Xing-Mei Zhang

Xing-Mei Zhang

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Xing-Mei Zhang

Publications by authors named "Xing-Mei Zhang"

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Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice.

Glia 2020 Feb 10. Epub 2020 Feb 10.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/glia.23794DOI Listing
February 2020

The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease.

Nucleic Acid Ther 2019 Dec 12;29(6):359-366. Epub 2019 Sep 12.

Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1089/nat.2019.0812DOI Listing
December 2019

Resveratrol improves cognition and decreases amyloid plaque formation in Tg6799 mice.

Mol Med Rep 2019 May 6;19(5):3783-3790. Epub 2019 Mar 6.

Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

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http://dx.doi.org/10.3892/mmr.2019.10010DOI Listing
May 2019

Features of repeated muscle biopsies and phenotypes of monocytes in paired blood samples and clinical long-term response to treatment in patients with idiopathic inflammatory myopathy: a pilot study.

Clin Exp Rheumatol 2020 Jan-Feb;38(1):42-49. Epub 2019 May 22.

Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Division of Rheumatology, Karolinska University Hospital, Solna, Stockholm, Sweden.

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May 2019

Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders.

Glia 2019 02 30;67(2):217-231. Epub 2018 Oct 30.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital at Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1002/glia.23529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635749PMC
February 2019

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells.

Nat Commun 2018 11 19;9(1):4845. Epub 2018 Nov 19.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital Solna, Stockholm, 17176, Sweden.

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http://dx.doi.org/10.1038/s41467-018-07295-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242869PMC
November 2018

Alterations of secondary sex characteristics, reproductive histology and behaviors by norgestrel in the western mosquitofish (Gambusia affinis).

Aquat Toxicol 2018 May 13;198:224-230. Epub 2018 Mar 13.

The Environmental Research Institute, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0166445X183004
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http://dx.doi.org/10.1016/j.aquatox.2018.03.014DOI Listing
May 2018

Multifunctional superparamagnetic nanoparticles conjugated with fluorescein-labeled designed ankyrin repeat protein as an efficient HER2-targeted probe in breast cancer.

Biomaterials 2017 Dec 8;147:86-98. Epub 2017 Sep 8.

Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.09.010DOI Listing
December 2017

Large vein injection alleviates rocuronium-induced pain in gynaecologic patients.

Anaesth Crit Care Pain Med 2017 Aug 30;36(4):233-235. Epub 2016 Jul 30.

Department of anaesthesiology, Wuxi maternity and child health hospital, Nanjing Medical University, 48, Huaishu-Xiang Wuxi, 214002 Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2016.03.010DOI Listing
August 2017

An updated assessment of microglia depletion: current concepts and future directions.

Mol Brain 2017 06 19;10(1):25. Epub 2017 Jun 19.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital at Solna, CMM L8:04, Karolinska Sjukhuset, S-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13041-017-0307-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477141PMC
June 2017

Tissue Engineering in Gene and Cell Therapies for Neurological Disorders.

Biomed Res Int 2016 20;2016:8738504. Epub 2016 Apr 20.

Laboratory for Translational Research, Harvard Medical School, Cambridge, MA 02215, USA.

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http://dx.doi.org/10.1155/2016/8738504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854986PMC
February 2017

Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-β.

Immunol Cell Biol 2016 09 10;94(8):747-62. Epub 2016 May 10.

Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, & Science for Life Laboratory, Stockholm, Sweden.

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http://dx.doi.org/10.1038/icb.2016.34DOI Listing
September 2016

Establishing a Proteomics-Based Monocyte Assay To Assess Differential Innate Immune Activation Responses.

J Proteome Res 2016 07 3;15(7):2337-45. Epub 2016 Jun 3.

Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Hospital, Karolinska Institutet , SE 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.jproteome.6b00422DOI Listing
July 2016

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.

J Exp Med 2016 07 18;213(8):1537-53. Epub 2016 Jul 18.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna, S-171 76 Stockholm, Sweden

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http://dx.doi.org/10.1084/jem.20150577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986521PMC
July 2016

[ApoE4 increases glycogen synthase kinase 3β expression and Tau phosphorylation in U87 cells].

Nan Fang Yi Ke Da Xue Xue Bao 2016 Jun;36(7):904-8

Department of Neurobiology, College of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.E-mail:

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June 2016

Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis.

Neurosci Lett 2016 05 23;620:1-7. Epub 2016 Mar 23.

Applied Immunology & Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2016.03.037DOI Listing
May 2016

A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura.

J Forensic Sci 2016 Jan;61(1):288

Applied Immunology & Immunotherapy, Center for Molecular Medicine, Karolinska University Hospital at Solna, Department of Clinical Neuroscience, Karolinska Sjukhuset, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1111/1556-4029.12983DOI Listing
January 2016

Proteomics Reveals a Role for Attachment in Monocyte Differentiation into Efficient Proinflammatory Macrophages.

J Proteome Res 2015 Sep 11;14(9):3940-7. Epub 2015 Aug 11.

Centre for Molecular Medicine, Karolinska Hospital , SE 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.jproteome.5b00659DOI Listing
September 2015

Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice.

Eur J Med Res 2015 Mar 12;20:22. Epub 2015 Mar 12.

Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, 515041, China.

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http://www.eurjmedres.com/content/20/1/22
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http://dx.doi.org/10.1186/s40001-015-0114-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367909PMC
March 2015

Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of rapamycin signaling.

Reprod Sci 2015 Jan 6;22(1):60-7. Epub 2014 Jul 6.

Department of Gynaecology and Obstetrics of the First Affiliated Hospital, Shantou University Medical College, Shantou, China

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http://dx.doi.org/10.1177/1933719114542016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275449PMC
January 2015

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.

Cancer Res 2015 Jan 9;75(2):306-15. Epub 2014 Dec 9.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden. Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.

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http://cancerres.aacrjournals.org/content/early/2015/01/07/0
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http://cancerres.aacrjournals.org/content/early/2014/12/09/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-2819DOI Listing
January 2015

Clodronate liposomes reduce excessive scar formation in a mouse model of burn injury by reducing collagen deposition and TGF-β1 expression.

Mol Biol Rep 2014 19;41(4):2143-9. Epub 2014 Jan 19.

Cleft Lip and Palate Treatment Center, Second Affiliated Hospital, Medical College, Shantou University, Shantou, 515041, China.

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http://dx.doi.org/10.1007/s11033-014-3063-3DOI Listing
December 2014

Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.

Mol Pain 2014 Dec 10;10:78. Epub 2014 Dec 10.

Department of Clinical Neuroscience, Neuroimmunology Unit, CMM L8:05, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1744-8069-10-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271486PMC
December 2014

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling.

J Ovarian Res 2014 Oct 21;7:97. Epub 2014 Oct 21.

Laboratory of Cell Senescence, Shantou University Medical College, 22 Xin Ling Rd, Jinping District, Shantou, Guangdong Province, 515041, People's Republic of China.

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http://dx.doi.org/10.1186/s13048-014-0097-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232623PMC
October 2014

Obesity accelerates ovarian follicle development and follicle loss in rats.

Metabolism 2014 Jan 14;63(1):94-103. Epub 2013 Oct 14.

Laboratory of Cell Senescence, Shantou University Medical College, Xinling Road 22, Shantou 515041, P.R. China.

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http://dx.doi.org/10.1016/j.metabol.2013.09.001DOI Listing
January 2014

DNA aptamers that target human glioblastoma multiforme cells overexpressing epidermal growth factor receptor variant III in vitro.

Acta Pharmacol Sin 2013 Dec;34(12):1491-8

Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

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http://dx.doi.org/10.1038/aps.2013.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002567PMC
December 2013

[Effect of protein on the detection of antipsychotic drug residues in human serum and its elimination].

Guang Pu Xue Yu Guang Pu Fen Xi 2013 Sep;33(9):2492-5

School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China.

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September 2013

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression.

Gene 2013 Jul 6;523(1):82-7. Epub 2013 Apr 6.

Department of Gynaecology and Obstetrics of the First Affiliated Hospital, Medical College, Shantou University, Shantou 515041, China.

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http://dx.doi.org/10.1016/j.gene.2013.03.039DOI Listing
July 2013

Possible protecting role of TNF-α in kainic acid-induced neurotoxicity via down-regulation of NFκB signaling pathway.

Curr Alzheimer Res 2013 Jul;10(6):660-9

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.2174/15672050113109990007DOI Listing
July 2013

Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice.

Diabetes 2012 Nov 28;61(11):2881-92. Epub 2012 Jun 28.

Applied Immunology, Center for Molecular Medicine, Karolinska University Hospital at Solna, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db11-1635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478537PMC
November 2012

The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats.

Aging Clin Exp Res 2012 Apr 14;24(2):125-33. Epub 2011 Apr 14.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, PR China.

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http://dx.doi.org/10.3275/7660DOI Listing
April 2012

Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.

Exp Neurol 2012 Jan 4;233(1):323-32. Epub 2011 Nov 4.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.expneurol.2011.10.024DOI Listing
January 2012

APOE ε3 attenuates experimental autoimmune neuritis by modulating T cell, macrophage and Schwann cell functions.

Exp Neurol 2011 Aug 30;230(2):197-206. Epub 2011 Apr 30.

Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.expneurol.2011.04.016DOI Listing
August 2011

Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.

Curr Neuropharmacol 2011 Jun;9(2):388-98

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.2174/157015911795596540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131729PMC
June 2011

[Construction and identification of a RNA interference plasmid for rat BNIP3 gene].

Nan Fang Yi Ke Da Xue Xue Bao 2010 Nov;30(11):2432-5

Department of Neurobiology, College of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

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November 2010

γ-secretase inhibitor-I enhances radiosensitivity of glioblastoma cell lines by depleting CD133+ tumor cells.

Arch Med Res 2010 Oct;41(7):519-29

Department of Cell Biology, Guangdong Provincial Key Laboratory for Regenerative Medicine of Bone & Cartilage, Southern Medical University, No. 1023 Sha-tai Road, Guangzhou, Guangdong, P.R. China.

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http://linkinghub.elsevier.com/retrieve/pii/S018844091000301
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http://dx.doi.org/10.1016/j.arcmed.2010.10.006DOI Listing
October 2010

Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice.

J Neuroinflammation 2010 Apr 14;7:26. Epub 2010 Apr 14.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1742-2094-7-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865455PMC
April 2010

TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice.

J Neurosci Res 2008 May;86(7):1608-14

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/jnr.21600DOI Listing
May 2008

Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice.

Neurotoxicology 2008 May 8;29(3):406-12. Epub 2008 Feb 8.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuro.2008.01.006DOI Listing
May 2008

[Expression and identification of the extracellular domain of human epidermal growth factor receptor type III variant].

Nan Fang Yi Ke Da Xue Xue Bao 2008 Feb;28(2):151-3

Department of Neurobiology, Southern Medical University, Guangzhou 510515, China.

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February 2008

IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12.

Exp Neurol 2007 May 25;205(1):64-73. Epub 2007 Jan 25.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital in Huddinge, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S001448860700038
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http://dx.doi.org/10.1016/j.expneurol.2007.01.019DOI Listing
May 2007

IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.

J Neuroimmunol 2007 Feb 9;183(1-2):162-7. Epub 2007 Jan 9.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S016557280600508
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http://dx.doi.org/10.1016/j.jneuroim.2006.12.001DOI Listing
February 2007

[Screening of peptide inhibitors of acetylcholinesterase from 12-mer random phage display peptide library].

Nan Fang Yi Ke Da Xue Xue Bao 2006 Jul;26(7):1053-4

Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China.

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July 2006

Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice.

Brain Res 2005 Dec 9;1066(1-2):10-5. Epub 2005 Dec 9.

Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.brainres.2005.09.063DOI Listing
December 2005

Anti-epitope antibody, a novel site-directed antibody against human acetylcholinesterase.

Acta Pharmacol Sin 2004 Apr;25(4):431-5

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.

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April 2004

Specific oligobodies against human brain acetylcholinesterase.

Brain Res 2003 Nov;989(2):147-51

Beijing Institute of Pharmacology and Toxicology, Beijin 100850, China.

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http://dx.doi.org/10.1016/s0006-8993(03)03166-4DOI Listing
November 2003

Screening of RNA molecules inhibiting human acetylcholinesterase by virtue of systematic evolution of ligands by exponential enrichment.

Acta Pharmacol Sin 2003 Jul;24(7):711-4

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.

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July 2003

[Isolation, expression analysis of a chilling induced cDNA from rice root with differential display: an evidence role for caffeine-sensitive calcium signal].

Sheng Wu Gong Cheng Xue Bao 2002 Jul;18(4):468-71

Heilongjiang August First Reclamation Agriculture University, Mishan 158308, China.

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July 2002