Xin-Yuan Guan

Xin-Yuan Guan

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Xin-Yuan Guan

Publications by authors named "Xin-Yuan Guan"

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HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma.

Cell Death Differ 2019 Nov 18;26(11):2268-2283. Epub 2019 Feb 18.

State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.

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http://dx.doi.org/10.1038/s41418-019-0301-1DOI Listing
November 2019

Epigenetic alterations of a novel antioxidant gene predispose susceptible individuals to increased risk of esophageal cancer.

Int J Biol Sci 2018 7;14(12):1658-1668. Epub 2018 Sep 7.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Carson International Cancer Center, Shenzhen University School of Medicine, Shenzhen 518039, China.

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http://dx.doi.org/10.7150/ijbs.28482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216027PMC
September 2019

Therapeutic targeting of the crosstalk between cancer-associated fibroblasts and cancer stem cells.

Am J Cancer Res 2019 1;9(9):1889-1904. Epub 2019 Sep 1.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Shenzhen International Cancer Center, Shenzhen University School of Medicine Shenzhen, China.

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September 2019

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma.

BMC Cancer 2019 Aug 28;19(1):851. Epub 2019 Aug 28.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1186/s12885-019-6041-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714407PMC
August 2019

Membrane Metalloendopeptidase (MME) Suppresses Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) by Inhibiting FAK-RhoA Signaling Axis.

Am J Pathol 2019 Jul 2;189(7):1462-1472. Epub 2019 May 2.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.04.007DOI Listing
July 2019

Defining early events of Epstein-Barr virus (EBV) infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection.

J Gen Virol 2019 Jun 28;100(6):999-1012. Epub 2019 Feb 28.

4​School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, PR China.

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http://dx.doi.org/10.1099/jgv.0.001243DOI Listing
June 2019

Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma.

Oncogene 2019 04 8;38(17):3119-3133. Epub 2019 Jan 8.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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http://www.nature.com/articles/s41388-018-0648-7
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http://dx.doi.org/10.1038/s41388-018-0648-7DOI Listing
April 2019

C-terminal truncated HBx protein activates caveolin-1/LRP6/β-catenin/FRMD5 axis in promoting hepatocarcinogenesis.

Cancer Lett 2019 Mar 21;444:60-69. Epub 2018 Dec 21.

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.12.003DOI Listing
March 2019

APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production.

J Clin Invest 2019 Feb 14;129(2):727-743. Epub 2019 Jan 14.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

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http://www.jci.org/articles/view/122478
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http://dx.doi.org/10.1172/JCI122478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355227PMC
February 2019

CHD1L contributes to cisplatin resistance by upregulating the ABCB1-NF-κB axis in human non-small-cell lung cancer.

Cell Death Dis 2019 Feb 4;10(2):99. Epub 2019 Feb 4.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.

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http://dx.doi.org/10.1038/s41419-019-1371-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362241PMC
February 2019

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling.

Gynecol Oncol 2019 01 12;152(1):185-193. Epub 2018 Nov 12.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183135
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http://dx.doi.org/10.1016/j.ygyno.2018.10.039DOI Listing
January 2019

SOX9 is a dose-dependent metastatic fate determinant in melanoma.

J Exp Clin Cancer Res 2019 Jan 14;38(1):17. Epub 2019 Jan 14.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0998-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330758PMC
January 2019

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.

Theranostics 2019 24;9(3):796-810. Epub 2019 Jan 24.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510062, China.

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http://dx.doi.org/10.7150/thno.28992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376468PMC
January 2019

Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma.

Int J Cancer 2018 12 15;143(12):3209-3217. Epub 2018 Nov 15.

Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1002/ijc.31642DOI Listing
December 2018

ApoA-1 accelerates regeneration of small-for-size fatty liver graft after transplantation.

Life Sci 2018 Dec 26;215:128-135. Epub 2018 Oct 26.

Department of Surgery, The University of Hong Kong, Hong Kong, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183068
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http://dx.doi.org/10.1016/j.lfs.2018.10.053DOI Listing
December 2018

RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression.

Theranostics 2018 1;8(1):185-198. Epub 2018 Jan 1.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.7150/thno.21383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743468PMC
November 2018

Down-regulation of Predicts Poor Prognosis of Hepatocellular Carcinoma Patients.

Hepatol Commun 2018 Nov 2;2(11):1408-1414. Epub 2018 Oct 2.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine the University of Hong Kong Hong Kong.

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http://doi.wiley.com/10.1002/hep4.1242
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http://dx.doi.org/10.1002/hep4.1242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211329PMC
November 2018

CSTF2-Induced Shortening of the 3'UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder.

Cancer Res 2018 10 24;78(20):5848-5862. Epub 2018 Aug 24.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0822DOI Listing
October 2018

Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis.

Proc Natl Acad Sci U S A 2018 09 29;115(38):E8948-E8957. Epub 2018 Aug 29.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, 510060 Guangzhou, China;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1806219115
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http://dx.doi.org/10.1073/pnas.1806219115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156672PMC
September 2018

Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism.

Cancer Res 2018 08 2;78(16):4471-4481. Epub 2018 Jul 2.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2172DOI Listing
August 2018

Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients.

Mol Carcinog 2018 07 6;57(7):886-895. Epub 2018 Apr 6.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.

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http://dx.doi.org/10.1002/mc.22809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001627PMC
July 2018

High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma.

Thorac Cancer 2018 07 2;9(7):775-784. Epub 2018 May 2.

State Key Laboratory of Oncology, South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1111/1759-7714.12643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026602PMC
July 2018

Hypoxia restrains the expression of complement component 9 in tumor-associated macrophages promoting non-small cell lung cancer progression.

Cell Death Discov 2018 7;4:63. Epub 2018 Jun 7.

1State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060 Guangzhou, China.

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http://dx.doi.org/10.1038/s41420-018-0064-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992192PMC
June 2018

TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling.

Nat Commun 2018 04 12;9(1):1423. Epub 2018 Apr 12.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 510062, Guangzhou, China.

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http://dx.doi.org/10.1038/s41467-018-03716-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897412PMC
April 2018

Eukaryotic Initiation Factor 5A2 Contributes to the Maintenance of CD133(+) Hepatocellular Carcinoma Cells via the c-Myc/microRNA-29b Axis.

Stem Cells 2018 02 20;36(2):180-191. Epub 2017 Nov 20.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1002/stem.2734DOI Listing
February 2018

The Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma.

Clin Cancer Res 2018 02 13;24(3):659-673. Epub 2017 Nov 13.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796860PMC
February 2018

Overexpression of MUC13, a Poor Prognostic Predictor, Promotes Cell Growth by Activating Wnt Signaling in Hepatocellular Carcinoma.

Am J Pathol 2018 02 22;188(2):378-391. Epub 2017 Nov 22.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Republic of China; Department of Clinical Oncology, the University of Hong Kong, Hong Kong, Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173041
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http://dx.doi.org/10.1016/j.ajpath.2017.10.016DOI Listing
February 2018

Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.

Cancer Res 2017 11 13;77(21):5831-5845. Epub 2017 Sep 13.

Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-0579DOI Listing
November 2017

Overexpression of HN1L promotes cell malignant proliferation in non-small cell lung cancer.

Cancer Biol Ther 2017 Nov 20;18(11):904-915. Epub 2017 Oct 20.

a State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , China.

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http://dx.doi.org/10.1080/15384047.2017.1385678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710669PMC
November 2017

Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.

Thorac Cancer 2017 07 16;8(4):344-349. Epub 2017 May 16.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1111/1759-7714.12453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494452PMC
July 2017

Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma.

Oncotarget 2017 Jun;8(26):42300-42313

Institute of Biomedicine & Department of Cell Biology, Jinan University, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.15857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522068PMC
June 2017

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.

Nat Commun 2017 02 10;8:14399. Epub 2017 Feb 10.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

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http://dx.doi.org/10.1038/ncomms14399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309924PMC
February 2017

SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.

Cancer Lett 2017 01 3;385:271-279. Epub 2016 Oct 3.

Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.09.032DOI Listing
January 2017

Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells.

Hepatology 2016 12 27;64(6):2062-2076. Epub 2016 Oct 27.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1002/hep.28821DOI Listing
December 2016

Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.

Nat Commun 2016 12 7;7:13568. Epub 2016 Dec 7.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 852, China.

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http://dx.doi.org/10.1038/ncomms13568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150658PMC
December 2016

Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma.

Expert Opin Ther Targets 2016 15;20(1):7-18. Epub 2015 Dec 15.

a School of Biomedical Sciences, Li Ka Shing Faculty of Medicine , The University of Hong Kong , Pokfulam , Hong Kong SAR , China.

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http://dx.doi.org/10.1517/14728222.2016.1121236DOI Listing
September 2016

Expression of EIF5A2 associates with poor survival of nasopharyngeal carcinoma patients treated with induction chemotherapy.

BMC Cancer 2016 08 22;16:669. Epub 2016 Aug 22.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

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http://dx.doi.org/10.1186/s12885-016-2714-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994420PMC
August 2016

Corrigendum to "Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma" [J Hepatol 2015;62:607-616].

J Hepatol 2016 Jun 16;64(6):1461. Epub 2016 Mar 16.

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.02.038DOI Listing
June 2016

CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma.

Carcinogenesis 2016 06 31;37(6):557-566. Epub 2016 Mar 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

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http://dx.doi.org/10.1093/carcin/bgw036DOI Listing
June 2016

Characterization of oncogene-induced metabolic alterations in hepatic cells by using ultrahigh performance liquid chromatography-tandem mass spectrometry.

Talanta 2016 May 28;152:119-26. Epub 2016 Jan 28.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2016.01.056DOI Listing
May 2016

Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.

Gut 2016 Apr 6;65(4):635-46. Epub 2015 May 6.

Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1136/gutjnl-2014-308257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819609PMC
April 2016

Proteomic analysis of a nasopharyngeal carcinoma cell line and a nasopharyngeal epithelial cell line.

Tumori 2015 Nov-Dec;101(6):676-83. Epub 2015 Jun 6.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center of Cancer Medicine, Guangzhou - PR China.

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http://dx.doi.org/10.5301/tj.5000345DOI Listing
March 2016

Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.

Clin Cancer Res 2016 Mar 16;22(5):1243-55. Epub 2015 Oct 16.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China. Centre for Cancer Research, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

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http://clincancerres.aacrjournals.org/content/early/2015/10/
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http://clincancerres.aacrjournals.org/content/early/2015/12/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1196DOI Listing
March 2016

CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction.

Oncotarget 2016 Mar;7(13):15525-38

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.6900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941258PMC
March 2016

PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma.

Carcinogenesis 2016 Mar 19;37(3):320-332. Epub 2016 Jan 19.

Shenzhen Key Laboratory of Translational Medicine of Tumor and Cancer Research Centre, School of Medicine, Shenzhen University , Shenzhen 518000 , China.

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http://dx.doi.org/10.1093/carcin/bgw010DOI Listing
March 2016

Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions.

Sci Rep 2016 Feb 16;6:21184. Epub 2016 Feb 16.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR.

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http://dx.doi.org/10.1038/srep21184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754761PMC
February 2016

CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy.

BMC Cancer 2016 Jan 13;16:15. Epub 2016 Jan 13.

State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, PR China.

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http://dx.doi.org/10.1186/s12885-016-2050-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711109PMC
January 2016

Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.

Gastroenterology 2015 Oct 20;149(4):1068-81.e5. Epub 2015 Jun 20.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.06.010DOI Listing
October 2015

HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma.

Carcinogenesis 2015 Oct 5;36(10):1111-20. Epub 2015 Aug 5.

Department of Clinical Oncology, State Key Laboratory for Liver Research, Center for Cancer Research, The University of Hong Kong, Hong Kong, China, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China and

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http://dx.doi.org/10.1093/carcin/bgv116DOI Listing
October 2015

Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival.

Oncotarget 2015 Oct;6(31):31181-90

The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.5070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741596PMC
October 2015

Prognostic significance of FAM3C in esophageal squamous cell carcinoma.

Diagn Pathol 2015 Oct 24;10:192. Epub 2015 Oct 24.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

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http://dx.doi.org/10.1186/s13000-015-0424-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619363PMC
October 2015

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma.

Oncotarget 2015 Sep;6(28):26079-89

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.4581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694887PMC
September 2015

ITPKA expression is a novel prognostic factor in hepatocellular carcinoma.

Diagn Pathol 2015 Aug 7;10:136. Epub 2015 Aug 7.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Block 2, Room 708, 651 Dongfeng East Road, Guangzhou, 510060, China.

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http://dx.doi.org/10.1186/s13000-015-0374-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528344PMC
August 2015

ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma.

Stem Cell Reports 2015 Jul 18;5(1):45-59. Epub 2015 Jun 18.

Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; State Key Laboratory for Liver Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618447PMC
July 2015

p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.

Int J Cancer 2015 Mar 7;136(6):1361-70. Epub 2014 Aug 7.

School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Department of Anatomy and Center for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/ijc.29114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312942PMC
March 2015

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

J Hepatol 2015 Mar 30;62(3):607-16. Epub 2014 Oct 30.

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.10.029DOI Listing
March 2015

Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets.

PLoS Genet 2015 Feb 18;11(2):e1004873. Epub 2015 Feb 18.

The State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1371/journal.pgen.1004873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334495PMC
February 2015

Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway.

Oncotarget 2014 Nov;5(22):11576-87

Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294385PMC
http://dx.doi.org/10.18632/oncotarget.2596DOI Listing
November 2014

MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma.

Oncotarget 2014 Nov;5(22):11669-80

State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294333PMC
http://dx.doi.org/10.18632/oncotarget.2581DOI Listing
November 2014

The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update.

Protein Cell 2014 Sep 11;5(9):673-91. Epub 2014 Jun 11.

Department of Clinical Oncology, University of Hong Kong, Hong Kong, China.

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http://link.springer.com/10.1007/s13238-014-0065-9
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http://dx.doi.org/10.1007/s13238-014-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145080PMC
September 2014

Podoplanin‑positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion.

Mol Med Rep 2014 Sep 17;10(3):1513-8. Epub 2014 Jun 17.

State Key Laboratory of Oncology in Southern China, Sun Yat‑Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.

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http://dx.doi.org/10.3892/mmr.2014.2338DOI Listing
September 2014

CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma.

Oncotarget 2014 Sep;5(17):7663-76

Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, CUHK Shenzhen Research Institute, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202152PMC
http://dx.doi.org/10.18632/oncotarget.2288DOI Listing
September 2014

Enhancement of cisplatin-based TACE by a hemoglobin-based oxygen carrier in an orthotopic rat HCC model.

Artif Cells Nanomed Biotechnol 2014 Aug 25;42(4):229-36. Epub 2013 Jun 25.

Department of Surgery, the Hong Kong University , Hong Kong.

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http://dx.doi.org/10.3109/21691401.2013.808647DOI Listing
August 2014

Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression.

Oncotarget 2014 Aug;5(16):6716-33

State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Sun Yat-sen University Cancer Center, Guangzhou, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196158PMC
http://dx.doi.org/10.18632/oncotarget.2236DOI Listing
August 2014

miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis.

Mol Cancer 2014 Aug 7;13:184. Epub 2014 Aug 7.

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-13-184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127521PMC
August 2014

High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma.

Int J Clin Exp Pathol 2013 15;6(11):2497-505. Epub 2013 Oct 15.

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center Guangzhou, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816819PMC
July 2014

Roles of eukaryotic initiation factor 5A2 in human cancer.

Int J Biol Sci 2013 12;9(10):1013-20. Epub 2013 Oct 12.

1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China. Collaborative Innovation Center of Cancer Medicine.

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http://dx.doi.org/10.7150/ijbs.7191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831114PMC
July 2014

Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133.

Oncotarget 2014 Jul;5(14):5725-35

Department of Anatomy, The University of Hong Kong, Hong Kong. State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong. Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170635PMC
http://dx.doi.org/10.18632/oncotarget.2167DOI Listing
July 2014

Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.

Gastroenterology 2014 Jun 21;146(7):1701-13.e9. Epub 2014 Feb 21.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140024
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http://dx.doi.org/10.1053/j.gastro.2014.02.029DOI Listing
June 2014

Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.

Carcinogenesis 2014 May 7;35(5):1154-61. Epub 2014 Feb 7.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

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http://carcin.oxfordjournals.org/content/early/2014/03/06/ca
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu040DOI Listing
May 2014

Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.

Gastroenterology 2014 Apr 11;146(4):1084-96. Epub 2014 Jan 11.

Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China; State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085140002
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http://dx.doi.org/10.1053/j.gastro.2013.12.041DOI Listing
April 2014

microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization.

Exp Mol Pathol 2014 Apr 18;96(2):195-9. Epub 2014 Jan 18.

Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.yexmp.2013.11.004DOI Listing
April 2014

Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.

PLoS One 2013 24;8(7):e68838. Epub 2013 Jul 24.

State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068838PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722219PMC
February 2014

Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling.

Hepatology 2014 Feb 23;59(2):531-43. Epub 2013 Dec 23.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.26677DOI Listing
February 2014

Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.

Cancer Res 2014 Feb 3;74(3):840-51. Epub 2013 Dec 3.

Authors' Affiliations: Department of Clinical Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou; State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Centre; Key Laboratory for Major Obstetric Disease of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou; Department of Clinical Oncology, Nanyang city first people's hospital, Henan; Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China; and Cancer Science Institute of Singapore, National University of Singpaore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2545DOI Listing
February 2014

Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma.

Int J Cancer 2013 Nov 13;133(10):2284-95. Epub 2013 Jul 13.

Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1002/ijc.28252DOI Listing
November 2013

Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing.

Int J Biochem Cell Biol 2013 Aug 4;45(8):1843-8. Epub 2013 Jun 4.

Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.biocel.2013.05.033DOI Listing
August 2013

Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma.

Biochem Biophys Res Commun 2013 Jul 17;436(4):711-8. Epub 2013 Jun 17.

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1016/j.bbrc.2013.06.021DOI Listing
July 2013

Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma.

Cancer Res 2013 Apr 22;73(7):2298-309. Epub 2013 Feb 22.

State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2663DOI Listing
April 2013