Dr. Xin-Hai Pei, PhD - University of Miami Miller School of Medicine - Associate Professor

Dr. Xin-Hai Pei

PhD

University of Miami Miller School of Medicine

Associate Professor

Miami, FL | United States

ORCID logohttps://orcid.org/0000-0001-6441-1691

Dr. Xin-Hai Pei, PhD - University of Miami Miller School of Medicine - Associate Professor

Dr. Xin-Hai Pei

PhD

Introduction

Primary Affiliation: University of Miami Miller School of Medicine - Miami, FL , United States

Publications

41Publications

459Reads

-Profile Views

714PubMed Central Citations

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange.

Mol Cell 2018 08 26;71(4):621-628.e4. Epub 2018 Jul 26.

Department of Biochemistry & Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097932PMC
August 2018
7 Reads
14.020 Impact Factor

Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression.

Breast Cancer Res 2018 07 11;20(1):74. Epub 2018 Jul 11.

Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery, University of Miami, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1186/s13058-018-0996-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042319PMC
July 2018
1 Read

p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.

Oncotarget 2016 Dec;7(51):84496-84507

Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

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http://dx.doi.org/10.18632/oncotarget.13015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356676PMC
December 2016
6 Reads
2 Citations
6.360 Impact Factor

Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.

Oncotarget 2016 Sep;7(39):64007-64020

Molecular Oncology Program, Division of Surgical Oncology, Department of Surgery, Miller School of Medicine, University of Miami, FL 33136, Miami.

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http://dx.doi.org/10.18632/oncotarget.11746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325421PMC
September 2016
22 Reads
3 Citations
6.360 Impact Factor

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.

Cell Death Dis 2016 Mar 10;7:e2131. Epub 2016 Mar 10.

Department of Otolaryngology (D-48), University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/cddis.2016.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823939PMC
March 2016
5.014 Impact Factor

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

PLoS One 2014 8;9(7):e101969. Epub 2014 Jul 8.

Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida, United States of America; Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida, United States of America; Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086981PMC
October 2015
40 Reads
12 Citations
3.234 Impact Factor

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

J Biol Chem 2014 Dec 29;289(51):35494-502. Epub 2014 Oct 29.

From the Molecular Oncology Program, The DeWitt Daughtry Family Department of Surgery and the Sylvester Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136

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http://dx.doi.org/10.1074/jbc.M114.595348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271234PMC
December 2014
36 Reads
22 Citations
4.573 Impact Factor

BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.

Cancer Res 2014 Nov 19;74(21):6161-72. Epub 2014 Sep 19.

Molecular Oncology Program, Department of Surgery and Sylvester Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1119DOI Listing
November 2014
41 Reads
12 Citations
9.330 Impact Factor

Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.

Cancer Res 2014 Nov 27;74(21):6364-74. Epub 2014 Aug 27.

Molecular Oncology Program, DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida. Division of Surgical Oncology, DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527315PMC
November 2014
43 Reads
15 Citations
9.330 Impact Factor

Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Cancer Res 2014 Sep 3;74(17):4811-21. Epub 2014 Jul 3.

Molecular Oncology Program, Department of Surgery, University of Miami, Miami, Florida. Sylvester Cancer Center, University of Miami, Miami, Florida. Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321822PMC
September 2014
34 Reads
13 Citations
9.330 Impact Factor

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.

Sci Signal 2014 Jul 15;7(334):ra67. Epub 2014 Jul 15.

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA. Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/scisignal.2005309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182917PMC
July 2014
36 Reads
10 Citations
6.280 Impact Factor

p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation.

Mol Cell Biol 2014 Jun 31;34(12):2121-34. Epub 2014 Mar 31.

Molecular Oncology Program, Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA

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http://dx.doi.org/10.1128/MCB.01363-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054302PMC
June 2014
15 Reads
8 Citations
4.780 Impact Factor

CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.

Mol Cell 2014 Jun 1;54(5):805-19. Epub 2014 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA; Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172312PMC
June 2014
5 Reads
11 Citations
14.020 Impact Factor

Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation.

Oncogene 2013 May 9;32(22):2715-25. Epub 2012 Jul 9.

Molecular Oncology Program, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/onc.2012.293DOI Listing
May 2013
4 Reads
12 Citations
8.460 Impact Factor

p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb.

Cancer Res 2011 Apr 29;71(7):2781-92. Epub 2011 Mar 29.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227421PMC
April 2011
22 Reads
16 Citations
9.330 Impact Factor

Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis.

Cancer Res 2011 Apr 12;71(8):2969-77. Epub 2011 Apr 12.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088989PMC
April 2011
4 Reads
17 Citations
9.330 Impact Factor

CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.

Cancer Cell 2009 May;15(5):389-401

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699569PMC
May 2009
14 Reads
42 Citations
23.523 Impact Factor

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.

Mol Cell Biol 2008 Apr 28;28(7):2426-36. Epub 2008 Jan 28.

Department of Biological Chemistry, School of Medicine, Molecular and Cellular Biology Laboratory, Institutes of Biomedical Sciences, Department of Biology, School of Life Science, Fudan University, Shanghai 200032, China.

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http://dx.doi.org/10.1128/MCB.01874-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268418PMC
April 2008
13 Reads
270 Citations
4.780 Impact Factor

Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.

Cancer Res 2007 May;67(10):4732-41

Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3437DOI Listing
May 2007
32 Reads
27 Citations
9.330 Impact Factor

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.

Cancer Res 2007 Apr;67(7):3162-70

Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4517DOI Listing
April 2007
7 Reads
19 Citations
9.330 Impact Factor

p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.

Mol Cell Biol 2007 Feb 4;27(4):1495-504. Epub 2006 Dec 4.

Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1128/MCB.01764-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800728PMC
February 2007
18 Reads
16 Citations
4.780 Impact Factor

p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.

Mol Cell Biol 2006 Jun;26(12):4564-76

Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1128/MCB.00266-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489117PMC
June 2006
3 Reads
18 Citations
4.780 Impact Factor

Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues.

Oncogene 2005 Apr;24(17):2787-95

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1038/sj.onc.1208611DOI Listing
April 2005
1 Read
39 Citations
8.460 Impact Factor

Genetic evidence for functional dependency of p18Ink4c on Cdk4.

Mol Cell Biol 2004 Aug;24(15):6653-64

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1128/MCB.24.15.6653-6664.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC444851PMC
August 2004
2 Reads
11 Citations
4.780 Impact Factor

Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.

Teratog Carcinog Mutagen 2003 ;Suppl 1:161-70

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/tcm.10071DOI Listing
September 2003
5 Reads
6 Citations

Haploinsufficiency of p18(INK4c) sensitizes mice to carcinogen-induced tumorigenesis.

Mol Cell Biol 2003 Feb;23(4):1269-77

Lineberger Comprehensive Cancer Center. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141153PMC
http://dx.doi.org/10.1128/mcb.23.4.1269-1277.2003DOI Listing
February 2003
3 Reads
29 Citations
4.780 Impact Factor

Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line.

Cytokine 2002 Sep;19(5):236-41

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan.

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September 2002
1 Read
12 Citations
2.664 Impact Factor

Polychlorinated biphenyls promote 1-nitropyrene-induced lung tumorigenesis without the induction of K-ras gene mutation in A/J mice.

Teratog Carcinog Mutagen 2001 ;21(6):395-403

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/tcm.1027DOI Listing
January 2002
3 Reads
1 Citation

Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21.

Am J Respir Cell Mol Biol 2000 Jun;22(6):747-54

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1165/ajrcmb.22.6.3877DOI Listing
June 2000
8 Citations
3.985 Impact Factor

Analysis of Fas and Fas ligand expression and function in lung cancer cell lines.

Eur J Cancer 2000 Mar;36(5):656-63

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1016/s0959-8049(99)00332-9DOI Listing
March 2000
1 Read
4 Citations
5.420 Impact Factor

Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells.

Cancer Gene Ther 2000 Feb;7(2):300-7

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1038/sj.cgt.7700096DOI Listing
February 2000
12 Reads
6 Citations
2.420 Impact Factor

Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activity.

J Biol Chem 1999 Dec;274(49):35240-6

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1074/jbc.274.49.35240DOI Listing
December 1999
11 Citations
4.573 Impact Factor

Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer.

Oncology 1999 Nov;57(4):318-23

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1159/000012068DOI Listing
November 1999
1 Read
5 Citations
2.422 Impact Factor

[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report].

Fukuoka Igaku Zasshi 1999 May;90(5):231-7

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka.

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May 1999
1 Citation

Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells.

Br J Cancer 1999 Jan;79(1):40-6

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1038/sj.bjc.6690009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362164PMC
January 1999
7 Reads
12 Citations
4.840 Impact Factor

Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice.

Mol Carcinog 1998 Aug;22(4):258-64

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/(sici)1098-2744(199808)22:4<258::aid-mc7>3.0.co;2-fDOI Listing
August 1998
1 Citation
4.810 Impact Factor

G-CSF increases secretion of urokinase-type plasminogen activator by human lung cancer cells.

Clin Exp Metastasis 1998 Aug;16(6):551-8

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1023/a:1006546402703DOI Listing
August 1998
14 Reads
3.491 Impact Factor

The levels of integrin alpha v beta 5 may predict the susceptibility to adenovirus-mediated gene transfer in human lung cancer cells.

Gene Ther 1998 Mar;5(3):361-8

Research Institute for Diseases of the Chest, Kyushu University School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1038/sj.gt.3300608DOI Listing
March 1998
2 Reads
10 Citations
3.104 Impact Factor

Effect of CPT-11 in combination with other anticancer agents in lung cancer cells.

Anticancer Drugs 1997 Mar;8(3):231-7

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1097/00001813-199703000-00003DOI Listing
March 1997
3 Reads
6 Citations
1.891 Impact Factor

Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro.

Clin Exp Metastasis 1996 Sep;14(4):351-7

Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1007/bf00123394DOI Listing
September 1996
1 Read
3 Citations
3.491 Impact Factor

Immunohistochemical expression of glutathione S-transferase-Pi can predict chemotherapy response in patients with nonsmall cell lung carcinoma.

Cancer 1996 Aug;78(3):416-21

Research Instutute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/(SICI)1097-0142(19960801)78:3<416::AID-CNCR6>3.0.CO;2-HDOI Listing
August 1996
4 Citations
4.890 Impact Factor