Publications by authors named "Xin Kang"

158 Publications

Electrochemical Cyclization of Alkynyl Enaminones: Controllable Synthesis of Indeno[1,2-]pyrroles or Indanones.

J Org Chem 2022 Aug 4. Epub 2022 Aug 4.

Shandong Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

We report an electrochemical intramolecular [3 + 2] cyclization of alkynyl enaminones in a user-friendly undivided cell under constant current conditions without an oxidant and catalyst, and indeno[1,2-]pyrrole derivatives could be obtained in good to excellent yields. Notably, preliminary substituent-controlled selective transformation is also achieved under electrocatalysis alone, and indeno[1,2-]pyrrole (R ≠ H) or indanone derivatives (R = H) could be prepared directly under electrocatalysis without adding a base and heating process.
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http://dx.doi.org/10.1021/acs.joc.2c01373DOI Listing
August 2022

A cross-cultural study of visual attention in autism spectrum disorder.

Child Neuropsychol 2022 Jul 29:1-32. Epub 2022 Jul 29.

Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.

Differences in visual attention have been documented in ASD, and appear linked to clinical symptoms. However, most research has been conducted in Western cultures. Because striking differences in visual attention patterns have been documented in other cultures, it is important to understand how culture may influence attentional patterns in ASD. This study compared differences in visual attention in ASD across Western and East Asian cultures, where differences in attention to contextual and global information have been repeatedly demonstrated, to investigate potential culturally-specific ASD phenotypes. One hundred thirty-two total participants included individuals with ASD ( = 24) and controls ( = 47) from Hong Kong (HK), along with a previously studied group of age- and IQ-comparable participants from the United States ( = 26 ASD;  = 35 control). Gaze was tracked while participants completed two narrative tasks that differed in social-emotional complexity. Proportions of fixations to face, bodies, and setting were examined across groups using linear mixed-effect models and a series of growth curve models. Cultural differences were found across tasks and groups. Both the ASD and control HK groups attended more to global contextual setting information, more to the body regions, and less toward faces of characters compared to US groups. Growth curve models indicated that these differences attenuated over time in certain stimuli. ASD-related effects were only observed in the more complex stimuli depicting characters with ambiguous facial expressions. Findings indicate a notable cultural influence on visual attention patterns in ASD, and underscore the importance of stimuli complexity in differentiating cultural versus diagnostic effects on attentional styles.
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http://dx.doi.org/10.1080/09297049.2022.2094904DOI Listing
July 2022

Eradication and graft retention can be achieved in the treatment for acute septic arthritis after primary posterior cruciate ligament reconstruction: analysis of 1561 reconstructions.

Knee Surg Sports Traumatol Arthrosc 2022 Jul 11. Epub 2022 Jul 11.

Sports Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.

Purpose: Acute septic arthritis after arthroscopic posterior cruciate ligament (PCL) reconstruction is a rare but severe complication. Optimal management has not been established. The purposes of this study were to analyze clinical findings and to retrospectively evaluate the graft-retaining treatment regimen.

Methods: From 2010 to 2021, a total of 1561 primary PCL reconstructions were performed at our institution. Seven patients with septic arthritis were identified and retrospectively analyzed with regard to incidence, clinical manifestations, treatment, postoperative clinical course and follow-up results.

Results: The mean interval from PCL reconstruction to the onset of symptoms was 11.0 ± 4.0 days. Staphylococcus aureus was the most commonly found pathogen. Eradication was achieved in all patients after a mean of 1.1 ± 0.4 procedures, with graft retention in all patients. The mean duration of antibiotic treatment was 5.7 ± 1.5 weeks. At the last follow-up, there was no recurrence, graft insufficiency or osteoarthritis.

Conclusion: Arthroscopic graft-retaining treatment combined with individual antibiotic therapy, eradication and good to excellent functional results can be achieved, which might encourage surgeons to try to retain the graft as much as possible.

Level Of Evidence: Level IV.
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http://dx.doi.org/10.1007/s00167-022-07059-3DOI Listing
July 2022

Two-dimensional fluoroscopy-guided robot-assisted percutaneous endoscopic transforaminal discectomy: a retrospective cohort study.

Am J Transl Res 2022 15;14(5):3121-3131. Epub 2022 May 15.

Department of Spine Surgery, Xi'an Jiaotong University College of Medicine, Honghui Hospital No. 76 Nanguo Road, Xi'an 710054, Shaanxi, China.

Percutaneous Endoscopic Transforaminal Discectomy (PETD) has been widely used for minimally invasive treatment of lumbar disc herniation (LDH), and percutaneous disc target puncture has a steep learning curve and high radiation exposure. Proper technology grafting can improve the surgical procedure and clinical outcomes. The changes brought by grafting surgical robots into PETD are worth investigating. A retrospective analysis was performed on the information of patients who received PETD in our hospital from March 2019 to July 2020. A total of 102 of patients who received 2D-guided robot-assisted PETD were included in Group A, and 102 of patients who received C-arm fluoroscopy-guided bare-handed PETD were included in Group B. The number of punctures, number of fluoroscopies, operation duration, intraoperative anxiety score, complications, and visual analogue scale (VAS) score and Oswestry disability index (ODI) before operation, on Day 1 after operation and at the last follow-up visit of the two groups were compared. All 204 patients received successful operations. Group A received 1.20±0.42 punctures, 10.49±2.16 fluoroscopies and 60.69±5.63 minutes of operation, significantly fewer than the 4.84±1.94 punctures, 17.41±3.23 fluoroscopies and 71.19±5.11 minutes of operation of Group B (all P<0.05), and Group A had significantly lower intraoperative anxiety scores and incidence of complications than Group B (both P<0.05). Both groups had comparable VAS and ODI scores on Day 1 after operation and at the last follow-up visit, which were both significantly higher than those before operation (P<0.05). 2D-guided robot-assisted PETD can enable precise planning of the puncture path, make it easier for operators to complete targeted punctures at pathogenic targets, reduce the number of punctures and fluoroscopies, shorten the operation duration to optimize the operation process, and reduce complications and alleviate intraoperative anxiety for better clinical results. Therefore it mayb be a better choice to assist PETD.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185024PMC
May 2022

Cross-linguistic patterns of speech prosodic differences in autism: A machine learning study.

PLoS One 2022 8;17(6):e0269637. Epub 2022 Jun 8.

Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, United States of America.

Differences in speech prosody are a widely observed feature of Autism Spectrum Disorder (ASD). However, it is unclear how prosodic differences in ASD manifest across different languages that demonstrate cross-linguistic variability in prosody. Using a supervised machine-learning analytic approach, we examined acoustic features relevant to rhythmic and intonational aspects of prosody derived from narrative samples elicited in English and Cantonese, two typologically and prosodically distinct languages. Our models revealed successful classification of ASD diagnosis using rhythm-relative features within and across both languages. Classification with intonation-relevant features was significant for English but not Cantonese. Results highlight differences in rhythm as a key prosodic feature impacted in ASD, and also demonstrate important variability in other prosodic properties that appear to be modulated by language-specific differences, such as intonation.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9176813PMC
June 2022

High-Frequency Repetitive Transcranial Magnetic Stimulation Regulates Astrocyte Activation by Modulating the Endocannabinoid System in Parkinson's Disease.

Mol Neurobiol 2022 Aug 7;59(8):5121-5134. Epub 2022 Jun 7.

Department of Rehabilitation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.

Reactive astrogliosis and the over-production of proinflammatory factors are key pathogenetic processes in Parkinson's disease (PD). Repetitive transcranial magnetic stimulation (rTMS), a promising noninvasive technique in treating PD, has been shown to alleviate neuroinflammation. However, high-frequency (HF) and low-frequency (LF) rTMS, which one produces better therapeutic and anti-inflammatory effects, and the underlying mechanism have yet to be determined. The efficacies of HF, LF, and sham rTMS on the survival of dopaminergic (DA) neurons, improvement of motor function, and downregulation of proinflammatory factors were compared in 6-hydroxydopamine (6-OHDA) rat model. Then we investigated the role of endocannabinoid (eCB) system in the inhibition of astrocyte activation between HF vs LF rTMS. The results showed that HF rTMS daily for 4 weeks produced stronger anti-inflammatory and neuroprotective effects. ECB receptor 2 (CB2R) but not receptor 1 (CB1R) expressions were substantially elevated in the GFAP-positive reactive astrocytes of the rat brains with 6-OHDA or LPS insults. Increased anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were also observed. Interestingly, the elevated CB2R, AEA and 2-AG, and the increased GFAP expression could be all significantly suppressed by HF rTMS, but not by LF rTMS. This effect was also confirmed in cell culture. Of note, selective agonism of CB2R was able to reverse HF rTMS-mediated activation of extracellular regulated kinase1/2 (Erk1/2) and suppression of GFAP expression, while selective antagonism of CB2R sustained these effects. This study indicates that the modulation of eCB/CB2R is a potential mechanism for the greater effectiveness of HF rTMS on the inhibition of astrogliosis.
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http://dx.doi.org/10.1007/s12035-022-02879-3DOI Listing
August 2022

30-norlanostane triterpenoids and steroid derivatives from the endophytic fungus Aspergillus nidulans.

Phytochemistry 2022 Sep 1;201:113257. Epub 2022 Jun 1.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. Electronic address:

Two undescribed 30-norlanostane triterpenoids, named nidulanoids A and B, one ergostane-type steroid with an unusual double bond between C-17 and C-20 designated (17E,22E,24R)-3β,5α-dihydroxyergosta-7,17,22-trien-6,16-dione, and one pregnane, (7Z,9Z,17Z)-,2α,3β-dihydroxypregna-7,9,17 (20)-trien-18-al, along with six known steroids were isolated from the extract of the fungus Aspergillus nidulans. Among them, nidulanosides A and B represents the first example of naturally occurred 30-norlanostane triterpenoids featuring a C9 side-chain moiety at C-17 and a hemiacetal system formed between C-3 and C-19, as an intermediate between lanostane and the regular steriods; the structure of (17E,22E,24R)-3β,5α-dihydroxyergosta-7,17,22-trien-6,16-dione possesses an untypical Δ double bond; meanwhile, (7Z,9Z,17Z)-,2α,3β-dihydroxypregna-7,9,17 (20)-trien-18-al represents the first example of C-21 steroid with an aldehyde group at C-13. Their structures and absolute stereochemistry were elucidated based on spectroscopic data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. (7Z,9Z,17Z)-,2α,3β-dihydroxypregna-7,9,17 (20)-trien-18-al showed moderate inhibitory activities against rat brain cancer (PC12) cell lines, with IC value of 7.34 μM. This study enriches the diversified structures of triterpenoids and steroids analogues from A. nidulans and indicated (7Z,9Z,17Z)-,2α,3β-dihydroxypregna-7,9,17(20)-trien-18-al to be a promising lead compound against PC12 cell lines.
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http://dx.doi.org/10.1016/j.phytochem.2022.113257DOI Listing
September 2022

The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study.

Front Cell Dev Biol 2022 11;10:917907. Epub 2022 May 11.

Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.

The COVID-19 pandemic caused by the severe acute coronavirus disease 2 (SARS-CoV-2) virus represents an ongoing threat to human health and well-being. Notably, many COVID-19 patients suffer from complications consistent with osteoporosis (OP) following disease resolution yet the mechanistic links between SARS-CoV-2 infection and OP remain to be clarified. The present study was thus developed to explore the potential basis for this link by employing transcriptomic analyses to identify signaling pathways and biomarkers associated with OP and SARS-CoV-2. Specifically, a previously published RNA-sequencing dataset (GSE152418) from Gene Expression Omnibus (GEO) was used to identify the differentially expressed genes (DEGs) in OP patients and individuals infected with SARS-CoV-2 as a means of exploring the underlying molecular mechanisms linking these two conditions. In total, 2,885 DEGs were identified by analyzing the COVID-19 patient dataset, with shared DEGs then being identified by comparison of these DEGs with those derived from an OP patient dataset. Hub genes were identified through a series of bioinformatics approaches and protein-protein interaction analyses. Predictive analyses of transcription factor/gene interactions, protein/drug interactions, and DEG/miRNA networks associated with these DEGs were also conducted. Together, these data highlight promising candidate drugs with the potential to treat both COVID-19 and OP.
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http://dx.doi.org/10.3389/fcell.2022.917907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130749PMC
May 2022

Highly sensitive metal ion sensing by graphene oxide functionalized micro-tapered long-period fiber grating.

Analyst 2022 Jun 27;147(13):3025-3034. Epub 2022 Jun 27.

State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Science, Xi'an, 710119, China.

An accurate as well as highly sensitive label-free chemical sensing platform for the detection of various metal ions was demonstrated. The chemical sensor was derived from the micro-tapered long-period fiber grating (MLPG) by depositing graphene oxide (GO) by chemical-bonding and optical-tweezer effects. The enhancement in refractive index (RI) sensitivity as well as reusability was obtained by evaluating the deposition thickness in the range of approximately 97.7 to 158.9 nm. Based on the analysis of adsorption principles, the enhanced RI sensitivity leads to a limit of detection as low as 3.2 ppb. The highest sensitivities for the cases studied using sodium and manganese ions in a wide concentration range of 1 ppb to 1 × 10 ppb are respectively 2.2 × 10 dB per ppb and 3.2 × 10 dB per ppb. Mixture samples were also studied to evaluate the properties of sensing the doped ions. This demonstration of GO modified MLPG is bound to find potential applications that require sensing of mixed samples and illustrates significant importance in developing cost-effective, label-free, reusable, and real-time chemical sensors.
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http://dx.doi.org/10.1039/d1an02263fDOI Listing
June 2022

Pre-transplant infusion of donor leukocytes treated with extracorporeal photochemotherapy induces immune hypo-responsiveness and long-term allograft survival in murine models.

Sci Rep 2022 05 4;12(1):7298. Epub 2022 May 4.

Department of Surgery, Comprehensive Transplant Center, Feinberg School of Medicine, Microsurgery Core, Northwestern University, Chicago, IL, USA.

Recipients of solid organ transplantation (SOT) rely on life-long immunosuppression (IS), which is associated with significant side effects. Extracorporeal photochemotherapy (ECP) is a safe, existing cellular therapy used to treat transplant rejection by modulating the recipient's own blood cells. We sought to induce donor-specific hypo-responsiveness of SOT recipients by infusing ECP-treated donor leukocytes prior to transplant. To this end, we utilized major histocompatibility complex mismatched rodent models of allogeneic cardiac, liver, and kidney transplantation to test this novel strategy. Leukocytes isolated from donor-matched spleens for ECP treatment (ECP-DL) were infused into transplant recipients seven days prior to SOT. Pre-transplant infusion of ECP-DL without additional IS was associated with prolonged graft survival in all models. This innovative approach promoted the production of tolerogenic dendritic cells and regulatory T-cells with subsequent inhibition of T-cell priming and differentiation, along with a significant reduction of donor-specific T-cells in the spleen and grafts of treated animals. This new application of donor-type ECP-treated leukocytes provides insight into the mechanisms behind ECP-induced immunoregulation and holds significant promise in the prevention of graft rejection and reduction in need of global immune suppressive therapy in patients following SOT.
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http://dx.doi.org/10.1038/s41598-022-11290-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068706PMC
May 2022

Modulating the Carbonization Degree of Carbon Dots for Multicolor Afterglow Emission.

ACS Appl Mater Interfaces 2022 May 4;14(19):22363-22371. Epub 2022 May 4.

Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China, Heilongjiang University, Harbin 150080, China.

Organic afterglow materials based on carbon dots (CDs) have aroused extensive attention for their potential applications in sensing, photoelectric devices, and anticounterfeiting. Effective methods to control the CD structure and modulate the energy levels are critical but still challenging. Here, we demonstrate a method to modulate the afterglow emission of [email protected] composites by controlling the carbonization degree of CDs with variable calcining temperatures. The [email protected] prepared with a hydrothermal bottom-up synthesis method shows a more polymerized structure of CDs with low carbonization degree, which emits long-lived thermally activated delayed fluorescence (TADF) with the lifetime of 252 ms. After calcination at 550 °C, [email protected] exhibits a larger conjugated π-domain structure with higher carbonization degree, thus inducing room-temperature phosphorescence (RTP) emission with a lifetime of 451 ms. The transformation of the carbonization degree of CD structures leads to changes in energy levels and Δ, which affect their afterglow luminescence behaviors. This work proposes a new concept to modulate the afterglow emission of [email protected] composites and forecasts potential applications of CD-based afterglow materials.
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http://dx.doi.org/10.1021/acsami.2c01804DOI Listing
May 2022

Crystal transformation and self-assembly theory of microbially induced calcium carbonate precipitation.

Appl Microbiol Biotechnol 2022 May 2;106(9-10):3555-3569. Epub 2022 May 2.

Key Laboratory of Building Safety and Energy Efficiency of Ministry of Education, Hunan University, Changsha, 410082, China.

Microbially induced calcium carbonate precipitation (MICP) is ubiquitous in the earth's lithosphere and brings the inspiration of bionic cementation technology. Over recent years, MICP has been proposed as a potential solution to address many environmental and engineering issues. However, the stability of cemented precipitations generated via MICP technology, especially the characteristics and change mechanism of crystal forms, is still unclear, which substantially hindered the understanding of biomineralization and prohibited the application and upscaling of MICP technology. Here, Sporosarcina pasteurii was selected as a model microbe to induce calcium carbonate mineralization in a series of standard nutrient solutions. The authors studied the process of precipitation from amorphous calcium carbonate to calcite crystal form and revealed the assembly behavior and mechanism of precipitations by FTIR, SEM, TEM and EDS. In the two crystal forms of induced calcium carbonate, the relative position and content of C, O, N, P and Ca elements were only slightly different. The molecular attachment and structural match of organic matrix made the crystals form change. Finally, a self-assembly theory was proposed to MICP, and it provided a solid theoretical basis for the technical specification of MICP technology in engineering application. KEY POINTS: • Organic matrix is intensively involved in MICP by forming functional groups. • Molecular attachment and structural match cause calcite crystal evolution. • A self-assembly theory is proposed for MICP.
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http://dx.doi.org/10.1007/s00253-022-11938-7DOI Listing
May 2022

Synthesis of Polycyclic 3,3'-Biindoles via AgOTf-Catalyzed Nucleophilic Addition and Cycloisomerization.

J Org Chem 2022 May 25;87(9):6418-6425. Epub 2022 Apr 25.

Shandong Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

A method for the rapid synthesis of polycyclic 3,3'-biindole derivatives has been developed through AgOTf-catalyzed nucleophilic addition and cycloisomerization processes. The cascade reaction employs readily accessible indoles and their -2-formylphenyl derivatives and provides functionalized polycyclic 3,3'-biindoles in moderate to good yields under mild conditions. This reaction is highly efficient and takes only several minutes (∼5 min). Notably, the method is also highlighted by a Selectfluor-mediated oxidation reaction that quickly generates the oxindole derivatives.
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http://dx.doi.org/10.1021/acs.joc.2c00275DOI Listing
May 2022

The Status of Selenium and Zinc in the Urine of Children From Endemic Areas of Kashin-Beck Disease Over Three Consecutive Years.

Front Nutr 2022 8;9:862639. Epub 2022 Apr 8.

Key Laboratory of Trace Elements and Endemic Diseases, Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

Selenium deficiency is one of the main risk factors for Kashin-Beck disease (KBD). This study aimed to detect the status of selenium and zinc in the urine of children from endemic areas of KBD over three consecutive years and to evaluate whether selenium and zinc levels in children in Shaanxi Province remain normal after stopping selenium supplementation. The samples of urine were collected in consecutive years (2017-2019) to detect selenium content by hydride generation atomic fluorescence spectrometry (HGAFS) and to detect zinc content by atomic absorption spectrophotometry (AAS). Generalized estimation equation (GEE) analysis was integrated to assess the comprehensive nutritional status and dietary structure of children. Data were processed in duplicate and analyzed by SPSS 18.0. This study included 30 X-ray-positive KBD cases and 123 healthy children aged 7-12 years. A total of 424 urine and 137 hair samples were collected over three consecutive years for selenium determination. The mean value of urinary selenium in all subjects was 6.86 μg/l (2017), 8.26 μg/l (2018), and 4.04 μg/l (2019), and the mean value of urinary zinc in all subjects was 0.36 mg/l (2017), 0.39 mg/l (2018), and 0.31 mg/l (2019) for the three consecutive years of 2017-2019. The mean values of urinary selenium were 6.56 and 6.94 μg/l (2017), 8.69 and 8.14 μg/l (2018), and 4.57 and 3.90 μg/l (2019) in the KBD-X and normal groups, respectively; and the mean value of urinary zinc were 0.38 and 0.35 mg/l (2017), 0.41 and 0.39 mg/l (2018), and 0.43 and 0.28 mg/l (2019) in the KBD-X and normal groups, respectively. The mean value of hair selenium in 137 subjects was 275.08 μg/kg and the mean values of hair selenium were 267.48 and 276.61 μg/kg in the KBD-X group and normal group, respectively. The level of selenium/zinc showed a trend of increasing first and then decreasing during the three consecutive years. The level of selenium in all subjects from the endemic areas was lower than normal, which reminds us to monitor the state of KBD constantly and adjust selenium salt supplementation in accordance with the changes in the KBD state.
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http://dx.doi.org/10.3389/fnut.2022.862639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033266PMC
April 2022

γ-secretase inhibitor disturbs the morphological development of differentiating neurons through affecting Notch/miR-342-5p.

Neurosci Lett 2022 05 29;778:136603. Epub 2022 Mar 29.

Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, 169 Chang Le Xi Road, Xi'an 710032, Shaanxi, China. Electronic address:

During neurodevelopment, differentiation of neural stem/progenitor cells (NSPCs) into neurons are regulated by many factors including Notch signaling pathway. Herein, we report the effect of a Notch signaling blocker, i.e. γ -secretase inhibitor (GSI), on this differentiating process, especially on the morphological development. NSPCs were cultured and induced to differentiate with or without GSI. The neurite outgrowth was impeded by GSI application and the expression of a Notch signaling downstream effector miR-342-5p increased with the downregulated expression of Notch effectors Hes1 and Hes5. Upregulated expression of miR-342-5p in differentiating NSPCs could shorten the neurite length of progeny neurons, which was similar to the effect of GSI. To avoid the possible influence from astrocytes into neurons, we directly applied cultured neurons, on which GSI could shorten the processes and RBP-J knockdown could also reduce the neurite length. Similarly, transfection of miR-342-5p mimics or inhibitors into PC12 cells led to shorter or longer processes of cells compared with control ones. Furthermore, in differentiating NSPCs, GSI-induced shorter neurites could be partially rescued by miR-342-5p inhibitors, and STAT3 was one of the possible targets of miR-342-5p during this differentiating process as indicated by results of Western Blot test, luciferase reporter assay and GFP reporter assay. To further demonstrate the role of STAT3, it was introduced into GSI-treated neurons and the GSI-affected neurites could also be partially rescued. In conclusion, GSI could influence the morphological development of neurons and the possible mechanism involved Notch/miR-342-5p and STAT3. These results would be informative for future therapeutic research.
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http://dx.doi.org/10.1016/j.neulet.2022.136603DOI Listing
May 2022

Tracking Object-State Representations During Real-Time Language Comprehension by Native and Non-native Speakers of English.

Authors:
Xin Kang Haoyan Ge

Front Psychol 2022 4;13:819243. Epub 2022 Mar 4.

School of Education and Languages, Hong Kong Metropolitan University, Hong Kong, Hong Kong SAR, China.

The present "visual world" eye-tracking study examined the time-course of how native and non-native speakers keep track of implied object-state representations during real-time language processing. Fifty-two native speakers of English and 46 non-native speakers with advanced English proficiency joined this study. They heard short stories describing a target object (e.g., ) either having undergone a substantial change-of-state (e.g., ) or a minimal change-of-state (e.g., ) while their eye movements toward competing object-states (e.g., a chopped onion vs. an intact onion) and two unrelated distractors were tracked. We found that both groups successfully directed their visual attention toward the end-state of the target object that was implied in the linguistic context. However, neither group showed anticipatory eye movements toward the implied object-state when hearing the critical verb (e.g., ""). Only native English speakers but not non-native speakers showed a bias in visual attention during the determiner ("") before the noun (e.g., ""). Our results suggested that although native and non-native speakers of English largely overlapped in their time-courses of keeping track of object-state representations during real-time language comprehension, non-native speakers showed a short delay in updating the implied object-state representations.
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http://dx.doi.org/10.3389/fpsyg.2022.819243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931953PMC
March 2022

Modified geosynthetic clay liners bentonite for barriers of Cr (VI) in contaminated soil.

Environ Technol 2022 Mar 17:1-13. Epub 2022 Mar 17.

College of Civil Engineering, Hunan University, Changsha, People's Republic of China.

Hydroxy-Fe-Al and cetyltrimethylammonium bromide (CTMAB) were chosen to modified Na-bentonite (Na-bent). The characteristics of Na-bent and modified bentonites were determined with scanning electron microscopy (SEM), energy disperse spectroscopy (EDS), X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR) and zeta potential. It was found that CTMAB mainly entered the interlayer and hydroxy-Fe-Al groups were mostly loaded on the external surface of the Na-bent, respectively. The efficiency to remove Cr (VI) of Na-bent, organic modified bentonite (O-bent), inorganic modified bentonite (I-bent) and composite modified bentonite (Co-bent) followed the order: Co-bent > I-bent > O-bent > Na-bent. Adsorption experiments were carried out by the batch contact method. The highest removal rate of Cr (VI) by Co-bent was found to be 96.2% at optimal pH = 4. The Cr (VI) uptake on Co-bent from 50 mg/L solution rapidly attained equilibrium within 10 min, and the pesudo-second-order kinetic model could provide satisfactory fitting of the kinetic data ( = 0.999) compared to the intraparticle diffusion model ( = 0.585). The adsorption data were applied to the Langmuir, Freundlich, Temkin isotherm model. The Langmuir was found to be the most suitable equation to fit the experimental data ( = 0.956) with a high Cr (VI) adsorption capacity of 27.472 mg/g, and values (0.012-0.035) also indicated the adsorption could be accepted. The present study confirmed that Co-bent would be one of candidates for Cr (VI) adsorbent.
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http://dx.doi.org/10.1080/09593330.2022.2050820DOI Listing
March 2022

Sterehirsutynes A - C: three new acetylenic aromatic metabolites from .

Nat Prod Res 2022 Mar 1:1-8. Epub 2022 Mar 1.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, People's Republic of China.

Three new acetylenic aromatic compounds, sterehirsutynes A-C (-), along with three known congeners, frustulosinol (), vibrayne (), and sterehirsutinol (), were isolated from the culture broth of . Their structures were determined by detailed analyses of NMR and high-resolution mass. Chiral column analysis showed that compounds and were racemic mixtures. These new compounds were evaluated for porcine pancreatic lipase (PPL) inhibitory activities, and compounds and (±) showed moderate inhibitory activity against PPL, with IC values of 23.2 ± 1.04 and 21.8 ± 2.15 μM, respectively.
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http://dx.doi.org/10.1080/14786419.2022.2047046DOI Listing
March 2022

Long-Term Exposure to Phenanthrene Induced Gene Expressions and Enzyme Activities of below the Safe Concentration.

Int J Environ Res Public Health 2022 02 14;19(4). Epub 2022 Feb 14.

Textile Pollution Controlling Engineering Center of Ministry of Environmental Protection, College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China.

Phenanthrene (PHE) is a typical compound biomagnified in the food chain which endangers human health and generally accumulates from marine life. It has been listed as one of the 16 priority PAHs evaluated in toxicology. In order to evaluate the changes of mRNA expression and EROD GST enzyme activity in carp exposed to lower than safe concentrations of PHE. Long-term exposure of carp to PHE at lower than safe concentrations for up to 25 days. The mRNA expression level and cytochrome P450 (CYP1A/EROD (7-Ethoxylesorufin O-deethylase)) and glutathione S-transferase (GST) activity were measured in carp liver and brain tissue. The results showed that PHE stress induced low-concentration induction and high-concentration inhibition of expression and EROD enzyme activity in the liver and brain of carp. In both two organs, GST enzyme activity was also induced. However, the expression of mRNA was first induced and then inhibited, after the 15th day. These results indicate that long-term exposure to PHE at lower than safe concentrations still poses a potential threat to carp's oxidase system and gene expression.
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http://dx.doi.org/10.3390/ijerph19042129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872569PMC
February 2022

All-optical TiCT modulator based on a sandwich structure.

Appl Opt 2022 Feb;61(4):925-930

All-optical modulators based on a - have recently garnered much attention due to their broadband light-matter interactions and ultrafast carrier dynamics. To investigate the modulation characteristics of pump intensity and pump light modulation frequency, we establish an all-optical modulator with a sandwich structure based on -/ (polyvinyl alcohol) film. The result shows that this modulator can achieve a high modulation depth of 12.55 dB and a modulation frequency of 50 kHz corresponding to a response time at the microsecond scale. The successful preparation of the modulator is attributed to the saturable absorption characteristics of the -. This modulator has great potential in all-optical communications and ultrafast optical signal processing.
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http://dx.doi.org/10.1364/AO.445975DOI Listing
February 2022

Human Amniotic Epithelial Cells and Their Derived Exosomes Protect Against Cisplatin-Induced Acute Kidney Injury Without Compromising Its Antitumor Activity in Mice.

Front Cell Dev Biol 2021 3;9:752053. Epub 2022 Feb 3.

Renal Division, Renal Pathology Center, Peking University First Hospital, Beijing, China.

Cisplatin is a widely used chemotherapeutic drug, whereas the clinical application is greatly limited by its nephrotoxic side effect. Currently, there has been no effective treatment to prevent cisplatin-induced acute kidney injury (cisplatin-AKI). Human amniotic epithelial cells (hAECs) and their derived exosomes (EXOs) have been proven to effectively protect against ischemia reperfusion-induced AKI, yet their roles in cisplatin-AKI are still unknown. C57BL/6J mice were given two doses of cisplatin at 20 or 15 mg/kg of body weight to induce AKI with or without mortality. hAECs or EXOs were injected via tail vein 1 day after cisplatin administration. Serum and kidney tissues were collected on the fourth day after 15 mg/kg cisplatin treatment to explore the nephro-protective effects of hAECs and EXOs on cisplatin-AKI. Lung cancer xenograft model was built by subcutaneous injection of A549 cells into BALB/c nude mice to evaluate the effect of hAECs or EXOs on cisplatin chemotherapy. Cisplatin nephrotoxicity was significantly attenuated by hAECs and EXOs as evidenced by reduced mortality rate and decreased serum creatinine (sCr) and reduced tubular injury score. hAECs or EXOs exerted the nephro-protective effects via suppression of TNF-α/MAPK and caspase signaling pathways. In the A549 lung cancer xenograft mouse model, administration of hAECs or EXOs did not promote tumor growth or compromise the therapeutic effects of cisplatin on tumors. This study is the first to demonstrate that hAECs and their derived exosomes have nephro-protective effects in cisplatin-AKI . Importantly, neither hAECs nor EXOs compromise the antitumor activity of cisplatin. These results potentially support the use of hAECs and their derived EXOs as nephro-protectors against cisplatin-induced nephrotoxicity clinically.
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http://dx.doi.org/10.3389/fcell.2021.752053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851426PMC
February 2022

Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis.

Comput Math Methods Med 2022 15;2022:7549894. Epub 2022 Jan 15.

Department of Cervical Spine Surgery, Hong Hui Hospital of Xi'an Jiaotong University, Xi'an, 710054 Shaanxi Province, China.

Purpose: Osteosarcoma (OS) is the most primary bone malignant tumor in adolescents. Although the treatment of OS has made great progress, patients' prognosis remains poor due to tumor invasion and metastasis.

Materials And Methods: We downloaded the expression profile GSE12865 from the Gene Expression Omnibus database. We screened differential expressed genes (DEGs) by making use of the R limma software package. Based on Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis, we performed the function and pathway enrichment analyses. Then, we constructed a Protein-Protein Interaction network and screened hub genes through the Search Tool for the Retrieval of Interacting Genes.

Result: By analyzing the gene expression profile GSE12865, we obtained 703 OS-related DEGs, which contained 166 genes upregulated and 537 genes downregulated. The DEGs were primarily abundant in ribosome, cell adhesion molecules, ubiquitin-ubiquitin ligase activity, and p53 signaling pathway. The hub genes of OS were KDR, CDH5, CD34, CDC42, RBX1, POLR2C, PPP2CA, and RPS2 through PPI network analysis. Finally, GSEA analysis showed that cell adhesion molecules, chemokine signal pathway, transendothelial migration, and focal adhesion were associated with OS.

Conclusion: In this study, through analyzing microarray technology and bioinformatics analysis, the hub genes and pathways about OS are identified, and the new molecular mechanism of OS is clarified.
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http://dx.doi.org/10.1155/2022/7549894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783756PMC
March 2022

Association between blood glucose levels and Glasgow Outcome Score in patients with traumatic brain injury: secondary analysis of a randomized trial.

Trials 2022 Jan 15;23(1):38. Epub 2022 Jan 15.

Department of Neurosurgery, The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, Lianyungang, Jiangsu, 222042, China.

Background: Blood glucose levels that are too high or too low after traumatic brain injury (TBI) negatively affect patient prognosis. This study aimed to demonstrate the relationship between blood glucose levels and the Glasgow Outcome Score (GOS) in TBI patients.

Methods: This study was based on a randomized, dual-center, open-label clinical trial. A total of 208 patients who participated in the randomized controlled trial were followed up for 5 years. Information on the disease, laboratory examination, insulin therapy, and surgery for patients with TBI was collected as candidate variables according to clinical importance. Additionally, data on 5-year and 6-month GOS were collected as primary and secondary outcomes, respectively. For multivariate analysis, a generalized additive model (GAM) was used to investigate relationships between blood glucose levels and GOS. The results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs). We further applied a two- piecewise linear regression model to examine the threshold effect of blood glucose level and GOS.

Results: A total of 182 patients were included in the final analysis. Multivariate GAM analysis revealed that a bell-shaped relationship existed between average blood glucose level and 5-year GOS score or 6-month GOS score. The inflection points of the average blood glucose level were 8.81 (95% CI: 7.43-9.48) mmol/L considering 5-year GOS as the outcome and were 8.88 (95% CI 7.43-9.74) mmol/L considering 6-month GOS score as the outcome. The same analysis revealed that there was also a bell relationship between average blood glucose levels and the favorable outcome group (GOS score ≥ 4) at 5 years or 6 months.

Conclusion: In a population of patients with traumatic brain injury, blood glucose levels were associated with the GOS. There was also a threshold effect between blood glucose levels and the GOS. A blood glucose level that is either too high or too low conveys a poor prognosis.

Trial Registration: ClinicalTrials.gov NCT02161055 . Registered on 11 June 2014.
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http://dx.doi.org/10.1186/s13063-022-06005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760745PMC
January 2022

The NAC-like transcription factor CsNAC7 positively regulates the caffeine biosynthesis-related gene yhNMT1 in Camellia sinensis.

Hortic Res 2022 Jan;9

College of Food Science, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong, 510642, China.

Caffeine is an important functional substance and is abundant in tea plant, but little is known about how its biosynthesis is regulated by transcription factors. In this study, the NAC-like transcription factor-encoding gene CsNAC7, which is involved in caffeine synthesis, was isolated from a Yinghong 9 cDNA library using a yeast one-hybrid assay; this gene comprises 1371 bp nucleotides and is predicted to encode 456 amino acids. The expression of CsNAC7 at the transcriptional level in tea shoots shared a similar pattern with that of the caffeine synthase gene yhNMT1 in the spring and summer, and its expressed protein was localized in the nucleus. Assays of gene activity showed that CsNAC7 has self-activation activity in yeast, that the active region is at the N-terminus, and that the transient expression of CsNAC7 could significantly promote the expression of yhNMT1 in tobacco leaves. In addition, overexpression or silencing of CsNAC7 significantly increased or decreased the expression of yhNMT1 and the accumulation of caffeine in transgenic tea calli, respectively. Our data suggest that the isolated transcription factor CsNAC7 positively regulates the caffeine synthase gene yhNMT1 and promotes caffeine accumulation in tea plant.
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http://dx.doi.org/10.1093/hr/uhab046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788374PMC
January 2022

Contributions of common genetic variants to specific languages and to when a language is learned.

Sci Rep 2022 01 12;12(1):580. Epub 2022 Jan 12.

Department of Obsterics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Research over the past two decades has identified a group of common genetic variants explaining a portion of variance in native language ability. The present study investigates whether the same group of genetic variants are associated with different languages and languages learned at different times in life. We recruited 940 young adults who spoke from childhood Chinese and English as their first (native) (L1) and second (L2) language, respectively, who were learners of a new, third (L3) language. For the variants examined, we found a general decrease of contribution of genes to language functions from native to foreign (L2 and L3) languages, with variance in foreign languages explained largely by non-genetic factors such as musical training and motivation. Furthermore, genetic variants that were found to contribute to traits specific to Chinese and English respectively exerted the strongest effects on L1 and L2. These results seem to speak against the hypothesis of a language- and time-universal genetic core of linguistic functions. Instead, they provide preliminary evidence that genetic contribution to language may depend at least partly on the intricate language-specific features. Future research including a larger sample size, more languages and more genetic variants is required to further explore these hypotheses.
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http://dx.doi.org/10.1038/s41598-021-04163-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8755716PMC
January 2022

Efficacy analysis of one-stage posterior-only surgical treatment for thoracic spinal tuberculosis in the T4-6 segments with minimum 5-year follow-up.

Sci Rep 2022 01 7;12(1):149. Epub 2022 Jan 7.

Department of Spine Surgery, Xi'an Jiaotong University College of Medicine, Honghui Hospital, Xi'an, 710054, Shaanxi, China.

In recent years, with the in-depth research on spinal tuberculosis, posterior surgery alone has been praised highly by more and more surgeons due to the better correction of kyphosis, better maintenance of spinal physiological curvature, smaller surgical trauma and fewer surgical complications. However, there is currently lack of relevant reports about the efficacy of posterior surgery alone in the treatment of tuberculosis in the T4-6 segments. This study aimed to evaluate the clinical study efficacy and feasibility of one-stage posterior-only surgical treatment for thoracic spinal tuberculosis in the T4-6 segments. 67 patients with tuberculosis in T4-6 segments who underwent one-stage posterior-only surgery were included in this study. The clinical efficacy was evaluated using statistical analysis based on the data about erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Oswestry Dability Index (ODI) score, Visual Analogue Scale (VAS) score and Cobb angle before surgery, after surgery and at the last follow-up. All patients completed fusion during the follow-up period of 6-9 months. ESR and CRP were returned to normal for all patients at 6 months follow-up. In the meanwhile, among the 27 patients combined with neurological impairment, neurological functions of 22 cases (81.48%) recovered completely at the last follow-up (P < 0.05). Cobb angle of the kyphosis was improved from preoperative 34.8 ± 10.9° to postoperative 9.6 ± 2.8°, maintaining at 11.3 ± 3.2° at the last follow-up, The ODI and VAS scores were improved by 77.10% and 81.70%, respectively. This 5-year follow-up study shows that better clinical efficacy can be achieved for tuberculosis in T4-6 segments using one-stage posterior-only approach by costotransverse debridement in combination with bone graft and internal fixation. The posterior surgical method cannot only effectively accomplish debridement, obtain satisfactory clinical results, but also well correct kyphotic deformity and maintain it.
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http://dx.doi.org/10.1038/s41598-021-04138-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742094PMC
January 2022

Efficient removal of 3,6-dichlorocarbazole with Fe-activated peroxymonosulfate: performance, intermediates and mechanism.

Environ Technol 2022 Feb 3:1-14. Epub 2022 Feb 3.

Textile Pollution Controlling Engineering Center of Ministry of Environmental Protection, College of Environmental Science and Engineering, Donghua University, Shanghai, People's Republic of China.

Nowadays, polyhalogenated carbazoles (PHCZs) are a major pollutant that has recently sparked widespread concern. In this work, peroxymonosulfate (PMS) was activated by zero valent iron (Fe) to remove 3,6-dichlorocarbazole (3,6-CCZ). First, the key parameters influencing 3,6-CCZ degradation (PMS dosage, Fe dosage, initial pH, temperature and co-existing ions) were determined. Under the determined optimum conditions, the removal rate of 3,6-CCZ reached 100% within 1.5 h. Sulfate radicals (SO·), hydroxyl radicals (OH·), and singlet oxygen (O) generated in the reaction were directly identified with 0.1 M 5,5-dimethyl-1-pyrrolidine N-oxide (DMPO) by in-situ electron paramagnetic resonance (EPR) and indirectly identified by radical quenching experiments. The main reactive oxygen species (ROS) were different from most reported hydroxyl radicals (OH·) and sulfate radicals (SO·). In this study, it was found that OH· and O play a major role. Then, fresh and reacted Fe were characterized by XRD, SEM, and XPS. Iron corrosion products such as FeO, FeO, and FeOOH were generated. Finally, 3,6-CCZ degradation intermediates were identified by GC-MS and its degradation pathway was speculated. The intermediate pathway confirmed the combined action of (OH·) and (O) in 3,6-CCZ removal. This study provides new insight into the activation mechanism of Fe-activated PMS and the removal mechanism of 3,6-CCZ. HighlightsFe is a long-lasting and efficient catalyst of PMS for the degradation of 3,6-CCZ.The key parameters influencing 3,6-CCZ degradation were determined.The degradation pathways of 3,6-CCZ were inferred.OH· and O were the main ROS in Fe-activated PMS system.
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http://dx.doi.org/10.1080/09593330.2021.2024888DOI Listing
February 2022

A prenatal case of lissencephaly with cerebellar hypoplasia: New mutation in RELN gene.

Clin Case Rep 2021 Dec 5;9(12):e04882. Epub 2021 Dec 5.

Department of Fetal Medicine CHU Saint-Pierre Brussels Belgium.

Reelinopathies cause a distinctive lissencephaly type associated with cerebellar hypoplasia. To help further management, we wanted to report here the first prenatal diagnosis due to a homozygous inherited reelinopathy.
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http://dx.doi.org/10.1002/ccr3.4882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645177PMC
December 2021

Phase I clinical trial of HC-1119 soft capsule in Chinese healthy adult male subjects: Pharmacokinetics and safety of single-dose proportionality and effects of food.

Prostate 2022 02 22;82(2):276-285. Epub 2021 Nov 22.

Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.

Background: Preclinical studies showed that HC-1119, a deuterated version of enzalutamide, could competitively inhibit androgen binding to androgen receptor by blocking the transmission of androgen receptor signaling pathway as enzalutamide, inducing apoptosis of prostate cancer cells and reducing the proliferation of prostate cancer cells. Animal pharmacokinetic studies also show that deuterization of enzalutamide as HC-1119 could retain the basic properties of mother drug, increases the stability of compounds to metabolic enzymes and the drug exposure in vivo, prolong the half-life and reduce the production of metabolites, which may lead to a better efficacy and safety of HC-1119 compared with enzalutamide.

Methods: To evaluate the pharmacokinetics and safety of HC-1119 and the effects of food on pharmacokinetics in healthy adult Chinese men after single-dose administration of HC-1119. A total of 47 Chinese healthy adult male subjects received HC-1119 soft capsule at a single oral dose of 40, 80, or 160 mg followed on fasting or 160 mg after high-fat meal respectively. HC-1119 prototype and its metabolites M1 and M2 in plasma were collected individually in a total 23 time points. Pharmacokinetics were determined by sensitive LC/MS/MS for dose-proportionality study.

Results: In subjects taking HC-1119 soft capsules on fasting, C of HC-1119 prototype increased dose-dependently. Either C and AUC of M1 or C of M2 showed statistically significant difference. Dose-proportionality evaluation showed linear pharmacokinetic characteristics in C of HC-1119 prototype, C and AUC of M2 in dose range of 40-160 mg. C of HC-1119 was significantly different between the two groups as 160 mg HC-1119 on fasting or after a high-fat diet respectively, while the other parameter were not. HC-1119 and its metabolites M1 and M2 showed a linear dynamic trend.

Conclusions: HC-1119 is expected to have lower clinical dose than the similar drug enzalutamide. The absorption of HC-1119 and the main pharmacokinetic parameters of HC-1119 and its metabolites M1 and M2 were not affected by high-fat diet. The clinical application of HC-1119 soft capsule in the later stage can be recommended for both fasting and postprandial. The safety and tolerance were good in this population.
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http://dx.doi.org/10.1002/pros.24271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298787PMC
February 2022

Modular composite building in urgent emergency engineering projects: A case study of accelerated design and construction of to COVID-19 pandemic.

Autom Constr 2021 Apr 22;124:103555. Epub 2021 Jan 22.

School of civil engineering, Central South University, Changsha 410075, Hunan, China.

Wuhan Leishenshan/Leishenshan ("Leishenshan" for short) hospital is a makeshift emergency hospital for treating patients diagnosed with the novel coronavirus-infected pneumonia (NCIP). Engineering construction uses modular composite building finished products to the greatest extent, which reduces the workload of field operations and saves a lot of time. The building information model (BIM) technology assists in design and construction work to meet rapid construction requirements. Besides, based on the unmanned aerial vehicles (UAVs) data analysis and application platform, digitization and intelligence in engineering construction are improved. Simultaneously, on-site construction and overall hoisting were carried out to achieve maximum efficiency. This article aims to take the construction of Leishenshan Hospital as an example to illustrate how to adopt BIM technology and other high-tech technology such as big data, artificial intelligence, drones, and 5G for the fast construction of the fabricated steel structure systems in emergency engineering projects.
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http://dx.doi.org/10.1016/j.autcon.2021.103555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589358PMC
April 2021
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