Publications by authors named "Xin-Ying Jiao"

2 Publications

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Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

Authors:
Li-Dong Wang Fu-You Zhou Xue-Min Li Liang-Dan Sun Xin Song Yan Jin Jiang-Man Li Guo-Qiang Kong Hong Qi Juan Cui Lian-Qun Zhang Jie-Zhi Yang Ji-Lin Li Xing-Chuan Li Jing-Li Ren Zhi-Cai Liu Wen-Jun Gao Ling Yuan Wu Wei Yan-Rui Zhang Wei-Peng Wang Ilyar Sheyhidin Feng Li Bao-Ping Chen Shu-Wei Ren Bin Liu Dan Li Jian-Wei Ku Zong-Min Fan Sheng-Li Zhou Zhi-Gang Guo Xue-Ke Zhao Na Liu Yong-Hong Ai Fang-Fang Shen Wen-Yan Cui Shuang Song Tao Guo Jing Huang Chao Yuan Jia Huang Yue Wu Wen-Bin Yue Chang-Wei Feng Hong-Lei Li Yan Wang Jin-Ya Tian Yue Lu Yi Yuan Wen-Liang Zhu Min Liu Wen-Jing Fu Xia Yang Han-Jing Wang Suo-Li Han Jie Chen Min Han Hai-Yan Wang Peng Zhang Xiu-Min Li Jin-Cheng Dong Guo-Lan Xing Ran Wang Ming Guo Zhi-Wei Chang Hai-Lin Liu Li Guo Zhi-Qing Yuan Hai Liu Qin Lu Liu-Qin Yang Fu-Guo Zhu Xiu-Feng Yang Xiao-Shan Feng Zhou Wang Yin Li She-Gan Gao Qirenwang Qige Long-Tang Bai Wen-Jun Yang Guang-Yan Lei Zhong-Ying Shen Long-Qi Chen En-Min Li Li-Yan Xu Zhi-Yong Wu Wei-Ke Cao Jian-Po Wang Zhi-Qin Bao Ji-Li Chen Guang-Cheng Ding Xiang Zhuang Ying-Fa Zhou Hou-Feng Zheng Zheng Zhang Xian-Bo Zuo Zi-Ming Dong Dong-Mei Fan Xin He Jin Wang Qi Zhou Qin-Xian Zhang Xin-Ying Jiao Shi-Yong Lian Ai-Fang Ji Xiao-Mei Lu Jin-Sheng Wang Fu-Bao Chang Chang-Dong Lu Zhi-Guo Chen Jian-Jun Miao Zeng-Lin Fan Ruo-Bai Lin Tai-Jiang Liu Jin-Chang Wei Qing-Peng Kong Yu Lan Yu-Jing Fan Fu-Sheng Gao Tian-Yun Wang Dong Xie Shu-Qing Chen Wan-Cai Yang Jun-Yan Hong Liang Wang Song-Liang Qiu Zhi-Ming Cai Xue-Jun Zhang

Nat Genet 2010 Sep 22;42(9):759-63. Epub 2010 Aug 22.

Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China.

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.
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http://dx.doi.org/10.1038/ng.648DOI Listing
September 2010

[Dysregulation of Annexin II expression in esophageal squamous cell cancer and adjacent tissues from a high-incidence area for esophageal cancer in Henan province].

Ai Zheng 2007 Jul;26(7):730-6

Henan Provincial Key Laboratory for Esophageal Cancer, Zhengzhou, Henan, 450052, P. R. China.

Background & Objective: Our recent study on proteomics for esophageal cancer has indicated the importance of Annexin II as a promising protein to distinguish esophageal cancer patients from healthy subjects. This study was to detect the expression of Annexin II in esophageal squamous cell carcinoma (ESCC) and adjacent tissues, and to explore the role of Annexin II in ESCC pathogenesis and mechanisms.

Methods: The expression of Annexin I in 33 specimens of ESCC and adjacent tissues from Linzhou, a high-incidence area for esophageal cancer in Henan province, was detected by ABC immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR).

Results: Annexin II protein was expressed in 90.6% normal esophageal epithelium and decreased with ESCC progression. In carcinoma in situ (CIS), 50.0% foci lost Annexin II protein expression. The expression of Annexin II protein was increased in well differentiated SCC and decreased with loss of differentiation of SCC. In poorly differentiated SCC, 45.4% foci lost Annexin II protein expression. However, RT-PCR did not detect differential expression of Annexin II mRNA between normal esophageal epithelium and CIS.

Conclusions: Elevated or reduced expression of Annexin II may be correlated to reverse or progression of carcinogenesis respectively, and Annexin II may be another candidate biomarker for screening of high-risk subjects and early diagnosis of SCC.
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July 2007