Publications by authors named "Xing Feng"

324 Publications

Pd-Immobilized Schiff Base Double-Layer Macrocycle: Synthesis, Structures, Peroxidase Mimic Activity, and Antibacterial Performance.

ACS Appl Mater Interfaces 2022 Jan 30;14(1):1423-1433. Epub 2021 Dec 30.

Department of Chemistry, University of Hull, Hull HU6 7RX, U.K.

Di-, tri-, and tetra-aldehydes have been employed to access new [2 + 2] [2 + 3] and [2 + 4] double-layer Schiff base macrocycles. The [2 + 3] compound has been used for the immobilization of Pd and the resulting composite has been employed as a peroxidase-like mimetic using 3,3',5,5'-tetramethylbenzidine (TMB) as the substrate; the optimum conditions together with the catalytic kinetics of the enzyme-like activity is discussed. Based on the peroxidase-like catalytic activity, the [email protected] base composite was found to exhibit excellent bactericidal activity against both (Gram-negative bacterium) and (Gram-positive bacterium) in the presence of relatively low concentrations of HO. Furthermore, cytotoxicity measurements illustrate the biosafety of the Pd composite. The above-mentioned findings have the potential to guide the innovation of new Pd-based composites as enzyme mimetics and antibacterial materials.
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http://dx.doi.org/10.1021/acsami.1c19795DOI Listing
January 2022

"Indanonalkene" Photoluminescence Platform: Application in Real-Time Tracking the Synthesis, Remodeling, and Degradation of Soft Materials.

J Am Chem Soc 2021 Dec 14;143(51):21622-21629. Epub 2021 Dec 14.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

In this Article, we present a strategy to visually track chemically triggered covalent bonding processes in gelation, remodeling, and degradation of soft materials, i.e., hydrogels, based on a new photoluminescence platform. Initially in the development of photoluminophors named "indanonalkenes", turn-on emission can be tracked and quantified in the optical reaction between a conjugate acceptor and amine derivatives. On this basis, fluorescence enhancement and mechanical changes were recorded during the gelation process through amine-thiol exchanges under organic and aqueous conditions. Next in macromolecular remodeling, we realized a stimulus-induced transformation of one architecture into another one, exploiting the orthogonality of chemical covalent bonding that could be visualized using luminescence. Furthermore, the hydrogel network can be degraded to release the coupling partner induced by ethylene diamine, and the process can be monitored using fluorescence changes and quantified through gel permeation chromatography, while the released components can be utilized again to regenerate a new hydrogel. In addition, the photographic images provide alternatives to fluorescence spectra and can be digitally processed to quantify the macroscopic changes, resulting in a photographic imaging approach. The real-time observation and quantification of chemically triggered polymeric formation, morphology, and degradation through luminescence in spatial and time scales herald a new generation of "smart" materials.
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http://dx.doi.org/10.1021/jacs.1c09895DOI Listing
December 2021

2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2021 Dec 7. Epub 2021 Dec 7.

Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, China.

Background & Aims: The increasing rates of obesity and type 2 diabetes mellitus may lead to increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine the current and recent trends on the global and regional prevalence of NAFLD.

Methods: Systematic search from inception to March 26, 2020 was performed without language restrictions. Two authors independently performed screening and data extraction. We performed meta-regression to determine trends in NAFLD prevalence.

Results: We identified 17,244 articles from literature search and included 245 eligible studies involving 5,399,254 individuals. The pooled global prevalence of NAFLD was 29.8% (95% confidence interval [CI], 28.6%-31.1%); of these, 82.5% of included articles used ultrasound to diagnose NAFLD, with prevalence of 30.6% (95% CI, 29.2%-32.0%). South America (3 studies, 5716 individuals) and North America (4 studies, 18,236 individuals) had the highest NAFLD prevalence at 35.7% (95% CI, 34.0%-37.5%) and 35.3% (95% CI, 25.4%-45.9%), respectively. From 1991 to 2019, trend analysis showed NAFLD increased from 21.9% to 37.3% (yearly increase of 0.7%, P < .0001), with South America showing the most rapid change of 2.7% per year, followed by Europe at 1.1%.

Conclusions: Despite regional variation, the global prevalence of NAFLD is increasing overall. Policy makers must work toward reversing the current trends by increasing awareness of NAFLD and promoting healthy lifestyle environments.
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http://dx.doi.org/10.1016/j.cgh.2021.12.002DOI Listing
December 2021

Factors affecting the frequency and contents of routine antenatal care in remote rural China in 2009-2016: An observational study.

BJOG 2021 Dec 3. Epub 2021 Dec 3.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Objective: We assessed factors associated with the frequency and contents of antenatal care (ANC) in remote rural China, including the province of residence and individual-level factors.

Design: Survey-based cross-sectional study.

Setting: Five provinces in remote rural China: Guizhou, Hunan, Jilin, Ningxia and Shaanxi.

Sample: A cohort of 3918 women with a live birth in 2009-2016.

Methods: Poisson regression.

Main Outcome Measures: ANC frequency: five or more visits, starting in the first trimester. ANC contents: coverage of six care components and overuse of ultrasound.

Results: Three-quarters (72.9%) of women had five or more ANC visits, starting in the first trimester; 68.8% received all six care components and 94.5% had three or more ultrasounds. Only 30.9% of women sought ANC from township hospitals, paying between $3.80 and $25.80 per visit. ANC frequency and contents were associated with the socio-economic characteristics of the women, but provincial effects were much greater, even after adjusting for individual factors. Women living in Guizhou and Ningxia, the two poorest provinces, with high proportions of ethnic minorities, were particularly underserved. Compared with women in Shaanxi, women in Guizhou were 33% (adjusted RR 0.67, 95% CI 0.61-0.74) less likely to receive five or more ANC visits, starting in the first trimester; women in Ningxia were 17% less likely (adjusted RR 0.83, 95% CI 0.76-0.90) to receive all six care components.

Conclusions: The province of residence was a stronger predictor of ANC frequency and contents than the individual characteristics of women in China, suggesting that strengthening the decentralised system of the financing and organisation of ANC at the province level is crucial for achieving success. Future efforts are warranted to engage subregional administrations.
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http://dx.doi.org/10.1111/1471-0528.17037DOI Listing
December 2021

Enhanced luminescence performances of BaLaMgTaO:Mn red phosphor by Bi, Ca doping for indoor plant lighting supplementary LED.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Mar 24;268:120655. Epub 2021 Nov 24.

College of Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.

A new perovskite BaLaMgTaO:Mn (BLMTO:Mn) red phosphor was synthesized for the first time via the high-temperature solid-state method. The emission band of the phosphor ranges from 650 to 750 nm, which matches well with the absorption band of P and P. By doping of Bi and Ca ions in the BLMTO:Mn phosphor, a 4.76-fold enhancement in the luminescence emission intensity was achieved. The optimized BLMTO:0.5%Mn, 1.5%Bi, 2%Ca phosphor exhibited a high quantum efficiency of 65% and a high color purity of 98.1% with the chromaticity coordinate (CIE) at (0.733, 0.267). Finally, a LED device was fabricated with the BLMTO:0.5%Mn, 1.5%Bi, 2%Ca phosphor for further agricultural lighting, which emits warm white light with a low color temperature of 3549 K. The result indicates that the BLMTO:Mn, Bi, Ca phosphors have a potential for applications in agricultural cultivations.
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http://dx.doi.org/10.1016/j.saa.2021.120655DOI Listing
March 2022

Efficacy of canagliflozin versus metformin in women with polycystic ovary syndrome: A randomized, open-label, noninferiority trial.

Diabetes Obes Metab 2022 Feb 25;24(2):312-320. Epub 2021 Nov 25.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: To determine the safety and efficacy of canagliflozin in comparison to metformin in polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).

Methods: A single-centre, prospective, randomized open-label (ratio 1:1) noninferiority trial was conducted at the Department of Endocrinology, Shanghai Tenth People's Hospital, between July 2019 and April 2021. Women aged 18 to 45 years with PCOS and IR were enrolled and randomly assigned to either 100 mg (n = 33) canagliflozin daily or 1500 to 2000 mg metformin daily (n = 35) for 12 weeks. The primary outcome was changes in homeostatic model assessment (HOMA)-IR after 12 weeks of treatment. The secondary outcomes included changes in anthropometric measurements, menstrual frequency, sex hormone levels, metabolic variables and body fat distribution.

Results: For lowering of HOMA-IR after 12 weeks of treatment, canagliflozin was found to be noninferior to metformin (least-squares mean difference -0.81% [95% confidence interval -2.13 to 0.51]). Both canagliflozin and metformin significantly improved menstrual pattern, reduced body weight and total fat mass, and decreased triglyceride levels. Compared with metformin, canagliflozin had significant advantages in reducing uric acid and dehydroepiandrosterone sulphate levels. Pruritus vulvae (9.09%) and gastrointestinal reaction (55.55%) were the main adverse events in the metformin group and canagliflozin group, respectively.

Conclusion: This study demonstrates that canagliflozin was not inferior to metformin in PCOS patients with IR, which suggests that sodium-glucose cotransporter-2 inhibitors should be considered as effective drugs in the treatment of PCOS patients with IR.
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http://dx.doi.org/10.1111/dom.14583DOI Listing
February 2022

Stimuli-Responsive Materials from Ferrocene-Based Organic Small Molecule for Wearable Sensors.

Small 2021 11 5;17(46):e2103125. Epub 2021 Oct 5.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Stimuli-responsive crystals capable of energy conversion have emerged as promising materials for smart sensors, actuators, wearable devices, and robotics. Here, a novel ferrocene-based organic molecule crystal (Fc-Cz) that possesses anisotropic piezoelectric, optical, and mechanical properties is reported. It is demonstrated that the new crystal Fc-Cz can be used as an ultrasensitive piezoelectric material in fabricating strain sensors. The flexible sensor made of crystal Fc-Cz can detect small strains/deformations and motions with a fast response speed. Analysis based on density functional theory (DFT) indicates that an external pressure can affect the dipole moment by changing the molecular configuration of the asymmetric single crystal Fc-Cz in the crystalline state, leading to a change of polarity, and thereby an enhanced dielectric constant. This work demonstrates a new artificial organic small molecule for high-performance tactile sensors, indicating its great potential for developing low-cost flexible wearable sensors.
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http://dx.doi.org/10.1002/smll.202103125DOI Listing
November 2021

Short-Term Ambient Particulate Air Pollution and Hospitalization Expenditures of Cause-Specific Cardiorespiratory Diseases in China: A Multicity Analysis.

Lancet Reg Health West Pac 2021 Oct 31;15:100232. Epub 2021 Jul 31.

Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Background: Ambient air pollution is leading risk factor for health burden in China. Few studies in China have investigated the economic loss related to short-term exposure to ambient PM, which could trigger acute onset of cardiorespiratory diseases within a few days.

Methods: Daily ambient air pollutants data are obtained for each city from the National Air Quality Monitoring System and daily hospitalization data are obtained from the urban employee-based basic medical insurance scheme database in 74 Chinese cities with an average coverage of 88.5 million urban employees during 2016-2017. A three-stage time-series analytic approach is used in this study to investigate the impact of short-term exposure to ambient fine particulate (PM) air pollution on hospital admissions, expenses and hospital stays of three cause-specific cardiorespiratory diseases, including lower respiratory infections (LRI), coronary heart disease (CHD) and stroke in the included cities.

Findings: Based on the time-series analysis using daily hospitalization data, 28,560 LRI cases, 54,600 CHD cases, and 23,989 stroke cases are attributable to ambient PM in the 74 cities during the study period, and the related attributable expenses are 220 million CNY (US$ 32.9 million) for LRI, 458 million CNY (US$ 68.5 million) for CHD, and 410 million CNY (US$ 65.8 million) for stroke, respectively. These attributable numbers account for 1.45% to 2.05% of total hospital admissions and 1.10% to 1.51% of total expenses for the three diseases during 2016-2017, respectively. The attributable numbers for the three cause-specific cardiorespiratory diseases would increase to 362,007 hospital admission cases and 3.68 billion CNY expenses ($US550 million) in the entire urban employee population (299 million) in China during 2016-2017, and the related direct economic loss of absence from work would be 798 million CNY (US$ 119.3 million).

Interpretation: Our results support that short-term exposure to ambient PM pollution could lead to significant health and economic impacts in China. Reducing levels of ambient PM can avoid substantial health damage and expenditures, and generate appreciable economic benefits from decreasing absence from work.

Funding: Natural Science Foundation of China (82073509, 71903010, 71903011), and the National Key Research and Development Program of China (2017YFC0211600, 2017YFC0211601).
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http://dx.doi.org/10.1016/j.lanwpc.2021.100232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342975PMC
October 2021

Multimorbidity, depressive symptoms and disability in activities of daily living amongst middle-aged and older Chinese: Evidence from the China Health and Retirement Longitudinal Study.

J Affect Disord 2021 12 31;295:703-710. Epub 2021 Aug 31.

Department of Health Policy and Management, School of Public Health, Peking University, Beijing, 100191, China.. Electronic address:

Background: Given that multimorbidity is strongly associated with disability in activities of daily living (ADL) and the mechanism still remains unclear, this study sought to investigate the mediating effect of depressive symptoms on such association.

Methods: A longitudinal dataset was drawn from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015), including 3951 adults aged 45 years and above. By sex, logistic regression and mediation analysis (the Karlson, Holm, and Breen Method) were employed.

Results: The presence of multimorbidity was associated with increased odds of having depressive symptoms and developing ADL disability, and depressive symptoms was significantly associated with ADL disability among middle-aged and older women. Mediation analysis illustrated that depressive symptoms accounted for 6.36% of the effect of multimorbidity on ADL disability in women.

Limitations: Results might not generalize to all middle-aged and older Chinese due to missing data on depressive symptoms and ADL.

Conclusions: Multimorbidity increased the likelihood of ADL disability onset partially through depressive symptoms in middle-aged and older women, suggesting that emphasizing mental wellness of females with multimorbidity are necessary to prevent impairments in physical function.
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http://dx.doi.org/10.1016/j.jad.2021.08.072DOI Listing
December 2021

Scalp-HFO indexes are biomarkers for the lateralization and localization of the epileptogenic zone in preoperative assessment.

J Neurophysiol 2021 10 8;126(4):1148-1158. Epub 2021 Sep 8.

Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

During the noninvasive evaluation phase for refractory epilepsy, the localization of the epileptogenic zone (EZ) is essential for the surgical protocols. Confirmation of laterality is required when the preoperative evaluation limits the EZ to bilateral anterior temporal lobes or bilateral frontal lobes. High-frequency oscillations (HFOs) are considered to be promising biological markers for the EZ. However, a large number of studies on HFOs stem from intracranial research. There were few quantitative measures for scalp HFOs, so we proposed a new method to quantify and analyze scalp HFOs. This method was called the "scalp-HFO index" (HI) and calculated in both the EZ and non-EZ. The calculation was based on the numbers and spectral power of scalp HFOs automatically detected. We labeled the brain lobes involved in the EZ as regions of interest (ROIs). The HIs based on the ripple numbers (n-HI) and spectral power (s-HI) were significantly higher in the ROI than in the contra-ROI ( = 0.012, = 0.003), indicating that HIs contributed to the lateralization of EZ. The sensitivity and specificity of n-HI for the localization of the EZ were 90% and 79.58%, respectively, suggesting that n-HI was valuable in localizing the EZ. HI may contribute to the implantation strategy of invasive electrodes. However, few scalp HFOs were recorded when the EZ was located in the medial cortex region. We proposed the scalp-high-frequency oscillation (HFO) index (HI) as a quantitative assessment method for scalp HFOs to locate the epileptogenic zone (EZ). Our results showed that the HI in regions of interest (ROIs) was significantly higher than in contra-ROIs. Sensitivity and specificity of HI based on ripple rates (n-HI) for EZ localization were 90% and 79.58%, respectively. If the n-HI of the brain region was >1.35, it was more likely to be an epileptogenic region. Clinical application of HIs as an indicator may facilitate localization of the EZ.
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http://dx.doi.org/10.1152/jn.00212.2021DOI Listing
October 2021

Socio-economic inequalities in the chronic diseases management among Chinese adults aged 45 years and above: a cross sectional study.

Arch Public Health 2021 Aug 30;79(1):157. Epub 2021 Aug 30.

Department of Health Policy and Management, School of Public Health, Peking University, Beijing, People's Republic of China.

Backgrounds: Non-communicable diseases (NCDs) have become a priority public health issue. The aim of this study was to examine whether socio-economic inequalities exist in chronic disease management among Chinese adults, and whether the relationship between SES and chronic disease management mediated by social capital.

Methods: We used combined data from China Health and Retirement Longitudinal Study (CHARLS). A total of 19,291 subjects, including 14,905 subjects from 2011 survey, 2036 subjects from 2013, and 2350 subjects from 2015 was included in this study.

Results: Subjects living in urban setting, with higher education attainment and economic status were more likely to have annual health checks, and to be diagnosed for those with hypertension, diabetes and dyslipidemia (all P < 0.05). Social participation could mediate the association between social economic status (SES) and annual health checks, diagnosis of hypertension and dyslipidemia, and health education of hypertension. Health checks could mediate the association between social participation and the diagnosis of hypertension, diabetes and dyslipidemia. The proportions of mediation were 17.5, 23.9 and 8.9%, respectively. There were no mediating effects observed from cognitive social capital variable-perceived helpfulness.

Conclusion: It is necessary to deeply reform our social security system and enhance the social capital construction to promote those low SES people's physical health.
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http://dx.doi.org/10.1186/s13690-021-00678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404245PMC
August 2021

Soluble Triggering Receptors Expressed on Myeloid Cells-1 as a Neonatal Ventilator-Associated Pneumonia Biomarker.

Int J Gen Med 2021 14;14:4529-4534. Epub 2021 Aug 14.

Department of Neonatology, Children's Hospital of Soochow University, Suzhou, 215025, Jiangsu, People's Republic of China.

Background: Neonatal ventilator-associated pneumonia (NVAP) is one of the main infections acquired in hospitals, and soluble triggering receptors expressed on myeloid cells-1 (sTREM-1) are a TREM-1 subtype that can be released into the blood or bodily fluids during an infection.

Methods: The patients included in the present study were divided into three groups: the NVAP group, the first control group, and the second control group (n = 20, each). Children requiring respiratory treatment were assigned to the NVAP group, newborns who received mechanical ventilation and had neonatal respiratory distress syndrome were assigned to the first control group, and newborns with normal X-ray and electrocardiogram results but no non-pulmonary infection was assigned to the second control group. The blood and bronchoalveolar lavage fluid (BALF) sTREM-1 levels in all newborns were analyzed.

Results: The acute-phase blood and BALF sTREM-1 levels were significantly higher in the NVAP group than in the first control group, and the blood sTREM-1 expression level was lower in the second control group than in the NVAP group.

Conclusion: The present results suggest that sTREM-1 might be a useful biomarker for NVAP prediction in the Department of Pediatrics.
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http://dx.doi.org/10.2147/IJGM.S315987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372303PMC
August 2021

Brain-Targeted Polysorbate 80-Emulsified Donepezil Drug-Loaded Nanoparticles for Neuroprotection.

Nanoscale Res Lett 2021 Aug 18;16(1):132. Epub 2021 Aug 18.

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province and Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, 410013, China.

Most Alzheimer's disease drugs do not work efficiently because of the blood-brain barrier. Therefore, we designed a new nanopreparation (PS-DZP-CHP): cholesterol-modified pullulan (CHP) nanoparticle with polysorbate 80(PS) surface coverage, as donepezil (DZP) carrier to realize brain tissue delivery. By size analysis and isothermal titration calorimetry, we chose the optimal dosing ratio of the drug with nanomaterials (1:5) and designed a series of experiments to verify the efficacy of the nanoparticles. The results of in vitro release experiments showed that the nanoparticles can achieve continuous drug release within 72 h. The results of fluorescence observation in mice showed a good brain targeting of PS-DZP-CHP nanoparticles. Furthermore, the nanoparticle can enhance the drug in the brain tissue concentration in mice. DZP-CHP nanoparticles were used to pretreat nerve cells with Aβ protein damage. The concentration of lactate dehydrogenase was determined by MTT, rhodamine 123 and AO-EB staining, which proved that DZP-CHP nanoparticles had a protective effect on the neurotoxicity induced by Aβ and were superior to free donepezil. Microthermal perpetual motion meter test showed that PS-DZP-CHP nanoparticles have an affinity with apolipoprotein E, which may be vital for this nanoparticle targeting to brain tissue.
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http://dx.doi.org/10.1186/s11671-021-03584-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374023PMC
August 2021

Broadband achromatic metalens design based on deep neural networks.

Opt Lett 2021 Aug;46(16):3881-3884

For the design of achromatic metalenses, one key challenge is to accurately realize the wavelength dependent phase profile. Because of the demand of tremendous simulations, traditional methods are laborious and time consuming. Here, a novel deep neural network (DNN) is proposed and applied to the achromatic metalens design, which turns complex design processes into regression tasks through fitting the target phase curves. During training, - projection pairs are put forward to solve the phase jump problem, and some additional phase curves are manually generated to optimize the DNN performance. To demonstrate the validity of our DNN, two achromatic metalenses in the near-infrared region are designed and simulated. Their average focal length shifts are 2.6% and 1.7%, while their average relative focusing efficiencies reach 59.18% and 77.88%.
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http://dx.doi.org/10.1364/OL.427221DOI Listing
August 2021

The impact of the reference pricing policy in China on drug procurement and cost.

Health Policy Plan 2022 Jan;37(1):73-99

High drug costs are putting pressures on health care budgets and posing an obstacle for China to achieve universal coverage. Policies such as the direct price ceiling, and the Essential Medicines Program-with the Zero Markup Drug Policy (ZMDP) one key component-were implemented, coming out with limited evidence for a success. As a benchmark of China's recent health reform, Sanming city initiated the ZMDP in January 2013; and further piloted the first reference pricing (RP) policy in China in September 2014, with the intention to dis-incentivize the use of costly original drugs. In this study, we used hospital-based drug procurement data of 14 drug substances that were subjected to the RP, from four hospitals in Sanming and a neighbouring city Longyan, between 2012 and 2016. Adopting the difference-in-difference (DID) approach, we evaluated the impacts of the RP together with the ZMDP. On the one hand, we found that the ZMDP had no impact on drugs' procurement prices, volumes and costs. While on the other hand, we found that the introduction of RP was not associated with changes in unit prices for the 14 drugs in Sanming. However, the RP pilot was associated with a 25.9% [95% confidence interval (CI), 12.9-37.0%] decrease in monthly drug procurement volumes and a 47.7% (95% CI, 33.7-58.7%) decrease in the total drug costs. In particular, it reduced the procurement volumes of original drugs by 56.8% (95% CI, 47.0-64.7%). Subgroup analyses by hospital level and therapeutic class found similar results. We draw lessons for the Chinese government to experiment RP on a larger scale, considering the development and effective regulation of the generic market. This is a first report on the effects of RP in China, Asia and middle-income countries.
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http://dx.doi.org/10.1093/heapol/czab012DOI Listing
January 2022

Effect of phosphogypsum on the properties of magnesium phosphate cement paste with low magnesium-to-phosphate ratio.

Sci Total Environ 2021 Dec 28;798:149262. Epub 2021 Jul 28.

School of Architecture and Planning, Yunnan University, Kunming 650051, China. Electronic address:

The incorporation of phosphogypsum (PG) in magnesium potassium phosphate cement (MPPC) can promote the utilization of PG not only by utilising the phosphate impurity in PG, but also by immobilising the heavy metals with MPPC. This paper investigates the feasibility of the incorporation of PG in preparing MPPC. Both early age properties, including workability and setting time, and hardened properties of compressive strength and microstructure, of PG-incorporated MPPC paste were investigated, and the hydration mechanism was explored. The results indicated that the addition of PG increased the workability of MPPC and extended the setting time of MPPC. However, incorporation of 20% PG slightly reduced the compressive strength because higher PG content led to the loose microstructure. Moreover, the addition of PG did not change the formation of hydration product, while it only reduced the hydration heat. Finally, compared to PG, the concentration of leached heavy metals of MPPC with PG was significantly reduced after 28 days curing.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149262DOI Listing
December 2021

Evaluation of a pilot program that integrated prenatal screening into routine antenatal care in western rural China: an interrupted time-series study.

Lancet Reg Health West Pac 2021 Jan 24;6:100075. Epub 2020 Dec 24.

Department head, Department of Maternal and Child Health, Health Commission of the Shaanxi Province, China.

Background: We evaluated a large-scale pilot program in Shaanxi Province, western rural China, which integrated prenatal screening interventions for congenital abnormalities into routine antenatal programs.

Methods: We surveyed 1,597 mothers who gave birth between 2009 and 2016. Adopting the interrupted time-series design, we evaluated the program's impact on awareness, coverage, and cost, by comparing two counties with only supply-side policies, and two counties from the neighbouring province with no policies; and among the two counties with both supply- and demand-side policies and the two counties with only supply-side policies. We adjusted the sampling procedure and women's background characteristics. We conducted subgroup analyses by women's education.

Findings: After one year of implementation, the coverage of prenatal foetal aneuploidies and B-ultrasound screening rose by 25.0% and 23.5%. The program's supply-side policies attributed to 17.2 percentage points (90%CI 7.8-26.6%) and 27.3 percentage points (90%CI 16.2-38.5%) in coverage, and contributed to a higher median cost of 796.5RMB (90%CI 595.5-997.5). These significantly affected women with secondary education and above. However, the program's demand-side measures, that is, vouchers, seemed to be effective only in the mountainous regions, which raised awareness, and increased coverage of prenatal foetal aneuploidies screening by 28.6 percentage points (90%CI 13.4-43.8%), while not increasing costs. These significantly affected women with primary education and below. Education-related inequalities widened post-program in counties with only supply-side policies, but no inequalities existed in counties with demand-side policies.

Interpretation: Shaanxi's program made a pilot study to other provinces of China to integrate antenatal services. Government subsidies might be more effective in targeting specific geographic locations and people with primary education and lower.
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http://dx.doi.org/10.1016/j.lanwpc.2020.100075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315490PMC
January 2021

CircRIP2 promotes NSCLC progression by sponging for miR-671-5p to regulate FOXM1 expression.

Histol Histopathol 2021 Jul 22:18360. Epub 2021 Jul 22.

Department of Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Lot of attention had been paid to the role of circular RNAs (circRNAs) in carcinogenesis recently. However, knowledge about circRNAs in NSCLC development is far from satisfactory. In this study, we aimed to provide a novel insight into the circRIP2 in NSCLC development. We used NSCLC tissues, as well as cell lines to elucidate the expression and location of circRIP2 in NSCLC. We also established the circRIP2 overexpression cells A549-circRIP2 and repression cells HCC827-shcircRIP2 for further functional and mechanism studies. The pro-tumorigenic role of circRIP2 was tested by using CCK-8, BrdU and transwell assays. The interaction between circRIP2 and miR-671-5p were validated by luciferase reporter assay, RIP assay, as well as RNA pull down assay. We showed circRIP2 is differentially expressed NSCLC, and acted as a predictor for overall survival (OS) and disease-free survival (DFS). CircRIP2 promoted NSCLC progression by acting as a miRNA sponge for miR-671-5p, thus facilitating its target gene FOXM1 expression. Targeting circRIP2 could be potentially beneficial for NSCLC patients in the future.
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http://dx.doi.org/10.14670/HH-18-360DOI Listing
July 2021

MiR-375-3p mediates reduced pineal function in hypoxia-ischemia brain damage.

Exp Neurol 2021 10 17;344:113814. Epub 2021 Jul 17.

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215000, China. Electronic address:

The functional roles of microRNAs (miRNAs) have been studied in various diseases, including hypoxic-ischemic brain damage (HIBD). However, changes in the expression of miRNAs and the underlying mechanisms in the pineal gland during HIBD remain unknown. Based on the previous study by microRNA array, hundreds of miRNAs showed altered expression patterns in the pineal gland in a rat model of HIBD. MiR-375-3p was found to be significantly upregulated and abundant in the pineal gland. Further investigation in an in vitro HI model of pinealocytes showed that miRNA-375 exacerbated the damage to pineal function. After oxygen-glucose deprivation / reoxygenation (OGD/R), miR-375-3p expression increased, while aralkylamine N-acetyltransferase (AANAT) expression and melatonin (MT) secretion decreased. Overexpression of miRNA-375 in pinealocytes aggravated the influence of OGD/R on AANAT expression and MT secretion. Because miRNA-375 overexpression in pinealocytes induced decreased rasd1 mRNA and protein expression, rasd1 may mediate the effect of miR-375-3p on pineal function. Furthermore, miR-375-3p aggravated the cognitive impairment caused by HIBD in rats, as observed by Morris water maze test, and also affected emotion and circadian rhythm in HIBD-treated rats. Thus, miR-375-3p may be a key regulatory molecule in the pineal gland following HIBD, and targeting of miR-375-3p may represent a new strategy for the treatment of HIBD.
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http://dx.doi.org/10.1016/j.expneurol.2021.113814DOI Listing
October 2021

Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-β in mild cognitive impairment but not in Alzheimer's disease.

J Integr Neurosci 2021 Jun;20(2):277-286

Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, China.

Apolipoprotein E is the most well-established genetic risk factor for Alzheimer's disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial. The research checks the hypothesis that the relationships between apolipoprotein E alleles and cerebrospinal fluid tau and cognition differ in persons with and without significant amyloid-β deposition. We divided 1119 subjects into cognitively normal (n = 275), mild cognitive impairment (n = 629), and Alzheimer's disease (n = 215), and these subjects were from the Alzheimer's Disease Neuroimaging Initiative database. Linear regression models were used to compare the relationships of apolipoprotein E alleles with cerebrospinal fluid tau and cognition in persons with significant amyloid-β deposition relative to individuals without significant amyloid-β deposition. The associations of apolipoprotein E ε4 and ε3 with total tau (T-tau), phosphorylated tau (P-tau), and Alzheimer's disease assessment scale was significantly substantial among participants with significant amyloid-β deposition. Stratified analyses showed that apolipoprotein E ε4 related to increased concentrations of T-tau, P-tau, and Alzheimer's disease assessment scale and apolipoprotein E ε3 associated with decreased concentrations of T-tau, P-tau, and Alzheimer's disease assessment scale in mild cognitive impairment participants with significant amyloid-β deposition, but not in Alzheimer's disease. Our study shows that the presence of apolipoprotein E ε4 and ε3 alleles is related to tau pathology and cognitive impairment in the presence of amyloid-β in mild cognitive impairment, but not in Alzheimer's disease. This work indirectly provides additional evidence that apolipoprotein E and amyloid-β may not have a role in modulating clinical Alzheimer's disease, and apolipoprotein E ε3 may be supposed to be protective to mild cognitive impairment.
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http://dx.doi.org/10.31083/j.jin2002027DOI Listing
June 2021

Synergistic Enhancement of Fluorescence and Magnetic Resonance Signals Assisted by Albumin Aggregate for Dual-Modal Imaging.

ACS Nano 2021 06 7;15(6):9924-9934. Epub 2021 Jun 7.

State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, AIE Institute, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou 510640, China.

Dual-modal fluorescence and magnetic resonance imaging (FLI/MRI) is important for the early diagnosis of malignant tumors. However, facile and opportune strategies to synergistically enhance fluorescence intensity and magnetic resonance (MR) contrast have rarely been reported. Herein, we present a facile strategy using albumin aggregates (AAs) to synergistically enhance the fluorescence intensity by aggregation-induced emission (AIE) and MR contrast with prolonged rotational correlation time (τ) of Gd(III) chelates and the diffusion correlation time (τ) of surrounding water molecules. The amphiphilic dual-modal FLI/MRI probe of NGd was facilely loaded into albumin pockets and then formed AAs to generate a supramolecular structure of NGd-albumin aggregates (NGd-AAs), which show excellent biocompatibility and biosafety, and exhibit superior fluorescence quantum yield and over NGd with 6- and 8-fold enhancement, respectively. Moreover, compared with the clinical MRI contrast agent Gd-DOTA, of NGd-AAs showed a 17-fold enhancement. Therefore, NGd-AAs successfully elicited high-performance dual-modal FLI/MRI and and high contrast MR signals were observed in the liver and tumor after intravenous injection of NGd-AAs at a dosage of 6 μmol Gd(III)/kg body weight. This generic and feasible strategy successfully realized a synergistic effect for dual-modal FLI/MRI.
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http://dx.doi.org/10.1021/acsnano.1c01251DOI Listing
June 2021

Dynamic Coordination between a Triphenylamine-Functionalized Salicylaldehyde Schiff Base and a Copper(II) Ion.

Inorg Chem 2021 Jun 7;60(12):8581-8591. Epub 2021 Jun 7.

Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, School of Material and Energy, Guangdong University of Technology, Guangzhou 510006, P. R. China.

The coordination between a ligand and a metal is a spontaneous and uncontrollable process. In this Article, we successfully observe the formation of metal coordination in a triphenylamine-functionalized salicylaldehyde Schiff base with a copper(II) ion. The ligand first reacts with Cu in a stepwise process to afford the dynamic complex ([ligand]:[Cu] = 1:1), which further reacts with an extra copper(II) ion to afford with the following stepwise (or cumulative) stability constants: = 4.0694 × 10 and = 1.0761 × 10, respectively. The entire metal coordination process can be visualized, and the coordination mode of the probe toward copper was further evaluated by ultraviolet-visible/fluorescence spectra, single-crystal X-ray diffraction, density functional theory calculations, high-resolution mass spectra, and nuclear magnetic resonance spectroscopic titrations. Compound exhibited excellent sensitivity and specificity toward copper(II) ions in THF/water media with a low limit of detection of 2.687 × 10 mol L. In addition, can be applied to the detection of Cu in real samples with satisfactory recoveries in the range of 100-112% in lake water and 98-101% in tap water. This Article not only reports an excellent fluorescence probe for copper(II) ion detection but also presents an instance for more fully understanding the metal coordination process.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00523DOI Listing
June 2021

Cement-Based Piezoelectric Ceramic Composites for Sensing Elements: A Comprehensive State-of-the-Art Review.

Sensors (Basel) 2021 May 7;21(9). Epub 2021 May 7.

Guangdong Province Key Laboratory of Durability for Marine Civil Engineering, College of Civil and Transportation Engineering, Shenzhen University, Shenzhen 518060, China.

Compatibility, a critical issue between sensing material and host structure, significantly influences the detecting performance (e.g., sensitive, signal-to-noise ratio) of the embedded sensor. To address this issue in concrete-based infrastructural health monitoring, cement-based piezoelectric composites (piezoelectric ceramic particles as a function phase and cementitious materials as a matrix) have attracted continuous attention in the past two decades, dramatically exhibiting superior durability, sensitivity, and compatibility. This review paper performs a synthetical overview of recent advances in theoretical analysis, characterization and simulation, materials selection, the fabrication process, and application of the cement-based piezoelectric composites. The critical issues of each part are also presented. The influencing factors of the materials and fabrication process on the final performance of composites are further discussed. Meanwhile, the application of the composite as a sensing element for various monitoring techniques is summarized. Further study on the experiment and simulation, materials, fabrication technique, and application are also pointed out purposefully.
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http://dx.doi.org/10.3390/s21093230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124618PMC
May 2021

Interfacial Binding Energy between Calcium-Silicate-Hydrates and Epoxy Resin: A Molecular Dynamics Study.

Polymers (Basel) 2021 May 21;13(11). Epub 2021 May 21.

Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering, College of Civil and Transportation Engineering, Shenzhen University, Shenzhen 518060, China.

Microcapsules encapsulated within epoxy as a curing agent have been successfully applied in self-healing materials, in which the healing performance significantly depends on the binding behaviour of the epoxy curing agent with the cement matrix. In this paper, the binding energy was investigated by molecular dynamics simulation, which could overcome the shortcomings of traditional microscopic experimental methods. In addition to the construction of different molecular models of epoxy, curing agents, and dilutants, seven models were established to investigate the effects of chain length, curing agent, and epoxy resin chain direction on the interfacial binding energy. The results showed that an increase of chain length exhibited had limited effect on the binding energy, while the curing agent and the direction of the epoxy significantly affected the interfacial binding energy. Among different factors, the curing agent tetrethylenepentamine exhibited the highest value of interfacial binding energy by an increment of 31.03 kcal/mol, indicating a better binding ability of the microcapsule core and the cement matrix. This study provides a microscopic insight into the interface behaviour between the microcapsule core and the cement matrix.
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http://dx.doi.org/10.3390/polym13111683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196693PMC
May 2021

An Air-Stable Organic Radical from a Controllable Photoinduced Domino Reaction of a Hexa-aryl Substituted Anthracene.

J Org Chem 2021 Jun 25;86(11):7359-7369. Epub 2021 May 25.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Air-stable organic radicals and radical ions have attracted great attention for their far-reaching application ranging from bioimaging to organic electronics. However, because of the highly reactive nature of organic radicals, the design and synthesis of air-stable organic radicals still remains a challenge. Herein, an air-stable organic radical from a controllable photoinduced domino reaction of a hexa-aryl substituted anthracene is described. The domino reaction involves a photoinduced [4 + 2] cycloaddition reaction, rearrangement, photolysis, and an elimination reaction; H/C NMR spectroscopy, high resolution mass spectrometry, single-crystal X-ray diffraction, and EPR spectroscopy were exploited for characterization. Furthermore, a photoinduced domino reaction mechanism is proposed according to the experimental and theoretical studies. In addition, the effects of employing push and pull electronic groups on the controllable photoinduced domino reaction were investigated. This article not only offers a new blue emitter and novel air-stable organic radical compound for potential application in organic semiconductor applications, but also provides a perspective for understanding the fundamentals of the reaction mechanism on going from anthracene to semiquinone in such anthracene systems.
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http://dx.doi.org/10.1021/acs.joc.1c00233DOI Listing
June 2021

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.

Anal Cell Pathol (Amst) 2021 1;2021:5589532. Epub 2021 May 1.

Department of Cardiothoracic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006, China.

The expression of G2 and S phase-expressed-1 (GTSE1) was upregulated in human cancer. However, its expression and roles in lung cancer have not been identified yet. In our study, we reported that GTSE1 expression was statistically higher in lung tissues than in the adjacent noncancerous tissues which might be a consequence of hypomethylation of the GTSE1 promoter. The upregulated expression of GTSE1 mRNA predicted the poorer survival of the lung patients. Ectopic expression of GTSE1 in lung cancer cells significantly increased while knockdown of GTSE1 decreased cell proliferation, cell migration, and cell invasion in H460 and A549 cells. Furthermore, knockdown of GTSE1 regulated the cell cycle and promoted cell apoptosis in H460 and A549 cells. Finally, we presented that GTSE1 was able to activate AKT/mTOR signaling in H460 and A549 cells. In conclusion, these results indicated that the overexpressed GTSE1 was involved in the progress of lung cancer by promoting proliferation migration and invasion and inhibiting apoptosis of lung cancer cells via activating AKT/mTOR signaling.
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http://dx.doi.org/10.1155/2021/5589532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110388PMC
December 2021

Relationship Between Risk Perception, Social Support, and Mental Health Among General Chinese Population During the COVID-19 Pandemic.

Risk Manag Healthc Policy 2021 7;14:1843-1853. Epub 2021 May 7.

Department of Health Policy and Management, School of Public Health, Peking University, Beijing, People's Republic of China.

Background: The Coronavirus Diseases (COVID-19) pandemic is a global public health challenge and provides an opportunity to investigate the unclear relationship between risk perception, social support, and mental health. This study aims to examine the association between risk perception and mental health while taking social support as a moderator.

Methods: An online cross-sectional study recruiting 2993 participants was conducted in China, from 1st to 10th, February 2020. The relationship between risk perception, social support, and mental health was examined using multivariate linear regression analyses.

Results: This study indicated that risk perception was associated with a higher level of mental health symptoms. The subscale "Perceived uncontrollability" seemed to present a stronger correlation with depressive symptoms (Beta=0.306) and post-traumatic stress disorder (PTSD) symptoms (Beta=0.318) than the subscale "Perceived Severity" did. Moreover, social support moderated the relationship between perceived uncontrollability and mental health symptoms.

Conclusion: In the context of the COVID-19 pandemic, it is necessary to design mental health strategies and programs from a risk perception perspective (more mental health strategies should be delivered to build reasonable risk perception), while social support from family and friends may be protective to against depressive symptoms and PTSD symptoms. There is a demand for mental health intervention from a risk perception perspective.
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http://dx.doi.org/10.2147/RMHP.S302521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114362PMC
May 2021

Trivalent Chromium Ions Doped Fluorides with Both Broad Emission Bandwidth and Excellent Luminescence Thermal Stability.

ACS Appl Mater Interfaces 2021 Apr 8;13(15):18274-18282. Epub 2021 Apr 8.

Experimental Teaching Department, Guangdong University of Technology, Waihuan Xi Road, No. 100, Guangzhou 510006, PR China.

Recently, trivalent chromium ion doped phosphors have exhibited significant application potential in broadband near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs). However, developing an NIR phosphor with both broad emission bandwidth and excellent luminescence thermal stability is still a great challenge. Here, we demonstrate an NIR phosphor, ScF:Cr, which can fulfill both conditions simultaneously. The prepared phosphors show broadband emission in the range of 700 to 1100 nm, with a full width at half-maximum (FWHM) of 140 nm peaking at 853 nm. These phosphors also demonstrate an excellent luminescence thermal stability (the emission intensity of ScF:Cr keeps 85.5% at 150 °C compared with the value at room temperature). An NIR pc-LED based on blue LED chips was fabricated and tested. The results show that the NIR pc-LED can yield strong broadband NIR emission. This work not only provides a promising phosphor for the application of NIR pc-LEDs but also has important guiding significance for effect of synthesis conditions on the luminescence properties of Cr-doped fluorides.
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http://dx.doi.org/10.1021/acsami.1c01417DOI Listing
April 2021

Magnetic resonance quantitative susceptibility mapping in the evaluation of hepatic fibrosis in chronic liver disease: a feasibility study.

Quant Imaging Med Surg 2021 Apr;11(4):1170-1183

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China.

Background: Noninvasive methods for the early diagnosis and staging of hepatic fibrosis are needed. The present study aimed to investigate the alteration of magnetic susceptibility in the liver of patients with various fibrosis stages and to evaluate the feasibility of using susceptibility to stage hepatic fibrosis.

Methods: A total of 30 consecutive patients with chronic liver diseases (CLDs) underwent magnetic resonance imaging (MRI) and liver biopsy evaluation of hepatic fibrosis, necroinflammatory activity, iron load, and steatosis. Quantitative susceptibility mapping (QSM), R2* and proton density fat fraction (PDFF) images were postprocessed from the same gradient-echo data for quantitative tissue characterization using region of interest (ROI) analysis. The differences for MRI measurements between cohorts of non-significant (Ishak-F <3) and significant fibrosis (Ishak-F ≥3) and the correlation of MRI measurements with fibrosis stages and necroinflammatory activity grades were tested. Receiver operating characteristic (ROC) analysis was also performed.

Results: There was a significant difference in liver susceptibility between the cohorts of significant and non-significant fibrosis (Z=-2.880, P=0.004). A moderate negative correlation between the stages of liver fibrosis and liver susceptibility was observed (r=-0.471, P=0.015). Liver magnetic susceptibility differentiated non-significant from significant hepatic fibrosis with an area under the receiver operating curve (AUC) of 0.836 (P=0.004). A highly sensitive diagnostic performance with an AUC of 0.933 was obtained using magnetic susceptibility and PDFF together (P<0.001).

Conclusions: A noninvasive liver QSM-based evaluation promises an accurate assessment of significant fibrosis in patients with CLDs.
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http://dx.doi.org/10.21037/qims-20-720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930689PMC
April 2021

The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage.

Neural Regen Res 2021 Oct;16(10):2071-2077

Soochow Key Laboratory of Prevention and Treatment of Child Brain injury, Children's Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Circadian rhythm disorder is a common, but often neglected, consequence of neonatal hypoxic-ischemic brain damage (HIBD). However, the underlying molecular mechanisms remain largely unknown. We previously showed that, in a rat model of HIBD, up-regulation of microRNA-325 (miR-325) in the pineal gland is responsible for the suppression of Aanat, a key enzyme involved in melatonin synthesis and circadian rhythm regulation. To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD, we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University (Dushuhu Branch) in 2019. We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD. Furthermore, a luciferase reporter gene assay revealed that LIM homeobox 3 (LHX3) is a novel downstream target of miR-325. In addition, in miR-325 knock-down mice, the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland. We established a neonatal mouse model of HIBD by performing double-layer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours. Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions. Finally, we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3. Taken together, our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD. The clinical trial was approved by Institutional Review Board of Children's Hospital of Soochow University (approval No. 2015028) on July 20, 2015. Animal experiments were approved by Animal Care and Use Committee, School of Medicine, Soochow University, China (approval No. XD-2016-1) on January 15, 2016.
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http://dx.doi.org/10.4103/1673-5374.308101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343300PMC
October 2021
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