Xing-Xing Fan

Xing-Xing Fan

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Xing-Xing Fan

Xing-Xing Fan

Publications by authors named "Xing-Xing Fan"

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30Publications

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miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway.

Int J Oncol 2020 Feb 13;56(2):470-479. Epub 2019 Dec 13.

Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.

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http://dx.doi.org/10.3892/ijo.2019.4940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959373PMC
February 2020

Characterization of an Anti-CD5 Directed CAR T-Cell against T-Cell Malignancies.

Stem Cell Rev Rep 2020 Feb 1. Epub 2020 Feb 1.

iCell Gene Therapeutics LLC Research & Development Division, Long Island High Technology Incubator, 25 Health Sciences Drive, Stony Brook, NY, 11790, USA.

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http://dx.doi.org/10.1007/s12015-019-09937-9DOI Listing
February 2020

Targeting Two Antigens Associated with B-ALL with CD19-CD123 Compound Car T Cell Therapy.

Stem Cell Rev Rep 2020 Jan 22. Epub 2020 Jan 22.

Division of Blood and Bone Marrow Transplantation, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

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http://dx.doi.org/10.1007/s12015-019-09948-6DOI Listing
January 2020

Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer.

Phytomedicine 2019 Dec 27;65:153100. Epub 2019 Sep 27.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.153100DOI Listing
December 2019

MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3'UTR and predicts poor survival in non-small cell lung cancer.

Cell Death Dis 2019 Oct 28;10(11):821. Epub 2019 Oct 28.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, China.

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http://dx.doi.org/10.1038/s41419-019-2031-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817891PMC
October 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer.

Int J Cancer 2019 09 12;145(5):1334-1345. Epub 2019 Mar 12.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau (SAR), China.

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
September 2019

Long-term efficacy of Chinese medicine Bushen Capsule on cognition and brain activity in patients with amnestic mild cognitive impairment.

Pharmacol Res 2019 08 17;146:104319. Epub 2019 Jun 17.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, PR China; BABRI Centre, Beijing Normal University, Beijing 100875, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104319DOI Listing
August 2019

p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling.

Cancer Cell Int 2019 19;19:188. Epub 2019 Jul 19.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao, China.

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http://dx.doi.org/10.1186/s12935-019-0910-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642601PMC
July 2019

Identification of a new pyruvate kinase M2 isoform (PKM2) activator for the treatment of non-small-cell lung cancer (NSCLC).

Chem Biol Drug Des 2018 11 10;92(5):1851-1858. Epub 2018 Jul 10.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.

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http://dx.doi.org/10.1111/cbdd.13354DOI Listing
November 2018

Novel therapeutic strategy for cancer and autoimmune conditions: Modulating cell metabolism and redox capacity.

Pharmacol Ther 2018 11 25;191:148-161. Epub 2018 Jun 25.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.06.010DOI Listing
November 2018

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation.

Cell Death Dis 2018 06 13;9(6):696. Epub 2018 Jun 13.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.

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http://dx.doi.org/10.1038/s41419-018-0733-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999972PMC
June 2018

Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases.

Antioxid Redox Signal 2018 02 4;28(5):339-357. Epub 2017 Aug 4.

1 State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology , Macau (SAR), China .

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http://dx.doi.org/10.1089/ars.2017.7090DOI Listing
February 2018

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity.

Cell Death Dis 2018 02 13;9(2):216. Epub 2018 Feb 13.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.

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http://dx.doi.org/10.1038/s41419-017-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833846PMC
February 2018

Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells.

Front Pharmacol 2017 14;8:823. Epub 2017 Nov 14.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.

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http://dx.doi.org/10.3389/fphar.2017.00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694459PMC
November 2017

Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.

Oncotarget 2017 Nov 9;8(56):96089-96102. Epub 2017 Oct 9.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.

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http://www.oncotarget.com/fulltext/21716
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http://dx.doi.org/10.18632/oncotarget.21716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707083PMC
November 2017

Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer.

Medchemcomm 2017 Oct 25;8(10):1914-1918. Epub 2017 Aug 25.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health , Macau University of Science and Technology , Macau SAR , China . Email: ; Email: ; Email: ; ; Tel: +853 8897 2409.

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http://dx.doi.org/10.1039/c7md00305fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071718PMC
October 2017

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.

Front Pharmacol 2017 11;8:199. Epub 2017 Apr 11.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and TechnologyMacau, China.

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http://dx.doi.org/10.3389/fphar.2017.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387050PMC
April 2017

Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells.

Medchemcomm 2017 Mar 26;8(3):621-624. Epub 2017 Jan 26.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health , Macau University of Science and Technology , Macau SAR , China . Email: ; Email: ; Email: ; ; Tel: +853 8897 2438.

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http://dx.doi.org/10.1039/c6md00643dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071735PMC
March 2017

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.

Pharmacol Res 2017 01 15;115:45-55. Epub 2016 Nov 15.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.11.011DOI Listing
January 2017

Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.

Int J Oncol 2016 Oct 3;49(4):1576-88. Epub 2016 Aug 3.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.R. China.

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http://dx.doi.org/10.3892/ijo.2016.3644DOI Listing
October 2016

Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations.

Oncol Rep 2016 Jul 26;36(1):365-75. Epub 2016 Apr 26.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, P.R. China.

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http://dx.doi.org/10.3892/or.2016.4770DOI Listing
July 2016

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma.

Oncotarget 2016 Jun;7(26):39970-39979

State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The 1st Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.9461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129985PMC
June 2016

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.

Molecules 2016 Mar 18;21(3):374. Epub 2016 Mar 18.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.

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http://dx.doi.org/10.3390/molecules21030374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274445PMC
March 2016

Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.

Antioxid Redox Signal 2016 Feb 14;24(5):263-79. Epub 2015 Dec 14.

1 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology , Macau (SAR), China .

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http://dx.doi.org/10.1089/ars.2015.6420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753639PMC
February 2016

Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS.

Talanta 2015 Nov 19;144:20-8. Epub 2015 May 19.

State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140150037
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http://dx.doi.org/10.1016/j.talanta.2015.05.017DOI Listing
November 2015

Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.

Molecules 2014 Mar 21;19(3):3508-22. Epub 2014 Mar 21.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau SAR, China.

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http://dx.doi.org/10.3390/molecules19033508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271537PMC
March 2014

SiRNA targeting EGFR effectively prevents posterior capsular opacification after cataract surgery.

Mol Vis 2011 31;17:2349-55. Epub 2011 Aug 31.

Tianjin Eye Hospital, Tianjin Medical University, Tianjin, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171494PMC
January 2012