Publications by authors named "Xiaoyang Liu"

206 Publications

Association between vertebral rotatory subluxation and the apical vertebra in degenerative lumbar scoliosis.

World Neurosurg 2021 Jul 27. Epub 2021 Jul 27.

Department of Spine Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Department of Spine Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Electronic address:

Objective: To identify the apical vertebra is relate to the occurrence of vertebral rotatory subluxation(VRS) in degenerative lumbar scoliosis.

Methods: 86 patients with degenerative lumbar scoliosis included in this retrospective study were divided into two groups: with VRS and without VRS. Coronal and sagittal parameters were measured on whole-spine anteroposterior and lateral X-ray.The impact of VRS on the spine and pelvis parameters was statistically analyzed, and the correlation between the occurrence of VRS and the apical vertebra was analyzed by using logistic regression.

Results: VRS was present in 49 degenerative lumbar scoliosis patients and absent in 37 patients. Compared with the patients without VRS, the patients with VRS had a smaller lumbar lordosis and thoracic kyphosis (P<0.05) and a larger apical vertebra translation, apical vertebra tilt angle, cobb angle and PI-LL (P<0.05). Logistic regression analysis showed that apical vertebra translation and apical vertebra tilt angle were risk factors for the occurrence of VRS. The receiver operating characteristic curve analysis showed that apical vertebra translation greater than 23.2 mm and apical vertebra tilt angle greater than 11.8° were related to a higher probability of VRS in degenerative lumbar scoliosis patients.

Conclusions: VRS is an important characteristic to consider in degenerative lumbar scoliosis that can affect the coronal and sagittal alignment. The apical vertebra is correlated with the occurrence of VRS; an apical vertebra translation greater than 23.2 mm and apical vertebra tilt angle greater than 11.8° are highly correlate with VRS occurrence.
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http://dx.doi.org/10.1016/j.wneu.2021.07.101DOI Listing
July 2021

Correction for: STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8.

Aging (Albany NY) 2021 07 15;13(13):17953-17954. Epub 2021 Jul 15.

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, PR China.

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http://dx.doi.org/10.18632/aging.203346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312425PMC
July 2021

Understanding Gas Solubility of Pure Component and Binary Mixtures within Multivalent Ionic Liquids from Molecular Simulations.

J Phys Chem B 2021 Jul 14;125(29):8165-8174. Epub 2021 Jul 14.

Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama 35487, United States.

Understanding the molecular-level solubility of CO and its mixtures is essential to the progress of gas-treating technologies. Herein, we use grand canonical Monte Carlo simulations to study the single-component gas absorption of SO, N, CH, and H and binary mixtures of CO/SO, CO/N, CO/CH, and CO/H of varying mole fractions within multivalent ionic liquids (ILs). Our results highlight the importance of the free volume effect and the anion effect when interpreting the absorption behavior of these mixtures, similar to the behavior of CO found in our previous study ( 20618-20633). The deviation of gas solubility between the pure component absorption the binary absorption, as well as the solubility selectivity, highlights the importance of the relative affinity of gas species within a mixture to the different anions. The absorption selectivity within a specific IL system can be predicted based on the relative gas affinity to the anion.
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http://dx.doi.org/10.1021/acs.jpcb.1c04212DOI Listing
July 2021

Repurposing Erythrocytes as a "Photoactivatable Bomb": A General Strategy for Site-Specific Drug Release in Blood Vessels.

Small 2021 Jul 14:e2100753. Epub 2021 Jul 14.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.

Tumor vasculature has long been considered as an extremely valuable therapeutic target for cancer therapy, but how to realize controlled and site-specific drug release in tumor blood vessels remains a huge challenge. Despite the widespread use of nanomaterials in constructing drug delivery systems, they are suboptimal in principle for meeting this demand due to their easy blood cell adsorption/internalization and short lifetime in the systemic circulation. Here, natural red blood cells (RBCs) are repurposed as a remote-controllable drug vehicle, which retains RBC's morphology and vessel-specific biodistribution pattern, by installing photoactivatable molecular triggers on the RBC membrane via covalent conjugation with a finely tuned modification density. The molecular triggers can burst the RBC vehicle under short and mild laser irradiation, leading to a complete and site-specific release of its payloads. This cell-based vehicle is generalized by loading different therapeutic agents including macromolecular thrombin, a blood clotting-inducing enzyme, and a small-molecule hypoxia-activatable chemodrug, tirapazamine. In vivo results demonstrate that the repurposed "anticancer RBCs" exhibit long-term stability in systemic circulation but, when tumors receive laser irradiation, precisely releases their cargoes in tumor vessels for thrombosis-induced starvation therapy and local deoxygenation-enhanced chemotherapy. This study proposes a general strategy for blood vessel-specific drug delivery.
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http://dx.doi.org/10.1002/smll.202100753DOI Listing
July 2021

Fabrication and applications of bioactive chitosan-based organic-inorganic hybrid materials: A review.

Carbohydr Polym 2021 Sep 8;267:118179. Epub 2021 May 8.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

Organic-inorganic hybrid materials like bone, shells, and teeth can be found in nature, which are usually composed of biomacromolecules and nanoscale inorganic ingredients. Synergy of organic-inorganic components in hybrid materials render them outstanding and versatile performance. Chitosan is commonly used organic materials in bionic hybrid materials since its bioactive properties and could be controllable tailored by various means to meet complex conditions in different applications. Among these fabrication means, hybridization was favored for its convenience and efficiency. This review discusses three kinds of chitosan-based hybrid materials: hybridized with hydroxyapatite, calcium carbonate, and clay respectively, which are the representative of phosphate, carbonate, and hydrous aluminosilicates. Here, we reported the latest developments of the preparation methods, composition, structure and applications of these bioactive hybrid materials, especially in the biomedical field. Despite the great progress was made in bioactive organic-inorganic hybrid materials based on chitosan, some challenges and specific directions are still proposed for future development in this review.
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http://dx.doi.org/10.1016/j.carbpol.2021.118179DOI Listing
September 2021

Malicious traffic detection combined deep neural network with hierarchical attention mechanism.

Sci Rep 2021 Jun 11;11(1):12363. Epub 2021 Jun 11.

School of Computer Science and Engineering, Chongqing University of Technology, Chongqing, 400054, China.

Given the gradual intensification of the current network security situation, malicious attack traffic is flooding the entire network environment, and the current malicious traffic detection model is insufficient in detection efficiency and detection performance. This paper proposes a data processing method that divides the flow data into data flow segments so that the model can improve the throughput per unit time to meet its detection efficiency. For this kind of data, a malicious traffic detection model with a hierarchical attention mechanism is also proposed and named HAGRU (Hierarchical Attention Gated Recurrent Unit). By fusing the feature information of the three hierarchies, the detection ability of the model is improved. An attention mechanism is introduced to focus on malicious flows in the data flow segment, which can reasonably utilize limited computing resources. Finally, compare the proposed model with the current state of the method on the datasets. The experimental results show that: the novel model performs well in different evaluation indicators (detection rate, false-positive rate, F-score), and it can improve the performance of category recognition with fewer samples when the data is unbalanced. At the same time, the training of the novel model on larger datasets will enhance the generalization ability and reduce the false alarm rate. The proposed model not only improves the performance of malicious traffic detection but also provides a new research method for improving the efficiency of model detection.
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http://dx.doi.org/10.1038/s41598-021-91805-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196150PMC
June 2021

Exogenous N-acyl-homoserine lactones accelerate resuscitation of starved anaerobic granular sludge after long-term stagnation.

Bioresour Technol 2021 Oct 3;337:125362. Epub 2021 Jun 3.

Tianjin Key Laboratory of Clean Energy and Pollution Control, School of Energy and Environmental Engineering, Hebei University of Technology, Tianjin 300401, PR China. Electronic address:

So as to accelerate the resuscitation of starved anaerobic granular sludge after long-term stagnation, an innovative method was tried derived from the regulation of N-acyl-homoserine lactones (AHLs)-mediated quorum sensing (QS). The mixture of four AHLs was added to the starved anaerobic granular sludge system in this research. The results confirmed that the exogenous AHLs shortened the recovery time of the granular sludge, and improved the treatment performance and methanogenic capacity of the recovered anaerobic sludge to the level before stagnation. At the same time, exogenous AHLs enhanced the synthesis of extracellular polymeric substances (EPS) during the resuscitation period of starved anaerobic granular sludge. The outcomes of microbial composition detection showed that the change of bacterial and methanogenic bacteria communities towards accelerated performance recovery was significantly correlated with exogenous AHLs. This exploration provided a new technical idea for speeding up the recovery of starved anaerobic granular sludge.
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http://dx.doi.org/10.1016/j.biortech.2021.125362DOI Listing
October 2021

Formation of three-dimensional bicontinuous structures via molten salt dealloying studied in real-time by in situ synchrotron X-ray nano-tomography.

Nat Commun 2021 Jun 9;12(1):3441. Epub 2021 Jun 9.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, NY, USA.

Three-dimensional bicontinuous porous materials formed by dealloying contribute significantly to various applications including catalysis, sensor development and energy storage. This work studies a method of molten salt dealloying via real-time in situ synchrotron three-dimensional X-ray nano-tomography. Quantification of morphological parameters determined that long-range diffusion is the rate-determining step for the dealloying process. The subsequent coarsening rate was primarily surface diffusion controlled, with Rayleigh instability leading to ligament pinch-off and creating isolated bubbles in ligaments, while bulk diffusion leads to a slight densification. Chemical environments characterized by X-ray absorption near edge structure spectroscopic imaging show that molten salt dealloying prevents surface oxidation of the metal. In this work, gaining a fundamental mechanistic understanding of the molten salt dealloying process in forming porous structures provides a nontoxic, tunable dealloying technique and has important implications for molten salt corrosion processes, which is one of the major challenges in molten salt reactors and concentrated solar power plants.
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http://dx.doi.org/10.1038/s41467-021-23598-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190292PMC
June 2021

Multistability and associative memory of neural networks with Morita-like activation functions.

Neural Netw 2021 Apr 30;142:162-170. Epub 2021 Apr 30.

Centre for Artificial Intelligence, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address:

This paper presents the multistability analysis and associative memory of neural networks (NNs) with Morita-like activation functions. In order to seek larger memory capacity, this paper proposes Morita-like activation functions. In a weakened condition, this paper shows that the NNs with n-neurons have (2m+1) equilibrium points (Eps) and (m+1) of them are locally exponentially stable, where the parameter m depends on the Morita-like activation functions, called Morita parameter. Also the attraction basins are estimated based on the state space partition. Moreover, this paper applies these NNs into associative memories (AMs). Compared with the previous related works, the number of Eps and AM's memory capacity are extensively increased. The simulation results are illustrated and some reliable associative memories examples are shown at the end of this paper.
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http://dx.doi.org/10.1016/j.neunet.2021.04.035DOI Listing
April 2021

The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.

J Cell Mol Med 2021 Jun 3;25(12):5671-5680. Epub 2021 May 3.

Department of spine surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Iron overload is common in elderly people which is implicated in the disease progression of osteoarthritis (OA), however, how iron homeostasis is regulated during the onset and progression of OA and how it contributes to the pathological transition of articular chondrocytes remain unknown. In the present study, we developed an in vitro approach to investigate the roles of iron homeostasis and iron overload mediated oxidative stress in chondrocytes under an inflammatory environment. We found that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis via upregulating iron influx transporter TfR1 and downregulating iron efflux transporter FPN, thus leading to chondrocytes iron overload. Iron overload would promote the expression of chondrocytes catabolic markers, MMP3 and MMP13 expression. In addition, we found that oxidative stress and mitochondrial dysfunction played important roles in iron overload-induced cartilage degeneration, reducing iron concentration using iron chelator or antioxidant drugs could inhibit iron overload-induced OA-related catabolic markers and mitochondrial dysfunction. Our results suggest that pro-inflammatory cytokines could disrupt chondrocytes iron homeostasis and promote iron influx, iron overload-induced oxidative stress and mitochondrial dysfunction play important roles in iron overload-induced cartilage degeneration.
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http://dx.doi.org/10.1111/jcmm.16581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184674PMC
June 2021

N-Enriched Porous Carbon/SiO Composites Derived from Biomass Rice Husks for Boosting Li-Ion Storage: Insight into the Effect of N-Doping.

Chemistry 2021 Jul 14;27(41):10749-10757. Epub 2021 Jun 14.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.

A N-enriched porous carbon/SiO (SiO /NC) composite from rice husks was prepared by ball milling and tested as a stable anode for lithium ion batteries (LIBs), in which the homogeneous dispersion of SiO nanoparticles and carbon matrix, and high level of N-doping can be realized simultaneously. The influence of N-doping on a series of SiO /NCs was systematically studied; this proved that the porosity, N-doping content, and electronic conductivity of SiO /NC can be controlled by adjusting common nitrogen sources (urea and melamine) and doping routes, including dry and wet milling, to reach a desirable balance of high capacity, long-term cyclability, and rate property. The optimized SiO /NC composite delivers a stably reversible capacity of 581 mA h g at the high current load of 1.0 A g at the 1000th cycle. The novel Li-storage mechanism of active silica in a composite was first proposed after observation of the N-doping effect that the redox reaction between SiO and Li is accelerated to transform into an alloying reaction of generated Si and Li , thus enhancing the reversible capacity. Moreover, kinetics analysis confirms that there is a combined Li-storage mechanism of battery-capacitive pattern in composite that contributes to fast charge transfer and ion diffusion during cycle.
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http://dx.doi.org/10.1002/chem.202100727DOI Listing
July 2021

Intracellular Synthesis of Hybrid Gallium-68 Nanoparticle Enhances MicroPET Tumor Imaging.

Anal Chem 2021 04 13;93(16):6329-6334. Epub 2021 Apr 13.

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.

Positron-emission tomography (PET) imaging enables cancer diagnosis at an early stage and to determine its pathological degree. However, tumor uptake efficiency of traditional PET radiotracers is usually low. Herein, we rationally designed a precursor CBT-NODA, the cold analogue CBT-NODA-Ga, and its corresponding radiotracer CBT-NODA-Ga. Using these three compounds, we verified that coinjection of CBT-NODA-Ga with CBT-NODA or CBT-NODA-Ga could lead to the synthesis of hybrid gallium-68 nanoparticles in furin-overexpressing cancer cells and enhance microPET tumor imaging in mice. experiments showed that coinjection of CBT-NODA-Ga with CBT-NODA-Ga had the most prolonged retention of the radiotracer in blood, the highest radioactivity in tumor regions, and the most enhanced microPET tumor imaging in mice. We anticipate that, by combining the coinjection strategy with our CBT-Cys click condensation reaction, more radiotracers are developed for microPET imaging of more tumors in clinical settings in the future.
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http://dx.doi.org/10.1021/acs.analchem.1c00747DOI Listing
April 2021

Effects of Chiral Molecule Modification on Surface Biosorption Behavior.

Langmuir 2021 04 8;37(15):4441-4448. Epub 2021 Apr 8.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, National Demonstration Center for Experimental, Biomedical Engineering Education, Southeast University, Nanjing 210096, China.

Antifouling materials have many important applications in biomedical devices and marine coating. Oligo(ethylene glycol) (OEG) or poly(ethylene glycol) (PEG) exhibit promising antifouling properties and are widely used in biomedical engineering. Chiral selection is an important phenomenon in biological processes. Because of the influence of steric hindrance, the modification of chiral molecules with different chirality at interfaces will affect the intermolecular interaction at the interfaces and lead to different structures of interfacial molecules. The difference of surface structures such as surface hydration structure would impact the adsorption of biomolecules on the surface, thus causing different varieties of cell adhesion and cell growth. In this study, the influence on surface hydration and surface cell adhesion of OEG self-assembled monolayers (SAMs) modified with cysteine showing different chirality are explored. The water structure at the interfaces of OEG/water in different conditions was probed with sum frequency generation vibrational spectroscopy (SFG-VS). The results show that the interfacial water structure can change significantly with either d-cysteine or l-cysteine modification on OEG. Water molecules are more ordered at the OEG/water interface under the d-cysteine modification on OEG SAMs, which improves the protein adsorption resistance of the surface. In contrast, l-cysteine modification would make the water less ordered at the OEG/protein solution interface and enhance the protein adsorption. Additionally, optical micrographs indicate that l-cysteine can significantly promote the OEG SAMs cell adhesion and growth, while d-cysteine exhibits an inhibitory effect, which is consistent with the results of SFG-VS experiments.
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http://dx.doi.org/10.1021/acs.langmuir.0c03551DOI Listing
April 2021

Screening Ionic Liquids Based on Ionic Volume and Electrostatic Potential Analyses.

J Phys Chem B 2021 04 6;125(14):3653-3664. Epub 2021 Apr 6.

Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama 35487, United States.

Ionic liquids (ILs) are known to have tunable solvation properties, based on the pairing of different anions and cations, but the compositional landscape is vast and challenging to navigate efficiently. Some computational screening protocols are available, but they can be either time-consuming or difficult to implement. Herein, we perform a detailed investigation of the fundamental role of electrostatic interactions in these systems. We effectively develop a bridge between the previous volume-based approach with a quantum structure-property relationship approach to create fast, simple screening guidelines. We propose a new parameter that is applicable to both monovalent and multivalent ions, the ionic polarity index (IPI), which is defined as the ratio of the average electrostatic surface potential () of the ion to the net charge of the ion (). The IPI correlation has been tested on a diverse data set of 121 ions, and reliable predictions can be obtained within a homologous series of IL compounds.
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http://dx.doi.org/10.1021/acs.jpcb.0c10259DOI Listing
April 2021

Solubility Behavior of CO in Ionic Liquids Based on Ionic Polarity Index Analyses.

J Phys Chem B 2021 Apr 2;125(14):3665-3676. Epub 2021 Apr 2.

Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, Alabama 35487, United States.

Ionic liquids (ILs) can serve as effective CO solvents with an appropriate selection of different anions and cations. However, due to the large library of potential IL compositions, rapid screening methods are needed for characterizing and ranking the expected properties. We have recently proposed the ionic polarity index (IPI) parameter, effectively connecting volume-based approaches and electrostatic potential analyses and providing a single metric that can potentially be used to rapidly screen for desirable IL properties. In this work, the corresponding anion and cation IPIs are used to generate correlations with respect to the CO volumetric solubility in ILs. The relationships are generally applicable to groups of ILs within a homologous ion series, and this can be particularly valuable for prescreening different ion pairings for maximizing gas solvation performance.
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http://dx.doi.org/10.1021/acs.jpcb.1c01508DOI Listing
April 2021

A diagnostic model for differentiating tuberculous spondylitis from pyogenic spondylitis on computed tomography images.

Eur Radiol 2021 Mar 25. Epub 2021 Mar 25.

Department of Spine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 in Jingshi Road, Jinan City, China.

Objectives: To develop and evaluate a logistics regression diagnostic model based on computer tomography (CT) features to differentiate tuberculous spondylitis (TS) from pyogenic spondylitis (PS).

Methods: Demographic and clinical features were collected from the Electronic Medical Record System. Data of bony changes seen on CT images were compared between the PS (n = 61) and TS (n = 51) groups using the chi-squared test or t test. Based on features that were identified to be significant, a diagnostic model was developed from a derivation set (two thirds) and evaluated in a validation set (one third). The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated.

Results: The width of bone formation around the vertebra and sequestrum was greater in the TS group. There were significant differences between the two groups in the horizontal and longitudinal location of erosion and the morphology of axial bone destruction and sagittal residual vertebra. Kyphotic deformity and overlapping vertebrae were more common in the TS group. A diagnostic model that included eight predictors was developed and simplified to include the following six predictors: width of the bone formation surrounding the vertebra, longitudinal location, axial-specific erosive morphology, specific morphology of the residual vertebra, kyphotic deformity, and overlapping vertebrae. The simplified model showed good sensitivity, specificity, and total accuracy (85.59%, 87.80%, and 86.50%, respectively); the AUC was 0.95, indicating good clinical predictive ability.

Conclusions: A diagnostic model based on bone destruction and formation seen on CT images can facilitate clinical differentiation of TS from PS.

Key Points: • We have developed and validated a simple diagnostic model based on bone destruction and formation observed on CT images that can differentiate tuberculous spondylitis from pyogenic spondylitis. • The model includes six predictors: width of the bone formation surrounding the vertebra, longitudinal location, axial-specific erosive morphology, specific morphology of the residual vertebra, kyphotic deformity, and overlapping vertebrae. • The simplified model has good sensitivity, specificity, and total accuracy with a high AUC, indicating excellent predictive ability.
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http://dx.doi.org/10.1007/s00330-021-07812-1DOI Listing
March 2021

Semiconducting and Metallic [5,5] Fullertube Nanowires: Characterization of Pristine D(1)-C and D(1)-C.

J Am Chem Soc 2021 Mar 18;143(12):4593-4599. Epub 2021 Mar 18.

Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.

Although fullerenes were discovered nearly 35 years ago, scientists still struggle to isolate "single molecule" tubular fullerenes larger than C. In similar fashion, there is a paucity of reports for pristine single-walled carbon nanotubes (SWNTs). In spite of Herculean efforts, the isolation and properties of pristine members of these carbonaceous classes remain largely unfulfilled. For example, the low abundance of spherical and tubular higher fullerenes in electric-arc extracts (<0.01-0.5%) and multiplicity of structural isomers remain a major challenge. Recently, a new isolation protocol for highly tubular , also called f ullertubes, was reported. Herein, we describe spectroscopic characterization including C NMR, XPS, and Raman results for purified [5,5] fullertube family members, D-C and D-C. In addition, DFT computational HOMO-LUMO gaps, polarizability indices, and electron density maps were also obtained. The Raman and C NMR results are consistent with semiconducting and metallic properties for D-C and D-C, respectively. Our report suggests that short [5,5] fullertubes with aspect ratios of only ∼1.5-2 are metallic and could exhibit unique electronic properties.
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http://dx.doi.org/10.1021/jacs.0c11357DOI Listing
March 2021

Application of Mixed Reality Using Optical See-Through Head-Mounted Displays in Transforaminal Percutaneous Endoscopic Lumbar Discectomy.

Biomed Res Int 2021 16;2021:9717184. Epub 2021 Feb 16.

Department of Spine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Purpose: Mixed reality (MixR) technology merges the real and virtual worlds to produce new environments and visualizations; it is being tested for numerous minimally invasive surgical procedures. This study is aimed at evaluating the use of MixR technology using optical see-through head-mounted displays (OST-HMDs) during transforaminal percutaneous endoscopic discectomy (TPED).

Methods: Forty-four patients treated with MixR-assisted TPED through OST-HMDs were compared with matched patients treated with conventional TPED ( = 43). In the MixR-assisted TPED group, MixR technology was used to navigate the four procedures of marking, needle insertion, foraminoplasty, and positioning of the working sheath. The clinical outcomes were evaluated based on the numerical rating scale (NRS) scores and Oswestry Disability Index (ODI) on preoperative and postoperative day 1 and at the last follow-up examination. The procedural times, radiation exposure, and eye fatigue were also recorded. All patients were followed up for at least 6 months.

Results: The NRS scores and ODI were significantly improved in both groups at the last follow-up visit compared with the preoperative values ( < 0.05); these values were not statistically different between the groups. The operation time and radiation exposure during marking, needle insertion, and total procedure significantly decreased in the MixR-assisted TPED group compared to those in the conventional TPED group ( < 0.05). Unfortunately, the incidence of eye fatigue increased owing to the use of OST-HMDs in the MixR-assisted TPED group.

Conclusion: This study shows the utility of MixR technology for image guidance in conventional TPED. Radiation exposure is decreased, and this technology serves as a valuable tool during the TPED procedure; however, the assistance of conventional fluoroscopy is still required.
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http://dx.doi.org/10.1155/2021/9717184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902133PMC
May 2021

Heavy metal contamination in surface sediments from lakes and their surrounding topsoils of China.

Environ Sci Pollut Res Int 2021 Jun 7;28(23):29118-29130. Epub 2021 Feb 7.

School of Environment, Tsinghua University, Beijing, 100084, People's Republic of China.

Due to rapid urbanization, industrialization, agricultural development, and mining activities, soil heavy metal pollution has become a severe issue in China. To explore the regional heavy metal ecological risk of lake sediment and surrounding topsoil, we analyzed 237 lakes, with 1797 lake sediment sampling points and 1164 surrounding topsoil sampling points. Lower mean concentrations were detected for most heavy metals in soils than sediment (except for Hg). Cd and Hg in sediments and soils showed a more significant variation, with the coefficient of variation exceeding 110%. Linear regressions and Pearson's correlation analyses demonstrated that sediments and soils exhibited significant positive correlations. The principal heavy metals exceeding the Agricultural Soil Control Standard (ASCS) in sediments and soils were As and Cd, respectively. The Yunnan-Guizhou Plateau Lake Region (YGPLR) was the most seriously affected, exceeding the ASCS for Cd. The lakes with the most severe pollution were located in YGPLR impacted by the high background concentration of heavy metals in soil and mineral development activities. The Eastern Plain Lake Region, the Southeast Lake Region, and the Northeast Plain and Mountain Lake Region showed a clear anthropogenic impact. Lakes in the Inner Mongolia-Xinjiang Lake Region and the Tibetan Plateau Lake Region were estimated to have relatively low ecological risks due to their sparse population and slight environmental disturbance. The impact of geochemical factors on the ecological risk of heavy metals in lake sediments is more substantial than that of human activities at the regional scale.
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http://dx.doi.org/10.1007/s11356-020-12091-2DOI Listing
June 2021

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis.

Front Cell Dev Biol 2020 5;8:594509. Epub 2021 Jan 5.

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Iron overload is common in elderly people which is associated with an increased prevalence of osteoarthritis (OA), but the exact role of iron in the development of OA has not been established. The aim of the present study is to elucidate the connection between iron overload and OA using an iron overloaded mice model, as well as to explore the role of iron homeostasis, iron transporters dependent iron influx in OA pathogenesis. The iron overloaded mice model was established and OA was surgically induced. OA progression was assessed at 8 weeks after surgery. Next, primary chondrocytes were treated with pro-inflammatory cytokines and iron regulators mediated iron homeostasis were evaluated. Involvement of iron transporters was analyzed using chondrocytes mimicking an osteoarthritis-related phenotype . Iron overloaded mice exhibited greater cartilage destruction and elevated ADAMTS5 as well as MMP13 expression along with increased iron accumulation and dysregulated iron regulators. Pro-inflammatory cytokines could disturb cellular iron homeostasis via upregulating iron import proteins, TFR1 and DMT1, downregulating iron efflux protein FPN, thus result in cellular iron overload. Among iron transporters, DMT1 was found to play pivotal roles in iron overload induced OA progress. Inhibition of DMT1 suppressed IL-1β induced inflammatory response and ECM degradation via blockade of MAPK and PI3K/AKT/NF-κB pathways. Our results suggest that iron takes parts in the development of OA and cutting iron influx via inhibiting DMT1 activity could be an attractive new target for OA treatment.
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http://dx.doi.org/10.3389/fcell.2020.594509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813682PMC
January 2021

Unraveling the Formation Mechanism of a Hybrid Zr-Based Chemical Conversion Coating with Organic and Copper Compounds for Corrosion Inhibition.

ACS Appl Mater Interfaces 2021 Feb 19;13(4):5518-5528. Epub 2021 Jan 19.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York 11794, United States.

Environmentally friendly chromate-free, zirconium (Zr)-based conversion coating is a promising green technology for corrosion protection. Additives in the surface treatment provide critical functionalities and performance improvements; however, mechanistic understanding as to how the additives influence the coatings remains unclear. In this study, a new organic-inorganic hybrid Zr-based conversion coating combines copper (Cu) compounds and polyamidoamine (PAMAM), taking advantage of the complementary nature of organic and inorganic additives. A multimodal approach combining electron and X-ray characterization is applied to study the interaction of Cu and PAMAM and the resulting impacts on coating formation. Adding PAMAM changed the surface morphology, thickness, distribution of Cu in the clusters, and void formation of the coatings. High PAMAM (100-200 ppm) leads to little conversion coating formation, and low PAMAM (0-25 ppm) shows voids formation under the coatings. Moreover, PAMAM incorporates in the coating in the form of a PAMAM-Cu complex with a higher concentration toward the surface, providing an organic layer at the surface of the coating. X-ray absorption near-edge structure (XANES) spectroscopy shows the difference between the conventional and the hybrid coating treatments in an alkaline solution to simulate the E-coat process, suggesting the contribution of PAMAM in the enhanced chemical stability in an alkaline environment. Therefore, an intermediate range of addition of PAMAM (50 ppm) is optimal to (1) avoid excessive voids formation, (2) promote some Cu cluster formation and thus enhance the Zr-based coating formation, and (3) incorporate organic components into the coating to improve the adhesion of the subsequent coatings. Overall, this work furthers our knowledge on the formation mechanism of an effective and environmentally friendly hybrid conversion coating for corrosion inhibition, demonstrating a critical processing-structure-property relationship. This study will benefit future development of green and effective surface treatment technology.
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http://dx.doi.org/10.1021/acsami.0c19203DOI Listing
February 2021

Predictive formulae of ideal lumbar lordosis determined by individual pelvic incidence and thoracic kyphosis in asymptomatic adults.

J Orthop Sci 2021 Jan 5. Epub 2021 Jan 5.

Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. Electronic address:

Background: The precise prediction of ideal lumbar lordosis (LL) has become increasingly important in clinical practice. The aim of this study was to explore the regulatory mechanisms of sagittal spinopelvic alignment and to predict ideal LL based on individual pelvic incidence (PI) and thoracic kyphosis (TK) parameters in asymptomatic adults.

Methods: A total of 233 asymptomatic subjects older than 18 years were consecutively enrolled in our study between April 2017 and December 2019. A full-spine, standing X-ray was performed for each subject. The following parameters were measured in the sagittal plane: the apex of lumbar lordosis (LLA), the distance between the plumb line of the lumbar apex (LAPL) and the gravity plumb line, the inflection point (IP), LL, the upper arc and lower arc of lumbar lordosis (LLUA and LLLA, respectively), PI and TK. Stepwise multiple linear regressions were conducted, and the statistical significance level was P < 0.05.

Results: Both PI and TK were two important predictive variables for LLA, LAPL, IP and LL. In addition, the LLUA was mainly explained by TK, while the LLLA was explained by PI. The corresponding predictive models are listed as follows: LLA = 17.110 - 0.040∗PI + 0.023∗TK (R = 0.380), LAPL = 31.296 + 0.467∗PI - 0.126∗TK (R = 0.309), IP = 10.437 + 0.091∗TK - 0.029∗PI (R = 0.227), LL = 2.035 + 0.618∗PI + 0.430∗TK (R = 0.595), LLUA = 0.893 + 0.418∗TK (R = 0.598), LLLA = 3.543 + 0.576∗PI (R = 0.433).

Conclusion: The specific sagittal lumbar profile should be regulated by both pelvic and thoracic morphology. Such predictive models for lumbar parameters determined by individual PI and TK parameters have been established, which are meaningful for surgeons to better understand the regulatory mechanisms of sagittal spinopelvic alignment and reconstruct a satisfactory lumbar alignment.
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http://dx.doi.org/10.1016/j.jos.2020.11.022DOI Listing
January 2021

Radiographic anatomy and clinical significance of percutaneous endoscopic transforaminal oblique fixation from posterior corner in lumbar spine.

Ann Transl Med 2020 Nov;8(21):1391

Department of Spine Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Endoscopic transforaminal decompression and interbody fusion (ETDIF) has been widely discussed due to its advantages of less trauma, less bleeding, quick recovery, high safety, and relatively fewer complications, as well as adverse factors such as incomplete decompression, steep learning curve, low fusion rate, and high radiation risk. Furthermore, this technique requires the use of supplemental posterior pedicle-screw. Decompression, interbody fusion and percutaneous pedicle screw implantation are not completed in a single channel. Percutaneous endoscopic transforaminal oblique fixation from posterior corner in lumbar spine (PETOFPC) overcomes the above limitations. The purpose of this study is to confirm the anatomical feasibility for PETOFPC in the posterolateral transforaminal approach and to provide anatomic data for the design of new integrated fixable and fused interbody cage.

Methods: Sixty volunteers (22 men and 38 women) who underwent lumbar CT scans were collected and sent to the GEAW4.4 workstation. As a cohort study, the distances and angles of each path in the sagittal and axial planes were measured and analyzed statistically.

Results: The lengths of each path are not less than 40mm, and the longest can be up to 46mm. The paths in full-length group are about 5mm longer than that in medium group. PE (from point P to target E) path was the optimal path. The angles of each path were significantly different (P≤0.001), namely, a1 > a2 > a3, b1 > b2 > b3, and c1 < c2 < c3.

Conclusions: This study confirms anatomic feasibility for PETOFPC and provides anatomic data for the design of new integrated fixable and fused interbody cage. PETOFPC may be a very promising technology and have great clinical significance.
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http://dx.doi.org/10.21037/atm-20-2046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723534PMC
November 2020

Highly Efficient Electric-Field Control of Giant Rashba Spin-Orbit Coupling in Lattice-Matched InSb/CdTe Heterostructures.

ACS Nano 2020 Dec 10. Epub 2020 Dec 10.

School of Information Science and Technology, ShanghaiTech University, Shanghai 200031, China.

Spin-orbit coupling (SOC), the relativistic effect describing the interaction between the orbital and spin degrees of freedom, provides an effective way to tailor the spin/magnetic orders using electrical means. Here, we report the manipulation of the spin-orbit interaction in the lattice-matched InSb/CdTe heterostructures. Owing to the energy band bending at the heterointerface, the strong Rashba effect is introduced to drive the spin precession where pronounced weak antilocalization cusps are observed up to 100 K. With effective quantum confinement and suppressed bulk conduction, the SOC strength is found to be enhanced by 75% in the ultrathin InSb/CdTe film. Most importantly, we realize the electric-field control of the interfacial Rashba effect using a field-effect transistor structure and demonstrate the gate-tuning capability which is 1-2 orders of magnitude higher than other materials. The adoption of the InSb/CdTe integration strategy may set up a general framework for the design of strongly spin-orbit coupled systems that are essential for CMOS-compatible low-power spintronics.
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http://dx.doi.org/10.1021/acsnano.0c07598DOI Listing
December 2020

Gait Recognition Method of Underground Coal Mine Personnel Based on Densely Connected Convolution Network and Stacked Convolutional Autoencoder.

Entropy (Basel) 2020 Jun 21;22(6). Epub 2020 Jun 21.

School of Mechanical Electronic & Information Engineering, China University of Mining & Technology, Beijing 100083, China.

Biological recognition methods often use biological characteristics such as the human face, iris, fingerprint, and palm print; however, such images often become blurred under the limitation of the complex environment of the underground, which leads to low identification rates of underground coal mine personnel. A gait recognition method via similarity learning named Two-Stream neural network (TS-Net) is proposed based on a densely connected convolution network (DenseNet) and stacked convolutional autoencoder (SCAE). The mainstream network based on DenseNet is mainly used to learn the similarity of dynamic deep features containing spatiotemporal information in the gait pattern. The auxiliary stream network based on SCAE is used to learn the similarity of static invariant features containing physiological information. Moreover, a novel feature fusion method is adopted to achieve the fusion and representation of dynamic and static features. The extracted features are robust to angle, clothing, miner hats, waterproof shoes, and carrying conditions. The method was evaluated on the challenging CASIA-B gait dataset and the collected gait dataset of underground coal mine personnel (UCMP-GAIT). Experimental results show that the method is effective and feasible for the gait recognition of underground coal mine personnel. Besides, compared with other gait recognition methods, the recognition accuracy has been significantly improved.
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http://dx.doi.org/10.3390/e22060695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517229PMC
June 2020

Rational Design of Self-Assembled Cationic Porphyrin-Based Nanoparticles for Efficient Photodynamic Inactivation of Bacteria.

ACS Appl Mater Interfaces 2020 Dec 23;12(49):54378-54386. Epub 2020 Nov 23.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, P. R. China.

Bacterial infection has become an urgent health problem in the world. Especially, the evolving resistance of bacteria to antibiotics makes the issue more challenging, and thus new treatments to fight these infections are needed. Antibacterial photodynamic therapy (aPDT) is recognized as a novel and promising method to inactivate a wide range of bacteria with few possibilities to develop drug resistance. However, the photosensitizers (PSs) are not effective against Gram-negative bacteria in many cases. Herein, we use conjugated -tetra(4-carboxyphenyl)porphine (TCPP) and triaminoguanidinium chloride (TG) to construct self-assembled cationic TCPP-TG nanoparticles (NPs) for efficient bacterial inactivation under visible light illumination. The TCPP-TG NPs can rapidly adhere to both Gram-negative and Gram-positive bacteria and display promoted singlet oxygen (O) generation compared with TCPP under light irradiation. The high local positive charge density of TCPP-TG NPs facilitates the interaction between the NPs and bacteria. Consequently, the TCPP-TG NPs produce an elevated concentration of local O under light irradiation, resulting in an extraordinarily high antibacterial efficiency (99.9999% inactivation of the representative bacteria within 4 min). Furthermore, the TCPP-TG NPs show excellent water dispersity and stability during 4 months of storage. Therefore, the rationally designed TCPP-TG NPs are a promising antibacterial agent for effective aPDT.
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http://dx.doi.org/10.1021/acsami.0c15244DOI Listing
December 2020

Effect of Double Transition Metal Salt Catalyst on Fushun Oil Shale Pyrolysis.

Scanning 2020 4;2020:6685299. Epub 2020 Nov 4.

CAS Key Laboratory of Nuclear Materials and Safety Assessment, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.

Shale ash (SA) as the carrier, the ratio of Cu to Ni in the Cu-Ni transition metal salt being, respectively, 1 : 0, 2 : 1, 1 : 1, 1 : 2, 0 : 1, the double transition metal salt catalyst (CuNi/SA) was prepared to explore the effect of such catalysts on the pyrolysis behavior and characteristics of Fushun OS. The research results show that the temperature ( ) corresponding to the maximum weight loss rate decreased by 12.9°C, 4.0°C, and 3.6°C; and the apparent activation energy decreased by 35.2%, 33.9%, and 29.6%, respectively, after adding catalysts CuNi/SA in pyrolysis. The addition of CuNi/SA and CuNi/SA further improves the shale oil (SO) yield of 3.5% and 3.1%, respectively. CuNi/SA produces more aromatic hydrocarbons, which, however, weakens the stability of SO and is of toxicity in use. After analyzing the pyrolysis product-semicoke (SC) and SO-with ATR-FTIR and GC-MS methods, CuNi/SA promotes the secondary cracking and aromatization of OS pyrolysis, increasing the content of the compound of olefins and aromatics in SO, and hastening the decomposition of long-chain aliphatic hydrocarbons to short-chain aliphatic hydrocarbons.
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http://dx.doi.org/10.1155/2020/6685299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657698PMC
November 2020

Antioxidant activity and functional properties of Alcalase-hydrolyzed scallop protein hydrolysate and its role in the inhibition of cytotoxicity in vitro.

Food Chem 2021 May 6;344:128566. Epub 2020 Nov 6.

School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; National Engineering Research Center of Seafood, Dalian 116034, PR China.

Three scallop protein hydrolysates (SPH) were obtained by enzymatic hydrolysis of scallop meal by Pepsin, Dispase and Alcalase, respectively. The antioxidant activities of the SPHs were characterized for their free radical scavenging activities through 1,1-diphenyl-2-picrylhydrazyl (DPPH)/hydroxyl/2,2' azino-bis-3-(ethylbenzthiazoline-6-sulphonic acid) (ABTS) assays, showing at least 60% radicals scavenging activities in samples (10 mg/mL). Moreover, the Alcalase-hydrolyzed SPH (ASPH) was shown to have the highest free radical scavenging activity determined by Electron Spin Resonance (ESR), due to the high proportion of antioxidant amino acids (35.25%) and better solubility. In addition, the ASPH also exhibited promising inhibitory effects (30-40%) against lipid oxidation in emulsifying system and excellent emulsifying and foaming properties. In vitro, the ASPH exhibited protective effects (nearly 20%) against HO-induced cytotoxicity probably due to the inhibition of mitochondria-associated generation of reactive oxygen species (ROS). The ASPH may potentially serve as a high-valued scallop-based food additive with great health benefits.
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http://dx.doi.org/10.1016/j.foodchem.2020.128566DOI Listing
May 2021

Prespecified-time synchronization of switched coupled neural networks via smooth controllers.

Neural Netw 2021 Jan 16;133:32-39. Epub 2020 Oct 16.

School of Mathematics, Southeast University, Nanjing 210096, China; Yonsei Frontier Lab, Yonsei University, Seoul, Korea. Electronic address:

This paper considers the prespecified-time synchronization issue of switched coupled neural networks (SCNNs) under some smooth controllers. Different from the traditional finite-time synchronization (FTS), the synchronization time obtained in this paper is independent of control gains, initial values or network topology, which can be pre-set as to the task requirements. Moreover, unlike the existing nonsmooth or even discontinuous FTS control strategies, the new proposed control protocols are fully smooth, which abandon the common fractional power feedbacks or signum functions. Finally, two illustrative examples are provided to illustrate the effectiveness of the theoretical results.
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http://dx.doi.org/10.1016/j.neunet.2020.10.007DOI Listing
January 2021

Nano- to microscale three-dimensional morphology relevant to transport properties in reactive porous composite paint films.

Sci Rep 2020 Oct 27;10(1):18320. Epub 2020 Oct 27.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA.

The quantitative evaluation of the three-dimensional (3D) morphology of porous composite materials is important for understanding mass transport phenomena, which further impact their functionalities and durability. Reactive porous paint materials are composites in nature and widely used in arts and technological applications. In artistic oil paintings, ambient moisture and water and organic solvents used in conservation treatments are known to trigger multiple physical and chemical degradation processes; however, there is no complete physical model that can quantitatively describe their transport in the paint films. In the present study, model oil paints with lead white (2PbCO·Pb(OH)) and zinc white (ZnO) pigments, which are frequently found in artistic oil paintings and are associated with the widespread heavy metal soap deterioration, were studied using synchrotron X-ray nano-tomography and unilateral nuclear magnetic resonance. This study aims to establish a relationship among the paints' compositions, the 3D morphological properties and degradation. This connection is crucial for establishing reliable models that can predict transport properties of solvents used in conservation treatments and of species involved in deterioration reactions, such as soap formation.
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http://dx.doi.org/10.1038/s41598-020-75040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591493PMC
October 2020
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