Xinzhong Dong

Xinzhong Dong

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Xinzhong Dong

Publications by authors named "Xinzhong Dong"

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House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.

Nat Immunol 2019 Oct 7. Epub 2019 Oct 7.

Unité de Différenciation Epithéliale et Autoimmunité Rhumatoïde, UMR 1056, INSERM, Université de Toulouse, Toulouse, France.

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http://dx.doi.org/10.1038/s41590-019-0493-zDOI Listing
October 2019

A Pungent and Painful Toxin.

Cell 2019 Sep 29;178(6):1279-1281. Epub 2019 Aug 29.

The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.016DOI Listing
September 2019

Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms.

Sci Signal 2019 Sep 3;12(597). Epub 2019 Sep 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.aax3332DOI Listing
September 2019

Spicy Immunity: Pain to Gain.

Immunity 2019 Sep;51(3):426-428

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.08.014DOI Listing
September 2019

Calcium imaging approaches in investigation of pain mechanism in the spinal cord.

Exp Neurol 2019 Jul 7;317:129-132. Epub 2019 Mar 7.

The Solomon H. Snyder Department of Neuroscience and the Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544469PMC
July 2019

A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity.

Cell Host Microbe 2019 07 2;26(1):114-122.e8. Epub 2019 Jul 2.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649664PMC
July 2019

Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers.

Neurogastroenterol Motil 2019 Jun 4;31(6):e13585. Epub 2019 Apr 4.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1111/nmo.13585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522279PMC
June 2019

Neuronal FcγRI mediates acute and chronic joint pain.

J Clin Invest 2019 Jun 18;130:3754-3769. Epub 2019 Jun 18.

Department of Neurosurgery and Neurosurgery Pain Research Institute.

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http://dx.doi.org/10.1172/JCI128010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715360PMC
June 2019

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice.

Mol Metab 2019 May 7;23:75-81. Epub 2019 Mar 7.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479763PMC
May 2019

Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.

Immunity 2019 05 23;50(5):1163-1171.e5. Epub 2019 Apr 23.

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531358PMC
May 2019

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.

Proc Natl Acad Sci U S A 2019 May 8;116(21):10525-10530. Epub 2019 May 8.

Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;

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http://dx.doi.org/10.1073/pnas.1903316116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535009PMC
May 2019

Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy.

Sci Rep 2019 May 21;9(1):7651. Epub 2019 May 21.

Institute of Basic Medical Sciences, Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.

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http://www.nature.com/articles/s41598-019-44172-9
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http://dx.doi.org/10.1038/s41598-019-44172-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529466PMC
May 2019

Sphingosine-1-phosphate activates mouse vagal airway afferent C-fibres via S1PR3 receptors.

J Physiol 2019 Apr 21;597(7):2007-2019. Epub 2019 Feb 21.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1113/JP277521
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http://dx.doi.org/10.1113/JP277521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441905PMC
April 2019

Cholestatic pruritus: Emerging mechanisms and therapeutics.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.04.035DOI Listing
April 2019

Role of P2X3 receptors in scratching behavior in mouse models.

J Allergy Clin Immunol 2019 Mar 17;143(3):1252-1254.e8. Epub 2018 Nov 17.

Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183160
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http://dx.doi.org/10.1016/j.jaci.2018.10.053DOI Listing
March 2019

STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice.

Cell Res 2019 Feb 3;29(2):95-109. Epub 2019 Jan 3.

State Key Laboratory of Membrane Biology; Tsinghua-Peking Joint Center for Life Sciences; IDG/McGovern Institute for Brain Research; School of Pharmaceutical Sciences, Tsinghua University, 100084, Beijing, China.

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http://www.nature.com/articles/s41422-018-0129-0
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http://dx.doi.org/10.1038/s41422-018-0129-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355819PMC
February 2019

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.

Neuron 2019 02 24;101(3):412-420.e3. Epub 2019 Jan 24.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462816PMC
February 2019

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.

FASEB J 2019 01 27;33(1):1360-1373. Epub 2018 Aug 27.

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China.

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http://dx.doi.org/10.1096/fj.201800615RRDOI Listing
January 2019

Identification of a bilirubin receptor that may mediate a component of cholestatic itch.

Elife 2019 Jan 21;8. Epub 2019 Jan 21.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.

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http://dx.doi.org/10.7554/eLife.44116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368403PMC
January 2019

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.

Am J Physiol Endocrinol Metab 2018 09 29;315(3):E357-E366. Epub 2018 May 29.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1152/ajpendo.00024.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171009PMC
September 2018

Matrine inhibits itching by lowering the activity of calcium channel.

Sci Rep 2018 07 27;8(1):11328. Epub 2018 Jul 27.

State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.

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http://dx.doi.org/10.1038/s41598-018-28661-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063846PMC
July 2018

Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats.

Anesthesiology 2018 06;128(6):1220-1236

From the Department of Anesthesiology and Critical Care Medicine (Vinod T., M.A., F.Y., Vineeta T., S.-Q.H., T.Z., B.S., S.A.G., Z.C., S.N.R., Y.G.) the Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology (M.A., Q.Z., X.D.) Department of Pharmacology and Molecular Sciences and the Center for Epigenetics (K.E.S.) the Howard Hughes Medical Institute (X.D.), Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, Gujarat, India (Vinod T.) Department of Neurology, Tiantan Hospital, Capital Medical University, Beijing, China (T.Z.) Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Wuhan, China (B.S.) the Department of Orthopedics, Luhe Hospital, Capital Medical University, Beijing, China (X.C.).

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http://dx.doi.org/10.1097/ALN.0000000000002191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953805PMC
June 2018

Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia.

Sci Signal 2018 06 19;11(535). Epub 2018 Jun 19.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scisignal.aao3134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328051PMC
June 2018

Peripheral and Central Mechanisms of Itch.

Neuron 2018 05;98(3):482-494

The Solomon H. Snyder Department of Neuroscience and the Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022762PMC
May 2018

Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

Nat Neurosci 2018 03 5;21(3):324-328. Epub 2018 Feb 5.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41593-018-0074-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857222PMC
March 2018

Investigation of Pain Mechanisms by Calcium Imaging Approaches.

Neurosci Bull 2018 Feb 13;34(1):194-199. Epub 2017 May 13.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s12264-017-0139-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799123PMC
February 2018

Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.

Biochem Pharmacol 2018 02 21;148:147-154. Epub 2017 Dec 21.

School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.12.017DOI Listing
February 2018

MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions.

Biochem Pharmacol 2017 12 4;146:214-223. Epub 2017 Oct 4.

School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.09.017DOI Listing
December 2017

Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation.

Annu Rev Genet 2017 11;51:103-121

The Solomon H. Snyder Department of Neuroscience and the Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA; email: ,

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http://dx.doi.org/10.1146/annurev-genet-120116-024723DOI Listing
November 2017

Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.

Adv Exp Med Biol 2016;904:87-103

Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/978-94-017-7537-3_7DOI Listing
July 2017

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.

Neuron 2017 Apr;94(2):337-346.e6

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007997PMC
April 2017

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.

Proc Natl Acad Sci U S A 2017 03 21;114(10):E1996-E2005. Epub 2017 Feb 21.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

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http://dx.doi.org/10.1073/pnas.1615255114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347560PMC
March 2017

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord.

Neuron 2017 Feb;93(4):840-853.e5

The Solomon H. Snyder Department of Neuroscience and Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324710PMC
February 2017

miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats.

Sci Rep 2016 12 6;6:38285. Epub 2016 Dec 6.

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

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http://dx.doi.org/10.1038/srep38285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138852PMC
December 2016

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation.

Pain 2016 11;157(11):2582-2593

aDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA bThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA cHoward Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA dDepartment of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China eNeuromodulation Research, Medtronic Inc., Minneapolis, MN, USA fDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden gDepartment of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069149PMC
http://dx.doi.org/10.1097/j.pain.0000000000000680DOI Listing
November 2016

In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP.

Sci Adv 2016 Nov 11;2(11):e1600990. Epub 2016 Nov 11.

Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1126/sciadv.1600990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106201PMC
November 2016

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain.

Neuron 2016 Sep 25;91(5):1085-1096. Epub 2016 Aug 25.

Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017920PMC
September 2016

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons.

Cell Stem Cell 2016 07 16;19(1):95-106. Epub 2016 Jun 16.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996639PMC
July 2016

Trp channels and itch.

Semin Immunopathol 2016 05 18;38(3):293-307. Epub 2015 Sep 18.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA.

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http://link.springer.com/10.1007/s00281-015-0530-4
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http://dx.doi.org/10.1007/s00281-015-0530-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798920PMC
May 2016

Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.

Respir Res 2016 05 23;17(1):62. Epub 2016 May 23.

School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, 6009, Australia.

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http://dx.doi.org/10.1186/s12931-016-0378-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877944PMC
May 2016

Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.

Brain Res 2016 Apr 10;1636:161-171. Epub 2016 Feb 10.

College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2016.02.014DOI Listing
April 2016

The cell biology of acute itch.

J Cell Biol 2016 04;213(2):155-61

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21205

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http://www.jcb.org/lookup/doi/10.1083/jcb.201603042
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http://dx.doi.org/10.1083/jcb.201603042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862869PMC
April 2016

Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain.

Anesthesiology 2016 Mar;124(3):706-20

From the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland (Vinod Tiwari, F.Y., S.-Q.H., R.S., B.S., Vineeta Tiwari, Y.G., S.N.R.); Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (C.Z., Y.W.); Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Wuhan, China (B.S.); Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (T.Z.); The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland (X.D.); and Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland (X.D.).

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http://dx.doi.org/10.1097/ALN.0000000000000993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755859PMC
March 2016

Pirt contributes to uterine contraction-induced pain in mice.

Mol Pain 2015 Sep 17;11:57. Epub 2015 Sep 17.

College of Basic Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, 210023, Jiangsu, China.

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http://dx.doi.org/10.1186/s12990-015-0054-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574137PMC
September 2015

Supporting itch: a new role for astrocytes in chronic itch.

Nat Med 2015 Aug;21(8):841-2

Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology and the Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://www.nature.com/articles/nm.3921
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http://dx.doi.org/10.1038/nm.3921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053542PMC
August 2015

The role of the Mrgpr receptor family in itch.

Handb Exp Pharmacol 2015 ;226:71-88

The Center for the Study of Itch, Washington University Pain Center, St. Louis, MO, 63110, USA,

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http://dx.doi.org/10.1007/978-3-662-44605-8_5DOI Listing
July 2015

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.

Nat Commun 2015 Jul 28;6:7864. Epub 2015 Jul 28.

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncomms8864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520244PMC
July 2015

Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice.

Pain 2015 Jun;156(6):1008-17

aDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA bThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA cHoward Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA dDepartment of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

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http://pdfs.journals.lww.com/pain/2015/06000/Electrical_stim
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/01.j.pain.0000460353.15460.a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437220PMC
June 2015

Selective keratinocyte stimulation is sufficient to evoke nociception in mice.

Pain 2015 Apr;156(4):656-65

Departments of aNeurosurgery bBiological Chemistry cNeuroscience dNeurosurgery Pain Research Institute eCenter for Sensory Biology fDepartment of Anesthesiology and Critical Care Medicine gHoward Hughes Medical Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA hDepartment of Biology, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000092DOI Listing
April 2015

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.

Nature 2015 Mar 17;519(7542):237-41. Epub 2014 Dec 17.

1] The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA [2] Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature14022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359082PMC
March 2015

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.

Neuron 2015 Feb 29;85(4):833-46. Epub 2015 Jan 29.

Departments of Neuroscience and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.12.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336228PMC
February 2015

Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.

ChemMedChem 2015 Jan 10;10(1):57-61. Epub 2014 Sep 10.

Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Specialized Chemistry Center (MLPCN), Vanderbilt University Medical Center, Nashville, TN 37232-6600 (USA).

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http://dx.doi.org/10.1002/cmdc.201402277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276534PMC
January 2015

Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats.

Neuromodulation 2015 Jan 10;18(1):33-40; discussion 40. Epub 2014 Oct 10.

Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/ner.12249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333027PMC
January 2015

Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

Bioorg Med Chem 2014 Nov 19;22(21):5831-7. Epub 2014 Sep 19.

Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United States; Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254045PMC
November 2014

Generation of multipotent induced neural crest by direct reprogramming of human postnatal fibroblasts with a single transcription factor.

Cell Stem Cell 2014 Oct 21;15(4):497-506. Epub 2014 Aug 21.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.07.013DOI Listing
October 2014

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice.

Pain 2014 Aug 9;155(8):1613-21. Epub 2014 May 9.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104261PMC
August 2014

Itch mechanisms and circuits.

Annu Rev Biophys 2014 ;43:331-55

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology.

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http://dx.doi.org/10.1146/annurev-biophys-051013-022826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081479PMC
August 2014

Three functionally distinct classes of C-fibre nociceptors in primates.

Nat Commun 2014 Jun 20;5:4122. Epub 2014 Jun 20.

Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072246PMC
June 2014

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.

Brain 2014 Apr 18;137(Pt 4):1039-50. Epub 2014 Feb 18.

1 Department of Anaesthesiology, Yale University School of Medicine, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1093/brain/awu007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959553PMC
April 2014

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain.

Pain 2014 Mar 11;155(3):534-44. Epub 2013 Dec 11.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2013.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945061PMC
March 2014

Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain.

Neuron 2014 Feb 23;81(4):873-887. Epub 2014 Jan 23.

Department of Neuroscience, Center of Sensory Biology, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943838PMC
February 2014

Pirt functions as an endogenous regulator of TRPM8.

Nat Commun 2013 ;4:2179

Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210046, PR China.

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http://dx.doi.org/10.1038/ncomms3179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748931PMC
January 2014

Sensory neurons and circuits mediating itch.

Nat Rev Neurosci 2014 Jan;15(1):19-31

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/nrn3641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096293PMC
January 2014

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats.

Pain 2013 Nov 20;154(11):2477-86. Epub 2013 Jul 20.

Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.pain.2013.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863910PMC
November 2013

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.

Nat Neurosci 2013 Aug 23;16(8):1024-31. Epub 2013 Jun 23.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nn.3438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742386PMC
August 2013

A subpopulation of nociceptors specifically linked to itch.

Nat Neurosci 2013 Feb 23;16(2):174-82. Epub 2012 Dec 23.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nn.3289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557753PMC
February 2013

Mechanisms of itch evoked by β-alanine.

J Neurosci 2012 Oct;32(42):14532-7

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3509-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491570PMC
October 2012

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.

J Clin Invest 2012 Jun 8;122(6):2195-207. Epub 2012 May 8.

Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI45414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366391PMC
June 2012

Peripheral mechanisms of itch.

Neurosci Bull 2012 Apr;28(2):100-10

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1007/s12264-012-1202-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560392PMC
April 2012

Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.

PLoS One 2011 31;6(5):e20559. Epub 2011 May 31.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020559PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105090PMC
October 2011

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.

Sci Signal 2011 Jul 12;4(181):ra45. Epub 2011 Jul 12.

Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scisignal.2001925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144551PMC
July 2011

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.

Nat Neurosci 2011 May 3;14(5):595-602. Epub 2011 Apr 3.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1038/nn.2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181150PMC
May 2011

BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

J Neurosci 2011 May;31(20):7563-7

Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1192-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111068PMC
May 2011

Itch: Cells, Molecules, and Circuits.

ACS Chem Neurosci 2011 Jan;2(1):17-25

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/cn100085gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123905PMC
January 2011

An itch to be scratched.

Neuron 2010 Nov;68(3):334-9

The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662731000868
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http://dx.doi.org/10.1016/j.neuron.2010.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111050PMC
November 2010

Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

Proc Natl Acad Sci U S A 2010 Sep 19;107(36):15933-8. Epub 2010 Aug 19.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1011221107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936626PMC
September 2010

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.

Cell 2009 Dec 10;139(7):1353-65. Epub 2009 Dec 10.

The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.cell.2009.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989405PMC
December 2009