Xin Xiao Zheng

Xin Xiao Zheng

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Xin Xiao Zheng

Xin Xiao Zheng

Publications by authors named "Xin Xiao Zheng"

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A Critical Role for TGF-β/Fc and Nonlytic IL-2/Fc Fusion Proteins in Promoting Chimerism and Donor-Specific Tolerance.

Transplantation 2017 02;101(2):294-301

1 Institute for Cellular Therapeutics, University of Louisville, Louisville, KY. 2 Thomas Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1097/TP.0000000000001283DOI Listing
February 2017

Site-specific immunosuppression in vascularized composite allotransplantation: prospects and potential.

Clin Dev Immunol 2013 13;2013:495212. Epub 2013 Feb 13.

Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1155/2013/495212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586464PMC
July 2013

Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats.

Clin Dev Immunol 2013 12;2013:483856. Epub 2013 Mar 12.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1155/2013/483856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610394PMC
July 2013

Perspectives on the use of mesenchymal stem cells in vascularized composite allotransplantation.

Front Immunol 2013 23;4:175. Epub 2013 Jul 23.

Department of Plastic Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA , USA ; Division of Plastic and Hand Surgery, University Hospital Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2013.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719134PMC
July 2013

Effects of an interleukin-15 antagonist on systemic and skeletal alterations in mice with DSS-induced colitis.

Am J Pathol 2013 Jun 10;182(6):2155-67. Epub 2013 Apr 10.

Service of Bone Diseases, Department of Medical Specialties, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.033DOI Listing
June 2013

Molecular characterization and functional activity of an IL-15 antagonist MutIL-15/Fc human fusion protein.

Mol Pharm 2013 Feb 22;10(2):717-27. Epub 2013 Jan 22.

Biopharmaceutical Development Program, SAIC-Frederick, Inc. , Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.

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http://dx.doi.org/10.1021/mp300513jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573692PMC
February 2013

Hemiface allotransplantation in the mouse.

Plast Reconstr Surg 2012 Apr;129(4):867-70

Research Laboratory Innsbruck Medical University Anichstrasse 35 A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1097/PRS.0b013e3182450affDOI Listing
April 2012

Favoring the risk-benefit balance for upper extremity transplantation--the Pittsburgh Protocol.

Hand Clin 2011 Nov;27(4):511-20, ix-x

Pittsburgh Reconstructive Transplantation Program, Division of Plastic Surgery, Department of Surgery, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.hcl.2011.08.008DOI Listing
November 2011

Targeting uncoupling protein-2 improves islet graft function.

Cell Transplant 2011 18;20(3):421-9. Epub 2010 Aug 18.

Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.3727/096368910X522243DOI Listing
August 2011

Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice.

Arthritis Rheum 2010 Nov;62(11):3300-10

World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Medical School, and Geneva University Hospital, Geneva, Switzerland.

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http://dx.doi.org/10.1002/art.27645DOI Listing
November 2010

Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance.

J Immunol 2010 Oct 15;185(8):4750-9. Epub 2010 Sep 15.

Division of Plastic and Reconstructive Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1000769
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http://dx.doi.org/10.4049/jimmunol.1000769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766970PMC
October 2010

Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice.

Cytokine 2010 Sep 2;51(3):311-9. Epub 2010 Jul 2.

Division of Plastic Surgery, The Thomas E. Starzl Transplantation Institute, University of Pittsburgh WBST1557, 200 Lothrop Street, Pittsburgh, PA 15213, United States.

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http://dx.doi.org/10.1016/j.cyto.2010.06.007DOI Listing
September 2010

T regulatory cells and transplantation tolerance.

Transplant Rev (Orlando) 2010 Jul 11;24(3):147-59. Epub 2010 Jun 11.

Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.trre.2010.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902703PMC
July 2010

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.

Eur J Immunol 2009 Sep;39(9):2492-501

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/eji.200939274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759376PMC
September 2009

Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model.

Transplantation 2009 Jun;87(12):1769-77

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1097/TP.0b013e3181a664f1DOI Listing
June 2009

Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.

J Immunol 2009 Feb;182(3):1379-85

Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767978PMC
February 2009

[The effect of recombinant interleukin-10/Fc fusion protein on lipopolysaccharide-induced acute lung injury in mice].

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008 Aug;20(8):461-4

Medical and Health Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

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August 2008

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

J Clin Invest 2008 Feb;118(2):735-41

Division of Transplant Immunology and Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI32562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129234PMC
February 2008

Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection.

J Immunol 2008 Jan;180(1):113-21

Center for Biomedical Research, University of Texas Health Center, Tyler, TX 75708, USA.

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January 2008

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.

Proc Natl Acad Sci U S A 2007 Aug 1;104(32):13074-9. Epub 2007 Aug 1.

Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0705863104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941818PMC
August 2007

Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins.

Transplantation 2007 Jul;84(1 Suppl):S12-6

Division of Transplant Immunology, Harvard Medical School, and Transplant Research Center, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

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http://dx.doi.org/10.1097/01.tp.0000269111.87719.d8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791515PMC
July 2007

New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses.

Blood 2007 May 29;109(9):4071-9. Epub 2006 Dec 29.

Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2006-10-050625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874581PMC
May 2007

Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance.

Int Immunol 2006 Dec 26;18(12):1771-7. Epub 2006 Oct 26.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1093/intimm/dxl111DOI Listing
December 2006

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Nature 2006 Aug 20;442(7106):997-1002. Epub 2006 Aug 20.

Department of Microbiology & Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1038/nature05010DOI Listing
August 2006

Proteomic analysis of the allograft response.

Transplantation 2006 Jul;82(2):267-74

Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/01.tp.0000226254.89987.ecDOI Listing
July 2006

Specificity of CD4+CD25+ regulatory T cell function in alloimmunity.

J Immunol 2006 Jan;176(1):329-34

Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841032PMC
January 2006

An antagonist mutant IL-15/Fc promotes transplant tolerance.

Transplantation 2006 Jan;81(1):109-16

Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329733PMC
January 2006

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

Nat Immunol 2005 Dec 13;6(12):1245-52. Epub 2005 Nov 13.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ni1271DOI Listing
December 2005

Regulation of T cell dependent immune responses by TIM family members.

Philos Trans R Soc Lond B Biol Sci 2005 Sep;360(1461):1681-5

Department of Medicine, Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1098/rstb.2005.1706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569540PMC
September 2005

Requirements for induction and maintenance of peripheral tolerance in stringent allograft models.

Proc Natl Acad Sci U S A 2005 Sep 6;102(37):13230-5. Epub 2005 Sep 6.

Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0505070102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201597PMC
September 2005

Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol.

J Immunol 2005 Jul;175(1):51-60

Transplantation Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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July 2005

TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.

Nat Immunol 2005 May 27;6(5):455-64. Epub 2005 Mar 27.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ni1185DOI Listing
May 2005

CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance.

Am J Transplant 2005 May;5(5):978-86

Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, WA, USA.

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http://dx.doi.org/10.1111/j.1600-6143.2005.00823.xDOI Listing
May 2005

Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis.

J Immunol 2004 Nov;173(9):5818-26

Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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November 2004

The balance of deletion and regulation in allograft tolerance.

Immunol Rev 2003 Dec;196:75-84

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA.

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December 2003

Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

Nat Immunol 2003 Nov 12;4(11):1093-101. Epub 2003 Oct 12.

Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ni987DOI Listing
November 2003

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance.

Nat Immunol 2003 Nov 12;4(11):1102-10. Epub 2003 Oct 12.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ni988DOI Listing
November 2003

Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance.

Immunity 2003 Oct;19(4):503-14

Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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October 2003

Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15.

Adv Exp Med Biol 2003 ;520:87-95

Beth Israel Deaconess Medical Centre, Boston, Massachusetts, USA.

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July 2003

Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.

J Immunol 2002 Oct;169(7):3744-51

Department of Medicine, Children's Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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October 2002

The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression.

Transplantation 2002 Sep;74(6):898-900

Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://dx.doi.org/10.1097/01.TP.0000028779.24725.CFDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807859PMC
September 2002

On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response.

J Immunol 2002 May;168(9):4382-90

Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807814PMC
May 2002

Tracking the immunoregulatory mechanisms active during allograft tolerance.

J Immunol 2002 Mar;168(5):2274-81

Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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March 2002