Publications by authors named "Xiaoyan Li"

1,091 Publications

  • Page 1 of 1

Adherence to preventive behaviors among college students during COVID-19 pandemic in China: The role of health beliefs and COVID-19 stressors.

Curr Psychol 2021 Jun 9:1-11. Epub 2021 Jun 9.

Institute of Developmental Psychology, Beijing Normal University, Beijing, People's Republic of China.

Before herd immunity is reached, preventive practices still play an important role in controlling the COVID-19 pandemic. Adherence to preventive behaviors could be determined by individuals' health beliefs, which would be influenced by antecedent factors such as previous exposure to pandemic stressors. Applying the health belief model (HBM), this study aims to examine the mediation association among COVID-19 stressors, HBM constructs, and preventive behaviors. Longitudinal data were collected from 1225 Chinese college students using web-based surveys at wave 1 (w1; between January 31 and February 11, 2020) and wave 2 (w2; between March 20 and April 3, 2020). Participants reported their COVID-19 stressors (w1), five HBM constructs (w2), and preventive behaviors (w1 and w2). Paired t-tests suggested that social distancing and self-quarantine behaviors decreased while precautionary behaviors increased from w1 to w2. Path analysis indicated that two HBM constructs (perceived barriers and self-efficacy) mediated the association between COVID-19 stressors and precautionary behaviors. These findings suggested that tailored prevention intervention for college students should attend to perceived barriers and self-efficacy. Individuals who exposed to multiple pandemic stressors merit particular attention and intervention should account for their early pandemic stress experiences.
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http://dx.doi.org/10.1007/s12144-021-01942-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189278PMC
June 2021

HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway.

Pathol Res Pract 2020 Jul 13;224:153117. Epub 2020 Jul 13.

National Clinical Research Center for Normal Aging and Geriatric & The Key Lab of Normal Aging and Geriatric, Institute of Geriatric, PLA General Hospital, Beijing, China. Electronic address:

Objective: The present study was designed to explore the function of HOXB5 in breast cancer and related signaling pathway.

Methods: Breast cancer tissues and non-cancerous tissues were collected from 82 cases who were pathologically diagnosed with breast cancer. The mRNA level of HOXB5 was detected via quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was adopted to analyze the association of HOXB5 with clinical features. The viability, migration and invasion of breast cancer cells were detected through MTT and Transwell assays, respectively. Protein analysis was performed adopting western blot analysis.

Results: HOXB5 expression was increased in breast cancer tissues and cells, and showed positive correlation with tumor size (P = 0.028), TNM stage (P = 0.048), and lymph node metastasis (P = 0.002). Losing HOXB5 expression suppressed clone formation, proliferation, migration and invasion of breast cancer cells. The knockdown of HOXB5 significantly inactivated wnt/β-catenin pathway. Furthermore, wnt/β-catenin pathway had the potential to neutralize the oncogenic function of HOXB5 in breast cancer.

Conclusion: HOXB5 may be involved in the invasive progression of breast cancer. The function of HOXB5 in breast cancer was mediated by wnt/β-catenin pathway.
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http://dx.doi.org/10.1016/j.prp.2020.153117DOI Listing
July 2020

Surgical pharmacy: the knowledge system of surgical pharmacists.

Eur J Hosp Pharm 2021 Jun 10. Epub 2021 Jun 10.

Department of Pharmacy, The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China.

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http://dx.doi.org/10.1136/ejhpharm-2021-002887DOI Listing
June 2021

CMAP Scan Examination of the First Dorsal Interosseous Muscle after Spinal Cord Injury.

IEEE Trans Neural Syst Rehabil Eng 2021 Jun 9;PP. Epub 2021 Jun 9.

The study assessed motor unit loss in muscles paralyzed by spinal cord injury (SCI) using a novel compound muscle action potential (CMAP) scan examination. The CMAP scan of the first dorsal interosseous (FDI) muscle was applied in tetraplegia (n=13) and neurologically intact (n=13) subjects. MScanFit was used for estimating motor unit numbers in each subject. The D50 value of the CMAP scan was also calculated. We observed a significant decrease in both CMAP amplitude and motor unit number estimation (MUNE) in paralyzed FDI muscles, as compared with neurologically intact muscles. Across all subjects, the CMAP (negative peak) amplitude was 8.01 ± 3.97 mV for the paralyzed muscles and 16.75 ± 3.55 mV for the neurologically intact muscles (p < 0.001). The CMAP scan resulted in a MUNE of 59 ± 37 for the paralyzed muscles, much lower than 108 ± 21 for the neurologically intact muscles (p < 0.001). No significant difference in D50 was observed between the two groups (p = 0.2). For the SCI subjects, there was no significant correlation between MUNE and CMAP amplitude, or any of the clinical assessments including pinch force, grip force, the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) score, and SCI duration (p > 0.05). The findings provide an evidence of motor unit loss in the FDI muscles of individuals with tetraplegia, which may contribute to weakness and other hand function deterioration. The CMAP scan offers several practical benefits compared with the traditional MUNE techniques because it is noninvasive, automated and can be performed within several minutes.
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http://dx.doi.org/10.1109/TNSRE.2021.3088061DOI Listing
June 2021

Endoscopic coblation treatment for congenital pyriform sinus fistula in children.

Medicine (Baltimore) 2021 May;100(19):e25942

Department of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract: Congenital pyriform sinus fistula (CPSF) is a very rare branchial apparatus malformation. Traditional open surgery for fistulectomy might fail to excise the lesion completely, leading to continual recurrence. Herein, we report our experience of endoscopic coblation technique for treatment of CPSF in children.To observe the clinical efficacy of endoscopic coblation treatment of CPSF in children, especially for those in acute infection stage.Retrospective case series with 54 patients (including 20 cases in acute infection stage and 34 cases in non infection stage) who were diagnosed with CPSF between October 2017 to November 2019, all patients were treated with endoscopic coblation to close the piriform fossa fistula, neck abscess incision and drainage performed simultaneously for acute infection stage cases. Data collected including age of diagnosis, presenting symptoms, diagnostic methods, prior and subsequent treatments, length of hospitalization, and recurrence were analyzed.Of the 20 cases in acute infection stage, there were 3 children with transient vocal cord paresis all of which resolved with 1 month. Four children of the 34 cases in non infection stage appeared reddish swelling of the neck on the 4th, 5th, 6th, and 7th days after coblation and then underwent abscess incision and drainage. All cases experienced no recurrence, vocal cord paralysis, pharyngeal fistula and massive hemorrhage after their first endoscopic coblation of the sinus tract in the follow up of 3 to 28 months.Endoscopic coblation is an effective and safe approach for children with CPSF, neck abscess incision and drainage could be performed simultaneously in acute infection stage. We advocate using this minimally invasive technique as first line of treatment for CPSF.
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http://dx.doi.org/10.1097/MD.0000000000025942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133172PMC
May 2021

The complete mitochondrial genome of a burying beetle, Hope, 1831 (Coleoptera: Silphidae).

Mitochondrial DNA B Resour 2021 May 24;6(6):1727-1728. Epub 2021 May 24.

Hebei Key Laboratory of Animal Diversity, Langfang Normal University, Langfang, China.

The complete mitochondrial genome of burying beetle Hope, 1831 was reported in this study. It was 17,299 bps in length and included 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and a 2693 bp A + T-rich control region. Phylogenetic analysis using 13 PCGs from 38 Staphyliniform beetle species revealed that was clustered in Silphidae, which together with Staphylinidae formed one monophyletic clade within Staphylinoidea.
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http://dx.doi.org/10.1080/23802359.2021.1930220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158231PMC
May 2021

Ferrous hemoglobin and hemoglobin-based oxygen carriers acting as a peroxidase can inhibit oxidative damage to endothelial cells caused by hydrogen peroxide.

Artif Organs 2021 Jun 8. Epub 2021 Jun 8.

College of Life Science, Northwest University, Xi'an, P.R. China, 710069.

Oxidative damage caused by the ferryl hemoglobin is one of the major clinical adverse reactions of hemoglobin-based oxygen carriers (HBOCs), while the production of reactive oxygen species in a pathological state can oxidize hemoglobin (HbFe ) to ferryl Hb, which can then enter the pseudoperoxidase cycle, making hemoglobin highly toxic. In this study, we found that ferrous hemoglobin and polymerized porcine hemoglobin (one of the HBOCs) have the peroxidase activity different from the pseudoperoxidase activity of ferric hemoglobin. Ferrous hemoglobin can catalyze the reaction of tyrosine (Tyr) with hydrogen peroxide. In addition, the results also indicated that ferrous hemoglobin and pPolyHb have a strong inhibitory effect on the pseudoperoxidase activity of ferric hemoglobin. Therefore, hydrogen peroxide was consumed in a large amount, which greatly prevented hemoglobin from becoming oxidized and entering the pseudoperoxidase cycle, thus inhibiting ferryl Hb toxicity. We further cultured human umbilical vein endothelial cells and monitored cell morphology, viability, cell cycle, apoptosis, LDH release, and MDA formation when incubated with H O , Tyr, and HbFe . HbFe and pPolyHb reduced cell cycle arrest, apoptosis, LDH release, and MDA formation. These results showed that reducing oxidative damage induced by H O and converted hemoglobin from a molecule that is toxic to one that inhibits oxidative damage, suggesting a new strategy for development of a safer HBOCs.
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http://dx.doi.org/10.1111/aor.14009DOI Listing
June 2021

Circular RNA expression profile in transgenic diabetic mouse kidneys.

Cell Mol Biol Lett 2021 Jun 7;26(1):25. Epub 2021 Jun 7.

Laboratory Medicine Centre, The Affiliated Shunde Hospital of Guangzhou Medical University, Foshan, 528315, China.

Background: Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNAs (circRNAs) play crucial regulatory roles in numerous human diseases and normal physiology; however, to date, no study has focused on the comprehensive expression profile of circRNAs in the kidneys of diabetic mice. Therefore, we aimed to identify differentially expressed circRNAs in diabetic mouse kidneys to explore the possible roles of dysregulated circRNAs in diabetic nephropathy development.

Results: Diabetic BKS-Lepr/Nju (BKS-DB/Nju) mice and their nondiabetic wild-type littermates of C57BL/KsJ wild-type (WT) mice were used as experimental animals. Among all circRNAs identified by high-throughput RNA sequencing, four circRNAs were upregulated and ten were downregulated in diabetic mouse kidneys compared to those in nondiabetic mouse kidneys. After verification using quantitative reverse transcriptase polymerase chain reaction assays, we found that circR_1084, circR_182, circR_4, circR_50, circR_596, circR_897, and circR_203 were downregulated, whereas circR_627, circR_628, circR_735, and circR_801 were upregulated in the renal tissues of 8- and 16-week-old BKS-DB/Nju mice compared to those in WT mice.

Conclusion: We studied the circRNA expression profile in the kidneys of diabetic mice. Differentially expressed circRNAs may be useful as candidate biomarkers for diabetic nephropathy. Collectively, our results provide a novel theoretical basis for further investigation of the regulatory roles of circRNA in the etiology and pathogenesis of diabetic nephropathy.
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http://dx.doi.org/10.1186/s11658-021-00270-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182942PMC
June 2021

A novel identified circ-ANKHD1 targets the miR-27a-3p/SFRP1 signaling pathway and modulates the apoptosis of granulosa cells.

Environ Sci Pollut Res Int 2021 Jun 5. Epub 2021 Jun 5.

National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.

The specific expression profile and function of circular RNAs (circRNAs) in mammalian ovarian follicles, especially during the atresia process, are unclear. In this study, we verified and explored the expression and function of circ-ANKHD1 in granulosa cells. Our results showed that abundance of circ-ANKHD1 was significantly lower in the granulosa cells than that of ANKHD1. The expression of ANKHD1 was highest in the granulosa cells from follicles with a diameter of 5-6 mm and lowest in that with a diameter of 3-4 mm. Furthermore, the expression level of circ-ANKHD1 in the ovarian tissue of 1-day-old piglets was significantly higher than that of 17-month-old multiparous sows. The luciferase reporter assay showed the potential interaction between circ-ANKHD1 and miR-27a-3p/miR-142-5p. Furthermore, circ-ANKHD1 overexpression up-regulated SFRP1 expression, while miR-27a-3p overexpression suppressed SFRP1 expression in granulosa cells. Circ-ANKHD1 overexpression significantly decreased the cell apoptotic rates of the granulosa cells and repressed the cell population at G0/G1 and S phases but increased cell population at G2/M phase. Finally, circ-ANKHD1 overexpression increased the mRNA expression levels of Bcl-2 and cyclin D1 in the granulosa cells, while there are no effects on the mRNA expression levels of caspase-3, p53, Bax, and proliferating cell nuclear antigen. In conclusion, our study for the first time identified a novel circRNA, circ-ANKHD1 that may be associated with the biological functions of granulosa cells. Circ-ANKHD1 may promote the granulosa cell proliferation, but attenuate apoptosis, and these effects may be associated with modulation of miR-27a-3p/SFRP1.
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http://dx.doi.org/10.1007/s11356-021-14699-4DOI Listing
June 2021

Proteomics unravels new candidate genes of Dasypyrum villosum for improving wheat quality.

J Proteomics 2021 Jun 2;245:104292. Epub 2021 Jun 2.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Yangling 712100, China. Electronic address:

Wheat is one of the most widely grown and important food crops in the world, providing approximately 20% of the food energy and protein produced for human consumption. The progress of wheat breeding is seriously restricted by the narrow genetic basis of common wheat germplasms. Dasypyrum villosum, a wild grass species that is commonly used in wheat improvement, has many excellent traits such as disease resistance, drought resistance, cold resistance, strong tillering ability, and processing quality. In this study, we compared and analyzed the cultivated wheat variety Chinese Spring (CS) and D. villosum using comparative proteomics. A total of 883 different abundant proteins (DAPs) were identified. Some of these different abundant proteins are associated with defense and stress, such as the G subunit, zinc finger protein family, PR1, HSP family, LEA protein, and serpin family. And a total of 24 different abundant proteins are gluten proteins. There are also 24 different abundant proteins associated with starch and sucrose metabolism. These results will provide potential candidate genes and a foundation for further research on resistance and quality for wheat genetics and breeding. SIGNIFICANCE: Proteins are the direct functional molecules of living organisms. It is of great significance to study the function of plant related genes from the perspective of protein. In this study, proteomics methods based on iTRAQ were used to compare the proteomic differences between wheat varieties Chinese Spring (CS) and D. villosum. The results provide novel insight into improving the quality of wheat. It is helpful to search for potential candidate genes for improving wheat quality and elucidate the molecular mechanisms associated with these genes.
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http://dx.doi.org/10.1016/j.jprot.2021.104292DOI Listing
June 2021

Intrinsic toughening and stable crack propagation in hexagonal boron nitride.

Nature 2021 Jun 2;594(7861):57-61. Epub 2021 Jun 2.

Department of Materials Science and NanoEngineering, Rice University, Houston, TX, USA.

If a bulk material can withstand a high load without any irreversible damage (such as plastic deformation), it is usually brittle and can fail catastrophically. This trade-off between strength and fracture toughness also extends into two-dimensional materials space. For example, graphene has ultrahigh intrinsic strength (about 130 gigapascals) and elastic modulus (approximately 1.0 terapascal) but is brittle, with low fracture toughness (about 4 megapascals per square-root metre). Hexagonal boron nitride (h-BN) is a dielectric two-dimensional material with high strength (about 100 gigapascals) and elastic modulus (approximately 0.8 terapascals), which are similar to those of graphene. Its fracture behaviour has long been assumed to be similarly brittle, subject to Griffith's law. Contrary to expectation, here we report high fracture toughness of single-crystal monolayer h-BN, with an effective energy release rate up to one order of magnitude higher than both its Griffith energy release rate and that reported for graphene. We observe stable crack propagation in monolayer h-BN, and obtain the corresponding crack resistance curve. Crack deflection and branching occur repeatedly owing to asymmetric edge elastic properties at the crack tip and edge swapping during crack propagation, which intrinsically toughens the material and enables stable crack propagation. Our in situ experimental observations, supported by theoretical analysis, suggest added practical benefits and potential new technological opportunities for monolayer h-BN, such as adding mechanical protection to two-dimensional devices.
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http://dx.doi.org/10.1038/s41586-021-03488-1DOI Listing
June 2021

Ultrahigh specific strength in a magnesium alloy strengthened by spinodal decomposition.

Sci Adv 2021 Jun 2;7(23). Epub 2021 Jun 2.

School of Materials Science and Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

Strengthening of magnesium (Mg) is known to occur through dislocation accumulation, grain refinement, deformation twinning, and texture control or dislocation pinning by solute atoms or nano-sized precipitates. These modes generate yield strengths comparable to other engineering alloys such as certain grades of aluminum but below that of high-strength aluminum and titanium alloys and steels. Here, we report a spinodal strengthened ultralightweight Mg alloy with specific yield strengths surpassing almost every other engineering alloy. We provide compelling morphological, chemical, structural, and thermodynamic evidence for the spinodal decomposition and show that the lattice mismatch at the diffuse transition region between the spinodal zones and matrix is the dominating factor for enhancing yield strength in this class of alloy.
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http://dx.doi.org/10.1126/sciadv.abf3039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172136PMC
June 2021

Study on polysaccharide polyelectrolyte complex and fabrication of alginate/chitosan derivative composite fibers.

Int J Biol Macromol 2021 May 26;184:181-187. Epub 2021 May 26.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Sodium alginate (SA) blending with quaternary ammonium chitosan (QAC) polysaccharide polyelectrolyte complex (PEC) system was chosen to research the binary blending of anionic and cationic polyelectrolytes in detail and to fabricate SA/QAC composite fibers. The potential charge and the rheology of the PEC solution were characterized through Zeta Laser Particle Size Analyzer and DV-C Rotary Rheometer, the structure and properties of the composite fiber were examined by FT-IR, XRD, SEM, EDS, and YG004 single fiber strength meter. The results showed that as the mass ratio of SA to QAC increased from 0/1 to 10/1, the state of the binary solution in water changed from transparent uniform solution to turbid solution with flocculent precipitate, then back to uniform solution, accompanied by the electrical potential change. Moreover, the electrical potential also depended on salt in solution. By using this uniform PEC solution with the mass ratio of SA to QAC 10/1 and concentration 5.5 wt% in water, SA/QAC composite fibers with excellent performances of breaking strength 2.37 cN·dtex and breaking elongation 14.11%, good antibacterial and hydrophobic properties were fabricated via green wet-spinning process. The FT-IR and EDS determination indicated there formed egg-box between SA and Ca, cross-linked network between glutaraldehyde(GA) and SA, QAC, respectively. Depending on its mechanical, natural, and antibacterial properties, the SA/QAC composite fiber has advantages in wound dressing, medical gauze, medical absorbable suture, and tissue engineering.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.05.150DOI Listing
May 2021

Prevalence and intervention of preoperative anemia in Chinese adults: A retrospective cross-sectional study based on national preoperative anemia database.

EClinicalMedicine 2021 Jun 23;36:100894. Epub 2021 May 23.

Institute of Statistics and Information, Beijing Center for Diseases Control and Prevention, Beijing, China.

Background: Preoperative anemia is an important pillar of perioperative patient blood management. However, there was no literature comprehensively described the current situation of preoperative anemia in China.

Methods: We conducted a national retrospective cross-sectional study to assess the prevalence and intervention of preoperative anemia in Chinese adults. Data were from the National Preoperative Anemia Database based on hospital administration data from January 1, 2013 to December 31, 2018.

Findings: A total of 797,002 patients were included for analysis. Overall, 27.57% (95% CI 27.47-27.67) of patients had preoperative anemia, which varied by gender, age, regions, and type of operation. Patients who were female, age over 60 years old, from South China, from provinces with lower per capita GDP, underwent operations on the lymphatic and hematopoietic system, with laboratory abnormalities were more likely to have a high risk of preoperative anemia. Among patients with preoperative anemia, 5.16% (95% CI 5.07-5.26) received red blood cell transfusion, 7.79% (95% CI 7.67-7.91) received anemia-related medications such as iron, erythropoietin, folic acid or vitamin B12, and 12.25% (95% CI 12.10-12.40) received anemia-related therapy (red blood cell transfusion or anemia-related medications) before operation. The probability of preoperative RBC transfusion decreased by 54.92% (OR 0.46, 95% CI 0.46-0.47) as each 10-g/L increase in preoperative hemoglobin. Patients with preoperative hemoglobin less than 130 g/L was associated with longer hospital stay and more hospital costs. Patients with severe preoperative anemia given iron preoperatively had lower intra/post-operative RBC transfusion rate, shorter length of stay and less hospitalization costs, but no similar correlation was found in patients with mild and moderate preoperative anemia and patients given erythropoietin preoperatively.

Interpretation: Our present study shows that preoperative anemia is currently a relatively prevalent problem that has not been fully appreciated in China. More researches will be required to optimize the treatment of preoperative anemia.

Funding: National Natural Science Foundation of China and the Logistics Support Department of the Central Military Commission.
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http://dx.doi.org/10.1016/j.eclinm.2021.100894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144738PMC
June 2021

Effect of open versus closed endotracheal suctioning on intracranial pressure in severe brain-injured children: Study protocol for a randomized controlled trial.

Nurs Open 2021 May 26. Epub 2021 May 26.

SICU, Children's Hospital of Nanjing Medical University, Nanjing City, China.

Aim: To compare the effects and safety of open and closed endotracheal suction in children with severe brain injury.

Design: A single-blinding, single-centre randomized controlled trial (RCT).

Methods: The children with severe brain injury admitted to the intensive care unit (ICU) from 1 September 2020-31 August 2022 will be included. And a total of 172 children with severe brain injury are expected to be included. The intracranial pressure, SpO and heart rate before suctioning, at the end of suction, and at 5 and 10 min after suction, the estimated sputum volume for each suction, the incidence of ventilator-associated pneumonia, the duration of mechanical ventilation and the length of ICU stay will be analysed.

Results: This present RCT has been prospectively registered in China Clinical Trial Registry (http://www.chictr.org.cn, ChiCTR2000030963). This present study is expected to provide reliable evidence to the airway management in children with severe brain injury.
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http://dx.doi.org/10.1002/nop2.656DOI Listing
May 2021

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression.

Transl Psychiatry 2021 May 21;11(1):306. Epub 2021 May 21.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650204, Kunming, Yunnan, China.

Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and complexity of linkage disequilibrium (LD), the biological mechanisms by which the risk variants exert their effects on depression remain largely unknown. Here, we perform a transcriptome-wide association study (TWAS) of depression by integrating GWAS summary statistics from 807,553 individuals (246,363 depression cases and 561,190 controls) and summary-level gene-expression data (from the dorsolateral prefrontal cortex (DLPFC) of 1003 individuals). We identified 53 transcriptome-wide significant (TWS) risk genes for depression, of which 23 genes were not implicated in risk loci of the original GWAS. Seven out of 53 risk genes (B3GALTL, FADS1, TCTEX1D1, XPNPEP3, ZMAT2, ZNF501 and ZNF502) showed TWS associations with depression in two independent brain expression quantitative loci (eQTL) datasets, suggesting that these genes may represent promising candidates. We further conducted conditional analyses and identified the potential risk genes that driven the TWAS association signal in each locus. Finally, pathway enrichment analysis revealed biologically pathways relevant to depression. Our study identified new depression risk genes whose expression dysregulation may play a role in depression. More importantly, we translated the GWAS associations into risk genes and relevant pathways. Further mechanistic study and functional characterization of the TWS depression risk genes will facilitate the diagnostics and therapeutics for depression.
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http://dx.doi.org/10.1038/s41398-021-01411-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140098PMC
May 2021

New species of the genus Casey, 1905 (Coleoptera, Staphylinidae, Paederinae) from the Northwestern District of China.

Zookeys 2021 5;1036:39-45. Epub 2021 May 5.

Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Rd., Chaoyang District, Beijing 100101, China Guizhou University of Traditional Chinese Medicine Guiyang China.

Two new species of the genus Casey, 1905 from mainland China are reported in this paper, namely Li & Zhou, and Li & Zhou, This genus is reported for the first time from Gansu Province, Northwest China. Both species are described in detail and supplemented with color plates of normal light photos of the habitus, sternites VII-IX and details of aedeagal structures in different views.
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http://dx.doi.org/10.3897/zookeys.1036.60319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116324PMC
May 2021

Assessing redistribution of muscle innervation zones after spinal cord injuries.

J Electromyogr Kinesiol 2021 May 3;59:102550. Epub 2021 May 3.

Institute of Rehabilitation Engineering, University of Rehabilitation, Qingdao, China; Guangdong Work Injury Rehabilitation Center, Guangzhou, China. Electronic address:

This study aimed to examine the redistribution of neuromuscular junctions or innervation zones (IZs) after spinal cord injuries (SCI). Fifteen able-bodied subjects and 15 subjects with SCI (American Spinal Injury Association Impairment Scale A to D), participated in the study. Surface electromyography (EMG) signals were collected from the biceps brachii muscle by a customized linear electrode array when subjects generated maximal isometric voluntary contractions. The Radon transform was applied to detect the IZ locations in the multiple channel surface EMG signals which were differentiated between consecutive channels. The distribution of IZs was compared between the SCI and control groups using the student-t test. Statistical analysis disclosed a significantly wider range of IZs in the SCI group compared with the control group (SCI: 3.83 ± 1.32 IED, control: 2.83 ± 0. 87 IED, IED: inter-electrode distance, p < 0.05). No remarkable shifts of the center of the distribution were observed between the two groups (SCI: 9.23 ± 2.35 IED, control: 8.53 ± 2.33 IED, p = 0.42). Changes of IZ distribution in the paralyzed muscles could be associated with the complex neuromuscular reorganization after the SCI.
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http://dx.doi.org/10.1016/j.jelekin.2021.102550DOI Listing
May 2021

Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer.

J Gastrointest Oncol 2021 Apr;12(2):388-406

Department of Pharmacy, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family refers to a family of transcriptional repressor genes. CMTMs are closely associated with the epigenetic regulatory mechanisms and development of multiple malignancies, including gastric cancer. However, their specific biological functions and prognostic values in gastric cancer have yet to be elucidated.

Methods: Tumor sample datasets were retrieved and analyzed using databases including Oncomine, STRING, GEPIA2, cBioportal, and Kaplan-Meier plotter. To investigate the prognostic role of CMTMs in gastric cancer, we applied unsupervised hierarchical clustering analysis of CMTM gene expression patterns.

Results: While the mRNA levels of CMTM1/3/6/7/8 were upregulated in gastric cancer, CMTM2/4/5 showed no statistically significant difference at the mRNA level in patients with gastric cancer. Moreover, the mRNA expressions of different CMTMs exhibited strong correlations with various clinical parameters of patients with gastric cancer, including tumor stage, metastatic lymph node status, status, and tumor grade. Also, the results suggested that elevated levels of CMTM3/5 mRNA had a significant association (P<0.05) with poor overall survival, progression-free survival, and post-progression survival. Conversely, elevated expression of CMTM2/4/6 mRNA had a significant association with better overall survival, progression-free survival, and post-progression survival. Unsupervised hierarchical clustering analysis successfully identified 2 major clusters of patients as follows: signature #1: CMTM4/6/8 and signature #2: CMTM1/2/3/5/7. Signature #2 was closely correlated with poorer overall survival, which indicated that the expression pattern of the CMTM family could be a novel prognostic factor for patients with gastric cancer.

Conclusions: These results suggest that the expression levels of CMTM genes possibly have prognostic value as a biomarker of gastric cancer.
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http://dx.doi.org/10.21037/jgo-21-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107618PMC
April 2021

Pregnancy outcomes in women with infertility and coexisting endometriosis and adenomyosis after laparoscopic surgery: a long-term retrospective follow-up study.

BMC Pregnancy Childbirth 2021 May 18;21(1):383. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, P. R. China.

Background: Adenomyosis (AM) and endometriosis (EM) often coexist. Laparoscopic surgery is one of the main methods for diagnosing and treating these conditions. This study aims to investigate the pregnancy outcomes of women with infertility with both AM and EM after laparoscopic surgery and to identify the relevant associated factors.

Methods: This is a retrospective study involving women with infertility diagnosed with EM and AM. All patients had undergone laparoscopic surgery and were divided into two groups according to their pregnancy outcomes. Demographic data, operation records, and pregnancy outcomes were collected.

Results: A total of 226 female patients with infertility diagnosed with both AM and EM underwent laparoscopic surgery. Of these, a total of 176 patients completed follow-up. Ninety-seven patients had live births, including 81 full-term and 16 preterm deliveries. The clinical pregnancy and live birth rates were 67.4 and 55.11%, respectively. One hundred thirty-five patients received in vitro fertilization (IVF), with 70 (51.85%) of these patients having live births. Age, endometrioma size, and uterus size were significantly lower in those who had a successful delivery. There was no statistically significant difference in symptoms, except that those who achieved live birth had a lower rate of anaemia (13.40% vs. 25.32%, p = 0.044). The group that did not proceed to have a live birth had a higher percentage of ovarian and peritoneal endometriosis (p < 0.05), while the distribution of deep infiltrating endometriosis and adenomyosis types were similar. Mean uterus diameter (OR: 0.636, 95% CI: 0.434-0.932, p = 0.020) and endometriosis fertility index (EFI) (OR: 1.299, 95% CI: 1.101-1.531, p = 0.002) were significantly correlated with live birth in the multivariable analysis.

Conclusions: Endometriosis and adenomyosis appear to have an adverse effect on pregnancy outcome. These might be related to the size of the uterus and EFI. Obstetricians and gynaecologists should be alert to this potential adverse effect and manage these patients accordingly.
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http://dx.doi.org/10.1186/s12884-021-03851-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132406PMC
May 2021

Tunable and polarization-sensitive perfect absorber with a phase-gradient heterojunction metasurface in the mid-infrared.

Opt Express 2021 Apr;29(9):12893-12902

Inspired by the growing family of Van der Waals materials, hBN supported phonon polaritons have attracted much attention due to their inherent hyperbolic dispersion properties in the mid-infrared. However, the lack of tunability imposes a severe restriction on the diversified, functional and integrated applications. Here, we propose a phase-gradient heterostructure metasurface to realize a dynamically tunable and polarization-sensitive perfect absorber in the mid-infrared through combining hBN and phase change VO. Narrow-band perfect absorption at 7.2 µm can be switched to broadband around 11.2 µm through controlling the temperature of VO. The governed physics of the bandwidth and absorption differences are demonstrated. Phonon polaritons in hBN phase-gradient configurations and plasmon polaritons in periodic VO blocks are respectively excited. We also investigate the absorption dependence on the polarization states of designed absorber. The method of engineering the absorption through controlling the temperature and polarization states opens up a new avenue for tunable applications such as data storage and integrated optical circuits.
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http://dx.doi.org/10.1364/OE.422519DOI Listing
April 2021

Progress in the preparation and characterization of silylene iron, cobalt and nickel complexes.

Dalton Trans 2021 May;50(20):6766-6772

School of Chemistry and Chemical Engineering, Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, Shandong University, Shanda Nanlu 27, Jinan 250100, China.

The synthesis and characterization of Fe, Co and Ni complexes supported by silylene ligands in the past ten years are summarized. Due to the decrease of the electron cloud density on the Si atom after coordination, the downfield shift of the 29Si chemical shift is accompanied by the coordination between the free silylene ligand and metal. The strong electron-donating ability of silylene makes the metal center more electron-rich, which is conducive to the oxidative addition reaction in the metal center. In some cases, the coordination ability of silylene is stronger than those of phosphine and carbene ligands. Therefore, silylene transition metal complexes have better catalytic activity. The further challenges in this field are to develop new polydentate silylene ligands, synthesize chelate silylene-phosphine and silylene-carbene ligands, and design new silylene transition metal complexes for more catalytic research.
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http://dx.doi.org/10.1039/d1dt00523eDOI Listing
May 2021

Astragaloside IV Inhibits Galactose-Deficient IgA1 Secretion miR-98-5p in Pediatric IgA Nephropathy.

Front Pharmacol 2021 16;12:658236. Epub 2021 Apr 16.

Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.

The factor associated with IgA nephropathy (IgAN) is an abnormality of IgA known as galactose-deficient IgA1 (Gd-IgA1). The purpose of this study was to determine the molecular role played by miRNAs in the formation of Gd-IgA1 in IgAN and investigate the regulatory role of Astragaloside IV (AS-IV) in miRNAs. Bioinformatics analysis, along with functional and mechanistic experiments, were used to investigate the relationship and function of miRNA, β-1, 3-galactosyltransferase (C1GALT1), Gd-IgA1, and AS-IV. Analyses involved a series of tools, including quantitative real-time polymerase chain reaction (qRT-qPCR), Western blot, enzyme-linked immunosorbent assay (ELISA), Vicia Villosa lectin-binding assay (VVA), Cell counting kit-8 assay (CCK-8), and the dual-luciferase reporter assay. miRNA screening and validation showed that miR-98-5p was significantly upregulated in the peripheral blood mononuclear cells (PBMCs) of pediatric patients with IgAN compared with patients diagnosed with mesangial proliferative glomerulonephritis (MsPGN) and immunoglobulin A vasculitis nephritis (IgAV-N), and healthy controls ( < 0.05). Experiments with the dual-luciferase reporter confirmed that miR-98-5p might target C1GALT1. The overexpression of miR-98-5p in DAKIKI cells decreased both the mRNA and protein levels of C1GALT1 and increased the levels of Gd-IgA1 levels; these effects were reversed by co-transfection with the C1GALT1 plasmid, and . In addition, AS-IV downregulated the levels of Gd-IgA1 level in DAKIKI cells by inhibiting miR-98-5p. Our results revealed that AS-IV could inhibit Gd-IgA1 secretion miR-98-5p. Increased levels of miR-98-5p in pediatric IgAN patients might affect the glycosylation of IgA1 by targeting C1GALT1. In addition, our analyses suggest that the pathogenesis of IgAN may differ from that of IgAV-N. Collectively, these results provide significant insight into the pathogenesis of IgAN and identify a potential therapeutic target.
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http://dx.doi.org/10.3389/fphar.2021.658236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085534PMC
April 2021

A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression.

Mol Psychiatry 2021 Apr 30. Epub 2021 Apr 30.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Genome-wide association studies (GWASs) have revealed that genetic variants at the 22q13.2 risk locus were robustly associated with schizophrenia. However, the causal variants at this risk locus and their roles in schizophrenia remain elusive. Here we identify the risk missense variant rs1801311 (located in the 1st exon of NDUFA6 gene) as likely causal for schizophrenia at 22q13.2 by disrupting binding of YY1, TAF1, and POLR2A. We systematically elucidated the regulatory mechanisms of rs1801311 and validated the regulatory effect of this missense variant. Intriguingly, rs1801311 physically interacted with NAGA (encodes the alpha-N-acetylgalactosaminidase, which is mainly involved in regulating metabolisms of glycoproteins and glycolipids in lysosome) and showed the most significant association with NAGA expression in the human brain, with the risk allele (G) associated with higher NAGA expression. Consistent with eQTL analysis, expression analysis showed that NAGA was significantly upregulated in brains of schizophrenia cases compared with controls, further supporting that rs1801311 may confer schizophrenia risk by regulating NAGA expression. Of note, we found that NAGA regulates important neurodevelopmental processes, including proliferation and differentiation of neural stem cells. Transcriptome analysis corroborated that NAGA regulates pathways associated with neuronal differentiation. Finally, we independently confirmed the association between rs1801311 and schizophrenia in a large Chinese cohort. Our study elucidates the regulatory mechanisms of the missense schizophrenia risk variant rs1801311 and provides mechanistic links between risk variant and schizophrenia etiology. In addition, this study also revealed the novel role of coding variants in gene regulation and schizophrenia risk, i.e., genetic variant in coding region of a specific gene may confer disease risk through regulating distal genes (act as regulatory variant for distal genes).
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http://dx.doi.org/10.1038/s41380-021-01125-xDOI Listing
April 2021

Exploring the influence mechanism of ozonation on protein fouling of ultrafiltration membranes as a result of the interfacial interaction of foulants at the membrane surface.

Sci Total Environ 2021 Sep 26;785:147340. Epub 2021 Apr 26.

Research Institute of Membrane Separation Technology of Shaanxi Province, Key Laboratory of Membrane Separation of Shaanxi Province, Key Laboratory of Northwest Water Resources, Key Laboratory of Environmental Engineering of Shaanxi Province, Xi'an University of Architecture and Technology, Yan Ta Road. No. 13, Xi'an 710055, China; School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Yan Ta Road. No. 13, Xi'an 710055, China.

Ozonation was widely used before ultrafiltration processes, but its effect mechanism on protein fouling is still controversial. Ozonation of bovine serum albumin (BSA) solutions was performed in the present work. The interfacial forces of BSA at the membrane surface were measured before and after ozonation. The adsorption behaviour of BSA onto the membrane surface and the fouling layer structures under different ozone dosages were also investigated. These results were combined with the membrane fouling behaviour to identify the effect of ozonation on protein fouling. The results showed that ozonation could weaken the interaction forces between the membrane and BSA effectively, but this did not have any effect on membrane fouling. In contrast, in terms of membrane fouling behaviour after pre-ozonation, the contribution of the changes in the covalent disulfide bonds between BSA molecules outweighs those of the non-covalent bonds. The number of disulfide bonds gradually increased as the O:DOC ratio increased from 0 to 0.3, and began to decline when the O:DOC ratio was further increased to 0.45 and 0.6. This could have altered the deposition rate of foulants onto the membrane surface and the structure of the fouling layers, and may have caused the membrane fouling first to be enhanced and then to decline with increasing ozone dosages.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147340DOI Listing
September 2021

The heterogeneity of fibroblasts in laryngotracheal stenosis and skin hypertrophic scar in pediatric patients.

Int J Pediatr Otorhinolaryngol 2021 Jun 17;145:110709. Epub 2021 Apr 17.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200062, People's Republic of China. Electronic address:

Objectives: To investigate the heterogeneity between the laryngotracheal stenosis and hypertrophic scar derived fibroblasts.

Methods: Human laryngotracheal stenosis (LTS) and skin hypertrophic scar (HTS) specimens were obtained during the tracheal resection and T-shaped tracheal stent implantation surgery. Fibroblasts were isolated and cultured. Cell proliferation and migration were analyzed by cell count, EdU proliferation and wound-healing assays. The expressions of COL1a1, α-SMA, TGF-β1 signaling pathway, chemokines and receptors were analyzed by qRT-PCR, western blotting, and immunohistochemistry.

Results: Cell proliferation and migration of LTS derived fibroblasts were significantly faster than HTS fibroblasts, with no significant difference of the percentage of apoptotic cells. COL1a1, α-SMA, and Integrins were down-regulated in LTS fibroblasts, but TGFB1 and chemokine receptor CXCR7 were up-regulated in LTS fibroblasts. However, the expressions of SMAD4 and phospho-SMAD2/3 were not significantly different.

Conclusions: Human LTS and HTS derived fibroblasts differ in cell proliferation and migration. Different expressions of COL1a1, α-SMA, and CXCR7 were found between the two fibroblasts.
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http://dx.doi.org/10.1016/j.ijporl.2021.110709DOI Listing
June 2021

LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.

PLoS One 2021 28;16(4):e0250772. Epub 2021 Apr 28.

Department of Pulmonary and Critical Care Medicine, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

Background: Single nucleotide polymorphisms (SNPs) in the gene encoding LOXL1 are risk factors for exfoliation syndrome and exfoliation glaucoma. This meta-analysis comprehensively investigated the association between LOXL1 gene polymorphisms (rs1048661, rs3825942, and rs2165241) and the risk of exfoliation syndrome/exfoliation glaucoma (XFS)/(XFG).

Methods: All eligible case-control studies, published before August 17, 2020, were searched on Medline (Ovid), PubMed, CNKI, EMBASE, and Wanfang databases.

Results: In total, 5022 cases and 8962 controls were included in this meta-analysis. Significant associations between LOXL1 gene polymorphisms and XFS/XFG risk was observed in the disease types-based subgroups. In addition, in the subgroup analysis of ethnicity, positive associations between LOXL1 gene polymorphisms (rs1048661, rs3825942, and rs2165241) and XFS/XFG risk were found in Caucasians. Furthermore, rs1048661 and rs3825942 polymorphisms were related to XFS/ XFG risk in Asians; however, no significant association was observed between the LOXL1 gene rs2165241 polymorphism and XFS/XFG risk in Asians. In addition, rs1048661 and rs3825942 correlated with XFS/XFG susceptibility in Africans.

Conclusions: Our results implicate LOXL1 gene polymorphisms as XFS/XFG risk factors, especially in Caucasians.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081202PMC
April 2021

Alterations in Muscle Networks in the Upper Extremity of Chronic Stroke Survivors.

IEEE Trans Neural Syst Rehabil Eng 2021 9;29:1026-1034. Epub 2021 Jun 9.

Muscle networks describe the functional connectivity between muscles quantified through the decomposition of intermuscular coherence (IMC) to identify shared frequencies at which certain muscles are co-modulated by common neural input. Efforts have been devoted to characterizing muscle networks in healthy subjects but stroke-linked alterations to muscle networks remain unexplored. Muscle networks were assessed for eight key upper extremity muscles during isometric force generation in stroke survivors with mild, moderate, and severe impairment and compared against healthy controls to identify stroke-specificalterations in muscle connectivity. Coherence matrices were decomposed using non-negative matrix factorization. The variance accounted for thresholding was then assessed to identify the number of muscle networks. Results showed that the number of muscle networks decreased in stroke survivors compared to age-matched healthy controls (four networks in the healthy control group) as the severity of post-stroke motor impairment increased (three in the mild- and two in the moderate- and severe-strokegroups). Statistically significant reductions of IMC in the synergistic deltoid muscles in the alpha-band in stroke patients versus healthy controls ( p < 0.05) were identified. This study represents the first effort, to the best of our knowledge, to assess stroke-linked alterations in functional intermuscular connectivity using muscle network analysis. The findings revealed a pattern of alterations to muscle networks in stroke survivors compared to healthy controls, as a result of the loss of brain function associated with the stroke. These alterations in muscle networks reflected underlying pathophysiology. These findings can help better understand the motor impairment and motor control in stroke and may advance rehabilitation efforts for stroke by identifying the impaired neuromuscular coordination among multiple muscles in the frequency domain.
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http://dx.doi.org/10.1109/TNSRE.2021.3075907DOI Listing
June 2021

A systematic review and meta-analysis of discharged COVID-19 patients retesting positive for RT-PCR.

EClinicalMedicine 2021 Apr 17;34:100839. Epub 2021 Apr 17.

Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: With the increased number of patients discharged after having COVID-19, more and more studies have reported cases whose retesting was positive (RP) during the convalescent period, which brings a new public health challenge to the world.

Methods: We searched PubMed, Web of Science, The Cochrane Library, CNKI, WanFang and VIP from December 1, 2019 to December 31, 2020. The included studies were assessed using JBI critical appraisal tools and Newcastle-Ottawa Scale. The RP rate of discharge patients was analyzed by a meta-analysis. We adhered to PRISMA reporting guideline.

Findings: We have included 117 studies with 2669 RP participants after discharge. The methodological quality of 66 case reports were low to high, 42 case series and 3 cohort study were moderate to high, 3 case-control studies were moderate and 3 cross-sectional studies were low to moderate. The clinical manifestations of most RP patients were mild or asymptomatic, and CT imaging and laboratory examinations were usually normal. The existing risk factors suggest that more attention should be paid to sever patients, elderly patients, and patients with co-morbidities. The summary RP rate was 12·2% (95% CI 10·6-13·7) with high heterogeneity (  = 85%).

Interpretation: To date, the causes and risk factors of RP result in discharged patients are not fully understood. High-quality etiological and clinical studies are needed to investigate these issues to further help us to make strategies to control and prevent its occurrence.
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http://dx.doi.org/10.1016/j.eclinm.2021.100839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052132PMC
April 2021

Prognostic value of baseline and change in neutrophil-to-lymphocyte ratio for survival in advanced non-small cell lung cancer patients with poor performance status receiving PD-1 inhibitors.

Transl Lung Cancer Res 2021 Mar;10(3):1397-1407

Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.

Background: Advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS) are likely to receive programmed cell death 1 (PD-1) inhibitors, despite limited evidence. The aim of the present study was to report the clinical outcomes and potential prognostic biomarkers in advanced NSCLC patients with poor PS receiving PD-1 inhibitors.

Methods: We conducted a retrospective study enrolling 101 advanced NSCLC patients from our hospital. Data of patients with poor PS 2-4 receiving PD-1 inhibitors were retrieved from medical records. Patients were stratified based on dichotomized baseline neutrophil-to-lymphocyte ratio (NLR), change in NLR (ΔNLR; 6 weeks post-treatment NLR minus baseline NLR), and their combination. The receiver-operating characteristic curve was used to assess the best cutoff for NLR. Multivariate Cox analysis was used to evaluate the prognostic value of NLR and ΔNLR for patients' survival.

Results: The optimal cutoff for NLR was 4.5. The median follow-up was 25.7 months, baseline NLR ≥4.5, and ΔNLR ≥0, which were independently and significantly associated with shorter overall survival (both P=0.002) and progression-free survival (P=0.004 for NLR and P<0.001 for ΔNLR). Furthermore, simultaneous elevation of the 2 factors was associated with worsened prognosis; patients with both NLR ≥4.5 and ΔNLR ≥0 had significantly increased risk of death [hazards ratio (HR): 10.79, 95% confidence interval (CI): 4.30-27.10] and disease progression (HR: 10.49, 95% CI: 4.39-25.09), compared with both low NLR and ΔNLR patients. Patients with either NLR ≥4.5 or ΔNLR ≥0 showed an intermediate risk for death (HR: 3.12, 95% CI: 1.35-7.21) and progression (HR: 3.45, 95% CI: 1.62-7.36).

Conclusions: High baseline NLR and increased post-treatment NLR might aid in the stratification of high progression and death risk groups in advanced NSCLC patients with poor PS receiving PD-1 inhibitors.
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http://dx.doi.org/10.21037/tlcr-21-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044483PMC
March 2021