Publications by authors named "Xin Yuan"

412 Publications

Super-compression of large electron microscopy time series by deep compressive sensing learning.

Patterns (N Y) 2021 Jul 24;2(7):100292. Epub 2021 Jun 24.

Department of Physics and Astronomy, University of California, Irvine, Irvine, CA, USA.

The development of ultrafast detectors for electron microscopy (EM) opens a new door to exploring dynamics of nanomaterials; however, it raises grand challenges for big data processing and storage. Here, we combine deep learning and temporal compressive sensing (TCS) to propose a novel EM big data compression strategy. Specifically, TCS is employed to compress sequential EM images into a single compressed measurement; an end-to-end deep learning network is leveraged to reconstruct the original images. Owing to the significantly improved compression efficiency and built-in denoising capability of the deep learning framework over conventional JPEG compression, compressed videos with a compression ratio of up to 30 can be reconstructed with high fidelity. Using this approach, considerable encoding power, memory, and transmission bandwidth can be saved, allowing it to be deployed to existing detectors. We anticipate the proposed technique will have far-reaching applications in edge computing for EM and other imaging techniques.
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http://dx.doi.org/10.1016/j.patter.2021.100292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276025PMC
July 2021

Androgen receptor splice variant 7 functions independently of the full length receptor in prostate cancer cells.

Cancer Lett 2021 Jul 10. Epub 2021 Jul 10.

Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

One mechanism for reactivation of androgen receptor (AR) activity after androgen deprivation therapy in castration-resistant prostate cancer (CRPC) is expression of splice variants such as ARv7 that delete the ligand binding domain and have constitutive activity. Exogenous overexpressed ARv7 can function as a homodimer or heterodimer with full length AR (ARfl), which is highly expressed with ARv7 in CRPC. However, the extent to which endogenous ARv7 function is dependent on heterodimerization with ARfl remains to be determined. We used double-crosslinking to stabilize AR complexes on chromatin in a CRPC cell line expressing endogenous ARfl and ARv7 (LN95 cells), and established that only trace levels of ARfl were associated with ARv7 on chromatin. Consistent with this result, depletion of ARfl with a PROTAC targeting the AR ligand binding domain did not decrease ARv7 binding to chromatin or its association with HOXB13, but did decrease overall AR transcriptional activity. Comparable results were obtained in CWR22RV1 cells, another CRPC cell line expressing ARfl and ARv7. These results indicate that ARv7 function in CRPC is not dependent on ARfl, and that both contribute independently to overall AR activity.
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http://dx.doi.org/10.1016/j.canlet.2021.07.013DOI Listing
July 2021

Coating matching recommendation based on improved fuzzy comprehensive evaluation and collaborative filtering algorithm.

Sci Rep 2021 Jul 7;11(1):14035. Epub 2021 Jul 7.

School of Mechanical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212100, Jiangsu, China.

Coating matching design is one of the important parts of ship coating process design. The selection of coating matching is influenced by various factors such as marine corrosive environment, anti-corrosion period and working conditions. There are also differences in the coating performance requirements for different ship types and different coating parts. At present, the design of coating matching in shipyards depends on the experience of technologist, which is not conducive to the scientific management of ship painting process and the macro control of ship construction cost. Therefore, this paper proposes a hybrid algorithm of fuzzy comprehensive evaluation and collaborative filtering based on user label improvement (IFCE-CF). Based on the analytic hierarchy process (AHP), the evaluation index system of coating matching is constructed, and the weight calculation process of fuzzy comprehensive evaluation is optimized by introducing the user label weight. The collaborative filtering algorithm based on matrix decomposition is used to realize the accurate recommendation of coating matching. Historical coating process data of a shipyard between 2010 and 2020 are selected to verify the recommendation ability of the method in the paper. The results show that using the coating matching intelligent recommendation algorithm proposed in this paper, the root mean square error is < 1.02 and the mean absolute error is < 0.75, the prediction accuracy is significantly better than other research methods, which proves the effectiveness of the method.
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http://dx.doi.org/10.1038/s41598-021-93628-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263793PMC
July 2021

GapClust is a light-weight approach distinguishing rare cells from voluminous single cell expression profiles.

Nat Commun 2021 07 7;12(1):4197. Epub 2021 Jul 7.

Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Single cell RNA sequencing (scRNA-seq) is a powerful tool in detailing the cellular landscape within complex tissues. Large-scale single cell transcriptomics provide both opportunities and challenges for identifying rare cells playing crucial roles in development and disease. Here, we develop GapClust, a light-weight algorithm to detect rare cell types from ultra-large scRNA-seq datasets with state-of-the-art speed and memory efficiency. Benchmarking on diverse experimental datasets demonstrates the superior performance of GapClust compared to other recently proposed methods. When applying our algorithm to an intestine and 68 k PBMC datasets, GapClust identifies the tuft cells and a previously unrecognised subtype of monocyte, respectively.
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http://dx.doi.org/10.1038/s41467-021-24489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263561PMC
July 2021

Path Planning for Mobile Robot Based on Improved Bat Algorithm.

Sensors (Basel) 2021 Jun 26;21(13). Epub 2021 Jun 26.

College of Intelligent Systems Science and Engineering, Harbin Engineering University, Harbin 150001, China.

Bat algorithm has disadvantages of slow convergence rate, low convergence precision and weak stability. In this paper, we designed an improved bat algorithm with a logarithmic decreasing strategy and Cauchy disturbance. In order to meet the requirements of global optimal and dynamic obstacle avoidance in path planning for a mobile robot, we combined bat algorithm (BA) and dynamic window approach (DWA). An undirected weighted graph is constructed by setting virtual points, which provide path switch strategies for the robot. The simulation results show that the improved bat algorithm is better than the particle swarm optimization algorithm (PSO) and basic bat algorithm in terms of the optimal solution. Hybrid path planning methods can significantly reduce the path length compared with the dynamic window approach. Path switch strategy is proved effective in our simulations.
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http://dx.doi.org/10.3390/s21134389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272107PMC
June 2021

Narrow-Bandgap Single-Component Polymer Solar Cells with Approaching 9% Efficiency.

Adv Mater 2021 Jun 27:e2101295. Epub 2021 Jun 27.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, 199 Ren-Ai Road, Suzhou Industrial Park, Suzhou, 215123, P. R. China.

Two narrow-bandgap block conjugated polymers with a (D1-A1)-(D2-A2) backbone architecture, namely PBDB-T-b-PIDIC2T and PBDB-T-b-PTY6, are designed and synthesized for single-component organic solar cells (SCOSCs). Both polymers contain same donor polymer, PBDB-T, but different polymerized nonfullerene molecule acceptors. Compared to all previously reported materials for SCOSCs, PBDB-T-b-PIDIC2T and PBDB-T-b-PTY6 exhibit narrower bandgap for better light harvesting. When incorporated into SCOSCs, the short-circuit current density (J ) is significantly improved to over 15 mA cm , together with a record-high power conversion efficiency (PCE) of 8.64%. Moreover, these block copolymers exhibit low energy loss due to high charge transfer (CT) states (E ) plus small non-radiative loss (0.26 eV), and improved stability under both ambient condition and continuous 80 °C thermal stresses for over 1000 h. Determination of the charge carrier dynamics and film morphology in these SCOSCs reveals increased carrier recombination, relative to binary bulk-heterojunction devices, which is mainly due to reduced ordering of both donor and acceptor fragments. The close structural relationship between block polymers and their binary counterparts also provides an excellent framework to explore further molecular features that impact the photovoltaic performance and boost the state-of-the-art efficiency of SCOSCs.
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http://dx.doi.org/10.1002/adma.202101295DOI Listing
June 2021

Clinical Analysis of Severe Radiation Pneumonia.

Int J Gen Med 2021 16;14:2581-2588. Epub 2021 Jun 16.

Department of Respiratory Medicine, Strategic Support Force Medical Center, Beijing, 100101, People's Republic of China.

Objective: The present study aims to discuss the clinical characteristics, factors, and treatment methods affecting the prognosis in patients with severe radiation pneumonia (RP).

Methods: The radiotherapy status, clinical features, imaging characteristics, laboratory examination results, treatment methods, and prognoses of 34 patients with severe RP treated in our department between January 2011 and July 2017 were retrospectively analyzed. The severe RP grading was based on the Common Terminology Criteria for Adverse Events version 4.0; patients who scored Grade ≥3 were considered to have a severe case of RP.

Results: The results of the present study showed that 22 patients had lung cancer, 6 had esophageal cancer, 5 had breast cancer, and 1 had colon cancer with lung metastasis. The total radiation dose was 37.5-66 Gy, and the overall average dose was 53 Gy; the average dose in the patients who died was 52.9 Gy. A total of 28 patients presented with a cough and sputum as the initial symptom, and 24 presented with wheezing as an accompanying symptom; of the 24 patients, 8 experienced fever, 2 experienced wheezing as the only symptom, 1 had chest pain, and 1 had chest tightness. In 26 patients, the changes were in the radiation field, and in 8 cases, the changes appeared both inside and outside the radiation field. After the use of glucocorticoid methylprednisolone, respiratory support, and anti-infection treatment, 18 patients were cured, 8 showed a condition improvement, and 8 died.

Conclusion: The prognosis of severe RP was not significantly correlated with the administered radiation dose; however, lung cancer, a high Acute Physiology and Chronic Health Evaluation score, and delayed diagnosis were risk factors for patient death. However, a combination of antibiotic therapy, ventilator-assisted respiration, and steroid therapy could improve patient prognosis.
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http://dx.doi.org/10.2147/IJGM.S311569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216199PMC
June 2021

Nonconvex Structural Sparsity Residual Constraint for Image Restoration.

IEEE Trans Cybern 2021 Jun 23;PP. Epub 2021 Jun 23.

This article proposes a novel nonconvex structural sparsity residual constraint (NSSRC) model for image restoration, which integrates structural sparse representation (SSR) with nonconvex sparsity residual constraint (NC-SRC). Although SSR itself is powerful for image restoration by combining the local sparsity and nonlocal self-similarity in natural images, in this work, we explicitly incorporate the novel NC-SRC prior into SSR. Our proposed approach provides more effective sparse modeling for natural images by applying a more flexible sparse representation scheme, leading to high-quality restored images. Moreover, an alternating minimizing framework is developed to solve the proposed NSSRC-based image restoration problems. Extensive experimental results on image denoising and image deblocking validate that the proposed NSSRC achieves better results than many popular or state-of-the-art methods over several publicly available datasets.
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http://dx.doi.org/10.1109/TCYB.2021.3084931DOI Listing
June 2021

AcWRKY40 mediates ethylene biosynthesis during postharvest ripening in kiwifruit.

Plant Sci 2021 Aug 21;309:110948. Epub 2021 May 21.

Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China; Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits and Vegetables, Collaborative Innovation Center of Postharvest Key Technology and Quality Safety of Fruits and Vegetables, Jiangxi Agricultural University, Nanchang, 330045, China; College of Materials and Chemical Engineering, Pingxiang University, Pingxiang, 330075, China. Electronic address:

WRKY transcription factors belong to a superfamily that is involved in many important biological processes, including plant development and senescence. However, little is known about the transcriptional regulation mechanisms of WRKY genes involved in kiwifruit postharvest ripening. Here, we isolated a WRKY gene from the kiwifruit genome and named it AcWRKY40. AcWRKY40 is a nucleus-localized protein that possesses transcriptional activation activity. The expression of AcWRKY40 was detected, and the gene responded to ethylene treatment during kiwifruit postharvest ripening, indicating its involvement in this process at the transcriptional level. We found multiple cis-acting elements related to maturation and senescence in the AcWRKY40 promoter. GUS activity analysis showed that its promoter activity was induced by exogenous ethylene. Yeast one-hybrid and dual-luciferase assays demonstrated that AcWRKY40 binds to the promoters of AcSAM2, AcACS1, and AcACS2 to activate them. In addition, transient transformations showed that AcWRKY40 enhances the expression of AcSAM2, AcACS1, and AcACS2. Taken together, these results suggest that AcWRKY40 is involved in kiwifruit postharvest ripening, possibly by regulating the expression of genes related to ethylene biosynthesis, thus deepening our understanding of the regulatory mechanisms of WRKY transcription factors in fruit ripening.
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http://dx.doi.org/10.1016/j.plantsci.2021.110948DOI Listing
August 2021

Triply Complementary Priors for Image Restoration.

IEEE Trans Image Process 2021 24;30:5819-5834. Epub 2021 Jun 24.

Recent works that utilized deep models have achieved superior results in various image restoration (IR) applications. Such approach is typically supervised, which requires a corpus of training images with distributions similar to the images to be recovered. On the other hand, the shallow methods, which are usually unsupervised remain promising performance in many inverse problems, e.g., image deblurring and image compressive sensing (CS), as they can effectively leverage nonlocal self-similarity priors of natural images. However, most of such methods are patch-based leading to the restored images with various artifacts due to naive patch aggregation in addition to the slow speed. Using either approach alone usually limits performance and generalizability in IR tasks. In this paper, we propose a joint low-rank and deep (LRD) image model, which contains a pair of triply complementary priors, namely, internal and external, shallow and deep, and non-local and local priors. We then propose a novel hybrid plug-and-play (H-PnP) framework based on the LRD model for IR. Following this, a simple yet effective algorithm is developed to solve the proposed H-PnP based IR problems. Extensive experimental results on several representative IR tasks, including image deblurring, image CS and image deblocking, demonstrate that the proposed H-PnP algorithm achieves favorable performance compared to many popular or state-of-the-art IR methods in terms of both objective and visual perception.
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http://dx.doi.org/10.1109/TIP.2021.3086049DOI Listing
June 2021

Effect of the rapid increase of salinity on anoxic-oxic biofilm reactor for treatment of high-salt and high-ammonia-nitrogen wastewater.

Bioresour Technol 2021 Jun 4;337:125363. Epub 2021 Jun 4.

NingboTech University, Ningbo 315000, China; Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.

The washing wastewater from the desulfuration and denitration of power plants has high salt (chloride and sulfate) and ammonia-nitrogen concentrations and is difficult to treat using microbiological methods. A novel anoxic/oxic biofilm process was developed to remove ammonia from wastewater. Three rapid strategies (sulfate concentration was increased from 0 to 60 g/L in 6, 13, and 22 days (R1, R2, and R3, respectively)) were applied and produced biofilm with the same nitrification capacity as slow strategies (100-203 days). Excessive organics inhibited the nitrification capacity of the biofilm. R1 excelled at ammonia removal (from 30% to 95%, 70 mg/(L·d), with an effluent ammonia concentration of 4 mg/L) at 60 g/L salinity after the organic load was reduced. The content of extracellular polymeric substances in biofilm depended on its capacity to remove organics. Pseudomonas and Thauera were enriched in the three reactors. Controlling the organic load might prevent the sulfur cycle.
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http://dx.doi.org/10.1016/j.biortech.2021.125363DOI Listing
June 2021

Effect of Osteoporosis on Adjacent Segmental Degeneration After Posterior Lumbar Interbody Fusion Under Whole Body Vibration.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

School of Chinese Medicine, Jinan University, Guangzhou, China. Electronic address:

Background: Adjacent segmental degeneration (ASD) is one of the common complications after posterior lumbar interbody fusion (PLIF). Both whole body vibration (WBV) and osteoporosis are important factors associated with the biomechanics of the lumbar spine. However, to the best of our knowledge, no studies have investigated the effects of osteoporosis on ASD after PLIF under WBV.

Methods: In the present study, using one normal model, one PLIF model and one PLIF with osteoporosis model of the L1-S1 segment were developed. A 5-Hz, 40-N sinusoidal vertical load was imposed on the superior surface of L1 of each model to simulate WBV, and the dynamic responses and maximal values of intradiscal pressure, shear stress on annulus fibrosus, total deformation, and disc bulge were evaluated in the L1-L2, L2-L3, L3-L4, and L5-S1 segments.

Results: At the L1-L2, L2-L3, and L3-L4 levels, the differences in the dynamic responses and maximal values in intradiscal pressure, shear stress, total deformation, and disc bulge between the PLIF and PLIF with osteoporosis models were slight. However, at the L5-S1 level, the dynamic response curves and maximal intradiscal pressure, shear stress, and disc bulge values in the PLIF with osteoporosis model were significantly lower than those in the PLIF model.

Conclusions: Osteoporosis can mitigate the development of ASD in the lower adjacent segment but has no obvious influence on the upper adjacent segments during WBV.
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http://dx.doi.org/10.1016/j.wneu.2021.06.031DOI Listing
June 2021

Tbx18-positive cells-derived myofibroblasts contribute to renal interstitial fibrosis via transforming growth factor-β signaling.

Exp Cell Res 2021 Jun 10;405(2):112682. Epub 2021 Jun 10.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

It has been demonstrated that the T-box family transcription factor 18 (Tbx18) -positive cells give rise to renal mesenchymal cells and contribute to the development of the urinary system. However, it is unclear whether Tbx18-positive cells are the origin of the myofibroblasts during renal fibrosis. The present study aimed to determine the contribution of Tbx18-positive cells in kidney fibrosis and their underlying mechanism. We show that Tbx18-positive cells contribute to the development of the urinary system, especially renal fibroblasts. Following unilateral ureteral obstruction (UUO), genetic fate tracing results demonstrated that Tbx18-positive cells not only proliferate but also expand and differentiate into fibroblasts and myofibroblasts, indicating that they may act as profibrotic progenitors. Cell culture results suggest that transforming growth factor (TGF)-β promotes Tbx18-positive cells differentiation into myofibroblasts and assist their contribution to kidney fibrosis. Overall, the present study demonstrated that Tbx18-positive cells may act as profibrotic progenitor cells in a pathological condition of UUO-induced injury. Moreover, TGF-β may play a role in differentiation of Tbx18-positive cells into myofibroblasts in kidney fibrosis. These findings may provide a potential target on Tbx18-positive myofibroblast progenitors in the treatment of renal fibrosis.
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http://dx.doi.org/10.1016/j.yexcr.2021.112682DOI Listing
June 2021

The relationship between the level of vitamin D and ruptured intracranial aneurysms.

Sci Rep 2021 Jun 4;11(1):11881. Epub 2021 Jun 4.

Department of Neurointervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

The purpose of our research is to explore whether vitamin D levels were associated with the rupture of intracranial aneurysms. In this retrospective study, 105 patients diagnosed with ruptured intracranial aneurysms (RIAs) and 185 patients diagnosed with unruptured intracranial aneurysms (UIAs) at The First Affiliated Hospital of Zhengzhou University were recruited from September 2019 to September 2020. Patients' demographic and clinical information, including vitamin D levels, were recorded and compared. Univariate analysis showed that patients with UIAs had higher vitamin D levels than RIAs (p = 0.019). In addition, there were significant differences in aneurysm location (p < 0.001), aspirin use (p = 0.001), and comorbid diabetes mellitus (p = 0.037) between patients with UIAs and RIAs. Binary logistic regression analysis showed that the level of vitamin D was independently associated with RIAs [odds ratio (OR) 0.960; 95% confidence intervals (CI), 0.926-0.996, p = 0.028].
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http://dx.doi.org/10.1038/s41598-021-90760-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178395PMC
June 2021

MD-UNET: Multi-input dilated U-shape neural network for segmentation of bladder cancer.

Comput Biol Chem 2021 May 20;93:107510. Epub 2021 May 20.

School of Information Science and Engineering, Shandong Normal University, Jinan, 250014, China. Electronic address:

Accurate segmentation of the tumour area is crucial for the treatment and prognosis of patients with bladder cancer. However, the complex information from the MRI image poses an important challenge for us to accurately segment the lesion, for example, the high distinction among people, size of bladder variation and noise interference. Based on the above issues, we propose an MD-Unet network structure, which uses multi-scale images as the input of the network, and combines max-pooling with dilated convolution to increase the receptive field of the convolutional network. The results show that the proposed network can obtain higher precision than the existing models for the bladder cancer dataset. The MD-Unet can achieve state-of-art performance compared with other methods.
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http://dx.doi.org/10.1016/j.compbiolchem.2021.107510DOI Listing
May 2021

Lipidomics profiling of goose granulosa cell model of stearoyl-CoA desaturase function identifies a pattern of lipid droplets associated with follicle development.

Cell Biosci 2021 May 22;11(1):95. Epub 2021 May 22.

Country Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, People's Republic of China.

Background: Despite their important functions and nearly ubiquitous presence in cells, an understanding of the biology of intracellular lipid droplets (LDs) in goose follicle development remains limited. An integrated study of lipidomic and transcriptomic analyses was performed in a cellular model of stearoyl-CoA desaturase (SCD) function, to determine the effects of intracellular LDs on follicle development in geese.

Results: Numerous internalized LDs, which were generally spherical in shape, were dispersed throughout the cytoplasm of granulosa cells (GCs), as determined using confocal microscopy analysis, with altered SCD expression affecting LD content. GC lipidomic profiling showed that the majority of the differentially abundant lipid classes were glycerophospholipids, including PA, PC, PE, PG, PI, and PS, and glycerolipids, including DG and TG, which enriched glycerophospholipid, sphingolipid, and glycerolipid metabolisms. Furthermore, transcriptomics identified differentially expressed genes (DEGs), some of which were assigned to lipid-related Gene Ontology slim terms. More DEGs were assigned in the SCD-knockdown group than in the SCD-overexpression group. Integration of the significant differentially expressed genes and lipids based on pathway enrichment analysis identified potentially targetable pathways related to glycerolipid/glycerophospholipid metabolism.

Conclusions: This study demonstrated the importance of lipids in understanding follicle development, thus providing a potential foundation to decipher the underlying mechanisms of lipid-mediated follicle development.
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http://dx.doi.org/10.1186/s13578-021-00604-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141238PMC
May 2021

Image Restoration via Reconciliation of Group Sparsity and Low-Rank Models.

IEEE Trans Image Process 2021 25;30:5223-5238. Epub 2021 May 25.

Image nonlocal self-similarity (NSS) property has been widely exploited via various sparsity models such as joint sparsity (JS) and group sparse coding (GSC). However, the existing NSS-based sparsity models are either too restrictive, e.g., JS enforces the sparse codes to share the same support, or too general, e.g., GSC imposes only plain sparsity on the group coefficients, which limit their effectiveness for modeling real images. In this paper, we propose a novel NSS-based sparsity model, namely, low-rank regularized group sparse coding (LR-GSC), to bridge the gap between the popular GSC and JS. The proposed LR-GSC model simultaneously exploits the sparsity and low-rankness of the dictionary-domain coefficients for each group of similar patches. An alternating minimization with an adaptive adjusted parameter strategy is developed to solve the proposed optimization problem for different image restoration tasks, including image denoising, image deblocking, image inpainting, and image compressive sensing. Extensive experimental results demonstrate that the proposed LR-GSC algorithm outperforms many popular or state-of-the-art methods in terms of objective and perceptual metrics.
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http://dx.doi.org/10.1109/TIP.2021.3078329DOI Listing
May 2021

Screening of the college students at clinical high risk for psychosis in China: a multicenter epidemiological study.

BMC Psychiatry 2021 05 17;21(1):253. Epub 2021 May 17.

Department of Psychiatry, Tongji Hospital of Tongji University, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, PR China.

Background: To investigate a 3-stage screening procedure and explore the clinical features of subjects at Clinical High Risk (CHR) for psychosis in a representative sample of Chinese college students.

Methods: An epidemiological survey of the prevalence of the CHR syndrome in Chinese college students that was selected by stratified random sampling from Shanghai, Nanjing and Nanchang cities was done following a 3-stage procedure. Participants were initially screened with the Prodromal Questionnaire-brief version (PQ-B), and whose distress score of PQ-B exceeded 24 would be invited to a telephone assessment using the subscale for positive symptoms of the Scale of Prodromal Symptoms (SOPS)/Structured Interview for Prodromal Syndromes (SIPS). Lastly, participants who scored 3 or higher in any item of the subscale would be administered with the SIPS interview conducted by trained researchers to confirm the diagnosis of CHR syndrome.

Results: Twenty-three thousand sixty-three college students completed the survey during September 2017 to October 2018. Seventy-two students were diagnosed as CHR subjects, and the detection rate in the total sample was 0.3%. The peak age range for the first diagnosis of CHR was 17 to 20 years. Thirteen and forty-six were set as the cutoff points of PQ-B total score and distress score to balance the greatest sensitivity and specificity. Binary logistic regression revealed that 8 items in PQ-B showed significant distinction for detecting CHR subjects.

Conclusions: The 3-stage screening method can be utilized in the detection of CHR subjects for psychosis in the general population, during which delusional ideas, perceptual abnormalities and suspiciousness deserve great attention.
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http://dx.doi.org/10.1186/s12888-021-03229-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127262PMC
May 2021

Laparoscopic repair of giant hiatal hernia for elderly patients.

Ann Transl Med 2021 Apr;9(8):704

Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Giant hiatal hernias are more common in older patients and can significantly reduce their quality of life. However, open surgery for patients of advanced age is thought to be associated with high morbidity and mortality. The aim of this retrospective study was to evaluate the safety of laparoscopic giant hiatal hernia repair for elderly patients as compared to younger patients.

Methods: From January 2015 to January 2020, 152 consecutive patients underwent laparoscopic mesh repair of giant hiatal hernia. Two cases of missing follow up were excluded. Patients were divided into an elderly group (N=62, age ≥75) and a younger group (N=88, age <75). Interrupted non-absorbable suture was applied for crus closure and as an additional reinforcement, the mesh was fixed with absorbable tacks or medical glue. Procedure-related complications, score-based variation tendency of symptoms, gastrointestinal quality of life index (GIQLI), mortality, recurrence rate, hemoglobin, and the use of PPI were investigated.

Results: All patients underwent the procedure uneventfully. Dor fundoplication was used in 39 patients (62.9%) in the elderly group and 44 (50.0%) in the younger group and no case was converted to open. While the elderly group had a significantly higher percentage of ASA Class level 3 and cardiovascular and cerebrovascular diseases as compared to the younger group, the two groups had similar operative times, intraoperative blood loss, and percentage of intrathoracic stomach. Elderly group patients tended to have higher perioperative complications including pneumonia (3.2%) and atelectasis (3.2%) without statistical significance, as well as transfer to the intensive care unit compared, to younger patients (9.7% . 3.2%; P=0.144). The mean post-operative hospital stay was also significantly shorter in the younger group (2.8 days) compared with the elderly group (3.5 days; P=0.001). There was no mortality, recurrence, mesh-related complications such as visceral erosion, adhesion, or severe dysphagia during follow up in the two groups, and both groups demonstrated significant improvement in GIQLI scores and hemoglobin. The percentage of patients who needed PPI was also reduced in both groups.

Conclusions: Laparoscopic mesh repair of giant hiatal hernia for elderly patients is safe and effective when performed at experienced centers.
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http://dx.doi.org/10.21037/atm-21-1495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106099PMC
April 2021

Comparison of Clinical Efficacy of Neoadjuvant Chemoradiation Therapy Between Lower and Higher Radiation Doses for Carcinoma of the Esophagus and Gastroesophageal Junction: A Systematic Review.

Int J Radiat Oncol Biol Phys 2021 May 6. Epub 2021 May 6.

Department of Radio-Chemotherapy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou City, Jiangsu Province, China. Electronic address:

Purpose: Neoadjuvant concurrent chemoradiation therapy (nCRT) plus surgery has been a standard treatment for locoregionally advanced esophageal cancer and carcinoma of the gastroesophageal junction (EC/GEJ), but the optimal preoperative radiation dose is still unclear. We performed this systematic review to explore the treatment efficacy and toxicity of different radiation dose levels and find an optimal dose-fractionation strategy in EC/GEJ patients receiving nCRT.

Methods And Materials: Embase and Ovid Medline were searched for articles involving cases of operable squamous and adenocarcinoma of the esophagus and GEJ in which patients received nCRT up to a dose of 50.4 Gy in 28 fractions that were published until July 2019, when the search was performed. Physical dose distributions were converted to biologically equivalent doses (BEDs), which were described in units of gray (alpha/beta). Pooled rates of overall survival (OS), progression-free survival (PFS), failure patterns, and toxicities were compared between lower-dose radiation therapy (LDRT; BED ≤48.85 Gy) and higher-dose radiation therapy (HDRT; BED >48.85 Gy) for patients treated with nCRT.

Results: A total of 110 studies with 7577 EC/GEJ patients receiving nCRT were included in this pooled analysis. Both the PFS and OS rates of patients receiving LDRT were significantly higher than those of patients receiving HDRT. Patients receiving LDRT had improved safety regarding treatment-related adverse events and lower distant failure rates than patients receiving HDRT. Utilization of modern radiation therapy (RT) techniques, including 3-dimensional conformal RT and intensity modulated RT, was associated with improved oncologic outcomes compared with 2-dimensional methods. Subgroup analysis showed that EC/GEJ patients receiving conventionally fractionated radiation to a dose of 40.0 to 41.4 Gy in 20-23 fractions showed improved OS compared with those receiving radiation above this dose.

Conclusions: Based on the limited data, nCRT using BED ≤48.85 Gy was suitable for locoregionally advanced, resectable EC/GEJ. A total dose of 40.0 to 41.4 Gy in 20 to 23 fractions using modern RT techniques might provide the optimal therapeutic ratio.
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http://dx.doi.org/10.1016/j.ijrobp.2021.04.031DOI Listing
May 2021

Interleukin-12 exacerbates symptoms in an MRL/MpJ-Faslpr mouse model of systemic lupus erythematosus.

Exp Ther Med 2021 Jun 15;21(6):627. Epub 2021 Apr 15.

Institute of Acute Disorders of Traditional Chinese Internal Medicine, The First Clinical College of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Interleukin (IL)-12 modulates the generation and function of a variety of immune cells and serves an important role in the pathogenesis of autoimmune diseases. However, the precise role of IL-12 in the pathogenesis of systemic lupus erythematosus (SLE) remains to be elucidated. In the present study, the serum levels of IL-12 in patients with SLE were determined using an ELISA. The association between serum levels of IL-12 and clinical and laboratory indices, specifically, disease activity and complement 3, were analyzed. Recombinant IL-12 or an anti-IL-12 antibody was used to treat the MRL/MpJ-Fas mouse model of systemic lupus erythematosus. The glomerulonephritis and inflammatory cell infiltration was examined to evaluate histological changes using hematoxylin and eosin and Periodic acid-Schiff staining. Serum creatinine and proteinuria were used to determine renal function. The levels of anti-double stranded DNA and anti-nuclear autoantibodies were assessed. The results demonstrated that serum levels of IL-12 were markedly increased in patients with SLE compared with controls and in lupus model mice in comparison with control mice. The serum levels of IL-12 increased with disease severity in patients with SLE. SLE-like symptoms were exacerbated in lupus model mice treated with exogenous IL-12. However, SLE-like symptoms were ameliorated in lupus model mice treated with an anti-IL-12 antibody. The present results demonstrated that IL-12 aggravated SLE and anti-IL12 antibodies ameliorated SLE. The present data suggest that blocking IL-12 may be a beneficial therapeutic strategy to halt the progression of lupus nephritis.
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http://dx.doi.org/10.3892/etm.2021.10059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082580PMC
June 2021

Relationship Between Cognitive Fusion, Experiential Avoidance, and Obsessive-Compulsive Symptoms in Patients With Obsessive-Compulsive Disorder.

Front Psychol 2021 12;12:655154. Epub 2021 Apr 12.

Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.

This study aimed to explore the relationship among cognitive fusion, experiential avoidance, and obsessive-compulsive symptoms in patients with obsessive-compulsive disorder (OCD). A total of 118 outpatient and inpatient patients with OCD and 109 healthy participants, gender- and age-matched, were selected using cognitive fusion questionnaire (CFQ), acceptance and action questionnaire-2nd edition (AAQ-II), Yale-Brown scale for obsessive-compulsive symptoms, Hamilton anxiety scale, and Hamilton depression scale for questionnaire testing and data analysis. The levels of cognitive fusion and experiential avoidance in the OCD group were significantly higher than those in the healthy control group ( < 0.05). Regression analysis results showed that, in predicting the total score of obsessive-compulsive symptoms, AAQ-II ( = 0.233, < 0.05) and CFQ ( = 0.262, < 0.01) entered the equation, which explained 17.1% variance. In predicting anxiety, only AAQ-II ( = 0.222, < 0.05) entered the equation, which explained 13% variance. In the prediction of depression, AAQ-II ( = 0.412, < 0.001) entered the equation, which explained 17.7% variance. Cognitive fusion and experiential avoidance may be important factors for the maintenance of OCD, and experiential avoidance can positively predict the anxiety and depression of OCD patients.
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http://dx.doi.org/10.3389/fpsyg.2021.655154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072044PMC
April 2021

Small nucleolar RNA host gene 8: A rising star in the targets for cancer therapy.

Biomed Pharmacother 2021 Jul 21;139:111622. Epub 2021 Apr 21.

Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Long non-coding RNAs (lncRNAs) are a group of transcripts that have been considered essential participants in cancer pathogenesis and progression over the past few decades. Small nucleolar RNA host gene 8 (SNHG8) is a newly discovered lncRNA that belongs to the SNHG family, a group of transcripts that can be processed into small nucleolar RNAs and exert important biological functions. As an oncogenic factor, SNHG8 is upregulated in multiple cancer types. Herein, we summarize the biological role of SNHG8 in different cancer types and the underlying mechanisms related to the interaction between SNHG8 and microRNAs, mRNAs, and proteins. In addition, this study emphasizes the clinical value of SNHG8 in cancer, hoping to provide new insights into cancer diagnosis, prognosis, and treatment.
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http://dx.doi.org/10.1016/j.biopha.2021.111622DOI Listing
July 2021

Snapshot temporal compressive microscopy using an iterative algorithm with untrained neural networks.

Opt Lett 2021 Apr;46(8):1888-1891

We report a snapshot temporal compressive microscopy imaging system, using the idea of video compressive sensing, to capture high-speed microscopic scenes with a low-speed camera. An untrained deep neural network is used in our iterative inversion algorithm to reconstruct 20 high-speed video frames from a single compressed measurement. Specifically, using a camera working at 50 frames per second (fps) to capture the measurement, we can recover videos at 1000 fps. Our deep neural network is embedded in the inversion algorithm, and its parameters are learned simultaneously with the reconstruction.
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http://dx.doi.org/10.1364/OL.420139DOI Listing
April 2021

Snapshot temporal compressive microscopy using an iterative algorithm with untrained neural networks.

Opt Lett 2021 Apr;46(8):1888-1891

We report a snapshot temporal compressive microscopy imaging system, using the idea of video compressive sensing, to capture high-speed microscopic scenes with a low-speed camera. An untrained deep neural network is used in our iterative inversion algorithm to reconstruct 20 high-speed video frames from a single compressed measurement. Specifically, using a camera working at 50 frames per second (fps) to capture the measurement, we can recover videos at 1000 fps. Our deep neural network is embedded in the inversion algorithm, and its parameters are learned simultaneously with the reconstruction.
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http://dx.doi.org/10.1364/OL.420139DOI Listing
April 2021

LED-based compressive spectral-temporal imaging.

Opt Express 2021 Mar;29(7):10698-10715

A compressive spectral-temporal imaging system is reported. A multi-spectral light-emitting diode array is used for target illumination and spectral modulation, while a digital micro-mirror device (DMD) encodes the spatial and temporal frames. Several encoded video frames are captured in a snapshot of an integrating focal plane array (FPA). A high-frame-rate spectral video is reconstructed from the sequence of compressed measurements captured by the grayscale low-frame-rate camera. The imaging system is optimized through the design of the DMD patterns based on the forward model. Laboratory implementation is conducted to validate the performance of the proposed imaging system. We experimentally demonstrate the video acquisition with eight spectral bands and six temporal frames per FPA snapshot, and thus a 256 × 256 × 8 × 6 4D cube is reconstructed from a single 2D measurement.
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http://dx.doi.org/10.1364/OE.419888DOI Listing
March 2021

Gut Microbiota of Chinese Obese Children and Adolescents With and Without Insulin Resistance.

Front Endocrinol (Lausanne) 2021 19;12:636272. Epub 2021 Mar 19.

Division of Pediatric Endocrinology and Diabetes, University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: The intestinal flora of gut microbiota in obese Chinese children and adolescents with and without insulin resistance (IR) was analyzed, as well as associations between the gut microbiota and two serum cytokines related to glucose metabolism, adropin and angiopoietin-like 4 (ANGPTL4).

Methods: Clinical data, fecal bacterial composition, glucose-related hormones, and serum adipokines (adropin and ANGPTL4) were analyzed in 65 Chinese children with exogenous obesity. The composition of the gut microbiota was determined by 16S rRNA-based metagenomics and IR was calculated using the homeostasis model assessment (HOMA).

Results: The 65 obese subjects were divided into two groups: insulin sensitive (IS) (n=40, 57.5% males) or IR (n=25, 60% males). Principal coordinates analysis revealed that the gut microbiota samples from the IS group clustered together and separated partly from the IR group (p=0.008). By Mann-Whitney -test, at a phylum level, a reduction of and an increase of in the IR subjects was observed. LEfSe analysis revealed that IS subject, when compared to their IR counterparts, harbored members of the order , , and family , that were significantly more abundant. In contrast, the IR subjects had members of family that were significantly more prevalent than the IS subjects (all <0.05). Spearman's correlation analysis revealed that serum ANGPTL4 was positively associated with genus , and , and adropin was positively associated with genus and , and negatively associated with genus (all p<0.05).

Conclusion: In obese children, the gut microbiome in IR subjects was significantly discordant from the IS subjects, and the abundance of some metabolism-related bacteria correlated with the serum concentrations of adropin and ANGPTL4. These observations infer that the gut microbiota may be involved in the regulation of glucose metabolism in obesity.
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http://dx.doi.org/10.3389/fendo.2021.636272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018175PMC
March 2021

Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(13):e24519

Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang, China.

Objectives: This meta-analysis was designed to systematically evaluate whether autologous cytokine-induced killer cells (CIK) or dendritic cells and cytokine-induced killer cells (DC-CIK) immunotherapy combined with chemotherapy can improve the therapeutic effect and safety of chemotherapy in esophageal cancer (EC).

Materials And Methods: Randomized controlled trials (RCTs) were electronically searched databases including CNKI, WanFang, WeiPu, CBMDisc, PubMed, Web of Science, EMbase, the Cochrane Library, and Clinical Trials. The databases were searched for articles published until June 2019. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included literature. Meta-analysis was performed using RevMan5.3.

Results: Seventeen studies (1416 participants) were included. The differences between CIK/DC-CIK combination chemotherapy and chemotherapy alone were significant. The results displayed that the number of CD3+, CD4+, CD4+/CD8+, and NK cells was significantly increased after 1 to 2 weeks of treatment with CIK/DC-CIK cells in the treatment group (all P < .05). In addition, the results shown that 1-year overall survival was significantly prolonged (P < .0001) and quality of life was improved (P = .001) in EC chemotherapy combined with immunotherapy groups compared with conventional treatment. Furthermore, cytokine expression levels of interleukin 2 (IL-2), tumor necrosis factor α (TNF-α), and interleukin 12 (IL-12) were significantly increased (P = .0003) as well as the levels of immunoglobulins were elevated (P < .00001). Serum levels of tumor marker molecules, carcinoembryonic antigen (CEA), carbohydrate antigen (CA)-199, and CA-125 were lower in treatment groups than that of control groups (P < .00001). No fatal adverse reactions were noted (P = .04).

Conclusions: It is safe and effective for patients to use chemotherapy combined with CIK/DC-CIK immunotherapy. Immunotherapy can simultaneously improve the antitumor immune response. Specifically, DC-CIK cells can increase T lymphocyte subsets, CIK cells, NK cells, and immunoglobulins in peripheral blood to enhance antitumor immunity. Therefore, combination therapy enhances the immune function and improves the therapeutic efficacy of patients with EC.
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http://dx.doi.org/10.1097/MD.0000000000024519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021386PMC
April 2021

Laparoscopic fixation of biological mesh at hiatus with glue and suture during hiatal hernia repair.

BMC Surg 2021 Mar 22;21(1):158. Epub 2021 Mar 22.

Department of Hernia and Abdominal Wall Surgery, The Capital Medical University Beijing Chaoyang Hospital, Jingyuan Road No.5, Shijingshan District, Beijing, 100043, China.

Background: Laparoscopic paraesophageal hernia repair is associated with higher recurrence rate. Mesh is used to reduce the recurrence rate. This retrospective study is to review our experience of biological mesh fixed with suture and medical glue in hiatal hernias repairs.

Methods: A retrospective chart review was conducted for a consecutive series of patients undergoing laparoscopic hiatal herniorrhaphy between January 2018 and January 2019. After hiatus closure, a piece of biological prosthesis was fixed with medical glue and suture for reinforcement of the crural closure. Clinical outcomes were reviewed, and data were collected regarding operative details, complications, symptoms, and follow-up imaging. Radiological evidence of any size of hiatal hernia was considered to indicate a recurrence.

Results: Thirty-six patients underwent surgery uneventfully without any serious complication. There was no mortality. The follow-up was, on average, 18.4 months, and there was no symptomatic recurrence. There was one anatomical recurrence without any related presentation. The method of mesh fixation with medical glue and suture took 12 min on average, and the handling was fairly easy.

Conclusions: Biological mesh fixed with suture and medical glue was safe and effective for repairing large hiatal hernias. Of course, a longer follow-up is still needed for determining long-term outcomes.
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http://dx.doi.org/10.1186/s12893-021-01151-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983393PMC
March 2021

Electrochemical Tri- and Difluoromethylation-Triggered Cyclization Accompanied by the Oxidative Cleavage of Indole Derivatives.

Chemistry 2021 Apr 10;27(21):6522-6528. Epub 2021 Mar 10.

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S, Nanjing, 211816, P. R. China.

Considering their unique roles in organic synthesis, and pharmaceutical and agrochemical applications, the development of fluoroalkylation, cyclization, and indole oxidative cleavage are important topics. Herein, an unprecedented electrochemical tri- and difluoromethylation/cyclization/indole oxidative cleavage process occurring in an undivided cell is presented. The protocol employs a readily prepared Langlois reagent as the fluoroalkyl source, affording a series of tri- or difluoromethylated 2-(2-acetylphenyl)isoquinoline-1,3-diones in good yields with excellent stereoselectivity. It is worth noting that this new methodology merges the fluoroalkylation/cyclization of N-substituted acrylamide alkenes with the oxidative cleavage of an indole C(2)=C(3) bond under external oxidant-free conditions.
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http://dx.doi.org/10.1002/chem.202005368DOI Listing
April 2021