Publications by authors named "Xin Xia"

318 Publications

Association of resting heart rate with cognitive decline and dementia in older adults: A population-based cohort study.

Alzheimers Dement 2021 Dec 3. Epub 2021 Dec 3.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

Introduction: Resting heart rate (RHR) predicts future risk for cardiovascular disease (CVD). However, longitudinal studies investigating the relationship of RHR with cognitive decline are scarce.

Methods: This population-based cohort study included 2147 participants (age≥60) in SNAC-K who were free of dementia and regularly followed from 2001-2004 to 2013-2016. RHR was assessed with electrocardiogram. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders 4th Revision criteria. Global cognitive function was assessed using Mini-Mental State Examination (MMSE). Data were analyzed using Cox and linear mixed-effects models.

Results: RHR≥80 (vs. 60-69) bpm was associated with a multi-adjusted hazard ratio of 1.55 (95% confidence interval 1.06-2.27) for dementia. The association remained significant after excluding participants with prevalent and incident CVDs. Similarly, RHR≥80 bpm was associated with a multi-adjusted β-coefficient of -0.13 (-0.21 to -0.04) for MMSE score.

Discussion: Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.
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http://dx.doi.org/10.1002/alz.12495DOI Listing
December 2021

Luminescent Hydrogel Based on Silver Nanocluster/Malic Acid and Its Composite Film for Highly Sensitive Detection of Fe.

Gels 2021 Oct 31;7(4). Epub 2021 Oct 31.

Key Laboratory of Colloid and Interface Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

Metal nanoclusters (NCs) with excellent photoluminescence properties are an emerging functional material that have rich physical and chemical properties and broad application prospects. However, it is a challenging problem to construct such materials into complex ordered aggregates and cause aggregation-induced emission (AIE). In this article, we use the supramolecular self-assembly strategy to regulate a water-soluble, atomically precise Ag NCs (NH)[Ag(CHSO)] (Ag-NCs, [Ag(mba)], Hmba = 2-mercaptobenzoic acid) and L-malic acid (L-MA) to form a phosphorescent hydrogel with stable and bright luminescence, which is ascribed to AIE phenomenon. In this process, the AIE of Ag-NCs could be attributed to the non-covalent interactions between L-MA and Ag-NCs, which restrict the intramolecular vibration and rotation of ligands on the periphery of Ag-NCs, thus inhibiting the ligand-related, non-radiative excited state relaxation and promoting radiation energy transfer. In addition, the fluorescent Ag-NCs/L-MA xerogel was introduced into polymethylmethacrylate (PMMA) to form an excellently fluorescent film for sensing of Fe. Ag-NCs/L-MA/PMMA film exhibits an excellent ability to recognize Fe ion with high selectivity and a low detection limit of 0.3 μM. This research enriches self-assembly system for enhancing the AIE of metal NCs, and the prepared hybrid films will become good candidates for optical materials.
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http://dx.doi.org/10.3390/gels7040192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628787PMC
October 2021

Impact of near-surface turbulence on PM concentration in Chengdu during the COVID-19 pandemic.

Atmos Environ (1994) 2022 Jan 11;268:118848. Epub 2021 Nov 11.

State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing, China.

The role of meteorological conditions has long been recognized in modulating regional air quality. The impact of near-surface turbulence, nevertheless, remains poorly understood. To curb the spread of COVID-19, a variety of lockdown measures were implemented, providing us an unprecedented opportunity to examine the joint impact of emission control and meteorology on regional air quality. Here we examined the variations of planetary boundary layer (PBL) height, PM concentrations, turbulence kinetic energy (TKE), vertical wind shear, and their associations in Chengdu, Sichuan province in Southwest China between January 13 and February 24, 2020, by synergistically using micro pulse lidar, ground-level meteorological and PM measurements, as well as ultrasonic anemometer observations. During the study period, Sichuan basin was primarily regulated by the straight west wind, with an averaged wind speed of 2-3 m/s at 850 hPa, indicative of a relatively stable atmospheric dispersion condition. TKE was positively correlated with PBL height but negatively correlated with PM. The PM concentration varied dramatically during pre- and post-lockdown periods but remained near constant at a relatively low level during the lockdown period. Meanwhile, the negative correlation between TKE and PM was much stronger during the lockdown and post-lockdown periods, when aerosol emissions were significantly reduced. Moreover, the correlation between TKE and PM exhibited large diurnal variability, with the strongest correlation observed during the daytime when solar radiation and turbulent mixing generally reached their peaks. Overall, the observational results in Chengdu underscore the non-negligible impact of turbulence on regional PM concentrations, which could help better understand the variation of regional air pollution events.
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http://dx.doi.org/10.1016/j.atmosenv.2021.118848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580557PMC
January 2022

Silmitasertib-induced macropinocytosis promoting DDP intracellular uptake to enhance cell apoptosis in oral squamous cell carcinoma.

Drug Deliv 2021 Dec;28(1):2480-2494

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Med-X Center for Materials, Sichuan University, Chengdu, China.

Cisplatin (DDP) is a first-line chemotherapeutic drug applied for the treatment of oral squamous cell carcinoma (OSCC). The anticancer activity of DDP is tightly linked to its intracellular uptake. It is unwise to increase the DDP intake by increasing the dose or shortening the dosing interval because of the severe systemic toxicity (nephrotoxicity, ototoxicity and neurotoxicity) in DDP application. The main uptake pathways of DDP include passive diffusion and active transporter transport. Therefore, finding additional uptake pathways that can improve the effective intracellular concentration of DDP is critical. Macropinocytosis, an endocytic mechanism for extracellular material absorption, contributes to the intracellular uptake of anticancer drugs. No research has been conducted to determine whether macropinocytosis can augment the intracellular uptake of DDP in OSCC cells or not. Based on that, we proved for the first time that silmitasertib (previously CX-4945) could trigger macropinocytosis, which may increase the intracellular uptake of DDP and enhance apoptosis via and experiments. We hope that our findings will inspire a new approach for the application of DDP in cancer treatment.
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http://dx.doi.org/10.1080/10717544.2021.2000677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592591PMC
December 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Albania.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B6-B8. Epub 2021 May 20.

Faculty of Medicine, University of Medicine, Rr. "Dibres", No. 371, Tirana, Albania.

This article discusses the results of the May Measurement Month (MMM) 2019 campaign, which contributed to a third round of MMM hypertension screening campaigns carried out in Albania, a transitional country in the Western Balkans. The hypertension screening campaign in Albania was carried out during the period 1-31 May 2019 in 30 sites in many districts of the country. Overall, 19 154 participants aged ≥18 years were included (approximately 68% of these were women), with an overall mean age of 47.0 ± 15.3 years. Blood pressure (BP) was measured with OMRON sphygmomanometers (Omron Healthcare, Kyoto, Japan). Hypertension was defined as systolic BP ≥140 mmHg, or diastolic BP ≥90 mmHg, or on treatment for hypertension. Self-reported data consisted of height and weight, pre-existing conditions, including smoking status and alcohol consumption. Overall, the proportion of participants with hypertension was 38.6%. Less than two-thirds (64.7%) of hypertensive individuals were aware of their condition. Also, less than half (48.3%) of participants on antihypertensive medication had controlled BP (<140/90 mmHg). The most sizable correlations of high BP were with known hypertension status, use of antihypertensive medication, and obesity. The MMM campaign contributes to routine hypertension screening in Albania. Hence, health professionals and policymakers in Albania should act on the findings of MMM screening campaigns and continue its support as a valuable tool for early detection of hypertension in the general population.
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http://dx.doi.org/10.1093/eurheartj/suab015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559333PMC
May 2021

Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System.

Pharmaceutics 2021 Oct 17;13(10). Epub 2021 Oct 17.

Department Drug Sciences, University of Pavia, Vle Taramelli 12, 27100 Pavia, Italy.

Oligonucleotide therapeutics such as miRNAs and siRNAs represent a class of molecules developed to modulate gene expression by interfering with ribonucleic acids (RNAs) and protein synthesis. These molecules are characterized by strong instability and easy degradation due to nuclease enzymes. To avoid these drawbacks and ensure efficient delivery to target cells, viral and non-viral vectors are the two main approaches currently employed. Viral vectors are one of the major vehicles in gene therapy; however, the potent immunogenicity and the insertional mutagenesis is a potential issue for the patient. Non-viral vectors, such as polymeric nanocarriers, provide a safer and more efficient delivery of RNA-interfering molecules. The aim of this work is to employ PLGA core nanoparticles shell-coated with chitosan oleate as siRNA carriers. An siRNA targeted on HIV-1, directed against the viral Tat/Rev transcripts was employed as a model. The ionic interaction between the oligonucleotide's moieties, negatively charged, and the positive surface charges of the chitosan shell was exploited to associate siRNA and nanoparticles. Non-covalent bonds can protect siRNA from nuclease degradation and guarantee a good cell internalization and a fast release of the siRNA into the cytosolic portion, allowing its easy activation.
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http://dx.doi.org/10.3390/pharmaceutics13101716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539707PMC
October 2021

Mesenchymal Stem Cells: Potential Therapeutic Prospect of Paracrine Pathways in Neonatal Infection.

J Interferon Cytokine Res 2021 10;41(10):365-374

Department of Neonatology, and Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.

Infection is the leading cause of admission and mortality in neonatal intensive care units. Immature immune function and antibiotic resistance make the treatment more difficult. However, there is no effective prevention for it. Recently, more and more researches are focusing on stem cell therapy, especially mesenchymal stem cells (MSCs); their potential paracrine effect confer MSCs with a major advantage to treat the immune and inflammatory disorders associated with neonatal infection. In this review, we summarize the basal properties and preclinical evidence of MSCs and explore the potential mechanisms of paracrine factors of MSCs for neonatal infection.
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http://dx.doi.org/10.1089/jir.2021.0094DOI Listing
October 2021

Correlation Between Prevalence of Selected Enteropathogens and Diarrhea in Children: A Case-Control Study in China.

Open Forum Infect Dis 2021 Oct 31;8(10):ofab445. Epub 2021 Aug 31.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: The application of nucleic acid detection methods improves the ability of laboratories to detect diarrheal pathogens, but it also poses new challenges for the interpretation of results. It is often difficult to attribute a diarrhea episode to the detected pathogens. Here we investigated the prevalence of 19 enteropathogens among diarrheal and nondiarrheal children and provided support for understanding the clinical significance of the pathogens.

Methods: A total of 710 fecal samples were collected from children under 5 years old in 2 different regions of China from May 2017 to March 2018, comprising 383 mild to moderate diarrheal cases and 327 nondiarrheal controls. The enteropathogens were detected using real-time polymerase chain reaction (PCR) or real-time reverse transcription PCR (RT-PCR).

Results: Enteropathogens were detected in 68.9% of cases and 41.3% of controls. Rotavirus A (adjusted OR [aOR], 9.91; 95% CI, 4.99-19.67), norovirus GI and GII (aOR, 3.82; 95% CI, 2.12-6.89), and (aOR, 20.12; 95% CI, 2.57-157.38) were significantly associated with diarrhea ( < .05). Adenovirus, norovirus GII, rotavirus A, and enteroaggregative (pCVD432) gave lower cycle threshold (Ct) values in cases than in controls ( < .05). Rotavirus A and norovirus GII were associated with diarrhea when the Ct values were ≤30 and ≤25, respectively.

Conclusions: The types and loads of enteropathogens are likely to influence the interpretation of the clinical significance of positive results.
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http://dx.doi.org/10.1093/ofid/ofab445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496764PMC
October 2021

RANBP1 promotes colorectal cancer progression by regulating pre-miRNA nuclear export via a positive feedback loop with YAP.

Oncogene 2021 Oct 6. Epub 2021 Oct 6.

Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.

Colorectal cancer (CRC) is among the top five most common malignant tumors worldwide and has a high mortality rate. Identification of the mechanism of CRC and potential therapeutic targets is critical for improving survival. In the present study, we observed high expression of RAN binding protein 1 (RANBP1) in CRC tissues. Upregulated RANBP1 expression was strongly associated with TNM stages and was an independent risk factor for poor prognosis. In vitro and in vivo functional experiments demonstrated that RANBP1 promoted the proliferation and invasion of CRC cells and inhibited the apoptosis of CRC cells. Low RANBP1 expression reduced the expression levels of hsa-miR-18a, hsa-miR-183, and hsa-miR-106 microRNAs (miRNAs) by inhibiting the nucleoplasmic transport of precursor miRNAs (pre-miRNAs), thereby promoting the accumulation of the latter in the nucleus and reducing the expression of mature miRNAs. Further experiments and bioinformatic analyses demonstrated that RANBP1 promoted the expression of YAP by regulating miRNAs and the Hippo pathway. We also found that YAP acted as a transcriptional cofactor to activate RANBP1 transcription in combination with TEAD4 transcription factor. Thus, RANBP1 further promoted the progression of CRC by forming a positive feedback loop with YAP. Our results revealed the biological role and mechanism of RANBP1 in CRC for the first time, suggesting that RANBP1 can be used as a diagnostic molecule and a potential therapeutic target in CRC.
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http://dx.doi.org/10.1038/s41388-021-02036-5DOI Listing
October 2021

Supramolecular Chirality from Hierarchical Self-Assembly of Atomically Precise Silver Nanoclusters Induced by Secondary Metal Coordination.

ACS Nano 2021 Oct 20;15(10):15910-15919. Epub 2021 Sep 20.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, People's Republic of China.

Chiral assembly of metal nanoparticles (NPs) into complex superstructures has been widely studied, but their formation mechanisms still remain mysterious due to the lack of precise structural information from the metal-organic interface to metallic kernel. As "molecular models" of metal NPs, atomically precise metal nanoclusters (NCs) used in the assembly of a macroscale superstructure will provide details of microscopic structure for deep understanding of such highly sophisticated assemblies; however, chiral superstructures have not been realized starting from achiral metal NCs with atomic precision. Herein, we report the supramolecular assembly of a water-soluble silver NC ((NH)[Ag(mba)], Hmba = 2-mercaptobenzoic acid, abbreviated as Ag-NCs hereafter) into chiral hydrogels induced by the coordination of secondary metal ions. Single crystal X-ray diffraction reveals the triskelion-like structure of Ag-NCs with a pseudochiral conformation caused by special arrangement of the peripheral mba ligands. The enantioselective orientation of the peripheral carboxyl group facilitates the assembly of Ag-NCs into nanotubes with a chiral cubic (*) lattice when coordinating to Ba. The nanotubes can further intertwine into one-dimensional chiral nanobraids with a preferred left-handed arrangement. These multiple levels of chirality can be tuned by drying, during which the * phase is missing but the chiral entanglement of the nanotubes is enhanced. Through the gelation of atomically precise, achiral NCs coordination of secondary metal ions, chiral amplification of superstructures was realized. The origination of the chirality at different length scales was also discussed.
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http://dx.doi.org/10.1021/acsnano.1c03824DOI Listing
October 2021

Comparative Proteomics at the Critical Node of Vigor Loss in Wheat Seeds Differing in Storability.

Front Plant Sci 2021 30;12:707184. Epub 2021 Aug 30.

National Crop Genebank, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.

The critical node (CN, 85% germination) of seed viability is an important threshold for seed regeneration decisions after long-term conservation. Dependent on the germplasm, the storage period until CN is reached varies and information on the divergence of the proteomic profiles is limited. Therefore, the study aims to identify key proteins and mechanisms relevant for a long plateau phase and a late CN during artificial seed aging of wheat. Seeds of the storage-tolerant genotype (ST) TRI 23248, and the storage-sensitive genotype (SS) TRI 10230 were exposed to artificial ageing (AA) and extracted embryos of imbibed seeds were analyzed using an iTRAQ-based proteomic technique. ST and SS required AA for 24 and 18 days to reach the CN, respectively. Fifty-seven and 165 differentially abundant proteins (DAPs) were observed in the control and aged groups, respectively. Interestingly, a higher activity in metabolic processes, protein synthesis, transcription, cell growth/division, and signal transduction were already found in imbibed embryos of control ST seeds. After AA, 132 and 64 DAPs were accumulated in imbibed embryos of both aged ST and SS seeds, respectively, which were mainly associated with cell defense, rescue, and metabolism. Moreover, 78 DAPs of ST appeared before CN and were mainly enriched in biological pathways related to the maintenance of redox and carbon homeostasis and they presented a stronger protein translation ability. In contrast, in SS, only 3 DAPs appeared before CN and were enriched only in the structural constituents of the cytoskeleton. In conclusion, a longer span of plateau phase might be obtained in seeds when proteins indicate an intense stress response before CN and include the effective maintenance of cellular homeostasis, and avoidance of excess accumulation of cytotoxic compounds. Although key proteins, inherent factors and the precise regulatory mechanisms need to be further investigated, the found proteins may also have functional potential roles during long-term seed conservation.
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http://dx.doi.org/10.3389/fpls.2021.707184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435634PMC
August 2021

EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma.

J Cell Mol Med 2021 09 4;25(17):8479-8489. Epub 2021 Aug 4.

The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.

Scutellarin, an active flavone extracted from Erigeron breviscapus, is known to exhibit antitumour activity in many cancers. However, the effects of Scutellarin on osteosarcoma remain unclear. In this study, we found that Scutellarin suppressed osteosarcoma cell growth, induced cell apoptosis and inhibited tumorigenesis. Mechanistically, our data revealed that EGR1 was significantly increased under Scutellarin treatment. Increased EGR1 enhanced tumour-suppressive effects of Scutellarin on osteosarcoma cells via transcriptionally downregulating LINC00857 expression. Additionally, we found that LINC00857 acted as a competitive endogenous RNA of miR-150-5p and inhibited the activity of miR-150-5p, which resulted in c-Myc increase. Scutellarin could suppress c-Myc protein levels through decreasing LINC00857 expression in osteosarcoma. Thus, these findings demonstrate that EGR1/ LINC00857/miR-150-5p/c-Myc axis plays a key role in promoting anticancer effects of Scutellarin and Scutellarin might have potential clinical implication in osteosarcoma clinical treatment.
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http://dx.doi.org/10.1111/jcmm.16809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419195PMC
September 2021

Follicular Regulatory T Cells in Systemic Lupus Erythematosus.

J Immunol Res 2021 13;2021:9943743. Epub 2021 Jul 13.

Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.

Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses. They can disrupt Tfh cell- and B cell-linked recognition, induce Tfh apoptosis, and suppress B cell function. Evidences show that dysregulated Tfr cells are associated with the disease activity index and serum autoantibody levels, influencing the development of systemic lupus erythematosus (SLE). This review focuses on the interaction among Tfr, Tfh, and B cells, summarizes the characterization and function of Tfr cells, concludes the imbalance of CD4T subsets in SLE, and presents potential therapies for SLE. In general, we discuss the roles of Tfr cells in the progress of SLE and provide potential treatments.
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http://dx.doi.org/10.1155/2021/9943743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294974PMC
July 2021

Electrocatalytic water oxidation by a water-soluble copper complex with a pentadentate amine-pyridine ligand.

Dalton Trans 2021 Aug 26;50(31):10888-10895. Epub 2021 Jul 26.

Jiangsu Laboratory of Advanced Functional Materials, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, P. R. China.

A water-soluble copper complex with a diamine-tripyridine ligand was synthesized successfully and well characterized. It was found to be catalytically active for the water oxidation reaction under basic conditions. Based on the electrochemical test result, this copper complex displayed an apparent rate constant (k) of 0.81 s for the oxygen evolution reaction in 0.1 M phosphate buffer solution at pH 11.0. More importantly, the copper complex remained stable over 3 h of a bulk electrolysis experiment at 1.60 V with a Faradaic efficiency of 90.7% for O evolution, and the decrement of current density was only 1.9%. These results suggest that the pentadentate copper complex is an efficient and durable homogeneous Earth-abundant electrocatalyst for water oxidation.
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http://dx.doi.org/10.1039/d1dt01821cDOI Listing
August 2021

[Selection and application in the approach of Bonebridge implantation for bilateral congenital malformation of external and middle ear: selection and application].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):602-607

Department of Otorhinolaryngology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China.

According to whether auricle reconstruction has been performed before the implantation of Bonebridge, the different surgical plan of combination of ear reconstruction and hearing rehabilitation with Bonebridge were respectively applied for the individuals with congenital outer and middle ear malformation. The study aim to explore the feasibility of personalized comprehensive treatment of congenital outer and middle ear malformation. We developed individualized surgical plans of Bonebridge implantation and auricular reconstruction for 35 patients with bilateral external and middle ear malformation. Six patients underwent Bonebridge implantation on one side, and the post-auricular skin expander implantation on the other sidesimultaneously; seven patients underwent Bonebridge implantation at the same time as the second stage of auricular reconstruction; twenty-two patients had their Bonebridge implantations performed after the reconstruction of the auricles. No intraoperative complications occured in 35 patients. No facial paralysis, vertigo, tinnitus and cerebrospinal fluid leakage was reported. One patient had skin infection after Bonebridge implantation. The Bonebridge was removed and 7 months later and the Bonebridge implantation was re-performed on the same side. No complication occurred after 16 months of follow-up. According to the individual condition of the patients, different surgical plans of Bonebridge implantation and auricular reconstruction can be selected personally, which is beneficial to obtain the ideal aesthetic and hearing outcome.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.07.006DOI Listing
July 2021

Tracheal window resection and reconstruction via sternocleidomastoid flap for invasive thyroid carcinoma.

Interact Cardiovasc Thorac Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objectives: The aim of this study was to present surgical techniques and evaluate outcomes of a sternocleidomastoid muscle (SCM) myoperiosteal flap used for the reconstruction of tracheal or laryngotracheal defects after the radical resection of invasive thyroid carcinoma.

Methods: A retrospective study was performed for patients at Peking Union Medical College Hospital from January 2008 to December 2018 of papillary thyroid carcinoma with tracheal or laryngotracheal invasion. Patients were enrolled only when they received window resection and reconstruction via an SCM myoperiosteal flap. The primary outcome was a stable airway, and the secondary outcome was survival.

Results: A total of 15 invasive thyroid carcinoma patients were enrolled in this study. Laryngotracheal and tracheal reconstruction were performed in 11 and 4 patients respectively, with a median vertical defect of 3.5 cm (3.0, 4.5). A stable airway was achieved in 14 patients postoperatively. One patient experienced tracheal stenosis and received a second operation of tracheal sleeve resection and end-to-end anastomosis 105 days after the first operation. Tracheostomy was conducted in 5 out of 15 patients in whom the vertical defects were larger than 4 cm, and the tubes were extubated after a median time of 56 days (32, 84). The median observation time was 55 months (48, 86), and all 15 patients achieved a stable airway and showed no evidence of local recurrence at the end of follow-up.

Conclusions: For thyroid carcinoma with tracheal or laryngotracheal invasions, window resection with the SCM myoperiosteal flap reconstruction presented positive results in terms of a stable airway as well as oncological outcomes. The SCM myoperiosteal flap can be an appropriate reconstruction strategy, especially when the defects reach the thyroid cartilage.
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http://dx.doi.org/10.1093/icvts/ivab193DOI Listing
July 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Poland.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B124-B127. Epub 2021 May 20.

Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Oleska 48, 45-052 Opole, Poland.

May Measurement Month 2019 is the third edition of a global initiative organized by the International Society of Hypertension aimed at raising awareness of hypertension and the need for blood pressure (BP) screening. We present data analysis from Poland. To evaluate the potential of opportunistic BP measurements as a tool for cardiovascular disease prevention programmes. To collect new country data for further annual comparisons. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in 201 sites in May 2019. BP was measured in 7072 subjects (mean age: 54 ± 15 years; 62.3% females). After multiple imputation, the age- and sex-standardized systolic BP (SBP) and diastolic BP (DBP) was 125.4/78.5 mmHg in the whole group, 133.3/82.8 mmHg in individuals on antihypertensive medication and 123.3/77.7 mmHg in those not taking antihypertensive drugs. The proportion of subjects with high BP (≥140/90 mmHg) were 41.8% in subjects taking antihypertensive drugs, and 19.6% in those not taking any antihypertensive drugs. Overall, hypertension was present in 55.4% of participants (3917 out of 7072), of whom 83.0% were aware of their diagnosis. 80.4% of hypertensives were taking antihypertensive medication. 46.7% of all hypertensives had BP controlled to target (<140/90 mmHg). Higher BP correlated with body mass index and age but not tobacco smoking. SBP but not DBP was higher in diabetic participants. These data provide evidence on the current epidemiology of hypertension and may serve as a source of information to introduce primary and secondary prevention programmes to reduce cardiovascular risk in Poland.
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http://dx.doi.org/10.1093/eurheartj/suab045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263086PMC
May 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Italy.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B77-B81. Epub 2021 May 20.

Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, Milan 20149, Italy.

Cardiovascular (CV) diseases are burdened by high mortality and morbidity, being responsible for half of the deaths in Europe. Although hypertension is recognized as the most important CV risk factor, hypertension awareness, and blood pressure (BP) control are still unsatisfactory. In 2017 and 2018, respectively >10 000 and >5000 individuals took part in the May Measurement Month (MMM) campaign in Italy, of whom 30.6% and 26.3% were found to have high BP, respectively. To raise public awareness on the importance of hypertension and to collect BP data on a nation-wide scale in Italy. In the frame of the MMM campaign, an opportunistic cross-sectional survey of volunteers aged ≥18 years was carried out in May 2019. BP measurement, the definition of hypertension, and statistical analysis followed the standard MMM protocol. Screening was conducted in multiple sites by health personnel. Among the 10 182 people screened (females: 52.3%, mean age 58 ± 16years) mean BP was 127/78 mmHg, and 3171 (31.1%) participants had arterial hypertension, of whom 62.1% were aware of being hypertensive. Diabetes, body mass index >25 kg/m were associated with higher BP and previous myocardial infarction with lower BP. For the third consecutive year we collected a nation-wide snapshot of BP control in a large sample of individuals. The high participation, with some yearly fluctuations likely due to the limitations of the sampling technique, confirms the power of this kind of health campaign in reaching a significant number of people to raise awareness on health topics.
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http://dx.doi.org/10.1093/eurheartj/suab054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263076PMC
May 2021

From Normal Cognition to Cognitive Impairment and Dementia: Impact of Orthostatic Hypotension.

Hypertension 2021 Sep 6;78(3):769-778. Epub 2021 Jul 6.

Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet-Stockholm University, Sweden (X.X., R.W., D.L.V., G.G., E.J.L., M.D., L.F., C.Q.).

[Figure: see text].
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357050PMC
September 2021

May Measurement Month 2019: an analysis of blood pressure screening results from the Democratic Republic of the Congo.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B52-B54. Epub 2021 May 20.

Hypertension Unit/Cardiology, Department of internal medicine, University of Kinshasa Hospital, University of Kinshasa, Kinshasa, DR Congo.

Hypertension, the foremost cause of global morbi-mortality, is linked with a high mortality from numerous cardiovascular endpoints. The May Measurement Month (MMM) campaign is an annual initiative of the International Society of Hypertension (ISH) to collect information on blood pressure (BP) and other risk factors for cardiovascular disease (CVD) in adults. MMM2019 in the Democratic Republic of the Congo (DRC) was an opportunistic cross-sectional survey of volunteers aged ≥18 years that took place in Kinshasa and Mbuji-Mayi after the training of observers to familiarize with the ISH methods. We screened 29 857 individuals (mean age: 40 years; 40% female). Hypertension was present in 7624 (25.5%) individuals. Of them, 2520 (33.1%) were aware, 1768 (23.2%) on treatment with 910 (51.5%) controlled BP (systolic BP <140 mmHg and/or diastolic BP <90 mmHg). Of all hypertensives screened, 11.9% had controlled BP. Of all respondents, 16.7% had participated in MMM18 and 60.5% did not have their BP verified during the last year. Fasting, pregnancy, and underweight status were linked with lower BP levels whilst smoking, drinking, antihypertensive medication, previous stroke, diabetes as well as being overweight/obese were associated with higher BP levels. Our results reflect the high rate of hypertension in the DRC with low levels of awareness, treatment, and control. A nationally representative sample is required to establish the nationwide hypertension prevalence.
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http://dx.doi.org/10.1093/eurheartj/suab050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248957PMC
May 2021

May Measurement Month 2019: blood pressure screening results from Chile.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B40-B42. Epub 2021 May 20.

Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, London W12 7RH, UK.

Hypertension is a major preventable cause of death worldwide. May Measurement Month (MMM) is a global initiative aimed at raising awareness of high blood pressure (BP) and identifying individuals with increased BP. A cross-sectional survey of volunteers aged ≥18 years old was carried out in May 2019 in Chile. Participating sites were distributed across the country, most of them from the Public Health System outpatient clinics. In addition, clinical research sites, universities, and private clinics participated. Blood pressure measurement protocol, hypertension categories, and statistical analysis followed the MMM protocol. Hypertension was diagnosed as mean systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg or receiving antihypertensive medication. Overall, 6876 individuals were screened. After multiple imputations, hypertension prevalence was 35.4%, of which 65.9% were aware of their condition. While 60.1% were on antihypertensive medication and 34.4% of the total number of hypertensives had their BP controlled. Of participants not receiving antihypertensive treatment, 17.9% were identified as hypertensive. The MMM 2019 survey demonstrated a high proportion of participants with hypertension, with only one-third of these individuals having controlled BP (systolic BP <140 mmHg and diastolic BP <90 mmHg). The high percentage of participants with hypertension who were either untreated (39.9%) or were treated but uncontrolled (57.2%) suggesting that such opportunistic screening programmes may be a useful tool to improve hypertension control in Chile.
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http://dx.doi.org/10.1093/eurheartj/suab020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248933PMC
May 2021

Mid-Upper Arm Circumference as an Alternative Screening Instrument to Appendicular Skeletal Muscle Mass Index for Diagnosing Sarcopenia.

Clin Interv Aging 2021 15;16:1095-1104. Epub 2021 Jun 15.

Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Purpose: Mid-upper arm circumference (MUAC) is a simple, noninvasive anthropometric indicator. This study evaluated the applicability of MUAC as an alternative screening instrument to appendicular skeletal muscle mass index (ASMI) for detecting sarcopenia, and determined the optimal MUAC cutoff values.

Patients And Methods: A total of 4509 subjects ≥50 years of age from the West China Health and Aging Trend study were included in the present study. ASM was measured by bioelectrical impedance analysis. MUAC, calf circumference (CC), and grip strength were evaluated and the Short Physical Performance Battery and 3-m timed up-and-go test were administered. Low muscle mass was diagnosed based on Asian Working Group for Sarcopenia 2019 (AWGS2019) and updated European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria.

Results: ASMI was positively correlated with MUAC in both men (r=0.726, P<0.001) and women (r=0.698, P<0.001). The area under the receiver operating characteristic curve (AUC) for MUAC as an indicator of low muscle mass in men and women was 0.86 (95% confidence interval [CI]: 0.85-0.88) and 0.85 (95% CI: 0.84-0.86), respectively, according to AWGS2019 criteria; and 0.86 (95% CI: 0.85-0.88) and 0.86 (95% CI: 0.85-0.88), respectively, according to EWGSOP2 criteria. Optimal MUAC cutoff values for predicting low muscle mass were ≤28.6 cm for men and ≤27.5 cm for women. There was no significant difference between the AUCs of MUAC and CC in men according to the 2 reference standards (P=0.809), whereas the AUC of CC was superior to that of MUAC in women according to AWGS2019 (P<0.001) and EWGSOP2 (P=0.008) criteria.

Conclusion: MUAC is strongly correlated with ASMI among community-dwelling middle-aged and older adults in China. MUAC can be used as a simple screening instrument to ASMI for diagnosing sarcopenia, especially in men.
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http://dx.doi.org/10.2147/CIA.S311081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214542PMC
July 2021

Effects of a pneumatic tube system on the hemolysis of blood samples: a PRISMA-compliant meta-analysis.

Scand J Clin Lab Invest 2021 Sep 10;81(5):343-352. Epub 2021 Jun 10.

Nursing Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Many studies have explored how using a pneumatic tube system (PTS) is related to the hemolysis of blood samples, but their conclusions have been inconsistent. This meta-analysis was to clarify whether using a PTS induces the hemolysis of blood samples. The PubMed, Embase, Scopus, CNKI, CqVip, SinoMed and WanFang databases were searched for studies published between January 1970 and August 2019. The primary outcomes were the hemolysis rate and hemolysis index of blood samples after applying a PTS and manual transportation. We estimated the pooled risk ratio (RR) and the standardized mean difference (SMD), using random-effects models. This meta-analysis included 29 studies covering 3121 blood samples. No significant differences were found between the PTS and manual-transportation groups in the hemolysis rate [RR: 0.99, 95% confidence interval (CI): 0.57 to 1.70], hemolysis index (SMD: 0.19, 95% CI: -0.00 to 0.38), or level of potassium (SMD: 0.05, 95% CI: -0.03 to 0.12), alanine aminotransferase (SMD: 0.00, 95% CI: -0.10 to 0.11), or aspartate aminotransferase (SMD: 0.04, 95% CI: -0.08 to 0.17). However, lactate dehydrogenase (LDH) level was significantly higher in the PTS group than in the manual-transportation group (SMD: 0.20, 95% CI: 0.06 to 0.34). Subgroup analysis revealed that the LDH level was clearly higher in the PTS group than in the manual-transportation group only when the PTS speed was ≥6 m/s or when the PTS distance was ≥250 m. According to this meta-analysis, PTSs were associated with alterations in LDH measurements, so it is sensible that each hospital validates and monitors their PTSs.
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http://dx.doi.org/10.1080/00365513.2021.1930140DOI Listing
September 2021

A meta-analysis of the comparison of phlebitis between midline catheters and peripherally inserted central catheters in infusion therapy.

Int J Nurs Pract 2021 Jun 1:e12976. Epub 2021 Jun 1.

Department of Nursing, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Aims: To compare the risk of phlebitis between midline catheters and peripherally inserted central catheters in infusion therapy with a meta-analysis.

Design: This was a systematic literature review and meta-analysis.

Data Sources: Web of Science, PubMed, Scopus, Embase, Cochrane Library, ProQuest, CNKI, WanFang, VIP and SinoMed were searched from inception to May 2020.

Review Methods: All studies comparing the risk of phlebitis between midline catheters and peripherally inserted central catheters were included. According to the inclusion and exclusion criteria, two authors independently assessed the literature and extracted the data. Meta-analyses were conducted to generate estimates of phlebitis risk in patients with midline catheters verse peripherally inserted central catheters, and publication bias was evaluated with RevMan 5.3.

Results: A total of seven studies were collected, involving 1377 participants. The incidence of phlebitis with midline catheters and peripherally inserted central catheters was 1.52% and 3.41%. Meta-analysis showed that the incidence of phlebitis has no significant difference between midline catheters and peripherally inserted central catheters. The sensitivity analysis shows that the results from this meta-analysis are fair in overall studies. All studies have no significant publication bias.

Conclusion: This study provides the first systematic assessment of the risk of phlebitis between midline catheters and peripherally inserted central catheters. The incidence of phlebitis has no significant difference between them. There are many factors to consider when choosing vascular access devices.
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http://dx.doi.org/10.1111/ijn.12976DOI Listing
June 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Nepal.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B110-B113. Epub 2021 May 20.

Nepal Development Society, Bharatpur-10, Chitwan 44200, Nepal.

May Measurement Month (MMM) is a global initiative to screen high blood pressure (BP) in the community and increase awareness at the population level. High BP is the leading risk factor for mortality worldwide and in Nepal. This study presents the results of the 2019 MMM in Nepal. Opportunistic BP screening was conducted in 30 out of 77 districts across Nepal and aged ≥18 years at the community and public places. BP was measured three times in a seated position. A total of 74 205 individuals participated in the study, mean age 39.9 years, and 58% were male. BP measurements for the second and third readings were available for 69 292 (93.3%) individuals. The proportion of the population that were hypertensive was 27.5% ( = 20 429). Among those hypertensives, 46.3% were aware of their hypertensive status and of these, 37.5% were on antihypertensive medication. Only 54.3% of those on antihypertensive medication had their BP controlled. Of the community screened, those self reporting to have diabetes, current tobacco users, and current alcohol drinkers were 6.7%, 23.6%, and 31.9%, respectively; 20.6% of the participants were overweight, and 6.5% were obese. Since the first BP screening campaign, MMM 2017 in Nepal, the number of participants screened has largely increased over the years. MMM's success in Nepal is through a coordinated mobilization of trained health science students and volunteers in the communities. The Nepal MMM data demonstrates that large community-based BP screening campaigns are possible in low resource settings.
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http://dx.doi.org/10.1093/eurheartj/suab042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141957PMC
May 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Malawi.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B95-B97. Epub 2021 May 20.

Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, London W12 7RH, UK.

May Measurement Month (MMM) is a global initiative that aims at raising awareness and screening people for high blood pressure (BP). Malawi has participated in MMM since 2017. A 2017 STEPwise Survey conducted in Malawi among 4187 participants found that 65.2% had never had their BP measured before, 26.8% had their BPs measured but not diagnosed, 3.9% were diagnosed but not within the last 12 months, and 4.1% were diagnosed within the last 12 months. An opportunistic cross-sectional survey of volunteers aged 18 and above was carried out in May and June 2019. All BP measurements, definition of hypertension and statistical analysis followed the standard MMM protocol. The screening took place in Nkhatabay, Lilongwe, and Blantyre. A total number of 9723 participants were screened with a mean age of 42.0 (SD 16.6) years. Of these 8444 (86.8%) had never had their BP measured within the last 12 months, 2559 (26.3%) had raised BP, 2169 (23.2%) of those with raised BP were not on treatment whereas 390 (4.0%) were on treatment. The results showed that many of the participants had not had their BP checked in the past year. There is a significant need to expand BP screening opportunities within Malawi for early detection of hypertension.
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http://dx.doi.org/10.1093/eurheartj/suab041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141948PMC
May 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Kenya.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B86-B88. Epub 2021 May 20.

Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, London W12 7RH, UK.

Elevated blood pressure (BP) is the leading cause of global mortality, but control rates remain poor because most patients, especially in Africa, are unaware. May Measurement Month (MMM) is an annual global BP screening campaign that was initiated by the International Society of Hypertension (ISH) in 2017 to raise awareness of raised BP. Following participation in 2017 and 2018, Kenya participated again in 2019 and the results are reported here. Screening was carried out in 30 sites by volunteers coordinated by the Kenya Cardiac Society. Participants had three BP readings by standard methods with the last two being averaged and recorded. Heart rate, weight, height, socio-demographic parameters, and co-morbidities were documented. Hypertension was defined as a systolic BP (SBP) ≥140 mmHg and/or a diastolic BP (DBP) ≥90 mmHg or being on treatment with at least one antihypertensive medication. A total of 33 992 participants were screened, mean age was 42.5 (SD 16.8) years and 58.7% of participants were female. Only 27.3% had their BPs checked within the preceding 12 months. After multiple imputation, 26.1% were hypertensive, of whom 34.5% were aware of their hypertension and 31.5% were on treatment. Of those on treatment, 59.7% were controlled translating to 18.8% of all hypertensives. Being on treatment for hypertension, overweight, obese or having had hypertension in previous pregnancy were associated with increased SBP and DBP, while diabetes was associated with raised SBP. Two-thirds of hypertensives were unaware. Only a third of those aware were on treatment, with about 60% of these controlled. Lack of awareness remains a significant barrier to BP control. Programmes to raise awareness such as MMM are significant in raising population awareness.
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http://dx.doi.org/10.1093/eurheartj/suab040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141946PMC
May 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Brazil.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B30-B32. Epub 2021 May 20.

Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, London W12 7RH, UK.

The aim of this study is to describe the results of the May Month Measurement (MMM) campaign implemented in Brazil, in 2019. Questionnaire data were collected and three measures of blood pressure (BP) were performed. The sample consisted of 13 476 individuals, 58.2% were white, 60.8% were women. The average age was 46.3 (18.6) years. Of all 13 476 participants, 6858 (50.9%) had hypertension defined as a systolic BP ≥140 mmHg or a diastolic BP ≥90 mmHg or being on anti-hypertensive medication. Of those with hypertension, 68.8% were aware of their diagnosis, 65.3% were on antihypertensive medication, and 36.1% had controlled BP (<140/90 mmHg). In addition, of 4479 participants on anti-hypertensive medication, 55.2% had controlled BP. The use of anti-hypertensive medication was associated with higher systolic ( < 0.001) and diastolic BP ( < 0.001) and having diabetes with higher systolic BP ( < 0.001). Previous hypertension in pregnancy was associated with higher systolic ( = 0.038) and diastolic BP ( = 0.003), and smoking was associated with higher systolic BP ( < 0.001). Lastly, obese and overweight individuals showed significantly higher systolic ( < 0.001) and diastolic ( < 0.001) BP. The Brazilian MMM19 data demonstrate that strategies to increase awareness of hypertension and a better control of the risk factors are still needed.
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http://dx.doi.org/10.1093/eurheartj/suab019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8153193PMC
May 2021

May Measurement Month 2019: an analysis of blood pressure screening results from Botswana.

Eur Heart J Suppl 2021 May 20;23(Suppl B):B27-B29. Epub 2021 May 20.

Department of Family Medicine & Public Health, University of Botswana, Plot 4775 Corner Notwane & Mobuto Road, Gaborone, Botswana.

The May Measurement Month (MMM) 2019 campaign aimed to raise awareness of the health issues surrounding raised blood pressure (BP) among the general public. It also sought to identify and facilitate reduction of BPs of participants who require intervention to lower their BP according to current country treatment guidelines. Participants aged ≥18 years were recruited on site through interactions with the study team, educational fliers, and as voluntary walk-ins in response to the media engagement prior to the campaign. Blood pressures were measured using validated upper-arm cuff electronic devices provided by Omron Healthcare in partnership with International Society of Hypertension. With the participant seated, their back supported and legs resting uncrossed on the ground, three BP and heart rate readings were taken and recorded, 1 min apart. Participants' basic demographic data were also collected. Hypertension was defined as being on treatment for hypertension, or a systolic BP ≥140 mmHg and/or a diastolic BP ≥90 mmHg (based on the mean of the last two of three readings). Of the 5459 screened participants, 1750 (32.1%) had hypertension, of whom 784 (44.8%) were aware they were hypertensive and 726 (41.5%) were on antihypertensive medication. Among those on antihypertensive treatment, 47.0% had their BP controlled (<140/90 mmHg). Only 19.5% of all those with hypertension had their BP controlled. A total of 1024 (21.6%) of the 4733 participants not on antihypertensive treatment were hypertensive. Intensified preventive and treatment measures to control BP at the health system, individual and population levels remain a critical requirement for Botswana.
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http://dx.doi.org/10.1093/eurheartj/suab049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141947PMC
May 2021
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