Dr. Xiaoyan Sun, PhD - Karolinska Institutet

Dr. Xiaoyan Sun

PhD

Karolinska Institutet

Stockholm | Sweden

Dr. Xiaoyan Sun, PhD - Karolinska Institutet

Dr. Xiaoyan Sun

PhD

Introduction

Primary Affiliation: Karolinska Institutet - Stockholm , Sweden

Research Interests:

Publications

6Publications

96Reads

-Profile Views

112PubMed Central Citations

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.

Cell Metab 2016 10 22;24(4):593-607. Epub 2016 Sep 22.

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, 171 77 Stockholm, Sweden; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, 141 57 Huddinge, Sweden; Ludwig Institute for Cancer Research, 171 77 Stockholm, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2016.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069352PMC
October 2016
24 Reads
82 Citations
17.570 Impact Factor

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.

Cell Syst 2016 09 15;3(3):221-237.e9. Epub 2016 Sep 15.

Department of Biosciences and Nutrition and Center for Innovative Medicine, Karolinska Institutet, Novum, 141 83 Huddinge, Sweden. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24054712163026
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052454PMC
http://dx.doi.org/10.1016/j.cels.2016.08.010DOI Listing
September 2016
35 Reads
19 Citations

Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population.

Biosci Biotechnol Biochem 2014 10;78(11):1805-12. Epub 2014 Jul 10.

a Chemical Kinomics Research Center , Korea Institute of Science and Technology , Seoul , Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09168451.2014.932666DOI Listing
August 2015
9 Reads
1 Citation
1.063 Impact Factor

Low stability and a conserved N-glycosylation site are associated with regulation of the discoidin domain receptor family by glucose via post-translational N-glycosylation.

Biosci Biotechnol Biochem 2013 7;77(9):1907-16. Epub 2013 Sep 7.

Future Fusion Research Division, Korea Institute of Science and Technology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1271/bbb.130351DOI Listing
April 2014
13 Reads
3 Citations
1.063 Impact Factor

LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.

J Pharmacol Exp Ther 2012 Mar 29;340(3):510-9. Epub 2011 Nov 29.

Korea Institute of Science and Technology, 39-1, Hawolgok-Dong, Sungbuk-Ku, Seoul 136-791, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.111.187328DOI Listing
March 2012
15 Reads
7 Citations
3.972 Impact Factor

A high-efficiency, two-dimensional gel electrophoresis platform for mature leaves of grass pea (Lathyrus sativus L.)

Acta Physiol Plant (2011) 33: 2387.

Acta Physiologiae Plantarum

Grass pea (Lathyrus sativus L.) is the most drought-tolerant legume crop rich in dietary protein. However, little is known about the molecular mechanisms of its drought resistance. Two-dimensional gel electrophoresis (2-DE) is an important experiment technique in proteomics, which has been applied extensively in studies on plant resistance to abiotic stress. To establish an effective 2-DE platform and further study the drought-resistance mechanisms of grass pea using proteomic approaches, three protein extraction methods, different isoelectric focusing (IEF) conditions and various types of gel strips were evaluated using mature leaves. The results showed that the trichloroacetic acid (TCA)/acetone protein extraction method, extending time at low voltage for IEF and using 18 cm gel strip with pH 4.0–7.0 were optimum conditions for 2-DE analysis of grass pea leaves. Applying these optimized 2-DE conditions, 1,481 total protein spots were detected in control leaves and 1,346 spots in polyethylene glycol -treated leaves, of which 67 differentially expressed protein spots were obtained relative to the control. These data suggested that an efficient 2-DE platform with high repeatability and resolution for grass pea mature leaves had been established for the first time here, which could be further used to investigate the drought-resistance molecular mechanisms of grass pea.

View Article
November 2011
8 Reads

Top co-authors

Beom-Seok Yang
Beom-Seok Yang

Korea Institute of Science and Technology

3
Trong Nhat Phan
Trong Nhat Phan

Chosum University

3
Maria Kasper
Maria Kasper

Karolinska Institutet

2
Seung Hee Jung
Seung Hee Jung

Ewha Womans University

2
Tae Kyo Park
Tae Kyo Park

LegoChem Biosciences

1
Sung Ho Woo
Sung Ho Woo

Institute of Fisheries Sciences

1
Sten Linnarsson
Sten Linnarsson

Karolinska Institutet

1
Hyangsook Lee
Hyangsook Lee

Kyung Hee University

1