Publications by authors named "Xiuling Zhang"

83 Publications

Racial Disparities in Children, Adolescents, and Young Adults with Hodgkin Lymphoma Enrolled in the New York State Medicaid Program.

J Adolesc Young Adult Oncol 2021 Oct 8. Epub 2021 Oct 8.

Center for Oncology Hematology Outcomes Research and Training (COHORT) and Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento, California, USA.

We examined the impact of race/ethnicity and age on survival in a publicly insured cohort of children and adolescent/young adults (AYA; 15-39 years) with Hodgkin lymphoma, adjusting for chemotherapy using linked Medicaid claims. We identified 1231 Medicaid-insured patients <1-39 years diagnosed with classical Hodgkin lymphoma between 2005 and 2015, in the New York State Cancer Registry. Chemotherapy regimens were based on contemporary therapeutic regimens. Cox proportional hazards regression models quantified associations of patient, disease, and treatment variables with overall survival (OS) and disease-specific survival (DSS), and are presented as hazard ratios (HR) with confidence intervals (95% CIs). At median follow-up of 6.6 years,  = 1108 (90%) patients were alive; 5-year OS was 92% in children <15 years. In multivariable models, Black (vs. White) patients had 1.6-fold increased risk of death (HR: 1.58, 95% CI: 1.02-2.46;  = 0.042). Stage III/IV (vs. I/II) was associated with 1.9-fold increased risk of death (HR: 1.86, 95% CI: 1.25-2.78;  = 0.002) and treatment at a non-National Cancer Institute (NCI) affiliate was associated with worse DSS (HR: 2.71, 95% CI: 1.47-4.98;  = 0.001). In this Medicaid-insured cohort of children and AYAs with Hodgkin lymphoma, Black race/ethnicity remained associated with inferior OS in multivariable models adjusted for disease, demographic, and treatment data. Further work is needed to identify dimensions of health care access not mediated by insurance, as findings suggest additional factors are contributing to observed cancer disparities in vulnerable pediatric and AYA populations.
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http://dx.doi.org/10.1089/jayao.2021.0131DOI Listing
October 2021

Electrospun ZIF-derived cavity porous carbon nanofibers as a freestanding cathode for lithium-oxygen batteries with ultralow overpotential.

Nanoscale 2021 Oct 14;13(39):16477-16486. Epub 2021 Oct 14.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Construction of an efficient electrocatalyst for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) with low overpotential and cycling stability for lithium-oxygen batteries still remains a puzzling challenge. Herein, we propose a scalable approach to integrate ZIF derivatives into cavity porous carbon nanofibers (CPCNFs) an electrospinning technique and thermal treatment (Zn/[email protected]). The ultralong interconnected nanofiber matrix is beneficial, and the developed Zn/[email protected] catalyst with excellent flexibility can be utilized as a free-standing electrode based on an air-cathode. Moreover, this confinement strategy ensures the dispersion of Co-based species and abundant porosity structure, which contributes to the transport and adsorption of oxygen and exposes more Co-N coordination catalytic centers, as a result of a drastically ultralow voltage gap. Consequently, a cell based on a Zn/[email protected] electrode presents remarkably decreased charge-discharge polarization (0.36 V), a high initial discharge capacity with an ultra-low overpotential of 0.59 V, and long-term cyclability with a cut-off capacity of 0.2 mA h cm at 0.02 mA cm. We hope that our protocol will offer instruction for the design and application of oxygen electrocatalysts for energy conversion and storage.
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http://dx.doi.org/10.1039/d1nr04850cDOI Listing
October 2021

The complete mitochondrial genome of (Rössler, 1864) (Lepidoptera: Tortricidae).

Mitochondrial DNA B Resour 2021 22;6(10):2999-3000. Epub 2021 Sep 22.

College of Life Sciences, Dezhou University, Dezhou, Shandong, China.

The complete mitogenome of (Rössler, 1864) was sequenced and analyzed. The genome is 15,433 bp long with a high A + T content (80.6%), and consists of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and a noncoding control region. A phylogenetic analysis of 18 tortricid species for which mitogenes are available showed strong support for the monophyly of Tortricinae.
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http://dx.doi.org/10.1080/23802359.2021.1975514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462843PMC
September 2021

Influence of Cr (VI) concentration on Cr (VI) reduction and electricity production in microbial fuel cell.

Environ Sci Pollut Res Int 2021 Oct 17;28(38):54170-54176. Epub 2021 Aug 17.

Beijing Key Laboratory of Resource-oriented Treatment of Industrial pollutants, Beijing, 100083, China.

Microbial fuel cell is an efficient technology to reduce pollutants of the heavy metal ions. Herein, a dual-chamber microbial fuel cell (MFC) coupled with abio-cathode and electrochemically active bacteria is fabricated to treat Cr (VI) containing wastewater and harvest bioelectricity simultaneously. To investigate the wide application of MFC for various industries, four different concentrations of Cr (VI) (6 mg/L, 15 mg/L, 40 mg/L, 100 mg/L) are used to explore the removal efficiency of Cr (VI) and the corresponding power performance. We find that the power performance gradually increases with the increment of the initial Cr (VI) concentration. Significantly, a maximum power density of 35.3 mW/m can be achieved with the initial concentration of 100mg/L Cr (VI), while MFC only generate negligible power density (2.6 mW/m) without the presence of Cr (VI). Meanwhile, MFC combined with the initial Cr (VI) concentration of 15 mg/L shows the highest Cr (VI) removal of 66.5%. Moreover, partial precipitates are found on the cathode surface and X-ray photoelectron spectroscopy (XPS) analysis has demonstrated that the Cr (VI) is successfully reduced into Cr (III). This study offers an alternative technology to remove Cr (VI) and synchronous electricity generation.
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http://dx.doi.org/10.1007/s11356-021-15889-wDOI Listing
October 2021

1-Methylcyclopropene (1-MCP) retards the senescence of by regulating the cellular energy status and membrane lipid metabolism.

Food Sci Nutr 2021 Aug 23;9(8):4349-4363. Epub 2021 Jun 23.

College of Food Science Northeast Agricultural University Harbin PR China.

1-MCP is an ethylene inhibitor which can delay the ripening and senescence of fruits and vegetables effectively. (PA) is one of the wild vegetables which is famous and nutrient in China. However, the mechanism of PA preservation treated with 1-MCP has not been reported. Consequently, the effects of postharvest 1-MCP treatment on the changes in quality, energy metabolism, and membrane lipid metabolism of PA were investigated in this study. The results indicated that 1-MCP treatment could effectively inhibit the decreases in firmness, titratable acid (TA) content and the increases in weight loss rate, malondialdehyde (MDA) content, membrane permeability, and membrane lipid metabolism-related enzymes in PA. The cellular energy charge (EC) and the levels of ATP, ATP/ADP, and ATP/AMP, the activities of energy metabolism-related enzymes, NAD, and NADH were maintained, and the decreases in unsaturated fatty acids and the ratio of unsaturated-to-saturated fatty acids in the membrane of PA cells were effectively retarded by 1-MCP treatment. A positive correlation was observed between cellular ATP levels and the ratio of unsaturated-to-saturated fatty acids, while negative correlations were observed between the ratio of unsaturated-to-saturated fatty acids and both lipid peroxidation and membrane permeability. These results indicated that higher levels of energy status, unsaturated-to-saturated fatty acid ratios, and lipid metabolism in the membrane could preserve the membrane integrity of postharvest PA and effectively extend its shelf life.
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http://dx.doi.org/10.1002/fsn3.2406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358344PMC
August 2021

Efficiency of Noninvasive Prenatal Testing for Sex Chromosome Aneuploidies.

Gynecol Obstet Invest 2021 12;86(4):379-387. Epub 2021 Aug 12.

Medical Genetic Lab, Obstetrics and Gynecology Department, Tianjin Medical University General Hospital, Tianjin, China.

Objective: This study was designed to investigate the efficiency of noninvasive prenatal testing (NIPT) for screening fetal sex chromosome aneuploidies (SCAs) through sequencing of cell-free DNA in maternal plasma.

Methods: This is a retrospective study on the positive NIPT results for SCAs collected from our hospital between January 2012 and December 2018. Samples with positive NIPT results for SCAs were then confirmed by prenatal or postnatal karyotyping analysis.

Results: After cytogenetic analysis, abnormal karyotypes were confirmed in 104 cases and the overall positive predictive value (PPV) of NIPT for SCAs was 43.40% (102/235). The most frequently detected karyotypes included 47,XXY (n = 42), 47,XXX (n = 20), 47,XYY (n = 16), and 45,X (n = 2). Meanwhile, 10 cases were confirmed with mosaic karyotype 45,X/46,XX and 14 cases with numerical or structural chromosome abnormalities, including a double trisomy 48,XXX,+18. Cytogenetic results from the other 131 cases showed normal XX or XY, which were discordant with NIPT results. Upon analysis of parental karyotypes, 29 (12.34%) showed false positivity in NIPT results that were caused by maternal sex chromosome abnormalities.

Conclusion: NIPT is an effective screening tool for SCA with a PPV of 43.40%. Maternal karyotype abnormalities occurred in 12.34% of the cases with abnormal NIPT. Diagnostic testing of the fetus and the mother are recommended.
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http://dx.doi.org/10.1159/000518002DOI Listing
September 2021

UiO-66-NH Fabrics: Role of Trifluoroacetic Acid as a Modulator on MOF Uniform Coating on Electrospun Nanofibers and Efficient Decontamination of Chemical Warfare Agent Simulants.

ACS Appl Mater Interfaces 2021 Aug 11;13(33):39976-39984. Epub 2021 Aug 11.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Protective fabrics with air-permeable and flexible features are crucial for practical application in the detoxification of chemical warfare agents (CWAs). Zr-based metal-organic frameworks (Zr-MOFs) are desirable to exhibit outstanding degradation toward CWAs. However, generally, MOFs with powders cannot afford the utilization as a protective layer directly; meanwhile, it is still a puzzling challenge to integrate MOFs with textiles efficiently. Herein, we develop a scalable and controllable strategy to fabricate UiO-66-NH on electrospun polyacrylonitrile nanofibers (UiO-66-NH fabrics) firmly and uniformly to capture and catalyze 2-chloroethyl ethyl sulfide (CEES) effectively for self-detoxification. The obtained UiO-66-NH fabrics are greatly capable of specific surface area, ample porosity, excellent crystallinity, and abundant catalytic active sites. Consequently, CEES can be removed efficiently up to 97.7% after 48 h by reaction and adsorption. The degradation products mainly including ethyl-2-hydroxyethyl sulfide, ether, bis[2-(ethylthio)ethyl], and 2-(2-(ethylthio)ethylamino) terephthalic acid are detected. Moreover, the obtained nanofibrous fabrics possess air-permeable, washable, and flexible as well as lightweight merits, totally ensuring their promising engineering applications for protective clothing.
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http://dx.doi.org/10.1021/acsami.1c12751DOI Listing
August 2021

Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on HO-Induced HEK293 Cells: Regulation of Cellular Antioxidant Status.

Oxid Med Cell Longev 2021 9;2021:9996040. Epub 2021 Jul 9.

College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

Araloside A is a pentacyclic triterpenoid saponin, and L-ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L-ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L-ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and HO; and the production of intracellular reactive oxygen species (ROS), protein carbonyls, and 8-hydroxy-2-deoxy guanosine (8-OHdG). Free radical scavenging ability was positively correlated with superoxide dismutase (SOD) and catalase (CAT) activity, the glutathione (GSH)/oxidized glutathione (GSSG) ratio, and total antioxidant capacity (T-AOC). Our study is the first investigation of araloside A and L-ascorbic acid coadministration for the treatment of diseases caused by oxidative stress. The synergistic antioxidant effects of araloside A and L-ascorbic acid support their potential as functional food ingredients for the elimination of oxidative stress-induced adverse reactions.
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http://dx.doi.org/10.1155/2021/9996040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289608PMC
July 2021

A Silver Yarn-Incorporated Song Brocade Fabric with Enhanced Electromagnetic Shielding.

Materials (Basel) 2021 Jul 6;14(14). Epub 2021 Jul 6.

Department of Material Engineering, Faculty of Textile Engineering, Technical University of Liberec, 461 17 Liberec, Czech Republic.

The fabrics with electromagnetic interference (EMI) have been used in various fields. However, most studies related to the EMI fabrics focused on the improvement of the final electromagnetic shielding effectiveness (EM ) by adjusting the preparation parameters while the breathability of the EMI fabrics was affected and the visible surficial patterns on the EMI fabric was limited. In this work, the two samples based on the Song Brocade structure were fabricated with surficial visible pattern ''. One was fabricated with silver-plated polyamide (Ag-PA) yarns and the silk yarns, the another with polyester (PET) yarns and the silk yarns. The weaving structure of the two samples were investigated by scanning electronic microscopy (SEM) and laser optical microscopy (LOM). The resistance against the EM radiation near field communication (NFC) and the ultraviolet (UV) light was also evaluated. Besides, the surface resistance, the air permeability and the water evaporation rate were investigated. The results revealed that the '' appeared successfully on the surface of the two samples with stable weaving structure. The Ag-PA yarn-incorporated Song Brocade fabric had the EMI shielding effectiveness value around 50 dB, which was supported by the low surface resistance less than 40 Ω. The excellent NFC shielding of the Ag-PA yarn-incorporated Song Brocade was also found. The ultraviolet protection factor (UPF) value of the Ag-PA yarn-incorporated Song Brocade fabric was higher than 190. The air permeability and the evaporation rate of the Ag-PA yarn-incorporated Song Brocade fabric was higher than 99 mm/s, and 1.4 g/h, respectively. As a result, the Ag-PA yarn-incorporated Song Brocade fabrics were proposed for both the personal and the industrial scale utilization.
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http://dx.doi.org/10.3390/ma14143779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307523PMC
July 2021

Cold Plasma Preparation of Pd/Graphene Catalyst for Reduction of p-Nitrophenol.

Nanomaterials (Basel) 2021 May 20;11(5). Epub 2021 May 20.

College of Physical Science and Technology, Dalian University, Dalian 116622, China.

Supported metal nanoparticles with small size and high dispersion can improve the performance of heterogeneous catalysts. To prepare graphene-supported Pd catalysts, graphene and PdCl were used as support and Pd precursors, respectively. Pd/G-P and Pd/G-H catalysts were prepared by cold plasma and conventional thermal reduction, respectively, for the catalytic reduction of p-nitrophenol (4-NP). The reaction followed quasi-first-order kinetics, and the apparent rate constant of Pd/G-P and Pd/G-H was 0.0111 and 0.0042 s, respectively. The graphene support was exfoliated by thermal reduction and cold plasma, which benefits the 4-NP adsorption. Pd/G-P presented a higher performance because cold plasma promoted the migration of Pd species to the support outer surface. The Pd/C atomic ratio for Pd/G-P and Pd/G-H was 0.014 and 0.010, respectively. In addition, the Pd nanoparticles in Pd/G-P were smaller than those in Pd/G-H, which was beneficial for the catalytic reduction. The Pd/G-P sample presented abundant oxygen-containing functional groups, which anchored the metal nanoparticles and enhanced the metal-support interaction. This was further confirmed by the shift in the binding energy to a high value for Pd3d in Pd/G-P. The cold plasma method operated under atmospheric pressure is effective for the preparation of Pd/G catalysts with enhanced catalytic activity for 4-NP reduction.
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http://dx.doi.org/10.3390/nano11051341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160827PMC
May 2021

Capture or suppression? Attentional allocation upon reward and loss-associated nonsalient distractors are supported by distinct neural mechanisms: An EEG study.

Neuropsychologia 2021 07 3;157:107879. Epub 2021 May 3.

School of Psychology, Northeast Normal University, Changchun, China.

Previous studies suggest that a reward-associated salient distractor can induce bottom-up attentional capture. Hitherto, the neurophysiological mechanisms underlying attentional allocation upon reward/loss associated nonsalient stimulus remain hardly investigated. The present study built the association between nonsalient stimuli and value, and tested it with a decision-making task. Consequently, we examined whether and how reward/loss-associated nonsalient stimuli (as distractors) influenced attentional allocation in a rapid serial visual presentation task. Behavioral analysis showed a significantly faster recognition of target in the loss condition compared to performance in the neutral/reward conditions. Electrophysiological results showed that reward-associated distractors induced a significant Pd component, while loss-associated distractors induced a significantly higher theta oscillation. These results demonstrated that subjects could proactively suppress reward-associated distractors. More importantly, we showed that attentional allocation upon reward/loss-associated nonsalient distractors is supported by distinct neural mechanisms.
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http://dx.doi.org/10.1016/j.neuropsychologia.2021.107879DOI Listing
July 2021

Decorating metal organic framework on nickel foam for efficient Cu removal based on adsorption and electrochemistry.

Environ Technol 2021 May 8:1-9. Epub 2021 May 8.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing, People's Republic of China.

The removal of heavy metal ions in wastewater has a great significance to human health and environment protection. Metal organic framework possesses high surface area, rich porosity, tunable pore size and abundant active sites. However, the intrinsic aggregation and fragility of MOF nanoparticles make its poor adsorption and undesirable reusage. Herein, a facile and unique hot-pressing method is adopted to decorate the MOF nanoparticles on nickel foam (ZIF-8/NF), which simultaneously serves as self-supporting substrate of ZIF-8 nanoparticles and electrode of a self-powered multifunctional purification system. In adsorption, the ZIF-8/NF composite presents high Cu removal rate of 49.5% with the concentration of 10 mg/100 ml. More importantly, integrating with electrochemistry, the Cu removal rate of the ZIF-8/NF composite reaches 54.7% in 5 min. The superior performance is attributed to the comprehensive effects of ion exchange, chemical bonding and physical adsorption. Moreover, the low-cost, fast and scalable preparation contributes to commercially fabricate MOF nanoparticles on self-supported substrate to treat wastewater with high efficiency and good recyclability.
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http://dx.doi.org/10.1080/09593330.2021.1921043DOI Listing
May 2021

Association between preexisting mental illnesses and mortality among medicaid-insured women diagnosed with breast cancer.

Soc Sci Med 2021 02 23;270:113643. Epub 2020 Dec 23.

Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, One University Place, Rensselaer, NY, United States. Electronic address:

Background: We investigated the impact of preexisting mental illnesses on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer.

Methods: Data from the New York State Cancer Registry for 10,444 women diagnosed with breast cancer from 2004 to 2016 and aged <65 years at diagnosis were linked with Medicaid claims. Women were categorized as having depression or a severe mental illness (SMI) if they had at least three relevant diagnosis claims with at least one claim within three years prior to breast cancer diagnosis. SMI included schizophrenia, bipolar disorder, and other psychotic disorders. Estimated menopausal status was determined by age (premenopausal age <50; postmenopausal age ≥50). Hazard ratios (HR) and 95% confidence intervals (95%CI) were calculated with Cox proportional hazards regression, adjusting for potential confounders.

Results: Preexisting SMI was associated with greater all-cause (HR = 1.36; 95%CI 1.18, 1.57) and cancer-specific (HR = 1.21; 95%CI 1.03, 1.44) mortality compared to those with no mental illnesses. No association was observed between preexisting depression and mortality. Among racial/ethnic subgroups, the association between SMI and all-cause mortality was observed among non-Hispanic white (HR = 1.47; 95%CI 1.19, 1.83) and non-Hispanic Asian/Pacific Islander (HR = 2.59; 95% 1.15, 5.87) women. Additionally, mortality hazards were greatest among women with preexisting SMI that were postmenopausal (HR = 1.49; 95%CI 1.25, 1.78), obese (HR = 1.58; 95%CI 1.26, 1.98), and had documented tobacco use (HR = 1.42; 95%CI 1.13, 1.78).

Conclusion: Women with preexisting SMI prior to breast cancer diagnosis have an elevated mortality hazard and should be monitored and treated by a coordinated cross-functional clinical team.
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http://dx.doi.org/10.1016/j.socscimed.2020.113643DOI Listing
February 2021

L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis.

Front Immunol 2020 2;11:575173. Epub 2020 Oct 2.

College of Food Science, Northeast Agricultural University, Harbin, China.

Previous studies have suggested that the bacteria strain could be effective in ulcerative colitis (UC) management. However, its effects are strain-specific and the related mechanisms for its attenuating effects on UC remain unclear. This study aimed to elucidate the underlying mechanisms for the protective effect of on UC. Firstly, 15 strains were screened for potential probiotic characteristics with good tolerance to simulated human gastrointestinal transit and adhesion. Secondly, the inflammatory response of selected strains to the Caco-2 cells induced by lipopolysaccharide (LPS) was measured. Finally, an mouse model induced by dextran sulfate sodium (DSS) was used to assess the beneficial effects and likely action mechanisms the successfully screened strain, L15. results showed that L15 possessed the highest gastrointestinal transit tolerance, adhesion and reduction of pro-inflammatory abilities compared to the other screened strains. , high dose of L15 supplementation increased the body weight, colon length and anti-inflammatory cytokine production. Pro-inflammatory cytokine production, disease activity index (DAI) levels and myeloperoxidase (MPO) parameters decreased using this strain. In addition, L15 alleviated the histopathological changes in colon, modulated the gut microbiota, and decreased LPS secretion. The activities of this strain down-regulated the expression of TLR4 and MyD88 genes as well as genes associated with NF-κB signaling pathway. Our findings present L15 as a new probiotic, with promising application for UC management.
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http://dx.doi.org/10.3389/fimmu.2020.575173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566170PMC
June 2021

Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.

J Cell Sci 2020 12 9;133(23). Epub 2020 Dec 9.

Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430000, China

Endometrial receptivity plays a vital role in successful embryo implantation in pigs. MicroRNAs (miRNAs), known as regulators of gene expression, have been implicated in the regulation of embryo implantation. However, the role of miRNAs in endometrial receptivity during the pre-implantation period remains elusive. In this study, we report that the expression level of (ssc)-miR-21-5p in porcine endometrium tissues was significantly increased from day 9 to day 12 of pregnancy. Knockdown of ssc-miR-21-5p inhibited proliferation and migration of endometrial epithelial cells (EECs), and induced their apoptosis. We verified that programmed cell death 4 (PDCD4) was a target gene of ssc-miR-21-5p. Inhibition of PDCD4 rescued the effect of ssc-miR-21-5p repression on EECs. Our results also revealed that knockdown of ssc-miR-21-5p impeded the phosphorylation of AKT (herein referring to AKT1) by targeting PDCD4, which further upregulated the expression of Bax, and downregulated the levels of Bcl2 and Mmp9. Furthermore, loss of function of (mmu)-miR-21-5p resulted in a decreased number of implanted mouse embryos. Taken together, knockdown of ssc-miR-21-5p hampers endometrial receptivity by modulating the PDCD4/AKT pathway.
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http://dx.doi.org/10.1242/jcs.248898DOI Listing
December 2020

Nonlinear-Optical Crystal RbYBO with Condensed BO Blocks That Exhibits an Intriguing Structural Arrangement and a Short Ultraviolet Absorption Edge.

Inorg Chem 2020 Sep 4;59(18):13029-13033. Epub 2020 Sep 4.

Beijing Center for Crystal Research and Development, Key Laboratory of Functional Crystals and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Nonlinear-optical (NLO) crystals, which can regulate the laser wavelength through a cascading second-harmonic-generation technique, have been widely utilized in the field of optoelectronics. In this work, we grew the NLO borate crystal RbYBO (RYBO) using the spontaneous crystallization method. RYBO crystallizes in a chiral trigonal space group of 32 with a new type of structural arrangement built from Y-O short chains and BO groups. It is significantly different from the known structure of chemical analogues RbREBO (RE = Nd, Eu) not only in the halved unit cell parameter but also in the Y-O connection manner. The NLO response of RYBO is about 0.8KDP, 8-fold larger than that of KBO·4HO with the same BO groups because of the coexistence of two NLO-active units of the distorted YO octahedra and BO anions. Thanks to the short ultraviolet (UV) cutoff, RYBO may have potential NLO applications in the UV and even deep-UV spectral regions.
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http://dx.doi.org/10.1021/acs.inorgchem.0c02372DOI Listing
September 2020

and double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.

Elife 2020 09 2;9. Epub 2020 Sep 2.

State Key Laboratory of Animal Nutrition and Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.

Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for known receptor proteins CD163 and pAPN and show that DKO pigs are completely resistant to genotype 2 PRRSV and TGEV. We found no differences in meat-production or reproductive-performance traits between wild-type and DKO pigs, but detected increased iron in DKO muscle. Additional infection challenge experiments showed that DKO pigs exhibited decreased susceptibility to porcine deltacoronavirus (PDCoV), thus offering unprecedented in vivo evidence of pAPN as one of PDCoV receptors. Beyond showing that multiple gene edits can be combined in a livestock animal to achieve simultaneous resistance to two major viruses, our study introduces a valuable model for investigating infection mechanisms of porcine pathogenic viruses that exploit pAPN or CD163 for entry.
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http://dx.doi.org/10.7554/eLife.57132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467724PMC
September 2020

Pillar-Layered Metal-Organic Frameworks Based on a Hexaprismane [Co6(μ3-OH)6] Cluster: Structural Modulation and Catalytic Performance in Aerobic Oxidation Reaction.

Inorg Chem 2020 Aug 7;59(16):11728-11735. Epub 2020 Aug 7.

Beijing Key Laboratory for Green Catalysis and Separation, Beijing University of Technology, Beijing 100124, P. R. China.

Embedding a functional metal-oxo cluster within the matrix of metal-organic frameworks (MOFs) is a feasible approach for the development of advanced porous materials. Herein, three isoreticular pillar-layered MOFs (Co-MOF-1-3) based on a unique [Co(μ-OH)] cluster were designed, synthesized, and structurally characterized. For these Co-MOFs, tuning of the framework backbone was facilitated due to the existence of second ligands, which results in adjustable apertures (8.8 to 13.4 Å) and high Brunauer-Emmett-Teller surfaces (1896-2401 m g). As the [Co(μ-OH)] cluster has variable valences, these MOFs were then utilized as heterogeneous catalysts for the selective oxidation of styrene and benzyl alcohol, showing high conversion (>90%) and good selectivity. The selectivity of styrene to styrene oxide surpassed 80% and that of benzyl alcohol to benzaldehyde was up to 98%. The calculated TOF values show that the increase of reaction rate is positively correlated with the enlargement of pore sizes in these MOFs. Further, a stability test and cycling experiment proved that these Co-MOFs have well-observed stability and recyclability.
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http://dx.doi.org/10.1021/acs.inorgchem.0c01611DOI Listing
August 2020

Coordination-driven assembly of a 3d-4f heterometallic organic framework with 1D CuI and Eu-based chains: syntheses, structures and various properties.

Dalton Trans 2020 Aug;49(32):11209-11216

Key Laboratory of Sustainable Development of Polar Fisheries, Ministry of Agriculture and Rural affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences; Laboratory for Marine Drugs and Byproducts of Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266071, P. R. China.

A three-dimensional porous 3d-4f heterometallic organic framework, namely, {[Eu3(Cu4I4)3(INA)9(DMF)4]·3DMF}n (YNU-2), was successfully prepared under solvothermal conditions. There are two different one-dimensional metal chains in the structure, namely, Cu4I4 and EuIII-based chains, resulting in an excellent stability of the prepared sample. A N2 sorption isotherm at 77 K revealed that the activated sample exhibits a Brunauer-Emmett-Teller surface area of 371 m2 g-1, while, YNU-2 can adsorb obviously higher CO2 amounts than CH4 at 273 K and 298 K under 1 atm because of the stronger interaction force between CO2 and the porous skeleton. Furthermore, YNU-2 is highly efficient heterogeneous catalyst for chemical fixation of the CO2 and epoxides into cyclic carbonates with a preferable recyclability. Taking into account its excellent stability, the prepared sample can be used to construct an electrochemical adapter sensor for detecting cocaine with a detection limit of 0.27 pg mL-1 in the wide range of 0.001-0.5 ng mL-1.
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http://dx.doi.org/10.1039/d0dt01811bDOI Listing
August 2020

Metal-organic frameworks for the energy-related conversion of CO into cyclic carbonates.

Dalton Trans 2020 Aug 8;49(29):9935-9947. Epub 2020 Jul 8.

Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100, P. R. China.

Excessive emissions of carbon dioxide (CO) in the atmosphere result in a series of energy and environmental issues all around the word. Thus, it is urgent to prepare efficient materials for the conversion of CO as a C1 source into energy-related chemical products. Porous metal-organic frameworks (MOFs) are a class of rapidly growing crystalline materials, which have attracted significant attention for application in the conversion of CO into cyclic carbonates. In this review article, the developments made in recent years with respect to the application of MOFs as heterogeneous catalysts for the energy-related conversion of CO into cyclic carbonates are highlighted; moreover, we have further discussed the opportunities and challenges in the use of MOFs in this field.
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http://dx.doi.org/10.1039/d0dt01516dDOI Listing
August 2020

Heavy metal elimination based on metal organic framework highly loaded on flexible nanofibers.

Environ Res 2020 09 19;188:109742. Epub 2020 Jun 19.

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China; Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, Beijing 100083, China. Electronic address:

Efficient adsorbents for removal heavy metals are extensively urgent in modern society. Metal-organic frameworks (MOFs) with abundant porosity and tunable structure make it potential to access the advantages of high permeability and adsorbability in water pollutant control. However, MOFs nanoparticles inconvenient to recycle in solution hinder its application in water pollutant treatment. Herein, we report an in-situ growth and large-scalable manufacturing method to fabricate ZIF-8 nanoparticles on electrospun polyacrylonitrile (PAN) nanofibers membrane (ZIF-8/PAN NF) by hot pressing. Consequently, the prepared ZIF-8/PAN NF possesses high loading, uniform dispersion and large-scalable area as well as good flexibility. The fabricated ZIF-8/PAN NF exhibits excellent performance with fast flux (12,000 L/(mh)) and high filtration efficiency (96.5%) for Cu in dynamic adsorption. Additionally, adsorption and electrochemistry are introduced simultaneously. The Cu removal rate of ZIF-8/PAN NF reaches 34.1% in 4 min with combination of adsorption and electrochemistry. While it is 29.2% for Cu elimination in adsorption. Given the outstanding performance and easy manufacture, this study might bring MOFs powder to eliminate water pollution into practical application.
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http://dx.doi.org/10.1016/j.envres.2020.109742DOI Listing
September 2020

Assembly of Two Self-Interpenetrating Metal-Organic Frameworks Based on a Trigonal Ligand: Syntheses, Crystal Structures, and Properties.

Inorg Chem 2020 May 7;59(10):7135-7142. Epub 2020 May 7.

College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, People's Republic of China.

Two self-interpenetrating metal-organic frameworks (MOFs) and were designed and constructed through the coordination self-assembly of transition metal nodes and a trigonal ligand. They both exhibit interesting three-dimensional constructions with the 1 + 2 self-locked mode. Because of the outstanding moisture susceptibility and luminescence property, MOF has a potential detectability toward nitrofurantoin (NFT) in water. More importantly, MOF can efficiently monitor NFT in bovine serum. Taking into account of Lewis basic sites in the skeleton, MOF can be implemented as an outstanding heterogeneous catalyst for the Knoevenagel reaction. Furthermore, they both reveal excellent circularity and an application effect for five cycles.
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http://dx.doi.org/10.1021/acs.inorgchem.0c00596DOI Listing
May 2020

Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury.

Apoptosis 2020 06;25(5-6):341-353

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, People's Republic of China.

Soluble receptor for advanced glycation end-products (sRAGE), which exerts cardioprotective effect through inhibiting cardiomyocyte apoptosis and autophagy during ischemia/reperfusion (I/R) injury, is also known to enhance angiogenesis in post-ischemic reperfusion injury-critical limb ischemia (PIRI-CLI) mice. However, whether sRAGE protects the heart from myocardial I/R injury via promoting angiogenesis remains unclear. Myocardial model of I/R injury was conducted by left anterior descending (LAD) ligation for 30 min and reperfusion for 2 weeks in C57BL/6 mice. And I/R injury in cardiac microvascular endothelial cells (CMECs) was duplicated by oxygen and glucose deprivation. The results showed that I/R-induced cardiac dysfunction, inflammation and myocardial fibrosis were all reversed by sRAGE. CD31 immunohistochemistry staining showed that sRAGE increased the density of vessels after I/R injury. The results from cultured CMECs showed that sRAGE inhibited apoptosis and increased proliferation, migration, angiogenesis after exposure to I/R. These effects were dependent on signal transducer and activator of transcription 3 (STAT3) pathway. Together, the present study demonstrated that activation of STAT3 contributed to the protective effects of sRAGE on myocardial I/R injury via promoting angiogenesis.
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http://dx.doi.org/10.1007/s10495-020-01602-8DOI Listing
June 2020

Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer.

Cancer Epidemiol 2020 06 1;66:101710. Epub 2020 Apr 1.

Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY, United States; Bureau of Cancer Epidemiology, New York State Department of Health, 150 Broadway, Suite 361, Albany, NY, United States.

Background: We investigated the influence preexisting type 2 diabetes mellitus (T2DM) and antidiabetic drugs have on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer.

Methods: 9221 women aged <64 years diagnosed with breast cancer and reported to the New York State (NYS) Cancer Registry from 2004 to 2016 were linked with Medicaid claims. Preexisting T2DM was determined by three diagnosis claims for T2DM with at least one claim prior to breast cancer diagnosis and a prescription claim for an antidiabetic drug within three months following breast cancer diagnosis. Estimated menopausal status was determined by age (premenopausal age <50; postmenopausal age ≥50). Hazard ratios (HR) and 95 % confidence intervals (95 %CI) were calculated with Cox proportional hazards regression, adjusting for confounders.

Results: Women with preexisting T2DM had greater all-cause (HR = 1.40; 95 %CI 1.21, 1.63), cancer-specific (HR = 1.24; 95 %CI 1.04, 1.47), and cardiovascular-specific (HR = 2.46; 95 %CI 1.54, 3.90) mortality hazard compared to nondiabetic women. In subgroup analyses, the association between T2DM and all-cause mortality was found among non-Hispanic White (HR 1.78 95 %CI 1.38, 2.30) and postmenopausal (HR = 1.47; 95 %CI 1.23, 1.77) women, but not among other race/ethnicity groups or premenopausal women. Additionally, compared to women prescribed metformin, all-cause mortality hazard was elevated among women prescribed sulfonylurea (HR = 1.44; 95 %CI 1.06, 1.94) or insulin (HR = 1.54; 95 %CI 1.12, 2.11).

Conclusion: Among Medicaid-insured women with breast cancer, those with preexisting T2DM have an increased mortality hazard, especially when prescribed sulfonylurea or insulin. Further research is warranted to determine the role antidiabetic drugs have on survival among women with breast cancer.
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http://dx.doi.org/10.1016/j.canep.2020.101710DOI Listing
June 2020

Rational design and synthesis of a stable pillar-layer Na-organic framework as a multi-responsive luminescent sensor in aqueous solutions.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Apr 23;230:118106. Epub 2020 Jan 23.

College of Chemistry and Chemical Engineering, Dezhou University, Dezhou 253023, China.

A stable pillar-layer Na-organic framework, [Na(DCPB)∙(HO)] (namely 1), was rationally designed and synthesized by the assemble process of Na and 1,3-di(4'-carboxyl-phenyl)benzene (HDCPB). Benefiting from the luminescent property and high stability in water, the as-synthesized 1 is a potential multi-responsive luminescent sensor material toward CrO, Fe, and nitrofurazone (NFZ) in water. Ground 1 not only has the excellent detectability and selectivity but also possesses outstanding stability and circularity. The calculated K values of 1 are 8.8×10 for Fe, 9.9×10 for CrO, and 2.7×10 M for NFZ in aqueous solutions, respectively. Furthermore, 1 is able to accurately detect NFZ in real bovine serum samples through luminescence detection technology.
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http://dx.doi.org/10.1016/j.saa.2020.118106DOI Listing
April 2020

Combining unsaturated metal sites and narrow pores within a Co(ii)-based MOF towards CO separation and transformation.

Dalton Trans 2020 Feb 29;49(7):2058-2062. Epub 2020 Jan 29.

College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266000, P. R. China.

A Co(ii)-based MOF, {[Co(L)(bpb)(DMA)(HO)]·Solvents} (RH-1), with a unique interpenetrated framework has been solvothermally prepared. Because of its unsaturated metal sites and narrow pores inside the framework, RH-1 demonstrated excellent selective CO adsorption over N and CH and good performance in catalytic CO conversion to cyclic carbonates under mild conditions.
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http://dx.doi.org/10.1039/c9dt04736kDOI Listing
February 2020

Woven Wearable Electronic Textiles as Self-Powered Intelligent Tribo-Sensors for Activity Monitoring.

Glob Chall 2019 Dec 14;3(12):1900070. Epub 2019 Nov 14.

School of Energy and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China.

Wearable and shape-adaptive electronic textiles (E-textiles) for human activities detection such as diversity joints motion are highly desired. However, conventional E-textiles still remain great challenges, such as flexibility, air permeability, and large-area fabrication. Here, a fabric E-textile is developed as a self-powered textile for tracking active motion signals. The fiber-shaped coaxial tribo-sensor is fabricated with silver yarn (Ag) and polytetrafluoroethylene yarn, which allows for integrating well with cloths at large scales due to its satisfactory breathability, good washability, and desirable flexibility. Based on the coaxial-structured design, the fabricated E-textile is optimized to generate the output performance with maximum short-current ( ) of 90 nA and open-voltage ( ) of 8 V. Moreover, the E-textile can also be utilized as a self-powered activity tribo-sensor to monitor the motion signals of the human body. More significantly, the obtained E-textile performs outstanding finger-touching sensitivity, which can be applied in a wireless controller, active sensor, and human-machine interactions. This work presents a new way for a multifunctional E-textile with potential applications in smart home systems, wearable electronics, and personalized healthcare.
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http://dx.doi.org/10.1002/gch2.201900070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888749PMC
December 2019

Preparation of Pd/C by Atmospheric-Pressure Ethanol Cold Plasma and Its Preparation Mechanism.

Nanomaterials (Basel) 2019 Oct 10;9(10). Epub 2019 Oct 10.

College of Physical Science and Technology, Dalian University, Dalian 116622, China.

Treatment with atmospheric-pressure (AP) hydrogen cold plasma is an effective method for preparing highly active supported metal catalytic materials. However, this technique typically uses H as working gas, which is explosive and difficult to transport. This study proposes the use of PdCl as a Pd precursor and activated carbon as the support to fabricate Pd/C catalytic materials (Pd/C-EP-Ar) by using ethanol-which is renewable, easily stored, and safe-combined with AP cold plasma (AP ethanol cold plasma) followed by calcination in Ar gas at 550 °C for 2 h. Both Pd/C-EP and Pd/C-HP fabricated using AP ethanol and hydrogen cold plasma (without calcination in Ar gas) respectively, exhibit low CO oxidation reactivity. The activity of Pd/C-EP is lower than Pd/C-HP, which is mainly ascribed to the carbon layer formed by ethanol decomposition during plasma treatment. However, the 100% CO conversion temperature () of Pd/C-EP-Ar is 140 °C, which is similar to that of Pd/C-HP-Ar fabricated using AP hydrogen cold plasma (calcined in Ar gas at 550 °C for 2 h). The characterization results of X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy indicated that the carbon layer formed by ethanol decomposition enhanced the interaction of metal nanoparticles to the support, and a high Pd/C atomic ratio was obtained. This was beneficial to the high CO oxidation performance. This work provides a safe method for synthesizing high-performance Pd/C catalytic materials avoiding the use of H, which is explosive and difficult to transport.
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http://dx.doi.org/10.3390/nano9101437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836268PMC
October 2019

A Facile Method for Preparing UiO-66 Encapsulated Ru Catalyst and its Application in Plasma-Assisted CO Methanation.

Nanomaterials (Basel) 2019 Oct 10;9(10). Epub 2019 Oct 10.

College of Physical Science and Technology, Dalian University, Dalian 116622, China.

With increasing applications of metal-organic frameworks (MOFs) in the field of gas separation and catalysis, the preparation and performance research of encapsulating metal nanoparticles (NPs) into MOFs ([email protected]) have attracted extensive attention recently. Herein, an [email protected] catalyst is prepared by a one-step method. Ru NPs are encapsulated in situ in the UiO-66 skeleton structure during the synthesis of UiO-66 metal-organic framework via a solvothermal method, and its catalytic activity for CO methanation with the synergy of cold plasma is studied. The crystallinity and structural integrity of UiO-66 is maintained after encapsulating Ru NPs according to the X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). As illustrated by X-ray photoelectron spectroscopy (XPS), high resolution transmission electron microscopy (HRTEM), and mapping analysis, the Ru species of the hydration ruthenium trichloride precursor are reduced to metallic Ru NPs without additional reducing processes during the synthesis of [email protected], and the Ru NPs are uniformly distributed inside the [email protected] Thermogravimetric analysis (TGA) and N sorption analysis show that the specific surface area and thermal stability of [email protected] decrease slightly compared with that of UiO-66 and was ascribed to the encapsulation of Ru NPs in the UiO-66 skeleton. The results of plasma-assisted catalytic CO methanation indicate that [email protected] exhibits excellent catalytic activity. CO conversion and CH selectivity over [email protected] reached 72.2% and 95.4% under 13.0 W of discharge power and a 30 mL·min gas flow rate ( V H 2 : V C O 2 = 4 : 1 ), respectively. Both values are significantly higher than pure UiO-66 with plasma and Ru/AlO with plasma. The enhanced performance of [email protected] is attributed to its unique framework structure and excellent dispersion of Ru NPs.
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http://dx.doi.org/10.3390/nano9101432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835285PMC
October 2019

Simultaneous optimization of the acidified water extraction for total anthocyanin content, total phenolic content, and antioxidant activity of blue honeysuckle berries ( L.) using response surface methodology.

Food Sci Nutr 2019 Sep 10;7(9):2968-2976. Epub 2019 Aug 10.

Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Harbin China.

The purpose of this study was to optimize the total anthocyanin content (TAC), total phenolic content (TPC), and antioxidant activity of acidified water extract from blue honeysuckle berries by response surface methodology (RSM). The optimized conditions were HCl concentration of 0.35%, liquid-solid ratio of 49.42 ml/g, and extraction temperature of 41.56°C for total anthocyanin content (24.01 ± 0.37 mg/g), total phenolic content (207.03 ± 3.31 mg/g), DPPH radical scavenging activity (68.24 ± 1.13%), and ABTS radical scavenging activity (70.05 ± 0.84%). The experimental results are consistent with the predicted values. The results showed that acidified water extraction was an effective, simple, and green technique for the extraction of total anthocyanins, total phenol, and antioxidant activity from blue honeysuckle berries.
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http://dx.doi.org/10.1002/fsn3.1152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766558PMC
September 2019
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