Publications

Single cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.
Hepatology 2018 Jan 9. Epub 2018 Jan 9.
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892.


miR-29a promotes hepatitis B virus replication and expression by targeting SMARCE1 in hepatoma carcinoma.
World J Gastroenterol 2017 Jul;23(25):4569-4578
Hong-Jie Wu, Ya Zhuo, Yan-Cai Zhou, Xin-Wei Wang, Yan-Ping Wang, Chang-Yun Si, Xin-Hong Wang, Department of Infectious Disease, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan Province, China.

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.
Gastroenterology 2017 Apr 10;152(5):1161-1173.e1. Epub 2016 Dec 10.
RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts; Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address:

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.
Cancer Cell 2016 Oct;30(4):533-547
Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis.
Cancer Cell 2016 Sep 25;30(3):444-458. Epub 2016 Aug 25.
Liver Cancer Institute, Fudan University, Shanghai 200032, China; Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Science, Fudan University, Shanghai 200032, China. Electronic address:

Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.
Hepatology 2015 Sep 30;62(3):829-40. Epub 2015 Jun 30.
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

Regulatory MiR-148a-ACVR1/BMP circuit defines a cancer stem cell-like aggressive subtype of hepatocellular carcinoma.
Hepatology 2015 Feb;61(2):574-84
Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China.

Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
Bioinformatics 2015 Jan 18;31(2):216-24. Epub 2014 Sep 18.
Department of Medicine I, University of Regensburg, 93053, Regensburg, Department of Medicine I, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, 55131, Mainz, Department of Pathology, University of Heidelberg, 69120, Germany and Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, 20892 MD, USA.

Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.
PLoS Med 2014 Dec 23;11(12):e1001770. Epub 2014 Dec 23.
Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Kleberg Center for Molecular Markers, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.

Template-free synthesis and mechanistic study of porous three-dimensional hierarchical uranium-containing and uranium oxide microspheres.
Chemistry 2014 Sep 14;20(39):12655-62. Epub 2014 Aug 14.
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology and Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China), Fax: (+86) 10-88235294.

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.
Proc Natl Acad Sci U S A 2014 Jul 23;111(27):9905-10. Epub 2014 Jun 23.
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

Development of a novel filter cartridge system with electropositive granule media to concentrate viruses from large volumes of natural surface water.
Environ Sci Technol 2014 Jun 6;48(12):6947-56. Epub 2014 Jun 6.
Department of Environment and Health, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety , Tianjin 300050, China.

Seroprevalence and evolutionary dynamics of genotype 4 hepatitis E virus in Shandong Province, China.
World J Gastroenterol 2014 Jun;20(24):7955-63
Dong Yang, Min Jin, Zhi-Gang Qiu, Zhi-Qiang Shen, Da-Ning Wang, Xin-Wei Wang, Jun-Wen Li, Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China.

Sympathetic nerve innervation in cervical posterior longitudinal ligament as a potential causative factor in cervical spondylosis with sympathetic symptoms and preliminary evidence.
Med Hypotheses 2014 May 5;82(5):631-5. Epub 2014 Mar 5.
Department of Orthopaedic Surgery, Changzheng Hospital of the Second Military Medical University, Shanghai 200003, China. Electronic address:

Molecular characteristics and evolutionary analysis of field Marek's disease virus prevalent in vaccinated chicken flocks in recent years in China.
Virus Genes 2013 Oct 29;47(2):282-91. Epub 2013 Jun 29.
College of Veterinary Medicine, Jilin University, No. 5333 Xi'an Road, Changchun, 130062, Jilin, People's Republic of China.

Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.
Clin Cancer Res 2013 Jul 29;19(14):3944-54. Epub 2013 May 29.
Liver Cancer Institute and Zhongshan Hospital, Institutes of Biomedical Science, Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.

microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma.
Int J Cancer 2013 Jun 17;132(12):2901-9. Epub 2012 Dec 17.
Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.
Gastroenterology 2013 May 31;144(5):1066-1075.e1. Epub 2013 Jan 31.
Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.



Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.
J Immunol 2012 Jun 21;188(12):6055-62. Epub 2012 May 21.
Gastrointestinal Malignancy Section, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.




The 40-80 nt region in the 5'-NCR of genome is a critical target for inactivating poliovirus by chlorine dioxide.
J Med Virol 2012 Mar;84(3):526-35
Department of Environment and Health, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment and Food Safety, Tianjin, China.

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Cancer Cell 2011 Oct;20(4):487-99
Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice.
Cancer Lett 2011 Sep 23;308(1):14-22. Epub 2011 May 23.
Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, Tianjin, PR China.

Vitamin E modulates cigarette smoke extract-induced cell apoptosis in mouse embryonic cells.
Int J Biol Sci 2011 31;7(7):927-36. Epub 2011 Jul 31.
Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, No.1, Dali Road, Tianjin 300050, P. R. China.

Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma.
Int J Biol Sci 2013 16;9(3):303-12. Epub 2013 Mar 16.
Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

iSubgraph: integrative genomics for subgroup discovery in hepatocellular carcinoma using graph mining and mixture models.
PLoS One 2013 4;8(11):e78624. Epub 2013 Nov 4.
Department of Computer Science, University of Maryland, College Park, Maryland, United States of America ; Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

Enhancing mucosal immunity in mice by recombinant adenovirus expressing major epitopes of porcine circovirus-2 capsid protein delivered with cytosine-phosphate-guanosine oligodeoxynucleotides.
J Vet Sci 2014 21;15(3):399-407. Epub 2014 Mar 21.
Animal Infectious Disease Lab, College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China.


Effect of Endolymphatic Hydrops on Sound Transmission in Live Guinea Pigs Measured with a Laser Doppler Vibrometer.
Neural Plast 2016 14;2016:8648297. Epub 2016 Dec 14.
Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai 200031, China; Shanghai Auditory Medical Center, Shanghai, China; Key Laboratory of Hearing Science, Ministry of Health, Shanghai, China.

Efficient replication of blood-borne hepatitis C virus in human fetal liver stem cells.
Hepatology 2017 10 26;66(4):1045-1057. Epub 2017 Aug 26.
Department of Environment and Health, Tianjin Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, Tianjin, China.

OF