Publications








Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure.
Gut 2017 Sep 19. Epub 2017 Sep 19.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Oncogenic RAS Regulates Long Noncoding RNAin Human Cancer.
Cancer Res 2017 Jul 4;77(14):3745-3757. Epub 2017 May 4.
Center for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.


DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.
Nat Commun 2017 Apr 27;8:15164. Epub 2017 Apr 27.
The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.

A 4-bp Insertion at ZmPLA1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize.
Mol Plant 2017 Mar 4;10(3):520-522. Epub 2017 Feb 4.
National Maize Improvement Center of China, Key Laboratory of Crop Heterosis and Utilization (MOE), China Agricultural University, No. 2 Yuan Ming Yuan West Road, Haidian District, Beijing 100193, China. Electronic address:

Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation.
ACS Appl Mater Interfaces 2016 Dec 21;8(48):32706-32716. Epub 2016 Nov 21.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.

Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer.
Mol Cell Biol 2016 Nov 13;36(21):2742-2754. Epub 2016 Oct 13.
Center for Research on Reproduction & Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo.
Cancer Chemother Pharmacol 2016 Nov 12;78(5):971-982. Epub 2016 Sep 12.
Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.







Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.
Cell Rep 2016 Apr 24;15(1):171-80. Epub 2016 Mar 24.
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Serum macrophage inflammatory protein 3α levels predict the severity of HBV-related acute-on-chronic liver failure.
Gut 2016 Feb 3;65(2):355-7. Epub 2015 Jun 3.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors.
Clin Cancer Res 2016 Feb 21;22(4):1018-27. Epub 2015 Oct 21.
The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China.

Bacterial coinfection is associated with severity of avian influenza A (H7N9), and procalcitonin is a useful marker for early diagnosis.
Diagn Microbiol Infect Dis 2016 Feb 28;84(2):165-9. Epub 2015 Oct 28.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address:




A highly sensitive and flexible magnetic nanoprobe labeled immunochromatographic assay platform for pathogen Vibrio parahaemolyticus.
Int J Food Microbiol 2015 Oct 9;211:109-16. Epub 2015 Jul 9.
College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation, Ministry of Agriculture, Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai Ocean University, No. 999, Huchenghuan Road, Shanghai 201306, PR China.

The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
Sci Signal 2015 Sep 1;8(392):ra87. Epub 2015 Sep 1.
Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.



miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment.
Pigment Cell Melanoma Res 2015 Jul 16;28(4):431-41. Epub 2015 May 16.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.
Nat Commun 2015 Jun 10;6:7209. Epub 2015 Jun 10.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Evaluation of plasma exchange and continuous veno-venous hemofiltration for the treatment of severe avian influenza A (H7N9): a cohort study.
Ther Apher Dial 2015 Apr 3;19(2):178-84. Epub 2014 Nov 3.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.


Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Nature 2015 Apr 9;520(7547):373-7. Epub 2015 Mar 9.
1] Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [4] Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.


Specific recognition of guanines in non-duplex regions of nucleic acids with potassium tungstate and hydrogen peroxide.
Nucleic Acids Res 2015 Jan 29;43(1):e3. Epub 2014 Oct 29.
College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, P. R. China

Immune activation and a 9-year ongoing complete remission following CD40 antibody therapy and metastasectomy in a patient with metastatic melanoma.
Cancer Immunol Res 2014 Nov 24;2(11):1051-8. Epub 2014 Sep 24.
Abramson Cancer Center, University of Pennsylvania, Philadelphia. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Histomorphologic assessment and interobserver diagnostic reproducibility of atypical spitzoid melanocytic neoplasms with long-term follow-up.
Am J Surg Pathol 2014 Jul;38(7):934-40
*Department of Dermatology †Robert H. Lurie Cancer Center †††Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL ‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY §Department of Pathology and Laboratory Medicine, Dermatopathology, UCLA Medical Center, Los Angeles ‡‡Departments of Pathology and Dermatology, University of California, San Francisco, San Francisco, CA ¶Pathology Service, Massachusetts General Hospital, Boston, MA #Department of Pathology, University of Pennsylvania, Philadelphia ¶¶Rabkin Dermatopathology Laboratory, P.C., Tarentum, PA Departments of **Pathology ††Dermatology, University of Michigan Medical Center, Ann Arbor, MI §§Department of Pathology, Section of Dermatopathology ∥∥Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX ∥Department of Histopathology, Royal Surrey County Hospital & Division of Clinical Medicine, University of Surrey, Guildford, Surrey, UK ##Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Melanoma Institute Australia and The University of Sydney, NSW, Australia ***Departments of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A novel aggregation-induced emission fluorescent probe for nucleic acid detection and its applications in cell imaging.
Bioorg Med Chem Lett 2014 Apr 5;24(7):1654-6. Epub 2014 Mar 5.
College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Hubei, Wuhan 430072, PR China. Electronic address:



Oncogenic BRAF-Mediated Melanoma Cell Invasion.
Cell Rep 2016 05 19;15(9):2012-24. Epub 2016 May 19.
Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
J Biol Chem 2017 01 15;292(4):1351-1360. Epub 2016 Dec 15.
From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and


CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early Gphase to initiate a new cell cycle in HeLa cells.
J Biol Chem 2017 06 26;292(24):10131-10141. Epub 2017 Apr 26.
From the Ministry of Education Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China,




Corrigendum to "A novel intestinal-restricted FXR agonist" [Bioorg Med Chem Lett 27 (2017) 3386-3390].
Bioorg Med Chem Lett 2017 12 27;27(23):5353. Epub 2017 Oct 27.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China. Electronic address:

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