Publications by authors named "Xiaoyan Li"

1,303 Publications

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Assessment of Two Formulations of Triptorelin in Chinese Patients with Endometriosis: A Phase 3, Randomized Controlled Trial.

Adv Ther 2022 Aug 10. Epub 2022 Aug 10.

Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Introduction: This phase 3, randomized, open-label, active-controlled, multicenter study investigated the efficacy of triptorelin pamoate prolonged-release (PR) 3-month in Chinese patients with endometriosis by demonstrating the noninferiority of the 3-month formulation to the standard of care, triptorelin acetate PR 1-month.

Methods: The trial was conducted in 24 clinical centers in China, and included 300 Chinese women (18-45 years) with endometriosis and regular menstrual cycles who required treatment with a gonadotropin-releasing hormone agonist for 6 months. One group of patients (n = 150) was treated with triptorelin pamoate PR 3-month (15 mg per injection, once every 12 weeks), and the other (n = 150) with triptorelin acetate PR 1-month (3.75 mg per injection, once every 4 weeks). The primary outcome measure was the proportion of patients with estradiol (E2) concentrations suppressed to castration levels (≤ 184 pmol/L, or 50 pg/mL) after 12 weeks of treatment.

Results: Triptorelin pamoate PR 3-month was noninferior to triptorelin acetate PR 1-month for the treatment of endometriosis: over 98% of patients in both groups were chemically castrated at week 12. Both formulations were also equally efficacious in reducing endometriosis-associated pelvic pain, and reducing serum concentrations of E2, luteinizing hormone, and follicle-stimulating hormone over time. No new safety concerns were identified.

Conclusion: Triptorelin pamoate PR 3-month is a valid alternative to triptorelin acetate PR 1-month for the treatment of Chinese women with endometriosis, with fewer injections and a potentially lower burden of care.

Trial Registration: NCT03232281.
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http://dx.doi.org/10.1007/s12325-022-02264-5DOI Listing
August 2022

Development of ecological risk assessment for Diisobutyl phthalate and di-n-octyl phthalate in surface water of China based on species sensitivity distribution model.

Chemosphere 2022 Aug 5:135932. Epub 2022 Aug 5.

Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Hong Kong, China.

Phthalic acid esters (PAEs) are commonly used as plasticizer and are emerging concern worldwide for potent adverse effects of aquatic organisms. Certain PAEs were often detected in different environmental matrices but related toxicity data were still lacking to support their risk assessment. The study investigated the acute toxicity of Diisobutyl phthalate (DiBP) and Di-n-octyl phthalate (DnOP) using 6 Chinese resident aquatic organisms from 3 phyla and 6 species and constructed the species sensitivity distribution (SSD) models for ecological risk assessment. Lethal concentration 50% (LC) ranges of DiBP and DnOP were 4.89-21.45 mg/L and 1.45-1200 mg/L, respectively. The derived acute and chronic predicted no-effect concentrations (PNECs) based on log-normal model of water were 0.54 and 0.04 mg/L for DiBP and 0.23 and 0.05 mg/L for DnOP, respectively. The ERA for DiBP and DnOP in the surface water and sediment of China was conducted. Water samples of Haihe Rive (RQ = 0.41) and Hun River (RQ = 0.16) of DiBP showed medium risk. And sediment samples of Yellow River (RQ = 0.71) and Chao Hu Lake (RQ = 0.42) of DiBP showed medium risk. Meanwhile, the above water and sediment samples (RQ<0.1) of DnOP showed low risk.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135932DOI Listing
August 2022

A simple pre-disease state prediction method based on variations of gene vector features.

Comput Biol Med 2022 Jul 19;148:105890. Epub 2022 Jul 19.

Department of Computer Science, Rogers School of Engineering and Computer Science, Baylor University, TX, 76798, Waco, USA. Electronic address:

Background: The progression of disease can be divided into three states: normal, pre-disease, and disease. Since a pre-disease state is the tipping point of disease deterioration, accurately predicting pre-disease state may help to prevent the progression of disease and develop feasible treatment in time.

Methods: In the perspective of gene regulatory network, the expression of a gene is regulated by its upstream genes, and then it also regulates that of its downstream genes. In this study, we define the expression value of these genes as a gene vector to depict its state in a specific sample. Then, we propose a novel pre-disease prediction method by such vector features.

Results: The results of an influenza virus infection dataset show that our method can successfully predict the pre-disease state. Furthermore, the pre-disease state related genes predicted by our methods are highly associated with each other and enriched in influenza virus infection related pathways. In addition, our method is more time efficient in calculation than previous works. The code of our method is accessed at https://github.com/ZhenshenBao/sPGVF.git.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105890DOI Listing
July 2022

Noncovalent interactions between benzochalcogenadiazoles and nitrogen bases.

J Mol Model 2022 Aug 6;28(9):248. Epub 2022 Aug 6.

College of Chemistry and Materials Science, Hebei Key Laboratory of Inorganic Nano-materials, Hebei Normal University, Shijiazhuang, 050024, People's Republic of China.

A theoretical study has been carried out on the intermolecular interactions between tetrafluoro-benzochalcogenadiazoles (chalcogen = S, Se, Te) and a series of nitrogen bases (FCN, ClCN, NP, trans-NH, pyridine, pyrazole, imidazole) at the B97-D3/def2-TZVP level, to obtain a better insight into the nature and strength of Ch···N chalcogen bond and secondary interaction in the binary and 1:2 ternary complexes. The dispersion force plays a prominent role on the stability of the sulfur complexes, and the electrostatic effect enhanced for the heavier chalcogen complexes. Most of intermolecular bonds display the characters of closed-shell and noncovalent interaction. For the complexes involving pyridine and imidazole, chalcogen bond is stronger than hydrogen bond, while the strength of chalcogen bond is equivalent to the secondary interaction for other complexes. With the addition of nitrogen base in the 1:2 complexes, chalcogen bond is weakened, while the secondary interaction remains unchanged. In the 1:2 complexes formed by pyridine and imidazole, stronger chalcogen bond results in larger negative cooperativity than that of other complexes.
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http://dx.doi.org/10.1007/s00894-022-05247-zDOI Listing
August 2022

Combination of chemically modified SDF-1α mRNA and small skin improves wound healing in diabetic rats with full-thickness skin defects.

Cell Prolif 2022 Aug 6:e13318. Epub 2022 Aug 6.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objectives: Diabetes mellitus is associated with refractory wound healing, yet current therapies are insufficient to accelerate the process of healing. Recent studies have indicated chemically modified mRNA (modRNA) as a promising therapeutic intervention. The present study aimed to explore the efficacy of small skin engineered to express modified mRNAs encoding the stromal cell-derived factor-1α (SDF-1α) facilitating wound healing in a full-thickness skin defect rat model. This study, devised therapeutic strategies for diabetic wounds by pre-treating small skin with SDF-1α modRNA.

Materials And Methods: The in vitro transfection efficiency was evaluated using fluorescence microscopy and the content of SDF-1α in the medium was determined using ELISA after the transfection of SDF-1α into the small skin. To evaluate the effect of SDF-1α modRNA and transplantation of the small skin cells on wound healing, an in vivo full-thickness skin defect rat model was assessed.

Results: The results revealed that a modRNA carrying SDF-1α provided potent wound healing in the small skin lesions reducing reduced scar thickness and greater angiogenesis (CD31) in the subcutaneous layer. The SDF-1α cytokines were significantly secreted by the small skin after transfection in vitro.

Conclusions: This study demonstrated the benefits of employing small skin combined with SDF-1α modRNA in enhancing wound healing in diabetic rats having full-thickness skin defects.
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http://dx.doi.org/10.1111/cpr.13318DOI Listing
August 2022

FERONIA is involved in the phototropin 1-mediated blue light phototropic growth in Arabidopsis.

J Integr Plant Biol 2022 Aug 4. Epub 2022 Aug 4.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, and Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation, Hunan University, Changsha, 410082, China.

Plant shoot phototropism is triggered by the formation of a light-driven auxin gradient leading to bending growth. The blue light receptor phototropin 1 (phot1) senses light direction, but how this leads to auxin gradient formation and growth regulation remains poorly understood. Previous studies have suggested phot1's role for regulated apoplastic acidification, but its relation to phototropin and hypocotyl phototropism is unclear. Herein, we show that blue light can cause phot1 to interact with and phosphorylate FERONIA (FER), a known cell growth regulator, and trigger downstream phototropic bending growth in Arabidopsis hypocotyls. fer mutants showed defects in phototropic growth, similar to phot1/2 mutant. FER also interacts with and phosphorylates phytochrome kinase substrates (PKSs), the phot1 downstream substrates. The phot1-FER pathway acts upstream of apoplastic acidification and the auxin gradient formation in hypocotyl under lateral blue light, both of which are critical for phototropic bending growth in hypocotyls. Our study highlights a pivotal role of FER in the phot1-mediated phototropic cell growth regulation in plants. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1111/jipb.13336DOI Listing
August 2022

The role of halogen bonds in the catalytic mechanism of the iso-Nazarov cyclization reaction: a DFT study.

Phys Chem Chem Phys 2022 Aug 10;24(31):18877-18887. Epub 2022 Aug 10.

College of Chemistry and Materials Science, Hebei Key Laboratory of Inorganic Nano-materials, Hebei Normal University, Shijiazhuang, 050024, China.

With the continuous development of halogen bonds, halogen bond donors have been used as clean and efficient catalysts in organic reactions. In this work, with inorganic halides (I, IBr, ICl, and ICl) as catalysts and the iso-Nazarov cyclization as the benchmark reaction, we aim at investigating the role of the halogen bond in the catalytic mechanism. The halogen bond catalyzed iso-Nazarov cyclization reaction involves three steps: carbon-carbon coupling process, [1,2]-H shift process, and [1,4]-H shift process. The halogen-bonding interaction promotes the charge accumulation of the oxygen atom in the carbonyl group and decreases the activation energy of the reaction. The catalytic activity of the halogen bond donor is enhanced in the order of I < IBr < ICl < ICl, and it could be predicted that the partial covalent interaction of the I⋯O halogen bond between the catalyst ICl and the oxygen atom of the reactant may exhibit good catalytic activity in the experiments. In the [1,4]-H shift process, the two-step hydrogen bond/halogen bond co-catalyzed mechanism exhibits the lowest reaction energy barrier than the one-step water co-catalyzed proton transfer mechanism and the direct one.
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http://dx.doi.org/10.1039/d2cp01913bDOI Listing
August 2022

Cyclic hematuria after cesarean section: MRI image indicates vesico-uterine fistula.

Arch Gynecol Obstet 2022 Jul 30. Epub 2022 Jul 30.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1007/s00404-022-06707-wDOI Listing
July 2022

Advances in the Therapeutic Effects of Apoptotic Bodies on Systemic Diseases.

Int J Mol Sci 2022 Jul 26;23(15). Epub 2022 Jul 26.

Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China.

Apoptosis plays an important role in development and in the maintenance of homeostasis. Apoptotic bodies (ApoBDs) are specifically generated from apoptotic cells and can contain a large variety of biological molecules, which are of great significance in intercellular communications and the regulation of phagocytes. Emerging evidence in recent years has shown that ApoBDs are essential for maintaining homeostasis, including systemic bone density and immune regulation as well as tissue regeneration. Moreover, studies have revealed the therapeutic effects of ApoBDs on systemic diseases, including cancer, atherosclerosis, diabetes, hepatic fibrosis, and wound healing, which can be used to treat potential targets. This review summarizes current research on the generation, application, and reconstruction of ApoBDs regarding their functions in cellular regulation and on systemic diseases, providing strong evidence and therapeutic strategies for further insights into related diseases.
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http://dx.doi.org/10.3390/ijms23158202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331698PMC
July 2022

Cell damage repair mechanism in a desert green algae Chlorella sp. against UV-B radiation.

Ecotoxicol Environ Saf 2022 Jul 22;242:113916. Epub 2022 Jul 22.

Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

The protective ozone layer is continually depleting owing to an increase in the levels of solar UV-B radiation, which has harmful effects on organisms. Algae in desert soil can resist UV-B radiation, but most research on the radiation resistance of desert algae has focused on cyanobacteria. In this study, we found that desert green algae, Chlorella sp., could maintain high photosynthetic activity under UV-B stress. To examine the tolerance mechanism of the desert green algae photosystem, we observed the physiological and transcriptome-level responses of Chlorella sp. to high doses of UV-B radiation. The results showed that the reactive oxygen species (ROS) content first increased and then decreased, while the malondialdehyde (MDA) content revealed no notable lipid peroxidation during the UV-B exposure period. These results suggested that Chlorella sp. may have strong system characteristics for scavenging ROS. The antioxidant enzyme system showed efficient alternate coordination, which exhibited a protective effect against enhanced UV-B radiation. DNA damage and the chlorophyll and soluble protein contents had no significant changes in the early irradiation stage; UV-B radiation did not induce extracellular polysaccharides (EPS) synthesis. Transcriptomic data revealed that a strong photosynthetic system, efficient DNA repair, and changes in the expression of genes encoding ribosomal protein (which aid in protein synthesis and improve resistance) are responsible for the high UV-B tolerance characteristics of Chlorella sp. In contrast, EPS synthesis was not the main pathway for UV-B resistance. Our results revealed the potential cell damage repair mechanisms within Chlorella sp. that were associated with high intensity UV-B stress, thereby providing insights into the underlying regulatory adaptations of desert green algae.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113916DOI Listing
July 2022

Photodegradation and Photostability of Bamboo: Recent Advances.

ACS Omega 2022 Jul 6;7(28):24041-24047. Epub 2022 Jul 6.

Department of Efficient Utilization of Bamboo and Wood, China National Bamboo Research Center, Wenyi Road 310, Hangzhou 310012, China.

Bamboo and its products are widely used in indoor and outdoor fields. Photodegradation occurs easily on the surface when bamboo is exposed to ultraviolet (UV) light from solar radiation. This induces surface discoloration and degrades the physical properties of bamboo, which not only negatively affects its utility and aesthetic characteristics but also restricts its application in outdoor environments. In this work, we review the mechanism of bamboo photodegradation, in which the behavior of lignin is key. The changes in bamboo's microstructure, surface color, and chemical composition during photodegradation are described in detail. Methods for enhancing its photostability, including the application of transparent coatings containing UV absorbers and hindered amine light stabilizer compounds on bamboo surfaces, are then systematically summarized, and potential approaches to combat the photodegradation of bamboo surfaces are discussed. On the basis of the recent advances of photodegradation and photostability of bamboo, this review provides new insights into the scientific application and protection of bamboo in the outdoor field.
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http://dx.doi.org/10.1021/acsomega.2c02035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301731PMC
July 2022

Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.

Open Med (Wars) 2022 6;17(1):1183-1202. Epub 2022 Jul 6.

Department of Blood Transfusion, Shanxi Province People's Hospital, No. 29 Shuangtasi Street, Yingze District, Taiyuan, Shanxi, 030012, China.

The function of small ubiquitin-like modifier (SUMO)-related genes in hepatocellular carcinoma (HCC) remains unclear. This study aimed to analyze the expression profile and prognostic relevance of SUMO-related genes using publicly available data. A set of bioinformatics tools and experiments were integrated to explore the mechanism of the genes of interest. The least absolute shrinkage and selection operator Cox regression analysis was used to construct a prognostic model. SUMO-2 and SUMO-activating enzyme subunit 1 (SAE1) were upregulated in HCC. The enrichment analysis indicated that SUMO-2 and SAE1 might regulate the cell cycle. The downregulation of SAE1 inhibited the proliferation of HCC cells, whereas the upregulation of the gene promoted cell proliferation. IGF2BP3 contributed to the upregulation of SAE1 in an N6-methyladenosine (m6A)-dependent way. Eventually, an SAE1-related risk score (SRRS) was developed and validated in HCC. SRRS could serve as an independent prognostic factor and predict the efficiency of transarterial chemoembolization in patients with HCC.
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http://dx.doi.org/10.1515/med-2022-0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263891PMC
July 2022

A novel classification and grading scale of palatine tonsil anatomy in children.

Eur Arch Otorhinolaryngol 2022 Jul 19. Epub 2022 Jul 19.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 355, Luding Road, Shanghai, 200062, People's Republic of China.

Purpose: The influence of tonsil anatomical differences on post-tonsillectomy hemorrhage and pain has not been studied yet. This study aimed to establish a classification and grading scale of palatine tonsil anatomy, not size, for personalized post-tonsillectomy care.

Methods: Between August 2020 and August 2021, 337 children who underwent extracapsular tonsillectomy were recruited. The images of tonsil anatomy during the surgery were recorded and then classified and graded. Postoperative hemorrhage was recorded, and the degree of pain was measured using a visual analog scale (VAS). The primary outcomes were the associations between postoperative hemorrhage, pain, and the classification and grade of tonsil anatomy, analyzed by univariable and multivariable analyses.

Results: 186 of the 337 patients (55.2%) were male and 151 (44.8%) were female; the mean age was 5.59 years. The overall postoperative hemorrhage rate was 4.1%. The mean postoperative VAS score was 4.96. By univariable analysis with logistic regression model, significant associations were found between postoperative hemorrhage and the grade 2 and grade 3 tonsillar lower pole, and grade 3 tonsillar bed. Multivariable analysis with binary logistic regression model also revealed significant associations between postoperative hemorrhage and the grade 2 and grade 3 lower pole (OR: 8.23, 95% CI 1.01-67.37, P = 0.049; OR: 23.86, 95% CI 2.22-56.47, P = 0.009, respectively) and grade 3 tonsillar bed (OR: 14.25, 95% CI 1.46-18.75, P = 0.022). Linear regression analysis showed the associations between postoperative pain and grade 2 and grade 3 lower pole (β: 0.88, 95% CI 0.31-1.32, P = 0.002; β: 1.56, 95% CI 1.29-3.29, P = 0.001, respectively) and grade 3 anterior surface (β: 0.85, 95% CI 0.30-3.07, P = 0.004). Age and upper pole were not associated with the postoperative hemorrhage and pain neither.

Conclusion: In the present study, we established a novel classification and 3-grade scale of palatine tonsil anatomy, based on upper pole, anterior surface, lower pole, and tonsillar bed. Furthermore, we revealed for the first time that some anatomical characteristics of tonsils were associated with post-tonsillectomy complications.
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http://dx.doi.org/10.1007/s00405-022-07515-3DOI Listing
July 2022

Exploring the potential targets of Sanshimao formula for hepatocellular carcinoma treatment by a method of network pharmacology combined with molecular biology.

J Ethnopharmacol 2022 Jul 15;297:115531. Epub 2022 Jul 15.

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Naval Military Medical University, Shanghai, China. Electronic address:

Ethnopharmacological Relevance: The Sanshimao (SSM) formula is an effective prescription for hepatocellular carcinoma (HCC) therapy in the clinical setting. This prescription is made up of four herbals, Maorenshen, Shijianchuan, Shishangbai and Shidachuan, which are used for detoxification and removing blood stasis. However, its mechanism in the treatment of HCC remains ambiguous.

Aim Of The Study: To explore the potential targets of SSM against HCC by network pharmacology analysis and verify the data using molecular biological methods.

Materials And Methods: We screened active components and potential targets by data mining, constructed a network, and performed functional analysis and pathway enrichment to explore the therapeutic targets of SSM for HCC treatment. Then, the effects of SSM on HCC cells were studied to validate the data from network pharmacology analysis.

Results: Eighty-eight common targets were obtained by mapping 932 HCC-related genes, and 325 targets corresponded to 11 active components of SSM. They were enriched in various biological processes, such as the response to inorganic substances, response to toxic substances and apoptotic signalling pathway, and multi-pathways involved pathways in cancer, EGFR tyrosine kinase inhibitor resistance, and AGE-RAGE signalling pathway in diabetic complications, as evaluated by the analysis of advanced functions and pathways. TP53, JUN, HSP90AA1, EGFR, AR and MAPK1 might be the core targets closely related to the effects of SSM on HCC according to PPI analysis. Treatment with SSM decreased cell viability and migration, promoted apoptosis and inhibited the EGFR/FAK/AKT signalling pathway.

Conclusion: This research preliminarily indicates that SSM treats HCC via multiple components and pathways. EGFR/FAK/AKT are promising therapeutic targets of SSM for HCC treatment. This provides objective evidence for further mechanistic research and the future development and clinical application of SSM in HCC patients.
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http://dx.doi.org/10.1016/j.jep.2022.115531DOI Listing
July 2022

Challenges and tissue engineering strategies of periodontal guided tissue regeneration.

Tissue Eng Part C Methods 2022 Jul 15. Epub 2022 Jul 15.

Capital Medical University School of Stomatology, Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction,, Tian Tan Xi Li No.4, Beijing, Beijing , China, 100050;

Periodontitis is a chronic infectious oral disease with a high prevalence rate in the world, and is a major cause of tooth loss. Nowadays, people have realized that the local microenvironment that includes proteins, cytokines, and extracellular matrix has a key influence on the functions of host immune cells and periodontal ligament stem cells during a chronic infectious disease such as periodontitis. The above pathological process of periodontitis will lead to a defect of periodontal tissues. Through the application of biomaterials, biological agents, and stem cells therapy, guided tissue regeneration (GTR) makes it possible to reconstruct healthy periodontal ligament tissue after local inflammation control. To date, substantial advances have been made in periodontal guided tissue regeneration. However, the process of periodontal remodeling experiences complex microenvironment changes, and currently periodontium regeneration still remains to be a challenging feat. In this review, we summarized the main challenges in each stage of periodontal regeneration, and try to put forward appropriate biomaterial treatment mechanisms or potential tissue engineering strategies that provide a theoretical basis for periodontal tissue engineering regeneration research.
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http://dx.doi.org/10.1089/ten.TEC.2022.0106DOI Listing
July 2022

[Study on CT features of congenital branchial cleft anomaly in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;36(6):441-447

Department of Otolaryngology Head and Neck Surgery,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao tong University.

To summarize the CT features of congenital branchial cleft anomaly in children, to reduce misdiagnosis and improve surgical strategy. This study enrolled 323 pediatric patients with congenital first branchial cleft anomaly, congenital second branchial cleft anomaly and congenital piriform sinus fistula confirmed by surgery and post-operative histopathology, who was admitted to Shanghai Children's hospital from August 2014 to January 2021., CT imaging data were retrospectively analyzed. A total of 323 children with congenital branchial cleft deformity were included. There were 145 males and 178 females, aged from 22 days to 15 years. 119(119/323, 36.8%) cases were diagnosed as congenital first branchial cleft anomaly. Among them, 96 cases(96/119, 80.67%) were related to the wall of external auditory canal, and 89 cases(89/119, 74.78%) were related to parotid gland. The positive rate of CT examination was 87.4%(104/119). 57 cases(57 / 323, 17.6%) had congenital second branchial cleft anomaly. Among them, 46 cases(46/57, 80.7%) were related to submandibular gland. The positive rate of CT examination was 84.2%(48/57). 147 cases(147/323, 45.5%) had congenital piriform sinus fistula, in which 129 cases(129/147, 87.8%) were related to thyroid. The positive rate of CT was 89.1%(131/147). The CT findings of congenital first branchial cleft anomaly are characterized by lesions in the inferior and/or posterior wall of ipsilateral external auditory canal and parotid gland. The CT features of congenital second branchial cleft anomaly are that the lesion is located on the ipsilateral submandibular gland (posterior and medial). The CT features of congenital piriform sinus fistula are that the focus is located on the dorsal side of the upper pole of the lateral lobe of the thyroid gland.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2022.06.007DOI Listing
June 2022

Changes in Chemical and Thermal Properties of Bamboo after Delignification Treatment.

Polymers (Basel) 2022 Jun 24;14(13). Epub 2022 Jun 24.

College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, China.

Bamboo delignification is a common method for studying its functional value-added applications. In this study, bamboo samples were delignified by treatment with sodium chlorite. The effects of this treatment on the bamboo's microstructure, surface chemical composition, and pyrolysis behaviour were evaluated. Field-emission scanning electron microscopy (FE-SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) were conducted to evaluate these parameters. The FTIR results demonstrated that the lignin peak decreased or disappeared, and some hemicellulose peaks decreased, indicating that sodium chlorite treatment effectively removed lignin and partly decomposed hemicellulose, although cellulose was less affected. The XPS results showed that, after treatment, the oxygen-to-carbon atomic ratio of delignified bamboo increased from 0.34 to 0.45, indicating a lack of lignin. XRD revealed increased crystallinity in delignified bamboo. Further pyrolysis analysis of treated and untreated bamboo showed that, although the pyrolysis stage of the delignified bamboo did not change, the maximum thermal degradation rate (R) and its corresponding temperature (from 353.78 to 315.62 °C) decreased significantly, indicating that the pyrolysis intensity of the bamboo was weakened after delignification. Overall, this study showed that delignified bamboo develops loose surfaces, increased pores, and noticeable fibres, indicating that alkali-treated bamboo has promising application potential due to its novel and specific functionalities.
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http://dx.doi.org/10.3390/polym14132573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9269071PMC
June 2022

Clinical effectiveness of treating laryngotracheal stenosis with free hyoid bone reconstruction of the cricoid cartilage: A case series.

Int J Pediatr Otorhinolaryngol 2022 Jul 3;160:111227. Epub 2022 Jul 3.

Department of Otolaryngology and Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200062, China. Electronic address:

We reported the free hyoid bone reconstruction of the cricoid cartilage to treat LTS in children. This retrospective case series study included LTS children who underwent hyoid bone separation and T tube implantation. Thirty-four children were included. Twenty-five children were with good outcomes after free hyoid bone reconstruction of the cricoid cartilage. Specifically, the cure rate was 92.8% for the children with mixed stenosis, followed by 63.6% in children with glottis stenosis and 55.6% in children with subglottic stenosis. Free hyoid bone reconstruction of the cricoid cartilage for the management of LTS is feasible, with good outcomes and few complications.
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http://dx.doi.org/10.1016/j.ijporl.2022.111227DOI Listing
July 2022

Influence of improved behavioral inhibition on decreased cue-induced craving in heroin use disorder: A preliminary intermittent theta burst stimulation study.

J Psychiatr Res 2022 Aug 13;152:375-383. Epub 2022 Jun 13.

Lanzhou Hospital of Addiction Rehabilitation, Lanzhou, Gansu, China.

Background: Impaired behavioral inhibition is a critical factor in drug addiction and relapse. Repetitive transcranial magnetic stimulation (rTMS) reduces the craving of heroin-addicted individuals for drug-related cues. However, it is unclear whether this technique also improves impaired behavioral inhibition and how improved behavioral inhibition affects craving.

Objective: The intermittent theta-burst stimulation (iTBS) has been recently shown to be non-inferior relative to rTMS for depression. Here, we aim to investigate the effect of iTBS on heroin-addicted individuals' behavioral inhibition and cue-induced craving and the relationship between the alteration of behavioral inhibition and craving.

Method: 42 of 56 initially recruited individuals with the heroin-use disorder in the abstinent-course treatment were randomized to undergo active or sham iTBS to the left dorsolateral prefrontal cortex and received three daily iTBS treatments for 10 consecutive days. We measured participants' performance during a two-choice oddball task (80% standard and 20% deviant trials) and heroin-related cue-induced craving before and immediately after treatment.

Results: The group that received active iTBS showed significantly improved two-choice oddball task performance after 10 days of intervention compared to both pre-intervention and the group who received sham iTBS. Similarly, a significant reduction in cue-induced craving was observed after following the intervention in the active iTBS group but not the sham iTBS group. The moderation model indicated that iTBS categories play a significant moderating role in the relationship between accuracy cost changing and altered cue-induced craving.

Conclusions: The iTBS treatment protocol positively affects behavioral inhibition in patients with heroin addiction. Improvements in behavioral inhibition can substantially reduce craving.
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http://dx.doi.org/10.1016/j.jpsychires.2022.06.010DOI Listing
August 2022

Determining the interlayer shearing in twisted bilayer MoS by nanoindentation.

Nat Commun 2022 Jul 6;13(1):3898. Epub 2022 Jul 6.

State Key Laboratory of New Ceramics and Fine Processing & Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.

The rise of twistronics has increased the attention of the community to the twist-angle-dependent properties of two-dimensional van der Waals integrated architectures. Clarification of the relationship between twist angles and interlayer mechanical interactions is important in benefiting the design of two-dimensional twisted structures. However, current mechanical methods have critical limitations in quantitatively probing the twist-angle dependence of two-dimensional interlayer interactions in monolayer limits. Here we report a nanoindentation-based technique and a shearing-boundary model to determine the interlayer mechanical interactions of twisted bilayer MoS. Both in-plane elastic moduli and interlayer shear stress are found to be independent of the twist angle, which is attributed to the long-range interaction of intermolecular van der Waals forces that homogenously spread over the interfaces of MoS. Our work provides a universal approach to determining the interlayer shear stress and deepens the understanding of twist-angle-dependent behaviours of two-dimensional layered materials.
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http://dx.doi.org/10.1038/s41467-022-31685-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259563PMC
July 2022

N7-Methylguanosine Regulatory Genes Profoundly Affect the Prognosis, Progression, and Antitumor Immune Response of Hepatocellular Carcinoma.

Front Surg 2022 16;9:893977. Epub 2022 Jun 16.

ChongQing Medical University, Chongqing, China.

Background: Hepatocellular carcinoma (HCC) is a common abdominal cancer with poor survival outcomes. Although there is growing evidence that N7-methylguanosine (m7G) is closely associated with tumor prognosis, development, and immune response, few studies focus on this topic.

Methods: The novel m7G risk signature was constructed through the Lasso regression analysis. Its prognostic value was evaluated through a series of survival analyses and was tested in ICGC-LIRI, GSE14520, and GSE116174 cohorts. CIBERSORT, ssGSEA, and ESTIMATE methods were applied to explore the effects of the m7G risk score on tumor immune microenvironment (TIM). The GSEA method was used to evaluate the impacts of the m7G risk score on glycolysis, ferroptosis, and pyroptosis. The human protein atlas (HPA) database was used to clarify the histological expression levels of five m7G signature genes. The biofunctions of NCBP2 in hepatocellular cancer (HC) cells were confirmed through qPCR, CCK8, and transwell assays.

Results: Five m7G regulatory genes comprised the novel risk signature. The m7G risk score was identified as an independent prognostic factor of HCC and could increase the decision-making benefit of traditional prognostic models. Besides, we established a nomogram containing the clinical stage and m7G risk score to predict the survival rates of HCC patients. The prognostic value of the m7G model was successfully validated in ICGC and GSE116174 cohorts. Moreover, high m7G risk led to a decreased infiltration level of CD8+ T cells, whereas it increased the infiltration levels of Tregs and macrophages. The glycolysis and pyroptosis processes were found to be enriched in the HCC patients with high m7G risk. Finally, overexpression of NCBP2 could promote the proliferation, migration, and invasion of HC cells.

Conclusions: The m7G risk score was closely related to the prognosis, antitumor immune process, glycolysis, and malignant progression of HCC. NCBP2 has pro-oncogenic abilities, showing promise as a novel treatment target.
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http://dx.doi.org/10.3389/fsurg.2022.893977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246272PMC
June 2022

Does Dysmenorrhea Affect Clinical Features and Long-Term Surgical Outcomes of Patients With Ovarian Endometriosis? A 12-Year Retrospective Observational Cohort Study.

Front Med (Lausanne) 2022 16;9:905688. Epub 2022 Jun 16.

National Clinical Research Center for Obstetrics and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background: To examine and compare the differences in clinical characteristics and long-term postoperative outcomes of ovarian endometriomas (OMA) patients with and without dysmenorrhea, including data from at least 8 years of postoperative follow-up examinations.

Methods: Retrospective analysis of 334 OMA patients, including their demographic and clinical data. Long-term follow-up record was also collected. All laparoscopic cystectomy procedures were performed by the same surgeon at Peking Union Medical College Hospital between January 2009 and April 2013. Patients were divided into the dysmenorrhea and non-dysmenorrhea groups to perform the analysis of their preoperative characteristics, relevant surgical findings, and postoperative outcomes at the follow-up.

Results: Out of 334 OMA patients, 257 (76.9%) patients were allocated to the dysmenorrhea group, while the rest 77 (23.1%) patients were included in the non-dysmenorrhea group. Compared with the dysmenorrhea group, the non-dysmenorrhea group exhibited a reduced proportion of chronic pelvic pain (CPP) ( = 0.003), dyspareunia ( < 0.001), tenesmus ( < 0.001), concurrency of deep infiltrating endometriosis (DIE) ( < 0.001), and adenomyosis ( = 0.032). Preoperative infertility was significantly higher in the dysmenorrhea group ( = 0.001). The mean operating time in the dysmenorrhea vs. the non-dysmenorrhea group was 68.0 vs. 56.0 min ( < 0.001). According to the revised American Fertility Society (rAFS) scoring system, the mean scores of the two groups were 52.1 vs. 44.6 ( = 0.033). During follow-up, the dysmenorrhea group showed a higher rate of disease relapse ( < 0.001). A minimum postoperative follow-up period of 8 years was required to evaluate the pregnancy outcomes. Successful pregnancies were identified in 97/257 (37.7%) cases in the dysmenorrhea group and 36/77(46.8%) cases in the non-dysmenorrhea group ( = 0.157), respectively. Though the dysmenorrhea group had a higher rate of postoperative infertility, differences were not significant between the two groups.

Conclusions: Compared with the dysmenorrhea group, OMA patients without dysmenorrhea exhibited lower proportions of CPP, dyspareunia, tenesmus, lower concurrency of DIE and adenomyosis, shorter mean operating time, lower mean rAFS scores, and lower infertility rates. During the long-term follow-up, a lower recurrence rate was observed in the non-dysmenorrhea group. Regarding fertility outcomes, non-dysmenorrhea patients had a higher likelihood of successful pregnancy after surgery. Postoperative management needs to be evaluated separately according to dysmenorrhea pathology.
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http://dx.doi.org/10.3389/fmed.2022.905688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243552PMC
June 2022

dbBIP: a comprehensive bipolar disorder database for genetic research.

Database (Oxford) 2022 07;2022

Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education and Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, 111 Jiulong Road, Shushan District, Hefei, Anhui 230601, China.

Bipolar disorder (BIP) is one of the most common hereditary psychiatric disorders worldwide. Elucidating the genetic basis of BIP will play a pivotal role in mechanistic delineation. Genome-wide association studies (GWAS) have successfully reported multiple susceptibility loci conferring BIP risk, thus providing insight into the effects of its underlying pathobiology. However, difficulties remain in the extrication of important and biologically relevant data from genetic discoveries related to psychiatric disorders such as BIP. There is an urgent need for an integrated and comprehensive online database with unified access to genetic and multi-omics data for in-depth data mining. Here, we developed the dbBIP, a database for BIP genetic research based on published data. The dbBIP consists of several modules, i.e.: (i) single nucleotide polymorphism (SNP) module, containing large-scale GWAS genetic summary statistics and functional annotation information relevant to risk variants; (ii) gene module, containing BIP-related candidate risk genes from various sources and (iii) analysis module, providing a simple and user-friendly interface to analyze one's own data. We also conducted extensive analyses, including functional SNP annotation, integration (including summary-data-based Mendelian randomization and transcriptome-wide association studies), co-expression, gene expression, tissue expression, protein-protein interaction and brain expression quantitative trait loci analyses, thus shedding light on the genetic causes of BIP. Finally, we developed a graphical browser with powerful search tools to facilitate data navigation and access. The dbBIP provides a comprehensive resource for BIP genetic research as well as an integrated analysis platform for researchers and can be accessed online at http://dbbip.xialab.info. Database URL:  http://dbbip.xialab.info.
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http://dx.doi.org/10.1093/database/baac049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250320PMC
July 2022

[Retracted] MicroRNA‑760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1‑mediated PTEN/AKT signalling pathway.

Mol Med Rep 2022 Aug 28;26(2). Epub 2022 Jun 28.

Department of General Surgery, Linyi Central Hospital, Linyi, Shandong 276000, P.R. China.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell migration and invasion assay data shown in Figs. 2C and 5C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to , the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused. [the original article was published in Molecular Medicine Reports 16: 9692‑9700, 2017; DOI: 10.3892/mmr.2017.7814].
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http://dx.doi.org/10.3892/mmr.2022.12783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260877PMC
August 2022

Effect of Different Glucose Monitoring Methods on Bold Glucose Control: A Systematic Review and Meta-Analysis.

Comput Math Methods Med 2022 18;2022:2851572. Epub 2022 Jun 18.

Department of Endocrine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China.

Objective: To evaluate the effectiveness of different glucose monitoring methods on blood glucose control and the incidence of adverse events among patients with type 1 diabetes mellitus.

Methods: Using the method of literature review, the databases PubMed, Cochrane, and Embase were retrieved to obtain relevant research literature, and the selected studies were analyzed and evaluated. This study used Cochrane software RevMan5.4 to statistically analyze all the data.

Results: A total of 15 studies were included in this study, including 10 randomized controlled trials and 5 crossover design trials, with a total of 2071 patients. Meta-analysis results showed that continuous blood glucose monitoring (CGM) could significantly reduce the HbA1c level of patients, weighted mean difference (WMD) = -2.69, 95% confidence interval (CI) (-4.25, -1.14), and < 0.001 compared with self-monitoring of blood glucose (SMBG). Meanwhile, the incidence of severe hypoglycemia in the CGM group was significantly decreased, risk ratio (RR) = 0.52, 95% CI 0.35-0.77, and = 0.001. However, there was no statistical difference in the probability of diabetic ketoacidosis between CGM and SMBG groups, RR = 1.34, 95% CI 0.57-3.15, and = 0.5.

Conclusion: Continuous blood glucose monitoring is associated with lower blood glucose levels than the traditional blood glucose self-test method.
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http://dx.doi.org/10.1155/2022/2851572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233597PMC
June 2022

The Development of Predictive Nomogram of Recurrence for Patients With Endometrioma After Cystectomy Who Were Younger Than 45 Years Old and Received Postoperative Therapy.

Front Med (Lausanne) 2022 9;9:872481. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: This study aimed to establish an effective prognostic nomogram for the postoperative recurrence of endometrioma or endometriosis-related pain for patients with endometrioma after long-term follow-up, who were younger than 45 years old and received postoperative therapy.

Methods: The predictive nomogram was based on 323 patients who underwent cystectomy for endometrioma at Perking Union Medical College Hospital from January 2009 to April 2013, and the last follow-up occurred in September 2018. We collected information on all included patients, including preoperative data, intraoperative data, and long-term follow-up data after surgery. The Cox proportional hazards regression model was used to evaluate the prognostic effects of multiple clinical parameters on recurrence. The survival curve was depicted based on Kaplan-Meier method and compared by log-rank method. The Index of concordance (C-index) and calibration curves were used to access the discrimination ability and predictive accuracy of the nomogram respectively, and the results were further validated via bootstrap resampling. In addition, calculating the area under the curve (AUC) via risk scores of patients aimed to further access the prediction ability of the model.

Results: On multivariate analysis of derivation cohort, independent factors for recurrence such as dysmenorrhea degree, sum of both cyst diameters, presence of adenomyosis, and other essential factors for recurrence such as age at surgery, presence of uterine fibroids were all selected into the nomogram. The C-index of the nomogram for predicting recurrence was 0.683 (95% CI, 0.610- 0.755). The calibration curve for probability of recurrence for 7 years and 9 years showed great agreement between prediction by nomogram and actual observation. Furthermore, the AUCs of risk score for 7-year and 9-year were 0.680 and 0.790 respectively.

Conclusion: This research tried to develop the predictive nomogram of recurrence for patients with endometrioma after cystectomy. The C-index and calibration curve of nomogram, as well as the AUC of the nomogram was potential to predict the recurrence probability. In addition, this predictive nomogram needs external data sets to further validate its prognostic accuracy in the future.
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http://dx.doi.org/10.3389/fmed.2022.872481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218256PMC
June 2022

Improved control scheme for simultaneous reduction of common-mode voltage and current harmonic distortion of the Vienna-type rectifier with balanced and unbalanced neutral-point voltages.

ISA Trans 2022 Jun 1. Epub 2022 Jun 1.

School of Control Science and Engineering, Shandong University, Jinan 250061, China. Electronic address:

As a non-generative-boost rectifier, the Vienna-type rectifier has been proposed and applied in several applications, such as wind power generation systems, battery charging system, etc. This paper further proposes an improved control scheme for reducing common-mode voltage (CMV) and input current harmonic distortions under balanced and unbalanced neutral-point (NP) voltages. At first, the operating fundamentals of the Vienna-type rectifier are presented. The zero-sequence voltage and its corresponding ranges are carefully derived to control the dc-link capacitor voltages separately. Considering the specific constraint of this rectifier, the zero-sequence voltage is further revised to reduce the current harmonic distortions around the zero-crossing points. Doing so, the simultaneous reduction of CMV and input current harmonic distortions can be realized, which is applicable to balanced and unbalanced NP voltages. The comparisons of the proposed scheme, the conventional zero-sequence voltage injection scheme, and the CMV reduction method under balanced NP voltage condition are conducted, which demonstrate the salient advantages of the presented scheme.
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http://dx.doi.org/10.1016/j.isatra.2022.05.032DOI Listing
June 2022

Dominant Components of the Giant Panda Seminal Plasma Metabolome, Characterized by H-NMR Spectroscopy.

Animals (Basel) 2022 Jun 14;12(12). Epub 2022 Jun 14.

Department of Agricultural and Food Sciences, University of Bologna, 47521 Cesena, Italy.

As an assisted breeding technique, artificial insemination has become the main effective practical approach in the captive breeding programs of giant panda worldwide. The composition of seminal plasma plays an important role in the success of breeding. The present work is the first attempt to characterize, by proton magnetic resonance spectroscopy (H-NMR), the metabolome of healthy giant panda seminal plasma. A total of 35 molecules were quantified, with the concentration of 2,3-butanediol being significantly different between individuals younger than 8 years and older than 13 years, and other distinct age-related trends were highlighted by a multivariate analysis. Isopropanol's concentration was significantly linked to estrus stages. Besides, the variations in the metabolome's profile during storage were also evaluated. This study may serve as a reference for further research wishing to shed light on the biological mechanisms affecting giant panda sperm's overall quality and may ultimately lead to novel approaches to giant panda artificial insemination.
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http://dx.doi.org/10.3390/ani12121536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219455PMC
June 2022

New insight into human health risk from polycyclic aromatic hydrocarbons on surfaces of buildings and facilities for industrial legacy regeneration.

J Hazard Mater 2022 08 16;436:129158. Epub 2022 May 16.

Environmental Sustainable Development Technology Center, 100102 Beijing, China.

Although many industrial heritage sites have been repurposed into attractive landscapes, the contamination and health risks from polycyclic aromatic hydrocarbons (PAHs) on industrial legacy surfaces remain unexplored. We collected 441wiping surface samples from 95 buildings and facilities at Beijing coking plant in China and found that the concentrations of 16 US EPA priority PAHs (∑PAHs) ranged from ND-982.16 and ND-4262.20 mg/m on the surfaces of buildings and facilities, respectively. The main source of PAHs was the coking process, and spatial distribution of PAHs was consistent with ∑PAHs in the soil. The carcinogenic risks of BaP, DBA, BbF, BaA, Ind of the facilities remained as industrial heritage relics, and those of Bap, DBA and BbF in the buildings with commercial uses exceeded the acceptable level (10). The hazard quotient of 9 PAHs was below the acceptable level (1.0). The remedial goals for BaP and DBA (0.11 mg/m) and BbF, BaA and Ind (1.14 mg/m) at the facility heritage relics were derived. Similarly, the RGs for the buildings with commercial uses of BaP, DBA and BbF were 0.16, 0.16, and 1.64 mg/m, respectively. Overall, we determined that carcinogenic PAHs on the surfaces of industrial legacy should be regulated for regeneration.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129158DOI Listing
August 2022
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