Publications by authors named "Xiaoping Wang"

733 Publications

Role of diet in osteoporosis incidence: Umbrella review of meta-analyses of prospective observational studies.

Crit Rev Food Sci Nutr 2021 Oct 13:1-10. Epub 2021 Oct 13.

School of Physical Education and Sports Training, Shanghai University of Sport, Shanghai Municipality, P.R. China.

An umbrella review and meta-analysis were conducted to summarize evidence for the association between dietary factors and the incidence of osteoporosis in adults. Only systematic reviews or meta-analyses were eligible for this study. Two researchers independently performed reading, data extraction, and quality evaluation of the included literature. The outcomes included in this study were all associated with osteoporosis, including osteoporotic fractures and low bone density. A total of 54 studies were included in this study, with 83 adjusted hazard ratios on diet, dairy group (n = 13), alcohol (n = 2), tea (n = 6), coffee (n = 3), micronutrient (n = 31), dietary pattern (n = 21), and foods (n = 7) regarding the incidence of osteoporosis. Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) quality assessment method was used in this study. The high, medium, low and very low quality studies accounted for 27.7, 41, 21.7 and 9.6% of this study, respectively. Based on the included literature studies in this umbrella review, it was found that dietary factors have a relevant impact on the incidences of human osteoporosis, appropriate consumption of dairy products, vegetables, fruits, and micronutrients, as well as reduced intake of alcohol and coffee, can reduce the risk of osteoporosis.
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http://dx.doi.org/10.1080/10408398.2021.1989374DOI Listing
October 2021

Role of diet in osteoporosis incidence: Umbrella review of meta-analyses of prospective observational studies.

Crit Rev Food Sci Nutr 2021 Oct 13:1-10. Epub 2021 Oct 13.

School of Physical Education and Sports Training, Shanghai University of Sport, Shanghai Municipality, P.R. China.

An umbrella review and meta-analysis were conducted to summarize evidence for the association between dietary factors and the incidence of osteoporosis in adults. Only systematic reviews or meta-analyses were eligible for this study. Two researchers independently performed reading, data extraction, and quality evaluation of the included literature. The outcomes included in this study were all associated with osteoporosis, including osteoporotic fractures and low bone density. A total of 54 studies were included in this study, with 83 adjusted hazard ratios on diet, dairy group (n = 13), alcohol (n = 2), tea (n = 6), coffee (n = 3), micronutrient (n = 31), dietary pattern (n = 21), and foods (n = 7) regarding the incidence of osteoporosis. Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) quality assessment method was used in this study. The high, medium, low and very low quality studies accounted for 27.7, 41, 21.7 and 9.6% of this study, respectively. Based on the included literature studies in this umbrella review, it was found that dietary factors have a relevant impact on the incidences of human osteoporosis, appropriate consumption of dairy products, vegetables, fruits, and micronutrients, as well as reduced intake of alcohol and coffee, can reduce the risk of osteoporosis.
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http://dx.doi.org/10.1080/10408398.2021.1989374DOI Listing
October 2021

Transcriptome and structure analysis in root of under NaCl treatment.

PeerJ 2021 22;9:e12133. Epub 2021 Sep 22.

State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of State Forestry and Grassland Administration on Tropical Forestry, Research Institute of Tropical Forestry, Chinese Academy of Forestry, Guangzhou, China.

Background: High soil salinity seriously affects plant growth and development. Excessive salt ions mainly cause damage by inducing osmotic stress, ion toxicity, and oxidation stress. is a highly salt-tolerant plant, commonly grown as wind belts in coastal areas with sandy soils. However, little is known about its physiology and the molecular mechanism of its response to salt stress.

Results: Eight-week-old seedlings grown from rooted cuttings were exposed to salt stress for varying durations (0, 1, 6, 24, and 168 h under 200 mM NaCl) and their ion contents, cellular structure, and transcriptomes were analyzed. Potassium concentration decreased slowly between 1 h and 24 h after initiation of salt treatment, while the content of potassium was significantly lower after 168 h of salt treatment. Root epidermal cells were shed and a more compact layer of cells formed as the treatment duration increased. Salt stress led to deformation of cells and damage to mitochondria in the epidermis and endodermis, whereas stele cells suffered less damage. Transcriptome analysis identified 10,378 differentially expressed genes (DEGs), with more genes showing differential expression after 24 h and 168 h of exposure than after shorter durations of exposure to salinity. Signal transduction and ion transport genes such as and were enriched among DEGs in the early stages (1 h or 6 h) of salt stress, while expression of genes involved in programmed cell death was significantly upregulated at 168 h, corresponding to changes in ion contents and cell structure of roots. Oxidative stress and detoxification genes were also expressed differentially and were enriched among DEGs at different stages.

Conclusions: These results not only elucidate the mechanism and the molecular pathway governing salt tolerance, but also serve as a basis for identifying gene function related to salt stress in .
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http://dx.doi.org/10.7717/peerj.12133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464194PMC
September 2021

Biomimetic Recognition of Quinones in Water by an Endo-Functionalized Cavity with Anthracene Sidewalls.

Angew Chem Int Ed Engl 2021 Sep 26. Epub 2021 Sep 26.

Southern University of Science and Technology, Department of Chemistry, Xueyuan Blvd 1088, Nanshan District, 518055, Shenzhen, CHINA.

Selective molecular recognition in water is the foundation of numerous biological functions. In contrast, this remains a challenge for synthetic hosts. Recently, several biomimetic hosts brought hope by shielding hydrogen bonding in a hydrophobic cavity. However, general guidelines for the design and synthesis of such biomimetic hosts are still urgently needed. Herein, we propose the concept of endo -functionalized cavity and the strategy of "simultaneous construction" to address this issue. The concept and the strategy were demonstrated in the construction of a biomimetic host for selectively recognizing quinones in water. The host was synthesized by joining two pieces of bent anthracene dimer through amide bond formation, affording a deep hydrophobic cavity and inward-directing hydrogen bonding sites simultaneously. The host can selectively recognize quinones over their close analogues in water, and its association affinity to p -benzoquinone is the highest among all the known hosts and is even comparable to that of the bioreceptor. The binding with anthraquinone reaches nanomolar affinity. Shielded hydrogen bonding, C-H···π, and charge transfer interactions, and the hydrophobic effect were revealed to be responsible for the high binding affinity and selectivity. The concept and the synthetic strategy demonstrated here may be used as one of general guidelines for biomimetic molecular recognition in water.
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http://dx.doi.org/10.1002/anie.202112267DOI Listing
September 2021

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder.

Neural Plast 2021 8;2021:3741104. Epub 2021 Sep 8.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.

Background: Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear.

Methods: A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier.

Results: Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%.

Conclusion: Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.
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http://dx.doi.org/10.1155/2021/3741104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8443365PMC
September 2021

Microplastics in a Remote Lake Basin of the Tibetan Plateau: Impacts of Atmospheric Transport and Glacial Melting.

Environ Sci Technol 2021 10 15;55(19):12951-12960. Epub 2021 Sep 15.

Key Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100101, China.

Plastic pollution is fast becoming one of the most pressing global issues that we currently face. Remote areas, such as the polar regions and the Tibetan Plateau, are now also exposed to microplastic contamination. However, with the impact of global warming, the transport of microplastics within the glacier-lake basins in such regions remains unclear. In this work, the Nam Co Basin in the Tibetan Plateau was selected to study the characteristics of microplastics in the rain fallout, lake water, glacial runoff, and non-glacial runoff. Fiber and films were the most common microplastic morphologies in all water samples; a higher proportion (37%) of light-weighing polypropylene and small-size (50-300 μm, ∼30%) microplastics were found in the glacial runoff. Air mass trajectory analysis showed that microplastics could be transported through the atmosphere over a distance of up to 800 km. For microplastic loading in lakes, the atmospheric fallout was estimated to be 3.3 tons during the monsoon season, whereas the contributions of glacial runoff (∼41 kg) and non-glacial runoff (∼522 kg) were relatively low. For the microplastic loading in glaciers, the atmospheric deposition was ∼500 kg/yr, and the output caused by glacial melting only accounted 8% of the total atmospheric input. All these results suggested that the dominant pathway through which microplastics enter remote mountainous lake basins is atmospheric deposition, and once deposited on glaciers, microplastics will be stored for a long time. This work provides quantitative evidence elucidating the fate of microplastics in alpine lake environments.
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http://dx.doi.org/10.1021/acs.est.1c03227DOI Listing
October 2021

Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders.

Brain Imaging Behav 2021 Sep 4. Epub 2021 Sep 4.

Department of Psychiatry, the Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, 410011, Hunan, China.

Young males are often associated with more violence, leading to some serious negative consequences. However, the physiology and the neuroimaging patterns underlying juvenile violence remain unclear. Of the limited knowledge on juvenile violence, the default mode network has been known to be associated with its pathophysiology. This study aimed to investigate functional connectivity alterations of the default mode network in male juvenile violent offenders. 31 juvenile violent offenders in a high-security facility, who were convicted of aggressive behaviors by court, and 28 normal controls from a middle school were recruited as participants. They underwent a resting-state functional magnetic resonance imaging scan. And independent component analysis approaches were used to analyze their data. Compared to the normal controls, the juvenile violent offenders showed a different default mode network pattern, with the functional connectivity increased in the posterior cingulate, and decreased in the right middle temporal, left angular, right precuneus and right middle frontal cortex. Our findings revealed that the male juvenile violent offenders were associated with abnormal default mode network functional connectivity, which might be a neuroimaging basis for their tendency to violence.
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http://dx.doi.org/10.1007/s11682-021-00535-3DOI Listing
September 2021

Perfluoroalkyl substances in precipitation from the Tibetan Plateau during monsoon season: Concentrations, source regions and mass fluxes.

Chemosphere 2021 Nov 4;282:131105. Epub 2021 Jun 4.

Key Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing, 100101, China; South-East Tibetan Plateau Station for Integrated Observation and Research of Alpine Environment, Chinese Academy of Sciences, Nyingchi 860119, China.

Atmospheric wet deposition is an important process for the occurrence of perfluoroalkyl substances (PFASs) in polar/remote mountain regions; however, there are limited data on PFASs in precipitation from the Tibetan Plateau (TP). Precipitation (rain from May to October 2017) was therefore collected across the TP to investigate the concentrations, composition profiles, sources, and fluxes of perfluoroalkyl acids (PFAAs). The average ∑PFAA concentrations ranged from 212.3 pg L to 547.7 pg L, and perfluoroalkyl carboxylic acids (PFCAs) accounted for 87% of the measured PFAAs (mean value). Significant positive associations (p < 0.05) were found for most PFCAs in the southeast TP, indicating that they may come from similar sources. The monthly PFAA deposition flux ranged from 12.6 to 68.9 ng m month, decreasing from east to west. As climate of the eastern TP is controlled mainly by the Indian monsoon, indicating that the Indian monsoon plays an important role in delivering PFAAs to the TP. PCA (principal component analysis) combined with back-trajectory analysis was used to estimate the atmospheric transport pathways, and the PSCF (potential source contribution function) model was applied to define the potential source regions of individual PFAAs. The results suggested that northeast India, Bangladesh, and southern Nepal are the potential sources of C4-C7 PFCAs; C8-C10 PFCAs are more influenced by emissions from southern Nepal and Bhutan; while the source regions of long-chain PFCAs (C11-C12) can be attributed to northern India and Pakistan. Specifically, PFOS (perfluorooctane sulfonic acid) has a local contribution from the central TP.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131105DOI Listing
November 2021

The Impact of Host Genotype, Intestinal Sites and Probiotics Supplementation on the Gut Microbiota Composition and Diversity in Sheep.

Biology (Basel) 2021 Aug 12;10(8). Epub 2021 Aug 12.

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

Three sampling strategies with a 16s rRNA high-throughput sequencing and gene expression assay (by RT-PCR) were designed, to better understand the host and probiotics effect on gut microbiota in sheep. Sampling: (1) colon contents and back-fat tissues from small-tailed Han sheep (SHS), big-tailed Hulun Buir sheep (BHBS), and short-tailed Steppe sheep (SHBS) ( = 12, 14, 12); (2) jejunum, cecum and colon contents, and feces from Tan sheep (TS, = 6); (3) feces from TS at 4 time points (nonfeeding, 30 and 60 feeding days, and stop feeding 30 days) with probiotics supplementation ( = 7). The results indicated SHS had the highest abundance, the thinnest back-fat, and the lowest expression of , , , , and . Some bacteria orders and families could be potential biomarkers for sheep breeds with a distinct distribution of bacterial abundance, implying the host genotype is predominant in shaping unique microbiota under a shared environment. The microbiota diversity and populations significantly changed after 60 days of feeding but restored to its initial state, with mostly colonies, after 30 days ceased. The microbiota composition was greatly different between the small and large intestines, but somewhat different between the large intestine and feces; feces may be reliable for studying large intestinal microbiota in ruminants.
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http://dx.doi.org/10.3390/biology10080769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389637PMC
August 2021

Identification of three metallothioneins in the black soldier fly and their functions in Cd accumulation and detoxification.

Environ Pollut 2021 Oct 23;286:117146. Epub 2021 Apr 23.

Hubei International Scientific and Technological Cooperation Base of Waste Conversion By Insects, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:

The black soldier fly (BSF) Hermetia illucens has a strong tolerance to cadmium stress. This helps to use BSF in entomoremediation of heavy metal pollution. Rich metallothionein (MT) proteins were thought to be important for some insects to endure the toxicity of heavy metal. We identified and characterized three MTs genes in BSF (BSFMTs), including BSFMT1, BSFMT2A, and BSFMT2B. Molecular modeling was used to predict metal binding sites. Phylogenetic analysis was used to identify gene families. Overexpression of the recombinant black soldier fly metallothioneins was found to confer Cd tolerance in Escherichia coli. Finally, functions of BSFMTs in BSF were explored through RNA interference (RNAi). RNAi results of BSFMT2B showed that the larval fresh weight decreased significantly, and the larvae mortality increased significantly. This study suggests that BSFMTs have important properties in Cd detoxification and tolerance in BSF. Further characterization analyses of physiological function about metallothioneins are necessary in BSF and other insects.
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http://dx.doi.org/10.1016/j.envpol.2021.117146DOI Listing
October 2021

Genetic diversity and epidemiology of human rhinovirus among children with severe acute respiratory tract infection in Guangzhou, China.

Virol J 2021 08 23;18(1):174. Epub 2021 Aug 23.

The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.

Background: Human rhinovirus (HRV) is one of the major viruses of acute respiratory tract disease among infants and young children. This work aimed to understand the epidemiological and phylogenetic features of HRV in Guangzhou, China. In addition, the clinical characteristics of hospitalized children infected with different subtype of HRV was investigated.

Methods: Hospitalized children aged < 14 years old with acute respiratory tract infections were enrolled from August 2018 to December 2019. HRV was screened for by a real-time reverse-transcription PCR targeting the viral 5'UTR.

Results: HRV was detected in 6.41% of the 655 specimens. HRV infection was frequently observed in children under 2 years old (57.13%). HRV-A and HRV-C were detected in 18 (45%) and 22 (55%) specimens. All 40 HRV strains detected were classified into 29 genotypes. The molecular evolutionary rate of HRV-C was estimated to be 3.34 × 10 substitutions/site/year and was faster than HRV-A (7.79 × 10 substitutions/site/year). Children who experienced rhinorrhoea were more common in the HRV-C infection patients than HRV-A. The viral load was higher in HRV-C detection group than HRV-A detection group (p = 0.0148). The median peak symptom score was higher in patients with HRV-C infection as compared to HRV-A (p = 0.0543), even though the difference did not significance.

Conclusion: This study revealed the molecular epidemiological characteristics of HRV in patients with respiratory infections in southern China. Children infected with HRV-C caused more severe disease characteristics than HRV-A, which might be connected with higher viral load in patients infected with HRV-C. These findings will provide valuable information for the pathogenic mechanism and treatment of HRV infection.
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http://dx.doi.org/10.1186/s12985-021-01645-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382100PMC
August 2021

Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking.

Evid Based Complement Alternat Med 2021 11;2021:4280482. Epub 2021 Aug 11.

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.

The Guanxin Suhe pill (GSP), a traditional Chinese medicine, has been widely used to treat angina pectoris (AP) in Chinese clinical practice. However, research on the bioactive ingredients and underlying mechanisms of GSP in AP remains scarce. In this study, a system pharmacology approach integrating gastrointestinal absorption (GA) evaluation, drug-likeness (DL) evaluation, target exploration, protein-protein-interaction analysis, Gene Ontology (GO) enrichment analysis, network construction, and molecular docking was adopted to explore its potential mechanisms. A total of 481 ingredients from five herbs were collected, and 242 were qualified based on GA and DL evaluation. Target exploration identified 107 shared targets between GSP and AP. Protein-protein interaction identified VEGFA (vascular endothelial growth factor A), TNF (tumor necrosis factor), CCL2 (C-C motif chemokine ligand 2), FN1 (fibronectin 1), MMP9 (matrix metallopeptidase 9), PTGS2 (prostaglandin-endoperoxide synthase 2), IL10 (interleukin 10), CXCL8 (C-X-C motif chemokine ligand 8), IL6 (interleukin 6), and INS (insulin) as hub targets for GSP, which were involved in the inflammatory process, ECM proteolysis, glucose metabolism, and lipid metabolism. GO enrichment identified top pathways in the biological processes, molecular functions, and cell components, explaining GSP's potential AP treatment mechanism. Positive regulation of the nitric oxide biosynthetic process and the response to hypoxia ranked highest of the biological processes; core targets that GSP can regulate in these two pathways were PTGS2 and NOS2, respectively. Molecular docking verified the interactions between the core genes in the pathway and the active ingredients. The study lays a foundation for further experimental research and clinical application.
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http://dx.doi.org/10.1155/2021/4280482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373492PMC
August 2021

Indirect comparison of TIMI, HEART and GRACE for predicting major cardiovascular events in patients admitted to the emergency department with acute chest pain: a systematic review and meta-analysis.

BMJ Open 2021 08 18;11(8):e048356. Epub 2021 Aug 18.

Department of Emergency, Fujian Provincial Hospital, Fuzhou, Fujian, China

Background: The study aimed to compare the predictive values of the thrombolysis in myocardial infarction (TIMI); History, Electrocardiography, Age, Risk factors and Troponin (HEART) and Global Registry in Acute Coronary Events (GRACE) scoring systems for major adverse cardiovascular events (MACEs) in acute chest pain (ACP) patients admitted to the emergency department (ED).

Methods: We systematically searched PubMed, Embase and the Cochrane Library from their inception to June 2020; we compared the following parameters: sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), diagnostic OR (DOR) and area under the receiver operating characteristic curves (AUC).

Results: The pooled sensitivity and specificity for TIMI, HEART and GRACE were 0.95 and 0.36, 0.96 and 0.50, and 0.78 and 0.56, respectively. The pooled PLR and NLR for TIMI, HEART and GRACE were 1.49 and 0.13, 1.94 and 0.08, and 1.77 and 0.40, respectively. The pooled DOR for TIMI, HEART and GRACE was 9.18, 17.92 and 4.00, respectively. The AUC for TIMI, HEART and GRACE was 0.80, 0.80 and 0.70, respectively. Finally, the results of indirect comparison suggested the superiority of values of TIMI and HEART to those of GRACE for predicting MACEs, while there were no significant differences between TIMI and HEART for predicting MACEs.

Conclusions: TIMI and HEART were superior to GRACE for predicting MACE risk in ACP patients admitted to the ED.
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http://dx.doi.org/10.1136/bmjopen-2020-048356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375746PMC
August 2021

-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity.

Circ Res 2021 Oct 13;129(8):e166-e182. Epub 2021 Aug 13.

Biochemistry and Molecular Biology (Y.W., X. Lu, Q.Q., P.Z., X.M., X. Lin, X.X.), Mayo Clinic, Rochester, MN.

[Figure: see text].
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http://dx.doi.org/10.1161/CIRCRESAHA.121.319104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484060PMC
October 2021

Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.

EC Psychol Psychiatr 2021 28;10(7):11-23. Epub 2021 Jun 28.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.

Objective: The aim of this study was to examine if cholinergic receptor nicotinic beta 3 subunit () was a common genetic basis for both nicotine dependence and schizophrenia.

Methods: Two promoter single nucleotide polymorphisms (SNPs) were genotyped in 773 patients with schizophrenia and 302 healthy volunteers. Associations between smoking, schizophrenia, smoking+schizophrenia and were analyzed. The mRNA expression of in human brains was examined, and the expression correlations between and dopaminergic and GABAergic receptor genes were evaluated.

Results: The association between and smoking was significant in the total sample, less significant in the smoking with schizophrenia, and suggestive in the smoking without schizophrenia. had significant mRNA expression that was correlated with dopaminergic or GABAergic receptor expression in human brains. The two SNPs had significant cis-acting regulatory effects on mRNA expression.

Conclusions: Risk for smoking behavior was associated with . mRNA is abundant in human brain and could play important role in the pathogenesis of smoking behavior.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341072PMC
June 2021

Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.

EC Psychol Psychiatr 2021 28;10(7):11-23. Epub 2021 Jun 28.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.

Objective: The aim of this study was to examine if cholinergic receptor nicotinic beta 3 subunit () was a common genetic basis for both nicotine dependence and schizophrenia.

Methods: Two promoter single nucleotide polymorphisms (SNPs) were genotyped in 773 patients with schizophrenia and 302 healthy volunteers. Associations between smoking, schizophrenia, smoking+schizophrenia and were analyzed. The mRNA expression of in human brains was examined, and the expression correlations between and dopaminergic and GABAergic receptor genes were evaluated.

Results: The association between and smoking was significant in the total sample, less significant in the smoking with schizophrenia, and suggestive in the smoking without schizophrenia. had significant mRNA expression that was correlated with dopaminergic or GABAergic receptor expression in human brains. The two SNPs had significant cis-acting regulatory effects on mRNA expression.

Conclusions: Risk for smoking behavior was associated with . mRNA is abundant in human brain and could play important role in the pathogenesis of smoking behavior.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341072PMC
June 2021

Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway.

Ann Transl Med 2021 May;9(9):803

Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University/Jinan Maternity and Child Care Hospital Affiliated, Jinan, China.

Background: Integrin β6 (ITGB6), a key submonomer of integrin αvβ6, plays an important role in epithelial-to-mesenchymal transition (EMT), wound healing, epithelial-derived tumor growth, fibrosis, and epithelial repair. However, the role of ITGB6 in cervical carcinoma (CC) remains elusive.

Methods: The expression levels of ITGB6 in CC tissues and cell lines were determined using quantitative real-time polymerase chain reaction (qRT-PCR). The cell viability, proliferation, apoptosis, migration, and invasion were evaluated by Cell Counting Kit-8 (CCK-8), colony-forming, flow cytometry, and Transwell assay, respectively. The expression of related proteins, including EMT markers and the Janus kinase/signal transducer and activator of transcription (JAK/STAT3) signaling markers, were detected using western blotting.

Results: The ITGB6 expression in CC tissues and cells (C-33A, Hela, SiHa, and Caski) was remarkably higher than that in paracarcinoma tissues and ECT1/E6E7 cells. The data from The Cancer Genome Atlas (TCGA) data set suggested that patients with CC with high ITGB6 expression showed poorer overall survival (OS). Compared with the empty transfection group (si-NC), si-ITGB6 restrained the proliferation, migration, and invasion of SiHa and Hela cells, while promoting cell apoptosis. si-ITGB6 suppression decreased the expression of Snail, vimentin, and N-cadherin, while increasing E-cadherin expression. Further research showed that si-ITGB6 reduced p-JAK1/JAK1, p-JAK2/JAK2, and p-STAT3/STAT3 expression in the JAK/STAT3 signaling pathway. Interestingly, proliferation, migration, invasion, and the expressions of the molecular markers of the JAK/STAT3 signaling pathway and EMT pathway induced by ITGB6 were altered by RO8191 (JAK/STAT3 pathway activator). Furthermore, the protein expression levels of Snail, vimentin, N-cadherin, p-STAT3/STAT3, p-JAK1/JAK1, and p-JAK2/JAK2 in tumor tissues were higher than those in adjacent normal tissue, while the expression level of E-cadherin was downregulated in tumor tissues.

Conclusions: Silencing of ITGB6 restrains cell proliferation, migration and invasion, and promotes apoptosis in CC by inhibiting JAK/STAT signaling pathways. Thus, ITGB6 may perhaps be a new and useful candidate target for treating CC.
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http://dx.doi.org/10.21037/atm-21-1669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246156PMC
May 2021

Memristive Circuit Design of Brain-Like Emotional Learning and Generation.

IEEE Trans Cybern 2021 Jul 14;PP. Epub 2021 Jul 14.

In this work, a bionic memristive circuit with the functions of emotional learning and generation is proposed, which can perform brain-like emotional learning and generation based on various types of input information. The proposed circuit is designed based on the brain emotional learning theory in the limbic system, which mainly includes three layers of design: 1) the bottom layer is the design of the basic unit modules, such as neuron and synapse; 2) the middle layer is the design of the functional modules related to emotional learning in the limbic system, such as the amygdala, thalamus, and so on; and 3) the top layer is the design of the overall circuit, which is used to realize the function of the emotional generation. A 2-D emotional space composed of valence and arousal signals is adopted. According to the above bottom-up circuit design method, the valence and arousal signals can be generated, respectively, by designing corresponding emotional learning circuits, so as to form continuous emotions. The volatile and nonvolatile memristors are mainly used to mimic the functions of the neuron and synapse at the bottom layer of the circuit to achieve the core emotional learning function of the middle layer, thereby constructing a brain-like information processing architecture to realize the function of the emotional generation in the top layer. The simulation results in PSPICE show that the proposed circuit can learn and generate emotions like humans. If the proposed circuit is applied to a humanoid robot platform through further research, the robot may have the ability of personalized emotional interaction with humans, so that it can be effectively used in emotional companionship and other aspects.
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http://dx.doi.org/10.1109/TCYB.2021.3090811DOI Listing
July 2021

Identification of the JNK-Active Triple-Negative Breast Cancer Cluster Associated with an Immunosuppressive Tumor Microenvironment.

J Natl Cancer Inst 2021 Jul 12. Epub 2021 Jul 12.

Section of Translational Breast Cancer Research, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Background: Although an immunosuppressive tumor microenvironment (TME) is key for tumor progression, the molecular characteristics associated with the immunosuppressive TME remain unknown in triple-negative breast cancer (TNBC). Our previous functional proteomic study of TNBC tumors identified that C-JUN N-terminal kinase (JNK) pathway-related molecules were enriched in a cluster associated with the inflammatory pathway. However, the role of the JNK pathway in the TNBC TME is still unclear.

Methods: Transcriptomic analysis was conducted using The Cancer Genome Atlas (TCGA) datasets. The effect of JNK-IN-8, a covalent pan-JNK inhibitor, on TNBC tumor growth, lung metastasis, and the TME was measured in TNBC syngeneic mouse models (n = 13 per group). Tumor (n = 43) or serum (n = 46) samples from TNBC patients were analyzed using multiplex immunohistochemistry or Luminex assay. All statistical tests were 2-sided.

Results: CIBERSORT analysis revealed that TNBC patients with high pJNK level (n = 47) had more regulatory T cell (Treg) infiltration than those with low pJNK level (n = 47) (P = .02). Inhibition of JNK signaling statistically significantly reduced tumor growth (P < .001) and tumor-infiltrating Tregs (P = .02) while increasing the infiltration of CD8+ T cells in TNBC mouse models through the reduction of C-C motif ligand 2 (CCL2). Tumor-associated macrophages (TAMs) were the predominant cells secreting CCL2, and inhibition of JNK signaling reduced CCL2 secretion of human primary macrophages. Moreover, in patients with TNBC (n = 43), those with high levels of CCL2+ TAMs had more Treg and less CD8+ T cell infiltration (P = .04), and serum CCL2 level was associated with poor overall survival (hazard ratio = 2.65, 95% confidence interval = 1.29 to 5.44; P = .008) in TNBC patients (n = 46).

Conclusions: The JNK/C-JUN/CCL2 axis contributes to TNBC aggressiveness via forming an immunosuppressive TME and can offer novel therapeutic strategies for TNBC.
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http://dx.doi.org/10.1093/jnci/djab128DOI Listing
July 2021

Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression.

Breast Cancer Res Treat 2021 Sep 9;189(2):333-345. Epub 2021 Jul 9.

Section of Translational Breast Cancer Research, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks targeted therapies. Patients with TNBC have a very poor prognosis because the disease often metastasizes. New treatment approaches addressing drivers of metastasis and tumor growth are crucial to improving patient outcomes. Developing targeted gene therapy is thus a high priority for TNBC patients. PEA15 (phosphoprotein enriched in astrocytes, 15 kDa) is known to bind to ERK, preventing ERK from being translocated to the nucleus and hence blocking its activity. The biological function of PEA15 is tightly regulated by its phosphorylation at Ser104 and Ser116. However, the function and impact of phosphorylation status of PEA15 in the regulation of TNBC metastasis and in epithelial-to-mesenchymal transition (EMT) are not well understood.

Methods: We established stable cell lines overexpressing nonphosphorylatable (PEA15-AA) and phospho-mimetic (PEA15-DD) mutants. To dissect specific cellular mechanisms regulated by PEA15 phosphorylation status, we performed RT-PCR immune and metastasis arrays. In vivo mouse models were used to determine the effects of PEA15 phosphorylation on tumor growth and metastasis.

Results: We found that the nonphosphorylatable mutant PEA15-AA prevented formation of mammospheres and expression of EMT markers in vitro and decreased tumor growth and lung metastasis in in vivo experiments when compared to control, PEA15-WT and phosphomimetic PEA15-DD. However, phosphomimetic mutant PEA15-DD promoted migration, mesenchymal marker expression, tumorigenesis, and lung metastasis in the mouse model. PEA15-AA-mediated inhibition of breast cancer cell migratory capacity and tumorigenesis was the partial result of decreased expression of interleukin-8 (IL-8). Further, we identified that expression of IL-8 was possibly mediated through one of the ERK downstream molecules, Ets-1.

Conclusions: Our results show that PEA15 phosphorylation status serves as an important regulator for PEA15's dual role as an oncogene or tumor suppressor and support the potential of PEA15-AA as a therapeutic strategy for treatment of TNBC.
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http://dx.doi.org/10.1007/s10549-021-06316-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357760PMC
September 2021

Simplifying the Measurement of College Students' Career Planning: the Development of Career Student Planning Scale during the COVID-19 Pandemic.

Exp Results 2021 18;2:e4. Epub 2021 Jan 18.

School of Social & Behavioral Sciences, University of Arkansas at Monticello, 562 University Drive, Monticello, Arkansas 71656, USA.

We created a new, 8-item scale called "Career Student Planning Scale (CSPS)" for a valid and reliable measure regarding college students' career planning during a traumatic event, such as a pandemic. CSPS is conceptually similar to the career decision-making difficulty questionnaire (CDDQ) and the career decision self-efficacy (CDSE) scale. CSPS leans towards questions about college students' perceptions about career planning, rather than intuitions about career decision-making; it also inquires about how participants conceptualize about their career plans to be correct, rather than the more extreme idea about how their intuitions are correct: we developed this scale to capture the latter construct. We included the coronavirus anxiety scale (CAS), CDDQ, the general procrastination scale (GPS), and the CDSE short form (CDSE-SF) as covariates to ensure that CSPS has distinct effects on their career paths. Our findings indicate the CSPS has acceptable psychometric properties and demonstrates a valuable input to those measures.
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http://dx.doi.org/10.1017/exp.2020.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847742PMC
January 2021

Disrupted Asymmetry of Inter- and Intra-Hemispheric Functional Connectivity at Rest in Medication-Free Obsessive-Compulsive Disorder.

Front Neurosci 2021 9;15:634557. Epub 2021 Jun 9.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.

Disrupted functional asymmetry of cerebral hemispheres may be altered in patients with obsessive-compulsive disorder (OCD). However, little is known about whether anomalous brain asymmetries originate from inter- and/or intra-hemispheric functional connectivity (FC) at rest in OCD. In this study, resting-state functional magnetic resonance imaging was applied to 40 medication-free patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs). Data were analyzed using the parameter of asymmetry (PAS) and support vector machine methods. Patients with OCD showed significantly increased PAS in the left posterior cingulate cortex, left precentral gyrus/postcentral gyrus, and right inferior occipital gyrus and decreased PAS in the left dorsolateral prefrontal cortex (DLPFC), bilateral middle cingulate cortex (MCC), left inferior parietal lobule, and left cerebellum Crus I. A negative correlation was found between decreased PAS in the left DLPFC and Yale-Brown Obsessive-compulsive Scale compulsive behavior scores in the patients. Furthermore, decreased PAS in the bilateral MCC could be used to distinguish OCD from HCs with a sensitivity of 87.50%, an accuracy of 88.46%, and a specificity of 89.47%. These results highlighted the contribution of disrupted asymmetry of intra-hemispheric FC within and outside the cortico-striato-thalamocortical circuits at rest in the pathophysiology of OCD, and reduced intra-hemispheric FC in the bilateral MCC may serve as a potential biomarker to classify individuals with OCD from HCs.
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http://dx.doi.org/10.3389/fnins.2021.634557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220135PMC
June 2021

A Novel Identified Long Non-coding RNA, lncRNA MEF2C-AS1, Inhibits Cervical Cancer via Regulation of miR-592/RSPO1.

Front Mol Biosci 2021 8;8:687113. Epub 2021 Jun 8.

Department of Gynaecology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University/ Jinan Maternity and Child Care Hospital, Jinan, China.

Our purpose was to investigate the effect of lncRNA MEF2C antisense RNA 1 (MEF2C-AS1) on cervical cancer and further explore its underlying molecular mechanisms. The proliferation, migration and invasion of CC cells were determined by counting Kit-8 (CCK-8), colony formation assay, and transwell assays, respectively. qRT-PCR and western blot were conducted to quantitatively detect the expression of lncRNA MEF2C-AS1, miR-592 and R-spondin1 (RSPO1). Kaplan-Meier survival curve from the Cancer Genome Atlas (TCGA) database and the Gene Expression Profiling Interactive Analysis (GEPIA) website was used to describe the overall survival. Bioinformatics analysis was performed to search the downstream target of lncRNA MEF2C-AS1 and miR-592. Luciferase reporter assay was conducted to detect the interaction between lncRNA MEF2C-AS1 and miR-592 or miR-592 and RSPO1. The data from GEPIA website showed that lncRNA MEF2C-AS1 expression was down-regulated in CC tissues and also associated with survival rate of CC patients. Moreover, the results of qRT-PCR also showed lncRNA MEF2C-AS1 was lowly expressed in CC cells. Subsequently, we confirmed that overexpression of lncRNA MEF2C-AS1 inhibited the proliferation, migration and invasion of CC cells. Further research illustrated that lncRNA MEF2C-AS1 was the target of miR-592, and RSPO1 was the downstream target gene of miR-592. Importantly, functional research findings indicated that lncRNA MEF2C-AS1 inhibited CC via suppressing miR-592 by targeting RSPO1. In our study, we demonstrated the functional role of the lncRNA MEF2C-AS1-miR-592-RSPO1 axis in the progression of CC, which provides a latent target for CC treatment.
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http://dx.doi.org/10.3389/fmolb.2021.687113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217607PMC
June 2021

Aggregation-induced phosphorescence sensitization in two heptanuclear and decanuclear gold-silver sandwich clusters.

Chem Sci 2020 Oct 30;12(2):702-708. Epub 2020 Oct 30.

College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China

The strategy of aggregation-induced emission enhancement (AIEE) has been proven to be efficient in wide areas and has recently been adopted in the field of metal nanoclusters. However, the relationship between atomically precise clusters and AIEE is still unclear. Herein, we have successfully obtained two few-atom heterometallic gold-silver hepta-/decanuclear clusters, denoted and , and determined their structures by X-ray diffraction and mass spectrometry. The nature of the Au⋯Ag interactions thereof is demonstrated through energy decomposition analysis to be far-beyond typical closed-shell metal-metal interaction dominated by dispersion interaction. Furthermore, a positive correlation has been established between the particle size of the nanoaggregates and the photoluminescence quantum yield for , manifesting AIEE control upon varying the stoichiometric ratio of Au : Ag in atomically-precise clusters.
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http://dx.doi.org/10.1039/d0sc05095dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179010PMC
October 2020

Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder.

Neural Plast 2021 1;2021:9966378. Epub 2021 Jun 1.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.

Background: Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD.

Methods: The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Forty medication-free patients and 38 gender-, education-, and age-matched healthy controls (HCs) were recruited for resting-state functional magnetic resonance imaging. Seed-based functional connectivity (FC) was used to analyze the data. LIBSVM (library for support vector machines) was designed to identify whether altered FC could be applied to differentiate OCD.

Results: Patients with OCD showed remarkably decreased FC values between the left NAc and the bilateral orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and between the right NAc and the left OFC at rest in the reward circuit. Moreover, decreased left NAc-bilateral MPFC connectivity can be deemed as a potential biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a specificity of 76.32%.

Conclusion: The current results emphasize the importance of the reward circuit in the pathogenesis of OCD.
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http://dx.doi.org/10.1155/2021/9966378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187042PMC
June 2021

Anhydride-linked β-cyclodextrin-bonded silica stationary phases with enhanced chiral separation ability in liquid chromatography.

J Chromatogr A 2021 Aug 9;1651:462338. Epub 2021 Jun 9.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; College of Chemistry, Zhengzhou University, Zhengzhou 450001, China; School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, China. Electronic address:

β-Cyclodextrin can be functionalized by derivation of reactive hydroxyl on the ring due to its special chiral environment and structural characteristics, which can be used to identify or separate a variety of chiral substance. In this manuscript, a series of excellent chiral stationary phases for high-performance liquid chromatography were developed for enantioseparation by using anhydride modified β-cyclodextrin bearing chiral (R/S)-α-phenethylamine or (S)-(+)-2-amino-1-propanol. They were characterized by elemental analysis, Fourier transform infrared spectra (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and BET. These chiral stationary phases presented good resolution and repeatability, about 17 kinds of enantiomers were effectively separated. And most of enantiomers were separated better than those reported in the literature in the same both normal and reversed phase modes. The RSD values of R for repeatability and column-to-column were below 0.44% and 2.83%, respectively. All results revealed that these new CSPs show great prospect for chiral separation in actual applications.
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http://dx.doi.org/10.1016/j.chroma.2021.462338DOI Listing
August 2021

Ultrasonography-guided radiofrequency ablation combined with lauromacrogol sclerotherapy for mixed thyroid nodules.

Am J Transl Res 2021 15;13(5):5035-5042. Epub 2021 May 15.

Department of Ultrasound, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai City, China.

Objective: To evaluate the safety and effectiveness of ultrasonography-guided radiofrequency ablation combined with lauromacrogol foam sclerotherapy for the treatment of mixed thyroid nodules.

Methods: One hundred and nineteen patients with benign mixed thyroid nodules were included in this study. In all patients, radiofrequency ablation was performed on the solid components of nodules, and the cystic areas of nodules were treated with aspiration, irrigation with lauromacrogol injection and foam sclerotherapy. The nodule volume reduction ratio and thyroid-related laboratory tests were measured during operation and at 1, 3, 6, and 12 months after operation, and intraoperative and postoperative complications were recorded.

Results: A total of 136 mixed thyroid nodules from 119 patients all achieved complete ablation. At 1, 3, 6, and 12 months after treatment, the nodule volume decreased gradually while the volume reduction ratio increased gradually (P<0.05). The thyroid function of all patients returned to normal after operation, but 3 patients exhibited cyst recurrence. After the operation, no serious complications occurred.

Conclusion: Ultrasonography-guided radiofrequency ablation combined with lauromacrogol sclerotherapy is a safe and effective method for the treatment of mixed thyroid nodules with less surgical trauma and low incidence of complications.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205792PMC
May 2021

Low-temperature plasma radiofrequency ablation for the management of refractory cluster headache.

Wideochir Inne Tech Maloinwazyjne 2021 Jun 12;16(2):362-368. Epub 2020 Nov 12.

Pain Department, XuanWu Hospital, Capital Medical University, Beijing, China.

Introduction: Although the sphenopalatine ganglion (SPG) has been considered a site of therapeutic potential for cluster headache (CH), the optimal technique of SPG is still to be determined. Low-temperature plasma radiofrequency ablation (LTPRA) has been proposed as an alternative treatment for several neuropathic pain diseases.

Aim: To evaluate the effect of LTPRA of SPG in treating chronic and episodic CH.

Material And Methods: The patients with CH, who achieved temporary pain relief following SPG block, treated using LTPRA between January 2015 and October 2017 were reviewed. Seventy-six patients were included: 50 patients suffered from episodic CH and the remaining 26 patients from chronic CH. The primary outcomes were clinical improvement rate, defined as the percentage of partial and complete pain relief results at 1 day, 12 months, and 24 months of follow-up after the operation.

Results: Clinical improvement rates were 92.3%, 92.3% and 73.1% in chronic CH and 73.1%, 84% and 68% in episodic CH at each follow-up time point, respectively. 3 chronic CH patients and 7 episodic CH patients showed no pain relief after the operation. Drooping eyelids were found in 2 cases, one recovered at the 3-month follow-up but another one did not in the 24-month follow-up. No serious complications occurred intraoperatively or postoperatively.

Conclusions: LTPRA can be considered an effective and alternative surgical modality in treating patients with chronic and episodic CH, based on SPG block.
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http://dx.doi.org/10.5114/wiitm.2020.100739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193752PMC
June 2021

Correlation in thermal fluctuations induced by phase-locked hydrodynamic modes.

Phys Rev E 2021 May;103(5-1):053106

Department of Physics, HKUST, Clear Water Bay, Kowloon, Hong Kong, China.

Thermal fluctuations constitute a fundamental equilibrium phenomenon whose spatial and temporal correlations are governed by the relevant scales of molecular collisions. From the continuum point of view, thermal fluctuations in a fluid can be regarded as comprising a multitude of hydrodynamic modes (HMs) with random phases, each one having one degree of freedom. We show that in a two-dimensional fluid channel with the Navier slip boundary condition, in which the HMs are represented by periodic arrays of vortex and antivortex pairs, periodic modulation of the slip boundary condition can selectively suppress noncommensurate HMs while phase lock the remaining eigenmodes. As a result, thermal fluctuations would exhibit mesoscopic-scale spatial correlations, manifest as a spatially varying diffusion constant when evaluated from the fluctuation-dissipation theorem. Good agreement is shown with the molecular dynamics results. Such manifestation of equilibrium collective motion implies that instead of just being an alternative mathematical basis for expressing thermal fluctuations, in mesoscopic systems the HMs may be manipulated to have physical consequences very different from those expected in bulk fluid.
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http://dx.doi.org/10.1103/PhysRevE.103.053106DOI Listing
May 2021

Highly Effective Pd/MgO/γ-AlO Catalysts for CO Oxidative Coupling to Dimethyl Oxalate: The Effect of MgO Coating on γ-AlO.

ACS Appl Mater Interfaces 2021 Jun 9;13(24):28064-28071. Epub 2021 Jun 9.

Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

The support of MgO/γ-AlO was initially prepared by a multiple impregnation method and Pd was placed on the surface of the MgO/γ-AlO support via incipient wetness impregnation. Pd/MgO/γ-AlO (Pd/MAO) catalysts were systematically characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), CO-temperature-programmed desorption (TPD), transmission electron microscopy (TEM), CO-Fourier transform infrared (CO-FTIR), and X-ray photoelectron spectroscopy (XPS) and tested in the CO oxidative coupling to dimethyl oxalate (DMO) reaction. Compared to Pd/γ-AlO, the catalytic activities of the Pd/MAO catalysts improved significantly. The Pd/MAO catalyst with a 30% mass ratio of Mg to γ-AlO delivers 3 times higher STY of DMO than that of Pd/γ-AlO. It has been demonstrated that MgO covered γ-AlO layer-by-layer forming MAO supports, which can increase surface basicity and the interaction between Pd particles and the MAO supports. Moreover, the relationship between metal and support interaction and catalytic performance was discussed.
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http://dx.doi.org/10.1021/acsami.1c04051DOI Listing
June 2021
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