Xingnan Li

Xingnan Li

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Xingnan Li

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Hot Topic: Precision Medicine for Asthma-Has the Time Come?

Authors:
Xingnan Li

Curr Allergy Asthma Rep 2019 Sep 5;19(10):45. Epub 2019 Sep 5.

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, 1230 N Cherry Avenue, PO Box 210242, Tucson, AZ, 85719, USA.

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http://dx.doi.org/10.1007/s11882-019-0881-3DOI Listing
September 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Chemical Markers for Short- and Long-Term Areca Nut Exposure.

Subst Use Misuse 2019 Jun 27:1-8. Epub 2019 Jun 27.

a Analytical Biochemistry Shared Resource, University of Hawaii Cancer Center , Honolulu , Hawaii , USA.

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http://dx.doi.org/10.1080/10826084.2019.1630442DOI Listing
June 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.

Cell Rep 2019 Feb;26(9):2509-2520.e4

Department of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391775PMC
February 2019

Oxytocin analysis from human serum, urine, and saliva by orbitrap liquid chromatography-mass spectrometry.

Drug Test Anal 2019 Jan 11;11(1):119-128. Epub 2018 Sep 11.

University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, USA.

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http://dx.doi.org/10.1002/dta.2475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349498PMC
January 2019

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Am J Clin Nutr 2018 12;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1093/ajcn/nqy274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693398PMC
December 2018

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 09;50(9):1343

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0197-6DOI Listing
September 2018

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.

Nat Genet 2018 08 16;50(8):1072-1080. Epub 2018 Jul 16.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41588-018-0157-1DOI Listing
August 2018

Genome-wide association study of lung function and clinical implication in heavy smokers.

BMC Med Genet 2018 08 1;19(1):134. Epub 2018 Aug 1.

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, BioScience Research Lab, Room 253, 1230 N. Cherry Avenue, PO Box 210242, Tucson, AZ, 85721, USA.

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http://dx.doi.org/10.1186/s12881-018-0656-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090900PMC
August 2018

An Air-Liquid Interface Culture System for 3D Organoid Culture of Diverse Primary Gastrointestinal Tissues.

Methods Mol Biol 2016 ;1422:33-40

Hematology Division, Department of Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/978-1-4939-3603-8_4DOI Listing
December 2017

The value of blood cytokines and chemokines in assessing COPD.

Respir Res 2017 10 24;18(1):180. Epub 2017 Oct 24.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, 1400 Jackson St., K715, Denver, CO, 80206, USA.

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http://dx.doi.org/10.1186/s12931-017-0662-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655820PMC
October 2017

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Nature 2017 05 3;545(7653):234-237. Epub 2017 May 3.

Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, and Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature22306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815871PMC
May 2017

Pilot study of the pharmacokinetics of betel nut and betel quid biomarkers in saliva, urine, and hair of betel consumers.

Drug Test Anal 2016 Oct 1;8(10):1095-1099. Epub 2015 Dec 1.

University of Hawai'i Cancer Center, Honolulu, HI, 96813, USA.

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http://dx.doi.org/10.1002/dta.1912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967029PMC
October 2016

Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV.

J Neuroimmune Pharmacol 2016 09 12;11(3):549-61. Epub 2016 Apr 12.

Department of Medicine, John A. Burns School of Medicine, University of Hawai'i and Queen's Medical Center, 1356 Lusitana Street, 7th Floor, Room 716, Honolulu, HI, 96813, USA.

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http://dx.doi.org/10.1007/s11481-016-9668-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502481PMC
September 2016

Improved profiling of estrogen metabolites by orbitrap LC/MS.

Steroids 2015 Jul 25;99(Pt A):84-90. Epub 2014 Dec 25.

University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446197PMC
July 2015

Improvement of bisphenol A quantitation from urine by LCMS.

Anal Bioanal Chem 2015 May 27;407(13):3869-74. Epub 2015 Feb 27.

University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI, 96813, USA,

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http://dx.doi.org/10.1007/s00216-015-8563-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439252PMC
May 2015

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis.

J Allergy Clin Immunol 2014 Jun 9;133(6):1557-63.e5. Epub 2013 Dec 9.

Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research and the Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston-Salem, NC.

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http://dx.doi.org/10.1016/j.jaci.2013.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040309PMC
June 2014

Clinical heterogeneity in the severe asthma research program.

Ann Am Thorac Soc 2013 Dec;10 Suppl:S118-24

1 Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, North Carolina; and.

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http://dx.doi.org/10.1513/AnnalsATS.201309-307AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960988PMC
December 2013

Within-person reproducibility of urinary bisphenol A and phthalate metabolites over a 1 to 3 year period among women in the Nurses' Health Studies: a prospective cohort study.

Environ Health 2013 Sep 13;12(1):80. Epub 2013 Sep 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1476-069X-12-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847616PMC
September 2013

Genetics of asthma susceptibility and severity.

Clin Chest Med 2012 Sep 7;33(3):431-43. Epub 2012 Jul 7.

Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S027252311200063
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http://dx.doi.org/10.1016/j.ccm.2012.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431509PMC
September 2012

The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.

J Allergy Clin Immunol 2012 Aug 1;130(2):510-5.e1. Epub 2012 May 1.

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409329PMC
August 2012

High-throughput and cost-effective global DNA methylation assay by liquid chromatography-mass spectrometry.

Anal Chim Acta 2011 Oct 19;703(1):58-63. Epub 2011 Jul 19.

University of Hawaii Cancer Center, Honolulu, 96813, USA.

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http://dx.doi.org/10.1016/j.aca.2011.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439212PMC
October 2011

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Nat Genet 2011 Jul 31;43(9):887-92. Epub 2011 Jul 31.

Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445408PMC
http://dx.doi.org/10.1038/ng.888DOI Listing
July 2011

Improved LC-MS method for the determination of fatty acids in red blood cells by LC-orbitrap MS.

Anal Chem 2011 Apr 23;83(8):3192-8. Epub 2011 Mar 23.

Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA.

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http://pubs.acs.org/doi/abs/10.1021/ac103093w
Publisher Site
http://dx.doi.org/10.1021/ac103093wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439250PMC
April 2011

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.

J Allergy Clin Immunol 2010 Feb;125(2):328-335.e11

Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824608PMC
February 2010

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

Nat Med 2009 Jun 27;15(6):701-6. Epub 2009 Apr 27.

Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nm.1951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919216PMC
June 2009

Fast HPLC-ECD analysis of ascorbic acid, dehydroascorbic acid and uric acid.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Apr 11;877(10):853-6. Epub 2009 Feb 11.

Cancer Research Center of Hawaii, Natural Products & Cancer Biology Program, 1236 Lauhala Street, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1016/j.jchromb.2009.02.008DOI Listing
April 2009

Phytoestrogenic isoflavonoids in epidemiologic and clinical research.

Drug Test Anal 2009 Jan;1(1):14-21

Cancer Research Center of Hawai'i, Natural Products and Cancer Biology Program, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1002/dta.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439247PMC
January 2009

DNA copy number alterations in prostate cancers: a combined analysis of published CGH studies.

Prostate 2007 May;67(7):692-700

Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1002/pros.20543DOI Listing
May 2007

IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma.

Immunogenetics 2006 Oct 5;58(10):851-5. Epub 2006 Oct 5.

Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.

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http://dx.doi.org/10.1007/s00251-006-0146-xDOI Listing
October 2006

Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors.

Bioorg Med Chem 2006 Aug 5;14(16):5742-55. Epub 2006 Jun 5.

Center for Drug Design, Academic Health Center, and Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, 55455, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.04.011DOI Listing
August 2006

Conformationally restrained carbazolone-containing alpha,gamma-diketo acids as inhibitors of HIV integrase.

Bioorg Med Chem 2006 May 4;14(9):2942-55. Epub 2006 Jan 4.

Department of Medicinal Chemistry, College of Pharmacy, and Center for Drug Design, Academic Health Center, University of Minnesota, 8-123A WDH, 308 Harvard Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.12.013DOI Listing
May 2006

KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia.

Cancer Biol Ther 2005 Dec 23;4(12):1401-8. Epub 2005 Dec 23.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294-3300, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361751PMC
http://dx.doi.org/10.4161/cbt.4.12.2355DOI Listing
December 2005

Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation.

Cancer Res 2002 Oct;62(20):5867-73

Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, 35294, USA.

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October 2002