Xiaowei Xu

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Xiaowei Xu

Publications by authors named "Xiaowei Xu"

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100Publications

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Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging.

Anal Chem 2018 Jun 11. Epub 2018 Jun 11.

CAS Key Laboratory of Receptor Research, Synthetic Organic and Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai 201203 , China.

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June 2018

Assessment of patients' warfarin knowledge and anticoagulation control at a joint physician- and pharmacist-managed clinic in China.

Patient Prefer Adherence 2018 9;12:783-791. Epub 2018 May 9.

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

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May 2018

Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis.

Cancer Lett 2018 May 30;431:150-160. Epub 2018 May 30.

Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, NO.19A Yuquan Road, Beijing, 100049, China. Electronic address:

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May 2018

Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.

Int J Nanomedicine 2018 28;13:187-198. Epub 2017 Dec 28.

Department of Pathology, School and Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.

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March 2018

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles.

Methods Mol Biol 2016 ;1453:49-55

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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January 2018

Control of arsenic mobilization in paddy soils by manganese and iron oxides.

Environ Pollut 2017 Dec 4;231(Pt 1):37-47. Epub 2017 Aug 4.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China; Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. Electronic address:

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December 2017

Corrigendum to "A novel intestinal-restricted FXR agonist" [Bioorg Med Chem Lett 27 (2017) 3386-3390].

Bioorg Med Chem Lett 2017 12 27;27(23):5353. Epub 2017 Oct 27.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China. Electronic address:

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December 2017

Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma.

Oncotarget 2017 Dec 5;8(70):115140-115152. Epub 2017 Dec 5.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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December 2017

Integrated Energy Aerogel of N,S-rGO/WSe/NiFe-LDH for Both Energy Conversion and Storage.

ACS Appl Mater Interfaces 2017 Sep 15;9(38):32756-32766. Epub 2017 Sep 15.

Institute Special Materials and Technology, Fudan University , Shanghai 200433, China.

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September 2017

Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure.

Gut 2017 Sep 19. Epub 2017 Sep 19.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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September 2017

A novel intestinal-restricted FXR agonist.

Bioorg Med Chem Lett 2017 08 3;27(15):3386-3390. Epub 2017 Jun 3.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang#24, Nanjing 210009, China. Electronic address:

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August 2017

Oncogenic RAS Regulates Long Noncoding RNA in Human Cancer.

Cancer Res 2017 07 4;77(14):3745-3757. Epub 2017 May 4.

Center for Research on Reproduction & Women's Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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July 2017

CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G phase to initiate a new cell cycle in HeLa cells.

J Biol Chem 2017 06 26;292(24):10131-10141. Epub 2017 Apr 26.

From the Ministry of Education Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China,

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June 2017

High ALDH1 expression correlates with better prognosis in tumorigenic malignant melanoma.

Mod Pathol 2017 May 20;30(5):634-639. Epub 2017 Jan 20.

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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May 2017

Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines.

Tumour Biol 2017 Apr;39(4):1010428317695964

1 Department of Hematology, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China.

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April 2017

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.

Nat Commun 2017 Apr 27;8:15164. Epub 2017 Apr 27.

The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China.

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April 2017

A 4-bp Insertion at ZmPLA1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize.

Mol Plant 2017 Mar 4;10(3):520-522. Epub 2017 Feb 4.

National Maize Improvement Center of China, Key Laboratory of Crop Heterosis and Utilization (MOE), China Agricultural University, No. 2 Yuan Ming Yuan West Road, Haidian District, Beijing 100193, China. Electronic address:

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March 2017

Surface Tension Components Ratio: An Efficient Parameter for Direct Liquid Phase Exfoliation.

ACS Appl Mater Interfaces 2017 Mar 6;9(10):9168-9175. Epub 2017 Mar 6.

Institute of Special Materials and Technology, Fudan University , Shanghai 200433, China.

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March 2017

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

J Biol Chem 2017 01 15;292(4):1351-1360. Epub 2016 Dec 15.

From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and

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January 2017

Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification.

Anal Chem 2017 Jan 28;89(2):1229-1237. Epub 2016 Dec 28.

Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University , Tongjiaxiang #24, Nanjing 21009, China.

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January 2017

Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation.

ACS Appl Mater Interfaces 2016 Dec 21;8(48):32706-32716. Epub 2016 Nov 21.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. China.

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December 2016

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway.

Med Sci Monit 2016 Dec 27;22:5141-5153. Epub 2016 Dec 27.

Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

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December 2016

A Visual Analytics Approach for Station-Based Air Quality Data.

Sensors (Basel) 2016 Dec 24;17(1). Epub 2016 Dec 24.

Department of Big Data Technology and Application Development, Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.

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December 2016

Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer.

Mol Cell Biol 2016 Nov 13;36(21):2742-2754. Epub 2016 Oct 13.

Center for Research on Reproduction & Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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November 2016

Miscoding of Melanoma Thickness in SEER: Research and Clinical Implications.

J Invest Dermatol 2016 11 25;136(11):2168-2172. Epub 2016 Jun 25.

Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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November 2016

JD enhances the anti-tumour effects of low-dose paclitaxel on gastric cancer MKN45 cells both in vitro and in vivo.

Cancer Chemother Pharmacol 2016 Nov 12;78(5):971-982. Epub 2016 Sep 12.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou University School of Pharmaceutical Sciences, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.

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November 2016

Detection of Long Noncoding RNA Expression by Nonradioactive Northern Blots.

Methods Mol Biol 2016 ;1402:177-188

Center for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd., 1207 Biomedical Research Building II/III, Philadelphia, PA, 19104, USA.

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October 2016

Body-Earth Mover's Distance: A Matching-Based Approach for Sleep Posture Recognition.

IEEE Trans Biomed Circuits Syst 2016 10 28;10(5):1023-1035. Epub 2016 Jul 28.

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October 2016

Cryptococcal cellulitis in a heart transplant recipient.

JAAD Case Rep 2016 Sep 11;2(5):403-405. Epub 2016 Oct 11.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

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September 2016

Sporotrichoid fluctuant nodules.

Cutis 2016 Aug;98(2):82;96

Department of Dermatology, University of Pennsylvania, Philadelphia, USA.

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August 2016

Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population.

PLoS One 2015 28;10(12):e0145399. Epub 2015 Dec 28.

Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

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July 2016

Controlled synthesis and comparison of NiCo2S4/graphene/2D TMD ternary nanocomposites for high-performance supercapacitors.

Chem Commun (Camb) 2016 Jul 29;52(59):9251-4. Epub 2016 Jun 29.

Institute of Special Materials and Technology, Fudan University, Shanghai, 200433, China.

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July 2016

Cobalt-Doped FeSe2-RGO as Highly Active and Stable Electrocatalysts for Hydrogen Evolution Reactions.

ACS Appl Mater Interfaces 2016 Jul 7;8(28):18036-42. Epub 2016 Jul 7.

Institute of Special Materials and Technology, Fudan University , Shanghai 200433, China.

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July 2016

High Light Absorption and Charge Separation Efficiency at Low Applied Voltage from Sb-Doped SnO2/BiVO4 Core/Shell Nanorod-Array Photoanodes.

Nano Lett 2016 Jun 26;16(6):3463-74. Epub 2016 May 26.

Department of Mechanical Engineering, Worcester Polytechnic Institute , Worcester, Massachusetts 01609, United States.

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June 2016

Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection.

Cell Host Microbe 2016 Jun 19;19(6):775-87. Epub 2016 May 19.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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June 2016

pH- and Temperature-Sensitive Hydrogel Nanoparticles with Dual Photoluminescence for Bioprobes.

ACS Nano 2016 Jun 16;10(6):5856-63. Epub 2016 Jun 16.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.

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June 2016

Oncogenic BRAF-Mediated Melanoma Cell Invasion.

Cell Rep 2016 05 19;15(9):2012-24. Epub 2016 May 19.

Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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May 2016

Detecting Lung Diseases from Exhaled Aerosols: Non-Invasive Lung Diagnosis Using Fractal Analysis and SVM Classification.

PLoS One 2015 30;10(9):e0139511. Epub 2015 Sep 30.

Department of Information Science, University of Arkansas, Little Rock, Arkansas, United States of America.

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April 2016

DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation.

J Cell Sci 2016 Apr 12;129(7):1429-40. Epub 2016 Feb 12.

The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871, China

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April 2016

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.

Cell Rep 2016 Apr 24;15(1):171-180. Epub 2016 Mar 24.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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April 2016

A novel approach for the detection and genetic analysis of live melanoma circulating tumor cells.

PLoS One 2015 25;10(3):e0123376. Epub 2015 Mar 25.

Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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March 2016

Serum macrophage inflammatory protein 3α levels predict the severity of HBV-related acute-on-chronic liver failure.

Gut 2016 Feb 3;65(2):355-7. Epub 2015 Jun 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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February 2016

Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors.

Clin Cancer Res 2016 Feb 21;22(4):1018-27. Epub 2015 Oct 21.

The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China.

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February 2016

Bacterial coinfection is associated with severity of avian influenza A (H7N9), and procalcitonin is a useful marker for early diagnosis.

Diagn Microbiol Infect Dis 2016 Feb 28;84(2):165-9. Epub 2015 Oct 28.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address:

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February 2016

Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.

Oncologist 2016 Jan 27;21(1):84-94. Epub 2015 Nov 27.

Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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January 2016

TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles.

Lab Invest 2016 Jan 2;96(1):81-8. Epub 2015 Nov 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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January 2016

[Carotid plaque characteristics detected with 3.0T high resolution nuclear magnetic resonance imaging in patients with coronary artery disease].

Zhonghua Xin Xue Guan Bing Za Zhi 2016 Jan;44(1):38-42

Department of Cardiology, Tiantan Hospital, Capital Medical University, Beijing 100050, China.

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January 2016

Identification of secreted proteins that reflect autophagy dynamics within tumor cells.

Autophagy 2015 ;11(1):60-74

a Center for Systems and Computational Biology; The Wistar Institute ; Philadelphia , PA USA.

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November 2015

The Chinese Ebola Diagnostic and Treatment Center in Liberia as a model center.

Emerg Microbes Infect 2015 Nov 25;4(11):e71. Epub 2015 Nov 25.

Tangdu Hospital, The Second Affiliated Hospital, Forth Military Medical University, Shanxi 710038, Xi'an Province, China.

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November 2015

A highly sensitive and flexible magnetic nanoprobe labeled immunochromatographic assay platform for pathogen Vibrio parahaemolyticus.

Int J Food Microbiol 2015 Oct 9;211:109-16. Epub 2015 Jul 9.

College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation, Ministry of Agriculture, Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai Ocean University, No. 999, Huchenghuan Road, Shanghai 201306, PR China.

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October 2015

The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.

Sci Signal 2015 Sep 1;8(392):ra87. Epub 2015 Sep 1.

Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.

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September 2015

Perfusion-weighted magnetic resonance imaging detects recurrent isolated vertigo caused by cerebral hypoperfusion.

Int J Neurosci 2015 Jun 25;125(6):449-55. Epub 2014 Sep 25.

1Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

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June 2015

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.

Nat Commun 2015 Jun 10;6:7209. Epub 2015 Jun 10.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

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June 2015

Asymmetric author-topic model for knowledge discovering of big data in toxicogenomics.

Front Pharmacol 2015 20;6:81. Epub 2015 Apr 20.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration Jefferson, AR, USA.

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May 2015

Evaluation of plasma exchange and continuous veno-venous hemofiltration for the treatment of severe avian influenza A (H7N9): a cohort study.

Ther Apher Dial 2015 Apr 3;19(2):178-84. Epub 2014 Nov 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

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April 2015

Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure.

Chem Res Toxicol 2015 Apr 9;28(4):738-51. Epub 2015 Mar 9.

†National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.

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April 2015

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.

Nature 2015 Apr 9;520(7547):373-7. Epub 2015 Mar 9.

1] Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [4] Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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April 2015

Correction: Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions.

Org Biomol Chem 2015 Apr;13(15):4613

College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, P. R. China.

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April 2015

Specific recognition of guanines in non-duplex regions of nucleic acids with potassium tungstate and hydrogen peroxide.

Nucleic Acids Res 2015 Jan 29;43(1):e3. Epub 2014 Oct 29.

College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan 430072, P. R. China

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January 2015

Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors.

Nat Commun 2014 Dec 16;5:5807. Epub 2014 Dec 16.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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December 2014

Generation of hepatitis B virus PreS2-S antigen in Hansenula polymorpha.

Virol Sin 2014 Dec 24;29(6):403-9. Epub 2014 Dec 24.

State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, 210009, China.

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December 2014

Interference-Free HER2 ECD as a Serum Biomarker in Breast Cancer.

J Mol Biomark Diagn 2014 Nov;4(3):151

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, U.S.A.

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November 2014

Immune activation and a 9-year ongoing complete remission following CD40 antibody therapy and metastasectomy in a patient with metastatic melanoma.

Cancer Immunol Res 2014 Nov 24;2(11):1051-8. Epub 2014 Sep 24.

Abramson Cancer Center, University of Pennsylvania, Philadelphia. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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November 2014

Electrowetting on dielectric device with crescent electrodes for reliable and low-voltage droplet manipulation.

Biomicrofluidics 2014 Nov 24;8(6):064107. Epub 2014 Nov 24.

College of Mechanical Engineering, Quzhou University , Quzhou 324000, China.

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November 2014

A phenome-guided drug repositioning through a latent variable model.

BMC Bioinformatics 2014 Aug 8;15:267. Epub 2014 Aug 8.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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August 2014

Composite photothermal platform of polypyrrole-enveloped Fe₃O₄ nanoparticle self-assembled superstructures.

ACS Appl Mater Interfaces 2014 Aug 18;6(16):14552-61. Epub 2014 Aug 18.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, People's Republic of China.

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August 2014