Publications by authors named "Xiu-Jie Zhang"

13 Publications

  • Page 1 of 1

Development and Evaluation of the Psychosocial Adaptation Questionnaire among Patients with Chronic Skin Disease.

Dermatology 2021 Mar 2:1-8. Epub 2021 Mar 2.

Department of Dermatology, The First Affiliated Hospital of China Medical University, Shenyang, China,

Background/objective: Chronic skin disease (CSD) often has physiological, psychological, and social impacts, which requires the patient to adjust to achieve psychosocial adaptation (PSA). As a standardized assessment instrument was lacking, we developed a PSA questionnaire for patients with CSD (PSAQ-CSD).

Methods: According to the steps of questionnaire development, a systematic process of scoping review, qualitative research, content validity expert review, testing in a sample of 321 adults, item analysis, and classical test theory methods were applied.

Results: Following item analysis and exploratory factor analyses, 18 items were eventually entered into the model of confirmatory factor analyses, with a cumulative contribution of 65.435%. Three subscales were developed: emotional, self-cognitive, and social dimensions. Item analysis, exploratory factor analyses, and content validity expert review narrowed the subscales to 8, 6, and 4 items, respectively.

Conclusions: The 18-item PSAQ-CSD has been confirmed to have good internal consistency reliability and convergent and discriminant validity. It may be a useful tool to evaluate the PSA among patients with CSD and provide a basis for further research.
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http://dx.doi.org/10.1159/000514306DOI Listing
March 2021

Exploring psychosocial adaptation among people with chronic skin disease: A grounded theory study.

Nurs Open 2021 Feb 25. Epub 2021 Feb 25.

Department of Nursing, The First Affiliated Hospital of China Medical University, Shenyang, China.

Aim: Chronic skin disease (CSD) often has devastating effects on the physiological, psychological and social aspects of patients, who must adapt to them. However, it is not clear how patients adapt, especially with regard to their psychosocial adaptation (PSA). This research explored a theoretical model of PSA among people with CSD.

Design: Following constructivist grounded theory methodology, a qualitative study was undertaken between August 2018 and June 2019.

Methods: Observation and semi-structured interview were conducted with included participants (n=19). Data were iteratively coded and analyzed by constant comparison following the key stages of initial, focused, axial and theoretical coding until saturation was achieved.

Results: When individuals face the impacts of disease, they try to adjust to adapt it. The findings showed the core category (self-cognitive) and the contributing categories (impacts of chronic skin disease, contextual factors, physiological experiences, psychological experiences, social experiences, and positive and negative psychosocial adaptations) of the PSA among people with CSD. The process of PSA among people with CSD was not linear throughout the disease and was instead entwined within a set of complexes (contextual factors-experience) interactions. The consequences of PSA included positive and negative aspects. The theoretical model of PSA among people with CSD will provide us with information needed to develop accurate assessment and effective intervention strategies. Understanding that PSA among people with CSD is a complex, dynamic, and interactional process may provide evidence for further assessing and meeting the needs of people.
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http://dx.doi.org/10.1002/nop2.823DOI Listing
February 2021

COVID-19: What is next for nursing in public health emergency?

Nurse Educ Pract 2020 07 12;46:102821. Epub 2020 Jun 12.

Department of Nursing, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.

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http://dx.doi.org/10.1016/j.nepr.2020.102821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291995PMC
July 2020

Interventions to reduce burnout of physicians and nurses: An overview of systematic reviews and meta-analyses.

Medicine (Baltimore) 2020 Jun;99(26):e20992

Department of Nursing, The First affiliated Hospital of Dalian Medical University, Dalian, China.

Objective: Numerous systematic reviews and meta-analyses on the interventions to reduce burnout of physicians and nurses have been published nowadays. This study aimed to summarize the evidence and clarify a bundled strategy to reduce burnout of physicians and nurses.

Methods: Researches have been conducted within Cochrane Library, PubMed, Ovid, Scopus, EBSCO, and CINAHL published from inception to 2019. In addition, a manual search for relevant articles was also conducted using Google Scholar and ancestral searches through the reference lists from articles included in the final review. Two reviewers independently selected and assessed, and any disagreements were resolved through a larger team discussion. A data extraction spreadsheet was developed and initially piloted in 3 randomly selected studies. Data from each study were extracted independently using a pre-standardized data abstraction form. The the Risk of Bias in Systematic reviews and assessment of multiple systematic reviews (AMSTAR) 2 tool were used to evaluate risk of bias and quality of included articles.

Results: A total of 22 studies published from 2014 to 2019 were eligible for analysis. Previous studies have examined burnout among physicians (n = 9), nurses (n = 6) and healthcare providers (n = 7). The MBI was used by majority of studies to assess burnout. The included studies evaluated a wide range of interventions, individual-focused (emotion regulation, self-care workshop, yoga, massage, mindfulness, meditation, stress management skills and communication skills training), structural or organizational (workload or schedule-rotation, stress management training program, group face-to-face delivery, teamwork/transitions, Balint training, debriefing sessions and a focus group) and combine interventions (snoezelen, stress management and resiliency training, stress management workshop and improving interaction with colleagues through personal training). Based on the Risk of Bias in Systematic reviews and AMSTAR 2 criteria, the risk of bias and methodological quality included studies was from moderate to high.

Conclusions: Burnout is a complicated problem and should be dealt with by using bundled strategy. The existing overview clarified evidence to reduce burnout of physicians and nurses, which provided a basis for health policy makers or clinical managers to design simple and feasible strategies to reduce the burnout of physicians and nurses, and to ensure clinical safety.
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http://dx.doi.org/10.1097/MD.0000000000020992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328917PMC
June 2020

Adherence status to Adjuvant Endocrine Therapy in Chinese Women with Early Breast Cancer and its influencing factors: A cross-sectional survey.

Cancer Med 2020 06 1;9(11):3703-3713. Epub 2020 Apr 1.

The First Affiliated Hospital of China Medical University, Shenyang, China.

Objective: Despite the proven benefits of adjuvant endocrine therapy, adherence to oral endocrine therapy in breast cancer treatment is a substantial problem. The aim of this study was to assess adherence to adjuvant endocrine therapy by women in China for the first 5 years, and to identify its influencing factors.

Methods: Stratified sampling method was adopted to select 1875 cases of breast cancer patients for cross-sectional telephone follow-up. Compliance to medications was assessed using the Morisky Medication Adherence Scale. Status of endocrine therapy was assessed using nine additional questions. Binomial regression was used when assessing the factors associated with persistence, multinomial regression models were used to assess factors associated with compliance.

Results: Of 888 patients who started adjuvant endocrine therapy, 769(86.6%) persisted and 119 (13.4%) discontinued. 760 patients who completed Morisky Medication Adherence Scale, the compliance was 7.4% low, 42% medium, and 50.6% high. The type of medication, duration of medication and side effects had an impact both on persistence and compliance. Age, history of radiotherapy and caregivers only had an impact on persistence.

Conclusions: Medication adherence was affected by many factors. Special attention and interventions should be given to women taking tamoxifen in the 2nd to 3rd year of medication, and aromatase inhibitors in the 1st to 2nd year. Further prospective design studies are needed to explore effective measures to improve medication adherence of women with breast cancer treated by endocrine therapy.
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http://dx.doi.org/10.1002/cam4.3017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286448PMC
June 2020

The psychosocial adaptation of patients with skin disease: a scoping review.

BMC Public Health 2019 Oct 29;19(1):1404. Epub 2019 Oct 29.

Department of Nursing, The First affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

Background: Skin disease is a global public health problem that often has physiological, psychological and social impacts. However, it is not very clear how to adapt to these impacts, especially psychosocial adaptation of patients with skin disease.

Methods: We searched EMBASE, PubMed, CINAHL and PsycINFO from 2009 to 2018. The following themes were extracted from the included articles: the concepts, related factors, and interventions for psychosocial adaptation of patients with skin disease. Two reviewers independently screened and analyzed.

Results: From 2261 initial records, 69 studies were identified and analyzed. The concept of psychosocial adaptation in patients with skin disease was referred to under an assortment of descriptions. The related factors for psychosocial adaptation in patients with skin disease included the following: demographic factors (sex, age, education level, ethnicity, BMI, sleep quality, marital status, exercise amount, family history, the use of topical treatment only, personality and history of smoking); disease-related factors (disease severity, clinical symptoms, localization and duration); psychological factors (anxiety/depression, self-esteem, body image, stigma and suicidal ideation); and social factors (social support, social interaction, sexual life, economic burden and social acceptance). Despite being limited in quantity, several studies have clarified the benefits of adjuvant care in the form of cognitive behavioral training, educational training and self-help programs, all of which have become common methods for dealing with the psychosocial impacts.

Conclusions: Based on the previous literatures, we constructed a protocol of care model for psychosocial adaptation in patients with skin disease. It not only provided the direction for developing new instruments that could assess psychosocial adaptation statue, but also a basis for helping patients adjust to changes in skin disease.
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http://dx.doi.org/10.1186/s12889-019-7775-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819547PMC
October 2019

Factors influencing medication-taking behaviour with adjuvant endocrine therapy in women with breast cancer: A qualitative systematic review.

J Adv Nurs 2020 Feb 13;76(2):445-458. Epub 2019 Nov 13.

Department of Nursing, The First Affiliated Hospital of China Medical University, Shenyang, China.

Aims: To explore the experience and feelings associated with the endocrine therapy treatment trajectory in women with breast cancer and what affects medication taking behaviour.

Design: Qualitative systematic review.

Data Sources: Qualitative studies were extracted from PubMed, EMBASE, CINAHL, PsycINFO from inception of each database until February 2019.

Review Methods: The systematic search method SPIDER (sample, phenomenon of interest, design, evaluation, research type) was used. Thematic synthesis of the qualitative data was used.

Results: A total of 478 were identified in the initial search. Only 17 articles met inclusion criteria and were included in this review. Five analytical themes and 17 descriptive subthemes were identified.

Conclusions: The systematic review highlights knowledge, balancing the scales, self-efficacy and support influence medication taking behaviour to women with breast cancer.

Impact: The medication taking behaviour of breast cancer women can be classified into four types: acceptance/persistence, bearing/suffering, hesitation/adjustment, refusing/abandoning. The four types can switch from one to another. Medication taking behaviour is affected by knowledge, balancing the scales, self-efficacy, and support. The medical institutions, communities, and families can gain knowledge of the treatment experiences of women to better understand medication taking behaviour and those at risk for non-adherence. Women wanted different types and amounts of information. Healthcare providers should be aware of patient preferences and take targeted interventions to help them receive treatment.
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http://dx.doi.org/10.1111/jan.14253DOI Listing
February 2020

TargetScore used to reveal potential targets of miRNA203 and miRNA-146a in psoriasis by integrating microRNA overexpression and microarray data.

Medicine (Baltimore) 2018 Oct;97(41):e12671

Department of Cardiology, The Fourth People's Hospital of Jinan, Ji-Nan, Shandong Province, China.

Objective: Systematic tracking of microRNA (miRNA) targets remains a challenge. In our work, we aimed to use TargetScore to investigate the potential targets of miRNA203 and miRNA-146a in psoriasis by integrating miRNA overexpression information and sequence data, and to further uncover the functions of miRNA203 and miRNA-146a in psoriasis.

Methods: This was a case-control bioinformatics analysis using already published microarray data of psoriasis. We calculated targetScores by combining log fold-change and sequence scores obtained from TargetScan context score, probabilities of conserved targeting, and derived the distribution of targetScores. The scoring cutoff was chosen based on the different targetScore distributions for the nonvalidated and validated targets. The potential target genes for miRNA-203 and miRNA-146a were predicted based on the targetScore threshold. To reveal the functions of miRNA-203 and miRNA-146a, we implemented pathway enrichment analyses for the targets of miRNA-203 and miRNA-146a.

Results: TargetScore >0.4 was selected as the threshold to filter out less confidence targets because we observed little overlap between the 2 distribution at targetScore = 0.4. Based on the targetScore >0.4, 49 target genes for miRNA-203 and 17 targets for miRNA-146a were identified. Pathway enrichment results showed that the target genes of miRNA-203 (including KIR2DL1, HLA-DQA1, KIR3DL1) only participated in antigen processing and presentation. The target genes of miRNA-146a (covering ADORA3, CYSLTR2, HRH4) were only involved in neuroactive ligand-receptor interaction.

Conclusion: MiRNA203 and miRNA-146a played important roles in psoriasis progression, partially through regulating the pathways of antigen processing and presentation, and neuroactive ligand-receptor interaction, respectively.
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http://dx.doi.org/10.1097/MD.0000000000012671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203501PMC
October 2018

Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide.

Org Lett 2017 06 22;19(11):2969-2972. Epub 2017 May 22.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. China.

An efficient Ni-catalyzed reductive carboxylation of allylic alcohols with CO has been successfully developed, providing linear β,γ-unsaturated carboxylic acids as the sole regioisomer with generally high E/Z stereoselectivity. In addition, the carboxylic acids can be generated from propargylic alcohols via hydrogenation to give allylic alcohol intermediates, followed by carboxylation. A preliminary mechanistic investigation suggests that the hydrogenation step is made possible by a Ni hydride intermediate produced by a hydrogen atom transfer from water.
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http://dx.doi.org/10.1021/acs.orglett.7b01208DOI Listing
June 2017

Palladium-Catalyzed C(sp)-H Oxygenation via Electrochemical Oxidation.

J Am Chem Soc 2017 03 17;139(8):3293-3298. Epub 2017 Feb 17.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.

Palladium-catalyzed C-H activation/C-O bond-forming reactions have emerged as attractive tools for organic synthesis. Typically, these reactions require strong chemical oxidants, which convert organopalladium(II) intermediates into the Pd or Pd oxidation state to promote otherwise challenging C-O reductive elimination. However, previously reported oxidants possess significant disadvantages, including poor atom economy, high cost, and the formation of undesired byproducts. To overcome these issues, we report an electrochemical strategy that takes advantage of anodic oxidation of Pd to induce selective C-O reductive elimination with a variety of oxyanion coupling partners.
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http://dx.doi.org/10.1021/jacs.7b01232DOI Listing
March 2017

Mitochondrial Genome Variation after Hybridization and Differences in the First and Second Generation Hybrids of Bream Fishes.

PLoS One 2016 8;11(7):e0158915. Epub 2016 Jul 8.

College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, Hubei, People's Republic of China.

Hybridization plays an important role in fish breeding. Bream fishes contribute a lot to aquaculture in China due to their economically valuable characteristics and the present study included five bream species, Megalobrama amblycephala, Megalobrama skolkovii, Megalobrama pellegrini, Megalobrama terminalis and Parabramis pekinensis. As maternal inheritance of mitochondrial genome (mitogenome) involves species specific regulation, we aimed to investigate in which way the inheritance of mitogenome is affected by hybridization in these fish species. With complete mitogenomes of 7 hybrid groups of bream species being firstly reported in the present study, a comparative analysis of 17 mitogenomes was conducted, including representatives of these 5 bream species, 6 first generation hybrids and 6 second generation hybrids. The results showed that these 17 mitogenomes shared the same gene arrangement, and had similar gene size and base composition. According to the phylogenetic analyses, all mitogenomes of the hybrids were consistent with a maternal inheritance. However, a certain number of variable sites were detected in all F1 hybrid groups compared to their female parents, especially in the group of M. terminalis (♀) × M. amblycephala (♂) (MT×MA), with a total of 86 variable sites between MT×MA and its female parent. Among the mitogenomes genes, the protein-coding gene nd5 displayed the highest variability. The number of variation sites was found to be related to phylogenetic relationship of the parents: the closer they are, the lower amount of variation sites their hybrids have. The second generation hybrids showed less mitogenome variation than that of first generation hybrids. The non-synonymous and synonymous substitution rates (dN/dS) were calculated between all the hybrids with their own female parents and the results indicated that most PCGs were under negative selection.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158915PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938612PMC
July 2017

The impact of psychosocial adaptation status on quality of life for Chinese patients with visual impairments.

J Clin Nurs 2014 Jan 10;23(1-2):75-81. Epub 2012 Dec 10.

Department of Nursing, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province; Department of Nursing, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province.

Aims And Objctives: To analyse the association of psychosocial adaptation with quality of life and to examine the influential factors for Chinese people with visual impairments.

Background: The status of psychosocial adaptation is the main influential factor for quality of life. The correlation between psychosocial adaptation and quality of life for various diseases has been studied previously. However, there have been few reports on the impact of psychosocial adaptation on quality of life in people with visual impairments.

Design: Survey.

Methods: In this study, subjects with visual impairment (n = 213) were interviewed to assess their demographics, disease-related information, psychosocial adaptation status and quality of life. The psychosocial adaptation questionnaire and quality of life scale for visually impaired patients were used to survey psychosocial adaptation and quality of life. Correlation and multiple stepwise regression analyses were used to study the association of psychosocial adaptation with quality of life in visually impaired patients.

Results: Psychosocial adaptation was significantly associated with quality of life, including the sense of belonging and psychological dimensions. The results also showed that there was statistical significance for the impact of occupational status, payment, monthly income (family), vision classification and psychosocial adaptation on quality of life, and the status of psychosocial adaptation was the main factor affecting the quality of life in people with visual impairments.

Conclusion: It was found that the status of psychosocial adaptation was conspicuously associated with multiple dimensions of quality of life. Therefore, psychosocial adaptation status should be given close attention in clinical care.

Relevance To Clinical Practice: Our results could be used to guide nurses in making a plan for health education and nursing that improves the quality of life for the visually impaired.
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http://dx.doi.org/10.1111/jocn.12041DOI Listing
January 2014

Development of a psychosocial adaptation questionnaire for Chinese patients with visual impairments.

J Clin Nurs 2011 Oct;20(19-20):2822-9

Department of Nursing, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

Aim: To develop a psychosocial adaptation questionnaire for Chinese patients with visual impairments and to examine its reliability and validity.

Background: Psychosocial adaptation with disease has been studied, however, there have been few reports on the impact of visual impairment on psychosocial adaptation. An instrument has not been developed to assess psychosocial adaptation with visual impairment specifically for patients in China.

Methods: Both qualitative and quantitative research methods were used. A questionnaire was developed based on the concept of psychosocial adaptation with visual impairment. Items for the questionnaire were developed by reviewing the literature and carrying out a semi-structured interview with 12 visually impaired patients. Five ophthalmologists and ten patients evaluated the content validity and face validity of the questionnaire, respectively. The method of convenient sampling was used to select 213 visually impaired patients in the Ophthalmology Department of the First Affiliated Hospital of China Medical University to participate in the study. Discriminative index and item-total correlation analyses were used to delete items that were lower than a set criterion. Regarding construct validity, factor analysis was performed. The Self-rating Anxiety Scale (SAS), General Self-Efficacy Scale (GSES) and Self Acceptance Questionnaire (SAQ) were used to evaluate criterion validity. Cronbach's alpha coefficient was used as an index of internal consistency. To evaluate test-retest reliability, 50 patients were re-evaluated after 24 hours.

Results: A total of 204 questionnaire items were created. 22 items were deleted by discriminative index and item-total correlation before factor analysis; 38 items were entered into the model for factor analysis. Seven factors were extracted by using principal factor analysis and varimax rotation, with a cumulative contribution of 59·18%. The correlation coefficients between the psychosocial adaptation questionnaire for visual impairment and the SAS, GSES and SAQ were -0·771, 0·754 and 0·722, respectively (p < 0·01). The Cronbach's alpha coefficient for the psychosocial adaptation questionnaire was 0·948. The alpha coefficients of seven sub-questionnaires ranged from 0·56-0·89. The correlation coefficients for the total questionnaire and seven sub-questionnaires ranged from 0·97-0·99 (p < 0·01).

Conclusion: The results of this study confirmed the reliability and validity of the 38-item psychosocial adaptation questionnaire for the visually impaired in China. It therefore can be used as a measurement tool for widespread, cost-effective clinical assessment and further research.

Relevance To Clinical Practice: The new tool may help nurses and other clinical personnel to evaluate the psychosocial adaptation of visually impaired patients and provide a suitable basis for assisting with adaptation to visual impairment and enhancing quality of life.
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http://dx.doi.org/10.1111/j.1365-2702.2011.03813.xDOI Listing
October 2011