Publications by authors named "Xiaoyin Xu"

73Publications

Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration.

BMC Ophthalmol 2020 Mar 24;20(1):119. Epub 2020 Mar 24.

Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China.

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March 2020

Deep-Learning Detection of Cancer Metastases to the Brain on MRI.

J Magn Reson Imaging 2020 10 13;52(4):1227-1236. Epub 2020 Mar 13.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2020

Serum Metabolomics Reveals Personalized Metabolic Patterns for Macular Neovascular Disease Patient Stratification.

J Proteome Res 2020 02 9;19(2):699-707. Epub 2020 Jan 9.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital , Shanghai Engineering Center for Visual Science and Photomedicine , Shanghai 200040 , China.

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February 2020

A neural network approach to segment brain blood vessels in digital subtraction angiography.

Comput Methods Programs Biomed 2020 Mar 2;185:105159. Epub 2019 Nov 2.

Departments of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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March 2020

A retrospective study analyzing missed diagnosis of lung metastases at their early stages on computed tomography.

J Thorac Dis 2019 Aug;11(8):3360-3368

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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August 2019

A New Design in Iterative Image Deblurring for Improved Robustness and Performance.

Pattern Recognit 2019 Jun 17;90:134-146. Epub 2019 Jan 17.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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June 2019

Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor.

Acta Diabetol 2020 Jan 14;57(1):41-51. Epub 2019 May 14.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.

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January 2020

Insights into selenate removal mechanism of hydrogen-based membrane biofilm reactor for nitrate-polluted groundwater treatment based on anaerobic biofilm analysis.

Ecotoxicol Environ Saf 2019 Aug 15;178:123-129. Epub 2019 Apr 15.

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. Electronic address:

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August 2019

A neural network approach to analyze cross-sections of muscle fibers in pathological images.

Comput Biol Med 2019 01 12;104:97-104. Epub 2018 Nov 12.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

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January 2019

Clinical Validation of Automatable Gaussian Normalized CBV in Brain Tumor Analysis: Superior Reproducibility and Slightly Better Association with Survival than Current Standard Manual Normal Appearing White Matter Normalization.

Transl Oncol 2018 Dec 11;11(6):1398-1405. Epub 2018 Sep 11.

Dana-Farber Cancer Institute, Department of Imaging, Boston, MA, USA; Harvard Medical School, Department of Radiology, Boston, MA, USA; Brigham and Women's Hospital, Department of Radiology, Boston, MA, USA. Electronic address:

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December 2018

Effects of sulfate on simultaneous nitrate and selenate removal in a hydrogen-based membrane biofilm reactor for groundwater treatment: Performance and biofilm microbial ecology.

Chemosphere 2018 Nov 23;211:254-260. Epub 2018 Jul 23.

State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Institute of Pollution Control and Ecological Security, College of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, PR China. Electronic address:

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November 2018

Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells.

J Biochem 2018 Nov;164(5):381-391

Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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November 2018

Dynamic response of biofilm microbial ecology to para-chloronitrobenzene biodegradation in a hydrogen-based, denitrifying and sulfate-reducing membrane biofilm reactor.

Sci Total Environ 2018 Dec 27;643:842-849. Epub 2018 Jun 27.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China. Electronic address:

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December 2018

Direct solid-state evidence of H -induced partial U(VI) reduction concomitant with adsorption by extracellular polymeric substances (EPS).

Biotechnol Bioeng 2018 07 12;115(7):1685-1693. Epub 2018 Apr 12.

Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, Arizona.

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July 2018

BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression.

Genes Cells 2017 Dec 28;22(12):993-1003. Epub 2017 Nov 28.

Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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December 2017

Enhanced Hydrogen Production from Sawdust Decomposition Using Hybrid-Functional Ni-CaO-CaSiO Materials.

Environ Sci Technol 2017 Oct 14;51(19):11484-11492. Epub 2017 Sep 14.

School of Environment, Tsinghua University , Beijing 100084, China.

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October 2017

Application of Split-GFP Reassembly Assay to Study Myogenesis and Myofusion In Vitro.

Methods Mol Biol 2017 ;1668:127-134

Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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June 2018

LED Phototherapy with Gelatin Sponge Promotes Wound Healing in Mice.

Photochem Photobiol 2018 01 1;94(1):179-185. Epub 2017 Dec 1.

Beijing Advanced Innovation Center for Imaging Technology, Capital Normal University, Beijing, China.

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January 2018

Stomach frame-count-based attenuation correction of dynamic posterior view gastric emptying scintigraphy with continuous acquisition in children.

Pediatr Radiol 2017 Nov 6;47(12):1599-1607. Epub 2017 Jul 6.

Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

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November 2017

Joint volumetric extraction and enhancement of vasculature from low-SNR 3-D fluorescence microscopy images.

Pattern Recognit 2017 Mar 22;63:710-718. Epub 2016 Sep 22.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

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March 2017

Domain analysis of Ras-association domain family member 6 upon interaction with MDM2.

FEBS Lett 2017 01 17;591(2):260-272. Epub 2017 Jan 17.

Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.

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January 2017

Estimation of Split Renal Function With Tc-DMSA SPECT: Comparison Between 3D Volumetric Assessment and 2D Coronal Projection Imaging.

AJR Am J Roentgenol 2016 Dec 13;207(6):1324-1328. Epub 2016 Sep 13.

2 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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December 2016

Utilizing a one-dimensional multispecies model to simulate the nutrient reduction and biomass structure in two types of H2-based membrane-aeration biofilm reactors (H2-MBfR): model development and parametric analysis.

Environ Sci Pollut Res Int 2016 Feb 21;23(4):3436-49. Epub 2015 Oct 21.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China.

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February 2016

A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells.

Exp Cell Res 2015 Aug 24;336(2):171-81. Epub 2015 Jun 24.

Department of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

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August 2015

Automated high-content morphological analysis of muscle fiber histology.

Comput Biol Med 2015 Aug 23;63:28-35. Epub 2015 Apr 23.

Department of Radiology, Brigham and Women's Hospital, 20 Shattuck Street, Boston, MA 02115, USA. Electronic address:

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August 2015

A computational approach to detect and segment cytoplasm in muscle fiber images.

Microsc Res Tech 2015 Jun 20;78(6):508-18. Epub 2015 Apr 20.

Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China.

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June 2015

Bioreduction of vanadium (V) in groundwater by autohydrogentrophic bacteria: Mechanisms and microorganisms.

J Environ Sci (China) 2015 Apr 12;30:122-8. Epub 2015 Feb 12.

Swette Center for Environmental Biotechnology, Biodesign Institute at Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85287, USA.

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April 2015

A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks.

Med Image Anal 2015 Feb 28;20(1):208-23. Epub 2014 Nov 28.

Dept. Electrical and Computer Engineering, Tufts University, Medford, MA, USA.

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February 2015

Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.

Neuron 2014 Sep 21;83(5):1117-30. Epub 2014 Aug 21.

Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address:

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September 2014

An image processing approach to analyze morphological features of microscopic images of muscle fibers.

Comput Med Imaging Graph 2014 Dec 31;38(8):803-14. Epub 2014 Jul 31.

Department of Clinical Hematology, The Third Military Medical University, Chongqing, China. Electronic address:

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December 2014

Enhanced struvite recovery from wastewater using a novel cone-inserted fluidized bed reactor.

J Environ Sci (China) 2014 Apr;26(4):765-74

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

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April 2014

Options for tracking GFP-Labeled transplanted myoblasts using in vivo fluorescence imaging: implications for tracking stem cell fate.

BMC Biotechnol 2014 Jun 12;14:55. Epub 2014 Jun 12.

Department of Radiology, Functional and Molecular Imaging Center, Brigham & Women's Hospital, 75 Francis Street SR 153, Boston, MA 02115, USA.

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June 2014

Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability.

Stem Cells 2014 Sep;32(9):2492-501

College of Laboratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China; Department of Anesthesia Perioperative and Pain Medicine, Boston, Massachusetts, USA.

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September 2014

An image processing pipeline to detect and segment nuclei in muscle fiber microscopic images.

Microsc Res Tech 2014 Aug 29;77(8):547-59. Epub 2014 Apr 29.

Key laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China; Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China.

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August 2014

Effects of suspended titanium dioxide nanoparticles on cake layer formation in submerged membrane bioreactor.

Bioresour Technol 2014 12;152:101-6. Epub 2013 Nov 12.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

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August 2014

Clinical implications of CSN6 protein expression and correlation with mutant-type P53 protein in breast cancer.

Jpn J Clin Oncol 2013 Dec 8;43(12):1170-6. Epub 2013 Oct 8.

*Department of Surgical Oncology and Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.

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December 2013

Bioreduction of para-chloronitrobenzene in a hydrogen-based hollow-fiber membrane biofilm reactor: effects of nitrate and sulfate.

Biodegradation 2014 Apr 2;25(2):205-15. Epub 2013 Jul 2.

Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, College of Environmental Science and Engineering, Guilin University of Technology, 12# Jiangan Road, Guilin, 541004, Guangxi, China.

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April 2014

Simultaneous removal of selected oxidized contaminants in groundwater using a continuously stirred hydrogen-based membrane biofilm reactor.

J Environ Sci (China) 2013 Jan;25(1):96-104

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

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January 2013

Prevention of nodal metastases in breast cancer following the lymphatic migration of paclitaxel-loaded expansile nanoparticles.

Biomaterials 2013 Feb 8;34(7):1810-9. Epub 2012 Dec 8.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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February 2013

Computational techniques in zebrafish image processing and analysis.

J Neurosci Methods 2013 Feb 7;213(1):6-13. Epub 2012 Dec 7.

Key laboratory of Biomedical Engineering, of Ministry of Education Zhejiang University, Hangzhou, China.

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February 2013

CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6.

Cell Cycle 2012 Dec 27;11(24):4633-41. Epub 2012 Nov 27.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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December 2012

Is optimal timing of sentinel lymph node biopsy before neoadjuvant chemotherapy in patients with breast cancer? A literature review.

Surg Oncol 2012 Dec 21;21(4):252-6. Epub 2012 Jul 21.

Department of Surgical Oncology and Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.

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December 2012

Paclitaxel-loaded expansile nanoparticles in a multimodal treatment model of malignant mesothelioma.

Ann Thorac Surg 2011 Dec 1;92(6):2007-13; discussion 2013-4. Epub 2011 Oct 1.

Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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December 2011

Automated analysis of zebrafish images for phenotypic changes in drug discovery.

J Neurosci Methods 2011 Sep 8;200(2):229-36. Epub 2011 Jul 8.

Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, China.

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September 2011

C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin.

Clin Cancer Res 2011 Mar 1;17(5):1065-74. Epub 2010 Dec 1.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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March 2011

A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images.

J Biomol Screen 2010 Oct;15(9):1152-9

Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, China.

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October 2010

In vivo manifestation of Notch related phenotypes in zebrafish treated with Alzheimer's amyloid reducing gamma-secretase inhibitors.

J Neurochem 2010 Jun 12;113(5):1200-9. Epub 2010 Mar 12.

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2010

Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.

BMC Biotechnol 2010 Mar 22;10:24. Epub 2010 Mar 22.

Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA, USA.

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March 2010

In vivo fluorescence imaging of muscle cell regeneration by transplanted EGFP-labeled myoblasts.

Mol Ther 2010 Apr 2;18(4):835-42. Epub 2010 Feb 2.

Functional and Molecular Imaging Center, Optical Imaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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April 2010

Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.

J Am Chem Soc 2009 Oct;131(42):15257-61

Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown, Massachusetts 02129, USA.

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October 2009

Tracking dynamics of muscle engraftment in small animals by in vivo fluorescent imaging.

J Vis Exp 2009 Sep 21(31). Epub 2009 Sep 21.

Department of Anesthesia, Brigham and Woman's Hospital, USA.

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September 2009

Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta protein.

Cancer Cell Int 2009 Jun 1;9:15. Epub 2009 Jun 1.

Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, The MethodistHospital, Weill Cornell Medical College, Houston, Texas 77030, USA.

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June 2009

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model.

Exp Neurol 2009 Sep 13;219(1):146-55. Epub 2009 May 13.

Pain Research Center, Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, MA 02115, USA.

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September 2009

Robust 3D reconstruction and identification of dendritic spines from optical microscopy imaging.

Med Image Anal 2009 Feb 24;13(1):167-79. Epub 2008 Jul 24.

Department of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA.

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February 2009

A quantitative study of factors affecting in vivo bioluminescence imaging.

Luminescence 2008 Sep-Oct;23(5):292-5

Department of Radiology, The Methodist Hospital, Weill Cornell University, Houston, TX 77030, USA.

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November 2008

Using nonlinear diffusion and mean shift to detect and connect cross-sections of axons in 3D optical microscopy images.

Med Image Anal 2008 Dec 25;12(6):666-75. Epub 2008 Mar 25.

Department of Mathematics, The University of Hong Kong, Hong Kong, China.

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December 2008

Repulsive force based snake model to segment and track neuronal axons in 3D microscopy image stacks.

Neuroimage 2006 Oct 24;32(4):1608-20. Epub 2006 Jul 24.

Center for Bioinformatics, Harvard Center for Neurodegeneration and Repair, and Department of Radiology, Brigham and Women's Hospital, Boston, MA 02114, USA.

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October 2006

Adaptive two-pass rank order filter to remove impulse noise in highly corrupted images.

IEEE Trans Image Process 2004 Feb;13(2):238-47

Center for Subsurface Sensing and Imaging Systems, Department of Electrical and Computer Engineering, Northeastern University, Boston, MA 02115, USA.

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February 2004

[Thermal tolerance, diel variation of body temperature, and thermal dependence of locomotor performance of hatchling soft-shelled turtles, Trionyx sinensis].

Ying Yong Sheng Tai Xue Bao 2002 Sep;13(9):1161-5

Department of Ocean and Fisheries, School of Life Sciences, Ningbo University, Ningbo 315211.

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September 2002