Publications by authors named "Xin Yu"

1,424 Publications

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Selective electrochemical reduction of carbon dioxide to ethanol a relay catalytic platform.

Chem Sci 2020 Apr 24;11(19):5098-5104. Epub 2020 Apr 24.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 P. R. China

Efficient electroreduction of carbon dioxide (CO) to ethanol is of great importance, but remains a challenge because it involves the transfer of multiple proton-electron pairs and carbon-carbon coupling. Herein, we report a CoO-anchored N-doped carbon material composed of mesoporous carbon (MC) and carbon nanotubes (CNT) as a catalyst for CO electroreduction. The faradaic efficiencies of ethanol and current density reached 60.1% and 5.1 mA cm, respectively. Moreover, the selectivity for ethanol products was extremely high among the products produced from CO. A proposed mechanism is discussed in which the MC-CNT/Co catalyst provides a relay catalytic platform, where CoO catalyzes the formation of CO* intermediates which spill over to MC-CNT for carbon-carbon coupling to form ethanol. The high selectivity for ethanol is attributed mainly to the highly selective carbon-carbon coupling active sites on MC-CNT.
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http://dx.doi.org/10.1039/d0sc01133aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159220PMC
April 2020

Integrative species delimitation based on COI, ITS, and morphological evidence illustrates a unique evolutionary history of the genus (Odonata: Coenagrionidae).

PeerJ 2021 26;9:e11459. Epub 2021 May 26.

Institute of Entomology, College of Life Sciences, Nankai University, Tianjin, China.

are common 'blue and black' colored damselflies. We explore the species boundaries of (Odonata: Coenagrionidae) using ABGD, bPTP, GMYC and Distance-based clustering. We finally got the molecular data of all nine species of . and were combined into one putative species based on cytochrome c oxidase I (COI). However, they were separated into two putative species based on the nuclear segment including ITS1-5.8S-ITS2 (ITS). This suggests the introgression of mtDNA in and can be separated into two species based on COI, whereas they were combined into one putative species based on ITS, which suggests a hybridization event between them. The lower interspecific divergence (COI: 0.49%) between and indicates a recent speciation event in . and can be separated into two putative species based on COI, while they were frequently merged into the same putative species based on ITS. This can be explained by incomplete lineage sorting in nDNA. Besides, and were synonymized as junior synonyms of . was confirmed not to belong to . The possibility of introgression, hybridization, recent speciation and incomplete lineage sorting makes species delimitation, based on molecular data, difficult and complicates understanding of the evolutionary history of . The discordance in COI and ITS also indicates the value of using markers from different sources in species delimitation studies.
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http://dx.doi.org/10.7717/peerj.11459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164416PMC
May 2021

High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

PLoS One 2021 11;16(6):e0253159. Epub 2021 Jun 11.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Participants aged 1-14 years receiving 3HP for TB prevention at Shanghai Public Health Clinical Center were followed from December 2019 to November 2020 to evaluate the safety and completion rate of the treatment. Thirty-one children were eligible for inclusion, but five were excluded from the analysis (three were treated with a lower than recommended dose, and two were lost to follow-up). Of the 26 children included in the analysis, the treatment completion rate was 100%. Adverse drug reactions (ADRs) were reported in 38.5% (10/26) of the patients. The most common ADRs were gastrointestinal symptoms (19.2%,5/26), and all ADRs were rated as Grade 1. The 3HP regimen has a high completion rate, and it seems well tolerated in our study population. However, further randomized controlled clinical trial with larger sample size are warranted.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253159PLOS
June 2021

Anxiety symptom remission is associated with genetic variation of PTPRZ1 among patients with major depressive disorder treated with escitalopram.

Pharmacogenet Genomics 2021 Jun 1. Epub 2021 Jun 1.

Clinical Psychopharmacology Division, Peking University Sixth Hospital & Peking University Institute of Mental Health & Key Laboratory of Mental Health, Ministry of Health (Peking University) & National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, Canada Department of Physiology, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Objectives: Genome-wide analyses of antidepressant response have suggested that genes initially associated with risk for schizophrenia may also serve as promising candidates for selective serotonin reuptake inhibitor (SSRI) efficacy. Protein tyrosine phosphatase, receptor-type, zeta-1 (PTPRZ1) has previously been shown to be associated with schizophrenia, but it has not been investigated as a predictor of antidepressant efficacy. The main objective of the study was to assess whether SSRI-mediated depressive and anxiety symptom remission in Chinese patients with major depressive disorder (MDD) are associated with specific PTPRZ1 variants.

Methods: Two independent cohorts were investigated, the first sample (N = 344) received an SSRI (i.e. fluoxetine, sertraline, citalopram, escitalopram, fluvoxamine, or paroxetine) for 8 weeks. The second sample (N = 160) only received escitalopram for 8 weeks. Hamilton Depression and Hamilton Anxiety Rating Scale scores at 8-weeks post-baseline in both cohorts were used to determine remission status. Five PTPRZ1 variants (rs12154537, rs6466810, rs6466808, rs6955395, and rs1918031) were genotyped in both cohorts.

Results: Anxiety symptom remission was robustly associated with PTPRZ1 rs12154537 (P = 0.004) and the G-G-G-G haplotype (rs12154537-rs6466810-rs6466808-rs6955395; P = 0.005) in cohort 2 but not cohort 1 (mixed SSRI use). Associations with depressive symptom remission did not survive correction for multiple testing.

Conclusions: These findings suggest that PTPRZ1 variants may serve as a marker of escitalopram-mediated anxiety symptom remission in MDD.
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http://dx.doi.org/10.1097/FPC.0000000000000437DOI Listing
June 2021

Uniaxial 3D Measurement with Auto-Synchronous Phase-Shifting and Defocusing Based on a Tilted Grating.

Sensors (Basel) 2021 May 27;21(11). Epub 2021 May 27.

Department of Opto-Electronic, Sichuan University, Chengdu 610065, China.

Conventional uniaxial techniques generally require shifting objects or projection grating with the assistance of a high-precision mechanical moving component. To overcome this limitation, we propose a novel uniaxial 3-D shape measurement system with auto-synchronous phase-shifting and defocusing by using a tilted and fixed projection grating. The tilted focused image plane (FIP), which is reflected by a mirror at about 90 degrees, could be shifted across the measured surface by slightly rotating the mirror within a small angle range. This procedure will simultaneously introduce the change in defocusing and phase-shifting of the fringe. The modulation curve of each point can be deciphered by Fourier fringe analysis after a sequence of fringe intensities is acquired. Since both the measured object and projection grating are fixed, the proposed method could make the measurement system more compact and flexible. Both computer simulation and experiments are carried out to demonstrate the validity of this proposed system.
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http://dx.doi.org/10.3390/s21113730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198073PMC
May 2021

A Novel Portable Gamma Radiation Sensor Based on a Monolithic Lutetium-Yttrium Oxyorthosilicate Ring.

Sensors (Basel) 2021 May 12;21(10). Epub 2021 May 12.

Shenzhen Bay Laboratory, The Institute of Biomedical Engineering, Shenzhen 518132, China.

Portable radiation detectors are widely used in environmental radiation detection and medical imaging due to their portability feature, high detection efficiency, and large field of view. Lutetium-yttrium oxyorthosilicate (LYSO) is a widely used scintillator in gamma radiation detection. However, the structure and the arrangement of scintillators limit the sensitivity and detection accuracy of these radiation detectors. In this study, a novel portable sensor based on a monolithic LYSO ring was developed for the detection of environmental radiation through simulation, followed by construction and assessments. Monte Carlo simulations were utilized to prove the detection of gamma rays at 511 keV by the developed sensor. The simulations data, including energy resolutions, decoding errors, and sensitivity, showed good potential for the detection of gamma rays by the as-obtained sensor. The experimental results using the VA method revealed decoding errors in the energy window width of 50 keV less than 2°. The average error was estimated at 0.67°, a sufficient value for the detection of gamma radiation. In sum, the proposed radiation sensor appears promising for the construction of high-performance radiation detectors and systems.
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http://dx.doi.org/10.3390/s21103376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150370PMC
May 2021

Carbon Nanomaterials for Enhancing the Thermal, Physical and Rheological Properties of Asphalt Binders.

Materials (Basel) 2021 May 16;14(10). Epub 2021 May 16.

State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China.

Effective thermal conduction modification in asphalt binders is beneficial to reducing pavement surface temperature and relieving the urban heat island (UHI) effect in the utilization of solar harvesting and snow melting pavements. This study investigated the performance of two nanometer-sized modifiers, graphene (Gr) and carbon nanotubes (CNTs), on enhancing the thermal, physical and rheological properties of asphalt binders. Measurements depending on a transient plant source method proved that both Gr and CNTs linearly increased the thermal conductivity and thermal diffusivity of asphalt binders, and while 5% Gr by volume of matrix asphalt contributed to 300% increments, 5% CNTs increased the two parameters of asphalt binders by nearly 72% at 20 °C. Meanwhile, a series of empirical and rheological properties experiments were conducted. The results demonstrated the temperature susceptibility reduction and high-temperature properties promotion of asphalt binders by adding Gr or CNTs. The variation trends in the anti-cracking properties of asphalt binders modified by Gr and CNTs with the modifier content differed at low temperatures, which may be due to the unique nature of Gr. In conclusion, Gr, whose optimal content is 3% by volume of matrix asphalt, provides superior application potential for solar harvesting and snow melting pavements in comparison to CNTs due to its comprehensive contributions to thermal properties, construction feasibility, high-temperature performance and low-temperature performance of asphalt binders.
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http://dx.doi.org/10.3390/ma14102585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156440PMC
May 2021

The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma.

Cancer Cell Int 2021 May 31;21(1):286. Epub 2021 May 31.

Hepato-Biliary-Pancreatic Surgery Division, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Nanchang, 330006, China.

Background: The HSP70 family of heat shock protein plays a critical role in protein synthesis and transport to maintain protein homeostasis. Several studies have indicated that HSP70s are related to the development and occurrence of various cancers.

Methods: The relationship between the overall survival rate of hepatocellular carcinoma patients and the expression of 14 HSP70s from multiple databases, such as TCGA, ONCOMINE, cBioPortal was investigated. Western Blot and PCR were used to evaluate HSPA4 and HSPA14 expressions in various HCC cells to identify suitable cell lines for further experiments .Wound-healing assays, Transwell assays and EdU assays were used to verify the effects of HSPA4 and HSPA14 on the function of hepatocellular carcinoma cells, and statistical analysis was performed.

Results: Hepatocellular carcinoma tissues significantly expressed the 14 HSP70s compared to the normal samples. Besides, the high HSPA1A, HSPA1B, HSPA4, HSPA5, HSPA8, HSPA13, and HSPA14 expressions were inversely associated with the overall survival rate of patients, tumor grade, and cancer stage. A PPI regulatory network was constructed using the 14 HSP70s proteins with HSPA5 and HSPA8 at the network center. Univariate and multivariate analyses showed that HSPA4 and HSPA14 could be independent risk factors for the prognosis of hepatocellular carcinoma patients. Cell experiments have also confirmed that reducing HSPA4 and HSPA14 expressions can inhibit the invasion, metastasis, and proliferation of hepatocellular carcinoma cells.

Conclusions: Therefore, the HSP70s significantly influence the occurrence and development of hepatocellular carcinoma. For instance, HSPA4 and HSPA14 can be novel therapeutic targets and prognostic biomarkers for hepatocellular carcinoma.
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http://dx.doi.org/10.1186/s12935-021-01987-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165812PMC
May 2021

Evaluation of Long-term Outcomes and Toxicity after Stereotactic Phosphorus-32 Based Intracavitary Brachytherapy in Patients with Cystic Craniopharyngioma.

Int J Radiat Oncol Biol Phys 2021 May 28. Epub 2021 May 28.

Geisinger Health Care, Department of Radiation Oncology, Danville, Pennsylvania, USA; Division of Neurosurgery, McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada. Electronic address:

Introduction: Phosphorus-32-based interstitial brachytherapy has an established role as a minimally invasive treatment modality for patients with cystic craniopharyngioma. However, reporting on long-term outcomes with toxicity profiles for large cohorts is lacking in the literature. The purpose of this study is therefore to evaluate the long-term visual, endocrine and neurocognitive function in what is the largest patient series having received this treatment to date.

Methods: Ninety patients with cystic craniopharyngiomas were retrospectively evaluated after having been treated with stereotactic intracavitary brachytherapy between 1998 and 2010. Colloidal activity of injected radioisotope phosphorus-32 was based on an even distribution within the tumor. After treatment, patients were followed-up for a minimum of five years and over a mean of 121 (60-192) months to assess radiographic and clinical response.

Results: The 90 patients included in our study cohort underwent a total of 108 stereotactic surgical procedures for 129 craniopharyngioma-related cysts. Sixty-five (72.2%) of included tumors were associated with a single cyst, 15 (16.7%) with 2 cysts, and 10 (11.1%) tumors had developed septations with 3-4 cysts. Stereotactic cyst puncture and content aspiration was used to drain a mean cyst fluid volume of 21.4 (1.0-55.0) ml. Each cyst was then instilled for interstitial brachytherapy with colloidal P-32 solution. Based on radiographic follow-up assessment, 56 cysts (43.4%) showed resolution and/or non-recurrence which was classified as complete response to treatment, 47 cysts (36.4%) showed partial response, whereas 5 cysts (3.9%) displayed a stable appearance. Treatment resulted in immediate and clinically significant vision improvement in 54 of 63 (86%) symptomatic patients and this improvement was maintained. Progression-free survival at 5 and 10 years was 95.5% and 84.4%, respectively.

Conclusion: P-32-based interstitial brachytherapy can play an effective role in managing patients with cystic craniopharyngiomas. It can be considered a valid alternative to surgery in select patients with a favorable toxicity profile and long-term clinical outcomes.
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http://dx.doi.org/10.1016/j.ijrobp.2021.05.123DOI Listing
May 2021

EnMCB: an R/bioconductor package for predicting disease progression based on methylation correlated blocks using ensemble models.

Authors:
Xin Yu De-Xin Kong

Bioinformatics 2021 May 29. Epub 2021 May 29.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.

Motivation: Based on the concept that adjacent CpG sites in the same DNA strand may be modified by a methyltransferase or demethylase together, current study found that the combination of multiple CpGs into a single block may improve cancer diagnosis. However, there is no R package available for building models based on methylation correlated blocks.

Results: Here, we present a package named stacked ensemble of machine learning models for methylation correlated blocks (EnMCB) to build signatures based on DNA methylation correlated blocks for survival prediction. The Cox regression, support vector regression, mboost and elastic-net model were combined in the ensemble model. Methylation profiles from Cancer Genome Atlas were used as real datasets. The package automatically partitions the genome into blocks of tightly co-methylated CpG sites, termed methylation correlated blocks. After partitioning and modeling, the diagnostic capacities for predicting patients' survival are given.

Availability: EnMCB is freely available for download at GitHub (https://github.com/whirlsyu/EnMCB/) and Bioconductor (http://bioconductor.org/packages/release/bioc/html/EnMCB.html).

Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://dx.doi.org/10.1093/bioinformatics/btab415DOI Listing
May 2021

TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways.

Curr Med Sci 2021 May 28. Epub 2021 May 28.

Department of Ophthalmology, Jiangxi Provincial Children's Hospital, Nanchang, 330006, China.

The exact mechanism by which knockout of Toll-like receptor 4 (TLR4) attenuates the liver injury remains unclear. The present study aimed to examine the role of TLR4 in the pathogenesis of bile duct ligation (BDL)-induced liver cholestatic injury and the underlying mechanism. Wild type (WT) mice and TLR4 knockout (TLR4-KO) mice were used for the establishment of the BDL model. Metabolomics were applied to analyze the changes of small molecular metabolites in the serum and liver of the two groups. The serum biochemical indexes and the HE staining results of liver tissue showed that liver damage was significantly reduced in TLR4-KO mice after BDL when compared with that in WT mice. The metabolite analysis results showed that TLR4 KO could maintain the metabolisms of amino acids- and choline-related metabolites. After BDL, the amino acids- and choline-related metabolites, especially choline and 3-hydroxybutyrate, were significantly increased in WT mice (both in serum and liver), but these metabolites in the liver of TLR4-KO mice after BLD were not significant different from those before BLD. In conclusion, TLR4 KO could attenuate BDL-induced liver cholestatic injury through regulating amino acid and choline metabolic pathways.
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http://dx.doi.org/10.1007/s11596-021-2364-8DOI Listing
May 2021

Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia.

Schizophr Res 2021 May 24;232:77-84. Epub 2021 May 24.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China; Sino-Danish Center for Education and Research, Beijing, China. Electronic address:

Social behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting-state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders.
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http://dx.doi.org/10.1016/j.schres.2021.05.016DOI Listing
May 2021

Investigation of the evolution and control of fractures in surrounding rock under different pressure relief and support measures in mine roadways prone to rockburst events.

R Soc Open Sci 2021 Mar 31;8(3):202044. Epub 2021 Mar 31.

School of Mines, China University of Mining and Technology, Xuzhou, Jiangsu 221116, People's Republic of China.

This paper studies the evolution and control of surrounding rock under different pressure relief support conditions in mine roadways in which rockburst events have occurred. The evolution of fractures in the surrounding rock was determined from borehole images obtained with a digital panoramic borehole camera, and the surface displacement due to the rockburst events in the mine roadway was measured. According to the existing problems of the original support system of the roadway, a new coupled support system to prevent rockburst events in mine roadways was proposed, resolving both the pressure relief and support of the roadway. Field measurements indicate that the effect on the roadway under the coupled method of pressure relief and support was more satisfactory than that under the original support system. With the coupled support method, the surface displacement of the roadway was approximately 0.6 m, fractures were distributed only in the soft structures and bolt anchorage areas, and the maximum depth of the fractures was 2.95 m. By contrast, under the original support system, fractures were distributed throughout the roadway surrounding rock, and the maximum depth of fractures was 6.75 m. This coupled roadway support technology of pressure relief and support effectively maintains the stability of the rock surrounding the roadway and ensures the safety of the working face. The research results can provide a reference for damage prevention and support of mine roadways prone to rockburst events.
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http://dx.doi.org/10.1098/rsos.202044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101539PMC
March 2021

In Situ Surface Fluorination of TiO Nanocrystals Reinforces Interface Binding of Perovskite Layer for Highly Efficient Solar Cells with Dramatically Enhanced Ultraviolet-Light Stability.

Adv Sci (Weinh) 2021 May 13;8(10):2004662. Epub 2021 Mar 13.

Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Materials for Energy Conversion Anhui Laboratory of Advanced Photon Science and Technology Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China.

Low-temperature solution-processed TiO nanocrystals (LT-TiO) have been extensively applied as electron transport layer (ETL) of perovskite solar cells (PSCs). However, the low electron mobility, high density of electronic trap states, and considerable photocatalytic activity of TiO result in undesirable charge recombination at the ETL/perovskite interface and notorious instability of PSCs under ultraviolet (UV) light. Herein, LT-TiO nanocrystals are in situ fluorinated via a simple nonhydrolytic method, affording formation of Ti─F bonds, and consequently increase electron mobility, decrease density of electronic trap states, and inhibit photocatalytic activity. Upon applying fluorinated TiO nanocrystals (F-TiO) as ETL, regular-structure planar heterojunction PSC (PHJ-PSC) achieves a champion power conversion efficiency (PCE) of 22.68%, which is among the highest PCEs for PHJ-PSCs based on LT-TiO ETLs. Flexible PHJ-PSC devices based on F-TiO ETL exhibit the best PCE of 18.26%, which is the highest value for TiO-based flexible devices. The bonded F atoms on the surface of TiO promote the formation of Pb─F bonds and hydrogen bonds between F and FA/MA organic cations, reinforcing interface binding of perovskite layer with TiO ETL. This contributes to effective passivation of the surface trap states of perovskite film, resulting in enhancements of device efficiency and stability especially under UV light.
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http://dx.doi.org/10.1002/advs.202004662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132056PMC
May 2021

Persistent Labial Minora Fusion in Reproductive Age Women: A Retrospective Case Series of Nine Patients and Review of Literature.

Organogenesis 2021 Apr 20;17(1-2):20-25. Epub 2021 May 20.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.

Labial minora fusion persisting to the reproductive age is a rare type of labial fusion. Only 17 sporadic case-reports have been published to describe this disease. We report a retrospective cohort study of nine patients undergone surgical dissections in our hospital with labial minora fusion of reproductive age. General information, a medical history, gynecological examinations, preoperative ultrasonography and observations during surgery were reviewed. Four patients found vulva deformity at age 1.25 ± 1.09 years, and the remaining 5 patients discovered the disease when they reached child-bearing age (25.20 ± 4.31). The average age of operation was 22.89 ± 6.21 years. The characteristic symptoms of the disease were menstrual blood and urine excretion from the urethral orifice. No endometriosis was detected in all 9 patients. One patient was found to have congenital defects, with a double cervical and complete uterine septum. All patients recovered well without re-adhesion. Seven patients (7/9, 77.80%) were interviewed by telephone. Three patients had normal sexual life and all patients were able to control urination normally. This labial fusion was found in 44.44% patients shortly after birth and might combined with other defects, suggesting a congenital nature of the disease, and further indicates the developmental feature of the vulva.
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http://dx.doi.org/10.1080/15476278.2021.1905477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162252PMC
April 2021

Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs.

Nat Commun 2021 05 18;12(1):2928. Epub 2021 May 18.

Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.

Small interfering RNA (siRNA) is an effective therapeutic to regulate the expression of target genes in vitro and in vivo. Constructing a siRNA delivery system with high serum stability, especially responsive to endogenous stimuli, remains technically challenging. Herein we develop anti-degradation Y-shaped backbone-rigidified triangular DNA bricks with sticky ends (sticky-YTDBs) and tile them onto a siRNA-packaged gold nanoparticle in a programmed fashion, forming a multi-functional three-dimensional (3D) DNA shell. After aptamers are arranged on the exterior surface, a biocompatible siRNA-encapsulated core/shell nanoparticle, siRNA/Ap-CS, is achieved. SiRNAs are internally encapsulated in a 3D DNA shell and are thus protected from enzymatic degradation by the outermost layer of YTDB. The siRNAs can be released by endogenous miRNA and execute gene silencing within tumor cells, causing cell apoptosis higher than Lipo3000/siRNA formulation. In vivo treatment shows that tumor growth is completely (100%) inhibited, demonstrating unique opportunities for next-generation anticancer-drug carriers for targeted cancer therapies.
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http://dx.doi.org/10.1038/s41467-021-23250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131747PMC
May 2021

Posttraumatic stress disorder and professional burnout among local government staff seven years after the Wenchuan earthquake in China: A longitudinal study.

Asian J Psychiatr 2021 Jul 10;61:102689. Epub 2021 May 10.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.

Although local government staff are crucial in post-quake reconstruction, their long-term psychological and professional consequences remain unclear. This longitudinal study investigated changes of posttraumatic stress disorder (PTSD) and professional burnout over seven years, and their underlying relationship. The study assessed 250 staff at one year (T) after the earthquake, and 162 (64.8 %) were followed up at seven years (T). PTSD and professional burnout were assessed with the Short Screening Scale for DSM-IV PTSD and the burnout subscale of Professional Quality of Life Scale (ProQOL), respectively, at both time points. Longitudinal changes in PTSD and burnout were examined and cross-lagged panel analyses were conducted to test the relationship between PTSD and burnout. The rates of positive cases of PTSD screening were 23.2 % at T and 11.1 % at T. The percentages of moderate burnout were 61.7 % at T and 23.5 % at T. Scores of PTSD (z = -5.70, p < 0.001) and burnout (t = 10.07, p < 0.001) from T to T decreased. The cross-lagged analysis indicated that burnout at T predicted PTSD at T (β = 0.19, p = 0.025). In conclusion, the Wenchuan earthquake has long-lasting negative effects on local government staff, although they can recover over time. Interventions to reduce professional burnout after disaster may does be beneficial to decrease the risk of PTSD in the long run.
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http://dx.doi.org/10.1016/j.ajp.2021.102689DOI Listing
July 2021

Mechanistic insight of simultaneous removal of tetracycline and its related antibiotic resistance bacteria and genes by ferrate(VI).

Sci Total Environ 2021 Sep 3;786:147492. Epub 2021 May 3.

College of the Environment and Ecology, Xiamen University, Xiamen 361102, China. Electronic address:

The emergence of antibiotics and their corresponding antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have posed great challenges to the public health. The paper demonstrates the removal of co-existing tetracycline (TC), its resistant Escherichia coli (E. coli), and ARGs (tetA and tetR) in a mixed system by applying ferrate(VI) (FeO, Fe(VI)) at pH 7.0. TC was efficiently degraded by Fe(VI), and the rapid inactivation of the resistant E. coli was found with the complete loss of culturability. The results of flow cytometry suggested that the damage of membrane integrity and respiratory activity were highly correlated with the Fe(VI) dosages. Moreover, high-dose Fe(VI) eliminates 6 log viable but non-culturable (VBNC) cells and even breaks the cells into fragments. ARGs in extracellular form (e-ARGs) exhibited a high sensitivity of 4.44 log removal to Fe(VI). Comparatively, no removal of intracellular ARGs (i-ARGs) was observed due to the multi-protection of cellular structure and rapid decay of Fe(VI). The oxidized products of TC were assessed to be less toxic than the parent compound. Overall, this study demonstrated the superior efficiency and great promise of Fe(VI) on simultaneous removal of antibiotics and their related ARB and ARGs in water.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147492DOI Listing
September 2021

Ventilation improvement after pneumonia treatment evaluated with electrical impedance tomography: an observational study.

Physiol Meas 2021 May 10. Epub 2021 May 10.

Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, 710032, CHINA.

Objective: Due to radiation exposures, not all patients with pneumonia would receive chest x-ray or CT measurements to confirm treatment effectiveness. The aim of the study was to examine the ability of using electrical impedance tomography (EIT) to evaluate the treatment effectiveness in such patient group.

Methods: A total of 35 consecutive patients with non-severe pneumonia was included in this prospective study. The patients received standard treatment according to our internal protocol. EIT measurements were performed in supine position before the treatment start and on day 6 of the treatment period. EIT-based global inhomogeneity (GI) index and center of ventilation index (CoV) were calculated. Clinical pulmonary infection score (CPIS) was obtained at both time points.

Results: Clinically significant improvements in GI and CoV were found in patient group (ΔGI: -34%±17% and ΔCoV: -10%±11%; p<0.001). Although CPIS was also significantly improved (ΔCPIS -0.70±0.17, p<0.001), no correlations were demonstrated when it compared to ΔGI or ΔCoV.

Conclusion: EIT demonstrated individual improvement of ventilation heterogeneity after standard treatment in non-severe pneumonia, which provided different information compared to CPIS. EIT has the potential to become a routine non-invasive, non-radiative tool to assess pneumonia treatment effectiveness.
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http://dx.doi.org/10.1088/1361-6579/abffbfDOI Listing
May 2021

Learning With Noisy Labels via Self-Reweighting From Class Centroids.

IEEE Trans Neural Netw Learn Syst 2021 May 7;PP. Epub 2021 May 7.

Although deep neural networks have been proved effective in many applications, they are data hungry, and training deep models often requires laboriously labeled data. However, when labeled data contain erroneous labels, they often lead to model performance degradation. A common solution is to assign each sample with a dynamic weight during optimization, and the weight is adjusted in accordance with the loss. However, those weights are usually unreliable since they are measured by the losses of corrupted labels. Thus, this scheme might impede the discriminative ability of neural networks trained on noisy data. To address this issue, we propose a novel reweighting method, dubbed self-reweighting from class centroids (SRCC), by assigning sample weights based on the similarities between the samples and our online learned class centroids. Since we exploit statistical class centers in the image feature space to reweight data samples in learning, our method is robust to noise caused by corrupted labels. In addition, even after reweighting the noisy data, the decision boundaries might still suffer distortions. Thus, we leverage mixed inputs that are generated by linearly interpolating two random images and their labels to further regularize the boundaries. We employ the learned class centroids to evaluate the confidence of our generated mixed data via measuring feature similarities. During the network optimization, the class centroids are updated as more discriminative feature representations of original images are learned. In doing so, SRCC will generate more robust weighting coefficients for noisy and mixed data and facilitates our feature representation learning in return. Extensive experiments on both the synthetic and real image recognition tasks demonstrate that our method SRCC outperforms the state of the art on learning with noisy data.
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http://dx.doi.org/10.1109/TNNLS.2021.3073248DOI Listing
May 2021

A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI.

Curr Opin Biomed Eng 2021 Jun 12;18. Epub 2021 Feb 12.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Recent developments in optical microscopy, applicable for large-scale and longitudinal imaging of cortical activity in behaving animals, open unprecedented opportunities to gain a deeper understanding of neurovascular and neurometabolic coupling during different brain states. Future studies will leverage these tools to deliver foundational knowledge about brain state-dependent regulation of cerebral blood flow and metabolism as well as regulation as a function of brain maturation and aging. This knowledge is of critical importance to interpret hemodynamic signals observed with functional magnetic resonance imaging (fMRI).
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http://dx.doi.org/10.1016/j.cobme.2021.100273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095678PMC
June 2021

Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1.

World J Gastroenterol 2021 Apr;27(15):1595-1615

Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, China.

Background: Expression of the full-length isoform of Abelson interactor 1 (ABI1), ABI1-p65, is increased in colorectal carcinoma (CRC) and is thought to be involved in one or more steps leading to tumor progression or metastasis. The ABI1 splice isoform-L (ABI1-SiL) has conserved WAVE2-binding and SH3 domains, lacks the homeo-domain homologous region, and is missing the majority of PxxP- and Pro-rich domains found in full-length ABI1-p65. Thus, ABI1-SiL domain structure suggests that the protein may regulate CRC cell morphology, adhesion, migration, and metastasis interactions with the WAVE2 complex pathway.

Aim: To investigate the potential role and underlying mechanisms associated with ABI1-SiL-mediated regulation of CRC.

Methods: ABI1-SiL mRNA expression in CC tissue and cell lines was measured using both qualitative reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time quantitative RT-PCR. A stably ABI1-SiL overexpressing SW480 cell model was constructed using Lipofectamine 2000, and cells selected with G418. Image J software, CCK8, and transwell assays were used to investigate SW480 cell surface area, proliferation, migration, and invasion. Immunoprecipitation, Western blot, and co-localization assays were performed to explore intermolecular interactions between ABI1-SiL, WAVE2, and ABI1-p65 proteins.

Results: ABI1-SiL was expressed in normal colon tissue and was significantly decreased in CRC cell lines and tissues. Overexpression of ABI1-SiL in SW480 cells significantly increased the cell surface area and inhibited the adhesive and migration properties of the cells, but did not alter their invasive capacity. Similar to ABI1-p65, ABI1-SiL still binds WAVE2, and the ABI1-p65 isoform in SW480 cells. Furthermore, co-localization assays confirmed these intermolecular interactions.

Conclusion: These results support a model in which ABI1-SiL plays an anti-oncogenic role by competitively binding to WAVE2 and directly interacting with phosphorylated and non-phosphorylated ABI1-p65, functioning as a dominant-negative form of ABI1-p65.
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http://dx.doi.org/10.3748/wjg.v27.i15.1595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058658PMC
April 2021

A cortical circuit mechanism for structural knowledge-based flexible sensorimotor decision-making.

Neuron 2021 Jun 5;109(12):2009-2024.e6. Epub 2021 May 5.

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of the Chinese Academy of Sciences, Beijing 100049, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China. Electronic address:

Making flexible decisions based on prior knowledge about causal environmental structures is a hallmark of goal-directed cognition in mammalian brains. Although several association brain regions, including the orbitofrontal cortex (OFC), have been implicated, the precise neuronal circuit mechanisms underlying knowledge-based decision-making remain elusive. Here, we established an inference-based auditory categorization task where mice performed within-session flexible stimulus re-categorization by inferring the changing task rules. We constructed a reinforcement learning model to recapitulate the inference-based flexible behavior and quantify the hidden variables associated with task structural knowledge. Combining two-photon population imaging and projection-specific optogenetics, we found that auditory cortex (ACx) neurons encoded the hidden task rule variable, which requires feedback input from the OFC. Silencing OFC-ACx input specifically disrupted re-categorization behavior. Direct imaging from OFC axons in the ACx revealed task state-related feedback signals, supporting the knowledge-based updating mechanism. Our data reveal a cortical circuit mechanism underlying structural knowledge-based flexible decision-making.
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http://dx.doi.org/10.1016/j.neuron.2021.04.014DOI Listing
June 2021

Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis.

Life Sci 2021 Aug 1;278:119551. Epub 2021 May 1.

School of Medicine and State Key Laboratory of Medicinal Chemical Biology, Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address:

Studies reported that sodium hydrosulfide (NaHS) can remit the depressive-like and anxiety-like behaviors induced by type 1 diabetes mellitus (T1DM). However, the mechanism is still unclear. In this study, we aimed to investigate the mechanism of NaHS on T1DM. Mice were randomly divided into four groups, including the control group (CON group), DM group, DM + 5.6 mg/kg NaHS group, and CON + 5.6 mg/kg NaHS group. Data showed that NaHS did attenuate the depressive-like and anxiety-like behaviors by OFT, EPM test, FST, and TST. Results suggest that NaHS markedly alleviated the ferroptosis in the prefrontal cortex (PFC) of diabetic mice by reducing iron deposition and oxidative stress, increasing the expression of GPX4 and SLC7A11. Moreover, NaHS could dampen the activation of microglias and the release of pro-inflammatory cytokines, enhance the protein expression of sirtuin 6 (Sirt6) and the interaction between Sirt6 and the acetylation of histoneH3 lysine9 (H3K9ac), and decrease the protein expressions of the Notch1 receptor and H3K9ac. In vitro experiment, NaHS ameliorated the ferroptosis via increasing the protein expressions of SLC7A11, glutathione peroxidase 4 (GPX4), and cystathionine β-synthase (CBS), reducing the pro-inflammatory cytokines, decreasing the levels of Fe, MDA, ROS, and lipid ROS. In conclusion, our results suggested that NaHS did alleviate anxiety-like and depressive-like behaviors. It can inhibit inflammation via modulating Sirt6 and was able to decrease the ferroptosis in the PFC of type 1 diabetic mice and the BV2 cells.
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http://dx.doi.org/10.1016/j.lfs.2021.119551DOI Listing
August 2021

Reliability and Validity of the Chinese Version of Mild Behavioral Impairment Checklist in Mild Cognitive Impairment and Mild Alzheimer's Disease.

J Alzheimers Dis 2021 ;81(3):1141-1149

Dementia Care & Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.

Background: Mild behavioral impairment (MBI) has been proposed as an early manifestation of dementia. The Mild Behavioral Impairment Checklist (MBI-C) may help identify MBI in prodromal and preclinical dementia.

Objective: The study aimed to evaluate the reliability and validity of the Chinese version of MBI-C in mild cognitive impairment (MCI) and mild Alzheimer's disease (AD), and to explore the structure of the five factors of the MBI-C in Chinese culture.

Methods: Sixty dyads of MCI and mild AD (MCI, n = 33; mild AD, n = 35) were recruited. The informants completed the MBI-C and Neuropsychiatric Inventory Questionnaire (NPI-Q) and were interviewed for clinician rating of the NPI. The Cronbach's coefficient was used to measure the structural reliability of the MBI-C. The criterion-validity was evaluated with the correlation coefficient between the MBI-C and the total scores of NPI-Q and NPI. Exploratory factor analysis was conducted to investigate the structure of the MBI-C.

Results: The Cronbach's α coefficient was 0.895. The MBI-C total score was positively correlated with all five domains (r = 0.577∼0.840). The total score of MBI-C was significantly correlated with the total scores of NPI-Q (r = 0.714) and NPI (r = 0.749). Similarly, the five domain scores of MBI-C were significantly correlated with the factor and total scores of NPI-Q (r = 0.312∼0.673) and NPI (r = 0.389∼0.673). The components of each factor in Chinese version of MBI-C were slightly different from those of the a priori defined domains (χ2 = 1818.202, df = 496, p < 0.001).

Conclusion: The Chinese version of MBI-C has good reliability and validity, and can be used to evaluate the psychological and behavioral changes in MCI and mild AD.
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http://dx.doi.org/10.3233/JAD-210098DOI Listing
January 2021

An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth.

Transl Oncol 2021 Jul 28;14(7):101103. Epub 2021 Apr 28.

CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China; Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, Anhui 230026, China; Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China; International Magnetobiology Frontier Research Center (iMFRC), Science Island, 230031, China. Electronic address:

Studies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages in improving image resolution and capacity, but their safety issues need to be further validated before their clinical approval. Meanwhile, emerging experimental evidences show that moderate to high intensity Static Magnetic Fields (SMFs) have some anti-cancer effects. We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lung cancer cell-bearing mice were treated with 9.4 T SMFs for 88 h in total, the upward 9.4 T SMF significantly inhibited A549 tumor growth (tumor growth inhibition=41%), but not the downward 9.4 T SMF. In vitro cellular analysis shows that 9.4 T upward SMF treatment for 24 h not only inhibited A549 DNA synthesis, but also significantly increased ROS and P53 levels, and arrested G2 cell cycle. Moreover, the 9.4 T SMF-treatments for 88 h had no severe impairment to the key organs or blood cell count of the mice. Our findings demonstrated the safety of 9.4 T SMF long-term exposure for their future applications in MRI, and revealed the anti-cancer potential of the upward direction 9.4 T SMF.
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http://dx.doi.org/10.1016/j.tranon.2021.101103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102172PMC
July 2021

Synthesis of a Stable Benzoxazole Gel from an Imine Gel for Adsorption and Catalysis.

Langmuir 2021 May 29;37(18):5531-5539. Epub 2021 Apr 29.

MOE Laboratory of Polymeric Composite and Functional Materials, School of Materials Science and Engineering, School of Chemical Engineering and Technology, Sun Yat-Sen University, Guangzhou 510275, China.

Developing stable gel materials for adsorption and catalysis is one of the major themes of gel materials. However, it has been proven to be challenging to achieve them from small molecules. Herein, an imine gel is developed from tetra-aldehyde 4-{2,2-bis[(4-formylphenoxy)methyl]-3-(4-formylphenoxy)propoxy}benzaldehyde (A4) and 3,3'-dihydroxybenzidine (B2) based on dynamic covalent chemistry. The unstable A4B2-imine gel is further converted into a stable aromatic benzoxazole-linked A4B2-benzoxazole gel via oxidative cyclization, which has significantly improved chemical stability under acidic and basic conditions. Benefiting from the stability under acidic conditions, the A4B2-benzoxazole gel is used for Pd(II) adsorption and the adsorption capacity is 250 mg g. After PdCl immersion and reduction, palladium nanoparticles with a size distribution of 1.3-14.7 nm are encapsulated by the network structure of the stable porous benzoxazole gel matrix. The [email protected] gel exhibits high catalytic activity toward the reduction of toxic hexavalent chromium Cr(VI) (reaction rate constant = 0.0377 min), while there is no significant decrease in the catalytic efficiency after five cycles.
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http://dx.doi.org/10.1021/acs.langmuir.1c00272DOI Listing
May 2021

IL-37 Was Involved in Progress of Acute Myeloid Leukemia Through Regulating IL-6 Expression.

Cancer Manag Res 2021 19;13:3393-3402. Epub 2021 Apr 19.

Center for Laboratory Diagnosis, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai Shandong, 264000, People's Republic of China.

Background: Interleukin-37, which was discovered in 2000, is a natural suppressor of immune and inflammatory responses. Recent studies reported that IL-37 was abnormally expressed in several tumor patients, including those with hepatocellular carcinoma, gastric cancer, lung cancer, colon cancer, epithelial ovarian cancer, and multiple myeloma. However, the expression and potential function of IL-37 in leukemia remain unknown.

Objective: The aim of this study was to evaluate IL-37 as a prognostic factor and its possible mechanism of action.

Methods: Polymerase chain reaction products were analyzed by agarose gel electrophoresis and were purified and subsequently sequenced by a genetic testing laboratory. Human PBMC was purified from whole blood samples by using Ficoll-Paque PLUS. The concentrations of human IL-37 and human IL-6 were measured using enzyme-linked immunosorbent assay (ELISA) kits.

Results: IL-37, especially isoform b and d, was expressed in the bone marrow of AML, CML, ALL, and CLL. Importantly, IL-37 expression was downregulated in newly diagnosed AML patients and restored in patients in complete remission. Moreover, a significant association was found between IL-37 expression and NPM1 mutation or possible prognosis evaluated by karyotype and gene mutation. Further analysis revealed that IL-37 expression was negatively correlated with IL-6 expression. With regard to the mechanism, recombinant human IL-37 could suppress IL-6 expression stimulated by LPS in PBMC of AML patients.

Conclusion: Our study suggested that IL-37 may be an important prognostic factor in AML and is involved in AML via the IL-6 signaling pathway, indicating that IL-37 is an innovative research strategy for AML pathogenesis and therapy.
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http://dx.doi.org/10.2147/CMAR.S303017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064683PMC
April 2021

Transthyretin affects the proliferation and migration of human retinal microvascular endothelial cells in hyperglycemia via hnRNPA2B1.

Biochem Biophys Res Commun 2021 Jun 21;557:280-287. Epub 2021 Apr 21.

Department of Ophthalmology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, Jiangsu, China. Electronic address:

Transthyretin (TTR) has been proved to repress neovascularization in diabetic retinopathy environment by regulating the molecules in and downstream of the STAT-4/miR-223-3p/FBXW7 signal pathway; however, the details of its direct targets are still not well understood. The interaction between TTR and a target in nucleus of human retinal microvascular endothelial cells (hRECs), heterogeneous nuclear ribonucleoprotein (hnRNP) A2B1, was screened by immunoprecipitation (IP) and mass spectrum (MS), and it was further confirmed by co-immunoprecipitation (co-IP). Regarding ZDOCK analysis using Discovery Studio, the interface and potential binding sites between TTR and hnRNPA2B1 were simulated; mutants were designed in these regions and five soluble ones were recombinantly expressed and prepared; the interaction between TTR and hnRNPA2B1 were disrupted by several mutated residues. In addition, for several mutated TTRs, the inhibition activities against the proliferation, migration and tube formation of hRECs were absent in vitro. Following the disruption of TTR-hnRNPA2B1, the molecules in and downstream of STAT-4/miR-223-3p/FBXW7 signal pathway, including STAT-4, miR-223-3p, FBXW7 p-Akt and Notch1 could not be regulated by TTR mutants; therefore, a TTR-hnRNPA2B1/STAT-4/miR-223-3p/FBXW7 was proposed. In conclusion, this work suggested that TTR should play a physiological role in diabetic environment by the direct binding with hnRNPA2B1, and it provided a theoretical basis for clinical diagnosis, therapy and further application.
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http://dx.doi.org/10.1016/j.bbrc.2021.04.035DOI Listing
June 2021

Safety survey by clinical pharmacists on COVID-19 vaccination from a single center in China.

Hum Vaccin Immunother 2021 Apr 22:1-5. Epub 2021 Apr 22.

Department of Clinical Pharmacy, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

This study explored the safety of COVID-19 vaccine (Aikewei) and the role of clinical pharmacists in the implementation of COVID-19 vaccination. A total of 2305 hospital employees in Children's Hospital of Fudan University in Shanghai, China received the COVID-19 vaccine. The whole process of vaccination was monitored by clinical pharmacists, and the occurrence, types, severity of adverse reactions were recorded in detail. Through the investigation and analysis on the safety of COVID-19 vaccination of the 2305 people, the important role and value of clinical pharmacists in the vaccination process was elaborated. Common adverse reactions included local pain, dizziness and fatigue, with the incidence rates of 2.09%, 0.67% and 0.49%, respectively. Others such as headache, nausea, skin itching, cough, palpitation, dry mouth, hand anesthesia, local induration, muscle soreness, local rash, and chill had incidence rates of less than 0.30%. Three cases of serious adverse events that occurred in this vaccination returned to normal after treatment, with no subsequent discomfort. Clinical pharmacists played an important role in the safety monitoring of COVID-19 vaccination. The safety of the inactivated COVID-19 vaccine is good. Most of the common adverse reactions were mild and tolerable, with generally low incidence. The work of clinical pharmacists is important and can be expanded in the future to ensure the safety of vaccination and to provide better health care service.
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http://dx.doi.org/10.1080/21645515.2021.1913964DOI Listing
April 2021