Publications by authors named "Xingxuan He"

43Publications

The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis.

Front Pharmacol 2018 8;9:1504. Epub 2019 Jan 8.

Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.01504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338044PMC
January 2019

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy.

Invest Ophthalmol Vis Sci 2018 11;59(13):5391-5397

Molecular Ophthalmology, Department of Ophthalmology, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.18-25466DOI Listing
November 2018

Ceramide and Ischemia/Reperfusion Injury.

J Lipids 2018 21;2018:3646725. Epub 2018 Jan 21.

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/3646725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828470PMC
January 2018

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.

BBA Clin 2017 Jun 13;7:85-96. Epub 2017 Feb 13.

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbacli.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338723PMC
June 2017

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.

Biochim Biophys Acta Mol Basis Dis 2017 02 1;1863(2):386-394. Epub 2016 Dec 1.

Institute of Medical Science, University of Toronto, Toronto M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto M5G 1L7, Canada; University Health Network, Toronto M5G 1L7, Canada; Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2016.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192210PMC
February 2017

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.

J Lipid Res 2016 09 29;57(9):1696-711. Epub 2016 Jul 29.

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, TX

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M069526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003156PMC
September 2016

The molecular medicine of acid ceramidase.

Biol Chem 2015 Jun;396(6-7):759-65

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/hsz-2014-0290DOI Listing
June 2015

Ceramide is upregulated and associated with mortality in patients with chronic heart failure.

Can J Cardiol 2015 Mar 11;31(3):357-63. Epub 2014 Dec 11.

Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2014.12.007DOI Listing
March 2015

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.

Nat Commun 2014 Nov 24;5:5514. Epub 2014 Nov 24.

1] Stem Cell Neuroplasticity Research Group, Kyungpook National University, Daegu 702-701, Korea [2] Department of Laboratory Animal Medicine, Cell and Matrix Research Institute, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263144PMC
November 2014

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease.

J Exp Med 2014 Jul 21;211(8):1551-70. Epub 2014 Jul 21.

Stem Cell Neuroplasticity Research Group, Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, KoreaStem Cell Neuroplasticity Research Group, Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, KoreaStem Cell Neuroplasticity Research Group, Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Department of Biomedical Science, BK21 Plus KNU Biomedical Convergence Program, Department of Laboratory Animal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20132451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113944PMC
July 2014

Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes.

Coron Artery Dis 2014 May;25(3):230-5

aDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha bThe State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University cDepartment of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China dDepartment of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCA.0000000000000079DOI Listing
May 2014

Recombinant human acid sphingomyelinase as an adjuvant to sorafenib treatment of experimental liver cancer.

PLoS One 2013 28;8(5):e65620. Epub 2013 May 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665770PMC
January 2014

Potential role of acid sphingomyelinase in environmental health.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012 Feb;37(2):109-25

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://doi.med.wanfangdata.com.cn/10.3969/j.issn.1672-7347.2
Publisher Site
http://dx.doi.org/10.3969/j.issn.1672-7347.2012.02.001DOI Listing
February 2012

Identification of cystatin SA as a novel inhibitor of acid ceramidase.

J Biol Chem 2011 Oct 16;286(41):35624-33. Epub 2011 Aug 16.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M111.260372
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.260372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195560PMC
October 2011

Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.

Cell Physiol Biochem 2010 29;26(4-5):749-60. Epub 2010 Oct 29.

Department of Genetics & Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/322342
Publisher Site
http://dx.doi.org/10.1159/000322342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048941PMC
March 2011

Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease.

Mol Med 2010 Jul-Aug;16(7-8):316-21. Epub 2010 Apr 6.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, New York 10029, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2010.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896470PMC
November 2010

Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses.

Proc Natl Acad Sci U S A 2010 Jan 14;107(1):222-7. Epub 2009 Dec 14.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0912937107
Publisher Site
http://dx.doi.org/10.1073/pnas.0912937107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806747PMC
January 2010

Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.

FASEB J 2010 Apr 9;24(4):1229-38. Epub 2009 Dec 9.

Department of Genetics and Genomic Sciences, Mt. Sinai School of Medicine, 1425 Madison Ave., Rm. 14-20A, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.09-145508
Publisher Site
http://dx.doi.org/10.1096/fj.09-145508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231947PMC
April 2010

Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.

Med Sci Monit 2009 Sep;15(9):BR254-61

Department of Endocrinology, Xiangya Hospital of Central South University, Hunan Province, Changsha, China.

View Article

Download full-text PDF

Source
September 2009

Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Apr 27;877(10):983-90. Epub 2009 Feb 27.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S157002320900143
Publisher Site
http://dx.doi.org/10.1016/j.jchromb.2009.02.048DOI Listing
April 2009

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models.

Mol Genet Metab 2008 Nov 23;95(3):152-62. Epub 2008 Sep 23.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2008.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621017PMC
November 2008

Deregulation of sphingolipid metabolism in Alzheimer's disease.

Neurobiol Aging 2010 Mar 10;31(3):398-408. Epub 2008 Jun 10.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2008.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829762PMC
March 2010

Autoproteolytic cleavage and activation of human acid ceramidase.

J Biol Chem 2008 Apr 14;283(17):11253-9. Epub 2008 Feb 14.

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M709166200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431059PMC
April 2008

Acid ceramidase is a novel factor required for early embryo survival.

FASEB J 2007 May 30;21(7):1403-9. Epub 2007 Jan 30.

Department of Human Genetics, Mt. Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.06-7016comDOI Listing
May 2007

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death.

J Lipid Res 2005 Nov 8;46(11):2315-24. Epub 2005 Sep 8.

Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M500136-JLR200DOI Listing
November 2005

Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase.

Anal Biochem 2005 May;340(1):113-22

Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2005.01.058DOI Listing
May 2005

Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase.

J Biol Chem 2003 Aug 18;278(35):32978-86. Epub 2003 Jun 18.

Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M301936200DOI Listing
August 2003

The reverse activity of human acid ceramidase.

J Biol Chem 2003 Aug 22;278(32):29948-53. Epub 2003 May 22.

Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/278/32/29948.full.pdf
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M303310200
Publisher Site
http://dx.doi.org/10.1074/jbc.M303310200DOI Listing
August 2003

A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease.

Anal Biochem 2003 Mar;314(1):116-20

Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0003-2697(02)00629-2DOI Listing
March 2003

Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice.

Am J Pathol 2002 Sep;161(3):1061-75

Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867239PMC
http://dx.doi.org/10.1016/S0002-9440(10)64267-8DOI Listing
September 2002

A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism.

Anal Biochem 2002 Jul;306(1):115-23

Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1006/abio.2002.5686DOI Listing
July 2002