Publications by authors named "Xiaosong Zhang"

87 Publications

Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process.

Phytomedicine 2021 Dec 31;97:153920. Epub 2021 Dec 31.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu 730070, China. Electronic address:

Background: Liver damage is one of the most common complications in humans and animals after heat stress (HS). Sheng Mai San (SMS), a traditional Chinese medicine prescription that originated in the Jin Dynasty, exert a therapeutic effect on HS. However, how SMS prevents liver injury after heat exposure remains unknown.

Purpose: This study aimed to investigate the pharmacological effect and molecular mechanisms of SMS on HS-induced liver injury.

Study Design: A comprehensive strategy via incorporating pharmacodynamics, targeted metabolomics, and molecular biology technology was adopted to investigate energy metabolism changes and the therapeutic mechanisms of SMS in HS-induced rat liver injury.

Methods: First, Sprague-Dawley rats were subjected to HS (38 °C/ 75% RH/ 2 h/ day) for 7 consecutive days to establish the HS model, and SMS was given orally for treatment 2 h before heat exposure. Thereafter, liver function and pathological changes in liver tissue were evaluated. Finally, the underlying mechanisms of SMS were determined using targeted energy metabolomics to comprehensively analyze the metabolic pathways and were further verified through Western-blot and qRT-PCR assays.

Results: Our results showed that SMS alleviated HS-induced liver dysfunction by reducing the alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST/ALT ratios in serum and improving hepatic pathological damage. Meanwhile, SMS suppressed inflammatory response, oxidative injury, and overexpression of heat shock proteins in liver tissue after heat exposure. With the help of targeted energy metabolomics, we found that SMS could effectively regulate glycolysis and tricarboxylic acid (TCA) cycle to relieve energy metabolism disorder. Furthermore, we confirmed that SMS can facilitate the phosphorylation of AMP-activated protein kinase (AMPK) to maintain mitochondrial homeostasis through a dynamin protein 1 (Drp1)-dependent mitophagy process.

Conclusion: On the basis of energy metabolomics, the present study for the first time systematically illustrated the protective effect of SMS on HS-induced liver injury, and preliminarily confirmed that an AMPK-mediated Drp1-dependent mitophagy and mitochondria rebuilding process plays an important role in SMS intervention on HS-induced rat liver. Together, our study lends further support to the use of SMS in treating HS condition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2021.153920DOI Listing
December 2021

Self-Powered Sensing for Non-Full Pipe Fluidic Flow Based on Triboelectric Nanogenerators.

ACS Appl Mater Interfaces 2022 Jan 7. Epub 2022 Jan 7.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Fluidic flow monitoring of a non-full pipe is of great significance in the field of energy measurement and pipeline transportation. In this work, a monitoring method based on triboelectric nanogenerators for non-full pipe fluidic flow of large pipelines is proposed. Specifically, a triboelectric non-full pipe flow sensor (TNPFS) is fabricated, which can monitor the flow velocity and the liquid level simultaneously, and then the flow can be obtained by conversion. For flow velocity monitoring, the flexible blades slide between electrodes, generating periodic electrical signals. Interestingly, the frequencies of the voltage and flow velocities show a good linear relationship. For liquid level monitoring, according to the principle of liquid-solid contact electrification, a variable area interdigital electrode with a stable signal distributed on a polytetrafluoroethylene tube is designed. The experiments demonstrate that the peak number and trend of the voltage derivative curve are related to the liquid level. Finally, a real-time flow-monitoring system is established to effectively monitor the flow from 94 to 264 L/min. Compared with the actual measured flow, the error rate is under 1.95%. In addition to this, the TNPFS also has good responsiveness in sewage. This work provides a novel method for fluidic flow monitoring, especially the non-full pipe flow of large pipelines.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.1c20509DOI Listing
January 2022

An Efficient Privacy-Preserving Public Auditing Protocol for Cloud-based Medical Storage System.

IEEE J Biomed Health Inform 2022 Jan 6;PP. Epub 2022 Jan 6.

The booming Internet of Things makes smart healthcare a reality, while cloud-based medical storage systems solve the problems of large-scale storage and real-time access of medical data. The integrity of medical data outsourced in cloud-based medical storage systems has become crucial since only complete data can make a correct diagnosis, and public auditing protocol is a key technique to solve this problem. To guarantee the integrity of medical data and reduce the burden of the data owner, we propose an efficient privacy-preserving public auditing protocol for the cloud-based medical storage systems, which supports the functions of batch auditing and dynamic update of data. Detailed security analysis shows that our protocol is secure under the defined security model. In addition, we have conducted extensive performance evaluations, and the results indicate that our protocol not only remarkably reduces the computational costs of both the data owner and the third-party auditor (TPA), but also significantly improves the communication efficiency between the TPA and the cloud server. Specifically, compared with other related work, the computational cost of the TPA in our protocol is negligible and the data owner saves more than 2/3 of computational cost. In addition, as the number of challenged blocks increases, our protocol saves nearly 90% of communication overhead between the TPA and the cloud server.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2022.3140831DOI Listing
January 2022

Phase Ib Study of Atezolizumab Plus Interferon-α with or without Bevacizumab in Patients with Metastatic Renal Cell Carcinoma and Other Solid Tumors.

Curr Oncol 2021 Dec 20;28(6):5466-5479. Epub 2021 Dec 20.

Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.

This Phase Ib study combined programmed death-ligand 1 inhibitor, atezolizumab, with other immunomodulatory agents in locally advanced and metastatic solid tumors. Arms B-D evaluated atezolizumab plus interferon-α, with/without vascular endothelial growth factor inhibitor, bevacizumab, in renal cell carcinoma (RCC) and other solid tumors. Arm B predominantly recruited patients with previously treated RCC or melanoma to receive atezolizumab plus interferon α-2b. Arm C investigated atezolizumab plus polyethylene glycol (PEG)-interferon α-2a in previously treated RCC. Arm D evaluated atezolizumab plus PEG-interferon α-2a and bevacizumab. Primary objectives were safety and tolerability; secondary objectives included clinical activity. Combination therapy was well tolerated, with safety profiles consistent with known risks of individual agents. The most frequent treatment-related toxicities were fatigue, chills, and pyrexia. The objective response rate (ORR) in arm B was 20.0% overall and 17.8% in patients with previously treated checkpoint inhibitor-naive RCC ( = 45). No responses were reported in arm C. The highest ORR in arm D was 46.7% in patients with treatment-naive RCC ( = 15). Data showed preliminary clinical activity and acceptable tolerability of atezolizumab plus interferon α-2b in patients with previously treated checkpoint inhibitor-naive RCC and of atezolizumab plus PEG-interferon α-2a and bevacizumab in patients with treatment-naive RCC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/curroncol28060455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700717PMC
December 2021

Association of Nighttime Sleep Duration with Depressive Symptoms and Its Interaction with Regular Physical Activity among Chinese Adolescent Girls.

Int J Environ Res Public Health 2021 10 25;18(21). Epub 2021 Oct 25.

Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'anmen Street, Xicheng District, Beijing 100034, China.

Depression has become a major mental health concern among adolescents globally, and the relationship between depressive symptoms and nighttime sleep duration among adolescent girls remains unclear. This study aimed to examine the association between nighttime sleep duration and depressive symptoms among Chinese adolescent girls. This cross-sectional study, conducted in 2018, included 4952 girls aged 10-19 years from the eastern, central, and western regions of China. Depressive symptoms were assessed by the Patient Health Questionnaire-9, and categorized into depressive symptoms and non-depressive symptoms. Logistic regression models were used to estimate the odds ratios (ORs) of depressive symptoms. After adjustment for covariates, adolescent girls with a nighttime sleep duration of <7 h/night (OR = 2.28, 95% CI: 1.76-2.95) and 7 h/night (OR = 1.82, 95% CI: 1.48-2.24) were associated with increased risk of depressive symptoms, compared to those with a sleep duration of 8 h/night. An interaction between nighttime sleep duration and regular physical activity on the risk of depressive symptoms was observed ( for interaction = 0.036). Among both girls with and without regular physical activity, a sleep duration of <7 h/night was associated with increased odds of depressive symptoms, and the magnitude of the ORs among girls with regular physical activity was lower than those without regular physical activity. This study found a significant association of short nighttime sleep duration with increased risk of depressive symptoms, and demonstrates the importance of maintaining adequate nighttime sleep duration and ensuring regular physical activity in improving depressive symptoms among adolescent girls.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph182111199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583044PMC
October 2021

Nonintrusion Monitoring of Droplet Motion State Liquid-Solid Contact Electrification.

ACS Nano 2021 Oct 21. Epub 2021 Oct 21.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Droplet motion state monitoring is important in microfluidic applications, such as biomedicine, drug delivery, and metal ion extraction. Here, a nonintrusion monitoring method of droplet motion state liquid-solid contact electrification is proposed, and a triboelectric droplet motion state sensor (TDMSS) is fabricated. Droplet counting and droplet size monitoring can be realized by signal processing and information extracting of the voltage pulse. The experimental results show that the number of droplets increases linearly with the increase of liquid flow, and the linearity is 0.9854. Moreover, TDMSS can stably monitor the number of droplets in different motion states. In addition, the output pulse width is sensitive to droplet size, and the droplet length ranges from 3 to 13.5 mm. More importantly, TDMSS can realize the function of droplet counting and size monitoring of a conductive liquid and accurate droplet counting under different inclination angles and motion states. This work not only provides a nonintrusion method for droplet motion state monitoring but also makes a solid step for microfluidic sensing technology based on a triboelectric nanogenerator.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.1c08691DOI Listing
October 2021

Prevalence and risk factors for menopausal symptoms in middle-aged Chinese women: a community-based cross-sectional study.

Menopause 2021 Aug 30;28(11):1271-1278. Epub 2021 Aug 30.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Objectives: To examine the prevalence and risk factors of menopausal symptoms in middle-aged Chinese women.

Methods: A cross-sectional, community-based study recruited 6,745 women aged 40 to 55 years in the eastern, central, and western regions of China during 2018. Menopausal status was categorized into reproductive stage (defined as regular menstruation or subtle changes in menstrual cycle characteristics), menopausal transition (the beginning of a persistent difference of 7 d in the length of consecutive cycles, or the last menstruation having occurred no more than 12 mo), or postmenpause (the end of the 12 mo period of amenorrhea) according to the Stages of Reproductive Aging Workshop classification. Menopausal symptoms were determined by the modified Kupperman Menopausal Index (KMI) questionnaire and considered nonmenopausal symptoms (total KMI score<15) and menopausal symptoms (total KMI score≥15). Demographic, lifestyle, physical, and menopausal characteristics were collected by face-to-face interviews. Logistic regression models were used to identify factors associated with the risk of menopausal symptoms.

Results: Among all participants, the mean age was 46.9 years, and 15.7% (1,001/6,364) of participants reported experiencing menopausal symptoms. The prevalence of menopausal symptoms was 9.3% (303/3,256), 23.9% (293/1,227), and 21.5% (405/1,881) in the reproductive stage, menopausal transition, and postmenopausal stage, respectively. Overall, the three most prevalent menopausal symptoms were insomnia (44.7%), fatigue (40.4%), and mood swings (37.2%). The multivariable logistic regression model showed that menopausal status, residence, nulliparity, and chronic diseases were associated with the risk of menopausal symptoms (all P < 0.05). Women during menopausal transition (OR = 2.66, 95% CI: 2.21-3.20) or postmenopause (OR = 2.26, 95% CI: 1.82-2.80) had significantly increased risk of menopausal symptoms compared with those in the reproductive stage.

Conclusions: Menopausal status, residence, nulliparity, and chronic diseases were associated with menopausal symptoms in middle-aged Chinese women.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/GME.0000000000001850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547757PMC
August 2021

Safety and Clinical Activity of Atezolizumab Plus Ipilimumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Results From a Phase 1b Trial.

Clin Lung Cancer 2021 Jul 20. Epub 2021 Jul 20.

Genentech, Inc, South San Francisco, CA.

Background: This phase 1b study investigated safety and activity of combined checkpoint inhibition (CPI) with programmed death-ligand 1 (PD-L1) antibody atezolizumab plus cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor ipilimumab in NSCLC.

Patients And Methods: Eligible patients had previously treated locally advanced or metastatic non-small cell lung cancer (NSCLC) or melanoma. A standard 3+3 dose escalation investigated atezolizumab (600-1200 mg IV every 3 weeks) plus ipilimumab starting at 1 mg/kg, administered as a single dose or 4 doses, administered every 3 weeks. The expansion stage included a cohort previously treated with atezolizumab. Patients were monitored for safety and tolerability; response was evaluated every 6 weeks.

Results: Twenty-seven patients were enrolled, 4 with melanoma and 23 with NSCLC; here, we focus on data for the NSCLC population. Three of 23 patients (13.0%) received prior CPI. No dose-limiting toxicities were reported during dose escalation; dose expansion occurred with atezolizumab 1200 mg plus 1 cycle of ipilimumab 1 mg/kg. Most common treatment-emergent adverse events were dyspnea (39%) and cough (35%); treatment-related Grade ≥3 adverse events occurred in 11 patients (48%), most frequently pneumonitis (17%) and amylase or lipase elevation (9% each). Six of 23 NSCLC patients (26%) achieved confirmed responses, 5 of whom (25%) were CPI naive. Median duration of response was 23.0 (95% CI, 3.2-36.9) months overall and 36.9 (95% CI, 2.9-36.9) months in CPI-naive patients.

Conclusion: Preliminary efficacy of atezolizumab plus ipilimumab was observed in metastatic NSCLC. The combination had manageable toxicity, with a safety profile consistent with those of the individual agents.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2021.07.002DOI Listing
July 2021

Successful Endovascular Treatment of a Spontaneous Rupture of the Ascending Lumbar Vein: A Case Report.

Vasc Endovascular Surg 2022 Jan 22;56(1):70-74. Epub 2021 Jul 22.

Department of Vascular Surgery, 117961The First People's Hospital of Lianyungang, Lianyungang, Jiangsu Province, China.

Although there have been a few case reports of spontaneous rupture of pelvic veins, such as the iliac vein, to date, there have been no reports of spontaneous rupture of the ascending lumbar vein. Here, we report a case of spontaneous rupture of the ascending lumbar vein for the first time. A 66-year-old woman visited the emergency department due to the swelling of the left lower limb for 2 hours. After admission, the patient developed symptoms of pain in the left lumbar region, as well as symptoms of shock, such as increased heart rate and decreased blood pressure. During emergency venography, it was found that the ascending lumbar vein was ruptured, which was accompanied by the compression and occlusion of the iliac vein (May-Thurner syndrome). During the endovascular surgical treatment, a covered stent was placed in the iliac vein, and the occluded common iliac vein was treated with a bare stent. Immediately after the surgical procedure, the patient's abdominal computed tomography examination showed the formation of a large retroperitoneal haematoma, and continuous routine blood parameter monitoring showed that haemoglobin was stable. Postoperative recovery was uneventful, and the patient was discharged on the ninth postoperative day.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/15385744211032464DOI Listing
January 2022

Association of Gestational Diabetes Mellitus with Adverse Pregnancy Outcomes and Its Interaction with Maternal Age in Chinese Urban Women.

J Diabetes Res 2021 18;2021:5516937. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 10034, China.

Background: The prevalence of gestational diabetes mellitus (GDM) has been dramatically increasing worldwide. The aims of this study were to examine associations of GDM with pregnancy outcomes in Chinese urban women and to evaluate the interaction between GDM and other major risk factors for the risk of adverse pregnancy outcomes.

Methods: A retrospective analysis included 8844 women who delivered live singletons at ≥28 weeks of gestation between June 2012 and March 2013 among Chinese urban women. Structured questionnaires were used to collect information on demographic characteristics, lifestyle behavior, medical history, and pregnancy outcomes. The diagnosis of GDM was made between 24 and 28 gestational weeks according to the International Association of Diabetes and Pregnancy Study Groups criteria. Logistic regression models were used to assess the association of GDM with pregnancy outcomes and to examine the interaction between GDM and other major risk factors including maternal age, prepregnancy body mass index, and gestational weight gain for the risk of pregnancy outcomes.

Results: 13.9% of women were diagnosed with GDM. We found that GDM was associated with higher risk of cesarean delivery (odds ratio (OR) = 1.69, 95% CI (confidence interval): 1.48-1.92), preterm birth (OR = 1.32, 95% CI: 1.07-1.64), macrosomia (OR = 1.69, 95% CI: 1.34-2.13), and large for gestational age (LGA, OR = 1.43, 95% CI: 1.18-1.73) after adjustment for potential confounders. We also observed the interaction between GDM and maternal age for the risk of cesarean delivery ( for interaction = 0.025), and the OR of GDM for cesarean delivery was 1.71 (95% CI: 1.49-1.97) among women aged less than 35 years.

Conclusions: GDM was associated with an increased risk of cesarean delivery, preterm birth, macrosomia, and LGA in Chinese urban women, and there was an interaction between GDM and maternal age for the risk of cesarean delivery.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2021/5516937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154302PMC
December 2021

Mid-Infrared Luminescence of the High Stability Perovskite CsPbErBr-ZrF-BaF-LaF-AlF-NaF Fluoride Glass.

ACS Appl Mater Interfaces 2021 Jun 9;13(25):30008-30019. Epub 2021 Jun 9.

School of Materials Science and Engineering, Institute of Material Physics, Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, and Tianjin Key Laboratory for Photoelectric Materials and Devices, and National Demonstration Center for Experimental Function Materials Education, Tianjin University of Technology, Tianjin 300384, China.

Perovskites have been studied because of their adjustable wavelength range, high color purity, and wide color gamut. However, they still face some problems such as poor stability and insufficient infrared luminescence. The perovskite glass can improve the stability and luminescence properties of the perovskite. In this paper, a highly stable CsPbErBr-ZBLAN fluoride glass with mid-infrared and visible light emission was prepared. The ZBLAN fluoride glass has good inertness, which can improve the stability of the CsPbErBr perovskite. The CsPbErBr-ZBLAN fluoride glass can prevent the perovskite from being destroyed by water, oxygen, and laser. The Er replaces Pb to bond with Br to become the luminescent center of the CsPbErBr-ZBLAN perovskite glass, which extends the luminescence to the mid-infrared region. In addition, its luminescent intensity is significantly higher than those of the ZBLAN-Er glass and CsPbErBr perovskite. After irradiation with a 365 nm UV lamp for 13 h, the luminescence intensity of the CsPbErBr-ZBLAN perovskite glass decreases only by 10%. The EDS spectrum shows that the elements of the CsPbErBr perovskite are uniformly distributed in the glass matrix. The X-ray diffraction spectrum shows that the sample has both the CsPbErBr perovskite phase and the glass phase. This indicates that CsPbErBr is well crystallized in the ZBLAN glass matrix. The three parameters calculated by the Judd-Ofelt theory show that the CsPbErBr perovskite can increase the covalency and asymmetry around the rare earth ion Er. The transmission electron microscope can clearly see the morphological structure of the CsPbErBr perovskite in the ZBLAN glass matrix. The infrared Fourier transform spectroscopy shows that the sample has lower phonon energy. This proves that the sample has good infrared luminescence characteristics. Finally, the visible and infrared light sources were prepared. Under the irradiation of the 365 nm ultraviolet lamp and 980 nm laser, the perovskite glass produces green light and infrared emission.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.1c04865DOI Listing
June 2021

Triboelectric Rotary Motion Sensor for Industrial-Grade Speed and Angle Monitoring.

Sensors (Basel) 2021 Mar 2;21(5). Epub 2021 Mar 2.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Mechanical motion sensing and monitoring is an important component in the field of industrial automation. Rotary motion is one of the most basic forms of mechanical motion, so it is of great significance for the development of the entire industry to realize rotary motion state monitoring. In this paper, a triboelectric rotary motion sensor (TRMS) with variable amplitude differential hybrid electrodes is proposed, and an integrated monitoring system (IMS) is designed to realize real-time monitoring of industrial-grade rotary motion state. First, the operating principle and monitoring characteristics are studied. The experiment results indicate that the TRMS can achieve rotation speed measurement in the range of 10-1000 rpm with good linearity, and the error rate of rotation speed is less than 0.8%. Besides, the TRMS has an angle monitoring range of 360° and its resolution is 1.5° in bidirectional rotation. Finally, the applications of the designed TRMS and IMS prove the feasibility of self-powered rotary motion monitoring. This work further promotes the development of triboelectric sensors (TESs) in industrial application.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s21051713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958622PMC
March 2021

Learning to Match Anchors for Visual Object Detection.

IEEE Trans Pattern Anal Mach Intell 2021 Jan 12;PP. Epub 2021 Jan 12.

Modern CNN-based object detectors assign anchors for ground-truth objects under the restriction of object-anchor Intersection-over-Union (IoU). In this study, we propose a learning-to-match (LTM) method to break IoU restriction, allowing objects to match anchors in a flexible manner. LTM updates hand-crafted anchor assignment to "free" anchor matching by formulating detector training in the Maximum Likelihood Estimation (MLE) framework. During the training phrase, LTM is implemented by converting the detection likelihood to anchor matching loss functions which are plug-and-play. Minimizing the matching loss functions drives learning and selecting features which best explain a class of objects with respect to both classification and localization. LTM is extended from anchor-based detectors to anchor-free detectors, validating the general applicability of learnable object-feature matching mechism for visual object detection. Experiments on MS COCO dataset demonstrate that LTM detectors consistently outperform counterpart detectors with significant margins. The last but not the least, LTM require negligible computational cost in both training and inference phrases as it does not involve any additional architecture or parameter. Code has been made publicly available.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TPAMI.2021.3050494DOI Listing
January 2021

Screening study of blood-supplementing active components in water decoction of processed with yellow rice wine based on response surface methodology.

Pharm Biol 2020 Dec;58(1):1167-1176

College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, P. R. China.

Context: (Oliv.) Diels (Apiaceae) (syn. Maxim var. Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect.

Objective: To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions.

Materials And Methods: Ferulic acid and crude polysaccharide were used in optimizing the preparation technology for WASD through response surface methodology. The independent variables were liquid-solid ratio, soaking time, and extraction time. Eighty Kunming mice were randomly divided into normal control, model, and six intervention groups ( = 10). The intervention groups were given different WASD fractions by gavage (5 or 10 g/kg). The model intervention groups received acetylphenyl hydrazine (subcutaneous injection) and cyclophosphamide (intraperitoneal injection). Duration of study, 9 days. The components of blood-supplementing fractions were analyzed.

Results: The optimum extraction parameters were liquid-solid ratio, 7.69:1 mL/g; soaking time, 119.78 min; and extraction time, 143.35 min. The optimal OD value was 0.8437. RBC, WBC, and Hb in the water fraction (5, 10 g/kg) and -butanol fraction (10 g/kg) intervention groups increased significantly compared with the model group ( < 0.05). Polysaccharide and caffeic acid contents of water fraction were 252.565 and 0.346 μg/mg, respectively; ferulic acid was not detected. Caffeic acid and ferulic acid contents of -butanol fraction were 1.187 and 0.806 μg/mg, respectively, polysaccharide was not detected.

Conclusions: The optimum preparation technology of WASD was obtained, and the water, -butanol fractions were blood-supplementing fractions. This study provides a theoretical foundation for further application of WAS in the pharmaceutical industry.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/13880209.2020.1844760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877401PMC
December 2020

Tracking the Insider Attacker: A Blockchain Traceability System for Insider Threats.

Sensors (Basel) 2020 Sep 16;20(18). Epub 2020 Sep 16.

Institute for Cyber Security, School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China.

The insider threats have always been one of the most severe challenges to cybersecurity. It can lead to the destruction of the organisation's internal network system and information leakage, which seriously threaten the confidentiality, integrity and availability of data. To make matters worse, since the attacker has authorized access to the internal network, they can launch the attack from the inside and erase their attack trace, which makes it challenging to track and forensics. A blockchain traceability system for insider threats is proposed in this paper to mitigate the issue. First, this paper constructs an insider threat model of the internal network from a different perspective: insider attack forensics and prevent insider attacker from escaping. Then, we analyze why it is difficult to track attackers and obtain evidence when an insider threat has occurred. After that, the blockchain traceability system is designed in terms of data structure, transaction structure, block structure, consensus algorithm, data storage algorithm, and query algorithm, while using differential privacy to protect user privacy. We deployed this blockchain traceability system and conducted experiments, and the results show that it can achieve the goal of mitigating insider threats.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s20185297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570583PMC
September 2020

Artificial intelligence-assisted cytology for detection of cervical intraepithelial neoplasia or invasive cancer: A multicenter, clinical-based, observational study.

Gynecol Oncol 2020 10 16;159(1):171-178. Epub 2020 Aug 16.

National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:

Objective: Artificial intelligence (AI) could automatedly detect abnormalities in digital cytological images, however, the effect in cervical cancer screening is inconclusive. We aim to evaluate the performance of AI-assisted cytology for the detection of histologically cervical intraepithelial lesions (CIN) or cancer.

Methods: We trained a supervised deep learning algorithm based on 188,542 digital cytological images. Between Mar 13, 2017, and Oct 20, 2018, 2145 referral women from organized screening were enrolled in a multicenter, clinical-based, observational study. Cervical specimen was sampled to generate two liquid-based slides: one random slide was allocated to AI-assisted reading, and the other to manual reading conducted by skilled cytologists from senior hospital and cytology doctors from primary hospitals. HPV testing and colposcopy-directed biopsy was performed, and histological result was regarded as reference. We calculated the relative sensitivity and relative specificity of AI-assisted reading compared to manual reading for CIN2+. This trial was registered, number ChiCTR2000034131.

Results: In the referral population, AI-assisted reading detected 92.6% of CIN 2 and 96.1% of CIN 3+, significantly higher than or similar to manual reading. AI-assisted reading had equivalent sensitivity (relative sensitivity 1.01, 95%CI, 0.97-1.05) and higher specificity (relative specificity 1.26, 1.20-1.32) compared to skilled cytologists; whereas higher sensitivity (1.12, 1.05-1.20) and specificity (1.36, 1.25-1.48) compared to cytology doctors. In HPV-positive women, AI-assisted reading improved specificity for CIN1 or less at no expense of reduction of sensitivity compared to manual reading.

Conclusions: AI-assisted cytology may contribute to the primary cytology screening or triage. Further studies are needed in general population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2020.07.099DOI Listing
October 2020

Physiological and proteomics responses of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry ( L.) leaves to NaCl and NaHCO stress.

Plant Signal Behav 2020 10 30;15(10):1798108. Epub 2020 Jul 30.

Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, Northeast Forestry University, Harbin, Heilongjiang, China.

In order to find out the response mechanism of nitrogen assimilation and glutamine/glutamine family of amino acids metabolism in mulberry ( L.) leaves under NaCl and NaHCO stress, and to reveal its role in salt alkali adaptation. The effects of the nitrogen metabolism of mulberry leaves were studied under 100 mmol L NaCl and NaHCO stress.The results showed that the activity of NR and the content of TN and SP did not change significantly, the expression of NiR, Fd-NiR, gene and theactivity of NiR increased significantly under NaCl stress, but nitrogen assimilation was inhibited under NaHCO stress. NaCl stress had no significant effect on the expression and activity of GS and GOGAT in mulberry leaves. Under NaHCO stress, the expression of Fd-GOGAT, Fd-GOGAT2, gene, and the activity of GS and GOGAT were significantly decreased. NaCl stress can promote the accumulation of Pro, Put and Spd in mulberry leaves. The accumulation of Pro under NaHCO stress is greater than that under NaCl stress. NaCl stress also induced the up-regulation of GAD, GAD1 and gene expression, so promoting the synthesis of GABA may be an adaptive mechanism for mulberry to cope with NaCl stress, but the expression of GAD did not change significantly and gene expression lower than CK under NaHCO stress. Although both NaCl and NaHCO stress could promote the synthesis of GSH by up-regulation of GCLM expression, GSH under NaHCO stress was significantly higher than that under NaCl stress, the content of HO was still significantly higher than that of NaCl stress, that means GSH may not play a key role in alleviating the oxidative damage in mulberry leaves caused by salt and alkali.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/15592324.2020.1798108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550533PMC
October 2020

OpCode-Level Function Call Graph Based Android Malware Classification Using Deep Learning.

Sensors (Basel) 2020 Jun 29;20(13). Epub 2020 Jun 29.

School of Computer Science and Engineering, Institute for Cyber Security, University of Electronic Science and Technology of China (UESTC), Chengdu 611731, China.

Due to the openness of an Android system, many Internet of Things (IoT) devices are running the Android system and Android devices have become a common control terminal for IoT devices because of various sensors on them. With the popularity of IoT devices, malware on Android-based IoT devices is also increasing. People's lives and privacy security are threatened. To reduce such threat, many researchers have proposed new methods to detect Android malware. Currently, most malware detection products on the market are based on malware signatures, which have a fast detection speed and normally a low false alarm rate for known malware families. However, they cannot detect unknown malware and are easily evaded by malware that is confused or packaged. Many new solutions use syntactic features and machine learning techniques to classify Android malware. It has been known that analysis of the Function Call Graph (FCG) can capture behavioral features of malware well. This paper presents a new approach to classifying Android malware based on deep learning and OpCode-level FCG. The FCG is obtained through static analysis of Operation Code (OpCode), and the deep learning model we used is the Long Short-Term Memory (LSTM). We conducted experiments on a dataset with 1796 Android malware samples classified into two categories (obtained from Virusshare and AndroZoo) and 1000 benign Android apps. Our experimental results showed that our proposed approach with an accuracy of 97 % outperforms the state-of-the-art methods such as those proposed by Nikola et al. and Hou et al. (IJCAI-18) with the accuracy of 97 % and 91 % , respectively. The time consumption of our proposed approach is less than the other two methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s20133645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374318PMC
June 2020

The improved photoresponse properties of self-powered NiO/ZnO heterojunction arrays UV photodetectors with designed tunable Fermi level of ZnO.

J Colloid Interface Sci 2020 Oct 26;577:279-289. Epub 2020 May 26.

School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education and Tianjin Key Laboratory for Photoelectric Materials and Devices, Tianjin University of Technology, Tianjin 300384, China. Electronic address:

Self-powered ultraviolet (UV) photodetectors (PDs) based on ZnO heterojunctions have attracted more attention due to the simple preparation and excellent photoresponse performance without any power supply. The self-powered UV PDs based on NiO nanoflakes/ZnO nanorod arrays (NRs) heterojunctions were fabricated by a low-cost, simple chemical bath deposition (CBD) method. The crystal quality, optical and electronic properties of ZnO NRs is modified by Al ions additions in the precursor solution. The heterojunction devices with ZnO NRs grown in 0.5% Al ions additions precursor solution exhibit a narrow UV spectral selectivity, high photoresponsivity R (85.12 mA/W) and detectivity D* (1.74 × 10 cm·Hz/W) and a fast response speed (~2 ms) under 378 nm UV light for low intensity irradiance (0.2 mW/cm) at zero bias. The large built-in electric field of the NiO/ZnO heterojunction with the increased Fermi level of ZnO NRs provide a strong driving force to separate and transfer the photo-generated carriers, decrease the recombination of the carriers and then improve the photoresponse performance of heterojunction devices without external bias.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2020.05.077DOI Listing
October 2020

Epitaxial growth of highly stable perovskite CsPbBr/nZnS/Al core/multi-shell quantum dots with aluminium self-passivation.

Nanotechnology 2020 Sep 1;31(37):375703. Epub 2020 Jun 1.

School of Materials Science and Engineering, Institute of Material Physics, Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, and Tianjin Key Laboratory for Photoelectric Materials and Devices, and National Demonstration Center for Experimental Function Materials Education, Tianjin University of Technology, Tianjin 300384, People's Republic of China.

As a new type of colloidal nanocrystals, perovskite quantum dots (QDs) have received widespread attention. Water and oxygen in the air can affect the luminous efficiency of quantum dots, which can degrade the surface of QDs and affect their luminescence efficiency. Herein we discuss the synthesis of high-quality QDs using an uncomplicated coating method by which an ultrathin epitaxial Al self-passivation layer bearing homogeneous ligands can be coated on the QDs. The core/shell perovskite QDs maintain high luminescence efficiency and photostability. The CsPbBr/2ZnS/Al QDs were only attenuated by 10% after 14 h of exposure to LED light. The temperature-dependent photoluminescence properties of the all-inorganic perovskite QDs, such as the PL intensity, emission peak position, and the full width at half maximum (FWHM), were investigated. The results indicated that the activation energy of QDs increases with the increase of the number of ZnS shell layers, its stability increases significantly. The introduction of Al does not change the luminescence mechanism of QDs. Finally, we have made flexible light-emitting device with CsPbBr/2ZnS/Al QDs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab9868DOI Listing
September 2020

Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.

J Ethnopharmacol 2020 Sep 14;259:112872. Epub 2020 May 14.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China. Electronic address:

Ethnopharmacological Relevance: Huang-lian-Jie-du decoction (HLJDD) is a traditional Chinese medicine prescription for clearing away heat, purging fire and detoxifying, which can be used to treat sepsis, stroke, Alzheimer's disease and gastrointestinal diseases. Our previous studies have shown that HLJDD can effectively alleviate acute ulcerative colitis (UC) in mice, and its n-butanol fraction (HLJDD-NBA) is the effective fraction. The aim of this study is to further investigate the mechanism of HLJDD and HLJDD-NBA in relieving UC in mice from a holistic perspective.

Methods: The acute UC model of BABL/c mice was induced by 3.5% (w/v) dextran sodium sulfate drinking water. At the same time of modeling, HLJDD and HLJDD-NBA were given orally for treatment respectively. During the experiment, the clinical symptoms of mice were recorded and the physiological and biochemical indexes of mice were detected after the experiment. In addition, the plasma metabolites of mice in each group were detected and analyzed by ultra-high performance liquid chromatography quadrupole time of flight mass spectrometry and multivariate statistical analysis method. Then, the potential target metabolic pathway of drug intervention was screened through the enrichment analysis of differential metabolites. Finally, we use molecular simulation docking technology to further explore the molecular regulatory mechanism of HLJDD and HLJDD-NBA on potential target metabolic pathways.

Results: HLJDD and HLJDD-NBA intervention can significantly reduce the disease activity index of UC mice, inhibit colon length shortening and pathological damage, and relieve the abnormal changes of physiological and biochemical parameters of UC mice. Moreover, HLJDD and HLJDD-NBA can significantly inhibit the metabolic dysfunction of UC mice by reversing the abnormal changes of 24 metabolites in UC mice, and the arachidonic acid metabolic pathway and glycerophospholipid metabolic pathway are the target metabolic pathways regulated by them. Further literature review and molecular simulation docking analysis showed that HLJDD and HLJDD-NBA may inhibit the disorder of arachidonic acid metabolism pathway and glycerophospholipid metabolism pathway by inhibiting COX-2 protein expression and PLA2, 5-LOX activity.

Conclusions: Our experiments revealed that HLJDD and HLJDD-NBA can alleviate UC of mice by regulating arachidonic acid metabolism and glycerophospholipid metabolism, which points out the direction for further research and development of HLJDD as a new anti-ulcer drug.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2020.112872DOI Listing
September 2020

Novel Self-Powered Photodetector with Binary Photoswitching Based on SnS/TiO Heterojunctions.

ACS Appl Mater Interfaces 2020 May 6;12(20):23145-23154. Epub 2020 May 6.

School of Materials Science and Engineering, Institute of Material Physics, Key Laboratory of Display Materials and Photoelectric Devices, Ministry of Education, and Tianjin Key Laboratory for Photoelectric Materials and Devices, Tianjin University of Technology, Tianjin 300384, China.

Binary photoresponse characteristics can help realize optical signal processing and logic operations. UV photodetectors (PDs) with SnS nanoflakes and TiO nanorod arrays (NRs) show a novel binary photoswitching behavior (change in current from positive to negative) by manipulating the light wavelength without an external power source, utilizing the interfacial recombination of the photogenerated carriers in the type-I SnS/TiO heterojunctions. The enhanced responsivity (), detectivity (), and fast photoresponse time for self-powered SnS/TiOPDs can be achieved by adjusting the phase ratio of SnS and SnS nanoflakes. The binary photoswitching in the self-powered UV PDs can be applied in the encrypted optical signal processing and imaging in some special conditions without external bias.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c05247DOI Listing
May 2020

Synergic effect of and von Willebrand factor in pathogenesis of deep vein thrombosis.

Vascular 2020 Jun 6;28(3):309-313. Epub 2020 Jan 6.

Department of Vascular Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, China.

Objectives: In cardiovascular disease, deep vein thrombosis is one of the vital symptoms causing pulmonary thromboembolism. However, the pathogenesis of deep vein thrombosis is still not clear. One of the critical factors leading to deep vein thrombosis is the platelet aggregation that is mediated by a set of key genes including platelet membrane protein coded by .

Methods: Deep vein thrombosis model was established according to the previous protocol, and venous blood and thrombi were collected for further analysis.

Results: The dynamic changes of and coagulation factor, von Willebrand factor, were observed in deep vein thrombosis models. Meanwhile, critical proteins participating in adhesion and binding of platelets such as epithelial membrane protein 2 (EMP2), vascular cell adhesion protein 1 (VCAM1), immunoreceptor tyrosine-based activation motif 1 (ITAM1), integrin subunit alpha M (ITGAM), or fibronectin were also differentially expressed in deep vein thrombosis models.

Conclusions: Application of heparin could reverse these dynamic changes in deep vein thrombosis models. Thus, we explained the potential synergic role of and von Willebrand factor in regulating the occurrence of deep vein thrombosis and provide therapeutic target against cardiovascular disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/1708538119896446DOI Listing
June 2020

Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function.

Front Pharmacol 2019 21;10:1354. Epub 2019 Nov 21.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Evidence shows that intestinal inflammation, oxidative stress, and injury of mucosal barrier are closely related to the pathogenesis of ulcerative colitis (UC). Huang-lian-Jie-du Decoction (HLJDD) is a well-known prescription of traditional Chinese medicine with anti-inflammatory and antioxidative activities, which may be used to treat UC. However, its therapeutic effect and mechanism are still unclear. In this study, the UC model of BABL/c mice were established by DSS [3.5% (w/v)], and HLJDD was given orally for treatment at the same time. During the experiment, the clinical symptoms of mice were scored by disease activity index (DAI). Besides, the effects of HLJDD on immune function, oxidative stress, colon NF-κB and Nrf2 signaling pathway, and intestinal mucosal barrier function in UC mice were also investigated. The results showed that HLJDD could alleviate body weight loss and DAI score of UC mice, inhibit colonic shortening and relieve colonic pathological damage, and reduce plasma and colon MPO levels. In addition, HLJDD treatment significantly up-regulated plasma IL-10, down-regulated TNF-α and IL-1β levels, and inhibited the expression of NF-κB p65, p-IκKα/β, and p-IκBα proteins in the colon. Moreover, NO and MDA levels in colon tissues were significantly reduced after HLJDD treatment, while GSH, SOD levels and Nrf2, Keap1 protein expression levels were remarkably elevated. Additionally, HLJDD also protected intestinal mucosa by increasing the secretion of mucin and the expression of ZO-1 and occludin in colonic mucosa. These results indicate that HLJDD could effectively alleviate DSS-induced mice UC by suppressing NF-κB signaling pathway, activating Nrf2 signaling pathway, and enhancing intestinal barrier function.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.01354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900672PMC
November 2019

Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice.

Biomed Pharmacother 2020 Jan 22;121:109638. Epub 2019 Nov 22.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China. Electronic address:

Huang-lian-Jie-du Decoction (HLJDD) is a classical prescription for clearing away heat and detoxification. In order to screen the effective fraction of HLJDD in the treatment of ulcerative colitis (UC) in mice and explore its effects on intestinal flora in UC mice, we prepared different polar fractions of HLJDD by system solvent extraction method. Subsequently, the contents of 13 active compounds in different polar fractions of HLJDD were determined by HPLC. Further, the UC model induced by dextran sodium sulfate was used to evaluate the therapeutic effects of different polar fractions of HLJDD. Finally, cecal contents were used for sequencing and analysis of bacterial 16S rRNA genes. The results showed that the yield of HLJDD-n-butanol (HLJDD-NBA) fraction was the highest, and the content or proportion of 13 active compounds in HLJDD-NBA fraction were the most similar to HLJDD. In addition, in vivo pharmacodynamic experiments showed that HLJDD-NBA intervention not only significantly alleviated the clinical symptoms of UC mice and ameliorated the pathological damage of colon tissue, but also showed significant anti-inflammatory and antioxidative effects (p < 0.05), which were comparable to HLJDD (p > 0.05). Moreover, both HLDD and HLJDD-NBA treatments can restore the intestinal flora homeostasis of UC mice by inhibiting the growth of intestinal pathogens and preventing the decrease of beneficial bacteria. Meanwhile, they can also significantly correct the dysfunction of intestinal flora in UC mice. In conclusion, we proved that HLJDD-NBA fraction is an effective fraction of HLJDD in treating UC in mice, and it can maintain the intestinal flora homeostasis of UC mice, which increases our understanding of the mechanism of HLJDD in treating UC and lays a foundation for the development of new anti-ulcer drugs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.109638DOI Listing
January 2020

Association of β-fibrinogen polymorphisms and venous thromboembolism risk: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Nov;98(48):e18204

Department of Vascular Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu Province, China.

Background: Venous thromboembolism (VTE) is a multifactorial disease in which genetic and acquired risk factors may contribute to disease pathogenesis. Several studies have demonstrated that β-fibrinogen (FGB) polymorphisms are associated with the risk of VTE. However, the results of these studies were not totally consistent. In this paper, we performed a meta-analysis to further investigate the relationship between FGB polymorphisms and susceptibility to VTE.

Methods: To identify studies pertinent to the focused question, the following databases were systematically searched: PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, and Wanfang Data. The strength of correlations was evaluated by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity, type of disorders, and source of control were also performed.

Results: Overall, A total of 18 relevant case-control studies met the inclusion criteria and were incorporated in this meta-analysis, involving 3033 VTE cases and 4547 healthy controls. FGB -455G>A polymorphism and -148C>T polymorphism were not significantly associated with susceptibility to VTE in overall populations. However, results of stratified analysis demonstrated that among Caucasian population, the -455G>A mutation was negatively associated with the risk of VTE under all genetic comparison models (A:G OR = 0.80 95% CI = 0.70-0.91; GA + AA:GG OR = 0.80 95% CI = 0.68-0.93; GA:GG OR = 0.84 95% CI = 0.71-0.98; AA:GG + GA OR = 0.61 95% CI = 0.43-0.87; AA:GG OR = 0.57 95% CI = 0.40-0.82), which indicates FGB -455G>A polymorphism may be a protective factor for VTE. There was no correlation between -148C>T polymorphism and susceptibility to VTE in all subgroup analyses.

Conclusion: FGB -455G>A polymorphism was associated with a decreased risk of VTE among the Caucasian population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890318PMC
November 2019

A facile method to fabricate a porous Si/C composite with excellent cycling stability for use as the anode in a lithium ion battery.

Chem Commun (Camb) 2019 Nov 24;55(89):13438-13441. Epub 2019 Oct 24.

Mathematic Information College, Shaoxing University, Shaoxing, 312000, China.

Porous Si/C has been fabricated by dehydrating Si/sucrose mixed powder with concentrated HSO. The obtained Si/C presents excellent cycling stability with a capacity retention of 85.6% in the 920th cycle at 100 mA g, compared with only 13.2% for pure Si in the 100th cycle.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc06661fDOI Listing
November 2019

[Relationship between prenatal negative life events and pregnancy outcomes].

Wei Sheng Yan Jiu 2019 Sep;48(5):774-779

Department of Gynecology and Obstetrics, Peking University First Hospital, Beijing 100034, China.

Objective: To assess the prevalence of prenatal negative life events, and explore the effect of prenatal negative life events on pregnancy outcomes.

Methods: A total of 9137 postpartum women( average age: 28. 76±6. 53 years) who delivered live neonates with gestational age ≥28 weeks between April, 2012 to March, 2013 in 15 hospitals in Beijing, Guangdong, Hunan, Hubei, Sichuan and Shaanxi provinces were enrolled. Self-made questionnaire was used to collect general information, occurrence of negative life events during pregnancy, complications during pregnancy and pregnancy outcomes. Logistic regression models were used to analyze the effect of prenatal negative life events on adverse pregnancy outcomes and influencing factors of adverse pregnancy outcomes.

Results: In total of 1395 women( 15. 3%) had experienced prenatal negative life events, and 5439 women( 59. 5%) had adverse pregnancy outcomes. After adjusting for covariates, women who experienced prenatal negative life events had an increased risk of preterm birth( OR = 1. 257, 95% CI 1. 051-1. 504), and delivering low birth weight infants( OR = 1. 316, 95% CI 1. 055-1. 643). Multivariate Logistic regression models showed that prenatal negative life events( OR = 1. 201, 95% CI1. 056-1. 365), pregnancy-induced hypertension( OR = 2. 278, 95% CI 1. 867-2. 781), pre-pregnancy overweight or obese( OR = 1. 299, 95% CI 1. 140-1. 480) and delivery age above 35 years old( OR = 1. 197, 95% CI 1. 014-1. 413) were risk factors for adverse pregnancy outcomes; and primiparity( OR = 0. 808, 95% CI 0. 715-0. 913) were protective factors for adverse pregnancy outcomes. Among different types of negative life events, women with family disharmony had increased risk of adverse pregnancy outcomes than those without family disharmony after adjusting for covariates( OR = 1. 259, 95% CI1. 076-1. 473).

Conclusion: In this study, prenatal negative life events were prevalent, and prenatal negative life events may increase the risk of pregnancy outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2019
-->