Publications by authors named "Xing Huang"

405 Publications

Pan-Cancer Prognostic Role and Targeting Potential of the Estrogen-Progesterone Axis.

Front Oncol 2021 12;11:636365. Epub 2021 Jul 12.

Department of Pathology, Anhui Medical University, Hefei, China.

Introduction: Estrogen receptors (ESRs) and progesterone receptors (PGRs) are associated with the development and progression of various tumors. The feasibility of ESRs and PGRs as prognostic markers and therapeutic targets for multiple cancers was evaluated pan-cancer analysis.

Methods: The pan-cancer mRNA expression levels, genetic variations, and prognostic values of , , and were analyzed using the Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and cBioPortal. The expression levels of ERa, ERb, and PGR proteins were detected by immunohistochemical staining using paraffin-embedded tissue specimens of ovarian serous cystadenocarcinoma (OV) and uterine endometrioid adenocarcinoma (UTEA). Correlation between immunomodulators and immune cells was determined based on the Tumor and Immune System Interaction Database (TISIDB).

Results: , , and mRNAs were found to be differentially expressed in different cancer types, and were associated with tumor progression and clinical prognosis. ERa, ERb, and PGR proteins were further determined to be significantly differentially expressed in OV and UTEA immunohistochemical staining. The expression of ERa protein was positively correlated with a high tumor stage, whereas the expression of PGR protein was conversely associated with a high tumor stage in patients with OV. In patients with UTEA, the expression levels of both ERa and PGR proteins were conversely associated with tumor grade and stage. In addition, the expression levels of , , and mRNAs were significantly associated with the expression of immunomodulators and immune cells.

Conclusion: , , and are potential prognostic markers and therapeutic targets, as well as important factors for the prediction, evaluation, and individualized treatment in several cancer types.
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http://dx.doi.org/10.3389/fonc.2021.636365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311599PMC
July 2021

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.

Nat Commun 2021 07 27;12(1):4536. Epub 2021 Jul 27.

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we demonstrate that never in mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to maintain its stability, causing PD-L1-targeted pancreatic cancer immunotherapy to have poor efficacy. We identify NEK2 as a prognostic factor in immunologically "hot" pancreatic cancer, involved in the onset and development of pancreatic tumors in an immune-dependent manner. NEK2 deficiency results in the suppression of PD-L1 expression and enhancement of lymphocyte infiltration. A NEK binding motif (F/LXXS/T) is identified in the glycosylation-rich region of PD-L1. NEK2 interacts with PD-L1, phosphorylating the T194/T210 residues and preventing ubiquitin-proteasome pathway-mediated degradation of PD-L1 in ER lumen. NEK2 inhibition thereby sensitizes PD-L1 blockade, synergically enhancing the anti-pancreatic cancer immune response. Together, the present study proposes a promising strategy for improving the effectiveness of pancreatic cancer immunotherapy.
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http://dx.doi.org/10.1038/s41467-021-24769-3DOI Listing
July 2021

Pelvic round foreign matter after operation for necrotizing pancreatitis.

Surgery 2021 Jul 18. Epub 2021 Jul 18.

The First Department of General Surgery Department of Colorectal and Anal Surgery, Hunan Provincial People's Hospital, Hunan, Changsha, China. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2021.06.037DOI Listing
July 2021

Exploration of silicon functions to integrate with biotic stress tolerance and crop improvement.

Biol Res 2021 Jul 8;54(1):19. Epub 2021 Jul 8.

Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement (Guangxi), Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, 530007, Guangxi, China.

In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected by these stresses. After oxygen, silicon (Si) is the second most abundant element in the earth's crust. It is not considered as an important element, but can be thought of as a multi-beneficial quasi-essential element for plants. This review on silicon presents an overview of the versatile role of this element in a variety of plants. Plants absorb silicon through roots from the rhizospheric soil in the form of silicic or monosilicic acid. Silicon plays a key metabolic function in living organisms due to its relative abundance in the atmosphere. Plants with higher content of silicon in shoot or root are very few prone to attack by pests, and exhibit increased stress resistance. However, the more remarkable impact of silicon is the decrease in the number of seed intensities/soil-borne and foliar diseases of major plant varieties that are infected by biotrophic, hemi-biotrophic and necrotrophic pathogens. The amelioration in disease symptoms are due to the effect of silicon on a some factors involved in providing host resistance namely, duration of incubation, size, shape and number of lesions. The formation of a mechanical barrier beneath the cuticle and in the cell walls by the polymerization of silicon was first proposed as to how this element decreases plant disease severity. The current understanding of how this element enhances resistance in plants subjected to biotic stress, the exact functions and mechanisms by which it modulates plant biology by potentiating the host defence mechanism needs to be studied using genomics, metabolomics and proteomics. The role of silicon in helping the plants in adaption to biotic stress has been discussed which will help to plan in a systematic way the development of more sustainable agriculture for food security and safety in the future.
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http://dx.doi.org/10.1186/s40659-021-00344-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265040PMC
July 2021

Flavonoid scutellarin positively regulates root length through NUTCRACKER.

Plant Divers 2021 Jun 17;43(3):248-254. Epub 2020 Aug 17.

Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.

Exploring approaches to regulate meristem is of special importance and broad interest. In this study, we found that the flavonoid scutellarin, which has a 6-hydroxyl and a 7-glucoside, increased root length through the transcription factor NUTCRACKER (NUC). This root lengthening disappeared in -knockout and reappeared in -rescue plants. Scutellarin induced expression and promoted the division of cortex/endodermal initials. In contrast, naringenin, which has same chemical backbone but without 6-hydroxyl and with 7-hydroxyl group, showed the opposite or no effects. Our results demonstrate that scutellarin promotes root length through NUC-mediated regulatory pathways and reveal that flavonoids with and without the 6-hydroxyl and 7-glucoside have positive and negative effects on meristem size, respectively.
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http://dx.doi.org/10.1016/j.pld.2020.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233521PMC
June 2021

Magnetic field-aligned FeO-coated silver magnetoplasmonic nanochain with enhanced sensitivity for detection of Siglec-15.

Biosens Bioelectron 2021 Jun 17;191:113448. Epub 2021 Jun 17.

Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China; Shanghai Key Laboratory of Bio-Energy Crop, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address:

Noble metal nanoparticles could provide a significant gain in sensitivity of surface plasmon resonance (SPR) sensor by electromagnetic field coupling between the localized plasmon resonance of nanoparticles and gold film. A facile and cost-effective SPR sensor based on magnetic field-aligned FeO-coated silver magnetoplasmonic nanoparticles ([email protected]) nanochain ([email protected]) was proposed to improve the sensitivity of the sensor, which gave access to detect clinical targets at low concentration. Optimization experiments proved that 80 ng mL [email protected] SPR sensor showed high refractive index sensitivity and increased detection accuracy and quality factor when comparing with those of bare gold. Sialic acid binding Ig like lectins-15 (Siglec-15) was used as proof of concept to verify the sensitivity enhancement performance of [email protected] in the actual detection process. SPR angle shifts of [email protected]/gold sensor were significantly higher than those of traditional gold sensor under the same concentration of Siglec-15, which was consistent with previous performance analysis. Also, the detection limit of [email protected]/gold sensor was calculated to be 1.36 pg mL. All these results had proved that aligning [email protected] onto the gold chip could improve the performance of the SPR sensor and achieve sensitive detection of small amounts of clinical biomarkers.
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http://dx.doi.org/10.1016/j.bios.2021.113448DOI Listing
June 2021

A spin-1/2 gapped compound CdCu(SeO)Cl with a ladder structure.

Chem Commun (Camb) 2021 Jul;57(56):6923-6926

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, P. R. China.

The exploration of two-leg spin-ladder materials is a great challenge to the chemical community since it is one of the most ideal models for the study of low-dimensional magnetism and high-Tc superconductivity. Herein, we report on a successful synthesis of a new Cu2+-based two-leg ladder compound constructed by CuO4Cl2 octahedra along the [101] direction. The magnetic results exhibit a broad peak at Tmax ∼ 265 K, and suggest that CdCu2(SeO3)2Cl2 has a spin singlet ground state. The fitting of the isolated two-leg spin-ladder model shows J⊥/kB = 429 K and J‖/kB = 21 K, leading to a large spin gap of ∼409 K.
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http://dx.doi.org/10.1039/d1cc02243aDOI Listing
July 2021

Cancer environmental immunotherapy: starving tumor cell to death by targeting TGFB on immune cell.

J Immunother Cancer 2021 Jun;9(6)

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

The blockage of intersectional communication between tumor and its metabolic and immune microenvironment is now considered a promising solution in treating cancer. Tumors have been identified as a special type of "wounds" that do not heal. Recent studies demonstrate that the lack of the transforming growth factor beta (TGFB) signaling pathway in CD4 helper T cells induces the remodeling of the intratumoral vascular tissue, like healing "wounds" in damaged tissues caused by tumor overgrowth, which consequently prevents tumor cells from receiving the required nutrients in their microenvironment. TGFB blockade thereby promotes damaged tissue healing, causing tumor cell death as a result of starvation, ultimately obtaining an effective anticancer immunotherapy immune response. Here, we comment on the TGFB-mediated crosstalk between immune system and nutritional supply, highlighting cancer immunotherapeutic strategies targeting environmental immune-metabolism interplay. Cancer environmental immunotherapy targeting TGFB might therefore become one of the most promising treatment strategies for patients with cancer.
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http://dx.doi.org/10.1136/jitc-2021-002823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215255PMC
June 2021

Long non-coding RNA OIP5-AS1 inhibition upregulates microRNA-129-5p to repress resistance to temozolomide in glioblastoma cells via downregulating IGF2BP2.

Cell Biol Toxicol 2021 Jun 16. Epub 2021 Jun 16.

Department of Neurosurgery, Union Hospital of Tongji Medical College Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Jianghan District, Wuhan, 430022, Hubei, China.

Objective: Long non-coding RNAs (lncRNAs) and miRNAs (miRNAs) participate in tumors, while the effects of lncRNA OIP5 antisense RNA 1 (OIP5-AS1) and miR-129-5p on glioblastoma (GBM) remain to be further studied. We aim to explore the role of OIP5-AS1/miR-129-5p/insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) axis in GBM progression.

Methods: OIP5-AS1, miR-129-5p and IGF2BP2 expression in tissues was determined. Temozolomide (TMZ)-resistant GBM cells were established and transfected with relative plasmid to alter OIP5-AS1, IGF2BP2 or miR-129-5p expression. Then, the viability, proliferation, apoptosis and in vivo tumor growth were assessed. The subcellular localization of OIP5-AS1 was determined, and the binding relationships between OIP5-AS1 and miR-129-5p, and between miR-129-5p and IGF2BP2 were confirmed.

Results: OIP5-AS1 and IGF2BP2 were upregulated whereas miR-129-5p was downregulated in GBM. OIP5-AS1 silencing or miR-129-5p overexpression inhibited GBM cell chemoresistance to TMZ and proliferation, and promoted cell apoptosis. MiR-129-5p downregulation or IGF2BP2 upregulation reversed the role of OIP5-AS1 silencing on GBM cells. OIP5-AS1 sponged miR-129-5p and miR-129-5p targeted IGF2BP2.

Conclusion: OIP5-AS1 inhibition upregulated miR-129-5p to repress resistance to TMZ in GBM cells via downregulating IGF2BP2.
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http://dx.doi.org/10.1007/s10565-021-09614-zDOI Listing
June 2021

Ultrathin 2D Fe-Nanosheets Stabilized by 2D Mesoporous Silica: Synthesis and Application in Ammonia Synthesis.

ACS Appl Mater Interfaces 2021 Jun 15;13(25):30187-30197. Epub 2021 Jun 15.

Department of Heterogeneous Reactions, Max Planck Institute for Chemical Energy Conversion, 45470 Mülheim an der Ruhr, Germany.

Developing high-performance Fe-based ammonia catalysts through simple and cost-efficient methods has received an increased level of attention. Herein, we report for the first time, the synthesis of two-dimensional (2D) FeOOH nanoflakes encapsulated by mesoporous SiO (mSiO) via a simple solution-based method for ammonia synthesis. Due to the sticking of the mSiO coating layers and the limited spaces in between, the Fe after reduction retains the 2D morphology, showing high resistance against the sintering in the harsh Haber-Bosch process. Compared to supported Fe particles dispersed on mSiO spheres, the coated catalyst shows a significantly improved catalytic activity by 50% at 425 °C. Thermal desorption spectroscopy (TDS) reveals the existence of a higher density of reactive sites for N activation in the 2D Fe catalyst, which is possibly coupled to a larger density of surface defect sites (kinks, steps, point defects) that are generally considered as active centers in ammonia synthesis. Besides the structural impact of the coating on the 2D Fe, the electronic one is elucidated by partially substituting Si with Al in the coating, confirmed by Si and Al magic-angle spinning nuclear magnetic resonance (MAS NMR). An increased apparent activation energy () of the Al-containing catalyst evidences an influence on the nature of the active site. The herein-developed stable 2D Fe nanostructures can serve as an example of a 2D material applied in catalysis, offering the chance of a rational catalyst design based on a stepwise introduction of various promoters, in the coating and on the metal, maintaining the spatial control of the active centers.
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http://dx.doi.org/10.1021/acsami.1c06771DOI Listing
June 2021

The complete chloroplast genome of .

Mitochondrial DNA B Resour 2021 Jun 4;6(7):1855-1856. Epub 2021 Jun 4.

Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, PR China.

is one of the Agave cultivars for sisal fiber production around the tropical areas of the world. In the present study, we successfully sequenced and assembled its chloroplast genome. The full size of the genome is 157,268 bp with a GC content at 37.85%. The genome is constructed with a large single copy region (LSC, 85,894 bp), a pair of inverted repeat regions (IR, 26,573 bp) and a small single copy region (SSC, 18,228 bp). Besides, 86 protein-coding genes, 38 tRNAs and 8 rRNAs are annotated on the chloroplast genome. Phylogenetic result reveals that is closely related with and . H11648.
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http://dx.doi.org/10.1080/23802359.2021.1935345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183535PMC
June 2021

Phase Coexistence and Structural Dynamics of Redox Metal Catalysts Revealed by Operando TEM.

Adv Mater 2021 Jun 12:e2101772. Epub 2021 Jun 12.

Scientific Center for Optical and Electron Microscopy, ETH Zurich, Otto-Stern-Weg 3, Zurich, 8093, Switzerland.

Metal catalysts play an important role in industrial redox reactions. Although extensively studied, the state of these catalysts under operating conditions is largely unknown, and assignments of active sites remain speculative. Herein, an operando transmission electron microscopy study is presented, which interrelates the structural dynamics of redox metal catalysts to their activity. Using hydrogen oxidation on copper as an elementary redox reaction, it is revealed how the interaction between metal and the surrounding gas phase induces complex structural transformations and drives the system from a thermodynamic equilibrium toward a state controlled by the chemical dynamics. Direct imaging combined with the simultaneous detection of catalytic activity provides unparalleled structure-activity insights that identify distinct mechanisms for water formation and reveal the means by which the system self-adjusts to changes of the gas-phase chemical potential. Density functional theory calculations show that surface phase transitions are driven by chemical dynamics even when the system is far from a thermodynamic phase boundary. In a bottom-up approach, the dynamic behavior observed here for an elementary reaction is finally extended to more relevant redox reactions and other metal catalysts, which underlines the importance of chemical dynamics for the formation and constant re-generation of transient active sites during catalysis.
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http://dx.doi.org/10.1002/adma.202101772DOI Listing
June 2021

Editorial: Bioremediation of Chemical Pesticides Polluted Soil.

Front Microbiol 2021 21;12:682343. Epub 2021 May 21.

School of Environment and Energy, South China University of Technology, Guangzhou, China.

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http://dx.doi.org/10.3389/fmicb.2021.682343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175618PMC
May 2021

One dimensional magneto-optical nanocomplex from silver nanoclusters and magnetite nanorods containing ordered mesocages for sensitive detection of PD-L1.

Biosens Bioelectron 2021 Oct 31;189:113385. Epub 2021 May 31.

Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address:

Programmed death ligand 1 (PD-L1) is a typical immune checkpoint protein, whose up-regulation on the membrane of different tumor cells inhibits the immune response of T cells and leads to the escape of tumor cells. In this work, we designed a facile and highly specific surface plasmon resonance (SPR) biosensor to detect PD-L1 in human plasma based on magnetite nanorods containing ordered mesocages (MNOM) and silver nanoclusters (AgNCs). Magneto-optical nanocomplex [email protected] with superior magneto-optical properties and high signal-to-noise ratio were fabricated to improve the detection sensitivity owing to the high specific surface area of MNOM and excellent localized SPR of AgNCs. The PD-L1 Antibody on the surface of gold chip and the PD-L1 aptamer on [email protected] could realize dual selective recognition of PD-L1, providing the specificity of the sensor and reducing non-specific binding. The SPR sensor showed a good linear range of PD-L1 from 10 ng/mL to 300 ng/mL with the detection limit of 3.29 ng/mL. The practical performance of this immunosensing platform had been successfully verified by clinical samples which included healthy donors and cancer patients. Based on the analysis, the developed immunosensor provided a new strategy for point-of-care detection of PD-L1 and could be used as clinical companion diagnosis of PD-1/PD-L1 inhibitor therapy.
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http://dx.doi.org/10.1016/j.bios.2021.113385DOI Listing
October 2021

HAGP: A Heuristic Algorithm Based on Greedy Policy for Task Offloading with Reliability of MDs in MEC of the Industrial Internet.

Sensors (Basel) 2021 May 18;21(10). Epub 2021 May 18.

School of Computer Science & School of Software Engineering, Sichuan University, Chengdu 610065, China.

In the Industrial Internet, computing- and power-limited mobile devices (MDs) in the production process can hardly support the computation-intensive or time-sensitive applications. As a new computing paradigm, mobile edge computing (MEC) can almost meet the requirements of latency and calculation by handling tasks approximately close to MDs. However, the limited battery capacity of MDs causes unreliable task offloading in MEC, which will increase the system overhead and reduce the economic efficiency of manufacturing in actual production. To make the offloading scheme adaptive to that uncertain mobile environment, this paper considers the reliability of MDs, which is defined as residual energy after completing a computation task. In more detail, we first investigate the task offloading in MEC and also consider reliability as an important criterion. To optimize the system overhead caused by task offloading, we then construct the mathematical models for two different computing modes, namely, local computing and remote computing, and formulate task offloading as a mixed integer non-linear programming (MINLP) problem. To effectively solve the optimization problem, we further propose a heuristic algorithm based on greedy policy (HAGP). The algorithm achieves the optimal CPU cycle frequency for local computing and the optimal transmission power for remote computing by alternating optimization (AP) methods. It then makes the optimal offloading decision for each MD with a minimal system overhead in both of these two modes by the greedy policy under the limited wireless channels constraint. Finally, multiple experiments are simulated to verify the advantages of HAGP, and the results strongly confirm that the considered task offloading reliability of MDs can reduce the system overhead and further save energy consumption to prolong the life of the battery and support more computation tasks.
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http://dx.doi.org/10.3390/s21103513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157835PMC
May 2021

Platelet-driven coagulopathy in COVID-19 patients: in comparison to seasonal influenza cases.

Exp Hematol Oncol 2021 May 31;10(1):34. Epub 2021 May 31.

Jiangsu Province Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.

Background: One year into the coronavirus diseases 2019 (COVID-19) pandemic we analyzed the blood coagulopathy in severe and non-severe COVID-19 patients and linked to those of influenza patients for a comparative study.

Methods: We reported 461 COVID-19 patients and 409 seasonal influenza patients admitted at separated medical centers. With their demographic data and medical history, hematological profiles with coagulation characters were emphasized, and compared between two cohorts before and after treatment.

Results: For 870 patients included in this study, their median age was (64.0, 51.0-76.0), and among them 511 (58.7%) were male. Hypertension, diabetes, cardiovascular diseases, and bronchitis constituted the leading comorbidities. Upon hospital admission blood test results differentiated COVID-19 patients from influenza cases, and for COVID-19 patients, leukocytosis, neutrophilia, lymphocytopenia, and thrombocytopenia were associated with disease severity and mortality. In addition, COVID-19 cohort demonstrated a prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), increased INR, shortened thrombin time and decreased fibrinogen, compared to those in influenza cohort, leaving D-dimer levels indistinguishably high between both cohorts. Platelet hyperreactivity in COVID-19 is more evident, associated with worse hyper-inflammatory response and more refractory coagulopathy. For severe COVID-19 patients administered with anticoagulants, bleeding incidence was substantially higher than others with no anticoagulant medications.

Conclusions: Comparison of coagulation characteristics between COVID-19 and influenza infections provides an insightful view on SARS-CoV-2 pathogenesis and its coagulopathic mechanism, proposing for therapeutic improvement.
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http://dx.doi.org/10.1186/s40164-021-00228-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165133PMC
May 2021

Simultaneous denitrification and desulfurization-S recovery of wastewater in trickling filters by bioaugmentation intervention based on avoiding collapse critical points.

J Environ Manage 2021 Aug 25;292:112834. Epub 2021 May 25.

Key Laboratory of Carbohydrate Chemistry and Biotechnology (Jiangnan University) Ministry of Education. School of Biotechnology, Jiangnan University, Wuxi, 1800, Lihu Road, China; The Key Laboratory of Industrial Biotechnology, Ministry of Education, Wuxi, China. Electronic address:

In order to better achieve efficiently simultaneous desulfurization and denitrification/S recovery of wastewater, the intervention of sulfur oxidizing bacteria (SOB) and denitrifying bacteria (DNB) was employed to avoid the collapse critical points (the dramatically decrease of S/N removal efficiency) under the fluctuated load. With the assistance of DNB and SOB, collapse critical point of trickling filter (TF) was delayed from the P (105-114 d) to P stage (129-138 d). The treatment efficiency of nitrogen and sulfur was the highest with the S/N ratio of 3:1. The bioaugmentation of DNB and SOB at collapse critical point could effectively regulated collapse situation, which further increased the maximum system utilization/elimination capacity to 4.50 kg S m·h and 0.90 kg N m·h (increased by 56.89% and 65.56% in comparison to control). High-throughput sequencing analysis indicated that Proteobacteria (average 78.59%) and Bacteroidetes (average 9.30%) were dominant bacteria in the reactor at all stages. As the reaction proceeds, the microbial community was gradually dominated by some functional genera such as Chryseobacterium (average 2.97%), Halothiobacillus (average 22.71%), Rhodanobacter (average 14.02%), Thiobacillus (average 9.01%), Thiomonas (average 16.70%) and Metallibacterium (average 21.63%), which could remove nitrate or sulfide. Both of Principal Component Analysis (PCA) and Canonical Correlation Analysis (CCA) demonstrated the important role of DNB/SOB during the long-term run in the trickling filters (TFs).
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http://dx.doi.org/10.1016/j.jenvman.2021.112834DOI Listing
August 2021

Prognostic Nomogram for patients undergoing radical Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head.

BMC Cancer 2021 May 27;21(1):624. Epub 2021 May 27.

Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, China.

Background: Radical pancreaticoduodenectomy is the most common treatment strategy for patients diagnosed with adenocarcinoma of the pancreatic head. Few studies have reported the clinical characteristics and treatment efficacies of patients undergoing radical pancreaticoduodenectomy for adenocarcinoma of the pancreatic head.

Methods: A total of 177 pancreatic head cancer patients who underwent radical pancreaticoduodenectomy and were pathologically confirmed as having pancreatic ductal adenocarcinoma were screened in the West China Hospital of Sichuan University. The multivariate analysis results were implemented to construct a nomogram. The concordance index (c-index), the area under the curve (AUC) and calibration were utilized to evaluate the predictive performance of the nomogram.

Results: The prognostic nutritional index (PNI), the lymph node ratio (LNR) and the American Joint Committee on Cancer (AJCC) staging served as independent prognostic factors and were used to construct the nomogram. The c-indexes of the nomogram were 0.799 (confidence interval (CI), 0.741-0.858) and 0.732 (0.657-0.807) in the primary set and validation set, respectively. The AUCs of the nomogram at 1 and 3 years were 0.832 and 0.783, which were superior to the AJCC staging values of 0.759 and 0.705, respectively.

Conclusions: The nomogram may be used to predict the prognosis of radical resection for adenocarcinoma of the pancreatic head. These findings may represent an effective model for the developing an optimal therapeutic schedule for malnourished patients who need early effective nutritional intervention and may promote the treatment efficacy of resectable adenocarcinoma of the pancreatic head.
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http://dx.doi.org/10.1186/s12885-021-08295-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161963PMC
May 2021

Surface-Modified Phthalocyanine-Based Two-Dimensional Conjugated Metal-Organic Framework Films for Polarity-Selective Chemiresistive Sensing.

Angew Chem Int Ed Engl 2021 May 25. Epub 2021 May 25.

Center for Advancing Electronics Dresden (cfaed) and Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, 01062, Dresden, Germany.

2D conjugated metal-organic frameworks (2D c-MOFs) are emerging as electroactive materials for chemiresistive sensors, but selective sensing with fast response/recovery is a challenge. Phthalocyanine-based Ni [MPc(NH) ] 2D c-MOF films are presented as active layers for polarity-selective chemiresisitors toward water and volatile organic compounds (VOCs). Surface-hydrophobic modification by grafting aliphatic alkyl chains on 2D c-MOF films decreases diffused analytes into the MOF backbone, resulting in a considerably accelerated recovery progress (from ca. 50 to ca. 10 s) during humidity sensing. Toward VOCs, the sensors deliver a polarity-selective response among alcohols but no signal for low-polarity aprotic hydrocarbons. The octadecyltrimethoxysilane-modified Ni [MPc(NH) ] based sensor displays high-performance methanol sensing with fast response (36 s)/recovery (13 s) and a detection limit as low as 10 ppm, surpassing reported room-temperature chemiresistors.
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http://dx.doi.org/10.1002/anie.202104461DOI Listing
May 2021

Pancreatic tumor initiation: the potential role of IL-33.

Signal Transduct Target Ther 2021 May 22;6(1):204. Epub 2021 May 22.

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1038/s41392-021-00636-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141049PMC
May 2021

Corrigendum to "Polar auxin transport May Be responsive to specific features of flavonoid structure" [Phytochemistry 185 (2021) 112702].

Phytochemistry 2021 Aug 18;188:112801. Epub 2021 May 18.

Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2021.112801DOI Listing
August 2021

Hierarchical [email protected]/Co-MOF core-shell nanoflower derived from copper/cobalt bimetallic metal-organic frameworks for supercapacitors.

J Colloid Interface Sci 2021 Oct 6;600:72-82. Epub 2021 May 6.

School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Haiquan Road 100, 201418 Shanghai, PR China; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Long Teng Road 333, 201620 Shanghai, PR China. Electronic address:

Rational design of composite materials with unique core-shell nanoflower structures is an important strategy for improving the electrochemical properties of supercapacitors such as capacitance and cycle stability. Herein, a two-step electrodeposition technique is used to orderly synthesize CuCoO and CoS on Ni foam coated with Cu/Co bimetal metal organic framework (Cu/Co-MOF) to fabricate a hierarchical core-shell nanoflower material ([email protected]/Co-MOF). This unique structure can increase the electrochemically active site of the composite, promoting the Faradaic redox reaction and enhancing its electrochemical properties. [email protected]/Co-MOF shows a prominent specific capacitance of 3150 F g at 1 A g, marvelous rate performance of 81.82% (2577.3 F g at 30 A g) and long cycle life (maintaining 96.74% after 10,000 cycles). What is more, the assembled [email protected]/Co-MOF//CNTs device has an energy density of 73.19 Wh kg when the power density is 849.94 W kg. It has unexpected application prospects.
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http://dx.doi.org/10.1016/j.jcis.2021.05.008DOI Listing
October 2021

Response relationships between abrupt seasonal temperature changes/warming (cooling) hiatuses in China and their influencing factors.

Environ Sci Pollut Res Int 2021 May 14. Epub 2021 May 14.

College of Water Conservancy and Civil Engineering College, Inner Mongolia Agricultural University, Hohhot, 010018, China.

The mechanisms of abrupt seasonal temperature changes and warming (cooling) hiatuses remain unclear. Clarifying how they respond to various influencing factors is critically important to understanding their mechanisms. In this study, the influencing factors to which the abrupt changes in T, T, and T were most sensitive followed the order of (AGG and CO) > SR > WS > AMO > PDO > MEI > AO > AP > RH. Seasonal Tav had the greatest sensitivity to all influencing factors, followed by seasonal Tav and lastly by seasonal T. An abrupt temperature change occurred when AGG, AMO, or SR increased continuously to a certain value, when PDO was in a positive phase (warm phase) and increased continuously to a certain value, when MEI changed abruptly, when WS and RH continued to decline for a certain time and reached a certain tendency rate, or when AP continued to decline for a certain time and reached a certain value. During the period before and after the warming (cooling) hiatuses, the temperature at most of the stations only had a significant relationship with a few influencing factors, and the hiatuses in seasonal T, T, and T were overall most sensitive to changes in WS, followed by changes in RH and lastly by changes in AP. The occurrence of warming (cooling) hiatuses was highly consistent with the variation trend of some influencing factors, which to some extent affected the warming (cooling) hiatuses. Abrupt seasonal temperature changes/warming (cooling) hiatuses are the combined effects of multiple influencing factors.
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http://dx.doi.org/10.1007/s11356-021-14190-0DOI Listing
May 2021

Ultra-narrowband near-infrared tunable two-dimensional perfect absorber for refractive index sensing.

Appl Opt 2021 May;60(14):4113-4119

An ultra-narrow-bandwidth near-infrared perfect plasmonic absorber with a periodic structure composed of metal-insulator-metal configuration is numerically designed and analyzed for a refractive index sensor. A perfect absorptivity of 99.99% and a rather narrow bandwidth of 2 nm are observed in the near-infrared wave band when the light is vertically incident in the structure. The ultra-high absorption and ultra-narrow bandwidth are explained as local surface plasmon resonance stimulated in the structure. The absorber is put into use as a plasmonic refractive index sensor with wavelength sensitivity as high as 1500 nm/RIU and figure of merit as high as 750, which significantly surpass those of many plasmonic sensors proposed in the past few decades. The designed absorber is tunable by changing geometry parameters. Because of the excellent sensing properties mentioned above, the proposed structure can be widely applied in fields such as photodetectors, biosensors, and chemical molecule detection.
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http://dx.doi.org/10.1364/AO.424471DOI Listing
May 2021

[Screening of key genes and pathways of ischemic stroke and prediction of traditional Chinese medicines based on bioinformatics].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1803-1812

Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China Institute for Brain Disorders, Beijing University of Chinese Medicine Bejing 100700, China.

The aim of this paper was to explore the key genes and pathogenesis of ischemic stroke(IS) by bioinformatics, and predict the potential traditional Chinese medicines for IS. Based on the gene-chip raw data set of GSE22255 from National Center of Biotechnology Information(NCBI), the article enrolled in 20 patients with ischemic stroke and 20 sex-and age-matched controls, and differentially expressed genes(DEGs) were screened based on R language software. The DAVID tool and R language software were used to perform gene ontology(GO) biological process enrichment analysis and Kyoto encyclopedia of genes and gnomes(KEGG) pathway enrichment analysis. The DEGs were imported into STRING to construct a protein-protein interaction network, and the Molecular Complexity Module(MCODE) plug-in of Cytoscape software was used to visualize and analyze the key functional modules. Moreover, the core genes and the medical ontology information retrieval platform(Coremine Medical) were mapped to each other to screen the traditional Chinese medicines and construct drug-active ingredient-target network. Compared with healthy controls, 14 DEGs were obtained, of which 12 genes were up-regulated and 2 genes were down-regulated. DEGs were mainly involved in immune response, inflammatory process, signal transduction, and cell proliferation regulation. The interleukin-17(IL-17), nuclear factor kappaB(NF-κB), tumor necrosis factor(TNF), nucleotide binding oligomerization domain(NOD)-like receptor and other signaling pathways were involved in KEGG pathway enrichment analysis. The key modules of the DEGs-encoding protein interaction network mainly focused on 7 genes of TNF, JUN, recombinant immediate early response 3(IER3), recombinant early growth response protein 1(EGR1), prostaglandin-endoperoxide synthase 2(PTGS2), C-X-C motif chemokine ligand 8(CXCL8) and C-X-C motif chemokine ligand 2(CXCL2), which were involved in biological processes widely such as neuroinflammation and immunity. TNF and JUN were the key nodes in this module, which might become potential biological markers for diagnosis and prognosis evaluation of IS. The potential traditional Chinese medicines for the treatment of IS includes Salviae Miltiorrhizae Radix et Rhizoma, Croci Stigma, Scutellariae Radix, and Cannabis Fructus. The occurrence of stroke was the result of multiple factors. Dysregulation of genes and pathways related to immune regulation and inflammation may be the key link for the development of IS. This study provided research direction and theoretical basis for further exploring the mechanism of action of traditional Chinese medicine in the treatment of IS and searching for potential drug targets.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20210218.401DOI Listing
April 2021

First Report of Paramyrothecium breviseta Causing Leaf Spot Disease of Coffea canephora in China.

Plant Dis 2021 May 11. Epub 2021 May 11.

Hai Kou , China;

Coffee is a tropical plant with two widely cultivated species, namely Coffea arabica and Coffea canephora. A leaf spot disease causing brownish and necrotic lesions was broken out on the C. canephora coffee seedlings in a nursery in Ruili County, Yunnan Province, China, during 2018 to 2019. The incidence of the disease was 15% ~ 20%. Ten diseased leaf samples from five diseased plants were collected for pathogen isolation by tissue separation method. Leaf pieces were cut from the margin of the necrotic lesions (4 × 6 mm), surface-sterilized for 30 s in 75% ethanol, followed by 0.1% arsenic mercury solution for 15 s, then washed 3~4 times with sterilized distilled water and transferred onto potato dextrose agar (PDA) medium in petri plates. Four morphologically similar isolates were obtained from lesions and cultivated on PDA at 25°C. Initial colonies of isolates were round, neat edge, white, floccose mycelium and developed dark green-to-black concentric rings that were sporodochia bearing viscid spore masses after 5~7 days. Conidia were acetates, hyaline and cylindrical with both rounded ends and 4.8 to 6.4 µm long × 1.6 to 2.6 µm wide. Koch's test were conducted on three healthy plants leaves of original source variety C. canephora No.2 and C.arabica Catimor CIFC7963 (control plants) with spore suspension (1 × 106/mL), respectively. Meanwhile, equal numbers of healthy plants were inoculated with water as controls. After inoculation, the plants were transferred into an incubator at 25℃ with saturated humidity. After 10 days of inoculation, all the tested plants presented similar typical symptoms with the diseased leaves under natural conditions; whereas the controls remained healthy. Koch's postulates were performed by re-isolating the fungus from the inoculated leaves and verifying its colony and morphological characters. Two single spore isolates cultured on PDA medium were selected for DNA extraction. The ribosomal internal transcribed spacer (ITS) was PCR amplified by using primers ITS1 and ITS4 (White et al., 1990), β-tubulin gene by Bt2a and Bt2b (Glass and Donaldson, 1995), the RNA polymerase II second largest subunit (rpb2) by RPB2-5F2 and RPB2-7cR (O'Donnell et al, 2007), calmodulin (cmda) gene by CAL-228F and CAL2Rd (Groenewald et al., 2013). The sequences of ITS (MT853067 ~ MT853068), β-tubulin (MT897899 ~ MT897900), rpb2 (MW256264~ MW286265) and cmda (MT897897~ MT897898) were deposited in GenBank databases. BLAST analysis revealed that the representative isolates sequences shared 99.31%~99.65% similarities to the ITS sequence of Paramyrothecium breviseta (Accession Nos. NR_155670.1), 99.43% similarities to the β-tubulin sequence of P. breviseta (Accession Nos. KU846406.1), 98.98% similarities to the rpb2 sequence of P. breviseta (Accession Nos. KU846351.1), and 98.54%~98.71% similarities to the cmda sequence of P. breviseta (Accession Nos. KU846262.1). As it shown in the phylogenetic tree derived from combined ITS, β-tubulin, rpb2, and cmda gene sequences, the two representative isolates were clustered together with P. breviseta CBS 544.75 with 98% strong bootstrap support, which confirmed that P. breviseta is the causal agent of leaf spot of Coffea canephora. To our knowledge, this is the first report of a leaf spot disease caused by P. breviseta on C. canephora in China, which raised the caution that P. breviseta is also pathogenic to Coffea Arabica.
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http://dx.doi.org/10.1094/PDIS-10-20-2276-PDNDOI Listing
May 2021

Efficient inverse design and spectrum prediction for nanophotonic devices based on deep recurrent neural networks.

Nanotechnology 2021 May 24;32(33). Epub 2021 May 24.

Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.

The development of nanophotonic devices has presented a revolutionary means to manipulate light at nanoscale. How to efficiently design these devices is an active area of research. Recently, artificial neural networks (ANNs) have displayed powerful ability in the inverse design of nanophotonic devices. However, there is limited research on the inverse design for modeling and learning the sequence characteristics of a spectrum. In this work, we propose a deep learning method based on an improved recurrent neural network to extract the sequence characteristics of a spectrum and achieve inverse design and spectrum prediction. A key feature of the network is that the memory or feedback loops it comprises allow it to effectively recognize time series data. In the context of nanorods hyperbolic metamaterials, we demonstrated the high consistency between the target spectrum and the predicted spectrum, and the network learned the deep physical relationship concerning the structural parameter changes reflected on the spectrum. The effectiveness of our approach is also tested by user-drawn spectra. Moreover, the proposed model is capable of predicting an unknown spectrum based on a known spectrum with only 0.32% mean relative error. The prediction model may be helpful to predict data beyond the detection limit. We propose this versatile method as an effective and accurate alternative to the application of ANNs in nanophotonics, paving way for fast and accurate design of desired devices.
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http://dx.doi.org/10.1088/1361-6528/abff8dDOI Listing
May 2021

The Poor Prognosis of Patients with Stage III Gastric Cancer after D2 Dissection Is Mainly due to Lymphatic Metastasis, Especially the Metastasis of No.12a LN: A Nested Case-Control Study.

Oncol Res Treat 2021 4;44(6):313-321. Epub 2021 May 4.

Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The prognosis of stage III gastric cancer (GC) patients based on the 8th edition TNM staging system after D2 dissection was still heterogeneous. We aimed to explore clinicopathological reasons that led to the poor prognosis of these patients, especially from a surgical aspect.

Methods: We divided 320 stage III GC patients who underwent distal or total gastrectomy with D2 lymphadenectomy into group 1 and group 2, according to the disease-free survival (DFS), and compared the clinicopathological features between these 2 groups. Then, we divided group 1 into group 1D and group 1T and group 2 into group 2D and group 2T, according to distal or total gastrectomy. Finally, we compared the status of lymph node (LN) metastasis in each group of perigastric LN between the subgroups, respectively.

Results: Univariate analyses revealed that patients' LN metastasis was the only significant difference between group 1 and group 2 (p < 0.05). Compared with group 1D, the percentage of patients who had metastatic LN in all groups of the perigastric LN (included No.1, 3, 4sb, 4d, 5, 6, 7, 8a, 9, 11p and 12a) increased in group 2D. A similar tendency was found in group 2T (included No.1, 2, 3, 4sa, 4sb, 4d, 5, 6, 7, 8a, 9, 10, 11p, 11d and 12a) compared with group 1T. Further multivariate regression analyses revealed that the increases of group No.12a and 5 LN were significant (p < 0.05) in group 2D, the increases of group No.12a, 8a and 6 LN were significant (p < 0.05) in group 2T, respectively. Among these, the increases of group No.12a LNs were the most significant (p < 0.01).

Conclusions: The poor prognosis of patients with stage III GC after D2 dissection is mainly due to lymphatic metastasis. The status of LN metastasis in the prognostic value of GC needs to be further enhanced in present staging systems. Maybe the metastasis of No.12a LN is the most significant poor prognostic factor of these patients. It points out that the dissection of No.12a LN should be carefully performed in radical gastrectomy.
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http://dx.doi.org/10.1159/000512934DOI Listing
May 2021

C1orf61 promotes hepatocellular carcinoma metastasis and increases the therapeutic response to sorafenib.

Biochim Biophys Acta Mol Cell Res 2021 Jul 27;1868(8):119048. Epub 2021 Apr 27.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, PR China. Electronic address:

C1orf61 is a specific transcriptional activator that is highly up-regulated during weeks 4-9 of human embryogenesis, the period in which most organs develop. We have previously demonstrated that C1orf61 acts as a tumor activator in human hepatocellular carcinoma (HCC) tumorigenesis and metastasis. However, the underlying molecular mechanisms of tumor initiation and progression in HCC remain obscure. In this study, we demonstrated that the pattern of C1orf61 expression was closely correlated with metastasis in liver cancer cells. Gene expression profiling analysis indicated that C1orf61 regulated diverse genes related to cell growth, migration, invasion and epithelial-mesenchymal transition (EMT). Results showed that C1orf61 promotes hepatocellular carcinoma metastasis by inducing cellular EMT in vivo and in vitro. Moreover, C1orf61-induced cellular EMT and migration are involved in the activation of the STAT3 and Akt cascade pathways. In addition, C1orf61 expression improved the efficacy of the anticancer therapy sorafenib in HCC patients. For the first time, we report a regulatory pathway by which C1orf61 promoted cancer cell metastasis and regulated the therapeutic response to sorafenib. These findings increased our understanding of the molecular events that regulate metastasis and treatment in HCC.
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http://dx.doi.org/10.1016/j.bbamcr.2021.119048DOI Listing
July 2021

Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis.

Cancer Cell Int 2021 Apr 15;21(1):217. Epub 2021 Apr 15.

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

Background: Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong patient survival. Alkaline phosphatase (ALPL), a homodimeric cell surface phosphohydrolase, is reported to play a controversial role in prostate cancer and ovarian cancer cell migration; however, the function of ALPL in LUAD and the related mechanisms remain unclear.

Methods: TCGA database was used to analysis the expression of ALPL, and further verification was performed in a cohort of 36 LUAD samples by qPCR and western blot. Soft-agar assay, transwell assay and lung metastasis assay were employed to detect the function of ALPL in LUAD progression. The qPCR, luciferase promoter reporter assay and western blot were used to clarify the molecular mechanisms of ALPL in promoting metastasis in LUAD.

Results: ALPL was downregulated in LUAD, and the disease-free survival rate of patients with low ALPL was significantly reduced. Further studies showed that overexpression of ALPL in LUAD cell lines did not significantly affect cell proliferation, but it did significantly attenuate lung metastasis in a mouse model. ALPL downregulation in LUAD led to a decrease in the amount of phosphorylated (p)-ERK. Because p-ERK promotes the classical c-Myc degradation pathway, the decrease in p-ERK led to the accumulation of c-Myc and therefore to an increase in RhoA transcription, which enhanced LUAD cell metastasis.

Conclusion: ALPL specially inhibits the metastasis of LUAD cells by affecting the p-ERK/c-Myc/RhoA axis, providing a theoretical basis for the targeted therapy of clinical LUAD.
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http://dx.doi.org/10.1186/s12935-021-01919-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050923PMC
April 2021
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