Xiaowei Zhuang

Xiaowei Zhuang

UNVERIFIED PROFILE

Are you Xiaowei Zhuang?   Register this Author

Register author
Xiaowei Zhuang

Xiaowei Zhuang

Publications by authors named "Xiaowei Zhuang"

Are you Xiaowei Zhuang?   Register this Author

100Publications

1908Reads

42Profile Views

A robust deep neural network for denoising task-based fMRI data: An application to working memory and episodic memory.

Med Image Anal 2020 Feb 26;60:101622. Epub 2019 Nov 26.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, 80309, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.media.2019.101622DOI Listing
February 2020

Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters.

Hum Brain Mapp 2019 12 12;40(17):5108-5122. Epub 2019 Aug 12.

Lou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Las Vegas, Nevada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24761DOI Listing
December 2019

Unique white matter structural connectivity in early-stage, drug-naive Parkinson disease.

Neurology 2019 Dec 27. Epub 2019 Dec 27.

From Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000008867DOI Listing
December 2019

Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression.

Proc Natl Acad Sci U S A 2019 Sep 9;116(39):19490-19499. Epub 2019 Sep 9.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1912459116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765259PMC
September 2019

Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.

J Cell Biol 2019 Aug 1;218(8):2677-2698. Epub 2019 Jul 1.

Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA

View Article

Download full-text PDF

Source
http://www.jcb.org/lookup/doi/10.1083/jcb.201812076
Publisher Site
http://dx.doi.org/10.1083/jcb.201812076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683742PMC
August 2019

Rotation tracking of genome-processing enzymes using DNA origami rotors.

Nature 2019 08 17;572(7767):136-140. Epub 2019 Jul 17.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1397-7DOI Listing
August 2019

Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons.

Science 2019 08;365(6456):929-934

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaw5937DOI Listing
August 2019

Sex Moderates Amyloid and Apolipoprotein ε4 Effects on Default Mode Network Connectivity at Rest.

Front Neurol 2019 20;10:900. Epub 2019 Aug 20.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710397PMC
August 2019

Multivariate group-level analysis for task fMRI data with canonical correlation analysis.

Neuroimage 2019 07 17;194:25-41. Epub 2019 Mar 17.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, 80309, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2019.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536339PMC
July 2019

Altered functional network topology correlates with clinical measures in very early-stage, drug-naïve Parkinson's disease.

Parkinsonism Relat Disord 2019 05 7;62:3-9. Epub 2019 Feb 7.

Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589361PMC
May 2019

Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization.

Proc Natl Acad Sci U S A 2019 May 13;116(22):10842-10851. Epub 2019 May 13.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1903808116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561216PMC
May 2019

Multiplexed detection of RNA using MERFISH and branched DNA amplification.

Sci Rep 2019 May 22;9(1):7721. Epub 2019 May 22.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, and Department of Physics, Harvard University, Cambridge, MA, 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-43943-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531529PMC
May 2019

Neural correlates of distinct cognitive phenotypes in early Parkinson's disease.

J Neurol Sci 2019 Apr 7;399:22-29. Epub 2019 Feb 7.

University of California San Diego, Department of Neurosciences, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436969PMC
April 2019

Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging.

Proc Natl Acad Sci U S A 2019 04 19;116(14):7071-7076. Epub 2019 Mar 19.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1817222116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452715PMC
April 2019

Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling.

Nat Commun 2019 04 12;10(1):1720. Epub 2019 Apr 12.

Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, 75237, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-019-09657-1
Publisher Site
http://dx.doi.org/10.1038/s41467-019-09657-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461674PMC
April 2019

Influence of analytic techniques on comparing DTI-derived measurements in early stage Parkinson's disease.

Heliyon 2019 Apr 9;5(4):e01481. Epub 2019 Apr 9.

Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, Arizona, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2019.e01481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458486PMC
April 2019

Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth.

Prenat Diagn 2018 12 6;38(13):1042-1048. Epub 2018 Nov 6.

Keck University School of Medicine, University of Southern California, Los Angeles, California.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pd.5374
Publisher Site
http://dx.doi.org/10.1002/pd.5374DOI Listing
December 2018

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria.

Proc Natl Acad Sci U S A 2018 12 3;115(51):13009-13014. Epub 2018 Dec 3.

Department of Chemistry, The Pennsylvania State University, University Park, PA 16802;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1814042115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304990PMC
December 2018

Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells.

Science 2018 10;362(6413)

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology and Department of Physics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aau1783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535145PMC
October 2018

Visualizing and discovering cellular structures with super-resolution microscopy.

Science 2018 08 30;361(6405):880-887. Epub 2018 Aug 30.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aau1044
Publisher Site
http://dx.doi.org/10.1126/science.aau1044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535400PMC
August 2018

Improved mould resistance and antibacterial activity of bamboo coated with ZnO/graphene.

R Soc Open Sci 2018 Aug 15;5(8):180173. Epub 2018 Aug 15.

Zhejiang Provincial Key Laboratory of Biological and Chemical Utilization of Forest Resources, Zhejiang Academy of Forestry, Hangzhou 310023, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsos.180173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124040PMC
August 2018

Investigating structural and perfusion deficits due to repeated head trauma in active professional fighters.

Neuroimage Clin 2018 21;17:616-627. Epub 2017 Nov 21.

Lou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Las Vegas, NV, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716952PMC
July 2018

In Situ Super-Resolution Imaging of Genomic DNA with OligoSTORM and OligoDNA-PAINT.

Methods Mol Biol 2017 ;1663:231-252

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7265-4_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919218PMC
May 2018

Incorporating spatial constraint in co-activation pattern analysis to explore the dynamics of resting-state networks: An application to Parkinson's disease.

Neuroimage 2018 05 28;172:64-84. Epub 2018 Jan 28.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2018.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910213PMC
May 2018

3D spatially-adaptive canonical correlation analysis: Local and global methods.

Neuroimage 2018 04 14;169:240-255. Epub 2017 Dec 14.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2017.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856611PMC
April 2018

Author Correction: Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy.

Sci Rep 2018 Apr 19;8(1):6487. Epub 2018 Apr 19.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA, 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-24844-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906440PMC
April 2018

Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy.

Sci Rep 2018 03 19;8(1):4847. Epub 2018 Mar 19.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA, 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-22297-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859009PMC
March 2018

High-throughput, image-based screening of pooled genetic-variant libraries.

Nat Methods 2017 Dec 30;14(12):1159-1162. Epub 2017 Oct 30.

Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nmeth.4495
Publisher Site
http://dx.doi.org/10.1038/nmeth.4495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958624PMC
December 2017

Multimodal MR Imaging Signatures of Cognitive Impairment in Active Professional Fighters.

Radiology 2017 11 25;285(2):555-567. Epub 2017 Jul 25.

From the Department of Imaging Research, Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W Bonneville Ave, Las Vegas, NV 89106.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.2017162403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673052PMC
November 2017

Blind sparse inpainting reveals cytoskeletal filaments with sub-Nyquist localization.

Optica 2017 Oct 12;4(10):1277-1284. Epub 2017 Oct 12.

Department of Biomedical Engineering, Department of Electrical Engineering, University at Buffalo, the State University of New York, Buffalo, New York 10003, USA.

View Article

Download full-text PDF

Source
https://www.osapublishing.org/abstract.cfm?URI=optica-4-10-1
Publisher Site
http://dx.doi.org/10.1364/OPTICA.4.001277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179357PMC
October 2017

A new algebraic method for quantitative proton density mapping using multi-channel coil data.

Med Image Anal 2017 Aug 23;40:154-171. Epub 2017 Jun 23.

Cleveland Clinic Lou Ruvo Center for Brain Health, 888W. Bonneville Ave, Las Vegas, NV 89106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.media.2017.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568742PMC
August 2017

Structural organization of the actin-spectrin-based membrane skeleton in dendrites and soma of neurons.

Proc Natl Acad Sci U S A 2017 08 24;114(32):E6678-E6685. Epub 2017 Jul 24.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1705043114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559029PMC
August 2017

A family of locally constrained CCA models for detecting activation patterns in fMRI.

Neuroimage 2017 04 29;149:63-84. Epub 2016 Dec 29.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2016.12.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493994PMC
April 2017

Analyzing Single Molecule Localization Microscopy Data Using Cubic Splines.

Sci Rep 2017 04 3;7(1):552. Epub 2017 Apr 3.

Center for Advanced Imaging, Harvard University, Cambridge, MA, 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-00622-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428856PMC
April 2017

The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.

Genes Dev 2017 03 5;31(6):578-589. Epub 2017 Apr 5.

Laboratory for Cell Biology and Genetics, Rockefeller University, New York, New York 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.294108.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393053PMC
March 2017

Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.

PLoS Pathog 2017 02 6;13(2):e1006197. Epub 2017 Feb 6.

School of Molecular and Cellular Biology & Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325612PMC
February 2017

High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing.

Proc Natl Acad Sci U S A 2016 12 22;113(50):14456-14461. Epub 2016 Nov 22.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1617699113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167177PMC
December 2016

High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization.

Proc Natl Acad Sci U S A 2016 09 13;113(39):11046-51. Epub 2016 Sep 13.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138; Department of Physics, Harvard University, Cambridge, MA 02138

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047202PMC
http://dx.doi.org/10.1073/pnas.1612826113DOI Listing
September 2016

Spatial organization of chromatin domains and compartments in single chromosomes.

Science 2016 Aug 21;353(6299):598-602. Epub 2016 Jul 21.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaf8084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991974PMC
August 2016

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells.

Cell 2016 May;165(4):990-1001

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology and Department of Physics, Harvard University, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2016.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905760PMC
May 2016

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

Proc Natl Acad Sci U S A 2016 May 9;113(21):6029-34. Epub 2016 May 9.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; Department of Physics, Harvard University, Cambridge, MA 02138;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1605707113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889411PMC
May 2016

Spatial organization shapes the turnover of a bacterial transcriptome.

Elife 2016 05 20;5. Epub 2016 May 20.

Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.13065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874777PMC
May 2016

An RNA-aptamer-based two-color CRISPR labeling system.

Sci Rep 2016 05 27;6:26857. Epub 2016 May 27.

Howard Hughes Medical Institute, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep26857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882555PMC
May 2016

Stepwise nucleosome translocation by RSC remodeling complexes.

Elife 2016 Feb 19;5. Epub 2016 Feb 19.

Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.10051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769157PMC
February 2016

Correlative stochastic optical reconstruction microscopy and electron microscopy.

PLoS One 2015 15;10(4):e0124581. Epub 2015 Apr 15.

Howard Hughes Medical Institute, Cambridge, Massachusetts, United States of America; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America; Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America; Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124581PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398493PMC
January 2016

Super-resolution imaging reveals distinct chromatin folding for different epigenetic states.

Nature 2016 Jan 13;529(7586):418-22. Epub 2016 Jan 13.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature16496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905822PMC
January 2016

Mapping Synaptic Input Fields of Neurons with Super-Resolution Imaging.

Cell 2015 Oct 1;163(2):493-505. Epub 2015 Oct 1.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Harvard University, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2015.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733473PMC
October 2015

RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells.

Science 2015 Apr 9;348(6233):aaa6090. Epub 2015 Apr 9.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Department of Physics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaa6090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662681PMC
April 2015

Purinosome formation as a function of the cell cycle.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1368-73. Epub 2015 Jan 20.

Chemistry, The Pennsylvania State University, University Park, PA 16802;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1423009112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321313PMC
February 2015

A model for the generation and interconversion of ER morphologies.

Proc Natl Acad Sci U S A 2014 Dec 17;111(49):E5243-51. Epub 2014 Nov 17.

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1419997111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267389PMC
December 2014

A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.

J Cell Biol 2014 Dec;207(6):735-52

Howard Hughes Medical Institute, Chevy Chase, MD 20815 Department of Biochemistry and Department of Radiology, Duke University, Durham, NC 27708

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201407063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274267PMC
December 2014

Developmental mechanism of the periodic membrane skeleton in axons.

Elife 2014 Dec 23;3. Epub 2014 Dec 23.

Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.04581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337613PMC
December 2014

Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA.

Nature 2014 Aug 29;512(7513):213-7. Epub 2014 Jun 29.

1] Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA [2] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA [3] Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134374PMC
August 2014

Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction.

Mol Cell Neurosci 2014 Jul 24;61:241-54. Epub 2014 Jul 24.

The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mcn.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134997PMC
July 2014

Characterization and development of photoactivatable fluorescent proteins for single-molecule-based superresolution imaging.

Proc Natl Acad Sci U S A 2014 Jun 27;111(23):8452-7. Epub 2014 May 27.

Departments of Chemistry and Chemical Biology andPhysics, Harvard University,Howard Hughes Medical Institute, Cambridge, MA 02138

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1406593111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060684PMC
June 2014

Dual function of CD81 in influenza virus uncoating and budding.

PLoS Pathog 2013 10;9(10):e1003701. Epub 2013 Oct 10.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795033PMC
May 2014

Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.

Cell 2014 May;157(4):808-22

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.02.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032590PMC
May 2014

Isotropic 3D Super-resolution Imaging with a Self-bending Point Spread Function.

Nat Photonics 2014 ;8:302-306

Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA ; Department of Physics, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nphoton.2014.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224117PMC
January 2014

Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.

Cell 2013 Oct;155(2):345-356

Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2013.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062873PMC
October 2013

Stochastic optical reconstruction microscopy (STORM): a method for superresolution fluorescence imaging.

Cold Spring Harb Protoc 2013 Jun 1;2013(6):498-520. Epub 2013 Jun 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.top075143DOI Listing
June 2013

Transfection of genetically encoded photoswitchable probes for STORM imaging.

Cold Spring Harb Protoc 2013 Jun 1;2013(6):537-9. Epub 2013 Jun 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.prot075150DOI Listing
June 2013

Preparation of photoswitchable labeled antibodies for STORM imaging.

Cold Spring Harb Protoc 2013 Jun 1;2013(6):540-1. Epub 2013 Jun 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.prot075168DOI Listing
June 2013

Dissecting the role of COPI complexes in influenza virus infection.

J Virol 2013 Mar 19;87(5):2673-85. Epub 2012 Dec 19.

Program in Virology, Harvard Medical School, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02277-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571408PMC
March 2013

Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains.

Nat Struct Mol Biol 2013 Feb 20;20(2):222-9. Epub 2013 Jan 20.

Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565048PMC
February 2013

Live cell imaging of viral entry.

Curr Opin Virol 2013 Feb 7;3(1):34-43. Epub 2013 Feb 7.

Program in Virology, Harvard Medical School, Boston, MA 02115, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2013.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587724PMC
February 2013

Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.

J Cell Biol 2013 Feb 11;200(4):419-28. Epub 2013 Feb 11.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201206096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575536PMC
February 2013

Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons.

Science 2013 Jan 13;339(6118):452-6. Epub 2012 Dec 13.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1232251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815867PMC
January 2013

Phosphine quenching of cyanine dyes as a versatile tool for fluorescence microscopy.

J Am Chem Soc 2013 Jan 17;135(4):1197-200. Epub 2013 Jan 17.

Howard Hughes Medical Institute, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja3105279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624894PMC
January 2013

Monitoring conformational dynamics with single-molecule fluorescence energy transfer: applications in nucleosome remodeling.

Methods Enzymol 2012 ;513:59-86

Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-391938-0.00003-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023429PMC
December 2012

Ultrabright photoactivatable fluorophores created by reductive caging.

Nat Methods 2012 Dec 28;9(12):1181-4. Epub 2012 Oct 28.

Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.2214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561463PMC
December 2012

Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes.

Proc Natl Acad Sci U S A 2012 Aug 13;109(35):13978-83. Epub 2012 Aug 13.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1201882109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435176PMC
August 2012

3D multicolor super-resolution imaging offers improved accuracy in neuron tracing.

PLoS One 2012 24;7(1):e30826. Epub 2012 Jan 24.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030826PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265519PMC
June 2012

Statistical deconvolution for superresolution fluorescence microscopy.

Biophys J 2012 May 15;102(10):2391-400. Epub 2012 May 15.

Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2012.03.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353000PMC
May 2012

A high-density 3D localization algorithm for stochastic optical reconstruction microscopy.

Opt Nanoscopy 2012 ;1(6)

Center for Brain Science, Harvard University Department of Chemistry and Chemical Biology, Harvard University Department of Physics, Harvard University Howard Hughes Medical Institute Cambridge, MA. 02138.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2192-2853-1-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243665PMC
January 2012

Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection.

Chemphyschem 2012 Jan 23;13(1):99-107. Epub 2011 Dec 23.

School of Engineering and Applied Sciences, Graduate program in Biophysics, Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cphc.201100735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353744PMC
January 2012

Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeleton.

Nat Methods 2012 Jan 8;9(2):185-8. Epub 2012 Jan 8.

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.1841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304438PMC
January 2012

Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging.

Nat Methods 2011 Nov 6;8(12):1027-36. Epub 2011 Nov 6.

Graduate program in Biophysics, Harvard University, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.1768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272503PMC
November 2011

New fluorescent probes for super-resolution imaging.

Nat Biotechnol 2011 Oct 13;29(10):880-1. Epub 2011 Oct 13.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222936PMC
October 2011

Single-virus tracking in live cells.

Cold Spring Harb Protoc 2011 Sep 1;2011(9). Epub 2011 Sep 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/pdb.top065623DOI Listing
September 2011

Chromosome organization by a nucleoid-associated protein in live bacteria.

Science 2011 Sep;333(6048):1445-9

Department of Physics, Harvard University, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1204697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329943PMC
September 2011