Xiling Shen

Xiling Shen

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Xiling Shen

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An imprecise path to precision medicine.

Authors:
Xiling Shen

Nat Med 2020 01;26(1):14

Department of Biomedical Engineering, Woo Center for Big Data and Precision Health, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1038/s41591-019-0718-6DOI Listing
January 2020

Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche.

Methods Mol Biol 2019 ;1975:3-35

Department of Biomedical Engineering, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1007/978-1-4939-9224-9_1DOI Listing
September 2019

Novel Three-Dimensional Cultures of Patient-Derived Cancer and Tumor Immune Cells.

Gastroenterology 2019 07 25;157(1):260-261. Epub 2019 May 25.

Department of Biomedical Engineering, Duke University, Durham, North Carolina.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194091
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http://dx.doi.org/10.1053/j.gastro.2019.05.036DOI Listing
July 2019

Mapping the microbial interactome: Statistical and experimental approaches for microbiome network inference.

Exp Biol Med (Maywood) 2019 04 16;244(6):445-458. Epub 2019 Mar 16.

Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1177/1535370219836771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547001PMC
April 2019

Computational motility models of neurogastroenterology and neuromodulation.

Brain Res 2018 08;1693(Pt B):174-179

Department of Biomedical Engineering, Duke University, Room 2167, CIEMAS, 101 Science Drive, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2018.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671680PMC
August 2018

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.

Micromachines (Basel) 2018 Aug 25;9(9). Epub 2018 Aug 25.

Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.

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http://www.mdpi.com/2072-666X/9/9/428
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http://dx.doi.org/10.3390/mi9090428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187697PMC
August 2018

Prometheus revisited.

J Clin Invest 2018 06 30;128(6):2192-2193. Epub 2018 Apr 30.

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http://dx.doi.org/10.1172/JCI120933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983318PMC
June 2018

TOWARD A MICROFLUIDIC IMPLEMENTATION OF A DIGITAL POTENTIOMETER.

2018 Des Med Devices Conf (2018) 2018 Apr;2018

Department of Biomedical Engineering Duke University, Durham, NC, United States.

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http://dx.doi.org/10.1115/DMD2018-6812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407897PMC
April 2018

A SIMPLE ASPECT RATIO DEPENDENT METHOD OF PATTERNING MICROWELLS FOR SELECTIVE CELL ATTACHMENT.

2018 Des Med Devices Conf (2018) 2018 Apr;2018

Department of Biomedical Engineering, Duke University Durham, NC, United States.

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http://dx.doi.org/10.1115/DMD2018-6811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408146PMC
April 2018

Electrical stimulation of gut motility guided by an in silico model.

J Neural Eng 2017 12;14(6):066010

Department of Biomedical Engineering, Duke University, Durham, NC, United States of America.

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http://dx.doi.org/10.1088/1741-2552/aa86c8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724779PMC
December 2017

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.

Nature 2017 09 6;549(7671):282-286. Epub 2017 Sep 6.

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature23676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066372PMC
September 2017

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.

Gastroenterology 2017 01 14;152(1):193-205.e10. Epub 2016 Sep 14.

Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163502
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http://dx.doi.org/10.1053/j.gastro.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164974PMC
January 2017

Asymmetric division: An antitumor player?

Mol Cell Oncol 2016 Jul 19;3(4):e1164279. Epub 2016 May 19.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA; Departments of Biomedical Engineering, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1080/23723556.2016.1164279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972103PMC
July 2016

NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.

Cancer Res 2016 06 11;76(11):3411-21. Epub 2016 Apr 11.

Department of Biomedical Engineering, Cornell University, Ithaca, New York. School of Electrical and Computer Engineering, Cornell University, Ithaca, New York. Department of Biomedical Engineering, Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891252PMC
June 2016

The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids.

J Vis Exp 2016 05 18(111). Epub 2016 May 18.

Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech;

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http://dx.doi.org/10.3791/54033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927701PMC
May 2016

A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.

Elife 2016 04 14;5. Epub 2016 Apr 14.

Department of Biological and Environmental Engineering, Cornell University, Ithaca, United States.

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http://dx.doi.org/10.7554/eLife.14620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859802PMC
April 2016

A real-time spike classification method based on dynamic time warping for extracellular enteric neural recording with large waveform variability.

J Neurosci Methods 2016 Mar 21;261:97-109. Epub 2015 Dec 21.

School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2015.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749467PMC
March 2016

A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.

Cell Stem Cell 2016 Feb;18(2):189-202

School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA; Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751059PMC
February 2016

Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles.

Biomaterials 2016 Jan 21;76:52-65. Epub 2015 Oct 21.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662903PMC
January 2016

miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.

Nat Commun 2015 Apr 15;6:6879. Epub 2015 Apr 15.

1] School of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA [2] Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA [3] Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1038/ncomms7879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399006PMC
April 2015

Epigenetics and cancer metabolism.

Cancer Lett 2015 Jan 11;356(2 Pt A):309-14. Epub 2013 Oct 11.

Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.09.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984372PMC
January 2015

Post-translational regulation enables robust p53 regulation.

BMC Syst Biol 2013 Aug 30;7:83. Epub 2013 Aug 30.

School of Electrical and Computer Engineering, 402 Phillips Hall, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1186/1752-0509-7-83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844394PMC
August 2013

Using an adaptive gene network model for self-organizing multicellular behavior.

Conf Proc IEEE Eng Med Biol Soc 2012 ;2012:5449-53

School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1109/EMBC.2012.6347227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310473PMC
July 2013

Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division.

J Biomed Sci Eng 2013 Feb;6(2):134-143

Department of Biomedical Engineering, Cornell University, Ithaca, USA ; School of Electrical and Computer Engineering, Cornell University, Ithaca, USA.

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http://dx.doi.org/10.4236/jbise.2013.62017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350780PMC
February 2013

Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.

J Clin Invest 2012 Sep 6;122(9):3184-96. Epub 2012 Aug 6.

Department of Medicine, Genetic Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI62110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428084PMC
September 2012

Adaptive models for gene networks.

PLoS One 2012 16;7(2):e31657. Epub 2012 Feb 16.

Electrical and Computer Engineering, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031657PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280989PMC
August 2012

Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation.

PLoS One 2011 28;6(7):e22852. Epub 2011 Jul 28.

Electrical and Computer Engineering, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022852PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145758PMC
December 2011

An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):18985-90. Epub 2010 Oct 18.

Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1014395107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973855PMC
November 2010

Architecture and inherent robustness of a bacterial cell-cycle control system.

Proc Natl Acad Sci U S A 2008 Aug 6;105(32):11340-5. Epub 2008 Aug 6.

Department of Electrical Engineering, 161 Packard Building, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0805258105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516238PMC
August 2008

Compensation for multimode fiber dispersion by adaptive optics.

Opt Lett 2005 Nov;30(22):2985-7

Department of Electrical Engineering, Stanford University, California 94305, USA.

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http://dx.doi.org/10.1364/ol.30.002985DOI Listing
November 2005