and high drug loading capacity. Herein, amino-capped polyamidoamine (PAMAM) dendrimer was applied as a macromolecular template to form amino-modified calcium phosphate hollow sphere (CaPO-NH). After loading with 5-fluorouracil (5Fu), this system performed synergistic cancer chemotherapy. In this study, the 5Fu/CaPO-NH particles could be efficiently uptaken by cancer cells, and then decompose into Ca and release 5Fu drug in the cytoplasm; therefore calcium overload and reactive oxygen species (ROS) accumulation were found in PSN1 cells that could induce cell membrane damage and elicit cell apoptosis through a series of biochemical reactions including endoplasmic reticulum stress, lipid peroxidation and mitochondrial apoptosis. In the PSN1 pancreatic cancer xenograft model, the 5Fu/CaPO-NH system performed high tumor inhibition via chemotherapy and calcium overload induced apoptosis. Comparingly, the normal cells and organs were insensitive to this synergistic therapy, which indicated the well biocompatibility of delivery system. Thus, this study provided a promising CaPO-NH drug delivery platform for enhanced 5Fu chemotherapeutic effect.
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http://dx.doi.org/10.1016/j.jcis.2021.07.080DOI Listing
July 2021

Social Support and Academic Burnout Among University Students: A Moderated Mediation Model.

Psychol Res Behav Manag 2021 18;14:335-344. Epub 2021 Mar 18.

Department of Physical Education, Shaanxi Normal University, Xi'an, People's Republic of China.

Purpose: An increasing number of studies have been carried out to investigate the relationship between social support and study motivation among university students, but underlying mechanisms behind this pathway have not been fully verified. In the present study, we aimed to test the effect of social support on academic burnout (decrease in study motivation); examine the mediating effect of life satisfaction on the association between social support and academic burnout; and explore whether this mediating effect varied across (moderated mediation) students of different socioeconomic status (SES).

Materials And Methods: Data for 503 students were collected in a Chinese university through a composited survey regarding social support, life satisfaction, SES, and academic burnout. Data analysis and the investigation of combined effects in the model were carried out via conditional process modeling.

Results: Results indicated that social support was negatively associated with academic burnout. In addition, life satisfaction had a partial mediation effect on the relationship between social support and academic burnout, and SES moderated this mediation effect. Specifically, the mediation effect was found to be more significant among students in the high SES group than those in the lower one.

Conclusion: This study is novel in that it establishes empirically how academic burnout is associated with a typical society analytical variable (ie, social support) among students in tertiary education. It also investigates an alternative scenario to explain the underlying mechanism of social support on academic burnout against the most popular explaining model. Implications of the study for effective elimination of the decrease in study motivation across students with different SES are discussed.
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http://dx.doi.org/10.2147/PRBM.S300797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987309PMC
March 2021

Mesenchymal stem cells: current clinical progress in ARDS and COVID-19.

Stem Cell Res Ther 2020 07 22;11(1):305. Epub 2020 Jul 22.

Department of Pulmonary and Critical Care Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restricted fluid input, and there is no suggested pharmacological treatment. Mesenchymal stromal cells (MSCs) have been reported to be promising treatments for lung diseases. MSCs have been shown to have a number of protective effects in some animal models of ARDS by releasing soluble, biologically active factors. In this review, we will focus on clinical progress in the use of MSCs as a cell therapy for ARDS, which may have clinical implications during the coronavirus disease 2019 (COVID-19) pandemic.
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http://dx.doi.org/10.1186/s13287-020-01804-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373844PMC
July 2020

Multiple Plasmid Vectors Mediate the Spread of in Extended-Spectrum-β-Lactamase-Producing Isolates from Retail Vegetables in China.

mSphere 2020 07 15;5(4). Epub 2020 Jul 15.

College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

The plasmid-mediated fosfomycin resistance gene has been detected in from various sources but has rarely been reported in vegetables. In this study, the aim was to investigate the prevalence of and, subsequently, to characterize -positive isolates from retail vegetables. Seventeen (7.3%) -carrying strains were identified from 233 extended-spectrum-β-lactamase-producing isolates from vegetables. All 17 isolates, including six , seven , two , and two isolates, carried S1-nuclease pulsed-field gel electrophoresis (S1-PFGE) and hybridization confirmed that the genes in 16 isolates were located on plasmids ranging in size from ∼40 kb to ∼250 kb, except one located on chromosome of All the carrying plasmids from 16 -positive isolates were successfully transferred into the recipient bacteria by transformation or conjugation. In agreement with data determined with isolates from food animals, the IncHI2/ST3 and IncN-F33:A-:B-/F33:A-:B plasmids were the main vectors of in Additionally, F24:A-:B1, IncFII-IncR, IncFII, IncR, and two untypeable plasmids were found for the first time to be vectors for in The genetic contexts of in 15 isolates differed due to insertion and/or loss of molecular modules mediated by mobile elements. However, all genes were flanked by IS, as commonly observed in other -carrying plasmids. Here, we report a high rate of detection of genes, mediated by multiple plasmid vectors, in ESBL-producing from retail vegetables. FosA3-producing could be transmitted to the human body by direct contact or consumption of vegetables, which might pose a potential threat to public health. This report provides important information on the transmission and epidemiology of among isolates from vegetables. The rate of occurrence of in ESBL-producing from retail vegetables is high, and was found to be carried by diverse plasmids. Some novel genetic contexts of and novel -carrying plasmids, including several plasmid types common in , were identified, increasing the number of known transfer vectors for the gene and reflecting the complexity of transmission in The capture of by the resident plasmid of will accelerate the spread of in , one of the most pathogenic species in clinical medicine. Considering the clinical importance of fosfomycin, and the fact that vegetables are directly consumed, the fosfomycin resistance genes present a risk of transmission to the human body through the food chain and thus pose a threat to public health.
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http://dx.doi.org/10.1128/mSphere.00507-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364219PMC
July 2020

Rapid Increase in Carbapenemase-Producing Enterobacteriaceae in Retail Meat Driven by the Spread of the -Carrying IncX3 Plasmid in China from 2016 to 2018.

Antimicrob Agents Chemother 2019 08 25;63(8). Epub 2019 Jul 25.

College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South China Agricultural University, Guangzhou, China

The presence and molecular characteristics of carbapenemase-producing (CPE) among meat products in China were investigated. A total of 110 carbapenem-resistant (CRE) isolates, including 94 and 10 isolates, were identified from 105 of 794 (13.2%) samples. The positive rates markedly increased from 2016 (9.4%) to 2018 (22.2%). Only genes were detected; 79.1% of genes were carried by IncX3 plasmids. Routine monitoring of carbapenemase-producing in the animal food supply is highly recommended.
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http://dx.doi.org/10.1128/AAC.00573-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658802PMC
August 2019

Emergence of in Raoultella ornithinolytica and Escherichia coli Isolates from Retail Vegetables in China.

Antimicrob Agents Chemother 2017 10 22;61(10). Epub 2017 Sep 22.

College of Veterinary Medicine, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, Guangdong, China

The presence of among isolates collected from retail vegetables in China between 2015 and 2016 was investigated. Two and seven strains recovered from lettuce and tomato samples were identified as MCR-1-producers. Similar to isolates from animals and humans, the gene was located on the IncHI2/ST3, IncI2, or IncX4 plasmids. The presence of MCR-1-producing organisms in ready-to-eat food samples represents a serious risk for human health.
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http://dx.doi.org/10.1128/AAC.01139-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610531PMC
October 2017
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